FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3215, 491 aa 1>>>pF1KE3215 491 - 491 aa - 491 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 15.5176+/-0.000512; mu= -26.8773+/- 0.032 mean_var=837.2885+/-177.334, 0's: 0 Z-trim(125.6): 95 B-trim: 937 in 1/59 Lambda= 0.044324 statistics sampled from 49657 (49820) to 49657 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.822), E-opt: 0.2 (0.584), width: 16 Scan time: 9.730 The best scores are: opt bits E(85289) NP_079090 (OMIM: 606872) E3 ubiquitin-protein liga ( 491) 3705 252.0 2.9e-66 NP_001271220 (OMIM: 606872) E3 ubiquitin-protein l ( 490) 3687 250.8 6.4e-66 XP_016868132 (OMIM: 606872) PREDICTED: E3 ubiquiti ( 531) 3667 249.6 1.6e-65 XP_016868133 (OMIM: 606872) PREDICTED: E3 ubiquiti ( 440) 3363 230.1 1e-59 XP_011514882 (OMIM: 606872) PREDICTED: E3 ubiquiti ( 370) 2848 197.0 7.5e-50 XP_016868134 (OMIM: 606872) PREDICTED: E3 ubiquiti ( 370) 2848 197.0 7.5e-50 >>NP_079090 (OMIM: 606872) E3 ubiquitin-protein ligase H (491 aa) initn: 3705 init1: 3705 opt: 3705 Z-score: 1310.7 bits: 252.0 E(85289): 2.9e-66 Smith-Waterman score: 3705; 100.0% identity (100.0% similar) in 491 aa overlap (1-491:1-491) 10 20 30 40 50 60 pF1KE3 MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQANKAKPAPRTQRTINRMPAKAPPGDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQANKAKPAPRTQRTINRMPAKAPPGDE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 EGFDYNEEERYDCKGGELFANQRRFPGHLFWDFQINILGEKDDTPVHFCDKCGLPIKIYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 EGFDYNEEERYDCKGGELFANQRRFPGHLFWDFQINILGEKDDTPVHFCDKCGLPIKIYG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 RMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCKRTYLSQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 RMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCKRTYLSQR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 DLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTEIPERFIMPPDKHHMSHIPPKQHIMM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 DLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTEIPERFIMPPDKHHMSHIPPKQHIMM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 PPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPRSVSQETFRISTRKHSNLITVPIQDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 PPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPRSVSQETFRISTRKHSNLITVPIQDD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 SNSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 SNSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 AAGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 AAGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 PHHYNPNSLPQFTEDQGTLSPPFTQPGGMSPGIWPAPRGPPPPPRLQGPPSQTPLPGPHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 PHHYNPNSLPQFTEDQGTLSPPFTQPGGMSPGIWPAPRGPPPPPRLQGPPSQTPLPGPHH 430 440 450 460 470 480 490 pF1KE3 PDQTRYRPYYQ ::::::::::: NP_079 PDQTRYRPYYQ 490 >>NP_001271220 (OMIM: 606872) E3 ubiquitin-protein ligas (490 aa) initn: 3315 init1: 3315 opt: 3687 Z-score: 1304.5 bits: 250.8 E(85289): 6.4e-66 Smith-Waterman score: 3687; 99.8% identity (99.8% similar) in 491 aa overlap (1-491:1-490) 10 20 30 40 50 60 pF1KE3 MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQANKAKPAPRTQRTINRMPAKAPPGDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQANKAKPAPRTQRTINRMPAKAPPGDE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 EGFDYNEEERYDCKGGELFANQRRFPGHLFWDFQINILGEKDDTPVHFCDKCGLPIKIYG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 -GFDYNEEERYDCKGGELFANQRRFPGHLFWDFQINILGEKDDTPVHFCDKCGLPIKIYG 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 RMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCKRTYLSQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCKRTYLSQR 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE3 DLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTEIPERFIMPPDKHHMSHIPPKQHIMM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTEIPERFIMPPDKHHMSHIPPKQHIMM 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE3 PPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPRSVSQETFRISTRKHSNLITVPIQDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPRSVSQETFRISTRKHSNLITVPIQDD 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE3 SNSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQ 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE3 AAGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPP 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE3 PHHYNPNSLPQFTEDQGTLSPPFTQPGGMSPGIWPAPRGPPPPPRLQGPPSQTPLPGPHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PHHYNPNSLPQFTEDQGTLSPPFTQPGGMSPGIWPAPRGPPPPPRLQGPPSQTPLPGPHH 420 430 440 450 460 470 490 pF1KE3 PDQTRYRPYYQ ::::::::::: NP_001 PDQTRYRPYYQ 480 490 >>XP_016868132 (OMIM: 606872) PREDICTED: E3 ubiquitin-pr (531 aa) initn: 3667 init1: 3667 opt: 3667 Z-score: 1297.1 bits: 249.6 E(85289): 1.6e-65 Smith-Waterman score: 3667; 100.0% identity (100.0% similar) in 486 aa overlap (6-491:46-531) 10 20 30 pF1KE3 MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQA :::::::::::::::::::::::::::::: XP_016 VWCGTYLLRAGNNRSYSGSAELRARTSGRYNELQGTNSSGSLGGLDVRRRIPIKLISKQA 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE3 NKAKPAPRTQRTINRMPAKAPPGDEEGFDYNEEERYDCKGGELFANQRRFPGHLFWDFQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NKAKPAPRTQRTINRMPAKAPPGDEEGFDYNEEERYDCKGGELFANQRRFPGHLFWDFQI 80 90 100 110 120 130 100 110 120 130 140 150 pF1KE3 NILGEKDDTPVHFCDKCGLPIKIYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NILGEKDDTPVHFCDKCGLPIKIYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRI 140 150 160 170 180 190 160 170 180 190 200 210 pF1KE3 EQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTE 200 210 220 230 240 250 220 230 240 250 260 270 pF1KE3 IPERFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IPERFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPR 260 270 280 290 300 310 280 290 300 310 320 330 pF1KE3 SVSQETFRISTRKHSNLITVPIQDDSNSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVSQETFRISTRKHSNLITVPIQDDSNSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIM 320 330 340 350 360 370 340 350 360 370 380 390 pF1KE3 PPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQM 380 390 400 410 420 430 400 410 420 430 440 450 pF1KE3 PPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLSPPFTQPGGMSPGIWP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLSPPFTQPGGMSPGIWP 440 450 460 470 480 490 460 470 480 490 pF1KE3 APRGPPPPPRLQGPPSQTPLPGPHHPDQTRYRPYYQ :::::::::::::::::::::::::::::::::::: XP_016 APRGPPPPPRLQGPPSQTPLPGPHHPDQTRYRPYYQ 500 510 520 530 >>XP_016868133 (OMIM: 606872) PREDICTED: E3 ubiquitin-pr (440 aa) initn: 3315 init1: 3315 opt: 3363 Z-score: 1193.1 bits: 230.1 E(85289): 1e-59 Smith-Waterman score: 3363; 99.8% identity (99.8% similar) in 441 aa overlap (51-491:1-440) 30 40 50 60 70 80 pF1KE3 DVRRRIPIKLISKQANKAKPAPRTQRTINRMPAKAPPGDEEGFDYNEEERYDCKGGELFA :::::::::: ::::::::::::::::::: XP_016 MPAKAPPGDE-GFDYNEEERYDCKGGELFA 10 20 90 100 110 120 130 140 pF1KE3 NQRRFPGHLFWDFQINILGEKDDTPVHFCDKCGLPIKIYGRMIPCKHVFCYDCAILHEKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NQRRFPGHLFWDFQINILGEKDDTPVHFCDKCGLPIKIYGRMIPCKHVFCYDCAILHEKK 30 40 50 60 70 80 150 160 170 180 190 200 pF1KE3 GDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRA 90 100 110 120 130 140 210 220 230 240 250 260 pF1KE3 SLENVHPPIAPPPTEIPERFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLENVHPPIAPPPTEIPERFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDI 150 160 170 180 190 200 270 280 290 300 310 320 pF1KE3 RAPPAELSMAPPPPRSVSQETFRISTRKHSNLITVPIQDDSNSGAREPPPPAPAPAHHHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RAPPAELSMAPPPPRSVSQETFRISTRKHSNLITVPIQDDSNSGAREPPPPAPAPAHHHP 210 220 230 240 250 260 330 340 350 360 370 380 pF1KE3 EYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSA 270 280 290 300 310 320 390 400 410 420 430 440 pF1KE3 PPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLS 330 340 350 360 370 380 450 460 470 480 490 pF1KE3 PPFTQPGGMSPGIWPAPRGPPPPPRLQGPPSQTPLPGPHHPDQTRYRPYYQ ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPFTQPGGMSPGIWPAPRGPPPPPRLQGPPSQTPLPGPHHPDQTRYRPYYQ 390 400 410 420 430 440 >>XP_011514882 (OMIM: 606872) PREDICTED: E3 ubiquitin-pr (370 aa) initn: 2848 init1: 2848 opt: 2848 Z-score: 1016.0 bits: 197.0 E(85289): 7.5e-50 Smith-Waterman score: 2848; 100.0% identity (100.0% similar) in 370 aa overlap (122-491:1-370) 100 110 120 130 140 150 pF1KE3 DFQINILGEKDDTPVHFCDKCGLPIKIYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDP :::::::::::::::::::::::::::::: XP_011 MIPCKHVFCYDCAILHEKKGDKMCPGCSDP 10 20 30 160 170 180 190 200 210 pF1KE3 VQRIEQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRASLENVHPPIAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VQRIEQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRASLENVHPPIAP 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE3 PPTEIPERFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPTEIPERFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAP 100 110 120 130 140 150 280 290 300 310 320 330 pF1KE3 PPPRSVSQETFRISTRKHSNLITVPIQDDSNSGAREPPPPAPAPAHHHPEYQGQPVVSHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPPRSVSQETFRISTRKHSNLITVPIQDDSNSGAREPPPPAPAPAHHHPEYQGQPVVSHP 160 170 180 190 200 210 340 350 360 370 380 390 pF1KE3 HHIMPPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HHIMPPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHI 220 230 240 250 260 270 400 410 420 430 440 450 pF1KE3 IAQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLSPPFTQPGGMSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IAQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLSPPFTQPGGMSP 280 290 300 310 320 330 460 470 480 490 pF1KE3 GIWPAPRGPPPPPRLQGPPSQTPLPGPHHPDQTRYRPYYQ :::::::::::::::::::::::::::::::::::::::: XP_011 GIWPAPRGPPPPPRLQGPPSQTPLPGPHHPDQTRYRPYYQ 340 350 360 370 >>XP_016868134 (OMIM: 606872) PREDICTED: E3 ubiquitin-pr (370 aa) initn: 2848 init1: 2848 opt: 2848 Z-score: 1016.0 bits: 197.0 E(85289): 7.5e-50 Smith-Waterman score: 2848; 100.0% identity (100.0% similar) in 370 aa overlap (122-491:1-370) 100 110 120 130 140 150 pF1KE3 DFQINILGEKDDTPVHFCDKCGLPIKIYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDP :::::::::::::::::::::::::::::: XP_016 MIPCKHVFCYDCAILHEKKGDKMCPGCSDP 10 20 30 160 170 180 190 200 210 pF1KE3 VQRIEQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRASLENVHPPIAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VQRIEQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRASLENVHPPIAP 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE3 PPTEIPERFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPTEIPERFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAP 100 110 120 130 140 150 280 290 300 310 320 330 pF1KE3 PPPRSVSQETFRISTRKHSNLITVPIQDDSNSGAREPPPPAPAPAHHHPEYQGQPVVSHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPPRSVSQETFRISTRKHSNLITVPIQDDSNSGAREPPPPAPAPAHHHPEYQGQPVVSHP 160 170 180 190 200 210 340 350 360 370 380 390 pF1KE3 HHIMPPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HHIMPPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHI 220 230 240 250 260 270 400 410 420 430 440 450 pF1KE3 IAQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLSPPFTQPGGMSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IAQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLSPPFTQPGGMSP 280 290 300 310 320 330 460 470 480 490 pF1KE3 GIWPAPRGPPPPPRLQGPPSQTPLPGPHHPDQTRYRPYYQ :::::::::::::::::::::::::::::::::::::::: XP_016 GIWPAPRGPPPPPRLQGPPSQTPLPGPHHPDQTRYRPYYQ 340 350 360 370 491 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 19:27:00 2016 done: Mon Nov 7 19:27:02 2016 Total Scan time: 9.730 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]