FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3252, 588 aa 1>>>pF1KE3252 588 - 588 aa - 588 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5009+/-0.000414; mu= 19.8215+/- 0.026 mean_var=95.3417+/-18.756, 0's: 0 Z-trim(113.1): 46 B-trim: 0 in 0/54 Lambda= 0.131351 statistics sampled from 22236 (22280) to 22236 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.619), E-opt: 0.2 (0.261), width: 16 Scan time: 8.140 The best scores are: opt bits E(85289) NP_057700 (OMIM: 607421,610852) thioredoxin domain ( 588) 3815 733.7 4e-211 XP_005272156 (OMIM: 603575) PREDICTED: nucleoside ( 148) 311 69.1 1.1e-11 XP_006714779 (OMIM: 603575) PREDICTED: nucleoside ( 149) 307 68.4 1.9e-11 NP_003542 (OMIM: 603575) nucleoside diphosphate ki ( 212) 305 68.2 3.2e-11 XP_016865434 (OMIM: 603575) PREDICTED: nucleoside ( 278) 305 68.3 3.9e-11 NP_001295355 (OMIM: 608294) nucleoside diphosphate ( 186) 275 62.4 1.5e-09 NP_001295357 (OMIM: 608294) nucleoside diphosphate ( 186) 275 62.4 1.5e-09 NP_001295356 (OMIM: 608294) nucleoside diphosphate ( 186) 275 62.4 1.5e-09 XP_016861003 (OMIM: 608294) PREDICTED: nucleoside ( 186) 275 62.4 1.5e-09 XP_016861002 (OMIM: 608294) PREDICTED: nucleoside ( 190) 275 62.4 1.5e-09 NP_005784 (OMIM: 608294) nucleoside diphosphate ki ( 194) 275 62.4 1.6e-09 NP_932076 (OMIM: 613465) nucleoside diphosphate ki ( 340) 274 62.5 2.7e-09 XP_016856588 (OMIM: 613465) PREDICTED: nucleoside ( 367) 274 62.5 2.8e-09 NP_037462 (OMIM: 613465) nucleoside diphosphate ki ( 376) 274 62.5 2.9e-09 NP_001295363 (OMIM: 608294) nucleoside diphosphate ( 141) 234 54.5 2.7e-07 NP_005000 (OMIM: 601818) nucleoside diphosphate ki ( 187) 190 46.3 0.00011 XP_016861007 (OMIM: 608294) PREDICTED: nucleoside ( 111) 184 45.0 0.00016 XP_016861006 (OMIM: 608294) PREDICTED: nucleoside ( 114) 182 44.6 0.00021 XP_016856589 (OMIM: 613465) PREDICTED: nucleoside ( 252) 185 45.5 0.00026 XP_005245163 (OMIM: 613465) PREDICTED: nucleoside ( 252) 185 45.5 0.00026 XP_016861001 (OMIM: 608294) PREDICTED: nucleoside ( 264) 182 44.9 0.00039 NP_003320 (OMIM: 187700) thioredoxin isoform 1 [Ho ( 105) 172 42.7 0.00075 NP_001273368 (OMIM: 601818) nucleoside diphosphate ( 117) 170 42.3 0.0011 NP_001273365 (OMIM: 601818) nucleoside diphosphate ( 117) 170 42.3 0.0011 NP_001273367 (OMIM: 601818) nucleoside diphosphate ( 117) 170 42.3 0.0011 NP_001273369 (OMIM: 601818) nucleoside diphosphate ( 117) 170 42.3 0.0011 >>NP_057700 (OMIM: 607421,610852) thioredoxin domain-con (588 aa) initn: 3815 init1: 3815 opt: 3815 Z-score: 3911.3 bits: 733.7 E(85289): 4e-211 Smith-Waterman score: 3815; 99.7% identity (99.7% similar) in 588 aa overlap (1-588:1-588) 10 20 30 40 50 60 pF1KE3 MASKKREVQLQTVINNQSLWDEMLQNKGLTVIDVYQAWCGPCRAMQPLFRKLKNELNEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MASKKREVQLQTVINNQSLWDEMLQNKGLTVIDVYQAWCGPCRAMQPLFRKLKNELNEDE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 ILHFAVAEADNIVTLQPFRDKCEPVFLFSVNGKIIEKIQGANAPLVNKKVINLIDEERKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 ILHFAVAEADNIVTLQPFRDKCEPVFLFSVNGKIIEKIQGANAPLVNKKVINLIDEERKI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 AAGEMARPQYPEIPLVDSDSEVSEESPCESVQELYSIAIIKPDAVISKKVLEIKRKITKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 AAGEMARPQYPEIPLVDSDSEVSEESPCESVQELYSIAIIKPDAVISKKVLEIKRKITKA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 GFIIEAEHKTVLTEEQVVNFYSRIADQRDFEEFVSFMTSGLSYILVVSQGSKHNPPSEET ::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::: NP_057 GFIIEAEHKTVLTEEQVVNFYSRIADQCDFEEFVSFMTSGLSYILVVSQGSKHNPPSEET 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 EPQTDTEPNERSEDQPEVEAQVTPGMMKNKQDSLQEYLERQHLAQLCDIEEDAANVAKFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 EPQTDTEPNERSEDQPEVEAQVTPGMMKNKQDSLQEYLERQHLAQLCDIEEDAANVAKFM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 DAFFPDFKKMKSMKLEKTLALLRPNLFHERKDDVLRIIKDEDFKILEQRQVVLSEKEAQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 DAFFPDFKKMKSMKLEKTLALLRPNLFHERKDDVLRIIKDEDFKILEQRQVVLSEKEAQA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 LCKEYENEDYFNKLIENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 LCKEYENEDYFNKLIENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 FAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQREQILKIVKEAGFDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 FAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQREQILKIVKEAGFDL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 TQVKKMFLTPEQTEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMGPTD :::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::: NP_057 TQVKKMFLTPEQIEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMGPTD 490 500 510 520 530 540 550 560 570 580 pF1KE3 PEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN :::::::::::::::::::::::::::::::::::::::::::::::: NP_057 PEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN 550 560 570 580 >>XP_005272156 (OMIM: 603575) PREDICTED: nucleoside diph (148 aa) initn: 525 init1: 252 opt: 311 Z-score: 330.5 bits: 69.1 E(85289): 1.1e-11 Smith-Waterman score: 311; 38.4% identity (68.8% similar) in 138 aa overlap (450-587:12-146) 420 430 440 450 460 470 pF1KE3 QFAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQREQILKIVKEAGFD ...::..::: . ...:.: :. ..:: XP_005 MEISMPPPQIYVEKTLAIIKPDIV-DKEEEIQDIILRSGFT 10 20 30 40 480 490 500 510 520 530 pF1KE3 LTQVKKMFLTPEQTEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMGPT ..: .:. :.::: ..: . :: :. .: ..: :: ..:::.. .:.. : .:.::. XP_005 IVQRRKLRLSPEQCSNFYVEKYGKMFFPNLTAYMSSGPLVAMILARHKAISYWLELLGPN 50 60 70 80 90 100 540 550 560 570 580 pF1KE3 DPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN . :: :::.:: .: . :.: .:: :: . : : : : ::: XP_005 NSLVAKETHPDSLRAIYGTDDLRNALHG-SNDFAAAEREIR-FMFPEEKL 110 120 130 140 >>XP_006714779 (OMIM: 603575) PREDICTED: nucleoside diph (149 aa) initn: 525 init1: 252 opt: 307 Z-score: 326.4 bits: 68.4 E(85289): 1.9e-11 Smith-Waterman score: 307; 37.7% identity (68.8% similar) in 138 aa overlap (450-587:12-146) 420 430 440 450 460 470 pF1KE3 QFAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQREQILKIVKEAGFD ...::..::: . ...:.: :. ..:: XP_006 MEISMPPPQIYVEKTLAIIKPDIV-DKEEEIQDIILRSGFT 10 20 30 40 480 490 500 510 520 530 pF1KE3 LTQVKKMFLTPEQTEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMGPT ..: .:. :.::: ..: . :: :. .: ..: :: ..:::.. .:.. : .:.::. XP_006 IVQRRKLRLSPEQCSNFYVEKYGKMFFPNLTAYMSSGPLVAMILARHKAISYWLELLGPN 50 60 70 80 90 100 540 550 560 570 580 pF1KE3 DPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN . :: :::.:: .: . :.: .:: :: . : : : : ::. XP_006 NSLVAKETHPDSLRAIYGTDDLRNALHG-SNDFAAAEREIR-FMFPEDLAS 110 120 130 140 >>NP_003542 (OMIM: 603575) nucleoside diphosphate kinase (212 aa) initn: 525 init1: 252 opt: 305 Z-score: 322.4 bits: 68.2 E(85289): 3.2e-11 Smith-Waterman score: 305; 38.0% identity (68.6% similar) in 137 aa overlap (450-586:12-145) 420 430 440 450 460 470 pF1KE3 QFAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQREQILKIVKEAGFD ...::..::: . ...:.: :. ..:: NP_003 MEISMPPPQIYVEKTLAIIKPDIV-DKEEEIQDIILRSGFT 10 20 30 40 480 490 500 510 520 530 pF1KE3 LTQVKKMFLTPEQTEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMGPT ..: .:. :.::: ..: . :: :. .: ..: :: ..:::.. .:.. : .:.::. NP_003 IVQRRKLRLSPEQCSNFYVEKYGKMFFPNLTAYMSSGPLVAMILARHKAISYWLELLGPN 50 60 70 80 90 100 540 550 560 570 580 pF1KE3 DPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN . :: :::.:: .: . :.: .:: :: . : : : : :: NP_003 NSLVAKETHPDSLRAIYGTDDLRNALHG-SNDFAAAEREIR-FMFPEVIVEPIPIGQAAK 110 120 130 140 150 NP_003 DYLNLHIMPTLLEGLTELCKQKPADPLIWLADWLLKNNPNKPKLCHHPIVEEPY 160 170 180 190 200 210 >>XP_016865434 (OMIM: 603575) PREDICTED: nucleoside diph (278 aa) initn: 529 init1: 252 opt: 305 Z-score: 320.8 bits: 68.3 E(85289): 3.9e-11 Smith-Waterman score: 305; 38.0% identity (68.6% similar) in 137 aa overlap (450-586:12-145) 420 430 440 450 460 470 pF1KE3 QFAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQREQILKIVKEAGFD ...::..::: . ...:.: :. ..:: XP_016 MEISMPPPQIYVEKTLAIIKPDIV-DKEEEIQDIILRSGFT 10 20 30 40 480 490 500 510 520 530 pF1KE3 LTQVKKMFLTPEQTEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMGPT ..: .:. :.::: ..: . :: :. .: ..: :: ..:::.. .:.. : .:.::. XP_016 IVQRRKLRLSPEQCSNFYVEKYGKMFFPNLTAYMSSGPLVAMILARHKAISYWLELLGPN 50 60 70 80 90 100 540 550 560 570 580 pF1KE3 DPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN . :: :::.:: .: . :.: .:: :: . : : : : :: XP_016 NSLVAKETHPDSLRAIYGTDDLRNALHG-SNDFAAAEREIR-FMFPEVIVEPIPIGQAAK 110 120 130 140 150 XP_016 DYLNLHIMPTLLEGLTELCKQKPADPLFWYMCCRREHWTLRSILLVCMSGIRMSLPHCAD 160 170 180 190 200 210 >>NP_001295355 (OMIM: 608294) nucleoside diphosphate kin (186 aa) initn: 418 init1: 211 opt: 275 Z-score: 292.4 bits: 62.4 E(85289): 1.5e-09 Smith-Waterman score: 275; 32.1% identity (67.9% similar) in 140 aa overlap (450-587:11-150) 420 430 440 450 460 470 pF1KE3 QFAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQR--EQILKIVKEAG :: ::.:::: :... : . . . NP_001 MASILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNK 10 20 30 40 480 490 500 510 520 530 pF1KE3 FDLTQVKKMFLTPEQTEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMG : ........ :. ...: . :. ::. :.:... :: ..::.. .:. :: ::: NP_001 FLIVRMRELLWRKEDCQRFYREHEGRFFYQRLVEFMASGPIRAYILAHKDAIQLWRTLMG 50 60 70 80 90 100 540 550 560 570 580 pF1KE3 PTDPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN :: .:. ..:::::..::.. .: .::.... :.. . .: : : NP_001 PTRVFRARHVAPDSIRGSFGLTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQ 110 120 130 140 150 160 NP_001 LRCGPVCYSPEGGVHYVAGTGGLGPA 170 180 >>NP_001295357 (OMIM: 608294) nucleoside diphosphate kin (186 aa) initn: 418 init1: 211 opt: 275 Z-score: 292.4 bits: 62.4 E(85289): 1.5e-09 Smith-Waterman score: 275; 32.1% identity (67.9% similar) in 140 aa overlap (450-587:11-150) 420 430 440 450 460 470 pF1KE3 QFAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQR--EQILKIVKEAG :: ::.:::: :... : . . . NP_001 MASILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNK 10 20 30 40 480 490 500 510 520 530 pF1KE3 FDLTQVKKMFLTPEQTEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMG : ........ :. ...: . :. ::. :.:... :: ..::.. .:. :: ::: NP_001 FLIVRMRELLWRKEDCQRFYREHEGRFFYQRLVEFMASGPIRAYILAHKDAIQLWRTLMG 50 60 70 80 90 100 540 550 560 570 580 pF1KE3 PTDPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN :: .:. ..:::::..::.. .: .::.... :.. . .: : : NP_001 PTRVFRARHVAPDSIRGSFGLTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQ 110 120 130 140 150 160 NP_001 LRCGPVCYSPEGGVHYVAGTGGLGPA 170 180 >>NP_001295356 (OMIM: 608294) nucleoside diphosphate kin (186 aa) initn: 418 init1: 211 opt: 275 Z-score: 292.4 bits: 62.4 E(85289): 1.5e-09 Smith-Waterman score: 275; 32.1% identity (67.9% similar) in 140 aa overlap (450-587:11-150) 420 430 440 450 460 470 pF1KE3 QFAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQR--EQILKIVKEAG :: ::.:::: :... : . . . NP_001 MASILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNK 10 20 30 40 480 490 500 510 520 530 pF1KE3 FDLTQVKKMFLTPEQTEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMG : ........ :. ...: . :. ::. :.:... :: ..::.. .:. :: ::: NP_001 FLIVRMRELLWRKEDCQRFYREHEGRFFYQRLVEFMASGPIRAYILAHKDAIQLWRTLMG 50 60 70 80 90 100 540 550 560 570 580 pF1KE3 PTDPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN :: .:. ..:::::..::.. .: .::.... :.. . .: : : NP_001 PTRVFRARHVAPDSIRGSFGLTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQ 110 120 130 140 150 160 NP_001 LRCGPVCYSPEGGVHYVAGTGGLGPA 170 180 >>XP_016861003 (OMIM: 608294) PREDICTED: nucleoside diph (186 aa) initn: 418 init1: 211 opt: 275 Z-score: 292.4 bits: 62.4 E(85289): 1.5e-09 Smith-Waterman score: 275; 32.1% identity (67.9% similar) in 140 aa overlap (450-587:11-150) 420 430 440 450 460 470 pF1KE3 QFAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQR--EQILKIVKEAG :: ::.:::: :... : . . . XP_016 MASILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNK 10 20 30 40 480 490 500 510 520 530 pF1KE3 FDLTQVKKMFLTPEQTEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMG : ........ :. ...: . :. ::. :.:... :: ..::.. .:. :: ::: XP_016 FLIVRMRELLWRKEDCQRFYREHEGRFFYQRLVEFMASGPIRAYILAHKDAIQLWRTLMG 50 60 70 80 90 100 540 550 560 570 580 pF1KE3 PTDPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN :: .:. ..:::::..::.. .: .::.... :.. . .: : : XP_016 PTRVFRARHVAPDSIRGSFGLTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQ 110 120 130 140 150 160 XP_016 LRCGPVCYSPEGGVHYVAGTGGLGPA 170 180 >>XP_016861002 (OMIM: 608294) PREDICTED: nucleoside diph (190 aa) initn: 418 init1: 211 opt: 275 Z-score: 292.2 bits: 62.4 E(85289): 1.5e-09 Smith-Waterman score: 275; 32.1% identity (67.9% similar) in 140 aa overlap (450-587:15-154) 420 430 440 450 460 470 pF1KE3 QFAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQR--EQILKIVKEAG :: ::.:::: :... : . . . XP_016 MRSEMASILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNK 10 20 30 40 480 490 500 510 520 530 pF1KE3 FDLTQVKKMFLTPEQTEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMG : ........ :. ...: . :. ::. :.:... :: ..::.. .:. :: ::: XP_016 FLIVRMRELLWRKEDCQRFYREHEGRFFYQRLVEFMASGPIRAYILAHKDAIQLWRTLMG 50 60 70 80 90 100 540 550 560 570 580 pF1KE3 PTDPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN :: .:. ..:::::..::.. .: .::.... :.. . .: : : XP_016 PTRVFRARHVAPDSIRGSFGLTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQ 110 120 130 140 150 160 XP_016 LRCGPVCYSPEGGVHYVAGTGGLGPA 170 180 190 588 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 18:48:58 2016 done: Mon Nov 7 18:48:59 2016 Total Scan time: 8.140 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]