FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6481, 311 aa 1>>>pF1KB6481 311 - 311 aa - 311 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.6140+/-0.00027; mu= 11.4260+/- 0.017 mean_var=138.8280+/-28.302, 0's: 0 Z-trim(123.4): 165 B-trim: 95 in 1/56 Lambda= 0.108852 statistics sampled from 42913 (43123) to 42913 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.819), E-opt: 0.2 (0.506), width: 16 Scan time: 8.610 The best scores are: opt bits E(85289) NP_919442 (OMIM: 615177) E3 ubiquitin-protein liga ( 311) 2199 356.0 5.8e-98 XP_005259651 (OMIM: 615177) PREDICTED: E3 ubiquiti ( 284) 1141 189.8 5.6e-48 NP_071763 (OMIM: 300420) E3 ubiquitin-protein liga ( 455) 278 54.4 5e-07 XP_005262349 (OMIM: 300420) PREDICTED: E3 ubiquiti ( 588) 278 54.5 6e-07 NP_001027568 (OMIM: 300420) E3 ubiquitin-protein l ( 588) 278 54.5 6e-07 NP_660095 (OMIM: 300420) E3 ubiquitin-protein liga ( 643) 278 54.6 6.4e-07 XP_011529313 (OMIM: 300420) PREDICTED: E3 ubiquiti ( 643) 278 54.6 6.4e-07 NP_057578 (OMIM: 612490) E3 ubiquitin-protein liga ( 153) 240 48.0 1.4e-05 XP_016869786 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 402) 238 48.1 3.5e-05 XP_016869785 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 402) 238 48.1 3.5e-05 NP_919309 (OMIM: 612488) E3 ubiquitin-protein liga ( 432) 238 48.1 3.7e-05 XP_005251424 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 238 48.1 3.7e-05 NP_919311 (OMIM: 612488) E3 ubiquitin-protein liga ( 432) 238 48.1 3.7e-05 XP_005251425 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 238 48.1 3.7e-05 XP_016869784 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 238 48.1 3.7e-05 XP_005251423 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 238 48.1 3.7e-05 NP_919313 (OMIM: 612488) E3 ubiquitin-protein liga ( 432) 238 48.1 3.7e-05 XP_006716784 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 238 48.1 3.7e-05 XP_011516015 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 238 48.1 3.7e-05 XP_011516014 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 238 48.1 3.7e-05 XP_016869783 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 444) 238 48.1 3.8e-05 NP_919310 (OMIM: 612488) E3 ubiquitin-protein liga ( 465) 238 48.2 3.9e-05 NP_073618 (OMIM: 612488) E3 ubiquitin-protein liga ( 515) 238 48.2 4.2e-05 NP_005968 (OMIM: 133239,604242) E3 ubiquitin-prote ( 685) 232 47.4 0.0001 NP_898864 (OMIM: 133239,604242) E3 ubiquitin-prote ( 685) 232 47.4 0.0001 XP_005266542 (OMIM: 133239,604242) PREDICTED: E3 u ( 685) 232 47.4 0.0001 XP_005266543 (OMIM: 133239,604242) PREDICTED: E3 u ( 685) 232 47.4 0.0001 XP_011533479 (OMIM: 133239,604242) PREDICTED: E3 u ( 685) 232 47.4 0.0001 NP_898865 (OMIM: 133239,604242) E3 ubiquitin-prote ( 685) 232 47.4 0.0001 NP_057204 (OMIM: 300379,300978) E3 ubiquitin-prote ( 624) 202 42.6 0.0024 NP_899196 (OMIM: 300379,300978) E3 ubiquitin-prote ( 624) 202 42.6 0.0024 NP_001307293 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 195 41.3 0.0032 NP_001307294 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 195 41.3 0.0032 NP_001307292 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 195 41.3 0.0032 NP_001307291 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 195 41.3 0.0032 NP_115549 (OMIM: 612062) E3 ubiquitin-protein liga ( 836) 201 42.6 0.0034 XP_016884479 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 201 42.6 0.0034 XP_011528740 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 201 42.6 0.0034 XP_011528738 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 201 42.6 0.0034 XP_011528739 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 201 42.6 0.0034 XP_011528737 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 201 42.6 0.0034 NP_001310440 (OMIM: 603243) E3 ubiquitin-protein l ( 548) 198 41.9 0.0034 XP_005255947 (OMIM: 603243) PREDICTED: E3 ubiquiti ( 548) 198 41.9 0.0034 NP_001307288 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 195 41.3 0.0034 NP_001307286 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 195 41.3 0.0034 XP_016879916 (OMIM: 610431) PREDICTED: E3 ubiquiti ( 350) 195 41.3 0.0034 NP_001307287 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 195 41.3 0.0034 NP_056343 (OMIM: 610431) E3 ubiquitin-protein liga ( 350) 195 41.3 0.0034 NP_001307285 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 195 41.3 0.0034 NP_001307290 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 195 41.3 0.0034 >>NP_919442 (OMIM: 615177) E3 ubiquitin-protein ligase R (311 aa) initn: 2199 init1: 2199 opt: 2199 Z-score: 1879.7 bits: 356.0 E(85289): 5.8e-98 Smith-Waterman score: 2199; 100.0% identity (100.0% similar) in 311 aa overlap (1-311:1-311) 10 20 30 40 50 60 pF1KB6 MAEASPHPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEETRSTENGSAPSTAPTDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_919 MAEASPHPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEETRSTENGSAPSTAPTDQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 SRPPLEHVDQHLFTLPQGYGQFAFGIFDDSFEIPTFPPGAQADDGRDPESRRERDHPSRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_919 SRPPLEHVDQHLFTLPQGYGQFAFGIFDDSFEIPTFPPGAQADDGRDPESRRERDHPSRH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 RYGARQPRARLTTRRATGRHEGVPTLEGIIQQLVNGIITPATIPSLGPWGVLHSNPMDYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_919 RYGARQPRARLTTRRATGRHEGVPTLEGIIQQLVNGIITPATIPSLGPWGVLHSNPMDYA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 WGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKDDYALGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_919 WGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKDDYALGE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 RVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNTATNPPGLTGVSFSSSSSSSSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_919 RVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNTATNPPGLTGVSFSSSSSSSSSS 250 260 270 280 290 300 310 pF1KB6 SPSNENATSNS ::::::::::: NP_919 SPSNENATSNS 310 >>XP_005259651 (OMIM: 615177) PREDICTED: E3 ubiquitin-pr (284 aa) initn: 2004 init1: 1131 opt: 1141 Z-score: 982.3 bits: 189.8 E(85289): 5.6e-48 Smith-Waterman score: 1954; 91.3% identity (91.3% similar) in 311 aa overlap (1-311:1-284) 10 20 30 40 50 60 pF1KB6 MAEASPHPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEETRSTENGSAPSTAPTDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAEASPHPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEETRSTENGSAPSTAPTDQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 SRPPLEHVDQHLFTLPQGYGQFAFGIFDDSFEIPTFPPGAQADDGRDPESRRERDHPSRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SRPPLEHVDQHLFTLPQGYGQFAFGIFDDSFEIPTFPPGAQADDGRDPESRRERDHPSRH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 RYGARQPRARLTTRRATGRHEGVPTLEGIIQQLVNGIITPATIPSLGPWGVLHSNPMDYA : :::::::::::::::::::::::::::::::: XP_005 R---------------------------IIQQLVNGIITPATIPSLGPWGVLHSNPMDYA 130 140 150 190 200 210 220 230 240 pF1KB6 WGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKDDYALGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKDDYALGE 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB6 RVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNTATNPPGLTGVSFSSSSSSSSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNTATNPPGLTGVSFSSSSSSSSSS 220 230 240 250 260 270 310 pF1KB6 SPSNENATSNS ::::::::::: XP_005 SPSNENATSNS 280 >>NP_071763 (OMIM: 300420) E3 ubiquitin-protein ligase P (455 aa) initn: 278 init1: 203 opt: 278 Z-score: 247.2 bits: 54.4 E(85289): 5e-07 Smith-Waterman score: 278; 50.0% identity (75.7% similar) in 70 aa overlap (203-270:379-448) 180 190 200 210 220 230 pF1KB6 HSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEH--VGSGLECP :::.::.:.::: . :::.: ::. . :: NP_071 YMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCCP 350 360 370 380 390 400 240 250 260 270 280 290 pF1KB6 VCKDDYALGERVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNTATNPPGLTGVSF .: ..:. :: . .:::.: :: :. ::.. .::::: NP_071 ICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL 410 420 430 440 450 300 310 pF1KB6 SSSSSSSSSSSPSNENATSNS >>XP_005262349 (OMIM: 300420) PREDICTED: E3 ubiquitin-pr (588 aa) initn: 302 init1: 203 opt: 278 Z-score: 245.8 bits: 54.5 E(85289): 6e-07 Smith-Waterman score: 278; 50.0% identity (75.7% similar) in 70 aa overlap (203-270:512-581) 180 190 200 210 220 230 pF1KB6 HSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEH--VGSGLECP :::.::.:.::: . :::.: ::. . :: XP_005 YMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCCP 490 500 510 520 530 540 240 250 260 270 280 290 pF1KB6 VCKDDYALGERVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNTATNPPGLTGVSF .: ..:. :: . .:::.: :: :. ::.. .::::: XP_005 ICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL 550 560 570 580 300 310 pF1KB6 SSSSSSSSSSSPSNENATSNS >>NP_001027568 (OMIM: 300420) E3 ubiquitin-protein ligas (588 aa) initn: 302 init1: 203 opt: 278 Z-score: 245.8 bits: 54.5 E(85289): 6e-07 Smith-Waterman score: 278; 50.0% identity (75.7% similar) in 70 aa overlap (203-270:512-581) 180 190 200 210 220 230 pF1KB6 HSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEH--VGSGLECP :::.::.:.::: . :::.: ::. . :: NP_001 YMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCCP 490 500 510 520 530 540 240 250 260 270 280 290 pF1KB6 VCKDDYALGERVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNTATNPPGLTGVSF .: ..:. :: . .:::.: :: :. ::.. .::::: NP_001 ICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL 550 560 570 580 300 310 pF1KB6 SSSSSSSSSSSPSNENATSNS >>NP_660095 (OMIM: 300420) E3 ubiquitin-protein ligase P (643 aa) initn: 330 init1: 203 opt: 278 Z-score: 245.3 bits: 54.6 E(85289): 6.4e-07 Smith-Waterman score: 278; 50.0% identity (75.7% similar) in 70 aa overlap (203-270:567-636) 180 190 200 210 220 230 pF1KB6 HSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEH--VGSGLECP :::.::.:.::: . :::.: ::. . :: NP_660 YMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCCP 540 550 560 570 580 590 240 250 260 270 280 290 pF1KB6 VCKDDYALGERVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNTATNPPGLTGVSF .: ..:. :: . .:::.: :: :. ::.. .::::: NP_660 ICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL 600 610 620 630 640 300 310 pF1KB6 SSSSSSSSSSSPSNENATSNS >>XP_011529313 (OMIM: 300420) PREDICTED: E3 ubiquitin-pr (643 aa) initn: 330 init1: 203 opt: 278 Z-score: 245.3 bits: 54.6 E(85289): 6.4e-07 Smith-Waterman score: 278; 50.0% identity (75.7% similar) in 70 aa overlap (203-270:567-636) 180 190 200 210 220 230 pF1KB6 HSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEH--VGSGLECP :::.::.:.::: . :::.: ::. . :: XP_011 YMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCCP 540 550 560 570 580 590 240 250 260 270 280 290 pF1KB6 VCKDDYALGERVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNTATNPPGLTGVSF .: ..:. :: . .:::.: :: :. ::.. .::::: XP_011 ICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL 600 610 620 630 640 300 310 pF1KB6 SSSSSSSSSSSPSNENATSNS >>NP_057578 (OMIM: 612490) E3 ubiquitin-protein ligase R (153 aa) initn: 238 init1: 197 opt: 240 Z-score: 221.1 bits: 48.0 E(85289): 1.4e-05 Smith-Waterman score: 240; 36.7% identity (64.4% similar) in 90 aa overlap (184-273:33-120) 160 170 180 190 200 210 pF1KB6 VNGIITPATIPSLGPWGVLHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQAL : .: :. .... :::: : .. : NP_057 SYFDEHDCEPSDPEQETRTNMLLELARSLFNRMDFEDLGLVVDWDHHLPPPAAKTVVENL 10 20 30 40 50 60 220 230 240 250 260 270 pF1KB6 PTVPVTEEHVGSGLECPVCKDDYALGERVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSL : . . . . :.:::: .. : . ..::.::::..::.::: . .:::.:: : NP_057 PRTVIRGSQ--AELKCPVCLLEFEEEETAIEMPCHHLFHSSCILPWLSKTNSCPLCRYEL 70 80 90 100 110 120 280 290 300 310 pF1KB6 TGQNTATNPPGLTGVSFSSSSSSSSSSSPSNENATSNS NP_057 PTDDDTYEEHRRDKARKQQQQHRLENLHGAMYT 130 140 150 >>XP_016869786 (OMIM: 612488) PREDICTED: E3 ubiquitin-pr (402 aa) initn: 194 init1: 167 opt: 238 Z-score: 214.0 bits: 48.1 E(85289): 3.5e-05 Smith-Waterman score: 240; 28.5% identity (46.4% similar) in 274 aa overlap (16-270:138-391) 10 20 30 40 pF1KB6 MAEASPHPGRYFCHCCSVEIVPRLPDYICPRCESG--FIEELPEE :::. .: .: : :. :. . :. XP_016 CSTQQVPGCSVVFSGQHLPVCSVPPPMLQACSVQHLP-VPYAAFPPLISSDPFLIHPPHL 110 120 130 140 150 160 50 60 70 80 90 pF1KB6 TRSTENGSAP--STAP--TDQSRPPLEHVDQHLFTLPQGYGQFAFGIFDDSFEIPTFPPG . : . .: :.::: ::....... : . .: . : . ::.::. XP_016 SPHHPPHLPPPGQFVPFQTQQSRSPLQRIENEVELLGEHLPVGGF-TYPPSAHPPTLPPS 170 180 190 200 210 220 100 110 120 130 140 150 pF1KB6 AQADDGRDPESRRERDHPSRHRYGARQPRARLTTRRATGRHEGVPTLEGIIQQLVNGIIT : : . .: : ... . : . :: ::: . :: : XP_016 A-------PLQFLTHD-PLHQEVSFGVPYPPFMPRRLTGRSRYRS------QQ---PIPP 230 240 250 260 160 170 180 190 200 pF1KB6 PATIPSLGPWGVLHSNPMDYAWGA---------NGLDAIITQLLNQFENTG---PPPADK : ::: :. :: :. : : .: ::: : : : : XP_016 PPYHPSLLPY-VLSMLPVPPAVGPTFSFELDVEDGEVENYEALLNLAERLGEAKPRGLTK 270 280 290 300 310 320 210 220 230 240 250 260 pF1KB6 EKIQALPTVPVT-EEHVGSGLECPVCKDDYALGERVRQLPCNHLFHDGCIVPWLEQHDSC :. ::. . ..: . : :: :. . .: ::::: :: :. ::. . .: XP_016 ADIEQLPSYRFNPNNHQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVDKWLKANRTC 330 340 350 360 370 380 270 280 290 300 310 pF1KB6 PVCRKSLTGQNTATNPPGLTGVSFSSSSSSSSSSSPSNENATSNS :.:: XP_016 PICRADASEVHRDSE 390 400 >>XP_016869785 (OMIM: 612488) PREDICTED: E3 ubiquitin-pr (402 aa) initn: 194 init1: 167 opt: 238 Z-score: 214.0 bits: 48.1 E(85289): 3.5e-05 Smith-Waterman score: 240; 28.5% identity (46.4% similar) in 274 aa overlap (16-270:138-391) 10 20 30 40 pF1KB6 MAEASPHPGRYFCHCCSVEIVPRLPDYICPRCESG--FIEELPEE :::. .: .: : :. :. . :. XP_016 CSTQQVPGCSVVFSGQHLPVCSVPPPMLQACSVQHLP-VPYAAFPPLISSDPFLIHPPHL 110 120 130 140 150 160 50 60 70 80 90 pF1KB6 TRSTENGSAP--STAP--TDQSRPPLEHVDQHLFTLPQGYGQFAFGIFDDSFEIPTFPPG . : . .: :.::: ::....... : . .: . : . ::.::. XP_016 SPHHPPHLPPPGQFVPFQTQQSRSPLQRIENEVELLGEHLPVGGF-TYPPSAHPPTLPPS 170 180 190 200 210 220 100 110 120 130 140 150 pF1KB6 AQADDGRDPESRRERDHPSRHRYGARQPRARLTTRRATGRHEGVPTLEGIIQQLVNGIIT : : . .: : ... . : . :: ::: . :: : XP_016 A-------PLQFLTHD-PLHQEVSFGVPYPPFMPRRLTGRSRYRS------QQ---PIPP 230 240 250 260 160 170 180 190 200 pF1KB6 PATIPSLGPWGVLHSNPMDYAWGA---------NGLDAIITQLLNQFENTG---PPPADK : ::: :. :: :. : : .: ::: : : : : XP_016 PPYHPSLLPY-VLSMLPVPPAVGPTFSFELDVEDGEVENYEALLNLAERLGEAKPRGLTK 270 280 290 300 310 320 210 220 230 240 250 260 pF1KB6 EKIQALPTVPVT-EEHVGSGLECPVCKDDYALGERVRQLPCNHLFHDGCIVPWLEQHDSC :. ::. . ..: . : :: :. . .: ::::: :: :. ::. . .: XP_016 ADIEQLPSYRFNPNNHQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVDKWLKANRTC 330 340 350 360 370 380 270 280 290 300 310 pF1KB6 PVCRKSLTGQNTATNPPGLTGVSFSSSSSSSSSSSPSNENATSNS :.:: XP_016 PICRADASEVHRDSE 390 400 311 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 17:05:51 2016 done: Mon Nov 7 17:05:53 2016 Total Scan time: 8.610 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]