FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4270, 1125 aa 1>>>pF1KE4270 1125 - 1125 aa - 1125 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 13.0734+/-0.000456; mu= -14.1307+/- 0.028 mean_var=450.8347+/-92.811, 0's: 0 Z-trim(122.5): 57 B-trim: 1907 in 1/59 Lambda= 0.060404 statistics sampled from 40705 (40772) to 40705 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.764), E-opt: 0.2 (0.478), width: 16 Scan time: 16.420 The best scores are: opt bits E(85289) NP_001287780 (OMIM: 609424) roquin-1 isoform c [Ho (1125) 7669 683.7 1.6e-195 NP_001287781 (OMIM: 609424) roquin-1 isoform d [Ho (1124) 7652 682.2 4.6e-195 NP_742068 (OMIM: 609424) roquin-1 isoform b [Homo (1133) 7106 634.6 9.7e-181 NP_001287779 (OMIM: 609424) roquin-1 isoform a [Ho (1134) 6804 608.3 8.1e-173 XP_011507533 (OMIM: 609424) PREDICTED: roquin-1 is (1076) 6779 606.1 3.5e-172 XP_005244978 (OMIM: 609424) PREDICTED: roquin-1 is (1113) 3745 341.7 1.4e-92 NP_061323 (OMIM: 615231) roquin-2 isoform 2 [Homo (1064) 2710 251.5 1.9e-65 NP_001094058 (OMIM: 615231) roquin-2 isoform 1 [Ho (1191) 2710 251.6 2.1e-65 >>NP_001287780 (OMIM: 609424) roquin-1 isoform c [Homo s (1125 aa) initn: 7669 init1: 7669 opt: 7669 Z-score: 3631.0 bits: 683.7 E(85289): 1.6e-195 Smith-Waterman score: 7669; 100.0% identity (100.0% similar) in 1125 aa overlap (1-1125:1-1125) 10 20 30 40 50 60 pF1KE4 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE4 QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE4 VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE4 TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE4 MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE4 PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE4 AEREQLRLELQQLNHQISQQTQLRGLEREANTLAGQSQPPPPPPPKWPGMISSEQLSLEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEREQLRLELQQLNHQISQQTQLRGLEREANTLAGQSQPPPPPPPKWPGMISSEQLSLEL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE4 HQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLTLTFSSDVPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLTLTFSSDVPN 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 pF1KE4 GSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP ::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP 1090 1100 1110 1120 >>NP_001287781 (OMIM: 609424) roquin-1 isoform d [Homo s (1124 aa) initn: 7350 init1: 7350 opt: 7652 Z-score: 3623.0 bits: 682.2 E(85289): 4.6e-195 Smith-Waterman score: 7652; 99.9% identity (99.9% similar) in 1125 aa overlap (1-1125:1-1124) 10 20 30 40 50 60 pF1KE4 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE4 QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE4 VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE4 TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE4 MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE4 PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE4 AEREQLRLELQQLNHQISQQTQLRGLEREANTLAGQSQPPPPPPPKWPGMISSEQLSLEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEREQLRLELQQLNHQISQQTQLRGLEREANTLAGQSQPPPPPPPKWPGMISSEQLSLEL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE4 HQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLTLTFSSDVPN ::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::: NP_001 HQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLTLTFS-DVPN 1030 1040 1050 1060 1070 1090 1100 1110 1120 pF1KE4 GSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP ::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP 1080 1090 1100 1110 1120 >>NP_742068 (OMIM: 609424) roquin-1 isoform b [Homo sapi (1133 aa) initn: 7117 init1: 6766 opt: 7106 Z-score: 3365.8 bits: 634.6 E(85289): 9.7e-181 Smith-Waterman score: 7624; 99.1% identity (99.1% similar) in 1134 aa overlap (1-1125:1-1133) 10 20 30 40 50 60 pF1KE4 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE4 QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE4 VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE4 TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE4 MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE4 PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS 910 920 930 940 950 960 970 980 990 1000 1010 pF1KE4 AEREQLRLELQQLNHQISQQTQLRGLE---------REANTLAGQSQPPPPPPPKWPGMI ::::::::::::::::::::::::::: :::::::::::::::::::::::: NP_742 AEREQLRLELQQLNHQISQQTQLRGLEAVSNRLVLQREANTLAGQSQPPPPPPPKWPGMI 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KE4 SSEQLSLELHQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 SSEQLSLELHQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLT 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 pF1KE4 LTFSSDVPNGSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP :::: ::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 LTFS-DVPNGSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP 1090 1100 1110 1120 1130 >>NP_001287779 (OMIM: 609424) roquin-1 isoform a [Homo s (1134 aa) initn: 6812 init1: 6766 opt: 6804 Z-score: 3223.6 bits: 608.3 E(85289): 8.1e-173 Smith-Waterman score: 7641; 99.2% identity (99.2% similar) in 1134 aa overlap (1-1125:1-1134) 10 20 30 40 50 60 pF1KE4 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE4 QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE4 VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE4 TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE4 MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE4 PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS 910 920 930 940 950 960 970 980 990 1000 1010 pF1KE4 AEREQLRLELQQLNHQISQQTQLRGLE---------REANTLAGQSQPPPPPPPKWPGMI ::::::::::::::::::::::::::: :::::::::::::::::::::::: NP_001 AEREQLRLELQQLNHQISQQTQLRGLEAVSNRLVLQREANTLAGQSQPPPPPPPKWPGMI 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KE4 SSEQLSLELHQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSEQLSLELHQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLT 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 pF1KE4 LTFSSDVPNGSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTFSSDVPNGSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP 1090 1100 1110 1120 1130 >>XP_011507533 (OMIM: 609424) PREDICTED: roquin-1 isofor (1076 aa) initn: 6763 init1: 6763 opt: 6779 Z-score: 3212.1 bits: 606.1 E(85289): 3.5e-172 Smith-Waterman score: 7222; 95.6% identity (95.6% similar) in 1125 aa overlap (1-1125:1-1076) 10 20 30 40 50 60 pF1KE4 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE4 QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE4 VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE4 TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE4 MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE4 PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE4 AEREQLRLELQQLNHQISQQTQLRGLEREANTLAGQSQPPPPPPPKWPGMISSEQLSLEL ::::::::::::::::::::::::::: XP_011 AEREQLRLELQQLNHQISQQTQLRGLE--------------------------------- 970 980 1030 1040 1050 1060 1070 1080 pF1KE4 HQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLTLTFSSDVPN :::::::::::::::::::::::::::::::::::::::::::: XP_011 ----------------ENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLTLTFSSDVPN 990 1000 1010 1020 1030 1090 1100 1110 1120 pF1KE4 GSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP ::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP 1040 1050 1060 1070 >>XP_005244978 (OMIM: 609424) PREDICTED: roquin-1 isofor (1113 aa) initn: 4541 init1: 3601 opt: 3745 Z-score: 1783.0 bits: 341.7 E(85289): 1.4e-92 Smith-Waterman score: 7448; 97.4% identity (97.4% similar) in 1134 aa overlap (1-1125:1-1113) 10 20 30 40 50 60 pF1KE4 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDL- 490 500 510 520 530 550 560 570 580 590 600 pF1KE4 ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA :::::::::::::::::::::::::::::::::::::::: XP_005 --------------------GPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA 540 550 560 570 610 620 630 640 650 660 pF1KE4 PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ 580 590 600 610 620 630 670 680 690 700 710 720 pF1KE4 QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP 640 650 660 670 680 690 730 740 750 760 770 780 pF1KE4 VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP 700 710 720 730 740 750 790 800 810 820 830 840 pF1KE4 TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM 760 770 780 790 800 810 850 860 870 880 890 900 pF1KE4 MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA 820 830 840 850 860 870 910 920 930 940 950 960 pF1KE4 PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS 880 890 900 910 920 930 970 980 990 1000 1010 pF1KE4 AEREQLRLELQQLNHQISQQTQLRGLE---------REANTLAGQSQPPPPPPPKWPGMI ::::::::::::::::::::::::::: :::::::::::::::::::::::: XP_005 AEREQLRLELQQLNHQISQQTQLRGLEAVSNRLVLQREANTLAGQSQPPPPPPPKWPGMI 940 950 960 970 980 990 1020 1030 1040 1050 1060 1070 pF1KE4 SSEQLSLELHQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSEQLSLELHQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLT 1000 1010 1020 1030 1040 1050 1080 1090 1100 1110 1120 pF1KE4 LTFSSDVPNGSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LTFSSDVPNGSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP 1060 1070 1080 1090 1100 1110 >>NP_061323 (OMIM: 615231) roquin-2 isoform 2 [Homo sapi (1064 aa) initn: 2936 init1: 1939 opt: 2710 Z-score: 1295.8 bits: 251.5 E(85289): 1.9e-65 Smith-Waterman score: 3434; 53.8% identity (73.2% similar) in 1092 aa overlap (1-1046:1-1055) 10 20 30 40 50 60 pF1KE4 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD ::::: :::.::::::: . :::...:::::::.::::: :::::::::::::::.:::: NP_061 MPVQAAQWTEFLSCPICYNEFDENVHKPISLGCSHTVCKTCLNKLHRKACPFDQTAINTD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG :..:::: :::::::::::..: : : :.. ..:::: ::::::.:::::::::...::. NP_061 IDVLPVNFALLQLVGAQVPDHQSIKL-SNLGENKHYEVAKKCVEDLALYLKPLSGGKGVA 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS : .::.:::::::::::::.:::::::::.:::::::::::::::::::::::::::: NP_061 --SLNQSALSRPMQRKLVTLVNCQLVEEEGRVRAMRAARSLGERTVTELILQHQNPQQLS 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE4 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT .::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 ANLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP ::::::::::::::::::::::::::::::::::.:::::::::.:::.:::::::::.: NP_061 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRSYEALRREHDAQIVHIAMEAGLRISP 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE4 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL .::::::::: .:::::::::::::.: :::.:::::::.:::::::::::::::::::: NP_061 EQWSSLLYGDLAHKSHMQSIIDKLQSPESFAKSVQELTIVLQRTGDPANLNRLRPHLELL 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR :::::.::: ::::::::..:::.::::::::.:::.:.:: . :: .::::: ::: NP_061 ANIDPNPDAVSPTWEQLENAMVAVKTVVHGLVDFIQNYSRKGHETPQPQPNSKYKTSMCR 360 370 380 390 400 410 430 440 450 460 470 pF1KE4 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRL---VPRRPLSASLGQLNEVGLPSAAIL :..:.::::::..::::::::::::.: ::.. : :: ..: : : .. .. NP_061 DLRQQGGCPRGTNCTFAHSQEELEKYRLRNKKINATVRTFPLLNKVGVNNTVTTTAGNVI 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE4 PDEGAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSY---DSSLKPGKIDHLSSSAPG :... .. :. ::: .. :.:.::: :.:: . .. : ::. ...: : NP_061 SVIGSTETTGKIVPST-NGISNAENSVSQLISRSTDSTLRALETVKKVGKVGANGQNAAG 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE4 SPPD-LLESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQL--YPAQQTDV : . :. : ::. . ::... . : . : ... :: .. .. NP_061 PSADSVTENKIGSPPKTPVSNVAATSAGPSNVGTELNSVPQKSSPFLTRVPVYPPHSENI 540 550 560 570 580 590 600 610 620 630 pF1KE4 -YYQDPRGAAPPFEPAPYQQGMYYTPPPQ-------CVSRFVR----PPPSAPEPAPPYL :.:::: : :: : : :: ::: :: :::: : : : . :: NP_061 QYFQDPRTQIP-FEVPQYPQTGYYPPPPTVPAGVAPCVPRFVRSNNVPESSLPPASMPYA 600 610 620 630 640 650 640 650 660 670 680 690 pF1KE4 DHYPPYL-QERVVNSQYGTQPQQ----YPPI----YPSHYDGRRVYPAPSYTREEIFRES ::: . ..:. .: : : : ::. : ::.::.. : : :..:.: . NP_061 DHYSTFSPRDRMNSSPYQPPPPQPYGPVPPVPSGMYAPVYDSRRIWRPPMYQRDDIIRSN 660 670 680 690 700 710 700 710 720 730 740 pF1KE4 PIP-IEIPPAAVPSYVPESRERYQQIESYYPVAPHPTQIRPSYLREPPYSRLPPPPQP-- .: ... ..: : ::::.....:: :: .: :: : . .: : .: NP_061 SLPPMDVMHSSV--YQTSLRERYNSLDGYYSVACQP----PS----EPRTTVPLPREPCG 720 730 740 750 760 750 760 770 780 790 800 pF1KE4 H--PSLDELHRRRKEIMAQLEERK---VISPPPFAP-SPTLP-PTFHPEEFLDEDLKVAG : : .: ::. . :: . .: : : : : ::: : : : . : . .:.: NP_061 HLKTSCEEQIRRKPDQWAQYHTQKAPLVSSTLPVATQSPTPPSPLFSVDFRADFSESVSG 770 780 790 800 810 820 810 820 830 840 850 pF1KE4 -KYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEMMNVESKGM--RDQRLDLQR :.. . :.:::::: :::: :.. :..::::.: ... .:...: . : . .. :: NP_061 TKFEEDHLSHYSPWSCGTIGSCINAIDSEPKDVIANSNAVLMDLDSGDVKRRVHLFETQR 830 840 850 860 870 880 860 870 880 890 900 910 pF1KE4 RAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMAPQGAPTKSINISDYSPY :. : .: .:::.: : .:..:::::.:.: :. . :.:: : ::. :: :..::: :: NP_061 RTKE--EDPIIPFSDGPIISKWGAISRSSRTGYHTTDPVQATASQGSATKPISVSDYVPY 890 900 910 920 930 940 920 930 940 950 960 970 pF1KE4 --GTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPSAEREQLRLELQQLNH .. . : : :. .. :..:. ::.:. ......: : :. . : ::::: NP_061 VNAVDSRW--SSYG--NEATSSAHYVERDRFIVTDLSGHRKH--SSTGDLLSLELQQ--- 950 960 970 980 990 980 990 1000 1010 1020 1030 pF1KE4 QISQQTQLRGLEREANTLAGQSQPPPPPPPKWPGMISSEQLSLELHQVEREI-GKRTREL .....: :.::::.:: :. :: .. ...:.:.: . : :. . ....: NP_061 --AKSNSLL-LQREANALAMQQ--------KWNSLDEGRHLTLNLLSKEIELRNGEVKKL 1000 1010 1020 1030 1040 1040 1050 1060 1070 1080 1090 pF1KE4 SMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLTLTFSSDVPNGSALTQENISLLSN .. .: . . : NP_061 NLSASCLMYLFSAAASWLYHY 1050 1060 >>NP_001094058 (OMIM: 615231) roquin-2 isoform 1 [Homo s (1191 aa) initn: 2936 init1: 1939 opt: 2710 Z-score: 1295.1 bits: 251.6 E(85289): 2.1e-65 Smith-Waterman score: 3444; 52.7% identity (72.3% similar) in 1138 aa overlap (1-1084:1-1099) 10 20 30 40 50 60 pF1KE4 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD ::::: :::.::::::: . :::...:::::::.::::: :::::::::::::::.:::: NP_001 MPVQAAQWTEFLSCPICYNEFDENVHKPISLGCSHTVCKTCLNKLHRKACPFDQTAINTD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG :..:::: :::::::::::..: : : :.. ..:::: ::::::.:::::::::...::. NP_001 IDVLPVNFALLQLVGAQVPDHQSIKL-SNLGENKHYEVAKKCVEDLALYLKPLSGGKGVA 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS : .::.:::::::::::::.:::::::::.:::::::::::::::::::::::::::: NP_001 --SLNQSALSRPMQRKLVTLVNCQLVEEEGRVRAMRAARSLGERTVTELILQHQNPQQLS 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE4 SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT .::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP ::::::::::::::::::::::::::::::::::.:::::::::.:::.:::::::::.: NP_001 SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRSYEALRREHDAQIVHIAMEAGLRISP 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE4 DQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELL .::::::::: .:::::::::::::.: :::.:::::::.:::::::::::::::::::: NP_001 EQWSSLLYGDLAHKSHMQSIIDKLQSPESFAKSVQELTIVLQRTGDPANLNRLRPHLELL 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR :::::.::: ::::::::..:::.::::::::.:::.:.:: . :: .::::: ::: NP_001 ANIDPNPDAVSPTWEQLENAMVAVKTVVHGLVDFIQNYSRKGHETPQPQPNSKYKTSMCR 360 370 380 390 400 410 430 440 450 460 470 pF1KE4 DMKQRGGCPRGASCTFAHSQEELEKFRKMNKRL---VPRRPLSASLGQLNEVGLPSAAIL :..:.::::::..::::::::::::.: ::.. : :: ..: : : .. .. NP_001 DLRQQGGCPRGTNCTFAHSQEELEKYRLRNKKINATVRTFPLLNKVGVNNTVTTTAGNVI 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE4 PDEGAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSY---DSSLKPGKIDHLSSSAPG :... .. :. ::: .. :.:.::: :.:: . .. : ::. ...: : NP_001 SVIGSTETTGKIVPST-NGISNAENSVSQLISRSTDSTLRALETVKKVGKVGANGQNAAG 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE4 SPPD-LLESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQL--YPAQQTDV : . :. : ::. . ::... . : . : ... :: .. .. NP_001 PSADSVTENKIGSPPKTPVSNVAATSAGPSNVGTELNSVPQKSSPFLTRVPVYPPHSENI 540 550 560 570 580 590 600 610 620 630 pF1KE4 -YYQDPRGAAPPFEPAPYQQGMYYTPPPQ-------CVSRFVR----PPPSAPEPAPPYL :.:::: : :: : : :: ::: :: :::: : : : . :: NP_001 QYFQDPRTQIP-FEVPQYPQTGYYPPPPTVPAGVAPCVPRFVRSNNVPESSLPPASMPYA 600 610 620 630 640 650 640 650 660 670 680 690 pF1KE4 DHYPPYL-QERVVNSQYGTQPQQ----YPPI----YPSHYDGRRVYPAPSYTREEIFRES ::: . ..:. .: : : : ::. : ::.::.. : : :..:.: . NP_001 DHYSTFSPRDRMNSSPYQPPPPQPYGPVPPVPSGMYAPVYDSRRIWRPPMYQRDDIIRSN 660 670 680 690 700 710 700 710 720 730 740 pF1KE4 PIP-IEIPPAAVPSYVPESRERYQQIESYYPVAPHPTQIRPSYLREPPYSRLPPPPQP-- .: ... ..: : ::::.....:: :: .: :: : . .: : .: NP_001 SLPPMDVMHSSV--YQTSLRERYNSLDGYYSVACQP----PS----EPRTTVPLPREPCG 720 730 740 750 760 750 760 770 780 790 800 pF1KE4 H--PSLDELHRRRKEIMAQLEERK---VISPPPFAP-SPTLP-PTFHPEEFLDEDLKVAG : : .: ::. . :: . .: : : : : ::: : : : . : . .:.: NP_001 HLKTSCEEQIRRKPDQWAQYHTQKAPLVSSTLPVATQSPTPPSPLFSVDFRADFSESVSG 770 780 790 800 810 820 810 820 830 840 850 pF1KE4 -KYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEMMNVESKGM--RDQRLDLQR :.. . :.:::::: :::: :.. :..::::.: ... .:...: . : . .. :: NP_001 TKFEEDHLSHYSPWSCGTIGSCINAIDSEPKDVIANSNAVLMDLDSGDVKRRVHLFETQR 830 840 850 860 870 880 860 870 880 890 900 910 pF1KE4 RAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMAPQGAPTKSINISDYSPY :. : .: .:::.: : .:..:::::.:.: :. . :.:: : ::. :: :..::: :: NP_001 RTKE--EDPIIPFSDGPIISKWGAISRSSRTGYHTTDPVQATASQGSATKPISVSDYVPY 890 900 910 920 930 940 920 930 940 950 960 970 pF1KE4 --GTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPSAEREQLRLELQQLNH .. . : : :. .. :..:. ::.:. ......: : :. . : ::::: NP_001 VNAVDSRW--SSYG--NEATSSAHYVERDRFIVTDLSGHRK--HSSTGDLLSLELQQ--- 950 960 970 980 990 980 990 1000 1010 1020 1030 pF1KE4 QISQQTQLRGLEREANTLAGQSQPPPPPPPKWPGMISSEQLSLELHQVEREIGKRTREL- .....: :.::::.:: :. :: .. ...:.:.: . .:: :. :: NP_001 --AKSNSLL-LQREANALAMQQ--------KWNSLDEGRHLTLNL--LSKEIELRNGELQ 1000 1010 1020 1030 1040 1040 1050 1060 1070 1080 pF1KE4 ------SMENQCSLDMKSKLNTSKQAE-NGQPEPQNKVPAEDLTLTFSSD-VPNGSALTQ . ... . :.. .:.. : .:: :: ... .: .. ..: . :: :. NP_001 SDYTEDATDTKPDRDIELELSALDTDEPDGQSEPIEEILDIQLGISSQNDQLLNGMAVEN 1050 1060 1070 1080 1090 1100 1090 1100 1110 1120 pF1KE4 ENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP NP_001 GHPVQQHQKEPPKQKKQSLGEDHVILEEQKTILPVTSCFSQPLPVSISNASCLPITTSVS 1110 1120 1130 1140 1150 1160 1125 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 17:20:07 2016 done: Mon Nov 7 17:20:09 2016 Total Scan time: 16.420 Total Display time: 0.360 Function used was FASTA [36.3.4 Apr, 2011]