FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9558, 477 aa 1>>>pF1KE9558 477 - 477 aa - 477 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4065+/-0.000336; mu= 18.0240+/- 0.021 mean_var=79.7579+/-15.948, 0's: 0 Z-trim(117.2): 225 B-trim: 626 in 2/50 Lambda= 0.143611 statistics sampled from 28738 (28968) to 28738 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.701), E-opt: 0.2 (0.34), width: 16 Scan time: 9.290 The best scores are: opt bits E(85289) NP_000151 (OMIM: 125853,138033) glucagon receptor ( 477) 3324 698.2 1.3e-200 XP_006722340 (OMIM: 125853,138033) PREDICTED: gluc ( 477) 3324 698.2 1.3e-200 XP_016879935 (OMIM: 125853,138033) PREDICTED: gluc ( 475) 3293 691.8 1.1e-198 XP_011521841 (OMIM: 125853,138033) PREDICTED: gluc ( 444) 2634 555.3 1.3e-157 XP_016879936 (OMIM: 125853,138033) PREDICTED: gluc ( 355) 2373 501.1 2.1e-141 NP_002053 (OMIM: 138032) glucagon-like peptide 1 r ( 463) 1425 304.8 3.4e-82 XP_016866239 (OMIM: 138032) PREDICTED: glucagon-li ( 468) 1416 302.9 1.2e-81 NP_004237 (OMIM: 603659) glucagon-like peptide 2 r ( 553) 1231 264.6 4.9e-70 XP_016880828 (OMIM: 603659) PREDICTED: glucagon-li ( 559) 1209 260.1 1.2e-68 NP_000155 (OMIM: 137241) gastric inhibitory polype ( 466) 1191 256.3 1.3e-67 NP_001295347 (OMIM: 137241) gastric inhibitory pol ( 430) 1186 255.2 2.6e-67 XP_011522379 (OMIM: 603659) PREDICTED: glucagon-li ( 578) 1028 222.6 2.3e-57 XP_005256918 (OMIM: 603659) PREDICTED: glucagon-li ( 400) 993 215.2 2.6e-55 XP_016880830 (OMIM: 603659) PREDICTED: glucagon-li ( 448) 993 215.3 2.9e-55 XP_016880829 (OMIM: 603659) PREDICTED: glucagon-li ( 483) 993 215.3 3.1e-55 XP_005249618 (OMIM: 601970) PREDICTED: vasoactive ( 463) 815 178.4 3.7e-44 NP_001295188 (OMIM: 601970) vasoactive intestinal ( 422) 814 178.2 4e-44 NP_003373 (OMIM: 601970) vasoactive intestinal pol ( 438) 814 178.2 4.1e-44 XP_006716171 (OMIM: 601970) PREDICTED: vasoactive ( 392) 791 173.4 1e-42 XP_011514852 (OMIM: 601970) PREDICTED: vasoactive ( 439) 791 173.4 1.1e-42 XP_006716170 (OMIM: 601970) PREDICTED: vasoactive ( 455) 791 173.4 1.2e-42 XP_016868069 (OMIM: 601970) PREDICTED: vasoactive ( 300) 767 168.3 2.6e-41 XP_016866240 (OMIM: 138032) PREDICTED: glucagon-li ( 287) 743 163.3 8e-40 NP_002971 (OMIM: 182098) secretin receptor precurs ( 440) 718 158.3 4e-38 XP_005263787 (OMIM: 182098) PREDICTED: secretin re ( 262) 704 155.2 2e-37 XP_016860161 (OMIM: 182098) PREDICTED: secretin re ( 377) 701 154.7 4.1e-37 XP_016860159 (OMIM: 182098) PREDICTED: secretin re ( 435) 701 154.8 4.6e-37 XP_011509923 (OMIM: 182098) PREDICTED: secretin re ( 445) 701 154.8 4.7e-37 NP_001238813 (OMIM: 192321) vasoactive intestinal ( 409) 698 154.1 6.8e-37 XP_005265496 (OMIM: 192321) PREDICTED: vasoactive ( 410) 698 154.1 6.8e-37 NP_001238811 (OMIM: 192321) vasoactive intestinal ( 416) 698 154.1 6.8e-37 XP_005265495 (OMIM: 192321) PREDICTED: vasoactive ( 416) 698 154.1 6.8e-37 XP_011532381 (OMIM: 192321) PREDICTED: vasoactive ( 416) 698 154.1 6.8e-37 NP_001238814 (OMIM: 192321) vasoactive intestinal ( 430) 698 154.1 7e-37 XP_005265494 (OMIM: 192321) PREDICTED: vasoactive ( 456) 698 154.1 7.3e-37 NP_004615 (OMIM: 192321) vasoactive intestinal pol ( 457) 698 154.1 7.4e-37 XP_016860162 (OMIM: 182098) PREDICTED: secretin re ( 267) 687 151.7 2.4e-36 XP_016860160 (OMIM: 182098) PREDICTED: secretin re ( 409) 687 151.8 3.3e-36 NP_001291451 (OMIM: 601970) vasoactive intestinal ( 358) 648 143.7 8e-34 XP_005249675 (OMIM: 102981) PREDICTED: pituitary a ( 411) 645 143.1 1.4e-33 NP_001186566 (OMIM: 102981) pituitary adenylate cy ( 447) 645 143.2 1.5e-33 NP_001109 (OMIM: 102981) pituitary adenylate cycla ( 468) 645 143.2 1.5e-33 XP_016882076 (OMIM: 137241) PREDICTED: gastric inh ( 302) 626 139.1 1.7e-32 NP_001158209 (OMIM: 114131,166710) calcitonin rece ( 508) 621 138.2 5.1e-32 XP_005265401 (OMIM: 125350,156400,168468,215045,60 ( 562) 594 132.7 2.6e-30 NP_001171673 (OMIM: 125350,156400,168468,215045,60 ( 593) 594 132.7 2.8e-30 XP_016862422 (OMIM: 125350,156400,168468,215045,60 ( 593) 594 132.7 2.8e-30 NP_000307 (OMIM: 125350,156400,168468,215045,60000 ( 593) 594 132.7 2.8e-30 XP_011532270 (OMIM: 125350,156400,168468,215045,60 ( 600) 594 132.7 2.8e-30 XP_011532269 (OMIM: 125350,156400,168468,215045,60 ( 606) 594 132.7 2.8e-30 >>NP_000151 (OMIM: 125853,138033) glucagon receptor prec (477 aa) initn: 3324 init1: 3324 opt: 3324 Z-score: 3722.9 bits: 698.2 E(85289): 1.3e-200 Smith-Waterman score: 3324; 100.0% identity (100.0% similar) in 477 aa overlap (1-477:1-477) 10 20 30 40 50 60 pF1KE9 MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 TFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL 370 380 390 400 410 420 430 440 450 460 470 pF1KE9 GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF 430 440 450 460 470 >>XP_006722340 (OMIM: 125853,138033) PREDICTED: glucagon (477 aa) initn: 3324 init1: 3324 opt: 3324 Z-score: 3722.9 bits: 698.2 E(85289): 1.3e-200 Smith-Waterman score: 3324; 100.0% identity (100.0% similar) in 477 aa overlap (1-477:1-477) 10 20 30 40 50 60 pF1KE9 MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 TFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL 370 380 390 400 410 420 430 440 450 460 470 pF1KE9 GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF 430 440 450 460 470 >>XP_016879935 (OMIM: 125853,138033) PREDICTED: glucagon (475 aa) initn: 3189 init1: 3189 opt: 3293 Z-score: 3688.2 bits: 691.8 E(85289): 1.1e-198 Smith-Waterman score: 3293; 99.6% identity (99.6% similar) in 477 aa overlap (1-477:1-475) 10 20 30 40 50 60 pF1KE9 MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNR ::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::: XP_016 MPPCQPQRPLLLLLLLLAC--QVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNR 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 TFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE9 FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE9 WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE9 MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE9 HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL 360 370 380 390 400 410 430 440 450 460 470 pF1KE9 GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF 420 430 440 450 460 470 >>XP_011521841 (OMIM: 125853,138033) PREDICTED: glucagon (444 aa) initn: 2634 init1: 2634 opt: 2634 Z-score: 2950.7 bits: 555.3 E(85289): 1.3e-157 Smith-Waterman score: 2634; 100.0% identity (100.0% similar) in 387 aa overlap (91-477:58-444) 70 80 90 100 110 120 pF1KE9 TFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ :::::::::::::::::::::::::::::: XP_011 GQSWCATEPSTSIPAGRTPPPIPRPTSPAPVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ 30 40 50 60 70 80 130 140 150 160 170 180 pF1KE9 CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL 90 100 110 120 130 140 190 200 210 220 230 240 pF1KE9 FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC 150 160 170 180 190 200 250 260 270 280 290 300 pF1KE9 WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN 210 220 230 240 250 260 310 320 330 340 350 360 pF1KE9 MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV 270 280 290 300 310 320 370 380 390 400 410 420 pF1KE9 HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL 330 340 350 360 370 380 430 440 450 460 470 pF1KE9 GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF 390 400 410 420 430 440 >>XP_016879936 (OMIM: 125853,138033) PREDICTED: glucagon (355 aa) initn: 2373 init1: 2373 opt: 2373 Z-score: 2659.8 bits: 501.1 E(85289): 2.1e-141 Smith-Waterman score: 2373; 100.0% identity (100.0% similar) in 355 aa overlap (123-477:1-355) 100 110 120 130 140 150 pF1KE9 HRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLS :::::::::::::::::::::::::::::: XP_016 MDGEEIEVQKEVAKMYSSFQVMYTVGYSLS 10 20 30 160 170 180 190 200 210 pF1KE9 LGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSV 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE9 STWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGW 100 110 120 130 140 150 280 290 300 310 320 330 pF1KE9 GAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAK 160 170 180 190 200 210 340 350 360 370 380 390 pF1KE9 LRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQ 220 230 240 250 260 270 400 410 420 430 440 450 pF1KE9 GLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGR 280 290 300 310 320 330 460 470 pF1KE9 GGGSQDSSAETPLAGGLPRLAESPF ::::::::::::::::::::::::: XP_016 GGGSQDSSAETPLAGGLPRLAESPF 340 350 >>NP_002053 (OMIM: 138032) glucagon-like peptide 1 recep (463 aa) initn: 1373 init1: 861 opt: 1425 Z-score: 1596.7 bits: 304.8 E(85289): 3.4e-82 Smith-Waterman score: 1425; 47.5% identity (73.9% similar) in 463 aa overlap (9-461:7-456) 10 20 30 40 50 pF1KE9 MPPCQPQRPLLLLLLLLAC------QPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPP- :: : ::::. .:: .... . . .::. : ::...:. ::: NP_002 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETV-QKWREYRRQCQRSLTEDPPPA 10 20 30 40 50 60 70 80 90 100 110 pF1KE9 TELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQ :.: ::::::.:.:::: .. .:.:::::::: .: . :.. : .: :.. .. NP_002 TDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 -PWRDASQCQMD--GEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLH :::: :.:. . ::. .... .: ..:::::.::..::..: ::: :. .:: NP_002 LPWRDLSECEESKRGERSSPEEQLLFLY----IIYTVGYALSFSALVIASAILLGFRHLH 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE9 CTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVF :::: :: ::::::.:.: ::.. :. :. :: ... . . :: .::.. .. NP_002 CTRNYIHLNLFASFILRALSVFIKDAALKWMYSTA-AQQHQWDGLLSYQDSLSCRLVFLL 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE9 MQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFE ::: ..::: ::::::.::..::....: :. .: ::..::::.:.::::::..:: :.: NP_002 MQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYE 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE9 NVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKS . ::: :.::..: :.:.:...:: .::.::::.. ..:.::.: : .:: : ::::: NP_002 DEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKS 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE9 TLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSE :::::::::.:::.:::: ::::.:::: ::: .: ..:::::.::.::::.:.::: : NP_002 TLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLE 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE9 LRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLP .:. :.:::: .. .: :: :.. :. : .::. .: NP_002 FRKSWERWRL-------EHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 420 430 440 450 460 pF1KE9 RLAESPF >>XP_016866239 (OMIM: 138032) PREDICTED: glucagon-like p (468 aa) initn: 1373 init1: 861 opt: 1416 Z-score: 1586.6 bits: 302.9 E(85289): 1.2e-81 Smith-Waterman score: 1416; 48.3% identity (73.9% similar) in 449 aa overlap (21-461:25-461) 10 20 30 40 50 pF1KE9 MPPCQPQRPLLLLLLLLACQPQVPSAQVMDF-LFE---KWKLYGDQCHHNLSLLPP : .:: : :.: ::. : ::...:. :: XP_016 MEIEKPSVLGGEGAGEGLAEPTGLPYMPSPQGATVSLWETVQKWREYRRQCQRSLTEDPP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE9 P-TELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPR : :.: ::::::.:.:::: .. .:.:::::::: .: . :.. : .: :.. XP_016 PATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDN 70 80 90 100 110 120 120 130 140 150 160 pF1KE9 GQ-PWRDASQCQMD--GEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSK .. :::: :.:. . ::. .... .: ..:::::.::..::..: ::: :. . XP_016 SSLPWRDLSECEESKRGERSSPEEQLLFLY----IIYTVGYALSFSALVIASAILLGFRH 130 140 150 160 170 170 180 190 200 210 220 pF1KE9 LHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAA :::::: :: ::::::.:.: ::.. :. :. :: ... . . :: .::.. XP_016 LHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTA-AQQHQWDGLLSYQDSLSCRLVF 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE9 VFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCL ..::: ..::: ::::::.::..::....: :. .: ::..::::.:.::::::..:: : XP_016 LLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYL 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE9 FENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLA .:. ::: :.::..: :.:.:...:: .::.::::.. ..:.::.: : .:: : ::: XP_016 YEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLA 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE9 KSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQ :::::::::::.:::.:::: ::::.:::: ::: .: ..:::::.::.::::.:.::: XP_016 KSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQ 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE9 SELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGG :.:. :.:::: .. .: :: :.. :. : .::. .: XP_016 LEFRKSWERWRL-------EHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 420 430 440 450 460 470 pF1KE9 LPRLAESPF >>NP_004237 (OMIM: 603659) glucagon-like peptide 2 recep (553 aa) initn: 1126 init1: 756 opt: 1231 Z-score: 1378.4 bits: 264.6 E(85289): 4.9e-70 Smith-Waterman score: 1231; 44.9% identity (74.1% similar) in 421 aa overlap (6-422:48-458) 10 20 30 pF1KE9 MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEK : ::.: :.::.. . :: ...... .: NP_004 LPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVSIK-QV-TGSLLEETTRK 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE9 WKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWP-DTPANTTANISCPWYLPWHHKVQHR : : . : ..: : :. . :: :::.: ::: ..:.:.. . :: :::: . . NP_004 WAQYKQACLRDL--LKEPSGIFCNGTFDQYVCWPHSSPGNVS--VPCPSYLPWWSEESSG 80 90 100 110 120 130 100 110 120 130 140 150 pF1KE9 FVFKRCGPDGQWVRGPRGQP-WRDASQCQMDGEEIEVQKEVAK--MYSSFQVMYTVGYSL ....: .: : . :.: :.:. :. ...: . . :..:.:::::::. NP_004 RAYRHCLAQGTWQTIENATDIWQDDSECS---ENHSFKQNVDRYALLSTLQLMYTVGYSF 140 150 160 170 180 160 170 180 190 200 210 pF1KE9 SLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLS :: .:.:::..: : ::::::: :: ::::::.:.. .::: : .. . ::.. .. . NP_004 SLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKRPDNENG 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE9 VSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIG ..::. ... :: . :...: . ::: ::::::::::.:: ..:::: .. :: .: NP_004 WMSYLSEMSTS-CRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLG 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE9 WGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVA :. :.::::::. .. .::. :::.: : .:::.: :..: . .:::::..:..::.. NP_004 WAFPVLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLIS 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE9 KLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSF ::.:.:: :::.:::::::.:::::::::..:.:.::....: . .::..: :::: NP_004 KLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSF 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE9 QGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFG .:.:::. : : : ::..:::. : :. :.. NP_004 HGFLVALQYGFANGEVKAELRKYWVRFLLARHSGCRACVLGKDFRFLGKCPKKLSEGDGA 430 440 450 460 470 480 460 470 pF1KE9 RGGGSQDSSAETPLAGGLPRLAESPF NP_004 EKLRKLQPSLNSGRLLHLAMRGLGELGAQPQQDHARWPRGSSLSECSEGDVTMANTMEEI 490 500 510 520 530 540 >>XP_016880828 (OMIM: 603659) PREDICTED: glucagon-like p (559 aa) initn: 1110 init1: 756 opt: 1209 Z-score: 1353.7 bits: 260.1 E(85289): 1.2e-68 Smith-Waterman score: 1209; 44.3% identity (73.1% similar) in 427 aa overlap (6-422:48-464) 10 20 30 pF1KE9 MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEK : ::.: :.::.. . :: ...... .: XP_016 LPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVSIK-QV-TGSLLEETTRK 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE9 WKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWP-DTPANTTANISCPWYLPWHHKVQHR : : . : ..: : :. . :: :::.: ::: ..:.:.. . :: :::: . XP_016 WAQYKQACLRDL--LKEPSGIFCNGTFDQYVCWPHSSPGNVS--VPCPSYLPWWSEELCL 80 90 100 110 120 130 100 110 120 130 140 pF1KE9 F------VFKRCGPDGQWVRGPRGQP-WRDASQCQMDGEEIEVQKEVAK--MYSSFQVMY . ....: .: : . :.: :.:. :. ...: . . :..:.:: XP_016 LSESSGRAYRHCLAQGTWQTIENATDIWQDDSECS---ENHSFKQNVDRYALLSTLQLMY 140 150 160 170 180 150 160 170 180 190 200 pF1KE9 TVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQK :::::.:: .:.:::..: : ::::::: :: ::::::.:.. .::: : .. . ::.. XP_016 TVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKR 190 200 210 220 230 240 210 220 230 240 250 260 pF1KE9 IGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFS .. . ..::. ... :: . :...: . ::: ::::::::::.:: ..:::: .. XP_016 PDNENGWMSYLSEMSTS-CRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWP 250 260 270 280 290 300 270 280 290 300 310 320 pF1KE9 LYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRI :: .::. :.::::::. .. .::. :::.: : .:::.: :..: . .:::::..: XP_016 RYLLLGWAFPVLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLKI 310 320 330 340 350 360 330 340 350 360 370 380 pF1KE9 VQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFD ..::..::.:.:: :::.:::::::.:::::::::..:.:.::....: . .::.. XP_016 LKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFIQ 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE9 LFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPS : ::::.:.:::. : : : ::..:::. : :. :.. XP_016 LTLSSFHGFLVALQYGFANGEVKAELRKYWVRFLLARHSGCRACVLGKDFRFLGKCPKKL 430 440 450 460 470 480 450 460 470 pF1KE9 KELQFGRGGGSQDSSAETPLAGGLPRLAESPF XP_016 SEGDGAEKLRKLQPSLNSGRLLHLAMRGLGELGAQPQQDHARWPRGSSLSECSEGDVTMA 490 500 510 520 530 540 >>NP_000155 (OMIM: 137241) gastric inhibitory polypeptid (466 aa) initn: 1437 init1: 894 opt: 1191 Z-score: 1334.6 bits: 256.3 E(85289): 1.3e-67 Smith-Waterman score: 1491; 50.4% identity (73.2% similar) in 466 aa overlap (9-459:5-459) 10 20 30 40 50 pF1KE9 MPPCQPQRPLLLLLLLLA-CQPQVPSA------QVMDFLFEKWKLYGDQCHHNLSLLPPP :.: ::: :. : . : :. :...:. : .:...:. :: NP_000 MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPP 10 20 30 40 50 60 70 80 90 100 110 pF1KE9 TELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQ . :.:: .:: : :: . :.:: ::::::::::.: ::...:: :::: : NP_000 SGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQW-----GL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 PWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTR ::: .::. . :. :. . . .::::::::::::..::::: ::. . .::::: NP_000 -WRDHTQCE-NPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTR 120 130 140 150 160 180 190 200 210 220 230 pF1KE9 NAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQY : :: :::.::.:.:...: : :: : . .::. ... : . :.:.::.: . :: NP_000 NYIHINLFTSFMLRAAAILSRDRLL-PRPGPYLGDQ-ALALW--NQALAACRTAQIVTQY 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE9 GIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQ . ::: ::::::.:::.:: :. :.. : :: .::::: :::.::..:. :.::.: NP_000 CVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQ 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE9 CWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLT :: :. ..:::.: :....:::::.::.::. .:..:::.:::. ::..:::.:::: NP_000 CWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLT 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE9 LIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRR :.::::::::::: ::.:.:.:.:: ::: :..:::::::.::.:::::.:::::::.:: NP_000 LVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRR 350 360 370 380 390 400 420 430 440 450 460 pF1KE9 RWHRWRLGKVLWEERNTSNHRA------SSSPGHGPPSKELQFGR--GGGSQDSSAETPL ::. :: . : ::. .:: .:.::. : :. :. : : :.. : NP_000 GWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESY 410 420 430 440 450 460 470 pF1KE9 AGGLPRLAESPF NP_000 C 477 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 17:59:49 2016 done: Mon Nov 7 17:59:51 2016 Total Scan time: 9.290 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]