FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4123, 511 aa 1>>>pF1KE4123 511 - 511 aa - 511 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7971+/-0.000432; mu= 15.9166+/- 0.027 mean_var=108.4258+/-22.188, 0's: 0 Z-trim(113.4): 192 B-trim: 186 in 1/50 Lambda= 0.123171 statistics sampled from 22357 (22764) to 22357 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.627), E-opt: 0.2 (0.267), width: 16 Scan time: 9.640 The best scores are: opt bits E(85289) NP_005540 (OMIM: 602420) potassium voltage-gated c ( 511) 3377 611.6 1.8e-174 NP_000208 (OMIM: 160120,176260) potassium voltage- ( 495) 1951 358.2 3.3e-98 XP_011539702 (OMIM: 176262,616366) PREDICTED: pota ( 499) 1940 356.2 1.3e-97 XP_011539699 (OMIM: 176262,616366) PREDICTED: pota ( 499) 1940 356.2 1.3e-97 XP_016856702 (OMIM: 176262,616366) PREDICTED: pota ( 499) 1940 356.2 1.3e-97 XP_011539701 (OMIM: 176262,616366) PREDICTED: pota ( 499) 1940 356.2 1.3e-97 XP_011539700 (OMIM: 176262,616366) PREDICTED: pota ( 499) 1940 356.2 1.3e-97 XP_011539698 (OMIM: 176262,616366) PREDICTED: pota ( 499) 1940 356.2 1.3e-97 NP_004965 (OMIM: 176262,616366) potassium voltage- ( 499) 1940 356.2 1.3e-97 NP_002223 (OMIM: 176263) potassium voltage-gated c ( 575) 1927 354.0 7.1e-97 NP_001191198 (OMIM: 176262,616366) potassium volta ( 356) 1189 222.6 1.5e-57 NP_002224 (OMIM: 176266) potassium voltage-gated c ( 653) 1120 210.6 1.1e-53 NP_114092 (OMIM: 176268) potassium voltage-gated c ( 456) 1081 203.5 1.1e-51 NP_002225 (OMIM: 176267,612240) potassium voltage- ( 613) 838 160.5 1.3e-38 XP_016874760 (OMIM: 176257) PREDICTED: potassium v ( 529) 824 157.9 6.7e-38 XP_016874761 (OMIM: 176257) PREDICTED: potassium v ( 529) 824 157.9 6.7e-38 XP_011519257 (OMIM: 176257) PREDICTED: potassium v ( 529) 824 157.9 6.7e-38 XP_016874759 (OMIM: 176257) PREDICTED: potassium v ( 529) 824 157.9 6.7e-38 XP_005253743 (OMIM: 176257) PREDICTED: potassium v ( 529) 824 157.9 6.7e-38 NP_002226 (OMIM: 176257) potassium voltage-gated c ( 529) 824 157.9 6.7e-38 XP_011527101 (OMIM: 600397,616056) PREDICTED: pota ( 858) 738 142.8 3.8e-33 XP_006723847 (OMIM: 600397,616056) PREDICTED: pota ( 858) 738 142.8 3.8e-33 NP_004966 (OMIM: 600397,616056) potassium voltage- ( 858) 738 142.8 3.8e-33 NP_004761 (OMIM: 607738) potassium voltage-gated c ( 911) 737 142.7 4.4e-33 NP_001309728 (OMIM: 602905) potassium voltage-gate ( 526) 687 133.6 1.4e-30 NP_002242 (OMIM: 602905) potassium voltage-gated c ( 526) 687 133.6 1.4e-30 XP_016883335 (OMIM: 602905) PREDICTED: potassium v ( 527) 687 133.6 1.4e-30 XP_011542212 (OMIM: 300281) PREDICTED: potassium v ( 647) 676 131.7 6.4e-30 NP_004970 (OMIM: 300281) potassium voltage-gated c ( 647) 676 131.7 6.4e-30 NP_715624 (OMIM: 176256) potassium voltage-gated c ( 558) 662 129.2 3.2e-29 XP_005268912 (OMIM: 176256) PREDICTED: potassium v ( 574) 662 129.2 3.3e-29 NP_001247428 (OMIM: 176256) potassium voltage-gate ( 583) 662 129.2 3.3e-29 XP_006719446 (OMIM: 176256) PREDICTED: potassium v ( 612) 662 129.2 3.4e-29 XP_016874771 (OMIM: 176256) PREDICTED: potassium v ( 612) 662 129.2 3.4e-29 XP_006719448 (OMIM: 176256) PREDICTED: potassium v ( 612) 662 129.2 3.4e-29 XP_006719447 (OMIM: 176256) PREDICTED: potassium v ( 612) 662 129.2 3.4e-29 XP_006719445 (OMIM: 176256) PREDICTED: potassium v ( 613) 662 129.2 3.4e-29 NP_631874 (OMIM: 176256) potassium voltage-gated c ( 613) 662 129.2 3.4e-29 NP_001247426 (OMIM: 176256) potassium voltage-gate ( 618) 662 129.2 3.5e-29 NP_001247427 (OMIM: 176256) potassium voltage-gate ( 629) 662 129.2 3.5e-29 NP_631875 (OMIM: 176256) potassium voltage-gated c ( 638) 662 129.2 3.5e-29 XP_016869470 (OMIM: 607738) PREDICTED: potassium v ( 666) 659 128.7 5.3e-29 XP_016869471 (OMIM: 607738) PREDICTED: potassium v ( 666) 659 128.7 5.3e-29 XP_006710694 (OMIM: 605411,607346,616399) PREDICTE ( 510) 654 127.7 8.1e-29 XP_006710693 (OMIM: 605411,607346,616399) PREDICTE ( 636) 654 127.8 9.5e-29 NP_751948 (OMIM: 605411,607346,616399) potassium v ( 636) 654 127.8 9.5e-29 XP_006710692 (OMIM: 605411,607346,616399) PREDICTE ( 655) 654 127.8 9.7e-29 XP_016856733 (OMIM: 605411,607346,616399) PREDICTE ( 655) 654 127.8 9.7e-29 NP_004971 (OMIM: 605411,607346,616399) potassium v ( 655) 654 127.8 9.7e-29 XP_005270908 (OMIM: 605411,607346,616399) PREDICTE ( 655) 654 127.8 9.7e-29 >>NP_005540 (OMIM: 602420) potassium voltage-gated chann (511 aa) initn: 3377 init1: 3377 opt: 3377 Z-score: 3253.4 bits: 611.6 E(85289): 1.8e-174 Smith-Waterman score: 3377; 100.0% identity (100.0% similar) in 511 aa overlap (1-511:1-511) 10 20 30 40 50 60 pF1KE4 MDVCGWKEMEVALVNFDNSDEIQEEPGYATDFDSTSPKGRPGGSSFSNGKILISESTNHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MDVCGWKEMEVALVNFDNSDEIQEEPGYATDFDSTSPKGRPGGSSFSNGKILISESTNHE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 TAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGLRFETQLRTLSQFPETLLGDREKRMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGLRFETQLRTLSQFPETLLGDREKRMQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 FFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDIFADEISFYELGSEAMDQFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 FFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDIFADEISFYELGSEAMDQFR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 EDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 EDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 FREDRELKVVRDPNLNMSKTVLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 FREDRELKVVRDPNLNMSKTVLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 RNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 RNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 LQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 TVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQNIPGEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQNIPGEI 430 440 450 460 470 480 490 500 510 pF1KE4 ERILNSVGSRMGSTDSLNKTNGGCSTEKSRK ::::::::::::::::::::::::::::::: NP_005 ERILNSVGSRMGSTDSLNKTNGGCSTEKSRK 490 500 510 >>NP_000208 (OMIM: 160120,176260) potassium voltage-gate (495 aa) initn: 1945 init1: 1592 opt: 1951 Z-score: 1884.1 bits: 358.2 E(85289): 3.3e-98 Smith-Waterman score: 1951; 69.5% identity (88.7% similar) in 416 aa overlap (64-476:13-427) 40 50 60 70 80 90 pF1KE4 STSPKGRPGGSSFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLN--EGNQRVIIN : :: : :. . . : .::.:: NP_000 MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVIN 10 20 30 40 100 110 120 130 140 150 pF1KE4 IAGLRFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKI :.::::::::.::.:::.::::. .:::..:: .::::::::::::::.:::::::::.. NP_000 ISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRL 50 60 70 80 90 100 160 170 180 190 200 210 pF1KE4 RRPANVPIDIFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPES :::.:::.:.:..::.::::: :::..:::::::::. : :: .. .:: ::::::::: NP_000 RRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPES 110 120 130 140 150 160 220 230 240 250 260 270 pF1KE4 SSAARAVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPNLNMSKTVLSQTMFTDPF :. ::..:.:::.:..:::.:::::::::...:... . .. . .. ....::::: NP_000 SGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVH-RIDNTTVIYNSNIFTDPF 170 180 190 200 210 220 280 290 300 310 320 330 pF1KE4 FMVESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELV-QETEPS :.::. ::.::.::::.:: .::::::::.::::.:::..::::: :: ::.. :: . . NP_000 FIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQK 230 240 250 260 270 280 340 350 360 370 380 390 pF1KE4 AQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFS ..: ::::::.:::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFS 290 300 310 320 330 340 400 410 420 430 440 450 pF1KE4 SAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIA :::::::..: :::::::::.::::::.::::::::: :.: ::::::.::::::::::: NP_000 SAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIA 350 360 370 380 390 400 460 470 480 490 500 510 pF1KE4 LPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLNKTNGGCSTEKSR :::::::::::::::::::.::. .. NP_000 LPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTMSKSEYMEIEEDM 410 420 430 440 450 460 >>XP_011539702 (OMIM: 176262,616366) PREDICTED: potassiu (499 aa) initn: 1943 init1: 835 opt: 1940 Z-score: 1873.5 bits: 356.2 E(85289): 1.3e-97 Smith-Waterman score: 1940; 66.7% identity (83.1% similar) in 450 aa overlap (66-509:15-456) 40 50 60 70 80 90 pF1KE4 SPKGRPGGSSFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGL ::: : :: . .: .::.:::.:: XP_011 MTVATGDPADEAAALPGHPQDTYDPE--ADHECCERVVINISGL 10 20 30 40 100 110 120 130 140 150 pF1KE4 RFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPA ::::::.::.::::::::: .:::..:: .::::::::::::::.:::::::::..:::. XP_011 RFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPV 50 60 70 80 90 100 160 170 180 190 200 210 pF1KE4 NVPIDIFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAA :::.:::..:: ::::: :::..::::::.::. : :: :...:: ::::::::::. : XP_011 NVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPA 110 120 130 140 150 160 220 230 240 250 260 270 pF1KE4 RAVAVVSVLVVVISITIFCLETLPEFREDRE----LKVVRDPNLNMSKTVLSQTMFTDPF : .:.:::.:..:::. ::::::: ::.. : :. : . ..: ::::: XP_011 RIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPF 170 180 190 200 210 220 280 290 300 310 320 330 pF1KE4 FMVESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPS- :.::. ::.::.::...:: .::::. :: ::::::::..::::: :: :::... : . XP_011 FIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQ 230 240 250 260 270 280 340 350 360 370 380 pF1KE4 -AQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILF .:: :::::::.::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILF 290 300 310 320 330 340 390 400 410 420 430 440 pF1KE4 SSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTI ::::::::.:: ::.: ::::.::::::.::::::::: ::: ::::::.:::::::::: XP_011 SSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTI 350 360 370 380 390 400 450 460 470 480 490 500 pF1KE4 ALPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLNKTNGGCSTEKS ::::::::::::::::::::.::. . . . .. :. .:.:. .. . :: XP_011 ALPVPVIVSNFNYFYHRETEGEEQA------QYLQVTSCPKIPSSPDLKKSRSASTISKS 410 420 430 440 450 510 pF1KE4 RK XP_011 DYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV 460 470 480 490 >>XP_011539699 (OMIM: 176262,616366) PREDICTED: potassiu (499 aa) initn: 1943 init1: 835 opt: 1940 Z-score: 1873.5 bits: 356.2 E(85289): 1.3e-97 Smith-Waterman score: 1940; 66.7% identity (83.1% similar) in 450 aa overlap (66-509:15-456) 40 50 60 70 80 90 pF1KE4 SPKGRPGGSSFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGL ::: : :: . .: .::.:::.:: XP_011 MTVATGDPADEAAALPGHPQDTYDPE--ADHECCERVVINISGL 10 20 30 40 100 110 120 130 140 150 pF1KE4 RFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPA ::::::.::.::::::::: .:::..:: .::::::::::::::.:::::::::..:::. XP_011 RFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPV 50 60 70 80 90 100 160 170 180 190 200 210 pF1KE4 NVPIDIFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAA :::.:::..:: ::::: :::..::::::.::. : :: :...:: ::::::::::. : XP_011 NVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPA 110 120 130 140 150 160 220 230 240 250 260 270 pF1KE4 RAVAVVSVLVVVISITIFCLETLPEFREDRE----LKVVRDPNLNMSKTVLSQTMFTDPF : .:.:::.:..:::. ::::::: ::.. : :. : . ..: ::::: XP_011 RIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPF 170 180 190 200 210 220 280 290 300 310 320 330 pF1KE4 FMVESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPS- :.::. ::.::.::...:: .::::. :: ::::::::..::::: :: :::... : . XP_011 FIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQ 230 240 250 260 270 280 340 350 360 370 380 pF1KE4 -AQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILF .:: :::::::.::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILF 290 300 310 320 330 340 390 400 410 420 430 440 pF1KE4 SSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTI ::::::::.:: ::.: ::::.::::::.::::::::: ::: ::::::.:::::::::: XP_011 SSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTI 350 360 370 380 390 400 450 460 470 480 490 500 pF1KE4 ALPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLNKTNGGCSTEKS ::::::::::::::::::::.::. . . . .. :. .:.:. .. . :: XP_011 ALPVPVIVSNFNYFYHRETEGEEQA------QYLQVTSCPKIPSSPDLKKSRSASTISKS 410 420 430 440 450 510 pF1KE4 RK XP_011 DYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV 460 470 480 490 >>XP_016856702 (OMIM: 176262,616366) PREDICTED: potassiu (499 aa) initn: 1943 init1: 835 opt: 1940 Z-score: 1873.5 bits: 356.2 E(85289): 1.3e-97 Smith-Waterman score: 1940; 66.7% identity (83.1% similar) in 450 aa overlap (66-509:15-456) 40 50 60 70 80 90 pF1KE4 SPKGRPGGSSFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGL ::: : :: . .: .::.:::.:: XP_016 MTVATGDPADEAAALPGHPQDTYDPE--ADHECCERVVINISGL 10 20 30 40 100 110 120 130 140 150 pF1KE4 RFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPA ::::::.::.::::::::: .:::..:: .::::::::::::::.:::::::::..:::. XP_016 RFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPV 50 60 70 80 90 100 160 170 180 190 200 210 pF1KE4 NVPIDIFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAA :::.:::..:: ::::: :::..::::::.::. : :: :...:: ::::::::::. : XP_016 NVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPA 110 120 130 140 150 160 220 230 240 250 260 270 pF1KE4 RAVAVVSVLVVVISITIFCLETLPEFREDRE----LKVVRDPNLNMSKTVLSQTMFTDPF : .:.:::.:..:::. ::::::: ::.. : :. : . ..: ::::: XP_016 RIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPF 170 180 190 200 210 220 280 290 300 310 320 330 pF1KE4 FMVESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPS- :.::. ::.::.::...:: .::::. :: ::::::::..::::: :: :::... : . XP_016 FIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQ 230 240 250 260 270 280 340 350 360 370 380 pF1KE4 -AQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILF .:: :::::::.::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILF 290 300 310 320 330 340 390 400 410 420 430 440 pF1KE4 SSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTI ::::::::.:: ::.: ::::.::::::.::::::::: ::: ::::::.:::::::::: XP_016 SSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTI 350 360 370 380 390 400 450 460 470 480 490 500 pF1KE4 ALPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLNKTNGGCSTEKS ::::::::::::::::::::.::. . . . .. :. .:.:. .. . :: XP_016 ALPVPVIVSNFNYFYHRETEGEEQA------QYLQVTSCPKIPSSPDLKKSRSASTISKS 410 420 430 440 450 510 pF1KE4 RK XP_016 DYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV 460 470 480 490 >>XP_011539701 (OMIM: 176262,616366) PREDICTED: potassiu (499 aa) initn: 1943 init1: 835 opt: 1940 Z-score: 1873.5 bits: 356.2 E(85289): 1.3e-97 Smith-Waterman score: 1940; 66.7% identity (83.1% similar) in 450 aa overlap (66-509:15-456) 40 50 60 70 80 90 pF1KE4 SPKGRPGGSSFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGL ::: : :: . .: .::.:::.:: XP_011 MTVATGDPADEAAALPGHPQDTYDPE--ADHECCERVVINISGL 10 20 30 40 100 110 120 130 140 150 pF1KE4 RFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPA ::::::.::.::::::::: .:::..:: .::::::::::::::.:::::::::..:::. XP_011 RFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPV 50 60 70 80 90 100 160 170 180 190 200 210 pF1KE4 NVPIDIFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAA :::.:::..:: ::::: :::..::::::.::. : :: :...:: ::::::::::. : XP_011 NVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPA 110 120 130 140 150 160 220 230 240 250 260 270 pF1KE4 RAVAVVSVLVVVISITIFCLETLPEFREDRE----LKVVRDPNLNMSKTVLSQTMFTDPF : .:.:::.:..:::. ::::::: ::.. : :. : . ..: ::::: XP_011 RIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPF 170 180 190 200 210 220 280 290 300 310 320 330 pF1KE4 FMVESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPS- :.::. ::.::.::...:: .::::. :: ::::::::..::::: :: :::... : . XP_011 FIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQ 230 240 250 260 270 280 340 350 360 370 380 pF1KE4 -AQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILF .:: :::::::.::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILF 290 300 310 320 330 340 390 400 410 420 430 440 pF1KE4 SSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTI ::::::::.:: ::.: ::::.::::::.::::::::: ::: ::::::.:::::::::: XP_011 SSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTI 350 360 370 380 390 400 450 460 470 480 490 500 pF1KE4 ALPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLNKTNGGCSTEKS ::::::::::::::::::::.::. . . . .. :. .:.:. .. . :: XP_011 ALPVPVIVSNFNYFYHRETEGEEQA------QYLQVTSCPKIPSSPDLKKSRSASTISKS 410 420 430 440 450 510 pF1KE4 RK XP_011 DYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV 460 470 480 490 >>XP_011539700 (OMIM: 176262,616366) PREDICTED: potassiu (499 aa) initn: 1943 init1: 835 opt: 1940 Z-score: 1873.5 bits: 356.2 E(85289): 1.3e-97 Smith-Waterman score: 1940; 66.7% identity (83.1% similar) in 450 aa overlap (66-509:15-456) 40 50 60 70 80 90 pF1KE4 SPKGRPGGSSFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGL ::: : :: . .: .::.:::.:: XP_011 MTVATGDPADEAAALPGHPQDTYDPE--ADHECCERVVINISGL 10 20 30 40 100 110 120 130 140 150 pF1KE4 RFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPA ::::::.::.::::::::: .:::..:: .::::::::::::::.:::::::::..:::. XP_011 RFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPV 50 60 70 80 90 100 160 170 180 190 200 210 pF1KE4 NVPIDIFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAA :::.:::..:: ::::: :::..::::::.::. : :: :...:: ::::::::::. : XP_011 NVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPA 110 120 130 140 150 160 220 230 240 250 260 270 pF1KE4 RAVAVVSVLVVVISITIFCLETLPEFREDRE----LKVVRDPNLNMSKTVLSQTMFTDPF : .:.:::.:..:::. ::::::: ::.. : :. : . ..: ::::: XP_011 RIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPF 170 180 190 200 210 220 280 290 300 310 320 330 pF1KE4 FMVESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPS- :.::. ::.::.::...:: .::::. :: ::::::::..::::: :: :::... : . XP_011 FIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQ 230 240 250 260 270 280 340 350 360 370 380 pF1KE4 -AQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILF .:: :::::::.::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILF 290 300 310 320 330 340 390 400 410 420 430 440 pF1KE4 SSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTI ::::::::.:: ::.: ::::.::::::.::::::::: ::: ::::::.:::::::::: XP_011 SSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTI 350 360 370 380 390 400 450 460 470 480 490 500 pF1KE4 ALPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLNKTNGGCSTEKS ::::::::::::::::::::.::. . . . .. :. .:.:. .. . :: XP_011 ALPVPVIVSNFNYFYHRETEGEEQA------QYLQVTSCPKIPSSPDLKKSRSASTISKS 410 420 430 440 450 510 pF1KE4 RK XP_011 DYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV 460 470 480 490 >>XP_011539698 (OMIM: 176262,616366) PREDICTED: potassiu (499 aa) initn: 1943 init1: 835 opt: 1940 Z-score: 1873.5 bits: 356.2 E(85289): 1.3e-97 Smith-Waterman score: 1940; 66.7% identity (83.1% similar) in 450 aa overlap (66-509:15-456) 40 50 60 70 80 90 pF1KE4 SPKGRPGGSSFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGL ::: : :: . .: .::.:::.:: XP_011 MTVATGDPADEAAALPGHPQDTYDPE--ADHECCERVVINISGL 10 20 30 40 100 110 120 130 140 150 pF1KE4 RFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPA ::::::.::.::::::::: .:::..:: .::::::::::::::.:::::::::..:::. XP_011 RFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPV 50 60 70 80 90 100 160 170 180 190 200 210 pF1KE4 NVPIDIFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAA :::.:::..:: ::::: :::..::::::.::. : :: :...:: ::::::::::. : XP_011 NVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPA 110 120 130 140 150 160 220 230 240 250 260 270 pF1KE4 RAVAVVSVLVVVISITIFCLETLPEFREDRE----LKVVRDPNLNMSKTVLSQTMFTDPF : .:.:::.:..:::. ::::::: ::.. : :. : . ..: ::::: XP_011 RIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPF 170 180 190 200 210 220 280 290 300 310 320 330 pF1KE4 FMVESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPS- :.::. ::.::.::...:: .::::. :: ::::::::..::::: :: :::... : . XP_011 FIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQ 230 240 250 260 270 280 340 350 360 370 380 pF1KE4 -AQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILF .:: :::::::.::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILF 290 300 310 320 330 340 390 400 410 420 430 440 pF1KE4 SSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTI ::::::::.:: ::.: ::::.::::::.::::::::: ::: ::::::.:::::::::: XP_011 SSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTI 350 360 370 380 390 400 450 460 470 480 490 500 pF1KE4 ALPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLNKTNGGCSTEKS ::::::::::::::::::::.::. . . . .. :. .:.:. .. . :: XP_011 ALPVPVIVSNFNYFYHRETEGEEQA------QYLQVTSCPKIPSSPDLKKSRSASTISKS 410 420 430 440 450 510 pF1KE4 RK XP_011 DYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV 460 470 480 490 >>NP_004965 (OMIM: 176262,616366) potassium voltage-gate (499 aa) initn: 1943 init1: 835 opt: 1940 Z-score: 1873.5 bits: 356.2 E(85289): 1.3e-97 Smith-Waterman score: 1940; 66.7% identity (83.1% similar) in 450 aa overlap (66-509:15-456) 40 50 60 70 80 90 pF1KE4 SPKGRPGGSSFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGL ::: : :: . .: .::.:::.:: NP_004 MTVATGDPADEAAALPGHPQDTYDPE--ADHECCERVVINISGL 10 20 30 40 100 110 120 130 140 150 pF1KE4 RFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPA ::::::.::.::::::::: .:::..:: .::::::::::::::.:::::::::..:::. NP_004 RFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPV 50 60 70 80 90 100 160 170 180 190 200 210 pF1KE4 NVPIDIFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAA :::.:::..:: ::::: :::..::::::.::. : :: :...:: ::::::::::. : NP_004 NVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPA 110 120 130 140 150 160 220 230 240 250 260 270 pF1KE4 RAVAVVSVLVVVISITIFCLETLPEFREDRE----LKVVRDPNLNMSKTVLSQTMFTDPF : .:.:::.:..:::. ::::::: ::.. : :. : . ..: ::::: NP_004 RIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPF 170 180 190 200 210 220 280 290 300 310 320 330 pF1KE4 FMVESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPS- :.::. ::.::.::...:: .::::. :: ::::::::..::::: :: :::... : . NP_004 FIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQ 230 240 250 260 270 280 340 350 360 370 380 pF1KE4 -AQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILF .:: :::::::.::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILF 290 300 310 320 330 340 390 400 410 420 430 440 pF1KE4 SSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTI ::::::::.:: ::.: ::::.::::::.::::::::: ::: ::::::.:::::::::: NP_004 SSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTI 350 360 370 380 390 400 450 460 470 480 490 500 pF1KE4 ALPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLNKTNGGCSTEKS ::::::::::::::::::::.::. . . . .. :. .:.:. .. . :: NP_004 ALPVPVIVSNFNYFYHRETEGEEQA------QYLQVTSCPKIPSSPDLKKSRSASTISKS 410 420 430 440 450 510 pF1KE4 RK NP_004 DYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV 460 470 480 490 >>NP_002223 (OMIM: 176263) potassium voltage-gated chann (575 aa) initn: 1924 init1: 836 opt: 1927 Z-score: 1860.2 bits: 354.0 E(85289): 7.1e-97 Smith-Waterman score: 1927; 70.8% identity (87.3% similar) in 408 aa overlap (73-473:90-496) 50 60 70 80 90 100 pF1KE4 GSSFSNGKILISESTNHETAFSKLPGDYADPPG-PEPVVLNEGNQRVIINIAGLRFETQL ::. : . ..::.:::.:::::::: NP_002 HLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQL 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE4 RTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDI .:: ::::::::: ..::..:: .::::::::::::::.:::::::::.::::.:::::: NP_002 KTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDI 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 FADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAARAVAVV :..:: ::.:: :::..:::::::... : :: :..:: ::::::::::. ::..:.: NP_002 FSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIV 180 190 200 210 220 230 230 240 250 260 270 pF1KE4 SVLVVVISITIFCLETLPEFREDRELKVVRDPNL------NMSKTVLSQTMFTDPFFMVE ::::..:::.:::::::::::.... . . . . : . . . :.::::.:: NP_002 SVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVE 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE4 STCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPSAQQNM . ::.::.:::..:: .::::. : :::::.:::..::::: :: :::. : . ..:: : NP_002 TLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELA-ERQGNGQQAM 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE4 SLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYF ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYF 360 370 380 390 400 410 400 410 420 430 440 450 pF1KE4 AEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPV ::.:.: : ::::::.:::::::::::::::: :.: ::::::.:::::::::::::::: NP_002 AEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPV 420 430 440 450 460 470 460 470 480 490 500 510 pF1KE4 IVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLNKTNGGCSTEKSRK ::::::::::::::.::. NP_002 IVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMN 480 490 500 510 520 530 511 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 17:02:14 2016 done: Mon Nov 7 17:02:15 2016 Total Scan time: 9.640 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]