FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1120, 364 aa 1>>>pF1KE1120 364 - 364 aa - 364 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.1446+/-0.000385; mu= 23.7456+/- 0.025 mean_var=101.8230+/-26.632, 0's: 0 Z-trim(112.9): 536 B-trim: 2230 in 2/50 Lambda= 0.127102 statistics sampled from 21239 (22005) to 21239 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.617), E-opt: 0.2 (0.258), width: 16 Scan time: 7.520 The best scores are: opt bits E(85289) NP_000504 (OMIM: 300821,303700,303800) medium-wave ( 364) 2496 468.7 9.4e-132 NP_064445 (OMIM: 300822,303700,303900) long-wave-s ( 364) 2427 456.0 6.1e-128 NP_001699 (OMIM: 190900,613522) short-wave-sensiti ( 348) 1033 200.4 5.3e-51 NP_000530 (OMIM: 136880,180380,610445,613731) rhod ( 348) 1002 194.7 2.7e-49 NP_055137 (OMIM: 606695) opsin-3 [Homo sapiens] ( 402) 512 104.9 3.3e-22 NP_006574 (OMIM: 605224) visual pigment-like recep ( 337) 507 103.9 5.6e-22 NP_859528 (OMIM: 609042) opsin-5 [Homo sapiens] ( 354) 446 92.7 1.3e-18 XP_016865905 (OMIM: 609042) PREDICTED: opsin-5 iso ( 408) 446 92.8 1.4e-18 XP_016865900 (OMIM: 609042) PREDICTED: opsin-5 iso ( 298) 409 85.8 1.3e-16 NP_150598 (OMIM: 606665) melanopsin isoform 1 [Hom ( 478) 382 81.2 5.3e-15 XP_016872445 (OMIM: 606665) PREDICTED: melanopsin ( 528) 382 81.3 5.6e-15 XP_016872446 (OMIM: 606665) PREDICTED: melanopsin ( 405) 361 77.2 7.1e-14 NP_001025186 (OMIM: 606665) melanopsin isoform 2 [ ( 489) 361 77.4 7.8e-14 XP_016872444 (OMIM: 606665) PREDICTED: melanopsin ( 539) 361 77.4 8.2e-14 NP_001048 (OMIM: 162321) substance-K receptor [Hom ( 398) 350 75.2 2.8e-13 NP_005949 (OMIM: 600665) melatonin receptor type 1 ( 350) 346 74.4 4.4e-13 NP_001050 (OMIM: 162332,614840) neuromedin-K recep ( 465) 338 73.1 1.4e-12 NP_001049 (OMIM: 162323) substance-P receptor isof ( 407) 327 71.0 5.3e-12 NP_001044 (OMIM: 182455) somatostatin receptor typ ( 364) 326 70.7 5.7e-12 NP_001166031 (OMIM: 182455) somatostatin receptor ( 364) 326 70.7 5.7e-12 XP_016865902 (OMIM: 609042) PREDICTED: opsin-5 iso ( 285) 324 70.2 6.5e-12 XP_016865901 (OMIM: 609042) PREDICTED: opsin-5 iso ( 285) 324 70.2 6.5e-12 NP_001041 (OMIM: 182452) somatostatin receptor typ ( 369) 323 70.2 8.4e-12 NP_001138757 (OMIM: 600018) mu-type opioid recepto ( 389) 314 68.6 2.7e-11 NP_001008504 (OMIM: 600018) mu-type opioid recepto ( 392) 314 68.6 2.7e-11 NP_056542 (OMIM: 162323) substance-P receptor isof ( 311) 313 68.3 2.7e-11 NP_001138755 (OMIM: 600018) mu-type opioid recepto ( 397) 314 68.6 2.7e-11 NP_000905 (OMIM: 600018) mu-type opioid receptor i ( 400) 314 68.6 2.8e-11 NP_001138756 (OMIM: 600018) mu-type opioid recepto ( 403) 314 68.6 2.8e-11 NP_001138754 (OMIM: 600018) mu-type opioid recepto ( 406) 314 68.6 2.8e-11 NP_001272452 (OMIM: 600018) mu-type opioid recepto ( 414) 314 68.6 2.8e-11 NP_001008503 (OMIM: 600018) mu-type opioid recepto ( 418) 314 68.6 2.8e-11 NP_001138758 (OMIM: 600018) mu-type opioid recepto ( 420) 314 68.6 2.8e-11 NP_001008505 (OMIM: 600018) mu-type opioid recepto ( 446) 314 68.7 2.9e-11 NP_000903 (OMIM: 165196) kappa-type opioid recepto ( 380) 313 68.4 3e-11 NP_004215 (OMIM: 300207) melatonin-related recepto ( 617) 315 69.1 3.1e-11 NP_001138751 (OMIM: 600018) mu-type opioid recepto ( 493) 314 68.8 3.1e-11 NP_001272453 (OMIM: 600018) mu-type opioid recepto ( 493) 314 68.8 3.1e-11 NP_001305426 (OMIM: 165196) kappa-type opioid rece ( 409) 313 68.4 3.2e-11 NP_005950 (OMIM: 125853,600804) melatonin receptor ( 362) 307 67.3 6.4e-11 XP_011541141 (OMIM: 125853,600804) PREDICTED: mela ( 362) 307 67.3 6.4e-11 XP_016865898 (OMIM: 609042) PREDICTED: opsin-5 iso ( 303) 305 66.8 7.5e-11 NP_001471 (OMIM: 600377) galanin receptor type 1 [ ( 349) 304 66.7 9.2e-11 NP_000902 (OMIM: 165195) delta-type opioid recepto ( 372) 303 66.5 1.1e-10 NP_057624 (OMIM: 605569) probable G-protein couple ( 423) 302 66.4 1.3e-10 NP_115940 (OMIM: 176400,604161,614837) kiSS-1 rece ( 398) 300 66.0 1.6e-10 XP_016874309 (OMIM: 602351) PREDICTED: chemokine-l ( 371) 299 65.8 1.8e-10 NP_004063 (OMIM: 602351) chemokine-like receptor 1 ( 371) 299 65.8 1.8e-10 NP_001135816 (OMIM: 602351) chemokine-like recepto ( 373) 299 65.8 1.8e-10 NP_001135815 (OMIM: 602351) chemokine-like recepto ( 373) 299 65.8 1.8e-10 >>NP_000504 (OMIM: 300821,303700,303800) medium-wave-sen (364 aa) initn: 2496 init1: 2496 opt: 2496 Z-score: 2486.4 bits: 468.7 E(85289): 9.4e-132 Smith-Waterman score: 2496; 100.0% identity (100.0% similar) in 364 aa overlap (1-364:1-364) 10 20 30 40 50 60 pF1KE1 MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 IFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYGYFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYGYFV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 LGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 AVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 QVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAANPGYPFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 QVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAANPGYPFH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 PLMAALPAFFAKSATIYNPVIYVFMNRQFRNCILQLFGKKVDDGSELSSASKTEVSSVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PLMAALPAFFAKSATIYNPVIYVFMNRQFRNCILQLFGKKVDDGSELSSASKTEVSSVSS 310 320 330 340 350 360 pF1KE1 VSPA :::: NP_000 VSPA >>NP_064445 (OMIM: 300822,303700,303900) long-wave-sensi (364 aa) initn: 2427 init1: 2427 opt: 2427 Z-score: 2418.0 bits: 456.0 E(85289): 6.1e-128 Smith-Waterman score: 2427; 96.4% identity (98.6% similar) in 364 aa overlap (1-364:1-364) 10 20 30 40 50 60 pF1KE1 MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 IFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYGYFV :::: :::::::::::::::::::::::::::::::::::::::::::::.:::: :::: NP_064 IFVVTASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISIVNQVSGYFV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 LGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 LGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 AVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYL ::::::::::::::::::::::::::::::::::::::::::::::::: ::.::.:::: NP_064 AVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCIIPLAIIMLCYL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 QVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAANPGYPFH :::::::::::::::::::::::::::::::::..:.: :::::.:::::::::::: :: NP_064 QVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMIFAYCVCWGPYTFFACFAAANPGYAFH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 PLMAALPAFFAKSATIYNPVIYVFMNRQFRNCILQLFGKKVDDGSELSSASKTEVSSVSS ::::::::.::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 PLMAALPAYFAKSATIYNPVIYVFMNRQFRNCILQLFGKKVDDGSELSSASKTEVSSVSS 310 320 330 340 350 360 pF1KE1 VSPA :::: NP_064 VSPA >>NP_001699 (OMIM: 190900,613522) short-wave-sensitive o (348 aa) initn: 1052 init1: 963 opt: 1033 Z-score: 1036.7 bits: 200.4 E(85289): 5.3e-51 Smith-Waterman score: 1033; 44.3% identity (74.8% similar) in 345 aa overlap (23-363:5-347) 10 20 30 40 50 60 pF1KE1 MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWM .. .. . : .:. ::..::.::::: :...: ...: NP_001 MRKMSEEEFYLFKNISSV-GPWDGPQYHIAPVWAFYLQAAFM 10 20 30 40 70 80 90 100 110 120 pF1KE1 IFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYGYFV : . . :..::.::...::::.:::.::::.. . . ... : . :::: NP_001 GTVFLIGFPLNAMVLVATLRYKKLRQPLNYILVNVSFGGFLLCIFSVFPVFVASCNGYFV 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE1 LGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWA .:. .:.:::. .. :.. ::::....::..:.:::::: ::..: :.. . .: . NP_001 FGRHVCALEGFLGTVAGLVTGWSLAFLAFERYIVICKPFGNFRFSSKHALTVVLATWTIG 110 120 130 140 150 160 190 200 210 220 230 pF1KE1 AVWTAPPIFGWSRYWPHGLKTSCGPDVFS-GSSYPGVQSYMIVLMVTCCITPLSIIVLCY . ::.:::::. :.::. ::::: .. :..: . .:: :.. : :.:::.: . : NP_001 IGVSIPPFFGWSRFIPEGLQCSCGPDWYTVGTKYRS-ESYTWFLFIFCFIVPLSLICFSY 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE1 LQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAANPGYPF :. :..::: ::.:: .:::::.::.::::::: .:: :. ::: :: . . : .. . NP_001 TQLLRALKAVAAQQQESATTQKAEREVSRMVVVMVGSFCVCYVPYAAFAMYMVNNRNHGL 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE1 HPLMAALPAFFAKSATIYNPVIYVFMNRQFRNCILQLF-GKKVDDGSELSSASKTEVSSV ....:.::.::: ::::.:: :::.::. ::... :: . : :. :..:::::.: NP_001 DLRLVTIPSFFSKSACIYNPIIYCFMNKQFQACIMKMVCGKAMTDESDTCSSQKTEVSTV 290 300 310 320 330 340 360 pF1KE1 SS--VSPA :: :.: NP_001 SSTQVGPN >>NP_000530 (OMIM: 136880,180380,610445,613731) rhodopsi (348 aa) initn: 977 init1: 977 opt: 1002 Z-score: 1006.0 bits: 194.7 E(85289): 2.7e-49 Smith-Waterman score: 1002; 44.3% identity (74.2% similar) in 345 aa overlap (21-359:2-346) 10 20 30 40 50 pF1KE1 MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNST---RGPFEGPNYHIAPRWVYHLTS ..:.. : ::.: :.::: :.:..: : . . . NP_000 MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLA 10 20 30 40 60 70 80 90 100 110 pF1KE1 VWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYG ..:..... . : :.: .:.. :::: :::.::.::::::: .. . : .. ....: NP_000 AYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHG 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 YFVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSW :::.: : :::. ..: : .::::.... ::..:::::..: :: . ::.:.::.: NP_000 YFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTW 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 IWAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVL . : . .:::. ::::: :.::. ::: : .. . . .:..: ..:. :. :: . NP_000 VMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFF 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE1 CYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAANPGY :: :. .... .: ::.:: .::::::::::::..::.:: .:: ::: : . .. : NP_000 CYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGS 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE1 PFHPLMAALPAFFAKSATIYNPVIYVFMNRQFRNCILQLF--GKK-VDDGSELSSASKTE : :.. ..::::::::.:::::::..::.:::::.: . ::. . : ...:::: NP_000 NFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATVSKTE 290 300 310 320 330 340 360 pF1KE1 VSSVSSVSPA .:.:. NP_000 TSQVAPA >>NP_055137 (OMIM: 606695) opsin-3 [Homo sapiens] (402 aa) initn: 523 init1: 223 opt: 512 Z-score: 519.8 bits: 104.9 E(85289): 3.3e-22 Smith-Waterman score: 512; 30.9% identity (64.3% similar) in 311 aa overlap (38-337:23-324) 10 20 30 40 50 60 pF1KE1 QRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRW---VYHLTSVWMIFVV :: . . :: . .:. .. . . NP_055 MYSGNRSGGHGYWDGGGAAGAEGPAPAGTLSPAPLFSPGTYERLALLLGSIG 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 IASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYGYFVLGHP . .: .: :::. .::..:: : . .:::....:: .... :.. :. . . .: NP_055 LLGVGNNLLVLVLYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDTV 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 MCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWAAVWT :: .:.. :: ::... .:.....::.. : . . :. : .:.. :... .:. NP_055 GCVWDGFSGSLFGIVSIATLTVLAYERYIRVVHAR-VINFS--WAWRAITYIWLYSLAWA 120 130 140 150 160 190 200 210 220 230 240 pF1KE1 APPIFGWSRYW--PHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQV . :..::.:: ::: .: : : .. .:... :.. : ..::..:. :: .. NP_055 GAPLLGWNRYILDVHGL--GCTVDWKSKDAND--SSFVLFLFLGCLVVPLGVIAHCYGHI 170 180 190 200 210 220 250 260 270 280 290 pF1KE1 WLAIRAVAKQQKESESTQ-----KAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAANP-G .:: . . .. .. : : ::....: .:...: :: :: . :: ..: : NP_055 LYSIRML-RCVEDLQTIQVIKILKYEKKLAKMCFLMIFTFLVCWMPY-IVICFLVVNGHG 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE1 YPFHPLMAALPAFFAKSATIYNPVIYVFMNRQFRNCILQLFGKKVDDGSELSSASKTEVS . : .. . .:::: :.::::::::: :.:: .:::. NP_055 HLVTPTISIVSYLFAKSNTVYNPVIYVFMIRKFRRSLLQLLCLRLLRCQRPAKDLPAAGS 290 300 310 320 330 340 360 pF1KE1 SVSSVSPA NP_055 EMQIRPIVMSQKDGDRPKKKVTFNSSSIIFIITSDESLSVDDSDKTNGSKVDVIQVRPL 350 360 370 380 390 400 >>NP_006574 (OMIM: 605224) visual pigment-like receptor (337 aa) initn: 425 init1: 425 opt: 507 Z-score: 515.6 bits: 103.9 E(85289): 5.6e-22 Smith-Waterman score: 507; 28.3% identity (65.1% similar) in 307 aa overlap (53-356:25-328) 30 40 50 60 70 80 pF1KE1 TQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWMIFVVIASVFTNGLVLAATMKFK ........:.. . :...: .::. .:.: NP_006 MLRNNLGNSSDSKNEDGSVFSQTEHNIVATYLIMAGMISIISNIIVLGIFIKYK 10 20 30 40 50 90 100 110 120 130 140 pF1KE1 KLRHPLNWILVNLAVADLAETVIASTISVVNQVYGYFVLGHPMC-VLEGYTVSLCGITGL .:: : : :..::::.:.. . :. .:.....:: . .:. : : : .. . :.... NP_006 ELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQVYAGLNI-FFGMASI 60 70 80 90 100 110 150 160 170 180 190 200 pF1KE1 WSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWAAVWTAPPIFGWSRYWPHGLKT :.... .:....: : . :. .. : : .:: . :. ::.::. : : . NP_006 GLLTVVAVDRYLTICLPDVGRRMTTNTYIGLILGAWINGLFWALMPIIGWASYAPDPTGA 120 130 140 150 160 170 210 220 230 240 250 260 pF1KE1 SCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIRA-VAKQQKESESTQ .: . ... . :: ..... :.::... :: .: :.:. .... :: . . NP_006 TCTINWRKNDR--SFVSYTMTVIAINFIVPLTVMFYCYYHVTLSIKHHTTSDCTESLNRD 180 190 200 210 220 230 270 280 290 300 310 pF1KE1 KAEK-EVTRMVVVMVLAFCFCWGPYAFFACFAAANPGYPFHPLMAALPAFFAKSATIYNP ... .::.: :.:. : :.::.. .:. . . : :: . .::::.:.::: NP_006 WSDQIDVTKMSVIMICMFLVAWSPYSIVCLWASFGDPKKIPPPMAIIAPLFAKSSTFYNP 240 250 260 270 280 290 320 330 340 350 360 pF1KE1 VIYVFMNRQFRNCILQLFGKKVDDGSELSSASKTEVSSVSSVSPA ::: :..:: .: .: .. . ..: .:: NP_006 CIYVVANKKFRRAMLAMFKCQTHQTMPVTSILPMDVSQNPLASGRI 300 310 320 330 >>NP_859528 (OMIM: 609042) opsin-5 [Homo sapiens] (354 aa) initn: 409 init1: 282 opt: 446 Z-score: 454.9 bits: 92.7 E(85289): 1.3e-18 Smith-Waterman score: 446; 26.2% identity (61.2% similar) in 317 aa overlap (51-357:30-344) 30 40 50 60 70 pF1KE1 DSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWMIFVV-IASVFTNGLVLAATM : :.. ... .. : :.: :: :: . NP_859 MALNHTALPQDERLPHYLRDGDPFASKLSWEADLVAGFYLTIIGILSTFGNGYVLYMSS 10 20 30 40 50 80 90 100 110 120 130 pF1KE1 KFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYGYFVLGHPMCVLEGYTVSLCGIT . :: .: . . .:::: ::. .:... ..... .:.: : :.. . : NP_859 RRKKKLRPAEIMTINLAVCDLGISVVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFFGCG 60 70 80 90 100 110 140 150 160 170 180 190 pF1KE1 GLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWAAVWTAPPIFGWSRYWPHGL .: ... .: .:.. .: .: . : : . .: : .:. ::. :. : . : :. . NP_859 SLITMTAVSLDRYLKICYLSYGVWLKRKHAYICLAAIWAYASFWTTMPLVGLGDYVPEPF 120 130 140 150 160 170 200 210 220 230 240 250 pF1KE1 KTSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIRAVAKQ----QKE ::: : . ... : : ... .. : . : ..::. :... ... .:. ... NP_859 GTSCTLDWWLAQASVGGQVFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSR 180 190 200 210 220 230 260 270 280 290 300 310 pF1KE1 SESTQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAANPGYPFH-PL-MAALPAFFAKS .:.. : ..:...... .: . : ::: . ..: : : :. ....:...::: NP_859 IHSSHVLEMKLTKVAMLICAGFLIAWIPYAVVSVWSAF--GRPDSIPIQLSVVPTLLAKS 240 250 260 270 280 290 320 330 340 350 360 pF1KE1 ATIYNPVIYVFMNRQFRNCI---LQLFGKKVDDGSELSSASKTEVSSVSSVSPA :..:::.:: .. .: : :. :: .: .: ... .. :: NP_859 AAMYNPIIYQVIDYKFACCQTGGLKATKKKSLEGFRLHTVTTVRKSSAVLEIHEEWE 300 310 320 330 340 350 >>XP_016865905 (OMIM: 609042) PREDICTED: opsin-5 isoform (408 aa) initn: 409 init1: 282 opt: 446 Z-score: 454.3 bits: 92.8 E(85289): 1.4e-18 Smith-Waterman score: 446; 26.2% identity (61.2% similar) in 317 aa overlap (51-357:30-344) 30 40 50 60 70 pF1KE1 DSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWMIFVV-IASVFTNGLVLAATM : :.. ... .. : :.: :: :: . XP_016 MALNHTALPQDERLPHYLRDGDPFASKLSWEADLVAGFYLTIIGILSTFGNGYVLYMSS 10 20 30 40 50 80 90 100 110 120 130 pF1KE1 KFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYGYFVLGHPMCVLEGYTVSLCGIT . :: .: . . .:::: ::. .:... ..... .:.: : :.. . : XP_016 RRKKKLRPAEIMTINLAVCDLGISVVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFFGCG 60 70 80 90 100 110 140 150 160 170 180 190 pF1KE1 GLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWAAVWTAPPIFGWSRYWPHGL .: ... .: .:.. .: .: . : : . .: : .:. ::. :. : . : :. . XP_016 SLITMTAVSLDRYLKICYLSYGVWLKRKHAYICLAAIWAYASFWTTMPLVGLGDYVPEPF 120 130 140 150 160 170 200 210 220 230 240 250 pF1KE1 KTSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIRAVAKQ----QKE ::: : . ... : : ... .. : . : ..::. :... ... .:. ... XP_016 GTSCTLDWWLAQASVGGQVFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSR 180 190 200 210 220 230 260 270 280 290 300 310 pF1KE1 SESTQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAANPGYPFH-PL-MAALPAFFAKS .:.. : ..:...... .: . : ::: . ..: : : :. ....:...::: XP_016 IHSSHVLEMKLTKVAMLICAGFLIAWIPYAVVSVWSAF--GRPDSIPIQLSVVPTLLAKS 240 250 260 270 280 290 320 330 340 350 360 pF1KE1 ATIYNPVIYVFMNRQFRNCI---LQLFGKKVDDGSELSSASKTEVSSVSSVSPA :..:::.:: .. .: : :. :: .: .: ... .. :: XP_016 AAMYNPIIYQVIDYKFACCQTGGLKATKKKSLEGFRLHTVTTVRKSSAVLEIHEEDKGRL 300 310 320 330 340 350 XP_016 WHQLSCGENSEMTASSETLGTKAHSPLQETREGENEAVGGNNKCSGCEECI 360 370 380 390 400 >>XP_016865900 (OMIM: 609042) PREDICTED: opsin-5 isoform (298 aa) initn: 388 init1: 261 opt: 409 Z-score: 419.0 bits: 85.8 E(85289): 1.3e-16 Smith-Waterman score: 409; 26.7% identity (61.8% similar) in 285 aa overlap (82-357:7-288) 60 70 80 90 100 110 pF1KE1 VYHLTSVWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISV :::: : . . .:::: ::. .:... ... XP_016 MSSRRKKKLR-PAEIMTINLAVCDLGISVVGKPFTI 10 20 30 120 130 140 150 160 170 pF1KE1 VNQVYGYFVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIV .. .:.: : :.. . : .: ... .: .:.. .: .: . : : . XP_016 ISCFCHRWVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSYGVWLKRKHAYI 40 50 60 70 80 90 180 190 200 210 220 230 pF1KE1 GIAFSWIWAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCITP .: : .:. ::. :. : . : :. . ::: : . ... : : ... .. : . : XP_016 CLAAIWAYASFWTTMPLVGLGDYVPEPFGTSCTLDWWLAQASVGGQVFILNILFFCLLLP 100 110 120 130 140 150 240 250 260 270 280 pF1KE1 LSIIVLCYLQVWLAIRAVAKQ----QKESESTQKAEKEVTRMVVVMVLAFCFCWGPYAFF ..::. :... ... .:. ... .:.. : ..:...... .: . : ::: XP_016 TAVIVFSYVKIIAKVKSSSKEVAHFDSRIHSSHVLEMKLTKVAMLICAGFLIAWIPYAVV 160 170 180 190 200 210 290 300 310 320 330 340 pF1KE1 ACFAAANPGYPFH-PL-MAALPAFFAKSATIYNPVIYVFMNRQFRNCI---LQLFGKKVD . ..: : : :. ....:...::::..:::.:: .. .: : :. :: XP_016 SVWSAF--GRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYKFACCQTGGLKATKKKSL 220 230 240 250 260 270 350 360 pF1KE1 DGSELSSASKTEVSSVSSVSPA .: .: ... .. :: XP_016 EGFRLHTVTTVRKSSAVLEIHEEWE 280 290 >>NP_150598 (OMIM: 606665) melanopsin isoform 1 [Homo sa (478 aa) initn: 426 init1: 144 opt: 382 Z-score: 390.3 bits: 81.2 E(85289): 5.3e-15 Smith-Waterman score: 514; 28.6% identity (63.9% similar) in 346 aa overlap (18-335:27-363) 10 20 30 40 pF1KE1 MAQQWSLQRLAGRHPQDSYEDSTQSSIFTY----TNSNSTRGPFEG----- :. ::.:::: . . : .. : . . NP_150 MNPPSGPRVPPSPTQEPSCMATPAPPSWWDSSQSSISSLGRLPSISPTAPGTWAAAWVPL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE1 PNYHIAPRWVYHLTSVWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAE :. . . : : .: ...: ..... : :. . . ..:: : : ...::::.:. NP_150 PTVDVPDHAHYTLGTV-ILLVGLTGMLGNLTVIYTFCRSRSLRTPANMFIINLAVSDFLM 70 80 90 100 110 110 120 130 140 150 pF1KE1 TVIASTISVVNQVYGYFVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKP---F . . . ....: ...:. : . .. .: ::... .:. :. .:..:. .: : NP_150 SFTQAPVFFTSSLYKQWLFGETGCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATF 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE1 GNV-RFDAKLAIVGIAFSWIWAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQS : . . : ....:. :..: .:. ::.:::: : :.:: :::. : .: . :.:.. NP_150 GVASKRRAAFVLLGV---WLYALAWSLPPFFGWSAYVPEGLLTSCSWDYMSFT--PAVRA 180 190 200 210 220 230 220 230 240 250 260 pF1KE1 YMIVLMVTCCIT---PLSIIVLCYLQVWLAIRAVAKQQK-------ESEST---QKAEKE : ..: ::.. :: ::. ::. .. ::: ... . ..:: :. ..: NP_150 YTMLL---CCFVFFLPLLIIIYCYIFIFRAIRETGRALQTFGACKGNGESLWQRQRLQSE 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE1 --VTRMVVVMVLAFCFCWGPYAFFACFAAANPGYPFHPLMAALPAFFAKSATIYNPVIYV .........: : . :.::. : : :. .. . : :...:: .::...:.::.::. NP_150 CKMAKIMLLVILLFVLSWAPYSAVALVAFAGYAHVLTPYMSSVPAVIAKASAIHNPIIYA 300 310 320 330 340 350 330 340 350 360 pF1KE1 FMNRQFRNCILQLFGKKVDDGSELSSASKTEVSSVSSVSPA . . ..: : : NP_150 ITHPKYRVAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHRSTLTSHTSNLSWISIRRRQES 360 370 380 390 400 410 364 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 18:01:20 2016 done: Mon Nov 7 18:01:21 2016 Total Scan time: 7.520 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]