FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3306, 770 aa 1>>>pF1KE3306 770 - 770 aa - 770 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 17.0614+/-0.000661; mu= -32.6653+/- 0.041 mean_var=1054.9614+/-223.506, 0's: 0 Z-trim(122.3): 700 B-trim: 2149 in 1/58 Lambda= 0.039487 statistics sampled from 39436 (40321) to 39436 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.749), E-opt: 0.2 (0.473), width: 16 Scan time: 11.750 The best scores are: opt bits E(85289) NP_277071 (OMIM: 116951) cyclin-dependent kinase 1 ( 770) 5048 304.1 1.5e-81 NP_001278274 (OMIM: 176873) cyclin-dependent kinas ( 772) 5038 303.5 2.2e-81 NP_076916 (OMIM: 116951) cyclin-dependent kinase 1 ( 780) 4376 265.8 5e-70 NP_277021 (OMIM: 176873) cyclin-dependent kinase 1 ( 782) 4374 265.7 5.4e-70 NP_277024 (OMIM: 176873) cyclin-dependent kinase 1 ( 748) 4365 265.1 7.5e-70 XP_016858415 (OMIM: 176873) PREDICTED: cyclin-depe ( 781) 4162 253.6 2.3e-66 XP_016858414 (OMIM: 176873) PREDICTED: cyclin-depe ( 791) 4152 253.0 3.5e-66 NP_001300911 (OMIM: 116951) cyclin-dependent kinas ( 779) 4137 252.2 6.3e-66 NP_277025 (OMIM: 176873) cyclin-dependent kinase 1 ( 565) 3706 227.5 1.2e-58 NP_001778 (OMIM: 176873) cyclin-dependent kinase 1 ( 795) 3657 224.8 1.1e-57 XP_016858417 (OMIM: 176873) PREDICTED: cyclin-depe ( 761) 3654 224.6 1.2e-57 XP_006711128 (OMIM: 176873) PREDICTED: cyclin-depe ( 785) 3650 224.4 1.4e-57 XP_016858416 (OMIM: 176873) PREDICTED: cyclin-depe ( 770) 3647 224.3 1.6e-57 XP_011540796 (OMIM: 176873) PREDICTED: cyclin-depe ( 770) 3647 224.3 1.6e-57 XP_011540793 (OMIM: 176873) PREDICTED: cyclin-depe ( 804) 3647 224.3 1.6e-57 XP_011540794 (OMIM: 176873) PREDICTED: cyclin-depe ( 804) 3647 224.3 1.6e-57 XP_011540792 (OMIM: 176873) PREDICTED: cyclin-depe ( 804) 3647 224.3 1.6e-57 XP_011540795 (OMIM: 176873) PREDICTED: cyclin-depe ( 794) 3646 224.2 1.7e-57 XP_011540797 (OMIM: 176873) PREDICTED: cyclin-depe ( 760) 3643 224.0 1.8e-57 NP_001300825 (OMIM: 116951) cyclin-dependent kinas ( 783) 3633 223.5 2.8e-57 XP_011540798 (OMIM: 176873) PREDICTED: cyclin-depe ( 578) 3454 213.1 2.6e-54 NP_277022 (OMIM: 176873) cyclin-dependent kinase 1 ( 526) 3426 211.5 7.5e-54 NP_443714 (OMIM: 603464) cyclin-dependent kinase 1 ( 360) 1224 85.9 3.4e-16 XP_006721371 (OMIM: 603464) PREDICTED: cyclin-depe ( 354) 1177 83.2 2.1e-15 XP_006721373 (OMIM: 603464) PREDICTED: cyclin-depe ( 343) 1167 82.6 3.1e-15 XP_016879296 (OMIM: 603464) PREDICTED: cyclin-depe ( 337) 1128 80.4 1.4e-14 NP_001153839 (OMIM: 603464) cyclin-dependent kinas ( 289) 1031 74.8 5.9e-13 XP_016879297 (OMIM: 603464) PREDICTED: cyclin-depe ( 289) 1031 74.8 5.9e-13 NP_001092003 (OMIM: 603464) cyclin-dependent kinas ( 283) 984 72.1 3.7e-12 XP_016879298 (OMIM: 603464) PREDICTED: cyclin-depe ( 283) 984 72.1 3.7e-12 NP_443713 (OMIM: 603464) cyclin-dependent kinase 1 ( 272) 974 71.5 5.4e-12 XP_016879299 (OMIM: 603464) PREDICTED: cyclin-depe ( 272) 974 71.5 5.4e-12 NP_001249 (OMIM: 123828) cyclin-dependent kinase 3 ( 305) 912 68.0 6.7e-11 NP_001789 (OMIM: 116953) cyclin-dependent kinase 2 ( 298) 905 67.6 8.7e-11 NP_001777 (OMIM: 116940) cyclin-dependent kinase 1 ( 297) 834 63.6 1.4e-09 NP_001307847 (OMIM: 116940) cyclin-dependent kinas ( 297) 834 63.6 1.4e-09 XP_005270360 (OMIM: 116940) PREDICTED: cyclin-depe ( 297) 834 63.6 1.4e-09 NP_001790 (OMIM: 601955) cyclin-dependent kinase 7 ( 346) 827 63.2 2.1e-09 XP_011521719 (OMIM: 603464) PREDICTED: cyclin-depe ( 261) 812 62.2 3.1e-09 NP_001034892 (OMIM: 610076) cyclin-dependent kinas ( 346) 814 62.5 3.5e-09 NP_004926 (OMIM: 123831,616342) cyclin-dependent-l ( 292) 809 62.1 3.8e-09 XP_011521710 (OMIM: 603464) PREDICTED: cyclin-depe ( 369) 812 62.4 4e-09 XP_011521709 (OMIM: 603464) PREDICTED: cyclin-depe ( 375) 812 62.4 4e-09 XP_011521708 (OMIM: 603464) PREDICTED: cyclin-depe ( 386) 812 62.4 4.1e-09 XP_011521707 (OMIM: 603464) PREDICTED: cyclin-depe ( 392) 812 62.4 4.1e-09 NP_002586 (OMIM: 603440) cyclin-dependent kinase 1 ( 523) 808 62.3 5.9e-09 XP_016874894 (OMIM: 603440) PREDICTED: cyclin-depe ( 523) 808 62.3 5.9e-09 XP_016874895 (OMIM: 603440) PREDICTED: cyclin-depe ( 523) 808 62.3 5.9e-09 NP_001163935 (OMIM: 603440) cyclin-dependent kinas ( 523) 804 62.1 6.9e-09 XP_016870050 (OMIM: 610076) PREDICTED: cyclin-depe ( 351) 794 61.4 7.8e-09 >>NP_277071 (OMIM: 116951) cyclin-dependent kinase 11A i (770 aa) initn: 5048 init1: 5048 opt: 5048 Z-score: 1585.2 bits: 304.1 E(85289): 1.5e-81 Smith-Waterman score: 5048; 99.2% identity (99.6% similar) in 770 aa overlap (1-770:1-770) 10 20 30 40 50 60 pF1KE3 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::: NP_277 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 RRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 RRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 ERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 ERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 EEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSRESE :::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::: NP_277 EEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 EAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 EAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 EGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 EGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 GSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 GSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 SNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVG ::::::::::::::::::::::::::::::::::: :::::::::::::::::::::::: NP_277 SNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 CIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLR :::::::::::::::.:::::::::::.::::::::::::::::.::::::::::::::: NP_277 CIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLR 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 KRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 KRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQ 670 680 690 700 710 720 730 740 750 760 770 pF1KE3 RVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF :::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 RVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 730 740 750 760 770 >>NP_001278274 (OMIM: 176873) cyclin-dependent kinase 11 (772 aa) initn: 4327 init1: 4327 opt: 5038 Z-score: 1582.1 bits: 303.5 E(85289): 2.2e-81 Smith-Waterman score: 5038; 99.2% identity (99.4% similar) in 772 aa overlap (1-770:1-772) 10 20 30 40 50 60 pF1KE3 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKE--RE ::::::::::::::::::::::::::::::::::::.::::::::::: ::::::: :: NP_001 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRKHARVKEKERE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 HERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQRE 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE3 QKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 EEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: : NP_001 EEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGE 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE3 SEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNR :::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::: NP_001 SEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNR 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE3 IEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREI 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE3 VVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDL 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE3 KTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWS 550 560 570 580 590 600 600 610 620 630 640 650 pF1KE3 VGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNN 610 620 630 640 650 660 660 670 680 690 700 710 pF1KE3 LRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSE 670 680 690 700 710 720 720 730 740 750 760 770 pF1KE3 QQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 730 740 750 760 770 >>NP_076916 (OMIM: 116951) cyclin-dependent kinase 11A i (780 aa) initn: 4330 init1: 4330 opt: 4376 Z-score: 1378.2 bits: 265.8 E(85289): 5e-70 Smith-Waterman score: 5000; 97.8% identity (98.2% similar) in 780 aa overlap (1-770:1-780) 10 20 30 40 50 60 pF1KE3 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::: NP_076 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK----------WK :::::::::::::::::::::::::::::::::::::::::::::::: : NP_076 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGK 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 HARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 HARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMR 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE3 EQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 EQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRER 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 FELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 FELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPES 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE3 RFDRDSRESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSV :::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 RFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSV 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE3 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE3 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE3 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEY ::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::: NP_076 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEY 550 560 570 580 590 600 600 610 620 630 640 650 pF1KE3 STAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMT :::::::::::::::::::::::::.:::::::::::.::::::::::::::::.::::: NP_076 STAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMT 610 620 630 640 650 660 660 670 680 690 700 710 pF1KE3 FSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 FSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMF 670 680 690 700 710 720 720 730 740 750 760 770 pF1KE3 PTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 PTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 730 740 750 760 770 780 >>NP_277021 (OMIM: 176873) cyclin-dependent kinase 11B i (782 aa) initn: 4346 init1: 4346 opt: 4374 Z-score: 1377.6 bits: 265.7 E(85289): 5.4e-70 Smith-Waterman score: 5008; 98.0% identity (98.1% similar) in 782 aa overlap (1-770:1-782) 10 20 30 40 50 60 pF1KE3 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKW----------K ::::::::::::::::::::::::::::::::::::.::::::::::: : NP_277 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK 70 80 90 100 110 120 120 130 140 150 160 pF1KE3 HARVKE--REHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK :::::: :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE3 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE3 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE3 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE3 ESRFDRDSRESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCR :::::::: ::::::::::::::::::::::::::::::: ::::::::::::::::::: NP_277 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCR 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE3 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE3 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 490 500 510 520 530 540 530 540 550 560 570 580 pF1KE3 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 550 560 570 580 590 600 590 600 610 620 630 640 pF1KE3 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 610 620 630 640 650 660 650 660 670 680 690 700 pF1KE3 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS 670 680 690 700 710 720 710 720 730 740 750 760 pF1KE3 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL 730 740 750 760 770 780 770 pF1KE3 KF :: NP_277 KF >>NP_277024 (OMIM: 176873) cyclin-dependent kinase 11B i (748 aa) initn: 4346 init1: 4346 opt: 4365 Z-score: 1375.0 bits: 265.1 E(85289): 7.5e-70 Smith-Waterman score: 4774; 97.5% identity (98.0% similar) in 748 aa overlap (35-770:1-748) 10 20 30 40 50 60 pF1KE3 KDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRN ...::::::::::::::::::::::::::: NP_277 MSQSDDRDSKRDSLEEGELRDHRMEITIRN 10 20 30 70 80 90 100 110 pF1KE3 SPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKW----------KHARV ::::::::::::::::::::::::::::::::.::::::::::: ::::: NP_277 SPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGKHARV 40 50 60 70 80 90 120 130 140 150 160 170 pF1KE3 KE--REHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQ :: :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 KEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQ 100 110 120 130 140 150 180 190 200 210 220 230 pF1KE3 QKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 QKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFE 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE3 LGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 LGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEG 220 230 240 250 260 270 300 310 320 330 340 350 pF1KE3 STSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 STSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRF 280 290 300 310 320 330 360 370 380 390 400 410 pF1KE3 DRDSRESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEE :::: ::::::::::::::::::::::::::::::: ::::::::::::::::::::::: NP_277 DRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEE 340 350 360 370 380 390 420 430 440 450 460 470 pF1KE3 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNI 400 410 420 430 440 450 480 490 500 510 520 530 pF1KE3 VTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 VTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNW 460 470 480 490 500 510 540 550 560 570 580 590 pF1KE3 ILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 ILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYST 520 530 540 550 560 570 600 610 620 630 640 650 pF1KE3 AVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 AVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFS 580 590 600 610 620 630 660 670 680 690 700 710 pF1KE3 EHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 EHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPT 640 650 660 670 680 690 720 730 740 750 760 770 pF1KE3 WPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 WPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 700 710 720 730 740 >>XP_016858415 (OMIM: 176873) PREDICTED: cyclin-dependen (781 aa) initn: 4110 init1: 4110 opt: 4162 Z-score: 1312.3 bits: 253.6 E(85289): 2.3e-66 Smith-Waterman score: 5010; 98.1% identity (98.2% similar) in 781 aa overlap (1-770:1-781) 10 20 30 40 50 60 pF1KE3 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKE--RE ::::::::::::::::::::::::::::::::::::.::::::::::: ::::::: :: XP_016 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRKHARVKEKERE 70 80 90 100 110 120 120 130 140 150 160 pF1KE3 HERRKRHREEQDKARREWERQKRREMAREHSRRER---------DRLEQLERKRERERKM ::::::::::::::::::::::::::::::::::: :::::::::::::::: XP_016 HERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERERKM 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE3 REQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 REQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRE 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE3 RFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEE 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE3 EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPE 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE3 SRFDRDSRESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRS ::::::: ::::::::::::::::::::::::::::::: :::::::::::::::::::: XP_016 SRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRS 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE3 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE3 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 490 500 510 520 530 540 530 540 550 560 570 580 pF1KE3 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKE 550 560 570 580 590 600 590 600 610 620 630 640 pF1KE3 YSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKM 610 620 630 640 650 660 650 660 670 680 690 700 pF1KE3 TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSM 670 680 690 700 710 720 710 720 730 740 750 760 pF1KE3 FPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLK 730 740 750 760 770 780 770 pF1KE3 F : XP_016 F >>XP_016858414 (OMIM: 176873) PREDICTED: cyclin-dependen (791 aa) initn: 4110 init1: 4110 opt: 4152 Z-score: 1309.2 bits: 253.0 E(85289): 3.5e-66 Smith-Waterman score: 4980; 96.8% identity (97.0% similar) in 791 aa overlap (1-770:1-791) 10 20 30 40 50 60 pF1KE3 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKW----------K ::::::::::::::::::::::::::::::::::::.::::::::::: : XP_016 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK 70 80 90 100 110 120 120 130 140 150 pF1KE3 HARVKE--REHERRKRHREEQDKARREWERQKRREMAREHSRRER---------DRLEQL :::::: ::::::::::::::::::::::::::::::::::::: :::::: XP_016 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQL 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE3 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE3 SRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE3 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE3 NENHLLVVPESRFDRDSRESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPK ::::::::::::::::: ::::::::::::::::::::::::::::::: :::::::::: XP_016 NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPK 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE3 YLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLR 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE3 EINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMI 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE3 QLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYR 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE3 APELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG 610 620 630 640 650 660 640 650 660 670 680 690 pF1KE3 YSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE3 ETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGA 730 740 750 760 770 780 760 770 pF1KE3 SAAGPGFSLKF ::::::::::: XP_016 SAAGPGFSLKF 790 >>NP_001300911 (OMIM: 116951) cyclin-dependent kinase 11 (779 aa) initn: 4092 init1: 4092 opt: 4137 Z-score: 1304.6 bits: 252.2 E(85289): 6.3e-66 Smith-Waterman score: 5020; 98.1% identity (98.5% similar) in 779 aa overlap (1-770:1-779) 10 20 30 40 50 60 pF1KE3 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::: NP_001 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHE 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 RRKRHREEQDKARREWERQKRREMAREHSRRER---------DRLEQLERKRERERKMRE ::::::::::::::::::::::::::::::::: :::::::::::::::::: NP_001 RRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERERKMRE 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE3 QQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERF 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 ELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 GSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESR 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE3 FDRDSRESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVE ::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVE 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE3 EFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPN 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE3 IVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDN 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE3 WILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYS :::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::: NP_001 WILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYS 550 560 570 580 590 600 600 610 620 630 640 650 pF1KE3 TAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTF ::::::::::::::::::::::::.:::::::::::.::::::::::::::::.:::::: NP_001 TAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTF 610 620 630 640 650 660 660 670 680 690 700 710 pF1KE3 SEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFP 670 680 690 700 710 720 720 730 740 750 760 770 pF1KE3 TWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 730 740 750 760 770 >>NP_277025 (OMIM: 176873) cyclin-dependent kinase 11B i (565 aa) initn: 3706 init1: 3706 opt: 3706 Z-score: 1173.6 bits: 227.5 E(85289): 1.2e-58 Smith-Waterman score: 3706; 99.6% identity (99.6% similar) in 565 aa overlap (206-770:1-565) 180 190 200 210 220 230 pF1KE3 QREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGD :::::::::::::::::::::::::::::: NP_277 MREDYSDKVKASHWSRSPPRPPRERFELGD 10 20 30 240 250 260 270 280 290 pF1KE3 GRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 GRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTS 40 50 60 70 80 90 300 310 320 330 340 350 pF1KE3 EESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 EESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRD 100 110 120 130 140 150 360 370 380 390 400 410 pF1KE3 SRESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQC : ::::::::::::::::::::::::::::::: :::::::::::::::::::::::::: NP_277 SGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQC 160 170 180 190 200 210 420 430 440 450 460 470 pF1KE3 LNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 LNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV 220 230 240 250 260 270 480 490 500 510 520 530 pF1KE3 REIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 REIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILH 280 290 300 310 320 330 540 550 560 570 580 590 pF1KE3 RDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 RDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVD 340 350 360 370 380 390 600 610 620 630 640 650 pF1KE3 MWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 MWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHP 400 410 420 430 440 450 660 670 680 690 700 710 pF1KE3 YNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 YNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPA 460 470 480 490 500 510 720 730 740 750 760 770 pF1KE3 KSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 KSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 520 530 540 550 560 >>NP_001778 (OMIM: 176873) cyclin-dependent kinase 11B i (795 aa) initn: 3451 init1: 3451 opt: 3657 Z-score: 1156.7 bits: 224.8 E(85289): 1.1e-57 Smith-Waterman score: 4968; 96.2% identity (96.5% similar) in 795 aa overlap (1-770:1-795) 10 20 30 40 50 60 pF1KE3 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKW----------K ::::::::::::::::::::::::::::::::::::.::::::::::: : NP_001 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK 70 80 90 100 110 120 120 130 140 150 160 pF1KE3 HARVKE--REHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK :::::: :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE3 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR 190 200 210 220 230 240 230 240 250 260 270 pF1KE3 ERFELGDGRKP-------------VKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG ::::::::::: .::::::::::::::::::::::::::::::::::: NP_001 ERFELGDGRKPGEARPAPAQKPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE3 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSED 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE3 EERENENHLLVVPESRFDRDSRESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQ ::::::::::::::::::::: ::::::::::::::::::::::::::::::: :::::: NP_001 EERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQ 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE3 ELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPI 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE3 TSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVK 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE3 TLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVT 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE3 LWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEK 610 620 630 640 650 660 640 650 660 670 680 690 pF1KE3 IWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKH 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE3 EYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTT 730 740 750 760 770 780 760 770 pF1KE3 NQGASAAGPGFSLKF ::::::::::::::: NP_001 NQGASAAGPGFSLKF 790 770 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 17:20:46 2016 done: Mon Nov 7 17:20:48 2016 Total Scan time: 11.750 Total Display time: 0.190 Function used was FASTA [36.3.4 Apr, 2011]