FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3154, 372 aa 1>>>pF1KE3154 372 - 372 aa - 372 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.7796+/-0.000657; mu= 11.5908+/- 0.040 mean_var=127.1062+/-25.449, 0's: 0 Z-trim(115.6): 42 B-trim: 0 in 0/51 Lambda= 0.113760 statistics sampled from 16104 (16146) to 16104 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.802), E-opt: 0.2 (0.496), width: 16 Scan time: 3.170 The best scores are: opt bits E(32554) CCDS42526.1 GDF1 gene_id:2657|Hs108|chr19 ( 372) 2604 437.8 7.3e-123 CCDS8581.1 GDF3 gene_id:9573|Hs108|chr12 ( 364) 524 96.4 4.1e-20 CCDS1701.1 GDF7 gene_id:151449|Hs108|chr2 ( 450) 408 77.5 2.6e-14 CCDS4503.1 BMP6 gene_id:654|Hs108|chr6 ( 513) 404 76.8 4.6e-14 CCDS13455.1 BMP7 gene_id:655|Hs108|chr20 ( 431) 402 76.5 5e-14 CCDS437.1 BMP8A gene_id:353500|Hs108|chr1 ( 402) 397 75.6 8.4e-14 CCDS444.1 BMP8B gene_id:656|Hs108|chr1 ( 402) 396 75.5 9.4e-14 CCDS4958.1 BMP5 gene_id:653|Hs108|chr6 ( 454) 396 75.5 1e-13 CCDS34926.1 GDF6 gene_id:392255|Hs108|chr8 ( 455) 385 73.7 3.6e-13 CCDS13254.1 GDF5 gene_id:8200|Hs108|chr20 ( 501) 375 72.1 1.2e-12 CCDS5464.1 INHBA gene_id:3624|Hs108|chr7 ( 426) 357 69.1 8.3e-12 CCDS13099.1 BMP2 gene_id:650|Hs108|chr20 ( 396) 352 68.2 1.4e-11 CCDS9715.1 BMP4 gene_id:652|Hs108|chr14 ( 408) 345 67.1 3.2e-11 CCDS8939.1 INHBE gene_id:83729|Hs108|chr12 ( 350) 342 66.5 3.9e-11 CCDS3588.1 BMP3 gene_id:651|Hs108|chr4 ( 472) 337 65.8 8.8e-11 >>CCDS42526.1 GDF1 gene_id:2657|Hs108|chr19 (372 aa) initn: 2604 init1: 2604 opt: 2604 Z-score: 2319.3 bits: 437.8 E(32554): 7.3e-123 Smith-Waterman score: 2604; 100.0% identity (100.0% similar) in 372 aa overlap (1-372:1-372) 10 20 30 40 50 60 pF1KE3 MPPPQQGPCGHHLLLLLALLLPSLPLTRAPVPPGPAAALLQALGLRDEPQGAPRLRPVPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 MPPPQQGPCGHHLLLLLALLLPSLPLTRAPVPPGPAAALLQALGLRDEPQGAPRLRPVPP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 VMWRLFRRRDPQETRSGSRRTSPGVTLQPCHVEELGVAGNIVRHIPDRGAPTRASEPASA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 VMWRLFRRRDPQETRSGSRRTSPGVTLQPCHVEELGVAGNIVRHIPDRGAPTRASEPASA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 AGHCPEWTVVFDLSAVEPAERPSRARLELRFAAAAAAAPEGGWELSVAQAGQGAGADPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 AGHCPEWTVVFDLSAVEPAERPSRARLELRFAAAAAAAPEGGWELSVAQAGQGAGADPGP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 VLLRQLVPALGPPVRAELLGAAWARNASWPRSLRLALALRPRAPAACARLAEASLLLVTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 VLLRQLVPALGPPVRAELLGAAWARNASWPRSLRLALALRPRAPAACARLAEASLLLVTL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 DPRLCHPLARPRRDAEPVLGGGPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 DPRLCHPLARPRRDAEPVLGGGPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQC 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 ALPVALSGSGGPPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 ALPVALSGSGGPPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQ 310 320 330 340 350 360 370 pF1KE3 YEDMVVDECGCR :::::::::::: CCDS42 YEDMVVDECGCR 370 >>CCDS8581.1 GDF3 gene_id:9573|Hs108|chr12 (364 aa) initn: 595 init1: 222 opt: 524 Z-score: 474.5 bits: 96.4 E(32554): 4.1e-20 Smith-Waterman score: 701; 36.8% identity (62.6% similar) in 356 aa overlap (39-371:29-363) 10 20 30 40 50 60 pF1KE3 CGHHLLLLLALLLPSLPLTRAPVPPGPAAALLQALGLRDEPQGAPRLRPVPPVMWRLFRR .:: ::: :. . ...::: .. ..:. CCDS85 MLRFLPDLAFSFLLILALGQAVQFQEYVFLQFLGL-DKAPSPQKFQPVPYILKKIFQD 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 RDPQETRSGSRRTSPGVTLQPCHVEELGVAGNIVRHIPDRG---APTRASEPASAAGHCP :. : ::. . :.:.:::: ::..: .::.: : . :. .: : CCDS85 REAAATT--------GVSRDLCYVKELGVRGNVLRFLPDQGFFLYPKKISQASS----CL 60 70 80 90 100 130 140 150 160 170 180 pF1KE3 EWTVVFDLSAVEPAERPSRARLELRFAAAA--AAAPEGGWELSVAQAGQGAGAD---PGP . . :.:::.. :. . :.: : .. . .:: : ..: . : :: CCDS85 QKLLYFNLSAIKEREQLTLAQLGLDLGPNSYYNLGPELELALFLVQEPHVWGQTTPKPGK 110 120 130 140 150 160 190 200 210 220 230 pF1KE3 VLLRQLVPALGPPVRAELLGAA--WARNASWPRSLRLALALRP--------RAPAACARL ... . :: :. .:: .: : : .: : . .. . .:::: CCDS85 MFVLRSVPWPQGAVHFNLLDVAKDWNDNPRKNFGLFLEILVKEDRDSGVNFQPEDTCARL 170 180 190 200 210 220 240 250 260 270 280 pF1KE3 A---EASLLLVTLDPRLCHPLARPRRDAEPVLGGGPGGACRARRLYVSFREVGWHRWVIA .::::.:::.: ::: .: :: : :: . . :. ..:...::..:::.:.:: CCDS85 RCSLHASLLVVTLNPDQCHP-SRKRRAAIPVPKLSCKNLCHRHQLFINFRDLGWHKWIIA 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE3 PRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMHAAAPGAADLP--CCVPARLSPI :.::.::::.:.: . ...: ... :.: ..:::::. : ..: :.:..:::: CCDS85 PKGFMANYCHGECPFSLTISLNSS----NYAFMQALMHAVDP---EIPQAVCIPTKLSPI 290 300 310 320 330 350 360 370 pF1KE3 SVLFFDNSDNVVLRQYEDMVVDECGCR :.:. ::.:::.::.::::::::::: CCDS85 SMLYQDNNDNVILRHYEDMVVDECGCG 340 350 360 >>CCDS1701.1 GDF7 gene_id:151449|Hs108|chr2 (450 aa) initn: 271 init1: 271 opt: 408 Z-score: 370.3 bits: 77.5 E(32554): 2.6e-14 Smith-Waterman score: 431; 32.8% identity (55.6% similar) in 320 aa overlap (64-372:160-450) 40 50 60 70 80 90 pF1KE3 GPAAALLQALGLRDEPQGAPRLRPVPPVMWRLFRRRDPQETRSGSRRTSPGVTLQPCHVE :..:: .: :. :: . : . :. : CCDS17 QDESAAETGQSFLFDVSSLNDADEVVGAELRVLRRGSP-ESGPGSWTSPPLLLLSTCP-- 130 140 150 160 170 180 100 110 120 130 140 pF1KE3 ELGVAGNIVRHIPDRGAPTRASEPASAAGHCPEWTVVFDLSAV------EPAERPSRAR- :.: . : : .::.:: .:. .: . ::.. . :: :: :: CCDS17 --GAA-----RAP-RLLYSRAAEPL--VGQ--RWEA-FDVADAMRRHRREP--RPPRAFC 190 200 210 220 230 150 160 170 180 190 200 pF1KE3 LELRFAAAAAAAPEGGWELSVAQAGQGAGADPGPVLLRQLVPALGPPVRAELLGAAWARN : :: .:. . .: . .:. . : :..: : .. . . : : : . . CCDS17 LLLRAVAGPVPSPLALRRLGFGWPGGGGSAAE----ERAVLVVSSRTQRKESL---FREI 240 250 260 270 280 210 220 230 240 250 260 pF1KE3 ASWPRSLRLALALRPRAPAACARLAEASLLLVTLDPRLCHPLARPRRDAEPVLGGGPG-- . :.: ::: .: . . . ... : .: . . : : : CCDS17 RAQARALGAALASEPLPDPGTGTASPRAVIGGRRRRRTALAGTRTAQGSGGGAGRGHGRR 290 300 310 320 330 340 270 280 290 300 310 320 pF1KE3 --GACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRA . : . :.:.:.:.:: :.::: . : .:.: : .:. : :. :::.... CCDS17 GRSRCSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGLCDFPLR---SHLEPT-NHAIIQT 350 360 370 380 390 400 330 340 350 360 370 pF1KE3 LMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGCR :... :: :: :::::::::::.:..: ..::: .:::::::. :::: CCDS17 LLNSMAPDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGCR 410 420 430 440 450 >>CCDS4503.1 BMP6 gene_id:654|Hs108|chr6 (513 aa) initn: 495 init1: 226 opt: 404 Z-score: 366.0 bits: 76.8 E(32554): 4.6e-14 Smith-Waterman score: 404; 47.2% identity (80.2% similar) in 106 aa overlap (266-371:411-512) 240 250 260 270 280 290 pF1KE3 LLVTLDPRLCHPLARPRRDAEPVLGGGPGGACRARRLYVSFREVGWHRWVIAPRGFLANY ::: ..:::::...::. :.:::.:. ::: CCDS45 RQQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANY 390 400 410 420 430 440 300 310 320 330 340 350 pF1KE3 CQGQCALPVALSGSGGPPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVLFFDNSDN :.:.:..:. .. : :::....:.: : . :::.:..:. ::::.::...: CCDS45 CDGECSFPL----NAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSN 450 460 470 480 490 360 370 pF1KE3 VVLRQYEDMVVDECGCR :.:..:..::: ::: CCDS45 VILKKYRNMVVRACGCH 500 510 >>CCDS13455.1 BMP7 gene_id:655|Hs108|chr20 (431 aa) initn: 476 init1: 229 opt: 402 Z-score: 365.3 bits: 76.5 E(32554): 5e-14 Smith-Waterman score: 402; 48.1% identity (80.2% similar) in 106 aa overlap (266-371:329-430) 240 250 260 270 280 290 pF1KE3 LLVTLDPRLCHPLARPRRDAEPVLGGGPGGACRARRLYVSFREVGWHRWVIAPRGFLANY ::. ..::::::..::. :.:::.:. : : CCDS13 RSQNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYY 300 310 320 330 340 350 300 310 320 330 340 350 pF1KE3 CQGQCALPVALSGSGGPPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVLFFDNSDN :.:.::.:. .. : :::....:.: : .. :::.:..:. ::::.::.:.: CCDS13 CEGECAFPL----NSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSN 360 370 380 390 400 410 360 370 pF1KE3 VVLRQYEDMVVDECGCR :.:..:..::: ::: CCDS13 VILKKYRNMVVRACGCH 420 430 >>CCDS437.1 BMP8A gene_id:353500|Hs108|chr1 (402 aa) initn: 473 init1: 228 opt: 397 Z-score: 361.3 bits: 75.6 E(32554): 8.4e-14 Smith-Waterman score: 408; 36.0% identity (60.2% similar) in 211 aa overlap (162-371:215-401) 140 150 160 170 180 190 pF1KE3 DLSAVEPAERPSRARLELRFAAAAAAAPEGGWELSVAQAGQGAGADPGPV-LLRQLVPAL : .: : .. .: ..::: . :: : .: CCDS43 QTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYV-ETEDGHSVDPGLAGLLGQRAPRS 190 200 210 220 230 240 200 210 220 230 240 250 pF1KE3 GPPVRAELLGAAWARNASWPRSLRLALALRPRAPAACARLAEASLLLVTLDPRLCHPLAR : . .. :. ::..: :: : : .: .:. : .: CCDS43 QQPFVVTFFRAS-PSPIRTPRAVR---PLRRRQPKKSNELPQANRLPGIFDD-------- 250 260 270 280 290 260 270 280 290 300 310 pF1KE3 PRRDAEPVLGGGPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSG : :. .:: ..:::::...:: :::::.:. : ::.:.:..:. . CCDS43 -------VRGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMN- 300 310 320 330 340 320 330 340 350 360 370 pF1KE3 GPPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECG : :::.:..:.: :.:. ::.:..:: :::..:.:.::.::....::: :: CCDS43 ---ATNHAILQSLVHLMKPNAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACG 350 360 370 380 390 400 pF1KE3 CR : CCDS43 CH >>CCDS444.1 BMP8B gene_id:656|Hs108|chr1 (402 aa) initn: 440 init1: 227 opt: 396 Z-score: 360.4 bits: 75.5 E(32554): 9.4e-14 Smith-Waterman score: 407; 36.0% identity (59.7% similar) in 211 aa overlap (162-371:215-401) 140 150 160 170 180 190 pF1KE3 DLSAVEPAERPSRARLELRFAAAAAAAPEGGWELSVAQAGQGAGADPGPV-LLRQLVPAL : .: : .. .: ..::: . :: : .: CCDS44 QTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYV-ETEDGHSVDPGLAGLLGQRAPRS 190 200 210 220 230 240 200 210 220 230 240 250 pF1KE3 GPPVRAELLGAAWARNASWPRSLRLALALRPRAPAACARLAEASLLLVTLDPRLCHPLAR : . .. :. ::..: :: : : .: .:. : .: CCDS44 QQPFVVTFFRAS-PSPIRTPRAVR---PLRRRQPKKSNELPQANRLPGIFDD-------- 250 260 270 280 290 260 270 280 290 300 310 pF1KE3 PRRDAEPVLGGGPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSG : :. .:: ..:::::...:: :::::.:. : ::.:.:..:. . CCDS44 -------VHGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMN- 300 310 320 330 340 320 330 340 350 360 370 pF1KE3 GPPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECG : :::.:..:.: : :. ::.:..:: :::..:.:.::.::....::: :: CCDS44 ---ATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACG 350 360 370 380 390 400 pF1KE3 CR : CCDS44 CH >>CCDS4958.1 BMP5 gene_id:653|Hs108|chr6 (454 aa) initn: 451 init1: 230 opt: 396 Z-score: 359.6 bits: 75.5 E(32554): 1e-13 Smith-Waterman score: 396; 47.2% identity (79.2% similar) in 106 aa overlap (266-371:352-453) 240 250 260 270 280 290 pF1KE3 LLVTLDPRLCHPLARPRRDAEPVLGGGPGGACRARRLYVSFREVGWHRWVIAPRGFLANY ::. ..::::::..::. :.:::.:. : : CCDS49 KNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFY 330 340 350 360 370 380 300 310 320 330 340 350 pF1KE3 CQGQCALPVALSGSGGPPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVLFFDNSDN :.:.:..:. .. : :::....:.: : . :::.:..:. ::::.::.:.: CCDS49 CDGECSFPL----NAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSN 390 400 410 420 430 360 370 pF1KE3 VVLRQYEDMVVDECGCR :.:..:..::: ::: CCDS49 VILKKYRNMVVRSCGCH 440 450 >>CCDS34926.1 GDF6 gene_id:392255|Hs108|chr8 (455 aa) initn: 434 init1: 253 opt: 385 Z-score: 349.9 bits: 73.7 E(32554): 3.6e-13 Smith-Waterman score: 385; 42.6% identity (64.7% similar) in 136 aa overlap (242-372:324-455) 220 230 240 250 260 pF1KE3 SLRLALALRPRAPAACARLAEASLLLVTLDPRLCHPLARPRRDAEPVLGGGPGGA----- : : : : :: : : : CCDS34 REQLGSAEAAGPGAGAEGSWPPPSGAPDARPWLPSPGRRRRRTAFASRHGKRHGKKSRLR 300 310 320 330 340 350 270 280 290 300 310 320 pF1KE3 CRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMHA : . :.:.:.:.:: :.::: . : .:.: : .:. : :. :::....::.. CCDS34 CSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLR---SHLEPT-NHAIIQTLMNS 360 370 380 390 400 330 340 350 360 370 pF1KE3 AAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGCR ::.. ::::..:.:::.:..: ..::: .:::::::. :::: CCDS34 MDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR 410 420 430 440 450 >>CCDS13254.1 GDF5 gene_id:8200|Hs108|chr20 (501 aa) initn: 433 init1: 257 opt: 375 Z-score: 340.4 bits: 72.1 E(32554): 1.2e-12 Smith-Waterman score: 406; 29.6% identity (49.6% similar) in 423 aa overlap (2-372:106-501) 10 20 30 pF1KE3 MPPPQQGPCGHHLLLLLALLLPSLPLTRAPV : : . : .. . .:: .:: CCDS13 AKGGTGQTGGLTQPKKDEPKKLPPRPGGPEPKPGHPPQTRQATARTVTPKGQLPGGKAPP 80 90 100 110 120 130 40 50 60 70 80 pF1KE3 PPG--PAAALLQAL---GLRDEPQGAPRLRPVPP--VMWRLFRRRDPQETRSGSRRTSPG : :.. ::. : ::. : :. : : :.: . . ..: . . CCDS13 KAGSVPSSFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGG----NSS 140 150 160 170 180 190 90 100 110 120 130 140 pF1KE3 VTLQPCHVEELGVAGNIVRHIPDRGAPTRASEPASAAGHCPEWTVVFDLSAVEPAERPSR : : : :.:..:. : :.: :. :. . :::.::. :. . CCDS13 VKL------EAGLANTITSFI-DKGQDDRG--PVVR-----KQRYVFDISAL---EKDGL 200 210 220 230 150 160 170 180 190 pF1KE3 ARLELRFA------AAAAAAPEGGWELSVAQAGQGAGADPGPVLLRQLVPALGPPVRAEL :::. .: ::: :: .. .. .: .:. .: . ::.: :. CCDS13 LGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVPGLDGS-GWEV 240 250 260 270 280 290 200 210 220 230 240 pF1KE3 LGAAWARNASWPRSLRLALAL----RPRA--------PAACARLAEASLLLV-----TLD . : .. : .: : : : :: : .. : .:.:: : CCDS13 FDI-WKLFRNFKNSAQLCLELEAWERGRAVDLRGLGFDRAARQVHEKALFLVFGRTKKRD 300 310 320 330 340 350 250 260 270 pF1KE3 PRLCHPLARPRRDAEPVL------------------GGGPG----GACRARRLYVSFREV . . :: .: . : : :. . : . :.:.:... CCDS13 LFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDM 360 370 380 390 400 410 280 290 300 310 320 330 pF1KE3 GWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMHAAAPGAADLPCCVP :: :.::: . : .:.: : .:. : :. ::::...::.. : .. :::: CCDS13 GWDDWIIAPLEYEAFHCEGLCEFPLR---SHLEPT-NHAVIQTLMNSMDPESTPPTCCVP 420 430 440 450 460 340 350 360 370 pF1KE3 ARLSPISVLFFDNSDNVVLRQYEDMVVDECGCR .::::::.::.:...::: .:::::::. :::: CCDS13 TRLSPISILFIDSANNVVYKQYEDMVVESCGCR 470 480 490 500 372 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 19:07:30 2016 done: Mon Nov 7 19:07:30 2016 Total Scan time: 3.170 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]