FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4086, 449 aa 1>>>pF1KE4086 449 - 449 aa - 449 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.4343+/-0.000411; mu= 14.3093+/- 0.026 mean_var=181.4950+/-38.862, 0's: 0 Z-trim(117.3): 231 B-trim: 1307 in 1/51 Lambda= 0.095201 statistics sampled from 28855 (29178) to 28855 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.711), E-opt: 0.2 (0.342), width: 16 Scan time: 8.640 The best scores are: opt bits E(85289) NP_065091 (OMIM: 606124) tripartite motif-containi ( 452) 1348 197.8 5e-50 NP_660215 (OMIM: 607868) E3 ubiquitin-protein liga ( 468) 910 137.6 6.6e-32 XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 467) 906 137.1 9.6e-32 NP_003132 (OMIM: 109092) E3 ubiquitin-protein liga ( 475) 888 134.6 5.4e-31 XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 781 119.9 1.4e-26 XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 781 119.9 1.4e-26 NP_057186 (OMIM: 606123) E3 ubiquitin-protein liga ( 477) 781 119.9 1.4e-26 NP_001020111 (OMIM: 606123) E3 ubiquitin-protein l ( 477) 781 119.9 1.4e-26 XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 781 119.9 1.4e-26 XP_011542513 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 450) 702 109.1 2.6e-23 NP_742013 (OMIM: 605700) E3 ubiquitin-protein liga ( 488) 694 108.0 5.7e-23 XP_016873516 (OMIM: 606124) PREDICTED: tripartite ( 375) 607 95.9 1.9e-19 NP_067629 (OMIM: 605684) tripartite motif-containi ( 488) 565 90.3 1.2e-17 NP_001003827 (OMIM: 605684) tripartite motif-conta ( 488) 565 90.3 1.2e-17 NP_001128327 (OMIM: 606123) E3 ubiquitin-protein l ( 343) 502 81.4 4e-15 NP_060543 (OMIM: 613184) E3 ubiquitin-protein liga ( 485) 500 81.4 6e-15 XP_016856908 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 479 78.1 3e-14 XP_016856907 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 479 78.1 3e-14 NP_001268380 (OMIM: 612548) E3 ubiquitin-protein l ( 487) 450 74.5 7e-13 NP_835226 (OMIM: 612548) E3 ubiquitin-protein liga ( 487) 450 74.5 7e-13 NP_006065 (OMIM: 606559) E3 ubiquitin-protein liga ( 498) 450 74.5 7.1e-13 NP_001268379 (OMIM: 612548) E3 ubiquitin-protein l ( 486) 445 73.8 1.1e-12 XP_011514091 (OMIM: 612548) PREDICTED: E3 ubiquiti ( 486) 445 73.8 1.1e-12 NP_001291425 (OMIM: 613184) E3 ubiquitin-protein l ( 262) 441 72.9 1.1e-12 NP_001008275 (OMIM: 613288) tripartite motif-conta ( 477) 439 73.0 2e-12 NP_741983 (OMIM: 617007) tripartite motif-containi ( 493) 434 72.3 3.2e-12 NP_006501 (OMIM: 602165) zinc finger protein RFP [ ( 513) 429 71.6 5.4e-12 NP_067076 (OMIM: 605700) E3 ubiquitin-protein liga ( 518) 429 71.6 5.4e-12 NP_477514 (OMIM: 607564) tripartite motif-containi ( 488) 420 70.4 1.2e-11 NP_001003818 (OMIM: 607564) tripartite motif-conta ( 516) 420 70.4 1.3e-11 XP_005253240 (OMIM: 608487) PREDICTED: tripartite ( 493) 412 69.3 2.6e-11 NP_149023 (OMIM: 608487) tripartite motif-containi ( 493) 412 69.3 2.6e-11 XP_011542587 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 391) 410 68.9 2.8e-11 XP_016873951 (OMIM: 608487) PREDICTED: tripartite ( 300) 408 68.5 2.8e-11 NP_149084 (OMIM: 608487) tripartite motif-containi ( 326) 408 68.5 3e-11 XP_005253241 (OMIM: 608487) PREDICTED: tripartite ( 326) 408 68.5 3e-11 NP_149083 (OMIM: 608487) tripartite motif-containi ( 347) 408 68.5 3.1e-11 NP_439893 (OMIM: 605701) tripartite motif-containi ( 395) 401 67.6 6.6e-11 NP_006769 (OMIM: 605701) tripartite motif-containi ( 481) 401 67.8 7.4e-11 XP_011512567 (OMIM: 609316) PREDICTED: E3 ubiquiti ( 421) 397 67.1 1e-10 NP_008959 (OMIM: 609316) E3 ubiquitin-protein liga ( 425) 397 67.1 1e-10 XP_016873950 (OMIM: 608487) PREDICTED: tripartite ( 310) 393 66.4 1.2e-10 XP_011518728 (OMIM: 608487) PREDICTED: tripartite ( 310) 393 66.4 1.2e-10 XP_016873952 (OMIM: 608487) PREDICTED: tripartite ( 265) 391 66.0 1.3e-10 XP_006718421 (OMIM: 608487) PREDICTED: tripartite ( 265) 391 66.0 1.3e-10 XP_011518729 (OMIM: 608487) PREDICTED: tripartite ( 271) 381 64.7 3.5e-10 XP_011512566 (OMIM: 609316) PREDICTED: E3 ubiquiti ( 424) 381 64.9 4.6e-10 NP_569074 (OMIM: 605684) tripartite motif-containi ( 270) 378 64.3 4.6e-10 XP_011512527 (OMIM: 605701) PREDICTED: tripartite ( 413) 376 64.2 7.3e-10 XP_005273509 (OMIM: 617007) PREDICTED: tripartite ( 298) 373 63.6 7.9e-10 >>NP_065091 (OMIM: 606124) tripartite motif-containing p (452 aa) initn: 1314 init1: 794 opt: 1348 Z-score: 1019.1 bits: 197.8 E(85289): 5e-50 Smith-Waterman score: 1348; 46.9% identity (71.4% similar) in 448 aa overlap (1-445:1-448) 10 20 30 40 50 60 pF1KE4 MDSDDLQVFQNELICCICVNYFIDPVTIDCGHSFCRPCLCLCSEEGRAPMRCPSCRKTSE :.: :::::.:::: .:.:::::::::::::::::::. : .. ..: : :..: NP_065 MNSGILQVFQGELICPLCMNYFIDPVTIDCGHSFCRPCFYLNWQDIPFLVQCSECTKSTE 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 KPNFNTNLVLKKLSSLARQTRPQN-INSSDNICVLHEETKELFCEADKRLLCGPCSESPE . :..::. :::..::::.. ..: ...: :.:::..:::.:. ::: :: : : NP_065 QINLKTNIHLKKMASLARKVSLWLFLSSEEQMCGTHRETKKIFCEVDRSLLCLLCSSSQE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE4 HMAHSHSPIGWAAEECREKLIKEMDYLWEINQETRNNLNQETSTFHSLKDYVSVRKRIIT : : : :: ::::: ::::...:. ::: :.. ::: ::. . ::::..: . : NP_065 HRYHRHRPIEWAAEEHREKLLQKMQSLWEKACENHRNLNVETTRTRCWKDYVNLRLEAIR 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 IQYQKMPIFLDEEEQRHLQALEREAEELFQQLQDSQVRMTQHLERMKDMYRELWETCHMP .::::: : :::...:. :.....:.:..:. :...:....: .. ::.:: : :: : NP_065 AEYQKMPAFHHEEEKHNLEMLKKKGKEIFHRLHLSKAKMAHRMEILRGMYEELNEMCHKP 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE4 DVVLLQDVRNVSARTDLAQMQKPQPVNPELTSWCITGVLDMLNNFRVDSALSTEMIPCYI :: ::: .. :.. . .. :::.::::.. :::. : ::.::: .: : : NP_065 DVELLQAFGDILHRSESVLLHMPQPLNPELSAGPITGLRDRLNQFRVHITLHHEEANNDI 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE4 SLSEDVRYVIFGDDHLSAPTDPQGVDSFAVWGAQAFTSGKHYWEVDVTLSSNWILGVCRD : : .: . .: :: ..: :: .::.:.:::::.:::: : : :: .::: NP_065 FLYEILRSMCIGCDHQDVPYFTATPRSFLAWGVQTFTSGKYYWEVHVGDSWNWAFGVCNM 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE4 SRTA-DANFVIDSDERFFLISSKRSN-HYSLSTNSPPLIQYVQRPLGRVGVFLDYDNGSV : . : ::. .::.. ... . :: :.:: ..::. .: .:::.::: . .: NP_065 YRKEKNQNEKIDGKAGLFLLGCVKNDIQCSLFTTSPLMLQYIPKPTSRVGLFLDCEAKTV 370 380 390 400 410 420 420 430 440 pF1KE4 SFFDVSKGSLIYGFPPSSFSSPLRPFFCFGCT :: ::...:::: .: ::: ::::.:: NP_065 SFVDVNQSSLIYTIPNCSFSPPLRPIFCCIHF 430 440 450 >>NP_660215 (OMIM: 607868) E3 ubiquitin-protein ligase T (468 aa) initn: 815 init1: 301 opt: 910 Z-score: 693.9 bits: 137.6 E(85289): 6.6e-32 Smith-Waterman score: 910; 34.0% identity (61.3% similar) in 447 aa overlap (1-444:1-442) 10 20 30 40 50 pF1KE4 MDSDDLQV-FQNELICCICVNYFIDPVTIDCGHSFCRPCLCLCSEEGRAPMRCPSCRKTS : . ::.. .:.: : ::..:: ::: ::::.::: :. : . ..:. :: ::. : NP_660 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 EKPNFNTNLVLKKLSSLARQTRPQNINSSDNICVLHEETKELFCEADKRLLCGPCSESPE . :. : : :.. .::. .: . ...: :.: :: . ::::. : .: : NP_660 PQRNLRPNRPLAKMAEMARRLHPPS-PVPQGVCPAHREPLAAFCGDELRLLCAACERSGE 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 HMAHSHSPIGWAAEECREKLIKEMDYLWEINQETRNNLNQETSTFHSLKDYVSVRKRIIT : :: :. :::. . :: : ...: . :.. : : . .: ... . NP_660 HWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNVL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 IQYQKMPIFLDEEEQRHLQALEREAEELFQQLQDSQVRMTQHLERMKDMYRELWETCHMP ..... .: ::::. :: ::.: :.. .:... ... :. .. .. :: :..: NP_660 GEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQLP 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 DVVLLQDVRNVSARTDLAQMQKPQPVNPELTSWC-ITGVLDMLNNFRVDSALSTEMIPCY . ::::.... :.. ...: :. : :: . : . :... : :: : .:. . NP_660 ALGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTANPE 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 ISLSEDVRYVIFGDDHLSAPTDPQGVD-SFAVWGAQAFTSGKHYWEVDVTLSSNWILGVC . :::: : : :: . . : .:. : . : : . ::::.:::::.: ..: :::: NP_660 LILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVC 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 RDSRTADANFVIDSDERFFLISSKRSNHYSLSTNSPPLIQYVQRPLGRVGVFLDYDNGSV :.. . . ... . :... : . : :: . : :::.::::. : . NP_660 RENVNRKEKGELSAGNGFWILVFLGSYYNSSERALAPL----RDPPRRVGIFLDYEAGHL 360 370 380 390 400 410 420 430 440 pF1KE4 SFFDVSKGSLIYGFPPSSFSSPLRPFFCFGCT ::.... :::.. :: ::. :::.: NP_660 SFYSATDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ 420 430 440 450 460 >>XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquitin-pr (467 aa) initn: 557 init1: 259 opt: 906 Z-score: 690.9 bits: 137.1 E(85289): 9.6e-32 Smith-Waterman score: 906; 34.2% identity (61.5% similar) in 447 aa overlap (1-444:1-441) 10 20 30 40 50 pF1KE4 MDSDDLQV-FQNELICCICVNYFIDPVTIDCGHSFCRPCLCLCSEEGRAPMRCPSCRKTS : . ::.. .:.: : ::..:: ::: ::::.::: :. : . ..:. :: ::. : XP_016 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 EKPNFNTNLVLKKLSSLARQTRPQNINSSDNICVLHEETKELFCEADKRLLCGPCSESPE . :. : : :.. .::. .: . ...: :.: :: . ::::. : .: : XP_016 PQRNLRPNRPLAKMAEMARRLHPPS-PVPQGVCPAHREPLAAFCGDELRLLCAACERSGE 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 HMAHSHSPIGWAAEECREKLIKEMDYLWEINQETRNNLNQETSTFHSLKDYVSVRKRIIT : :: :. :::. . :: : ...: . :.. : : : ..: ... . XP_016 HWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETC-VLWQMVESQRQNVL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 IQYQKMPIFLDEEEQRHLQALEREAEELFQQLQDSQVRMTQHLERMKDMYRELWETCHMP ..... .: ::::. :: ::.: :.. .:... ... :. .. .. :: :..: XP_016 GEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQLP 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 DVVLLQDVRNVSARTDLAQMQKPQPVNPELTSWC-ITGVLDMLNNFRVDSALSTEMIPCY . ::::.... :.. ...: :. : :: . : . :... : :: : .:. . XP_016 ALGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTANPE 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 ISLSEDVRYVIFGDDHLSAPTDPQGVD-SFAVWGAQAFTSGKHYWEVDVTLSSNWILGVC . :::: : : :: . . : .:. : . : : . ::::.:::::.: ..: :::: XP_016 LILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVC 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 RDSRTADANFVIDSDERFFLISSKRSNHYSLSTNSPPLIQYVQRPLGRVGVFLDYDNGSV :.. . . ... . :... : . : :: . : :::.::::. : . XP_016 RENVNRKEKGELSAGNGFWILVFLGSYYNSSERALAPL----RDPPRRVGIFLDYEAGHL 360 370 380 390 400 410 420 430 440 pF1KE4 SFFDVSKGSLIYGFPPSSFSSPLRPFFCFGCT ::.... :::.. :: ::. :::.: XP_016 SFYSATDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ 420 430 440 450 460 >>NP_003132 (OMIM: 109092) E3 ubiquitin-protein ligase T (475 aa) initn: 656 init1: 276 opt: 888 Z-score: 677.4 bits: 134.6 E(85289): 5.4e-31 Smith-Waterman score: 888; 36.0% identity (63.1% similar) in 453 aa overlap (6-447:7-449) 10 20 30 40 50 pF1KE4 MDSDDLQVFQNELICCICVNYFIDPVTIDCGHSFCRPCLCLCSEEGRAPMRCPSCRKT- : .. .:. : ::.. :..::.:.::::::. :. .. : . :: ::. NP_003 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSV--CPVCRQRF 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 ---SEKPNFN-TNLV--LKKLSSLARQTRPQNINSSDNICVLHEETKELFCEADKRLLCG . .:: . .:.: ::..:. ::. ... . :..: : .:::: : . :: NP_003 LLKNLRPNRQLANMVNNLKEISQEARE------GTQGERCAVHGERLHLFCEKDGKALCW 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 PCSESPEHMAHSHSPIGWAAEECREKLIKEMDYLWEINQETRNNLNQETSTFHS-LKDYV :..: .: :. :. ::.: .::: . : . .:: ..:. : . .. : : NP_003 VCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRR-KQELAEKLEVEIAIKRADWKKTV 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 SVRKRIITIQYQKMPIFLDEEEQRHLQALEREAEELFQQLQDSQVRMTQHLERMKDMYRE ..: : .. .. :: :::::.:: ::.. .: .. : .......:. . .... : NP_003 ETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISE 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 LWETCHMPDVVLLQDVRNVSARTDLAQMQKPQPVNPELTSWC-ITGVLDMLNNFRVDSAL : . :: . :::.: : :.. ... . ..::: : : . :. :: . : .: NP_003 LDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITL 240 250 260 270 280 290 300 310 320 330 340 pF1KE4 STEMIPCYISLSEDVRYVIFGDDHLSAPTDPQGVDSFA-VWGAQAFTSGKHYWEVDVTLS . . .. :::: : : .:: . : : . . ::. : ::: : ::::::::::: . NP_003 DPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGK 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE4 SNWILGVCRDSRTADANFVIDSDERFFLISSKRSNHYSLSTNSPPLIQYVQRPLGRVGVF : ::::::: ..:...: :. : ...: .: : ..: : .::.: NP_003 EAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTY-PQTPLHLQVPPCQVGIF 360 370 380 390 400 410 410 420 430 440 pF1KE4 LDYDNGSVSFFDVS-KGSLIYGFPPSSFSSPLRPFFCFGCT :::. : :::.... .:::::.: .:..:::::: : NP_003 LDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQ 420 430 440 450 460 470 NP_003 GSTDY >>XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (477 aa) initn: 713 init1: 288 opt: 781 Z-score: 598.0 bits: 119.9 E(85289): 1.4e-26 Smith-Waterman score: 781; 31.9% identity (62.0% similar) in 461 aa overlap (9-447:10-459) 10 20 30 40 50 pF1KE4 MDSDDLQVFQNELICCICVNYFIDPVTIDCGHSFCRPCLCLCSEEGRAP---------M .:.: : ::..:: ::: :::.::: :. : :..:. . XP_011 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 RCPSCRKTSEKPNFNTNLVLKKLSSLARQTRPQNINSSDNICVLHEETKELFCEADKRLL :: ::. : . :. : .: :.. .:.: .: .....: .: :.: .:::. :. . XP_011 PCPECREMSPQRNLLPNRLLTKVAEMAQQ-HP-GLQKQD-LCQEHHEPLKLFCQKDQSPI 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 CGPCSESPEHMAHSHSPIGWAAEECREKLIKEMDYLWEINQETRNNLNQETSTFHSLKDY : : :: :: : : :.. . :: ..:.:: : .: : .: ... . XP_011 CVVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGK 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 VSVRKRIITIQYQKMPIFLDEEEQRHLQALEREAEELFQQLQDSQVRMTQHLERMKDMYR :. :.. :.....:: ..: ::::: ::::: : :: ..:..: . . .. . .. . XP_011 VKERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLL 180 190 200 210 220 230 240 250 260 270 280 pF1KE4 ELWETCHMPDVVLLQDVRNVSARTDLAQMQKPQ---PVNPELTSWC-ITGVLDMLNNFRV .: : . . .:::... .: . ...: :. :. :. . : . : ...: .: XP_011 QLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPR--TVCRVPGQIEVLRGFLE 240 250 260 270 280 290 290 300 310 320 330 pF1KE4 DSALSTEMIPCYISLSEDVRYVIFGDDHLSAPTDPQGV---DSFAVW----GAQAFTSGK : . .. :. : :. . .: :.: . .: : :... : ::.::. XP_011 DVVPDATSAYPYLLLYESRQRRYLG----SSP-EGSGFCSKDRFVAYPCAVGQTAFSSGR 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE4 HYWEVDVTLSSN--WILGVCRDSRTADANFVIDSDERFFLISSKRSNHYSLSTNSPPLIQ ::::: ...... : ::::::. . .. :.... .....: ::: : XP_011 HYWEVGMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKY-LSTFSALTPV 360 370 380 390 400 400 410 420 430 440 pF1KE4 YVQRPLGRVGVFLDYDNGSVSFFDVSKGSLIYGFPPSSFSSPLRPFFCFGCT ....: ...:.:::.. : :::..:: :: .. . ..: .::.::::.: XP_011 MLMEPPSHMGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVIS 410 420 430 440 450 460 XP_011 TVTMWVKG 470 >>XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (477 aa) initn: 713 init1: 288 opt: 781 Z-score: 598.0 bits: 119.9 E(85289): 1.4e-26 Smith-Waterman score: 781; 31.9% identity (62.0% similar) in 461 aa overlap (9-447:10-459) 10 20 30 40 50 pF1KE4 MDSDDLQVFQNELICCICVNYFIDPVTIDCGHSFCRPCLCLCSEEGRAP---------M .:.: : ::..:: ::: :::.::: :. : :..:. . XP_006 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 RCPSCRKTSEKPNFNTNLVLKKLSSLARQTRPQNINSSDNICVLHEETKELFCEADKRLL :: ::. : . :. : .: :.. .:.: .: .....: .: :.: .:::. :. . XP_006 PCPECREMSPQRNLLPNRLLTKVAEMAQQ-HP-GLQKQD-LCQEHHEPLKLFCQKDQSPI 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 CGPCSESPEHMAHSHSPIGWAAEECREKLIKEMDYLWEINQETRNNLNQETSTFHSLKDY : : :: :: : : :.. . :: ..:.:: : .: : .: ... . XP_006 CVVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGK 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 VSVRKRIITIQYQKMPIFLDEEEQRHLQALEREAEELFQQLQDSQVRMTQHLERMKDMYR :. :.. :.....:: ..: ::::: ::::: : :: ..:..: . . .. . .. . XP_006 VKERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLL 180 190 200 210 220 230 240 250 260 270 280 pF1KE4 ELWETCHMPDVVLLQDVRNVSARTDLAQMQKPQ---PVNPELTSWC-ITGVLDMLNNFRV .: : . . .:::... .: . ...: :. :. :. . : . : ...: .: XP_006 QLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPR--TVCRVPGQIEVLRGFLE 240 250 260 270 280 290 290 300 310 320 330 pF1KE4 DSALSTEMIPCYISLSEDVRYVIFGDDHLSAPTDPQGV---DSFAVW----GAQAFTSGK : . .. :. : :. . .: :.: . .: : :... : ::.::. XP_006 DVVPDATSAYPYLLLYESRQRRYLG----SSP-EGSGFCSKDRFVAYPCAVGQTAFSSGR 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE4 HYWEVDVTLSSN--WILGVCRDSRTADANFVIDSDERFFLISSKRSNHYSLSTNSPPLIQ ::::: ...... : ::::::. . .. :.... .....: ::: : XP_006 HYWEVGMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKY-LSTFSALTPV 360 370 380 390 400 400 410 420 430 440 pF1KE4 YVQRPLGRVGVFLDYDNGSVSFFDVSKGSLIYGFPPSSFSSPLRPFFCFGCT ....: ...:.:::.. : :::..:: :: .. . ..: .::.::::.: XP_006 MLMEPPSHMGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVIS 410 420 430 440 450 460 XP_006 TVTMWVKG 470 >>NP_057186 (OMIM: 606123) E3 ubiquitin-protein ligase T (477 aa) initn: 713 init1: 288 opt: 781 Z-score: 598.0 bits: 119.9 E(85289): 1.4e-26 Smith-Waterman score: 781; 31.9% identity (62.0% similar) in 461 aa overlap (9-447:10-459) 10 20 30 40 50 pF1KE4 MDSDDLQVFQNELICCICVNYFIDPVTIDCGHSFCRPCLCLCSEEGRAP---------M .:.: : ::..:: ::: :::.::: :. : :..:. . NP_057 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 RCPSCRKTSEKPNFNTNLVLKKLSSLARQTRPQNINSSDNICVLHEETKELFCEADKRLL :: ::. : . :. : .: :.. .:.: .: .....: .: :.: .:::. :. . NP_057 PCPECREMSPQRNLLPNRLLTKVAEMAQQ-HP-GLQKQD-LCQEHHEPLKLFCQKDQSPI 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 CGPCSESPEHMAHSHSPIGWAAEECREKLIKEMDYLWEINQETRNNLNQETSTFHSLKDY : : :: :: : : :.. . :: ..:.:: : .: : .: ... . NP_057 CVVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGK 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 VSVRKRIITIQYQKMPIFLDEEEQRHLQALEREAEELFQQLQDSQVRMTQHLERMKDMYR :. :.. :.....:: ..: ::::: ::::: : :: ..:..: . . .. . .. . NP_057 VKERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLL 180 190 200 210 220 230 240 250 260 270 280 pF1KE4 ELWETCHMPDVVLLQDVRNVSARTDLAQMQKPQ---PVNPELTSWC-ITGVLDMLNNFRV .: : . . .:::... .: . ...: :. :. :. . : . : ...: .: NP_057 QLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPR--TVCRVPGQIEVLRGFLE 240 250 260 270 280 290 290 300 310 320 330 pF1KE4 DSALSTEMIPCYISLSEDVRYVIFGDDHLSAPTDPQGV---DSFAVW----GAQAFTSGK : . .. :. : :. . .: :.: . .: : :... : ::.::. NP_057 DVVPDATSAYPYLLLYESRQRRYLG----SSP-EGSGFCSKDRFVAYPCAVGQTAFSSGR 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE4 HYWEVDVTLSSN--WILGVCRDSRTADANFVIDSDERFFLISSKRSNHYSLSTNSPPLIQ ::::: ...... : ::::::. . .. :.... .....: ::: : NP_057 HYWEVGMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKY-LSTFSALTPV 360 370 380 390 400 400 410 420 430 440 pF1KE4 YVQRPLGRVGVFLDYDNGSVSFFDVSKGSLIYGFPPSSFSSPLRPFFCFGCT ....: ...:.:::.. : :::..:: :: .. . ..: .::.::::.: NP_057 MLMEPPSHMGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVIS 410 420 430 440 450 460 NP_057 TVTMWVKG 470 >>NP_001020111 (OMIM: 606123) E3 ubiquitin-protein ligas (477 aa) initn: 713 init1: 288 opt: 781 Z-score: 598.0 bits: 119.9 E(85289): 1.4e-26 Smith-Waterman score: 781; 31.9% identity (62.0% similar) in 461 aa overlap (9-447:10-459) 10 20 30 40 50 pF1KE4 MDSDDLQVFQNELICCICVNYFIDPVTIDCGHSFCRPCLCLCSEEGRAP---------M .:.: : ::..:: ::: :::.::: :. : :..:. . NP_001 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 RCPSCRKTSEKPNFNTNLVLKKLSSLARQTRPQNINSSDNICVLHEETKELFCEADKRLL :: ::. : . :. : .: :.. .:.: .: .....: .: :.: .:::. :. . NP_001 PCPECREMSPQRNLLPNRLLTKVAEMAQQ-HP-GLQKQD-LCQEHHEPLKLFCQKDQSPI 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 CGPCSESPEHMAHSHSPIGWAAEECREKLIKEMDYLWEINQETRNNLNQETSTFHSLKDY : : :: :: : : :.. . :: ..:.:: : .: : .: ... . NP_001 CVVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGK 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 VSVRKRIITIQYQKMPIFLDEEEQRHLQALEREAEELFQQLQDSQVRMTQHLERMKDMYR :. :.. :.....:: ..: ::::: ::::: : :: ..:..: . . .. . .. . NP_001 VKERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLL 180 190 200 210 220 230 240 250 260 270 280 pF1KE4 ELWETCHMPDVVLLQDVRNVSARTDLAQMQKPQ---PVNPELTSWC-ITGVLDMLNNFRV .: : . . .:::... .: . ...: :. :. :. . : . : ...: .: NP_001 QLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPR--TVCRVPGQIEVLRGFLE 240 250 260 270 280 290 290 300 310 320 330 pF1KE4 DSALSTEMIPCYISLSEDVRYVIFGDDHLSAPTDPQGV---DSFAVW----GAQAFTSGK : . .. :. : :. . .: :.: . .: : :... : ::.::. NP_001 DVVPDATSAYPYLLLYESRQRRYLG----SSP-EGSGFCSKDRFVAYPCAVGQTAFSSGR 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE4 HYWEVDVTLSSN--WILGVCRDSRTADANFVIDSDERFFLISSKRSNHYSLSTNSPPLIQ ::::: ...... : ::::::. . .. :.... .....: ::: : NP_001 HYWEVGMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKY-LSTFSALTPV 360 370 380 390 400 400 410 420 430 440 pF1KE4 YVQRPLGRVGVFLDYDNGSVSFFDVSKGSLIYGFPPSSFSSPLRPFFCFGCT ....: ...:.:::.. : :::..:: :: .. . ..: .::.::::.: NP_001 MLMEPPSHMGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVIS 410 420 430 440 450 460 NP_001 TVTMWVKG 470 >>XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (477 aa) initn: 713 init1: 288 opt: 781 Z-score: 598.0 bits: 119.9 E(85289): 1.4e-26 Smith-Waterman score: 781; 31.9% identity (62.0% similar) in 461 aa overlap (9-447:10-459) 10 20 30 40 50 pF1KE4 MDSDDLQVFQNELICCICVNYFIDPVTIDCGHSFCRPCLCLCSEEGRAP---------M .:.: : ::..:: ::: :::.::: :. : :..:. . XP_011 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 RCPSCRKTSEKPNFNTNLVLKKLSSLARQTRPQNINSSDNICVLHEETKELFCEADKRLL :: ::. : . :. : .: :.. .:.: .: .....: .: :.: .:::. :. . XP_011 PCPECREMSPQRNLLPNRLLTKVAEMAQQ-HP-GLQKQD-LCQEHHEPLKLFCQKDQSPI 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 CGPCSESPEHMAHSHSPIGWAAEECREKLIKEMDYLWEINQETRNNLNQETSTFHSLKDY : : :: :: : : :.. . :: ..:.:: : .: : .: ... . XP_011 CVVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGK 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 VSVRKRIITIQYQKMPIFLDEEEQRHLQALEREAEELFQQLQDSQVRMTQHLERMKDMYR :. :.. :.....:: ..: ::::: ::::: : :: ..:..: . . .. . .. . XP_011 VKERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLL 180 190 200 210 220 230 240 250 260 270 280 pF1KE4 ELWETCHMPDVVLLQDVRNVSARTDLAQMQKPQ---PVNPELTSWC-ITGVLDMLNNFRV .: : . . .:::... .: . ...: :. :. :. . : . : ...: .: XP_011 QLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPR--TVCRVPGQIEVLRGFLE 240 250 260 270 280 290 290 300 310 320 330 pF1KE4 DSALSTEMIPCYISLSEDVRYVIFGDDHLSAPTDPQGV---DSFAVW----GAQAFTSGK : . .. :. : :. . .: :.: . .: : :... : ::.::. XP_011 DVVPDATSAYPYLLLYESRQRRYLG----SSP-EGSGFCSKDRFVAYPCAVGQTAFSSGR 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE4 HYWEVDVTLSSN--WILGVCRDSRTADANFVIDSDERFFLISSKRSNHYSLSTNSPPLIQ ::::: ...... : ::::::. . .. :.... .....: ::: : XP_011 HYWEVGMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKY-LSTFSALTPV 360 370 380 390 400 400 410 420 430 440 pF1KE4 YVQRPLGRVGVFLDYDNGSVSFFDVSKGSLIYGFPPSSFSSPLRPFFCFGCT ....: ...:.:::.. : :::..:: :: .. . ..: .::.::::.: XP_011 MLMEPPSHMGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVIS 410 420 430 440 450 460 XP_011 TVTMWVKG 470 >>XP_011542513 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (450 aa) initn: 657 init1: 288 opt: 702 Z-score: 539.6 bits: 109.1 E(85289): 2.6e-23 Smith-Waterman score: 702; 31.5% identity (61.9% similar) in 441 aa overlap (30-447:4-432) 10 20 30 40 50 pF1KE4 MDSDDLQVFQNELICCICVNYFIDPVTIDCGHSFCRPCLCLCSEEGRAP---------MR :::.::: :. : :..:. . XP_011 MTTCGHNFCRACIQLSWEKARGKKGRRKRKGSFP 10 20 30 60 70 80 90 100 110 pF1KE4 CPSCRKTSEKPNFNTNLVLKKLSSLARQTRPQNINSSDNICVLHEETKELFCEADKRLLC :: ::. : . :. : .: :.. .:.: .: .....: .: :.: .:::. :. .: XP_011 CPECREMSPQRNLLPNRLLTKVAEMAQQ-HP-GLQKQD-LCQEHHEPLKLFCQKDQSPIC 40 50 60 70 80 90 120 130 140 150 160 170 pF1KE4 GPCSESPEHMAHSHSPIGWAAEECREKLIKEMDYLWEINQETRNNLNQETSTFHSLKDYV : :: :: : : :.. . :: ..:.:: : .: : .: ... . : XP_011 VVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKV 100 110 120 130 140 150 180 190 200 210 220 230 pF1KE4 SVRKRIITIQYQKMPIFLDEEEQRHLQALEREAEELFQQLQDSQVRMTQHLERMKDMYRE . :.. :.....:: ..: ::::: ::::: : :: ..:..: . . .. . .. . . XP_011 KERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQ 160 170 180 190 200 210 240 250 260 270 280 pF1KE4 LWETCHMPDVVLLQDVRNVSARTDLAQMQKPQ---PVNPELTSWC-ITGVLDMLNNFRVD : : . . .:::... .: . ...: :. :. :. . : . : ...: .: : XP_011 LEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTV--CRVPGQIEVLRGFLED 220 230 240 250 260 290 300 310 320 330 pF1KE4 SAL-STEMIPCYISLSEDVRYVIFGDDHLSAPTDPQGV---DSFAVW----GAQAFTSGK . .: : :. : :. . .: :.: . .: : :... : ::.::. XP_011 VVPDATSAYP-YLLLYESRQRRYLG----SSP-EGSGFCSKDRFVAYPCAVGQTAFSSGR 270 280 290 300 310 320 340 350 360 370 380 390 pF1KE4 HYWEVDVTLSSN--WILGVCRDSRTADANFVIDSDERFFLISSKRSNHYSLSTNSPPLIQ ::::: ...... : ::::::. . .. :.... .....: ::: : XP_011 HYWEVGMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKY-LSTFSALTPV 330 340 350 360 370 380 400 410 420 430 440 pF1KE4 YVQRPLGRVGVFLDYDNGSVSFFDVSKGSLIYGFPPSSFSSPLRPFFCFGCT ....: ...:.:::.. : :::..:: :: .. . ..: .::.::::.: XP_011 MLMEPPSHMGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVIS 390 400 410 420 430 440 XP_011 TVTMWVKG 450 449 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 16:52:01 2016 done: Mon Nov 7 16:52:02 2016 Total Scan time: 8.640 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]