FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4103, 472 aa 1>>>pF1KE4103 472 - 472 aa - 472 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6368+/-0.00049; mu= 16.0618+/- 0.030 mean_var=77.1817+/-16.079, 0's: 0 Z-trim(109.4): 196 B-trim: 1279 in 2/52 Lambda= 0.145988 statistics sampled from 17320 (17534) to 17320 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.568), E-opt: 0.2 (0.206), width: 16 Scan time: 7.530 The best scores are: opt bits E(85289) NP_001287664 (OMIM: 614532) ras-GEF domain-contain ( 472) 3162 676.2 5.4e-194 NP_689758 (OMIM: 614532) ras-GEF domain-containing ( 473) 3150 673.6 3.1e-193 XP_016863302 (OMIM: 614532) PREDICTED: ras-GEF dom ( 473) 3150 673.6 3.1e-193 NP_001287665 (OMIM: 614532) ras-GEF domain-contain ( 431) 2474 531.2 2.1e-150 XP_016863301 (OMIM: 614532) PREDICTED: ras-GEF dom ( 432) 2462 528.7 1.2e-149 NP_660356 (OMIM: 614531) ras-GEF domain-containing ( 481) 1905 411.4 2.7e-114 NP_001269791 (OMIM: 614531) ras-GEF domain-contain ( 489) 1905 411.4 2.8e-114 XP_005271866 (OMIM: 614531) PREDICTED: ras-GEF dom ( 401) 1671 362.1 1.6e-99 XP_011537802 (OMIM: 614531) PREDICTED: ras-GEF dom ( 401) 1671 362.1 1.6e-99 NP_055062 (OMIM: 609530) rap guanine nucleotide ex (1499) 345 83.1 5.6e-15 XP_016864348 (OMIM: 609530) PREDICTED: rap guanine (1524) 345 83.1 5.7e-15 XP_011530729 (OMIM: 609530) PREDICTED: rap guanine (1540) 345 83.2 5.8e-15 XP_016864347 (OMIM: 609530) PREDICTED: rap guanine (1544) 345 83.2 5.8e-15 XP_016864346 (OMIM: 609530) PREDICTED: rap guanine (1544) 345 83.2 5.8e-15 XP_011530728 (OMIM: 609530) PREDICTED: rap guanine (1585) 345 83.2 5.9e-15 XP_006714485 (OMIM: 609530) PREDICTED: rap guanine (1585) 345 83.2 5.9e-15 XP_011530727 (OMIM: 609530) PREDICTED: rap guanine (1589) 345 83.2 5.9e-15 XP_005263418 (OMIM: 609530) PREDICTED: rap guanine (1654) 345 83.2 6.1e-15 XP_005263417 (OMIM: 609530) PREDICTED: rap guanine (1660) 345 83.2 6.1e-15 XP_006714484 (OMIM: 609530) PREDICTED: rap guanine (1685) 345 83.2 6.2e-15 XP_006714483 (OMIM: 609530) PREDICTED: rap guanine (1695) 345 83.2 6.2e-15 XP_005263415 (OMIM: 609530) PREDICTED: rap guanine (1701) 345 83.2 6.3e-15 XP_016864345 (OMIM: 609530) PREDICTED: rap guanine (1652) 341 82.3 1.1e-14 XP_005263416 (OMIM: 609530) PREDICTED: rap guanine (1693) 341 82.3 1.1e-14 NP_001157861 (OMIM: 610499) rap guanine nucleotide (1391) 312 76.2 6.6e-13 NP_001157860 (OMIM: 610499) rap guanine nucleotide (1504) 312 76.2 7e-13 NP_001157859 (OMIM: 610499) rap guanine nucleotide (1509) 312 76.2 7e-13 NP_057424 (OMIM: 610499) rap guanine nucleotide ex (1601) 312 76.2 7.4e-13 NP_001157858 (OMIM: 610499) rap guanine nucleotide (1609) 312 76.2 7.4e-13 XP_016865171 (OMIM: 606614) PREDICTED: ras-specifi (1142) 303 74.2 2.1e-12 NP_008840 (OMIM: 606614) ras-specific guanine nucl (1237) 303 74.3 2.2e-12 NP_722522 (OMIM: 606600) ras-specific guanine nucl ( 489) 295 72.3 3.3e-12 NP_001139120 (OMIM: 606600) ras-specific guanine n (1257) 295 72.6 7.2e-12 XP_016877945 (OMIM: 606600) PREDICTED: ras-specifi (1260) 295 72.6 7.2e-12 XP_016877944 (OMIM: 606600) PREDICTED: ras-specifi (1270) 295 72.6 7.3e-12 NP_002882 (OMIM: 606600) ras-specific guanine nucl (1273) 295 72.6 7.3e-12 NP_001269830 (OMIM: 606058) rap guanine nucleotide ( 791) 278 68.9 5.9e-11 NP_001269829 (OMIM: 606058) rap guanine nucleotide ( 840) 278 68.9 6.2e-11 XP_006712268 (OMIM: 606058) PREDICTED: rap guanine ( 840) 278 68.9 6.2e-11 XP_016858686 (OMIM: 606058) PREDICTED: rap guanine ( 849) 278 68.9 6.3e-11 NP_001269828 (OMIM: 606058) rap guanine nucleotide ( 858) 278 68.9 6.3e-11 NP_001093867 (OMIM: 606058) rap guanine nucleotide ( 867) 278 68.9 6.4e-11 XP_011508807 (OMIM: 606058) PREDICTED: rap guanine ( 881) 278 68.9 6.4e-11 XP_016858685 (OMIM: 606058) PREDICTED: rap guanine ( 960) 278 68.9 6.9e-11 XP_005246303 (OMIM: 606058) PREDICTED: rap guanine ( 993) 278 68.9 7.1e-11 NP_008954 (OMIM: 606058) rap guanine nucleotide ex (1011) 278 68.9 7.2e-11 XP_005268628 (OMIM: 606057) PREDICTED: rap guanine ( 495) 266 66.2 2.3e-10 NP_001293015 (OMIM: 603962) RAS guanyl-releasing p ( 597) 266 66.3 2.7e-10 XP_011519453 (OMIM: 603962) PREDICTED: RAS guanyl- ( 632) 266 66.3 2.8e-10 XP_005254171 (OMIM: 603962) PREDICTED: RAS guanyl- ( 746) 266 66.3 3.2e-10 >>NP_001287664 (OMIM: 614532) ras-GEF domain-containing (472 aa) initn: 3162 init1: 3162 opt: 3162 Z-score: 3603.7 bits: 676.2 E(85289): 5.4e-194 Smith-Waterman score: 3162; 100.0% identity (100.0% similar) in 472 aa overlap (1-472:1-472) 10 20 30 40 50 60 pF1KE4 MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 TYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTET 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 FPYDFRDERMMRNLKDLAHRIASGEETYRKNVQQMMQCLIRKLAALSQYEEVLAKISSTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FPYDFRDERMMRNLKDLAHRIASGEETYRKNVQQMMQCLIRKLAALSQYEEVLAKISSTS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 TDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 DKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 FNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 AHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECP 370 380 390 400 410 420 430 440 450 460 470 pF1KE4 FERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV 430 440 450 460 470 >>NP_689758 (OMIM: 614532) ras-GEF domain-containing fam (473 aa) initn: 2163 init1: 2163 opt: 3150 Z-score: 3590.1 bits: 673.6 E(85289): 3.1e-193 Smith-Waterman score: 3150; 99.8% identity (99.8% similar) in 473 aa overlap (1-472:1-473) 10 20 30 40 50 60 pF1KE4 MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 TYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 TYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTET 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 FPYDFRDERMMRNLKDLAHRIASGEE-TYRKNVQQMMQCLIRKLAALSQYEEVLAKISST :::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::: NP_689 FPYDFRDERMMRNLKDLAHRIASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISST 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 STDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 STDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLD 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE4 NDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 NDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIG 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE4 NFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 NFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSL 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE4 TAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 TAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVEC 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE4 PFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 PFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV 430 440 450 460 470 >>XP_016863302 (OMIM: 614532) PREDICTED: ras-GEF domain- (473 aa) initn: 2163 init1: 2163 opt: 3150 Z-score: 3590.1 bits: 673.6 E(85289): 3.1e-193 Smith-Waterman score: 3150; 99.8% identity (99.8% similar) in 473 aa overlap (1-472:1-473) 10 20 30 40 50 60 pF1KE4 MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 TYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTET 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 FPYDFRDERMMRNLKDLAHRIASGEE-TYRKNVQQMMQCLIRKLAALSQYEEVLAKISST :::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::: XP_016 FPYDFRDERMMRNLKDLAHRIASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISST 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 STDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLD 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE4 NDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIG 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE4 NFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSL 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE4 TAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVEC 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE4 PFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV 430 440 450 460 470 >>NP_001287665 (OMIM: 614532) ras-GEF domain-containing (431 aa) initn: 2862 init1: 2463 opt: 2474 Z-score: 2821.2 bits: 531.2 E(85289): 2.1e-150 Smith-Waterman score: 2784; 91.3% identity (91.3% similar) in 472 aa overlap (1-472:1-431) 10 20 30 40 50 60 pF1KE4 MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDR ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPD- 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 TYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTET :::::::::::::::::::: NP_001 ----------------------------------------NQMRKIAPKILQLLTEWTET 60 70 130 140 150 160 170 180 pF1KE4 FPYDFRDERMMRNLKDLAHRIASGEETYRKNVQQMMQCLIRKLAALSQYEEVLAKISSTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FPYDFRDERMMRNLKDLAHRIASGEETYRKNVQQMMQCLIRKLAALSQYEEVLAKISSTS 80 90 100 110 120 130 190 200 210 220 230 240 pF1KE4 TDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDN 140 150 160 170 180 190 250 260 270 280 290 300 pF1KE4 DKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGN 200 210 220 230 240 250 310 320 330 340 350 360 pF1KE4 FNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLT 260 270 280 290 300 310 370 380 390 400 410 420 pF1KE4 AHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECP 320 330 340 350 360 370 430 440 450 460 470 pF1KE4 FERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV 380 390 400 410 420 430 >>XP_016863301 (OMIM: 614532) PREDICTED: ras-GEF domain- (432 aa) initn: 2562 init1: 2163 opt: 2462 Z-score: 2807.5 bits: 528.7 E(85289): 1.2e-149 Smith-Waterman score: 2772; 91.1% identity (91.1% similar) in 473 aa overlap (1-472:1-432) 10 20 30 40 50 60 pF1KE4 MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDR ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPD- 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 TYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTET :::::::::::::::::::: XP_016 ----------------------------------------NQMRKIAPKILQLLTEWTET 60 70 130 140 150 160 170 pF1KE4 FPYDFRDERMMRNLKDLAHRIASGEE-TYRKNVQQMMQCLIRKLAALSQYEEVLAKISST :::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::: XP_016 FPYDFRDERMMRNLKDLAHRIASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISST 80 90 100 110 120 130 180 190 200 210 220 230 pF1KE4 STDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLD 140 150 160 170 180 190 240 250 260 270 280 290 pF1KE4 NDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIG 200 210 220 230 240 250 300 310 320 330 340 350 pF1KE4 NFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSL 260 270 280 290 300 310 360 370 380 390 400 410 pF1KE4 TAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVEC 320 330 340 350 360 370 420 430 440 450 460 470 pF1KE4 PFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV 380 390 400 410 420 430 >>NP_660356 (OMIM: 614531) ras-GEF domain-containing fam (481 aa) initn: 1863 init1: 1160 opt: 1905 Z-score: 2172.8 bits: 411.4 E(85289): 2.7e-114 Smith-Waterman score: 1906; 58.6% identity (82.7% similar) in 481 aa overlap (1-471:1-480) 10 20 30 40 50 pF1KE4 MPQTPP-FSAMFDSSGYNR---NLYQSAEDSCGG---LYYHDNNLLSGSLEALIQHLVPN :::: ::... : .. .. . . . :: : ..:..:.:::::::..::::. NP_660 MPQTSVVFSSILGPSCSGQVQPGMGERGGGAGGGSGDLIFQDGHLISGSLEALMEHLVPT 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 VDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQL ::::::::::::::::::.:: :..:.:.: ..:::... . .: ...... ::.:: NP_660 VDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICVEQKQQLEAGPEKAKLKSFSAKIVQL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE4 LTEWTETFPYDFRDERMMRNLKDLAHRIASGEE---TYRKNVQQMMQCLIRKLAALSQYE : ::::.:::::.::. : .:: ..::... .: : .: . :: : :. .::: :: . NP_660 LKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEENGTVKKAIAQMTQSLLLSLAARSQLQ 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 EVLAKISSTSTDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQ :. :. ..:. .::::: . :.::. :: :: .::::::::::.:.. : ::...: NP_660 ELREKLRPPAVDKGPILKTKPPAAQKDILGVCCDPLVLAQQLTHIELDRVSSIYPEDLMQ 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE4 AFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFID . : ::: . : .. :: .:::: .::: ::.:::::.: ::::::.::.:.::: NP_660 IVSHMDSLDNHR-CRGDLTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFID 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 VARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTA :::::::::::::.::::::::.:::.::::::.::::::::.:::.::::::: ::::: NP_660 VARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDPSSNFCNYRTA 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 LRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSE :.::.::: :.::::::::: :.:..::::::.. .:.:::::.::.::::...:. : NP_660 LQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQIHE 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE4 FMTWKQVECPFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLG :::: :::::::.:.:: .::::.:..::.::..::.::::::::.::: ::.::..::. NP_660 FMTWTQVECPFEKDKKIQSYLLTAPIYSEEALFVASFESEGPENHMEKDSWKTLRTTLLN 420 430 440 450 460 470 pF1KE4 RV : NP_660 RA 480 >>NP_001269791 (OMIM: 614531) ras-GEF domain-containing (489 aa) initn: 1863 init1: 1160 opt: 1905 Z-score: 2172.7 bits: 411.4 E(85289): 2.8e-114 Smith-Waterman score: 1906; 58.6% identity (82.7% similar) in 481 aa overlap (1-471:9-488) 10 20 30 40 pF1KE4 MPQTPP-FSAMFDSSGYNR---NLYQSAEDSCGG---LYYHDNNLLSGSLEA :::: ::... : .. .. . . . :: : ..:..:.:::::: NP_001 MFLEPQETMPQTSVVFSSILGPSCSGQVQPGMGERGGGAGGGSGDLIFQDGHLISGSLEA 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE4 LIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRK :..::::.::::::::::::::::::.:: :..:.:.: ..:::... . .: .... NP_001 LMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICVEQKQQLEAGPEKAKLKS 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE4 IAPKILQLLTEWTETFPYDFRDERMMRNLKDLAHRIASGEE---TYRKNVQQMMQCLIRK .. ::.::: ::::.:::::.::. : .:: ..::... .: : .: . :: : :. . NP_001 FSAKIVQLLKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEENGTVKKAIAQMTQSLLLS 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE4 LAALSQYEEVLAKISSTSTDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNY ::: :: .:. :. ..:. .::::: . :.::. :: :: .::::::::::.:.. NP_001 LAARSQLQELREKLRPPAVDKGPILKTKPPAAQKDILGVCCDPLVLAQQLTHIELDRVSS 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE4 IGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRA : ::...: . : ::: . : .. :: .:::: .::: ::.:::::.: ::::::. NP_001 IYPEDLMQIVSHMDSLDNHR-CRGDLTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRT 250 260 270 280 290 290 300 310 320 330 340 pF1KE4 RMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSS ::.:.::::::::::::::::.::::::::.:::.::::::.::::::::.:::.::::: NP_001 RMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDPSS 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE4 NFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFW :: ::::::.::.::: :.::::::::: :.:..::::::.. .:.:::::.::.::: NP_001 NFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFW 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE4 ELAKQVSEFMTWKQVECPFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWK :...:. ::::: :::::::.:.:: .::::.:..::.::..::.::::::::.::: :: NP_001 EISRQIHEFMTWTQVECPFEKDKKIQSYLLTAPIYSEEALFVASFESEGPENHMEKDSWK 420 430 440 450 460 470 470 pF1KE4 SLRSSLLGRV .::..::.: NP_001 TLRTTLLNRA 480 >>XP_005271866 (OMIM: 614531) PREDICTED: ras-GEF domain- (401 aa) initn: 1621 init1: 1160 opt: 1671 Z-score: 1907.6 bits: 362.1 E(85289): 1.6e-99 Smith-Waterman score: 1671; 59.9% identity (84.0% similar) in 401 aa overlap (74-471:1-400) 50 60 70 80 90 100 pF1KE4 EALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQM : :..:.:.: ..:::... . .: .. XP_005 MPPHDLLARVGQICVEQKQQLEAGPEKAKL 10 20 30 110 120 130 140 150 160 pF1KE4 RKIAPKILQLLTEWTETFPYDFRDERMMRNLKDLAHRIASGEE---TYRKNVQQMMQCLI .... ::.::: ::::.:::::.::. : .:: ..::... .: : .: . :: : :. XP_005 KSFSAKIVQLLKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEENGTVKKAIAQMTQSLL 40 50 60 70 80 90 170 180 190 200 210 220 pF1KE4 RKLAALSQYEEVLAKISSTSTDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERL .::: :: .:. :. ..:. .::::: . :.::. :: :: .::::::::::.:. XP_005 LSLAARSQLQELREKLRPPAVDKGPILKTKPPAAQKDILGVCCDPLVLAQQLTHIELDRV 100 110 120 130 140 150 230 240 250 260 270 280 pF1KE4 NYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKH . : ::...: . : ::: . : .. :: .:::: .::: ::.:::::.: ::::: XP_005 SSIYPEDLMQIVSHMDSLDNHR-CRGDLTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKH 160 170 180 190 200 290 300 310 320 330 340 pF1KE4 RARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDP :.::.:.::::::::::::::::.::::::::.:::.::::::.::::::::.:::.::: XP_005 RTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDP 210 220 230 240 250 260 350 360 370 380 390 400 pF1KE4 SSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEK :::: ::::::.::.::: :.::::::::: :.:..::::::.. .:.:::::.::.: XP_005 SSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKK 270 280 290 300 310 320 410 420 430 440 450 460 pF1KE4 FWELAKQVSEFMTWKQVECPFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDR :::...:. ::::: :::::::.:.:: .::::.:..::.::..::.::::::::.::: XP_005 FWEISRQIHEFMTWTQVECPFEKDKKIQSYLLTAPIYSEEALFVASFESEGPENHMEKDS 330 340 350 360 370 380 470 pF1KE4 WKSLRSSLLGRV ::.::..::.: XP_005 WKTLRTTLLNRA 390 400 >>XP_011537802 (OMIM: 614531) PREDICTED: ras-GEF domain- (401 aa) initn: 1621 init1: 1160 opt: 1671 Z-score: 1907.6 bits: 362.1 E(85289): 1.6e-99 Smith-Waterman score: 1671; 59.9% identity (84.0% similar) in 401 aa overlap (74-471:1-400) 50 60 70 80 90 100 pF1KE4 EALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQM : :..:.:.: ..:::... . .: .. XP_011 MPPHDLLARVGQICVEQKQQLEAGPEKAKL 10 20 30 110 120 130 140 150 160 pF1KE4 RKIAPKILQLLTEWTETFPYDFRDERMMRNLKDLAHRIASGEE---TYRKNVQQMMQCLI .... ::.::: ::::.:::::.::. : .:: ..::... .: : .: . :: : :. XP_011 KSFSAKIVQLLKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEENGTVKKAIAQMTQSLL 40 50 60 70 80 90 170 180 190 200 210 220 pF1KE4 RKLAALSQYEEVLAKISSTSTDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERL .::: :: .:. :. ..:. .::::: . :.::. :: :: .::::::::::.:. XP_011 LSLAARSQLQELREKLRPPAVDKGPILKTKPPAAQKDILGVCCDPLVLAQQLTHIELDRV 100 110 120 130 140 150 230 240 250 260 270 280 pF1KE4 NYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKH . : ::...: . : ::: . : .. :: .:::: .::: ::.:::::.: ::::: XP_011 SSIYPEDLMQIVSHMDSLDNHR-CRGDLTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKH 160 170 180 190 200 290 300 310 320 330 340 pF1KE4 RARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDP :.::.:.::::::::::::::::.::::::::.:::.::::::.::::::::.:::.::: XP_011 RTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDP 210 220 230 240 250 260 350 360 370 380 390 400 pF1KE4 SSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEK :::: ::::::.::.::: :.::::::::: :.:..::::::.. .:.:::::.::.: XP_011 SSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKK 270 280 290 300 310 320 410 420 430 440 450 460 pF1KE4 FWELAKQVSEFMTWKQVECPFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDR :::...:. ::::: :::::::.:.:: .::::.:..::.::..::.::::::::.::: XP_011 FWEISRQIHEFMTWTQVECPFEKDKKIQSYLLTAPIYSEEALFVASFESEGPENHMEKDS 330 340 350 360 370 380 470 pF1KE4 WKSLRSSLLGRV ::.::..::.: XP_011 WKTLRTTLLNRA 390 400 >>NP_055062 (OMIM: 609530) rap guanine nucleotide exchan (1499 aa) initn: 352 init1: 214 opt: 345 Z-score: 389.8 bits: 83.1 E(85289): 5.6e-15 Smith-Waterman score: 352; 30.2% identity (60.9% similar) in 258 aa overlap (208-458:721-958) 180 190 200 210 220 230 pF1KE4 STSTDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDP .: ::. ..: . : : :... . . NP_055 METETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFK--- 700 710 720 730 740 240 250 260 270 280 290 pF1KE4 LDNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFN : . :: ::. . : .:. .. ::.:: ... .: ..:..:: .: .: . NP_055 LRSKTSCA-------NLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRE 750 760 770 780 790 800 300 310 320 330 340 350 pF1KE4 IGNFNSLMAIISGMNMSPVSRLKKTWAKV--KTAK-FDILEHQMDPSSNFYNYRTALRGA ::::..:::::.:..::.::. :: :. : : :. :. .::: :. .::..: . NP_055 CKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNS- 810 820 830 840 850 360 370 380 390 400 410 pF1KE4 AQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTW .. . .::.: .. ::. ::.:: ... .: :::::. .::.. . NP_055 --------QNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRM 860 870 880 890 900 910 420 430 440 450 460 470 pF1KE4 KQVEC-P---FERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLG .:. : :. .: . : .. : .: : .. : ...... NP_055 ASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSSFLNAKKLYED 920 930 940 950 960 970 pF1KE4 RV NP_055 AQMARKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKNPGDKKPVKSETSPVAPRAGS 980 990 1000 1010 1020 1030 472 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 18:13:23 2016 done: Mon Nov 7 18:13:25 2016 Total Scan time: 7.530 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]