Result of FASTA (omim) for
pFN21AE3238
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3238, 532 aa
1>>>pF1KE3238 532 - 532 aa - 532 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3023+/-0.000327; mu= 18.7006+/- 0.021
mean_var=66.0946+/-13.553, 0's: 0 Z-trim(115.3): 26 B-trim: 430 in 1/51
Lambda= 0.157758
statistics sampled from 25676 (25702) to 25676 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.665), E-opt: 0.2 (0.301), width: 16
Scan time: 9.070
The best scores are: opt bits E(85289)
NP_963842 (OMIM: 608380,608381) ceramide kinase-li ( 532) 3558 818.6 0
NP_001153749 (OMIM: 608380,608381) ceramide kinase ( 514) 2054 476.3 9.6e-134
NP_001025482 (OMIM: 608380,608381) ceramide kinase ( 558) 2054 476.3 1e-133
NP_001025483 (OMIM: 608380,608381) ceramide kinase ( 419) 1759 409.1 1.3e-113
NP_001025484 (OMIM: 608380,608381) ceramide kinase ( 463) 1749 406.9 6.9e-113
NP_073603 (OMIM: 610307) ceramide kinase [Homo sap ( 537) 532 129.9 1.9e-29
XP_016884398 (OMIM: 610307) PREDICTED: ceramide ki ( 500) 516 126.3 2.2e-28
XP_005250080 (OMIM: 212350,610345,614691) PREDICTE ( 350) 217 58.1 5e-08
XP_011514699 (OMIM: 212350,610345,614691) PREDICTE ( 422) 217 58.2 5.9e-08
NP_060708 (OMIM: 212350,610345,614691) acylglycero ( 422) 217 58.2 5.9e-08
XP_005257823 (OMIM: 603730) PREDICTED: sphingosine ( 384) 199 54.1 9.3e-07
NP_001136074 (OMIM: 603730) sphingosine kinase 1 i ( 384) 199 54.1 9.3e-07
NP_001136073 (OMIM: 603730) sphingosine kinase 1 i ( 384) 199 54.1 9.3e-07
NP_068807 (OMIM: 603730) sphingosine kinase 1 isof ( 398) 199 54.1 9.6e-07
NP_892010 (OMIM: 603730) sphingosine kinase 1 isof ( 470) 199 54.1 1.1e-06
NP_001191087 (OMIM: 607092) sphingosine kinase 2 i ( 595) 198 53.9 1.6e-06
XP_006723355 (OMIM: 607092) PREDICTED: sphingosine ( 618) 198 53.9 1.6e-06
NP_001191089 (OMIM: 607092) sphingosine kinase 2 i ( 618) 198 53.9 1.6e-06
XP_011525436 (OMIM: 607092) PREDICTED: sphingosine ( 618) 198 53.9 1.6e-06
XP_011525435 (OMIM: 607092) PREDICTED: sphingosine ( 654) 198 54.0 1.7e-06
NP_001191088 (OMIM: 607092) sphingosine kinase 2 i ( 654) 198 54.0 1.7e-06
NP_064511 (OMIM: 607092) sphingosine kinase 2 isof ( 654) 198 54.0 1.7e-06
XP_016882497 (OMIM: 607092) PREDICTED: sphingosine ( 716) 198 54.0 1.8e-06
XP_016882499 (OMIM: 607092) PREDICTED: sphingosine ( 401) 153 43.6 0.0014
XP_016882498 (OMIM: 607092) PREDICTED: sphingosine ( 448) 151 43.2 0.0021
NP_001230805 (OMIM: 607092) sphingosine kinase 2 i ( 448) 151 43.2 0.0021
>>NP_963842 (OMIM: 608380,608381) ceramide kinase-like p (532 aa)
initn: 3558 init1: 3558 opt: 3558 Z-score: 4371.9 bits: 818.6 E(85289): 0
Smith-Waterman score: 3558; 100.0% identity (100.0% similar) in 532 aa overlap (1-532:1-532)
10 20 30 40 50 60
pF1KE3 MPWRRRRNRVSALEGGREEEAPPEAAAVPPALLTSPQQTEAAAERILLRGIFEIGRDSCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 MPWRRRRNRVSALEGGREEEAPPEAAAVPPALLTSPQQTEAAAERILLRGIFEIGRDSCD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 VVLSERALRWRPIQPERPAGDSKYDLLCKEEFIELKDIFSVKLKRRCSVKQQRSGTLLGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 VVLSERALRWRPIQPERPAGDSKYDLLCKEEFIELKDIFSVKLKRRCSVKQQRSGTLLGI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 TLFICLKKEQNKLKNSTLDLINLSEDHCDIWFRQFKKILAGFPNRPKSLKILLNPQSHKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 TLFICLKKEQNKLKNSTLDLINLSEDHCDIWFRQFKKILAGFPNRPKSLKILLNPQSHKK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 EATQVYYEKVEPLLKLAGIKTDVTIMEYEGHALSLLKECELQGFDGVVCVGGDGSASEVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 EATQVYYEKVEPLLKLAGIKTDVTIMEYEGHALSLLKECELQGFDGVVCVGGDGSASEVA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 HALLLRAQKNAGMETDRILTPVRAQLPLGLIPAGSTNVLAHSLHGVPHVITATLHIIMGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 HALLLRAQKNAGMETDRILTPVRAQLPLGLIPAGSTNVLAHSLHGVPHVITATLHIIMGH
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 VQLVDVCTFSTAGKLLRFGFSAMFGFGGRTLALAEKYRWMSPNQRRDFAVVKALAKLKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 VQLVDVCTFSTAGKLLRFGFSAMFGFGGRTLALAEKYRWMSPNQRRDFAVVKALAKLKAE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 DCEISFLPFNSSDDVQERRAQGSPKSDCNDQWQMIQGQFLNVSIMAIPCLCSVAPRGLAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 DCEISFLPFNSSDDVQERRAQGSPKSDCNDQWQMIQGQFLNVSIMAIPCLCSVAPRGLAP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 NTRLNNGSMALIIARNTSRPEFIKHLKRYASVKNQFNFPFVETYTVEEVKVHPRNNTGGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 NTRLNNGSMALIIARNTSRPEFIKHLKRYASVKNQFNFPFVETYTVEEVKVHPRNNTGGY
430 440 450 460 470 480
490 500 510 520 530
pF1KE3 NPEEEEDETASENCFPWNVDGDLMEVASEVHIRLHPRLISLYGGSMEEMIPK
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 NPEEEEDETASENCFPWNVDGDLMEVASEVHIRLHPRLISLYGGSMEEMIPK
490 500 510 520 530
>>NP_001153749 (OMIM: 608380,608381) ceramide kinase-lik (514 aa)
initn: 3115 init1: 2054 opt: 2054 Z-score: 2522.1 bits: 476.3 E(85289): 9.6e-134
Smith-Waterman score: 3114; 87.3% identity (87.5% similar) in 558 aa overlap (1-532:1-514)
10 20 30 40 50 60
pF1KE3 MPWRRRRNRVSALEGGREEEAPPEAAAVPPALLTSPQQTEAAAERILLRGIFEIGRDSCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPWRRRRNRVSALEGGREEEAPPEAAAVPPALLTSPQQTEAAAERILLRGIFEIGRDSCD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 VVLSERALRWRPIQPERPAGDSKYDLLCKEEFIELKDIFSVKLKRRCSVKQQRSGTLLGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVLSERALRWRPIQPERPAGDSKYDLLCKEEFIELKDIFSVKLKRRCSVKQQRSGTLLGI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 TLFICLKKEQNKLKNSTLDLINLSEDHCDIWFRQFKKILAGFPNRPKSLKILLNPQSHKK
::::::::::::::::::::::::::::::::::::::::
NP_001 TLFICLKKEQNKLKNSTLDLINLSEDHCDIWFRQFKKILA--------------------
130 140 150 160
190 200 210 220
pF1KE3 EATQVYYEKVEPLLKLAGIKTDVTIMEYEGHALSLLKECELQGFDG--------------
.:::::::::::::::::::::
NP_001 ------------------------VMEYEGHALSLLKECELQGFDGGHRKPLFAIHWSVQ
170 180 190
230 240 250 260 270
pF1KE3 ------------VVCVGGDGSASEVAHALLLRAQKNAGMETDRILTPVRAQLPLGLIPAG
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLFTGMQTLEPSVVCVGGDGSASEVAHALLLRAQKNAGMETDRILTPVRAQLPLGLIPAG
200 210 220 230 240 250
280 290 300 310 320 330
pF1KE3 STNVLAHSLHGVPHVITATLHIIMGHVQLVDVCTFSTAGKLLRFGFSAMFGFGGRTLALA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STNVLAHSLHGVPHVITATLHIIMGHVQLVDVCTFSTAGKLLRFGFSAMFGFGGRTLALA
260 270 280 290 300 310
340 350 360 370 380 390
pF1KE3 EKYRWMSPNQRRDFAVVKALAKLKAEDCEISFLPFNSSDDVQERRAQGSPKSDCNDQWQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKYRWMSPNQRRDFAVVKALAKLKAEDCEISFLPFNSSDDVQERRAQGSPKSDCNDQWQM
320 330 340 350 360 370
400 410 420 430 440 450
pF1KE3 IQGQFLNVSIMAIPCLCSVAPRGLAPNTRLNNGSMALIIARNTSRPEFIKHLKRYASVKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IQGQFLNVSIMAIPCLCSVAPRGLAPNTRLNNGSMALIIARNTSRPEFIKHLKRYASVKN
380 390 400 410 420 430
460 470 480 490 500 510
pF1KE3 QFNFPFVETYTVEEVKVHPRNNTGGYNPEEEEDETASENCFPWNVDGDLMEVASEVHIRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QFNFPFVETYTVEEVKVHPRNNTGGYNPEEEEDETASENCFPWNVDGDLMEVASEVHIRL
440 450 460 470 480 490
520 530
pF1KE3 HPRLISLYGGSMEEMIPK
::::::::::::::::::
NP_001 HPRLISLYGGSMEEMIPK
500 510
>>NP_001025482 (OMIM: 608380,608381) ceramide kinase-lik (558 aa)
initn: 3544 init1: 2054 opt: 2054 Z-score: 2521.6 bits: 476.3 E(85289): 1e-133
Smith-Waterman score: 3496; 95.3% identity (95.3% similar) in 558 aa overlap (1-532:1-558)
10 20 30 40 50 60
pF1KE3 MPWRRRRNRVSALEGGREEEAPPEAAAVPPALLTSPQQTEAAAERILLRGIFEIGRDSCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPWRRRRNRVSALEGGREEEAPPEAAAVPPALLTSPQQTEAAAERILLRGIFEIGRDSCD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 VVLSERALRWRPIQPERPAGDSKYDLLCKEEFIELKDIFSVKLKRRCSVKQQRSGTLLGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVLSERALRWRPIQPERPAGDSKYDLLCKEEFIELKDIFSVKLKRRCSVKQQRSGTLLGI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 TLFICLKKEQNKLKNSTLDLINLSEDHCDIWFRQFKKILAGFPNRPKSLKILLNPQSHKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLFICLKKEQNKLKNSTLDLINLSEDHCDIWFRQFKKILAGFPNRPKSLKILLNPQSHKK
130 140 150 160 170 180
190 200 210 220
pF1KE3 EATQVYYEKVEPLLKLAGIKTDVTIMEYEGHALSLLKECELQGFDG--------------
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EATQVYYEKVEPLLKLAGIKTDVTIMEYEGHALSLLKECELQGFDGGHRKPLFAIHWSVQ
190 200 210 220 230 240
230 240 250 260 270
pF1KE3 ------------VVCVGGDGSASEVAHALLLRAQKNAGMETDRILTPVRAQLPLGLIPAG
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLFTGMQTLEPSVVCVGGDGSASEVAHALLLRAQKNAGMETDRILTPVRAQLPLGLIPAG
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE3 STNVLAHSLHGVPHVITATLHIIMGHVQLVDVCTFSTAGKLLRFGFSAMFGFGGRTLALA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STNVLAHSLHGVPHVITATLHIIMGHVQLVDVCTFSTAGKLLRFGFSAMFGFGGRTLALA
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE3 EKYRWMSPNQRRDFAVVKALAKLKAEDCEISFLPFNSSDDVQERRAQGSPKSDCNDQWQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKYRWMSPNQRRDFAVVKALAKLKAEDCEISFLPFNSSDDVQERRAQGSPKSDCNDQWQM
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE3 IQGQFLNVSIMAIPCLCSVAPRGLAPNTRLNNGSMALIIARNTSRPEFIKHLKRYASVKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IQGQFLNVSIMAIPCLCSVAPRGLAPNTRLNNGSMALIIARNTSRPEFIKHLKRYASVKN
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE3 QFNFPFVETYTVEEVKVHPRNNTGGYNPEEEEDETASENCFPWNVDGDLMEVASEVHIRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QFNFPFVETYTVEEVKVHPRNNTGGYNPEEEEDETASENCFPWNVDGDLMEVASEVHIRL
490 500 510 520 530 540
520 530
pF1KE3 HPRLISLYGGSMEEMIPK
::::::::::::::::::
NP_001 HPRLISLYGGSMEEMIPK
550
>>NP_001025483 (OMIM: 608380,608381) ceramide kinase-lik (419 aa)
initn: 1807 init1: 1759 opt: 1759 Z-score: 2160.6 bits: 409.1 E(85289): 1.3e-113
Smith-Waterman score: 2588; 78.8% identity (78.8% similar) in 532 aa overlap (1-532:1-419)
10 20 30 40 50 60
pF1KE3 MPWRRRRNRVSALEGGREEEAPPEAAAVPPALLTSPQQTEAAAERILLRGIFEIGRDSCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPWRRRRNRVSALEGGREEEAPPEAAAVPPALLTSPQQTEAAAERILLRGIFEIGRDSCD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 VVLSERALRWRPIQPERPAGDSKYDLLCKEEFIELKDIFSVKLKRRCSVKQQRSGTLLGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVLSERALRWRPIQPERPAGDSKYDLLCKEEFIELKDIFSVKLKRRCSVKQQRSGTLLGI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 TLFICLKKEQNKLKNSTLDLINLSEDHCDIWFRQFKKILAGFPNRPKSLKILLNPQSHKK
:::::::::::::::::::::::::::::::::::::::::
NP_001 TLFICLKKEQNKLKNSTLDLINLSEDHCDIWFRQFKKILAG-------------------
130 140 150 160
190 200 210 220 230 240
pF1KE3 EATQVYYEKVEPLLKLAGIKTDVTIMEYEGHALSLLKECELQGFDGVVCVGGDGSASEVA
NP_001 ------------------------------------------------------------
250 260 270 280 290 300
pF1KE3 HALLLRAQKNAGMETDRILTPVRAQLPLGLIPAGSTNVLAHSLHGVPHVITATLHIIMGH
::::::::::::::::::::::::::
NP_001 ----------------------------------STNVLAHSLHGVPHVITATLHIIMGH
170 180
310 320 330 340 350 360
pF1KE3 VQLVDVCTFSTAGKLLRFGFSAMFGFGGRTLALAEKYRWMSPNQRRDFAVVKALAKLKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQLVDVCTFSTAGKLLRFGFSAMFGFGGRTLALAEKYRWMSPNQRRDFAVVKALAKLKAE
190 200 210 220 230 240
370 380 390 400 410 420
pF1KE3 DCEISFLPFNSSDDVQERRAQGSPKSDCNDQWQMIQGQFLNVSIMAIPCLCSVAPRGLAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DCEISFLPFNSSDDVQERRAQGSPKSDCNDQWQMIQGQFLNVSIMAIPCLCSVAPRGLAP
250 260 270 280 290 300
430 440 450 460 470 480
pF1KE3 NTRLNNGSMALIIARNTSRPEFIKHLKRYASVKNQFNFPFVETYTVEEVKVHPRNNTGGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NTRLNNGSMALIIARNTSRPEFIKHLKRYASVKNQFNFPFVETYTVEEVKVHPRNNTGGY
310 320 330 340 350 360
490 500 510 520 530
pF1KE3 NPEEEEDETASENCFPWNVDGDLMEVASEVHIRLHPRLISLYGGSMEEMIPK
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPEEEEDETASENCFPWNVDGDLMEVASEVHIRLHPRLISLYGGSMEEMIPK
370 380 390 400 410
>>NP_001025484 (OMIM: 608380,608381) ceramide kinase-lik (463 aa)
initn: 3085 init1: 1745 opt: 1749 Z-score: 2147.6 bits: 406.9 E(85289): 6.9e-113
Smith-Waterman score: 2948; 87.0% identity (87.0% similar) in 532 aa overlap (1-532:1-463)
10 20 30 40 50 60
pF1KE3 MPWRRRRNRVSALEGGREEEAPPEAAAVPPALLTSPQQTEAAAERILLRGIFEIGRDSCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPWRRRRNRVSALEGGREEEAPPEAAAVPPALLTSPQQTEAAAERILLRGIFEIGRDSCD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 VVLSERALRWRPIQPERPAGDSKYDLLCKEEFIELKDIFSVKLKRRCSVKQQRSGTLLGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVLSERALRWRPIQPERPAGDSKYDLLCKEEFIELKDIFSVKLKRRCSVKQQRSGTLLGI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 TLFICLKKEQNKLKNSTLDLINLSEDHCDIWFRQFKKILAGFPNRPKSLKILLNPQSHKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLFICLKKEQNKLKNSTLDLINLSEDHCDIWFRQFKKILAGFPNRPKSLKILLNPQSHKK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 EATQVYYEKVEPLLKLAGIKTDVTIMEYEGHALSLLKECELQGFDGVVCVGGDGSASEVA
::::::::::::::::::::::::
NP_001 EATQVYYEKVEPLLKLAGIKTDVT------------------------------------
190 200
250 260 270 280 290 300
pF1KE3 HALLLRAQKNAGMETDRILTPVRAQLPLGLIPAGSTNVLAHSLHGVPHVITATLHIIMGH
: ::::::::::::::::::::::::::
NP_001 -----R----------------------------STNVLAHSLHGVPHVITATLHIIMGH
210 220 230
310 320 330 340 350 360
pF1KE3 VQLVDVCTFSTAGKLLRFGFSAMFGFGGRTLALAEKYRWMSPNQRRDFAVVKALAKLKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQLVDVCTFSTAGKLLRFGFSAMFGFGGRTLALAEKYRWMSPNQRRDFAVVKALAKLKAE
240 250 260 270 280 290
370 380 390 400 410 420
pF1KE3 DCEISFLPFNSSDDVQERRAQGSPKSDCNDQWQMIQGQFLNVSIMAIPCLCSVAPRGLAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DCEISFLPFNSSDDVQERRAQGSPKSDCNDQWQMIQGQFLNVSIMAIPCLCSVAPRGLAP
300 310 320 330 340 350
430 440 450 460 470 480
pF1KE3 NTRLNNGSMALIIARNTSRPEFIKHLKRYASVKNQFNFPFVETYTVEEVKVHPRNNTGGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NTRLNNGSMALIIARNTSRPEFIKHLKRYASVKNQFNFPFVETYTVEEVKVHPRNNTGGY
360 370 380 390 400 410
490 500 510 520 530
pF1KE3 NPEEEEDETASENCFPWNVDGDLMEVASEVHIRLHPRLISLYGGSMEEMIPK
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPEEEEDETASENCFPWNVDGDLMEVASEVHIRLHPRLISLYGGSMEEMIPK
420 430 440 450 460
>>NP_073603 (OMIM: 610307) ceramide kinase [Homo sapiens (537 aa)
initn: 639 init1: 267 opt: 532 Z-score: 649.7 bits: 129.9 E(85289): 1.9e-29
Smith-Waterman score: 748; 28.5% identity (59.6% similar) in 527 aa overlap (48-527:10-528)
20 30 40 50 60 70
pF1KE3 EEEAPPEAAAVPPALLTSPQQTEAAAERILLRGIFEIGRDSCDVVLSE-RAL-RWRPIQP
:.... . .. : : : ::: :: .:
NP_073 MGATGAAEPLQSVLWVKQQRCAVSLEPARALLRWWR-SP
10 20 30
80 90 100 110 120 130
pF1KE3 ERPAGDSKYDLLCK---EEFIELKDIFSVKLKRRCSVKQQRSGTLLGITLFICLKK-EQN
:: : :. :.: ... .:. :.. : : :. ..:. :.:. ...
NP_073 GPGAGAPGADA-CSVPVSEIIAVEET-DVHGKHQGSGKWQKMEKPYAFTVH-CVKRARRH
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE3 KLKNSTLDLINLSEDHCDIWFRQFKKILAGFPNRPKSLKILLNPQSHKKEATQVYYEKVE
. : . . . :. : .:.. ....: . .::: : ...:: . : .. ..: .::
NP_073 RWKWAQVTFWCPEEQLCHLWLQTLREMLEKLTSRPKHLLVFINPFGGKGQGKRIYERKVA
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE3 PLLKLAGIKTDVTIMEYEGHALSLLKECELQGFDGVVCVGGDGSASEVAHALLLRAQKNA
::. ::.: ::. . :. ..: : : ... .::.::::::: ::: :.:. :.:..:
NP_073 PLFTLASITTDIIVTEHANQAKETLYEINIDKYDGIVCVGGDGMFSEVLHGLIGRTQRSA
160 170 180 190 200 210
260 270 280 290 300
pF1KE3 GMETDR---ILTPVRAQLPLGLIPAGSTNVLAHSLHGVPHVITATLHIIMGHVQLVDVCT
:.. .. .:.: ..: .:.::::::. . .: :. . :..:::..: .:: .
NP_073 GVDQNHPRAVLVP--SSLRIGIIPAGSTDCVCYSTVGTSDAETSALHIVVGDSLAMDVSS
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE3 FSTAGKLLRFGFSAM-FGFGGRTLALAEKYRWMSPNQRRDFAVVKALAKLKAEDCEISFL
. :::.. : . .:: : . .:: ::.. : ::. .:.. . . . .:::
NP_073 VHHNSTLLRYSVSLLGYGFYGDIIKDSEKKRWLGLA-RYDFSGLKTFLSHHCYEGTVSFL
280 290 300 310 320 330
370 380 390 400
pF1KE3 PFNSS------------------------DDVQERRAQGSPKSDCNDQWQMIQGQFLNVS
: . . .. :.. : .. ..::.. :.:: ..
NP_073 PAQHTVGSPRDRKPCRAGCFVCRQSKQQLEEEQKKALYGLEAAEDVEEWQVVCGKFLAIN
340 350 360 370 380 390
410 420 430 440 450 460
pF1KE3 IMAIPCLCSVAPRGLAPNTRLNNGSMALIIARNTSRPEFIKHLKRYASVKNQFNFPFVET
. : : .::::.: ..:..:: ::. :. :: .:.. : :... ..::.: :::.
NP_073 ATNMSCACRRSPRGLSPAAHLGDGSSDLILIRKCSRFNFLRFLIRHTNQQDQFDFTFVEV
400 410 420 430 440 450
470 480 490 500 510
pF1KE3 YTVEEVKVHPRNNTGGYNPEEEEDE-------TASENCF------PWNVDGDLMEVASEV
: :.. . .. . .: . .. .: :: ::.... . .
NP_073 YRVKKFQFTSKHMEDEDSDLKEGGKKRFGHICSSHPSCCCTVSNSSWNCDGEVLH-SPAI
460 470 480 490 500 510
520 530
pF1KE3 HIRLHPRLISLYGGSMEEMIPK
..:.: .:. :.. ..:
NP_073 EVRVHCQLVRLFARGIEENPKPDSHS
520 530
>>XP_016884398 (OMIM: 610307) PREDICTED: ceramide kinase (500 aa)
initn: 639 init1: 267 opt: 516 Z-score: 630.5 bits: 126.3 E(85289): 2.2e-28
Smith-Waterman score: 732; 28.0% identity (60.0% similar) in 497 aa overlap (73-527:1-491)
50 60 70 80 90 100
pF1KE3 AERILLRGIFEIGRDSCDVVLSERALRWRPIQPERPAGDSKYDLLCKEEFIELKDIFSVK
. : :.:. . :.: ... .:.
XP_016 MTPLDPVGSRDACSVPVSEIIAVEET-DVH
10 20
110 120 130 140 150 160
pF1KE3 LKRRCSVKQQRSGTLLGITLFICLKK-EQNKLKNSTLDLINLSEDHCDIWFRQFKKILAG
:.. : : :. ..:. :.:. .... : . . . :. : .:.. ....:
XP_016 GKHQGSGKWQKMEKPYAFTVH-CVKRARRHRWKWAQVTFWCPEEQLCHLWLQTLREMLEK
30 40 50 60 70 80
170 180 190 200 210 220
pF1KE3 FPNRPKSLKILLNPQSHKKEATQVYYEKVEPLLKLAGIKTDVTIMEYEGHALSLLKECEL
. .::: : ...:: . : .. ..: .:: ::. ::.: ::. . :. ..: : : ..
XP_016 LTSRPKHLLVFINPFGGKGQGKRIYERKVAPLFTLASITTDIIVTEHANQAKETLYEINI
90 100 110 120 130 140
230 240 250 260 270
pF1KE3 QGFDGVVCVGGDGSASEVAHALLLRAQKNAGMETDR---ILTPVRAQLPLGLIPAGSTNV
. .::.::::::: ::: :.:. :.:..::.. .. .:.: ..: .:.::::::.
XP_016 DKYDGIVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHPRAVLVP--SSLRIGIIPAGSTDC
150 160 170 180 190 200
280 290 300 310 320 330
pF1KE3 LAHSLHGVPHVITATLHIIMGHVQLVDVCTFSTAGKLLRFGFSAM-FGFGGRTLALAEKY
. .: :. . :..:::..: .:: . . :::.. : . .:: : . .::
XP_016 VCYSTVGTSDAETSALHIVVGDSLAMDVSSVHHNSTLLRYSVSLLGYGFYGDIIKDSEKK
210 220 230 240 250 260
340 350 360 370
pF1KE3 RWMSPNQRRDFAVVKALAKLKAEDCEISFLPFNSS------------------------D
::.. : ::. .:.. . . . .:::: . . .
XP_016 RWLGLA-RYDFSGLKTFLSHHCYEGTVSFLPAQHTVGSPRDRKPCRAGCFVCRQSKQQLE
270 280 290 300 310 320
380 390 400 410 420 430
pF1KE3 DVQERRAQGSPKSDCNDQWQMIQGQFLNVSIMAIPCLCSVAPRGLAPNTRLNNGSMALII
. :.. : .. ..::.. :.:: .. . : : .::::.: ..:..:: ::.
XP_016 EEQKKALYGLEAAEDVEEWQVVCGKFLAINATNMSCACRRSPRGLSPAAHLGDGSSDLIL
330 340 350 360 370 380
440 450 460 470 480
pF1KE3 ARNTSRPEFIKHLKRYASVKNQFNFPFVETYTVEEVKVHPRNNTGGYNPEEEEDE-----
:. :: .:.. : :... ..::.: :::.: :.. . .. . .: .
XP_016 IRKCSRFNFLRFLIRHTNQQDQFDFTFVEVYRVKKFQFTSKHMEDEDSDLKEGGKKRFGH
390 400 410 420 430 440
490 500 510 520 530
pF1KE3 --TASENCF------PWNVDGDLMEVASEVHIRLHPRLISLYGGSMEEMIPK
.. .: :: ::.... . ...:.: .:. :.. ..:
XP_016 ICSSHPSCCCTVSNSSWNCDGEVLH-SPAIEVRVHCQLVRLFARGIEENPKPDSHS
450 460 470 480 490 500
>>XP_005250080 (OMIM: 212350,610345,614691) PREDICTED: a (350 aa)
initn: 218 init1: 99 opt: 217 Z-score: 265.1 bits: 58.1 E(85289): 5e-08
Smith-Waterman score: 235; 27.1% identity (60.5% similar) in 210 aa overlap (147-342:33-229)
120 130 140 150 160
pF1KE3 LLGITLFICLKKEQNKLKNSTLDLINLSEDHCDIWFR----QFKKILAGF---PN-RPKS
::: .: : ..... :: . :.
XP_005 VFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQVKK
10 20 30 40 50 60
170 180 190 200 210 220
pF1KE3 LKILLNPQSHKKEATQVYYEKVEPLLKLAGIKTDVTIMEYEGHALSLLKECELQGFDGVV
..::: . : .: .. ... :.:.:.:. . .. .:::.: .::. ... : ..
XP_005 ATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLE--LMENTDVII
70 80 90 100 110 120
230 240 250 260 270 280
pF1KE3 CVGGDGSASEVAHALLLRAQKNAGMETDRILTPVRAQLPLGLIPAGSTNVLAHSLHG---
.::::. .::. ..: : ::. . ...:.:.:: : :. :.:.: .
XP_005 VAGGDGTLQEVVTGVLRR--------TDEA---TFSKIPIGFIPLGETSSLSHTLFAESG
130 140 150 160
290 300 310 320 330 340
pF1KE3 --VPHVITATLHIIMGHVQLVDVCTFSTAGKLLRFGFSAMFGFGGRTLAL-AEKYRWMSP
: :. ::: :. :.. .:: .. . :..... . : .. . :: ...:
XP_005 NKVQHITDATLAIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGP
170 180 190 200 210 220
350 360 370 380 390 400
pF1KE3 NQRRDFAVVKALAKLKAEDCEISFLPFNSSDDVQERRAQGSPKSDCNDQWQMIQGQFLNV
XP_005 LKIKAAHFFSTLKEWPQTHQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQ
230 240 250 260 270 280
>>XP_011514699 (OMIM: 212350,610345,614691) PREDICTED: a (422 aa)
initn: 218 init1: 99 opt: 217 Z-score: 263.8 bits: 58.2 E(85289): 5.9e-08
Smith-Waterman score: 235; 27.1% identity (60.5% similar) in 210 aa overlap (147-342:33-229)
120 130 140 150 160
pF1KE3 LLGITLFICLKKEQNKLKNSTLDLINLSEDHCDIWFR----QFKKILAGF---PN-RPKS
::: .: : ..... :: . :.
XP_011 VFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQVKK
10 20 30 40 50 60
170 180 190 200 210 220
pF1KE3 LKILLNPQSHKKEATQVYYEKVEPLLKLAGIKTDVTIMEYEGHALSLLKECELQGFDGVV
..::: . : .: .. ... :.:.:.:. . .. .:::.: .::. ... : ..
XP_011 ATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLE--LMENTDVII
70 80 90 100 110 120
230 240 250 260 270 280
pF1KE3 CVGGDGSASEVAHALLLRAQKNAGMETDRILTPVRAQLPLGLIPAGSTNVLAHSLHG---
.::::. .::. ..: : ::. . ...:.:.:: : :. :.:.: .
XP_011 VAGGDGTLQEVVTGVLRR--------TDEA---TFSKIPIGFIPLGETSSLSHTLFAESG
130 140 150 160
290 300 310 320 330 340
pF1KE3 --VPHVITATLHIIMGHVQLVDVCTFSTAGKLLRFGFSAMFGFGGRTLAL-AEKYRWMSP
: :. ::: :. :.. .:: .. . :..... . : .. . :: ...:
XP_011 NKVQHITDATLAIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGP
170 180 190 200 210 220
350 360 370 380 390 400
pF1KE3 NQRRDFAVVKALAKLKAEDCEISFLPFNSSDDVQERRAQGSPKSDCNDQWQMIQGQFLNV
XP_011 LKIKAAHFFSTLKEWPQTHQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQ
230 240 250 260 270 280
>>NP_060708 (OMIM: 212350,610345,614691) acylglycerol ki (422 aa)
initn: 218 init1: 99 opt: 217 Z-score: 263.8 bits: 58.2 E(85289): 5.9e-08
Smith-Waterman score: 235; 27.1% identity (60.5% similar) in 210 aa overlap (147-342:33-229)
120 130 140 150 160
pF1KE3 LLGITLFICLKKEQNKLKNSTLDLINLSEDHCDIWFR----QFKKILAGF---PN-RPKS
::: .: : ..... :: . :.
NP_060 VFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQVKK
10 20 30 40 50 60
170 180 190 200 210 220
pF1KE3 LKILLNPQSHKKEATQVYYEKVEPLLKLAGIKTDVTIMEYEGHALSLLKECELQGFDGVV
..::: . : .: .. ... :.:.:.:. . .. .:::.: .::. ... : ..
NP_060 ATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLE--LMENTDVII
70 80 90 100 110 120
230 240 250 260 270 280
pF1KE3 CVGGDGSASEVAHALLLRAQKNAGMETDRILTPVRAQLPLGLIPAGSTNVLAHSLHG---
.::::. .::. ..: : ::. . ...:.:.:: : :. :.:.: .
NP_060 VAGGDGTLQEVVTGVLRR--------TDEA---TFSKIPIGFIPLGETSSLSHTLFAESG
130 140 150 160
290 300 310 320 330 340
pF1KE3 --VPHVITATLHIIMGHVQLVDVCTFSTAGKLLRFGFSAMFGFGGRTLAL-AEKYRWMSP
: :. ::: :. :.. .:: .. . :..... . : .. . :: ...:
NP_060 NKVQHITDATLAIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGP
170 180 190 200 210 220
350 360 370 380 390 400
pF1KE3 NQRRDFAVVKALAKLKAEDCEISFLPFNSSDDVQERRAQGSPKSDCNDQWQMIQGQFLNV
NP_060 LKIKAAHFFSTLKEWPQTHQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQ
230 240 250 260 270 280
532 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 18:59:45 2016 done: Mon Nov 7 18:59:46 2016
Total Scan time: 9.070 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]