FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4220, 759 aa 1>>>pF1KE4220 759 - 759 aa - 759 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.4569+/-0.000338; mu= 16.4210+/- 0.021 mean_var=135.5056+/-28.025, 0's: 0 Z-trim(119.3): 187 B-trim: 804 in 1/58 Lambda= 0.110178 statistics sampled from 32943 (33155) to 32943 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.736), E-opt: 0.2 (0.389), width: 16 Scan time: 10.360 The best scores are: opt bits E(85289) NP_079334 (OMIM: 600986) tripartite motif-containi ( 759) 5215 840.9 0 XP_011508304 (OMIM: 600986) PREDICTED: tripartite ( 788) 5098 822.3 0 NP_001243530 (OMIM: 600986) tripartite motif-conta ( 746) 5086 820.3 0 XP_016857882 (OMIM: 600986) PREDICTED: tripartite ( 746) 5086 820.3 0 NP_001243528 (OMIM: 600986) tripartite motif-conta ( 736) 5076 818.8 0 NP_001269307 (OMIM: 600986) tripartite motif-conta ( 633) 4347 702.8 1.1e-201 NP_001269308 (OMIM: 600986) tripartite motif-conta ( 551) 3649 591.8 2.5e-168 NP_001243529 (OMIM: 600986) tripartite motif-conta ( 717) 2974 484.6 6.1e-136 XP_016865110 (OMIM: 609317) PREDICTED: E3 ubiquiti ( 745) 1972 325.4 5.5e-88 XP_016865111 (OMIM: 609317) PREDICTED: E3 ubiquiti ( 733) 1936 319.6 2.9e-86 NP_001287688 (OMIM: 609317) E3 ubiquitin-protein l ( 716) 1786 295.8 4.2e-79 NP_061170 (OMIM: 609317) E3 ubiquitin-protein liga ( 728) 1779 294.7 9.3e-79 XP_016865112 (OMIM: 609317) PREDICTED: E3 ubiquiti ( 529) 1558 259.4 2.8e-68 NP_001287681 (OMIM: 609317) E3 ubiquitin-protein l ( 573) 1500 250.2 1.8e-65 NP_001092094 (OMIM: 189960,300000,300552) E3 ubiqu ( 667) 591 105.8 6.1e-22 NP_001180206 (OMIM: 189960,300000,300552) E3 ubiqu ( 667) 591 105.8 6.1e-22 NP_150632 (OMIM: 189960,300000,300552) E3 ubiquiti ( 667) 591 105.8 6.1e-22 XP_016885025 (OMIM: 189960,300000,300552) PREDICTE ( 667) 591 105.8 6.1e-22 NP_000372 (OMIM: 189960,300000,300552) E3 ubiquiti ( 667) 591 105.8 6.1e-22 XP_016885029 (OMIM: 189960,300000,300552) PREDICTE ( 552) 584 104.6 1.2e-21 XP_016885031 (OMIM: 189960,300000,300552) PREDICTE ( 489) 514 93.4 2.4e-18 NP_001180208 (OMIM: 189960,300000,300552) E3 ubiqu ( 489) 514 93.4 2.4e-18 XP_016870672 (OMIM: 609829) PREDICTED: FSD1-like p ( 498) 400 75.3 6.8e-13 NP_001317668 (OMIM: 609829) FSD1-like protein isof ( 509) 399 75.2 7.7e-13 NP_001274121 (OMIM: 609829) FSD1-like protein isof ( 497) 397 74.8 9.5e-13 NP_001138785 (OMIM: 609829) FSD1-like protein isof ( 530) 396 74.7 1.1e-12 XP_011517380 (OMIM: 609829) PREDICTED: FSD1-like p ( 543) 396 74.7 1.1e-12 XP_005252311 (OMIM: 609829) PREDICTED: FSD1-like p ( 541) 395 74.6 1.3e-12 XP_011517379 (OMIM: 609829) PREDICTED: FSD1-like p ( 547) 395 74.6 1.3e-12 XP_016870671 (OMIM: 609829) PREDICTED: FSD1-like p ( 529) 393 74.2 1.5e-12 XP_011517381 (OMIM: 609829) PREDICTED: FSD1-like p ( 542) 393 74.2 1.6e-12 NP_001274120 (OMIM: 609829) FSD1-like protein isof ( 508) 392 74.1 1.7e-12 NP_077309 (OMIM: 609828) fibronectin type III and ( 496) 389 73.6 2.3e-12 NP_001317358 (OMIM: 609828) fibronectin type III a ( 437) 387 73.2 2.6e-12 XP_016870676 (OMIM: 609829) PREDICTED: FSD1-like p ( 317) 382 72.3 3.6e-12 XP_016870674 (OMIM: 609829) PREDICTED: FSD1-like p ( 362) 378 71.7 6.1e-12 NP_115977 (OMIM: 606131) E3 ubiquitin-protein liga ( 353) 363 69.3 3.2e-11 XP_016858048 (OMIM: 606131) PREDICTED: E3 ubiquiti ( 379) 363 69.3 3.3e-11 XP_011515919 (OMIM: 606469) PREDICTED: tripartite ( 426) 358 68.6 6.3e-11 XP_016869398 (OMIM: 606469) PREDICTED: tripartite ( 426) 358 68.6 6.3e-11 XP_011515918 (OMIM: 606469) PREDICTED: tripartite ( 452) 358 68.6 6.5e-11 NP_908974 (OMIM: 606469) tripartite motif-containi ( 452) 358 68.6 6.5e-11 XP_016869397 (OMIM: 606469) PREDICTED: tripartite ( 479) 358 68.6 6.8e-11 NP_912730 (OMIM: 606474) tripartite motif-containi ( 358) 356 68.2 6.9e-11 XP_011515917 (OMIM: 606469) PREDICTED: tripartite ( 540) 358 68.7 7.4e-11 NP_149047 (OMIM: 606469) tripartite motif-containi ( 540) 358 68.7 7.4e-11 XP_011515916 (OMIM: 606469) PREDICTED: tripartite ( 548) 358 68.7 7.5e-11 XP_011515915 (OMIM: 606469) PREDICTED: tripartite ( 548) 358 68.7 7.5e-11 NP_908973 (OMIM: 606469) tripartite motif-containi ( 548) 358 68.7 7.5e-11 XP_005251373 (OMIM: 606469) PREDICTED: tripartite ( 547) 356 68.4 9.3e-11 >>NP_079334 (OMIM: 600986) tripartite motif-containing p (759 aa) initn: 5215 init1: 5215 opt: 5215 Z-score: 4486.5 bits: 840.9 E(85289): 0 Smith-Waterman score: 5215; 100.0% identity (100.0% similar) in 759 aa overlap (1-759:1-759) 10 20 30 40 50 60 pF1KE4 MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 LGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 LHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 EATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 EATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 CQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEEAVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 CQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEEAVR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 HTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLLDGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 HTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLLDGS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 GLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 GLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 LTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 LTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRW 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 QRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDSRWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 QRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDSRWG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 ASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWACAVDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 ASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWACAVDP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 ASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTIGMGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 ASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTIGMGK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE4 ILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLECPLDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 ILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLECPLDC 670 680 690 700 710 720 730 740 750 pF1KE4 SGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD ::::::::::::::::::::::::::::::::::::::: NP_079 SGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD 730 740 750 >>XP_011508304 (OMIM: 600986) PREDICTED: tripartite moti (788 aa) initn: 5098 init1: 5098 opt: 5098 Z-score: 4385.7 bits: 822.3 E(85289): 0 Smith-Waterman score: 5147; 96.3% identity (96.3% similar) in 788 aa overlap (1-759:1-788) 10 20 30 pF1KE4 MAEGEDMQTFTSIMDALVRIS-----------------------------TSMKNMEKEL ::::::::::::::::::::: :::::::::: XP_011 MAEGEDMQTFTSIMDALVRISLCSGEREARDRGLGRSVNQPKAGALEKLQTSMKNMEKEL 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE4 LCPVCQEMYKQPLVLPCTHNVCQACAREVLGQQGYIGHGGDPSSEPTSPASTPSTRSPRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LCPVCQEMYKQPLVLPCTHNVCQACAREVLGQQGYIGHGGDPSSEPTSPASTPSTRSPRL 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE4 SRRTLPKPDRLDRLLKSGFGTYPGRKRGALHPQVIMFPCPACQGDVELGERGLAGLFRNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SRRTLPKPDRLDRLLKSGFGTYPGRKRGALHPQVIMFPCPACQGDVELGERGLAGLFRNL 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE4 TLERVVERYRQSVSVGGAILCQLCKPPPLEATKGCTECRATFCNECFKLFHPWGTQKAQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLERVVERYRQSVSVGGAILCQLCKPPPLEATKGCTECRATFCNECFKLFHPWGTQKAQH 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE4 EPTLPTLSFRPKGLMCPDHKEEVTHYCKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EPTLPTLSFRPKGLMCPDHKEEVTHYCKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALK 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE4 DKLTKSLTYILGNQDTVQTQICELEEAVRHTEVSGQQAKEEVSQLVRGLGAVLEEKRASL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DKLTKSLTYILGNQDTVQTQICELEEAVRHTEVSGQQAKEEVSQLVRGLGAVLEEKRASL 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE4 LQAIEECQQERLARLSAQIQEHRSLLDGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQAIEECQQERLARLSAQIQEHRSLLDGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIAR 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE4 ATEALQTFRPAASSSFRHCQLDVGREMKLLTELNFLRVPEAPVIDTQRTFAYDQIFLCWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ATEALQTFRPAASSSFRHCQLDVGREMKLLTELNFLRVPEAPVIDTQRTFAYDQIFLCWR 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE4 LPPHSPPAWHYTVEFRRTDVPAQPGPTRWQRREEVRGTSALLENPDTGSVYVLRVRGCNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPPHSPPAWHYTVEFRRTDVPAQPGPTRWQRREEVRGTSALLENPDTGSVYVLRVRGCNK 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE4 AGYGEYSEDVHLHTPPAPVLHFFLDSRWGASRERLAISKDQRAVRSVPGLPLLLAADRLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AGYGEYSEDVHLHTPPAPVLHFFLDSRWGASRERLAISKDQRAVRSVPGLPLLLAADRLL 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE4 TGCHLSVDVVLGDVAVTQGRSYWACAVDPASYLVKVGVGLESKLQESFQGAPDVISPRYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGCHLSVDVVLGDVAVTQGRSYWACAVDPASYLVKVGVGLESKLQESFQGAPDVISPRYD 610 620 630 640 650 660 640 650 660 670 680 690 pF1KE4 PDSGHDSGAEDATVEASPPFAFLTIGMGKILLGSGASSNAGLTGRDGPTAGCTVPLPPRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDSGHDSGAEDATVEASPPFAFLTIGMGKILLGSGASSNAGLTGRDGPTAGCTVPLPPRL 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE4 GICLDYERGRVSFLDAVSFRGLLECPLDCSGPVCPAFCFIGGGAVQLQEPVGTKPERKVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GICLDYERGRVSFLDAVSFRGLLECPLDCSGPVCPAFCFIGGGAVQLQEPVGTKPERKVT 730 740 750 760 770 780 pF1KE4 IGGFAKLD :::::::: XP_011 IGGFAKLD >>NP_001243530 (OMIM: 600986) tripartite motif-containin (746 aa) initn: 5086 init1: 5086 opt: 5086 Z-score: 4375.7 bits: 820.3 E(85289): 0 Smith-Waterman score: 5086; 100.0% identity (100.0% similar) in 738 aa overlap (22-759:9-746) 10 20 30 40 50 60 pF1KE4 MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV ::::::::::::::::::::::::::::::::::::::: NP_001 MGAKGNGLTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV 10 20 30 40 70 80 90 100 110 120 pF1KE4 LGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGA 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE4 LHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPL 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE4 EATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKT 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE4 CQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEEAVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEEAVR 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE4 HTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLLDGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLLDGS 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE4 GLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKL 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE4 LTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRW 410 420 430 440 450 460 490 500 510 520 530 540 pF1KE4 QRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDSRWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDSRWG 470 480 490 500 510 520 550 560 570 580 590 600 pF1KE4 ASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWACAVDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWACAVDP 530 540 550 560 570 580 610 620 630 640 650 660 pF1KE4 ASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTIGMGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTIGMGK 590 600 610 620 630 640 670 680 690 700 710 720 pF1KE4 ILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLECPLDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLECPLDC 650 660 670 680 690 700 730 740 750 pF1KE4 SGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD ::::::::::::::::::::::::::::::::::::::: NP_001 SGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD 710 720 730 740 >>XP_016857882 (OMIM: 600986) PREDICTED: tripartite moti (746 aa) initn: 5086 init1: 5086 opt: 5086 Z-score: 4375.7 bits: 820.3 E(85289): 0 Smith-Waterman score: 5086; 100.0% identity (100.0% similar) in 738 aa overlap (22-759:9-746) 10 20 30 40 50 60 pF1KE4 MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV ::::::::::::::::::::::::::::::::::::::: XP_016 MAAKRGTKTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV 10 20 30 40 70 80 90 100 110 120 pF1KE4 LGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGA 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE4 LHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPL 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE4 EATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKT 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE4 CQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEEAVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEEAVR 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE4 HTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLLDGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLLDGS 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE4 GLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKL 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE4 LTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRW 410 420 430 440 450 460 490 500 510 520 530 540 pF1KE4 QRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDSRWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDSRWG 470 480 490 500 510 520 550 560 570 580 590 600 pF1KE4 ASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWACAVDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWACAVDP 530 540 550 560 570 580 610 620 630 640 650 660 pF1KE4 ASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTIGMGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTIGMGK 590 600 610 620 630 640 670 680 690 700 710 720 pF1KE4 ILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLECPLDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLECPLDC 650 660 670 680 690 700 730 740 750 pF1KE4 SGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD ::::::::::::::::::::::::::::::::::::::: XP_016 SGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD 710 720 730 740 >>NP_001243528 (OMIM: 600986) tripartite motif-containin (736 aa) initn: 5076 init1: 5076 opt: 5076 Z-score: 4367.2 bits: 818.8 E(85289): 0 Smith-Waterman score: 5076; 100.0% identity (100.0% similar) in 736 aa overlap (24-759:1-736) 10 20 30 40 50 60 pF1KE4 MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV ::::::::::::::::::::::::::::::::::::: NP_001 MKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV 10 20 30 70 80 90 100 110 120 pF1KE4 LGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGA 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE4 LHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPL 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE4 EATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKT 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE4 CQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEEAVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEEAVR 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE4 HTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLLDGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLLDGS 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE4 GLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKL 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE4 LTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRW 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE4 QRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDSRWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDSRWG 460 470 480 490 500 510 550 560 570 580 590 600 pF1KE4 ASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWACAVDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWACAVDP 520 530 540 550 560 570 610 620 630 640 650 660 pF1KE4 ASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTIGMGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTIGMGK 580 590 600 610 620 630 670 680 690 700 710 720 pF1KE4 ILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLECPLDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLECPLDC 640 650 660 670 680 690 730 740 750 pF1KE4 SGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD ::::::::::::::::::::::::::::::::::::::: NP_001 SGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD 700 710 720 730 >>NP_001269307 (OMIM: 600986) tripartite motif-containin (633 aa) initn: 4347 init1: 4347 opt: 4347 Z-score: 3741.8 bits: 702.8 E(85289): 1.1e-201 Smith-Waterman score: 4347; 100.0% identity (100.0% similar) in 633 aa overlap (127-759:1-633) 100 110 120 130 140 150 pF1KE4 PKPDRLDRLLKSGFGTYPGRKRGALHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERV :::::::::::::::::::::::::::::: NP_001 MFPCPACQGDVELGERGLAGLFRNLTLERV 10 20 30 160 170 180 190 200 210 pF1KE4 VERYRQSVSVGGAILCQLCKPPPLEATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VERYRQSVSVGGAILCQLCKPPPLEATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLP 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE4 TLSFRPKGLMCPDHKEEVTHYCKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLSFRPKGLMCPDHKEEVTHYCKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTK 100 110 120 130 140 150 280 290 300 310 320 330 pF1KE4 SLTYILGNQDTVQTQICELEEAVRHTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLTYILGNQDTVQTQICELEEAVRHTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIE 160 170 180 190 200 210 340 350 360 370 380 390 pF1KE4 ECQQERLARLSAQIQEHRSLLDGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ECQQERLARLSAQIQEHRSLLDGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEAL 220 230 240 250 260 270 400 410 420 430 440 450 pF1KE4 QTFRPAASSSFRHCQLDVGREMKLLTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QTFRPAASSSFRHCQLDVGREMKLLTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHS 280 290 300 310 320 330 460 470 480 490 500 510 pF1KE4 PPAWHYTVEFRRTDVPAQPGPTRWQRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPAWHYTVEFRRTDVPAQPGPTRWQRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGE 340 350 360 370 380 390 520 530 540 550 560 570 pF1KE4 YSEDVHLHTPPAPVLHFFLDSRWGASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YSEDVHLHTPPAPVLHFFLDSRWGASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHL 400 410 420 430 440 450 580 590 600 610 620 630 pF1KE4 SVDVVLGDVAVTQGRSYWACAVDPASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVDVVLGDVAVTQGRSYWACAVDPASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGH 460 470 480 490 500 510 640 650 660 670 680 690 pF1KE4 DSGAEDATVEASPPFAFLTIGMGKILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSGAEDATVEASPPFAFLTIGMGKILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLD 520 530 540 550 560 570 700 710 720 730 740 750 pF1KE4 YERGRVSFLDAVSFRGLLECPLDCSGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YERGRVSFLDAVSFRGLLECPLDCSGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFA 580 590 600 610 620 630 pF1KE4 KLD ::: NP_001 KLD >>NP_001269308 (OMIM: 600986) tripartite motif-containin (551 aa) initn: 3647 init1: 3647 opt: 3649 Z-score: 3142.9 bits: 591.8 E(85289): 2.5e-168 Smith-Waterman score: 3649; 98.5% identity (98.9% similar) in 541 aa overlap (1-541:1-540) 10 20 30 40 50 60 pF1KE4 MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 EATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 CQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEEAVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEEAVR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 HTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLLDGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLLDGS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 GLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 LTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRW 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 QRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDSRWG ::::::::::::::::::::::::::::::::::::::::::::::::: .. : : : NP_001 QRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPGIQN-LARRGG 490 500 510 520 530 550 560 570 580 590 600 pF1KE4 ASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWACAVDP : NP_001 ACLQFQLLGRLR 540 550 >>NP_001243529 (OMIM: 600986) tripartite motif-containin (717 aa) initn: 2974 init1: 2974 opt: 2974 Z-score: 2561.6 bits: 484.6 E(85289): 6.1e-136 Smith-Waterman score: 4843; 96.1% identity (96.1% similar) in 738 aa overlap (22-759:9-717) 10 20 30 40 50 60 pF1KE4 MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV ::::::::::::::::::::::::::::::::::::::: NP_001 MAAKRGTKTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV 10 20 30 40 70 80 90 100 110 120 pF1KE4 LGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGA 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE4 LHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPL 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE4 EATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKT 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE4 CQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEEAVR ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEE--- 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE4 HTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLLDGS :::::::::::::::::::::::::::::::::: NP_001 --------------------------KRASLLQAIEECQQERLARLSAQIQEHRSLLDGS 290 300 310 370 380 390 400 410 420 pF1KE4 GLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKL 320 330 340 350 360 370 430 440 450 460 470 480 pF1KE4 LTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRW 380 390 400 410 420 430 490 500 510 520 530 540 pF1KE4 QRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDSRWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDSRWG 440 450 460 470 480 490 550 560 570 580 590 600 pF1KE4 ASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWACAVDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWACAVDP 500 510 520 530 540 550 610 620 630 640 650 660 pF1KE4 ASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTIGMGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTIGMGK 560 570 580 590 600 610 670 680 690 700 710 720 pF1KE4 ILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLECPLDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLECPLDC 620 630 640 650 660 670 730 740 750 pF1KE4 SGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD ::::::::::::::::::::::::::::::::::::::: NP_001 SGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD 680 690 700 710 >>XP_016865110 (OMIM: 609317) PREDICTED: E3 ubiquitin-pr (745 aa) initn: 1473 init1: 626 opt: 1972 Z-score: 1700.6 bits: 325.4 E(85289): 5.5e-88 Smith-Waterman score: 2131; 41.8% identity (75.2% similar) in 749 aa overlap (1-745:1-737) 10 20 30 40 50 60 pF1KE4 MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV :.:. .:. : ::. ... ....::.:.::.::.:.:.. .::.::: :..:. :..:. XP_016 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 LG--QQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKR : .... :.: :.. . :: ...: . : .: . .. : :: XP_016 LLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRPASQRRSVGWRGHKKLLNGWKR 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE4 GALHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPP ..: :.. .::::.:. ::.:::::. :::::.::: .::::::.. .. ::.:.::::: XP_016 NSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPP 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 PLEATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHK-EEVTHY : :.::.: .: :..::::::. ::::: ::::: . :: .:::: ::::.:. :... : XP_016 PQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMY 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE4 CKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEE :. :.: ::.::.. .:..:..: . :::..::.::.:.. :..:... :..:: ::. XP_016 CELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNL 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE4 AVRHTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLL ...:: .:..::::. . : ::::...:.:.::. .. :: ....:..:...:: XP_016 LMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLL 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE4 DGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGRE ...::::::::::::::: ::::.::::: :: .:::.:..:::::..::. ...... XP_016 ENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQ 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE4 MKLLTELNFLRVP-EAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPG .:: ::.:. ..: :. ... .:.. .. :. :.. : :..:.:. . . XP_016 TELLGELSFFSSGIDVPEINEEQSKVYNNALINWH-HPEKDKADSYVLEYRKIN---RDD 430 440 450 460 470 480 490 500 510 520 530 pF1KE4 PTRWQRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLD :.. : : ::: .... ...:.:..:::. . . . :... ::::::::. :..: XP_016 EMSWNEIE-VCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFD 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE4 SRWGASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWAC . : . :.: .. . :.: :. :::::.:. .: . :.: ..::...:.:. .:: XP_016 EKCGYNNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAF 540 550 560 570 580 590 600 610 620 630 640 650 pF1KE4 AVDPASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTI :.: ::::::::. .:::: ... :..::::. :::::::.::: ..: ::...:: XP_016 RVEPYSYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTI 600 610 620 630 640 650 660 670 680 690 700 710 pF1KE4 GMGKILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLEC :: :... .. .:. .: ..:.: .:: :: ..:.:.: : ... : : XP_016 GMQKFFIPKSPTSSNEPENR-------VLPMPTSIGIFLDCDKGKVDFYDMDQMKCLYER 660 670 680 690 700 720 730 740 750 pF1KE4 PLDCSGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD .::: . ::: ..:.:..::.::. .: XP_016 QVDCSHTLYPAFALMGSGGIQLEEPITAKYLEYQEDM 710 720 730 740 >>XP_016865111 (OMIM: 609317) PREDICTED: E3 ubiquitin-pr (733 aa) initn: 1456 init1: 626 opt: 1936 Z-score: 1669.8 bits: 319.6 E(85289): 2.9e-86 Smith-Waterman score: 2095; 42.2% identity (75.2% similar) in 727 aa overlap (23-745:11-725) 10 20 30 40 50 60 pF1KE4 MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV ..::.:.::.::.:.:.. .::.::: :..:. :..:. XP_016 MEGDGSDSPVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL 10 20 30 40 70 80 90 100 110 pF1KE4 LG--QQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKR : .... :.: :.. . :: ...: . : .: . .. : :: XP_016 LLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRPASQRRSVGWRGHKKLLNGWKR 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE4 GALHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPP ..: :.. .::::.:. ::.:::::. :::::.::: .::::::.. .. ::.:.::::: XP_016 NSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPP 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE4 PLEATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHK-EEVTHY : :.::.: .: :..::::::. ::::: ::::: . :: .:::: ::::.:. :... : XP_016 PQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMY 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE4 CKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEE :. :.: ::.::.. .:..:..: . :::..::.::.:.. :..:... :..:: ::. XP_016 CELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNL 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE4 AVRHTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLL ...:: .:..::::. . : ::::...:.:.::. .. :: ....:..:...:: XP_016 LMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLL 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE4 DGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGRE ...::::::::::::::: ::::.::::: :: .:::.:..:::::..::. ...... XP_016 ENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQ 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE4 MKLLTELNFLRVP-EAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPG .:: ::.:. ..: :. ... .:.. .. :. :.. : :..:.:. . . XP_016 TELLGELSFFSSGIDVPEINEEQSKVYNNALINWH-HPEKDKADSYVLEYRKIN---RDD 410 420 430 440 450 460 480 490 500 510 520 530 pF1KE4 PTRWQRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLD :.. : : ::: .... ...:.:..:::. . . . :... ::::::::. :..: XP_016 EMSWNEIE-VCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFD 470 480 490 500 510 520 540 550 560 570 580 590 pF1KE4 SRWGASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWAC . : . :.: .. . :.: :. :::::.:. .: . :.: ..::...:.:. .:: XP_016 EKCGYNNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAF 530 540 550 560 570 580 600 610 620 630 640 650 pF1KE4 AVDPASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTI :.: ::::::::. .:::: ... :..::::. :::::::.::: ..: ::...:: XP_016 RVEPYSYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTI 590 600 610 620 630 640 660 670 680 690 700 710 pF1KE4 GMGKILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLEC :: :... .. .:. .: ..:.: .:: :: ..:.:.: : ... : : XP_016 GMQKFFIPKSPTSSNEPENR-------VLPMPTSIGIFLDCDKGKVDFYDMDQMKCLYER 650 660 670 680 690 720 730 740 750 pF1KE4 PLDCSGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD .::: . ::: ..:.:..::.::. .: XP_016 QVDCSHTLYPAFALMGSGGIQLEEPITAKYLEYQEDM 700 710 720 730 759 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 16:51:20 2016 done: Mon Nov 7 16:51:22 2016 Total Scan time: 10.360 Total Display time: 0.170 Function used was FASTA [36.3.4 Apr, 2011]