FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9544, 466 aa 1>>>pF1KE9544 466 - 466 aa - 466 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7469+/-0.000349; mu= 15.5015+/- 0.022 mean_var=77.9499+/-15.813, 0's: 0 Z-trim(115.7): 274 B-trim: 1381 in 1/51 Lambda= 0.145267 statistics sampled from 25984 (26281) to 25984 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.668), E-opt: 0.2 (0.308), width: 16 Scan time: 8.230 The best scores are: opt bits E(85289) NP_000155 (OMIM: 137241) gastric inhibitory polype ( 466) 3188 677.7 1.8e-194 NP_001295347 (OMIM: 137241) gastric inhibitory pol ( 430) 2517 537.1 3.6e-152 XP_011525011 (OMIM: 137241) PREDICTED: gastric inh ( 508) 2145 459.2 1.2e-128 XP_011525012 (OMIM: 137241) PREDICTED: gastric inh ( 508) 2145 459.2 1.2e-128 XP_011525018 (OMIM: 137241) PREDICTED: gastric inh ( 291) 1836 394.3 2.4e-109 XP_011525013 (OMIM: 137241) PREDICTED: gastric inh ( 472) 1474 318.5 2.4e-86 XP_016882076 (OMIM: 137241) PREDICTED: gastric inh ( 302) 1216 264.4 3.2e-70 XP_016879935 (OMIM: 125853,138033) PREDICTED: gluc ( 475) 1191 259.2 1.7e-68 XP_006722340 (OMIM: 125853,138033) PREDICTED: gluc ( 477) 1191 259.2 1.8e-68 NP_000151 (OMIM: 125853,138033) glucagon receptor ( 477) 1191 259.2 1.8e-68 XP_011521841 (OMIM: 125853,138033) PREDICTED: gluc ( 444) 1186 258.2 3.4e-68 XP_016879936 (OMIM: 125853,138033) PREDICTED: gluc ( 355) 1148 250.1 7.1e-66 XP_011525017 (OMIM: 137241) PREDICTED: gastric inh ( 369) 1144 249.3 1.3e-65 XP_011525016 (OMIM: 137241) PREDICTED: gastric inh ( 369) 1144 249.3 1.3e-65 XP_016882075 (OMIM: 137241) PREDICTED: gastric inh ( 303) 1051 229.8 8.2e-60 XP_016882074 (OMIM: 137241) PREDICTED: gastric inh ( 344) 1051 229.8 9.1e-60 XP_016882073 (OMIM: 137241) PREDICTED: gastric inh ( 351) 1051 229.8 9.2e-60 XP_011525015 (OMIM: 137241) PREDICTED: gastric inh ( 425) 1051 229.9 1.1e-59 NP_002053 (OMIM: 138032) glucagon-like peptide 1 r ( 463) 1012 221.7 3.4e-57 XP_016866239 (OMIM: 138032) PREDICTED: glucagon-li ( 468) 1012 221.7 3.4e-57 NP_002971 (OMIM: 182098) secretin receptor precurs ( 440) 984 215.8 1.9e-55 NP_004237 (OMIM: 603659) glucagon-like peptide 2 r ( 553) 984 215.9 2.3e-55 XP_016880828 (OMIM: 603659) PREDICTED: glucagon-li ( 559) 977 214.4 6.4e-55 XP_011522379 (OMIM: 603659) PREDICTED: glucagon-li ( 578) 977 214.4 6.5e-55 XP_011509923 (OMIM: 182098) PREDICTED: secretin re ( 445) 967 212.3 2.2e-54 XP_016860159 (OMIM: 182098) PREDICTED: secretin re ( 435) 961 211.0 5.3e-54 XP_005256918 (OMIM: 603659) PREDICTED: glucagon-li ( 400) 946 207.8 4.3e-53 XP_016880830 (OMIM: 603659) PREDICTED: glucagon-li ( 448) 946 207.9 4.8e-53 XP_016880829 (OMIM: 603659) PREDICTED: glucagon-li ( 483) 946 207.9 5.1e-53 XP_005265494 (OMIM: 192321) PREDICTED: vasoactive ( 456) 933 205.1 3.2e-52 XP_016860161 (OMIM: 182098) PREDICTED: secretin re ( 377) 927 203.8 6.5e-52 NP_001238813 (OMIM: 192321) vasoactive intestinal ( 409) 924 203.2 1.1e-51 NP_001238814 (OMIM: 192321) vasoactive intestinal ( 430) 924 203.2 1.1e-51 NP_004615 (OMIM: 192321) vasoactive intestinal pol ( 457) 924 203.3 1.2e-51 XP_011532381 (OMIM: 192321) PREDICTED: vasoactive ( 416) 920 202.4 2e-51 NP_001238811 (OMIM: 192321) vasoactive intestinal ( 416) 920 202.4 2e-51 XP_005265495 (OMIM: 192321) PREDICTED: vasoactive ( 416) 920 202.4 2e-51 XP_005265496 (OMIM: 192321) PREDICTED: vasoactive ( 410) 915 201.3 4e-51 NP_001186566 (OMIM: 102981) pituitary adenylate cy ( 447) 892 196.5 1.2e-49 XP_016860160 (OMIM: 182098) PREDICTED: secretin re ( 409) 887 195.5 2.3e-49 NP_003373 (OMIM: 601970) vasoactive intestinal pol ( 438) 887 195.5 2.5e-49 XP_005249618 (OMIM: 601970) PREDICTED: vasoactive ( 463) 887 195.5 2.6e-49 XP_006716170 (OMIM: 601970) PREDICTED: vasoactive ( 455) 854 188.6 3.1e-47 XP_005249675 (OMIM: 102981) PREDICTED: pituitary a ( 411) 843 186.3 1.4e-46 NP_001109 (OMIM: 102981) pituitary adenylate cycla ( 468) 843 186.3 1.6e-46 NP_000814 (OMIM: 139191,612781) growth hormone-rel ( 423) 801 177.5 6.4e-44 NP_001295188 (OMIM: 601970) vasoactive intestinal ( 422) 797 176.6 1.1e-43 XP_006716171 (OMIM: 601970) PREDICTED: vasoactive ( 392) 788 174.7 4e-43 XP_011514852 (OMIM: 601970) PREDICTED: vasoactive ( 439) 764 169.7 1.4e-41 XP_016868069 (OMIM: 601970) PREDICTED: vasoactive ( 300) 750 166.7 7.9e-41 >>NP_000155 (OMIM: 137241) gastric inhibitory polypeptid (466 aa) initn: 3188 init1: 3188 opt: 3188 Z-score: 3612.5 bits: 677.7 E(85289): 1.8e-194 Smith-Waterman score: 3188; 100.0% identity (100.0% similar) in 466 aa overlap (1-466:1-466) 10 20 30 40 50 60 pF1KE9 MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 CNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 CNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCEN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 PEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 MLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 LHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 TPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 TEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQ 370 380 390 400 410 420 430 440 450 460 pF1KE9 RQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC :::::::::::::::::::::::::::::::::::::::::::::: NP_000 RQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC 430 440 450 460 >>NP_001295347 (OMIM: 137241) gastric inhibitory polypep (430 aa) initn: 2878 init1: 2517 opt: 2517 Z-score: 2853.0 bits: 537.1 E(85289): 3.6e-152 Smith-Waterman score: 2810; 92.3% identity (92.3% similar) in 466 aa overlap (1-466:1-430) 10 20 30 40 50 60 pF1KE9 MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPS--- 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 CNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCEN ::::::::::::::::::::::::::: NP_001 ---------------------------------VAAGFVLRQCGSDGQWGLWRDHTQCEN 60 70 80 130 140 150 160 170 180 pF1KE9 PEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSF 90 100 110 120 130 140 190 200 210 220 230 240 pF1KE9 MLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVY 150 160 170 180 190 200 250 260 270 280 290 300 pF1KE9 LHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIR 210 220 230 240 250 260 310 320 330 340 350 360 pF1KE9 TPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPV 270 280 290 300 310 320 370 380 390 400 410 420 pF1KE9 TEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQ 330 340 350 360 370 380 430 440 450 460 pF1KE9 RQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC :::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC 390 400 410 420 430 >>XP_011525011 (OMIM: 137241) PREDICTED: gastric inhibit (508 aa) initn: 2171 init1: 2145 opt: 2145 Z-score: 2430.6 bits: 459.2 E(85289): 1.2e-128 Smith-Waterman score: 3028; 91.6% identity (91.6% similar) in 498 aa overlap (1-456:1-498) 10 20 30 40 50 60 pF1KE9 MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 CNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCEN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 PEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 MLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 LHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIR 250 260 270 280 290 300 310 pF1KE9 TPILMTIL------------------------------------------INFLIFIRIL :::::::: :::::::::: XP_011 TPILMTILVGSVPPPPGRPQGFPILGSGLPPPPAPSEWDRGWLSPYLSPQINFLIFIRIL 310 320 330 340 350 360 320 330 340 350 360 370 pF1KE9 GILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEI 370 380 390 400 410 420 380 390 400 410 420 430 pF1KE9 FLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPG 430 440 450 460 470 480 440 450 460 pF1KE9 EVPTSRGLSSGTLPGPGNEASRELESYC :::::::::::::::::: XP_011 EVPTSRGLSSGTLPGPGNEASRELESYC 490 500 >>XP_011525012 (OMIM: 137241) PREDICTED: gastric inhibit (508 aa) initn: 2171 init1: 2145 opt: 2145 Z-score: 2430.6 bits: 459.2 E(85289): 1.2e-128 Smith-Waterman score: 3028; 91.6% identity (91.6% similar) in 498 aa overlap (1-456:1-498) 10 20 30 40 50 60 pF1KE9 MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 CNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCEN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 PEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 MLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 LHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIR 250 260 270 280 290 300 310 pF1KE9 TPILMTIL------------------------------------------INFLIFIRIL :::::::: :::::::::: XP_011 TPILMTILVGSVPPPPGRPQGFPILGSGLPPPPAPSEWDRGWLSPYLSPQINFLIFIRIL 310 320 330 340 350 360 320 330 340 350 360 370 pF1KE9 GILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEI 370 380 390 400 410 420 380 390 400 410 420 430 pF1KE9 FLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPG 430 440 450 460 470 480 440 450 460 pF1KE9 EVPTSRGLSSGTLPGPGNEASRELESYC :::::::::::::::::: XP_011 EVPTSRGLSSGTLPGPGNEASRELESYC 490 500 >>XP_011525018 (OMIM: 137241) PREDICTED: gastric inhibit (291 aa) initn: 1836 init1: 1836 opt: 1836 Z-score: 2084.2 bits: 394.3 E(85289): 2.4e-109 Smith-Waterman score: 1836; 100.0% identity (100.0% similar) in 265 aa overlap (1-265:1-265) 10 20 30 40 50 60 pF1KE9 MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 CNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCEN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 PEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 MLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 LHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIR ::::::::::::::::::::::::: XP_011 LHSLLVLVGGSEEGHFRYYLLLGWGTCTRTRSAGSATKSRPFGGLYGPPSS 250 260 270 280 290 >>XP_011525013 (OMIM: 137241) PREDICTED: gastric inhibit (472 aa) initn: 1861 init1: 1474 opt: 1474 Z-score: 1671.1 bits: 318.5 E(85289): 2.4e-86 Smith-Waterman score: 2650; 84.3% identity (84.3% similar) in 498 aa overlap (1-456:1-462) 10 20 30 40 50 60 pF1KE9 MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPS--- 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 CNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCEN ::::::::::::::::::::::::::: XP_011 ---------------------------------VAAGFVLRQCGSDGQWGLWRDHTQCEN 60 70 80 130 140 150 160 170 180 pF1KE9 PEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSF 90 100 110 120 130 140 190 200 210 220 230 240 pF1KE9 MLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVY 150 160 170 180 190 200 250 260 270 280 290 300 pF1KE9 LHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIR 210 220 230 240 250 260 310 pF1KE9 TPILMTIL------------------------------------------INFLIFIRIL :::::::: :::::::::: XP_011 TPILMTILVGSVPPPPGRPQGFPILGSGLPPPPAPSEWDRGWLSPYLSPQINFLIFIRIL 270 280 290 300 310 320 320 330 340 350 360 370 pF1KE9 GILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEI 330 340 350 360 370 380 380 390 400 410 420 430 pF1KE9 FLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPG 390 400 410 420 430 440 440 450 460 pF1KE9 EVPTSRGLSSGTLPGPGNEASRELESYC :::::::::::::::::: XP_011 EVPTSRGLSSGTLPGPGNEASRELESYC 450 460 470 >>XP_016882076 (OMIM: 137241) PREDICTED: gastric inhibit (302 aa) initn: 1216 init1: 1216 opt: 1216 Z-score: 1381.7 bits: 264.4 E(85289): 3.2e-70 Smith-Waterman score: 1216; 100.0% identity (100.0% similar) in 181 aa overlap (286-466:122-302) 260 270 280 290 300 310 pF1KE9 FRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFI :::::::::::::::::::::::::::::: XP_016 GGGRLPAQSPGARGRLRGGPLPLLPAPRLGCWERNEVKAIWWIIRTPILMTILINFLIFI 100 110 120 130 140 150 320 330 340 350 360 370 pF1KE9 RILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLG 160 170 180 190 200 210 380 390 400 410 420 430 pF1KE9 FEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGS 220 230 240 250 260 270 440 450 460 pF1KE9 GPGEVPTSRGLSSGTLPGPGNEASRELESYC ::::::::::::::::::::::::::::::: XP_016 GPGEVPTSRGLSSGTLPGPGNEASRELESYC 280 290 300 >>XP_016879935 (OMIM: 125853,138033) PREDICTED: glucagon (475 aa) initn: 1412 init1: 894 opt: 1191 Z-score: 1350.5 bits: 259.2 E(85289): 1.7e-68 Smith-Waterman score: 1489; 51.0% identity (74.2% similar) in 453 aa overlap (18-459:13-457) 10 20 30 40 50 60 pF1KE9 MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLA ::: : ..:. :...:. : .:...:. ::. :. XP_016 MPPCQPQRPLLLLLLLLACQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELV 10 20 30 40 50 70 80 90 100 110 pF1KE9 CNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQW-----GL-WRD :: .:: : :: . :.:: ::::::::::.: ::...:: :::: : ::: XP_016 CNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRD 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 HTQCE-NPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIH .::. . :. :. . . .::::::::::::..::::: ::. . .:::::: :: XP_016 ASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIH 120 130 140 150 160 170 180 190 200 210 220 pF1KE9 INLFTSFMLRAAAILSRDRLL-PRPGPYLGDQ-ALALW--NQALAACRTAQIVTQYCVGA :::.::.:.:...: : :: : . .::. ... : . :.:.::.: . :: . : XP_016 ANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVA 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE9 NYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWER :: ::::::.:::.:: :. :.. : :: .::::: :::.::..:. :.::.::: XP_016 NYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTS 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE9 NEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPL :. ..:::.: :....:::::.::.::. .:..:::.:::. ::..:::.:::::.:: XP_016 NDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPL 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE9 LGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHH ::::::::: ::.:.:.:.:: ::: :..:::::::.::.:::::.:::::::.:: ::. XP_016 LGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHR 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE9 CRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC :: . : ::. .:: .:.::. : :. :. : : :.. : XP_016 WRLGKVLWEERNTSNHRA------SSSPGHGPPSKELQFGR--GGGSQDSSAETPLAGGL 420 430 440 450 460 XP_016 PRLAESPF 470 >>XP_006722340 (OMIM: 125853,138033) PREDICTED: glucagon (477 aa) initn: 1437 init1: 894 opt: 1191 Z-score: 1350.5 bits: 259.2 E(85289): 1.8e-68 Smith-Waterman score: 1491; 50.4% identity (73.2% similar) in 466 aa overlap (5-459:9-459) 10 20 30 40 50 pF1KE9 MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPP :.: ::: :. : . : :. :...:. : .:...:. :: XP_006 MPPCQPQRPLLLLLLLLA-CQPQVPSA------QVMDFLFEKWKLYGDQCHHNLSLLPPP 10 20 30 40 50 60 70 80 90 100 110 pF1KE9 SGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQW-----GL . :.:: .:: : :: . :.:: ::::::::::.: ::...:: :::: : XP_006 TELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQ 60 70 80 90 100 110 120 130 140 150 160 pF1KE9 -WRDHTQCE-NPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTR ::: .::. . :. :. . . .::::::::::::..::::: ::. . .::::: XP_006 PWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTR 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE9 NYIHINLFTSFMLRAAAILSRDRLL-PRPGPYLGDQ-ALALW--NQALAACRTAQIVTQY : :: :::.::.:.:...: : :: : . .::. ... : . :.:.::.: . :: XP_006 NAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQY 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE9 CVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQ . ::: ::::::.:::.:: :. :.. : :: .::::: :::.::..:. :.::.: XP_006 GIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQ 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE9 CWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLT :: :. ..:::.: :....:::::.::.::. .:..:::.:::. ::..:::.:::: XP_006 CWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLT 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE9 LVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRR :.::::::::::: ::.:.:.:.:: ::: :..:::::::.::.:::::.:::::::.:: XP_006 LIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRR 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE9 GWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESY ::. :: . : ::. .:: .:.::. : :. :. : : :.. : XP_006 RWHRWRLGKVLWEERNTSNHRA------SSSPGHGPPSKELQFGR--GGGSQDSSAETPL 420 430 440 450 460 pF1KE9 C XP_006 AGGLPRLAESPF 470 >>NP_000151 (OMIM: 125853,138033) glucagon receptor prec (477 aa) initn: 1437 init1: 894 opt: 1191 Z-score: 1350.5 bits: 259.2 E(85289): 1.8e-68 Smith-Waterman score: 1491; 50.4% identity (73.2% similar) in 466 aa overlap (5-459:9-459) 10 20 30 40 50 pF1KE9 MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPP :.: ::: :. : . : :. :...:. : .:...:. :: NP_000 MPPCQPQRPLLLLLLLLA-CQPQVPSA------QVMDFLFEKWKLYGDQCHHNLSLLPPP 10 20 30 40 50 60 70 80 90 100 110 pF1KE9 SGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQW-----GL . :.:: .:: : :: . :.:: ::::::::::.: ::...:: :::: : NP_000 TELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQ 60 70 80 90 100 110 120 130 140 150 160 pF1KE9 -WRDHTQCE-NPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTR ::: .::. . :. :. . . .::::::::::::..::::: ::. . .::::: NP_000 PWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTR 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE9 NYIHINLFTSFMLRAAAILSRDRLL-PRPGPYLGDQ-ALALW--NQALAACRTAQIVTQY : :: :::.::.:.:...: : :: : . .::. ... : . :.:.::.: . :: NP_000 NAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQY 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE9 CVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQ . ::: ::::::.:::.:: :. :.. : :: .::::: :::.::..:. :.::.: NP_000 GIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQ 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE9 CWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLT :: :. ..:::.: :....:::::.::.::. .:..:::.:::. ::..:::.:::: NP_000 CWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLT 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE9 LVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRR :.::::::::::: ::.:.:.:.:: ::: :..:::::::.::.:::::.:::::::.:: NP_000 LIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRR 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE9 GWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESY ::. :: . : ::. .:: .:.::. : :. :. : : :.. : NP_000 RWHRWRLGKVLWEERNTSNHRA------SSSPGHGPPSKELQFGR--GGGSQDSSAETPL 420 430 440 450 460 pF1KE9 C NP_000 AGGLPRLAESPF 470 466 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 17:59:10 2016 done: Mon Nov 7 17:59:11 2016 Total Scan time: 8.230 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]