FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3136, 348 aa 1>>>pF1KE3136 348 - 348 aa - 348 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8551+/-0.000316; mu= 13.7438+/- 0.020 mean_var=78.8453+/-15.840, 0's: 0 Z-trim(117.6): 31 B-trim: 0 in 0/55 Lambda= 0.144440 statistics sampled from 29657 (29687) to 29657 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.716), E-opt: 0.2 (0.348), width: 16 Scan time: 6.240 The best scores are: opt bits E(85289) NP_061036 (OMIM: 612023) ubiquitin thioesterase OT ( 348) 2373 503.7 2.4e-142 NP_001263249 (OMIM: 612023) ubiquitin thioesterase ( 304) 1930 411.4 1.3e-114 NP_079330 (OMIM: 611745) deubiquitinating protein (1222) 157 42.2 0.007 >>NP_061036 (OMIM: 612023) ubiquitin thioesterase OTU1 i (348 aa) initn: 2373 init1: 2373 opt: 2373 Z-score: 2676.6 bits: 503.7 E(85289): 2.4e-142 Smith-Waterman score: 2373; 100.0% identity (100.0% similar) in 348 aa overlap (1-348:1-348) 10 20 30 40 50 60 pF1KE3 MFGPAKGRHFGVHPAPGFPGGVSQQAAGTKAGPAGAWPVGSRTDTMWRLRCKAKDGTHVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 MFGPAKGRHFGVHPAPGFPGGVSQQAAGTKAGPAGAWPVGSRTDTMWRLRCKAKDGTHVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 QGLSSRTRVRELQGQIAAITGIAPGGQRILVGYPPECLDLSNGDTILEDLPIQSGDMLII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 QGLSSRTRVRELQGQIAAITGIAPGGQRILVGYPPECLDLSNGDTILEDLPIQSGDMLII 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 EEDQTRPRSSPAFTKRGASSYVRETLPVLTRTVVPADNSCLFTSVYYVVEGGVLNPACAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 EEDQTRPRSSPAFTKRGASSYVRETLPVLTRTVVPADNSCLFTSVYYVVEGGVLNPACAP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 EMRRLIAQIVASDPDFYSEAILGKTNQEYCDWIKRDDTWGGAIEISILSKFYQCEICVVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 EMRRLIAQIVASDPDFYSEAILGKTNQEYCDWIKRDDTWGGAIEISILSKFYQCEICVVD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 TQTVRIDRFGEDAGYTKRVLLIYDGIHYDPLQRNFPDPDTPPLTIFSSNDDIVLVQALEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 TQTVRIDRFGEDAGYTKRVLLIYDGIHYDPLQRNFPDPDTPPLTIFSSNDDIVLVQALEL 250 260 270 280 290 300 310 320 330 340 pF1KE3 ADEARRRRQFTDVNRFTLRCMVCQKGLTGQAEAREHAKETGHTNFGEV :::::::::::::::::::::::::::::::::::::::::::::::: NP_061 ADEARRRRQFTDVNRFTLRCMVCQKGLTGQAEAREHAKETGHTNFGEV 310 320 330 340 >>NP_001263249 (OMIM: 612023) ubiquitin thioesterase OTU (304 aa) initn: 1929 init1: 1929 opt: 1930 Z-score: 2178.6 bits: 411.4 E(85289): 1.3e-114 Smith-Waterman score: 1930; 95.4% identity (97.7% similar) in 305 aa overlap (44-348:2-304) 20 30 40 50 60 70 pF1KE3 PAPGFPGGVSQQAAGTKAGPAGAWPVGSRTDTMWRLRCKAKDGTHVLQGLSSRTRVRELQ .:. . .::. : ..:::::::::::: NP_001 METLHIIYSEAKSFT--VEGLSSRTRVRELQ 10 20 80 90 100 110 120 130 pF1KE3 GQIAAITGIAPGGQRILVGYPPECLDLSNGDTILEDLPIQSGDMLIIEEDQTRPRSSPAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQIAAITGIAPGGQRILVGYPPECLDLSNGDTILEDLPIQSGDMLIIEEDQTRPRSSPAF 30 40 50 60 70 80 140 150 160 170 180 190 pF1KE3 TKRGASSYVRETLPVLTRTVVPADNSCLFTSVYYVVEGGVLNPACAPEMRRLIAQIVASD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TKRGASSYVRETLPVLTRTVVPADNSCLFTSVYYVVEGGVLNPACAPEMRRLIAQIVASD 90 100 110 120 130 140 200 210 220 230 240 250 pF1KE3 PDFYSEAILGKTNQEYCDWIKRDDTWGGAIEISILSKFYQCEICVVDTQTVRIDRFGEDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PDFYSEAILGKTNQEYCDWIKRDDTWGGAIEISILSKFYQCEICVVDTQTVRIDRFGEDA 150 160 170 180 190 200 260 270 280 290 300 310 pF1KE3 GYTKRVLLIYDGIHYDPLQRNFPDPDTPPLTIFSSNDDIVLVQALELADEARRRRQFTDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GYTKRVLLIYDGIHYDPLQRNFPDPDTPPLTIFSSNDDIVLVQALELADEARRRRQFTDV 210 220 230 240 250 260 320 330 340 pF1KE3 NRFTLRCMVCQKGLTGQAEAREHAKETGHTNFGEV ::::::::::::::::::::::::::::::::::: NP_001 NRFTLRCMVCQKGLTGQAEAREHAKETGHTNFGEV 270 280 290 300 >>NP_079330 (OMIM: 611745) deubiquitinating protein VCIP (1222 aa) initn: 133 init1: 133 opt: 157 Z-score: 172.7 bits: 42.2 E(85289): 0.007 Smith-Waterman score: 157; 28.7% identity (52.4% similar) in 143 aa overlap (6-148:740-876) 10 20 30 pF1KE3 MFGPAKGRHFGVHPAPGFPGGVSQQAAGTKAGPAG ::. : :. : : :. ::: NP_079 SKTERTIQQNITEQASVMQKRKTEKLKQEQKGQPRTVSPSTIRDGPSSAPATPTKA---- 710 720 730 740 750 760 40 50 60 70 80 90 pF1KE3 AWPVGSRTDTMWRLRCKAKDGTHVLQGLSSRTRVRELQGQIAAITGIAPGGQRILVGYPP : . :. ..: ..:: . . :.: : ::: .:: .: : : : :.:: NP_079 --PYSPTTSKEKKIRITTNDGRQSMVTLKSSTTFFELQESIAREFNIPPYLQCIRYGFPP 770 780 790 800 810 820 100 110 120 130 140 150 pF1KE3 ECLDLSNGDTILEDLPIQSGDMLIIEEDQTRPRSSPAFTKRGASSYVRETLPVLTRTVVP . : .. : .:.: :: . :: ... ... . . ..: . .: . : NP_079 KELMPPQAGMEKEPVPLQHGDRITIEILKSKAEGGQSAAAHSAHTVKQEDIAVTGKLSSK 830 840 850 860 870 880 160 170 180 190 200 210 pF1KE3 ADNSCLFTSVYYVVEGGVLNPACAPEMRRLIAQIVASDPDFYSEAILGKTNQEYCDWIKR NP_079 ELQEQAEKEMYSLCLLATLMGEDVWSYAKGLPHMFQQGGVFYSIMKKTMGMADGKHCTFP 890 900 910 920 930 940 348 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 16:42:50 2016 done: Mon Nov 7 16:42:51 2016 Total Scan time: 6.240 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]