FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3042, 182 aa 1>>>pF1KE3042 182 - 182 aa - 182 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9294+/-0.000278; mu= 12.0769+/- 0.018 mean_var=109.8206+/-22.037, 0's: 0 Z-trim(121.1): 23 B-trim: 71 in 1/56 Lambda= 0.122386 statistics sampled from 37284 (37307) to 37284 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.767), E-opt: 0.2 (0.437), width: 16 Scan time: 5.920 The best scores are: opt bits E(85289) NP_853531 (OMIM: 607886) CKLF-like MARVEL transmem ( 182) 1227 226.1 2.4e-59 XP_006721194 (OMIM: 607886) PREDICTED: CKLF-like M ( 182) 1227 226.1 2.4e-59 NP_653202 (OMIM: 607886) CKLF-like MARVEL transmem ( 182) 1227 226.1 2.4e-59 XP_011521163 (OMIM: 607886) PREDICTED: CKLF-like M ( 150) 726 137.6 9e-33 NP_612469 (OMIM: 607888) CKLF-like MARVEL transmem ( 156) 336 68.7 5e-12 XP_016876442 (OMIM: 607888) PREDICTED: CKLF-like M ( 156) 336 68.7 5e-12 XP_016876443 (OMIM: 607888) PREDICTED: CKLF-like M ( 156) 336 68.7 5e-12 NP_002659 (OMIM: 300112) proteolipid protein 2 [Ho ( 152) 217 47.7 1e-05 NP_001032365 (OMIM: 607888) CKLF-like MARVEL trans ( 125) 197 44.1 0.0001 NP_001275675 (OMIM: 607888) CKLF-like MARVEL trans ( 223) 184 42.0 0.00077 NP_852662 (OMIM: 607887) CKLF-like MARVEL transmem ( 208) 168 39.2 0.0052 XP_016878443 (OMIM: 607887) PREDICTED: CKLF-like M ( 221) 168 39.2 0.0054 NP_848933 (OMIM: 607887) CKLF-like MARVEL transmem ( 234) 168 39.2 0.0057 >>NP_853531 (OMIM: 607886) CKLF-like MARVEL transmembran (182 aa) initn: 1227 init1: 1227 opt: 1227 Z-score: 1186.3 bits: 226.1 E(85289): 2.4e-59 Smith-Waterman score: 1227; 100.0% identity (100.0% similar) in 182 aa overlap (1-182:1-182) 10 20 30 40 50 60 pF1KE3 MWPPDPDPDPDPEPAGGSRPGPAVPGLRALLPARAFLCSLKGRLLLAESGLSFITFICYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_853 MWPPDPDPDPDPEPAGGSRPGPAVPGLRALLPARAFLCSLKGRLLLAESGLSFITFICYV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 ASSASAFLTAPLLEFLLALYFLFADAMQLNDKWQGLCWPMMDFLRCVTAALIYFAISITA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_853 ASSASAFLTAPLLEFLLALYFLFADAMQLNDKWQGLCWPMMDFLRCVTAALIYFAISITA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 IAKYSDGASKAAGVFGFFATIVFATDFYLIFNDVAKFLKQGDSADETTAHKTEEENSDSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_853 IAKYSDGASKAAGVFGFFATIVFATDFYLIFNDVAKFLKQGDSADETTAHKTEEENSDSD 130 140 150 160 170 180 pF1KE3 SD :: NP_853 SD >>XP_006721194 (OMIM: 607886) PREDICTED: CKLF-like MARVE (182 aa) initn: 1227 init1: 1227 opt: 1227 Z-score: 1186.3 bits: 226.1 E(85289): 2.4e-59 Smith-Waterman score: 1227; 100.0% identity (100.0% similar) in 182 aa overlap (1-182:1-182) 10 20 30 40 50 60 pF1KE3 MWPPDPDPDPDPEPAGGSRPGPAVPGLRALLPARAFLCSLKGRLLLAESGLSFITFICYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MWPPDPDPDPDPEPAGGSRPGPAVPGLRALLPARAFLCSLKGRLLLAESGLSFITFICYV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 ASSASAFLTAPLLEFLLALYFLFADAMQLNDKWQGLCWPMMDFLRCVTAALIYFAISITA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ASSASAFLTAPLLEFLLALYFLFADAMQLNDKWQGLCWPMMDFLRCVTAALIYFAISITA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 IAKYSDGASKAAGVFGFFATIVFATDFYLIFNDVAKFLKQGDSADETTAHKTEEENSDSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IAKYSDGASKAAGVFGFFATIVFATDFYLIFNDVAKFLKQGDSADETTAHKTEEENSDSD 130 140 150 160 170 180 pF1KE3 SD :: XP_006 SD >>NP_653202 (OMIM: 607886) CKLF-like MARVEL transmembran (182 aa) initn: 1227 init1: 1227 opt: 1227 Z-score: 1186.3 bits: 226.1 E(85289): 2.4e-59 Smith-Waterman score: 1227; 100.0% identity (100.0% similar) in 182 aa overlap (1-182:1-182) 10 20 30 40 50 60 pF1KE3 MWPPDPDPDPDPEPAGGSRPGPAVPGLRALLPARAFLCSLKGRLLLAESGLSFITFICYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 MWPPDPDPDPDPEPAGGSRPGPAVPGLRALLPARAFLCSLKGRLLLAESGLSFITFICYV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 ASSASAFLTAPLLEFLLALYFLFADAMQLNDKWQGLCWPMMDFLRCVTAALIYFAISITA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 ASSASAFLTAPLLEFLLALYFLFADAMQLNDKWQGLCWPMMDFLRCVTAALIYFAISITA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 IAKYSDGASKAAGVFGFFATIVFATDFYLIFNDVAKFLKQGDSADETTAHKTEEENSDSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 IAKYSDGASKAAGVFGFFATIVFATDFYLIFNDVAKFLKQGDSADETTAHKTEEENSDSD 130 140 150 160 170 180 pF1KE3 SD :: NP_653 SD >>XP_011521163 (OMIM: 607886) PREDICTED: CKLF-like MARVE (150 aa) initn: 796 init1: 721 opt: 726 Z-score: 709.4 bits: 137.6 E(85289): 9e-33 Smith-Waterman score: 957; 82.4% identity (82.4% similar) in 182 aa overlap (1-182:1-150) 10 20 30 40 50 60 pF1KE3 MWPPDPDPDPDPEPAGGSRPGPAVPGLRALLPARAFLCSLKGRLLLAESGLSFITFICYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MWPPDPDPDPDPEPAGGSRPGPAVPGLRALLPARAFLCSLKGRLLLAESGLSFITFICYV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 ASSASAFLTAPLLEFLLALYFLFADAMQLNDKWQGLCWPMMDFLRCVTAALIYFAISITA ::::::::::::::::::::::::::::::::::::::::: XP_011 ASSASAFLTAPLLEFLLALYFLFADAMQLNDKWQGLCWPMM------------------- 70 80 90 100 130 140 150 160 170 180 pF1KE3 IAKYSDGASKAAGVFGFFATIVFATDFYLIFNDVAKFLKQGDSADETTAHKTEEENSDSD ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 -------------VFGFFATIVFATDFYLIFNDVAKFLKQGDSADETTAHKTEEENSDSD 110 120 130 140 pF1KE3 SD :: XP_011 SD 150 >>NP_612469 (OMIM: 607888) CKLF-like MARVEL transmembran (156 aa) initn: 204 init1: 204 opt: 336 Z-score: 337.0 bits: 68.7 E(85289): 5e-12 Smith-Waterman score: 336; 42.1% identity (73.6% similar) in 140 aa overlap (24-162:17-154) 10 20 30 40 50 60 pF1KE3 MWPPDPDPDPDPEPAGGSRPGPAVPGLRALLPARAFLCSLKGRLLLAESGLSFITFICYV : :... .::: : :: :: .: .:..: :::.. NP_612 MLSARDRRDRHPEEGVVAELQGFAVDKAFLTSHKGILLETELALTLIIFICFT 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 ASSASAFLTAPLLEFLLALYFLFADAMQLNDKWQGLCWPMMDFLRCVTAALIYFAISITA :: ::...: ::::...: ::: : : .... . :: .::::::.: .:....:..: NP_612 AS-ISAYMAAALLEFFITLAFLFLYATQYYQRFDRINWPCLDFLRCVSAIIIFLVVSFAA 60 70 80 90 100 110 130 140 150 160 170 pF1KE3 IAKYSDGASKAAGVFGFFATIVFATDFYLIF-NDVAKFLKQGDSADETTAHKTEEENSDS ... :::. :: :::.. . .:: : . :. ...: .::: NP_612 VTSR-DGAAIAAFVFGIILVSIFAYDAFKIYRTEMAPGASQGDQQ 120 130 140 150 180 pF1KE3 DSD >>XP_016876442 (OMIM: 607888) PREDICTED: CKLF-like MARVE (156 aa) initn: 204 init1: 204 opt: 336 Z-score: 337.0 bits: 68.7 E(85289): 5e-12 Smith-Waterman score: 336; 42.1% identity (73.6% similar) in 140 aa overlap (24-162:17-154) 10 20 30 40 50 60 pF1KE3 MWPPDPDPDPDPEPAGGSRPGPAVPGLRALLPARAFLCSLKGRLLLAESGLSFITFICYV : :... .::: : :: :: .: .:..: :::.. XP_016 MLSARDRRDRHPEEGVVAELQGFAVDKAFLTSHKGILLETELALTLIIFICFT 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 ASSASAFLTAPLLEFLLALYFLFADAMQLNDKWQGLCWPMMDFLRCVTAALIYFAISITA :: ::...: ::::...: ::: : : .... . :: .::::::.: .:....:..: XP_016 AS-ISAYMAAALLEFFITLAFLFLYATQYYQRFDRINWPCLDFLRCVSAIIIFLVVSFAA 60 70 80 90 100 110 130 140 150 160 170 pF1KE3 IAKYSDGASKAAGVFGFFATIVFATDFYLIF-NDVAKFLKQGDSADETTAHKTEEENSDS ... :::. :: :::.. . .:: : . :. ...: .::: XP_016 VTSR-DGAAIAAFVFGIILVSIFAYDAFKIYRTEMAPGASQGDQQ 120 130 140 150 180 pF1KE3 DSD >>XP_016876443 (OMIM: 607888) PREDICTED: CKLF-like MARVE (156 aa) initn: 204 init1: 204 opt: 336 Z-score: 337.0 bits: 68.7 E(85289): 5e-12 Smith-Waterman score: 336; 42.1% identity (73.6% similar) in 140 aa overlap (24-162:17-154) 10 20 30 40 50 60 pF1KE3 MWPPDPDPDPDPEPAGGSRPGPAVPGLRALLPARAFLCSLKGRLLLAESGLSFITFICYV : :... .::: : :: :: .: .:..: :::.. XP_016 MLSARDRRDRHPEEGVVAELQGFAVDKAFLTSHKGILLETELALTLIIFICFT 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 ASSASAFLTAPLLEFLLALYFLFADAMQLNDKWQGLCWPMMDFLRCVTAALIYFAISITA :: ::...: ::::...: ::: : : .... . :: .::::::.: .:....:..: XP_016 AS-ISAYMAAALLEFFITLAFLFLYATQYYQRFDRINWPCLDFLRCVSAIIIFLVVSFAA 60 70 80 90 100 110 130 140 150 160 170 pF1KE3 IAKYSDGASKAAGVFGFFATIVFATDFYLIF-NDVAKFLKQGDSADETTAHKTEEENSDS ... :::. :: :::.. . .:: : . :. ...: .::: XP_016 VTSR-DGAAIAAFVFGIILVSIFAYDAFKIYRTEMAPGASQGDQQ 120 130 140 150 180 pF1KE3 DSD >>NP_002659 (OMIM: 300112) proteolipid protein 2 [Homo s (152 aa) initn: 204 init1: 152 opt: 217 Z-score: 223.6 bits: 47.7 E(85289): 1e-05 Smith-Waterman score: 217; 31.8% identity (64.3% similar) in 129 aa overlap (23-151:8-133) 10 20 30 40 50 60 pF1KE3 MWPPDPDPDPDPEPAGGSRPGPAVPGLRALLPARAFLCSLKGRLLLAESGLSFITFICYV ..:: : : . :: ::.:: : .. .::. NP_002 MADSERLSAPGCWA--ACTNFSRTRKGILLFAEIILCLVILICFS 10 20 30 40 70 80 90 100 110 120 pF1KE3 ASSASAFLTAPLLEFLLALYFLFADAMQLNDKWQGLCWPMMDFLRCVTAALIYFAISITA ::. . . . ..:..:: :. . .:. : . :: ::.: . ::..:. ::.. NP_002 ASTPG-YSSLSVIEMILAAIFFVVYMCDLHTKIPFINWPWSDFFRTLIAAILYLITSIVV 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE3 IAKYSDGASKAAGVFGFFATIVFATDFYLIFNDVAKFLKQGDSADETTAHKTEEENSDSD ... .. .. .:::.:..:: .:. : :. : NP_002 LVERGNHSKIVAGVLGLIATCLFGYDAYVTFPVRQPRHTAAPTDPADGPV 110 120 130 140 150 pF1KE3 SD >>NP_001032365 (OMIM: 607888) CKLF-like MARVEL transmemb (125 aa) initn: 241 init1: 111 opt: 197 Z-score: 205.6 bits: 44.1 E(85289): 0.0001 Smith-Waterman score: 197; 37.4% identity (68.2% similar) in 107 aa overlap (24-130:17-121) 10 20 30 40 50 60 pF1KE3 MWPPDPDPDPDPEPAGGSRPGPAVPGLRALLPARAFLCSLKGRLLLAESGLSFITFICYV : :... .::: : :: :: .: .:..: :::.. NP_001 MLSARDRRDRHPEEGVVAELQGFAVDKAFLTSHKGILLETELALTLIIFICFT 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 ASSASAFLTAPLLEFLLALYFLFADAMQLNDKWQGLCWPMMDFLRCVTAALIYFAISITA :: ::...: ::::...: ::: : : .... . :: . : ... . : :..: NP_001 AS-ISAYMAAALLEFFITLAFLFLYATQYYQRFDRINWPCLVFGIILVSIFAYDAFKIYR 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 IAKYSDGASKAAGVFGFFATIVFATDFYLIFNDVAKFLKQGDSADETTAHKTEEENSDSD .... :::. NP_001 -TEMAPGASQGDQQ 120 >>NP_001275675 (OMIM: 607888) CKLF-like MARVEL transmemb (223 aa) initn: 270 init1: 107 opt: 184 Z-score: 189.9 bits: 42.0 E(85289): 0.00077 Smith-Waterman score: 184; 42.3% identity (70.5% similar) in 78 aa overlap (24-101:17-93) 10 20 30 40 50 60 pF1KE3 MWPPDPDPDPDPEPAGGSRPGPAVPGLRALLPARAFLCSLKGRLLLAESGLSFITFICYV : :... .::: : :: :: .: .:..: :::.. NP_001 MLSARDRRDRHPEEGVVAELQGFAVDKAFLTSHKGILLETELALTLIIFICFT 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 ASSASAFLTAPLLEFLLALYFLFADAMQLNDKWQGLCWPMMDFLRCVTAALIYFAISITA :: ::...: ::::...: ::: : : .... . :: . NP_001 AS-ISAYMAAALLEFFITLAFLFLYATQYYQRFDRINWPCLLQGHGQSGGPHPLDLLSHS 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 IAKYSDGASKAAGVFGFFATIVFATDFYLIFNDVAKFLKQGDSADETTAHKTEEENSDSD NP_001 AKVQPQPWPGLTPPGWHTPAAVPWVPAPAPGFWSWLLWFICFHSLGSSDFLRCVSAIIIF 120 130 140 150 160 170 182 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 17:04:44 2016 done: Mon Nov 7 17:04:45 2016 Total Scan time: 5.920 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]