FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7933, 367 aa 1>>>pF1KB7933 367 - 367 aa - 367 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.0365+/-0.000379; mu= -10.0039+/- 0.024 mean_var=523.2271+/-107.186, 0's: 0 Z-trim(126.6): 76 B-trim: 0 in 0/62 Lambda= 0.056070 statistics sampled from 52809 (52920) to 52809 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.851), E-opt: 0.2 (0.62), width: 16 Scan time: 11.700 The best scores are: opt bits E(85289) NP_006159 (OMIM: 602563) homeobox protein Nkx-6.1 ( 367) 2428 210.0 6.9e-54 NP_796374 (OMIM: 605955) homeobox protein Nkx-6.2 ( 277) 969 91.9 1.9e-18 XP_016872278 (OMIM: 605955) PREDICTED: homeobox pr ( 277) 964 91.5 2.5e-18 XP_016868632 (OMIM: 610772) PREDICTED: homeobox pr ( 265) 595 61.6 2.4e-09 NP_066305 (OMIM: 604640) T-cell leukemia homeobox ( 291) 348 41.7 0.0026 NP_057254 (OMIM: 604240) T-cell leukemia homeobox ( 284) 326 39.9 0.0088 >>NP_006159 (OMIM: 602563) homeobox protein Nkx-6.1 [Hom (367 aa) initn: 2428 init1: 2428 opt: 2428 Z-score: 1088.5 bits: 210.0 E(85289): 6.9e-54 Smith-Waterman score: 2428; 100.0% identity (100.0% similar) in 367 aa overlap (1-367:1-367) 10 20 30 40 50 60 pF1KB7 MLAVGAMEGTRQSAFLLSSPPLAALHSMAEMKTPLYPAAYPPLPAGPPSSSSSSSSSSSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MLAVGAMEGTRQSAFLLSSPPLAALHSMAEMKTPLYPAAYPPLPAGPPSSSSSSSSSSSP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 SPPLGTHNPGGLKPPATGGLSSLGSPPQQLSAATPHGINDILSRPSMPVASGAALPSASP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SPPLGTHNPGGLKPPATGGLSSLGSPPQQLSAATPHGINDILSRPSMPVASGAALPSASP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 SGSSSSSSSSASASSASAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPPPPGLYFSPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SGSSSSSSSSASASSASAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPPPPGLYFSPS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 AAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQGSILLDKDGKRKHTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 AAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQGSILLDKDGKRKHTR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 PTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 PTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 TAKKKQDSETERLKGASENEEEDDDYNKPLDPNSDDEKITQLLKKHKSSSGGGGGLLLHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 TAKKKQDSETERLKGASENEEEDDDYNKPLDPNSDDEKITQLLKKHKSSSGGGGGLLLHA 310 320 330 340 350 360 pF1KB7 SEPESSS ::::::: NP_006 SEPESSS >>NP_796374 (OMIM: 605955) homeobox protein Nkx-6.2 [Hom (277 aa) initn: 1064 init1: 699 opt: 969 Z-score: 452.1 bits: 91.9 E(85289): 1.9e-18 Smith-Waterman score: 1075; 55.3% identity (67.4% similar) in 356 aa overlap (7-355:1-274) 10 20 30 40 50 60 pF1KB7 MLAVGAMEGTRQSAFLLSSPPLAALHSMAEMKTPLYPAAYPPLPAGPPSSSSSSSSSSSP :. .: .::.::: ::::::.:::::: :.: : NP_796 MDTNRPGAFVLSSAPLAALHNMAEMKTSLFPYAL-------------------- 10 20 30 70 80 90 100 110 120 pF1KB7 SPPLGTHNPGGLKPPATGGLSSLGSPPQQLSAATPHGINDILSRPSMPVASGAALPSASP ..:.:.: :: :::.. :: .:::::.:::.:: ::: NP_796 ------QGPAGFKAPALGGLGA------QLPLGTPHGISDILGRPV-----GAA------ 40 50 60 70 130 140 150 160 170 180 pF1KB7 SGSSSSSSSSASASSASAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPPPPGLYFSPS :. :::.::::...:. :.::.: NP_796 -GG-------------------------------GLLGGLPRLNGLASSA---GVYFGP- 80 90 190 200 210 220 230 240 pF1KB7 AAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQGSILLDKDGKRKHTR ::::: : ::::::::::: :::::::.:. :::: ::: :..: :::::.::.: NP_796 AAAVAR-G-YPKPLAELPGRPPIFWPGVVQGAPWRDPRLAGPAPAGGVL-DKDGKKKHSR 100 110 120 130 140 150 250 260 270 280 290 300 pF1KB7 PTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMA :::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::: NP_796 PTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKRHAAEMA 160 170 180 190 200 210 310 320 330 340 350 pF1KB7 TAKKKQDSETERLKGASENEEEDDDYNKPLDPNSDDEKITQLLKKHKSSS-------GGG .:::::::..:.:: .. . :.::.::.::::::::::::.:::::: :. ::: NP_796 SAKKKQDSDAEKLKVGGSDAEDDDEYNRPLDPNSDDEKITRLLKKHKPSNLALVSPCGGG 220 230 240 250 260 270 360 pF1KB7 GGLLLHASEPESSS .: NP_796 AGDAL >>XP_016872278 (OMIM: 605955) PREDICTED: homeobox protei (277 aa) initn: 1059 init1: 694 opt: 964 Z-score: 449.9 bits: 91.5 E(85289): 2.5e-18 Smith-Waterman score: 1070; 55.1% identity (67.4% similar) in 356 aa overlap (7-355:1-274) 10 20 30 40 50 60 pF1KB7 MLAVGAMEGTRQSAFLLSSPPLAALHSMAEMKTPLYPAAYPPLPAGPPSSSSSSSSSSSP :. .: .::.::: ::::::.:::::: :.: : XP_016 MDTNRPGAFVLSSAPLAALHNMAEMKTSLFPYAL-------------------- 10 20 30 70 80 90 100 110 120 pF1KB7 SPPLGTHNPGGLKPPATGGLSSLGSPPQQLSAATPHGINDILSRPSMPVASGAALPSASP ..:.:.: :: :::.. :: .:::::.:::.:: ::: XP_016 ------QGPAGFKAPALGGLGA------QLPLGTPHGISDILGRPV-----GAA------ 40 50 60 70 130 140 150 160 170 180 pF1KB7 SGSSSSSSSSASASSASAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPPPPGLYFSPS :. :::.::::...:. :.::.: XP_016 -GG-------------------------------GLLGGLPRLNGLASSA---GVYFGP- 80 90 190 200 210 220 230 240 pF1KB7 AAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQGSILLDKDGKRKHTR ::::: : ::::::::::: :::::::.:. :::: ::: :..: :::::.::.: XP_016 AAAVAR-G-YPKPLAELPGRPPIFWPGVVQGAPWRDPRLAGPAPAGGVL-DKDGKKKHSR 100 110 120 130 140 150 250 260 270 280 290 300 pF1KB7 PTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMA :::::::::::::::::::::::::::::::::::::::::::::::::::::.::.::: XP_016 PTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKRHAVEMA 160 170 180 190 200 210 310 320 330 340 350 pF1KB7 TAKKKQDSETERLKGASENEEEDDDYNKPLDPNSDDEKITQLLKKHKSSS-------GGG .:::::::..:.:: .. . :.::.::.::::::::::::.:::::: :. ::: XP_016 SAKKKQDSDAEKLKVGGSDAEDDDEYNRPLDPNSDDEKITRLLKKHKPSNLALVSPCGGG 220 230 240 250 260 270 360 pF1KB7 GGLLLHASEPESSS .: XP_016 AGDAL >>XP_016868632 (OMIM: 610772) PREDICTED: homeobox protei (265 aa) initn: 653 init1: 390 opt: 595 Z-score: 288.9 bits: 61.6 E(85289): 2.4e-09 Smith-Waterman score: 634; 41.7% identity (57.5% similar) in 348 aa overlap (7-349:1-254) 10 20 30 40 50 60 pF1KB7 MLAVGAMEGTRQSAFLLSSPPLAALHSMAEMKTPLYPAAYPPLPAGPPSSSSSSSSSSSP ::.. :..:::.. ::: .. :::.:. . : ..: . XP_016 MESNLQGTFLLNNTPLA---QFPEMKAPV-------------CQYSVQNSFYKL 10 20 30 70 80 90 100 110 120 pF1KB7 SPPLGTHNPGGLKPPATGGLSSLGSPPQQLSAATPHGINDILSRPSMPVASGAALPSASP ::: :: : ::.:.:::::.:::::: :.: XP_016 SPP-------GLGP--------------QLAAGTPHGITDILSRPV-----------AAP 40 50 60 130 140 150 160 170 pF1KB7 SGSSSSSSSSASASSASAAAAAAAAAAAAASSPAGLLAGLPR---FSSLSPPPPPPGLYF ..: ::.: :. :..:: :.:. XP_016 NNS--------------------------------LLSGYPHVAGFGGLS----SQGVYY 70 80 90 180 190 200 210 220 230 pF1KB7 SPSAAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQGSILLDKDGKRK ::. :: . : : : :: : . :. :: .: :. . . : :. :.: XP_016 SPQ------VGNFSKAGNEYPTRTRNCWADTGQD--WRGGR-QCS-NTPDPLSDSIHKKK 100 110 120 130 140 240 250 260 270 280 290 pF1KB7 HTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAA ::::::.:.:::::::::::::::::::::::::::::::::::::::::::::::: : XP_016 HTRPTFTGHQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKSAL 150 160 170 180 190 200 300 310 320 330 340 350 pF1KB7 EMATAKKKQDSETERLKGASE--NEEEDDDYNKPLDPNSDDEKITQLLKKHKSSSGGGGG : ... . . . :... .:.:::.:::::::.:::::: ::.::... XP_016 EPSSSTPRAPGGAGAGAGGDRAPSENEDDEYNKPLDPDSDDEKIRLLLRKHRAAFSVLSL 210 220 230 240 250 260 360 pF1KB7 LLLHASEPESSS XP_016 GAHSV >>NP_066305 (OMIM: 604640) T-cell leukemia homeobox prot (291 aa) initn: 376 init1: 254 opt: 348 Z-score: 180.4 bits: 41.7 E(85289): 0.0026 Smith-Waterman score: 358; 34.2% identity (56.7% similar) in 263 aa overlap (91-333:6-259) 70 80 90 100 110 pF1KB7 SPPLGTHNPGGLKPPATGGLSSLGSPPQQLSAATPH-------GINDILSRP---SMPVA :: ::: ::..::. : : :. NP_066 MEAPASAQTPHPHEPISFGIDQILNSPDQDSAPAP 10 20 30 120 130 140 150 160 pF1KB7 ---SGAALPSASPSGSSSSSSSSASASSASAAAAAAAAAAAAAS---SPAGLLAGLPRFS .::. .. :.: ... : :: :. .: :.. ... .:::.. .: NP_066 RGPDGASYLGGPPGGRPGATYPSLPASFAGLGAPFEDAGSYSVNLSLAPAGVIR-VPAHR 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB7 SLS---PPPPPPGLYFSPSAAAVAAVGRYPKPLAELPGR-TPIFWPGVMQSPPWRDARLA : ::: : .: ::. .:...: : : : . . .. :. .: NP_066 PLPGAVPPPLPSALPAMPSVPTVSSLGGLNFPWMESSRRFVKDRFTAAAALTPFTVTRRI 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB7 CTPHQGSILLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQV :.:. :::. : .:: :: ::: :.. ::::. ::: :: :: ::..:: NP_066 GHPYQNRT----PPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTDAQV 160 170 180 190 200 210 290 300 310 320 330 340 pF1KB7 KVWFQNRRTKWRKKHAAEMATAKKKQDSETERLKGASENEEEDDDYNKPLDPNSDDEKIT :.::::::::::.. .:: :...: : :: ... . . : ..:. NP_066 KTWFQNRRTKWRRQ-TAEEREAERQQAS---RLMLQLQHDAFQKSLNDSIQPDPLCLHNS 220 230 240 250 260 350 360 pF1KB7 QLLKKHKSSSGGGGGLLLHASEPESSS NP_066 SLFALQNLQPWEEDSSKVPAVTSLV 270 280 290 >>NP_057254 (OMIM: 604240) T-cell leukemia homeobox prot (284 aa) initn: 339 init1: 247 opt: 326 Z-score: 170.9 bits: 39.9 E(85289): 0.0088 Smith-Waterman score: 326; 32.8% identity (58.6% similar) in 256 aa overlap (87-332:8-245) 60 70 80 90 100 110 pF1KB7 SSSPSPPLGTHNPGGLKPPATGGLSSLGSPPQQLSAATP--HGINDILSRPSMPVASGAA :..: : ::..::: : : ..: . NP_057 MEPGMLGPHNLPHHEPISFGIDQILSGPETP-GGGLG 10 20 30 120 130 140 150 160 170 pF1KB7 LPSASPSGSSSSSSSSASASSASAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPPPPG : .. .: . ... :.. .::. . :.. : .:: .: .:. : . : : :: NP_057 LGRGG-QGHGENGAFSGGYHGASGYGPAGSLAPLPGSSGVGP-GGVIRVPAHRPLPVPP- 40 50 60 70 80 90 180 190 200 210 220 230 pF1KB7 LYFSPSAAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARL--ACTPHQGSILLDK :...: :. : :. :. : . . .: . .. . :: : .: .:. . . NP_057 ----PAGGAPAVPG--PSGLGGAGGLAGLTFPWMDSGRRFAKDRLTAALSPFSGTRRIGH 100 110 120 130 140 240 250 260 270 280 pF1KB7 D------GKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQN :::. : .:: .:.. ::. : . ::::. ::: :: .: ::..:::.:::: NP_057 PYQNRTPPKRKKPRTSFSRSQVLELERRFLRQKYLASAERAALAKALRMTDAQVKTWFQN 150 160 170 180 190 200 290 300 310 320 330 340 pF1KB7 RRTKWRKKHAAEMATAKKKQDSETERLKGASENEEEDDDYNKPLDPNSDDEKITQLLKKH ::::::.. : : ...: .: : . ..: .:: : NP_057 RRTKWRRQTAEE-------REAERHR-AGRLLLHLQQDALPRPLRPPLPPDPLCLHNSSL 210 220 230 240 250 350 360 pF1KB7 KSSSGGGGGLLLHASEPESSS NP_057 FALQNLQPWAEDNKVASVSGLASVV 260 270 280 367 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 17:50:13 2016 done: Mon Nov 7 17:50:15 2016 Total Scan time: 11.700 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]