FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4208, 728 aa 1>>>pF1KE4208 728 - 728 aa - 728 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.8892+/-0.000441; mu= 13.1043+/- 0.028 mean_var=151.8294+/-32.128, 0's: 0 Z-trim(113.8): 182 B-trim: 0 in 0/58 Lambda= 0.104087 statistics sampled from 23140 (23345) to 23140 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.628), E-opt: 0.2 (0.274), width: 16 Scan time: 11.990 The best scores are: opt bits E(85289) NP_061170 (OMIM: 609317) E3 ubiquitin-protein liga ( 728) 4941 754.9 2.6e-217 NP_001287688 (OMIM: 609317) E3 ubiquitin-protein l ( 716) 4809 735.1 2.3e-211 XP_016865111 (OMIM: 609317) PREDICTED: E3 ubiquiti ( 733) 4267 653.7 7.5e-187 XP_016865110 (OMIM: 609317) PREDICTED: E3 ubiquiti ( 745) 4267 653.7 7.6e-187 NP_001287681 (OMIM: 609317) E3 ubiquitin-protein l ( 573) 3881 595.6 1.8e-169 XP_016865112 (OMIM: 609317) PREDICTED: E3 ubiquiti ( 529) 2793 432.2 2.6e-120 NP_001243528 (OMIM: 600986) tripartite motif-conta ( 736) 1779 280.1 2.2e-74 XP_016857882 (OMIM: 600986) PREDICTED: tripartite ( 746) 1779 280.1 2.2e-74 NP_001243530 (OMIM: 600986) tripartite motif-conta ( 746) 1779 280.1 2.2e-74 NP_079334 (OMIM: 600986) tripartite motif-containi ( 759) 1779 280.1 2.3e-74 XP_011508304 (OMIM: 600986) PREDICTED: tripartite ( 788) 1779 280.1 2.3e-74 NP_001269307 (OMIM: 600986) tripartite motif-conta ( 633) 1708 269.4 3.2e-71 NP_001269308 (OMIM: 600986) tripartite motif-conta ( 551) 1365 217.8 9.4e-56 NP_001243529 (OMIM: 600986) tripartite motif-conta ( 717) 838 138.8 7.5e-32 XP_016876437 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 688) 644 109.6 4.3e-23 XP_016876435 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 706) 644 109.6 4.4e-23 XP_016876432 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 791) 633 108.0 1.5e-22 XP_011534691 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 802) 633 108.0 1.5e-22 XP_016876436 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 692) 610 104.5 1.5e-21 NP_055978 (OMIM: 606555) E3 ubiquitin-protein liga ( 710) 610 104.5 1.5e-21 XP_016876434 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 710) 610 104.5 1.5e-21 NP_443210 (OMIM: 606555) E3 ubiquitin-protein liga ( 550) 599 102.8 4e-21 XP_005267359 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 714) 599 102.9 4.8e-21 XP_016876433 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 732) 599 102.9 4.9e-21 XP_005267358 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 777) 599 102.9 5.1e-21 XP_006720081 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 795) 599 102.9 5.2e-21 NP_001180206 (OMIM: 189960,300000,300552) E3 ubiqu ( 667) 570 98.5 9.3e-20 NP_000372 (OMIM: 189960,300000,300552) E3 ubiquiti ( 667) 570 98.5 9.3e-20 NP_001092094 (OMIM: 189960,300000,300552) E3 ubiqu ( 667) 570 98.5 9.3e-20 XP_016885025 (OMIM: 189960,300000,300552) PREDICTE ( 667) 570 98.5 9.3e-20 NP_150632 (OMIM: 189960,300000,300552) E3 ubiquiti ( 667) 570 98.5 9.3e-20 XP_016885031 (OMIM: 189960,300000,300552) PREDICTE ( 489) 565 97.6 1.3e-19 NP_001180208 (OMIM: 189960,300000,300552) E3 ubiqu ( 489) 565 97.6 1.3e-19 XP_016885029 (OMIM: 189960,300000,300552) PREDICTE ( 552) 565 97.7 1.4e-19 XP_016884728 (OMIM: 300204,300928) PREDICTED: prob ( 685) 558 96.7 3.3e-19 NP_438112 (OMIM: 300204,300928) probable E3 ubiqui ( 705) 558 96.7 3.4e-19 XP_005262119 (OMIM: 300204,300928) PREDICTED: prob ( 715) 558 96.7 3.4e-19 NP_036348 (OMIM: 300204,300928) probable E3 ubiqui ( 735) 558 96.7 3.5e-19 XP_016876439 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 593) 531 92.6 5e-18 XP_016876438 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 611) 531 92.6 5.1e-18 XP_011542494 (OMIM: 610584) PREDICTED: tripartite ( 781) 434 78.1 1.5e-13 NP_001287818 (OMIM: 610584) tripartite motif-conta ( 721) 429 77.3 2.3e-13 NP_001004342 (OMIM: 610584) tripartite motif-conta ( 783) 429 77.4 2.5e-13 XP_016856812 (OMIM: 610584) PREDICTED: tripartite ( 854) 429 77.4 2.6e-13 NP_001274121 (OMIM: 609829) FSD1-like protein isof ( 497) 409 74.2 1.4e-12 XP_011517381 (OMIM: 609829) PREDICTED: FSD1-like p ( 542) 409 74.2 1.5e-12 XP_016870671 (OMIM: 609829) PREDICTED: FSD1-like p ( 529) 405 73.6 2.3e-12 XP_016870672 (OMIM: 609829) PREDICTED: FSD1-like p ( 498) 403 73.3 2.7e-12 XP_011517380 (OMIM: 609829) PREDICTED: FSD1-like p ( 543) 403 73.3 2.8e-12 NP_001138785 (OMIM: 609829) FSD1-like protein isof ( 530) 399 72.7 4.2e-12 >>NP_061170 (OMIM: 609317) E3 ubiquitin-protein ligase T (728 aa) initn: 4941 init1: 4941 opt: 4941 Z-score: 4022.6 bits: 754.9 E(85289): 2.6e-217 Smith-Waterman score: 4941; 99.9% identity (100.0% similar) in 728 aa overlap (1-728:1-728) 10 20 30 40 50 60 pF1KE4 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRPGWKRNSLTPRTTVFPCPGCEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 LLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRPGWKRNSLTPRTTVFPCPGCEH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPPPQESTKSCMDCSASYCN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 DVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPPPQESTKSCMDCSASYCN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 ECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMYCELCRRPVCHLCKLGGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 ECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMYCELCRRPVCHLCKLGGN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 HANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNLLMKETECNGERAKEEAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 HANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNLLMKETECNGERAKEEAI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 THFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLLENNGLVGYAQEVLKETD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 THFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLLENNGLVGYAQEVLKETD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 QSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQTELLGELSFFSSGIDVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 QSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQTELLGELSFFSSGIDVP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 EINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSWNEIEVCGTSKIIQDLEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 EINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSWNEIEVCGTSKIIQDLEN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 SSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGYNNEHLLLNLKRDRVESR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 SSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGYNNEHLLLNLKRDRVESR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 AGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPYSYLVKVGVASSDKLQEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 AGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPYSYLVKVGVASSDKLQEW 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 LRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKFFIPKSPTSSNEPENRVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 LRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKFFIPKSPTSSNEPENRVL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE4 PMPTSIGIFLDCDKGKVNFYDMDQMKCLYERQVDCSHTLYPAFALMGSGGIQLEEPITAK :::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::: NP_061 PMPTSIGIFLDCDKGKVDFYDMDQMKCLYERQVDCSHTLYPAFALMGSGGIQLEEPITAK 670 680 690 700 710 720 pF1KE4 YLEYQEDM :::::::: NP_061 YLEYQEDM >>NP_001287688 (OMIM: 609317) E3 ubiquitin-protein ligas (716 aa) initn: 4809 init1: 4809 opt: 4809 Z-score: 3915.5 bits: 735.1 E(85289): 2.3e-211 Smith-Waterman score: 4809; 99.9% identity (100.0% similar) in 707 aa overlap (22-728:10-716) 10 20 30 40 50 60 pF1KE4 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL ::::::::::::::::::::::::::::::::::::::: NP_001 MEGDGSDSPVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL 10 20 30 40 70 80 90 100 110 120 pF1KE4 LLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRPGWKRNSLTPRTTVFPCPGCEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRPGWKRNSLTPRTTVFPCPGCEH 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE4 DVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPPPQESTKSCMDCSASYCN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPPPQESTKSCMDCSASYCN 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE4 ECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMYCELCRRPVCHLCKLGGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMYCELCRRPVCHLCKLGGN 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE4 HANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNLLMKETECNGERAKEEAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNLLMKETECNGERAKEEAI 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE4 THFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLLENNGLVGYAQEVLKETD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 THFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLLENNGLVGYAQEVLKETD 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE4 QSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQTELLGELSFFSSGIDVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQTELLGELSFFSSGIDVP 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE4 EINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSWNEIEVCGTSKIIQDLEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSWNEIEVCGTSKIIQDLEN 410 420 430 440 450 460 490 500 510 520 530 540 pF1KE4 SSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGYNNEHLLLNLKRDRVESR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGYNNEHLLLNLKRDRVESR 470 480 490 500 510 520 550 560 570 580 590 600 pF1KE4 AGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPYSYLVKVGVASSDKLQEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPYSYLVKVGVASSDKLQEW 530 540 550 560 570 580 610 620 630 640 650 660 pF1KE4 LRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKFFIPKSPTSSNEPENRVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKFFIPKSPTSSNEPENRVL 590 600 610 620 630 640 670 680 690 700 710 720 pF1KE4 PMPTSIGIFLDCDKGKVNFYDMDQMKCLYERQVDCSHTLYPAFALMGSGGIQLEEPITAK :::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::: NP_001 PMPTSIGIFLDCDKGKVDFYDMDQMKCLYERQVDCSHTLYPAFALMGSGGIQLEEPITAK 650 660 670 680 690 700 pF1KE4 YLEYQEDM :::::::: NP_001 YLEYQEDM 710 >>XP_016865111 (OMIM: 609317) PREDICTED: E3 ubiquitin-pr (733 aa) initn: 4267 init1: 4267 opt: 4267 Z-score: 3475.5 bits: 653.7 E(85289): 7.5e-187 Smith-Waterman score: 4765; 97.5% identity (97.7% similar) in 724 aa overlap (22-728:10-733) 10 20 30 40 50 60 pF1KE4 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL ::::::::::::::::::::::::::::::::::::::: XP_016 MEGDGSDSPVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL 10 20 30 40 70 80 90 100 pF1KE4 LLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRP-----------------GWKR ::::::::::::::::::::::::::::::::::::::: :::: XP_016 LLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRPASQRRSVGWRGHKKLLNGWKR 50 60 70 80 90 100 110 120 130 140 150 160 pF1KE4 NSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPP 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE4 PQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMY 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE4 CELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNL 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE4 LMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLL 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE4 ENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQ 350 360 370 380 390 400 410 420 430 440 450 460 pF1KE4 TELLGELSFFSSGIDVPEINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TELLGELSFFSSGIDVPEINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSW 410 420 430 440 450 460 470 480 490 500 510 520 pF1KE4 NEIEVCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NEIEVCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGY 470 480 490 500 510 520 530 540 550 560 570 580 pF1KE4 NNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPY 530 540 550 560 570 580 590 600 610 620 630 640 pF1KE4 SYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKF 590 600 610 620 630 640 650 660 670 680 690 700 pF1KE4 FIPKSPTSSNEPENRVLPMPTSIGIFLDCDKGKVNFYDMDQMKCLYERQVDCSHTLYPAF ::::::::::::::::::::::::::::::::::.::::::::::::::::::::::::: XP_016 FIPKSPTSSNEPENRVLPMPTSIGIFLDCDKGKVDFYDMDQMKCLYERQVDCSHTLYPAF 650 660 670 680 690 700 710 720 pF1KE4 ALMGSGGIQLEEPITAKYLEYQEDM ::::::::::::::::::::::::: XP_016 ALMGSGGIQLEEPITAKYLEYQEDM 710 720 730 >>XP_016865110 (OMIM: 609317) PREDICTED: E3 ubiquitin-pr (745 aa) initn: 4267 init1: 4267 opt: 4267 Z-score: 3475.4 bits: 653.7 E(85289): 7.6e-187 Smith-Waterman score: 4897; 97.6% identity (97.7% similar) in 745 aa overlap (1-728:1-745) 10 20 30 40 50 60 pF1KE4 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL 10 20 30 40 50 60 70 80 90 100 pF1KE4 LLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRP-----------------GWKR ::::::::::::::::::::::::::::::::::::::: :::: XP_016 LLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRPASQRRSVGWRGHKKLLNGWKR 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE4 NSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPP 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE4 PQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMY 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE4 CELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNL 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE4 LMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLL 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE4 ENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQ 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE4 TELLGELSFFSSGIDVPEINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TELLGELSFFSSGIDVPEINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSW 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE4 NEIEVCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NEIEVCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGY 490 500 510 520 530 540 530 540 550 560 570 580 pF1KE4 NNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPY 550 560 570 580 590 600 590 600 610 620 630 640 pF1KE4 SYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKF 610 620 630 640 650 660 650 660 670 680 690 700 pF1KE4 FIPKSPTSSNEPENRVLPMPTSIGIFLDCDKGKVNFYDMDQMKCLYERQVDCSHTLYPAF ::::::::::::::::::::::::::::::::::.::::::::::::::::::::::::: XP_016 FIPKSPTSSNEPENRVLPMPTSIGIFLDCDKGKVDFYDMDQMKCLYERQVDCSHTLYPAF 670 680 690 700 710 720 710 720 pF1KE4 ALMGSGGIQLEEPITAKYLEYQEDM ::::::::::::::::::::::::: XP_016 ALMGSGGIQLEEPITAKYLEYQEDM 730 740 >>NP_001287681 (OMIM: 609317) E3 ubiquitin-protein ligas (573 aa) initn: 3881 init1: 3881 opt: 3881 Z-score: 3163.6 bits: 595.6 E(85289): 1.8e-169 Smith-Waterman score: 3881; 99.8% identity (100.0% similar) in 573 aa overlap (156-728:1-573) 130 140 150 160 170 180 pF1KE4 ERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPPPQESTKSCMDCSASYCNECFKI :::::::::::::::::::::::::::::: NP_001 MCDLCKPPPQESTKSCMDCSASYCNECFKI 10 20 30 190 200 210 220 230 240 pF1KE4 HHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMYCELCRRPVCHLCKLGGNHANHR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMYCELCRRPVCHLCKLGGNHANHR 40 50 60 70 80 90 250 260 270 280 290 300 pF1KE4 VTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNLLMKETECNGERAKEEAITHFEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNLLMKETECNGERAKEEAITHFEK 100 110 120 130 140 150 310 320 330 340 350 360 pF1KE4 LFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLLENNGLVGYAQEVLKETDQSCFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLLENNGLVGYAQEVLKETDQSCFV 160 170 180 190 200 210 370 380 390 400 410 420 pF1KE4 QTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQTELLGELSFFSSGIDVPEINEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQTELLGELSFFSSGIDVPEINEE 220 230 240 250 260 270 430 440 450 460 470 480 pF1KE4 QSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSWNEIEVCGTSKIIQDLENSSTYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSWNEIEVCGTSKIIQDLENSSTYA 280 290 300 310 320 330 490 500 510 520 530 540 pF1KE4 FRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGYNNEHLLLNLKRDRVESRAGFNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGYNNEHLLLNLKRDRVESRAGFNL 340 350 360 370 380 390 550 560 570 580 590 600 pF1KE4 LLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPYSYLVKVGVASSDKLQEWLRSPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPYSYLVKVGVASSDKLQEWLRSPR 400 410 420 430 440 450 610 620 630 640 650 660 pF1KE4 DAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKFFIPKSPTSSNEPENRVLPMPTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKFFIPKSPTSSNEPENRVLPMPTS 460 470 480 490 500 510 670 680 690 700 710 720 pF1KE4 IGIFLDCDKGKVNFYDMDQMKCLYERQVDCSHTLYPAFALMGSGGIQLEEPITAKYLEYQ ::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IGIFLDCDKGKVDFYDMDQMKCLYERQVDCSHTLYPAFALMGSGGIQLEEPITAKYLEYQ 520 530 540 550 560 570 pF1KE4 EDM ::: NP_001 EDM >>XP_016865112 (OMIM: 609317) PREDICTED: E3 ubiquitin-pr (529 aa) initn: 2793 init1: 2793 opt: 2793 Z-score: 2281.1 bits: 432.2 E(85289): 2.6e-120 Smith-Waterman score: 3423; 96.8% identity (96.8% similar) in 528 aa overlap (1-511:1-528) 10 20 30 40 50 60 pF1KE4 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL 10 20 30 40 50 60 70 80 90 100 pF1KE4 LLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRP-----------------GWKR ::::::::::::::::::::::::::::::::::::::: :::: XP_016 LLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRPASQRRSVGWRGHKKLLNGWKR 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE4 NSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPP 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE4 PQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMY 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE4 CELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNL 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE4 LMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLL 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE4 ENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQ 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE4 TELLGELSFFSSGIDVPEINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TELLGELSFFSSGIDVPEINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSW 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE4 NEIEVCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGY :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NEIEVCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPG 490 500 510 520 530 540 550 560 570 580 pF1KE4 NNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPY >>NP_001243528 (OMIM: 600986) tripartite motif-containin (736 aa) initn: 1457 init1: 626 opt: 1779 Z-score: 1456.3 bits: 280.1 E(85289): 2.2e-74 Smith-Waterman score: 2102; 42.8% identity (75.3% similar) in 726 aa overlap (24-720:1-722) 10 20 30 40 50 60 pF1KE4 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL .::.:.::.::.:.:.. .::.::: :..:. :..:. NP_001 MKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV 10 20 30 70 80 90 100 pF1KE4 LLTLDDSFNDVGSDNSNQ-----SSPRLRLPS------PSMDKIDRINR------PGWKR : .... :.: :.. :.: : : :. :..::. . :: :: NP_001 L--GQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKR 40 50 60 70 80 90 110 120 130 140 150 160 pF1KE4 NSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPP ..: :.. .::::.:. ::.:::::. :::::.::: .::::::.. .. ::.:.::::: NP_001 GALHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPP 100 110 120 130 140 150 170 180 190 200 210 220 pF1KE4 PQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMY : :.::.: .: :..::::::. ::::: ::::: . :: .:::: ::::.:. :... : NP_001 PLEATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHK-EEVTHY 160 170 180 190 200 210 230 240 250 260 270 280 pF1KE4 CELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNL :. :.: ::.::.. .:..:..: . :::..::.::.:.. :..:... :..:: ::. NP_001 CKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEE 220 230 240 250 260 270 290 300 310 320 330 340 pF1KE4 LMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLL ...:: .:..::::. . : ::::...:.:.::. .. :: ....:..:...:: NP_001 AVRHTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLL 280 290 300 310 320 330 350 360 370 380 390 400 pF1KE4 ENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQ ...::::::::::::::: ::::.::::: :: .:::.:..:::::..::. ...... NP_001 DGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGRE 340 350 360 370 380 390 410 420 430 440 450 pF1KE4 TELLGELSFFSSGIDVPEINEEQSKVYNNALINWH-HPEKDKADSYVLEYRKIN---RDD .:: ::.:. ..: :. ... .:.. .. :. :.. : :..:.:. . . NP_001 MKLLTELNFLRVP-EAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPG 400 410 420 430 440 450 460 470 480 490 500 510 pF1KE4 EMSWNEIE-VCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFD :.. : : ::: .... ...:.:..:::. . . . :... ::::::::. :..: NP_001 PTRWQRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLD 460 470 480 490 500 510 520 530 540 550 560 570 pF1KE4 EKCGYNNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAF . : . :.: .. . :.: :. :::::.:. .: . :.: ..::...:.:. .:: NP_001 SRWGASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWAC 520 530 540 550 560 570 580 590 600 610 620 630 pF1KE4 RVEPYSYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTI :.: ::::::::. .:::: ... :..::::. :::::::.::: ..: ::...:: NP_001 AVDPASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTI 580 590 600 610 620 630 640 650 660 670 680 690 pF1KE4 GMQKFFIPKSPTSSNEPENR-------VLPMPTSIGIFLDCDKGKVNFYDMDQMKCLYER :: :... .. .:. .: ..:.: .:: :: ..:.:.: : ... : : NP_001 GMGKILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLEC 640 650 660 670 680 690 700 710 720 pF1KE4 QVDCSHTLYPAFALMGSGGIQLEEPITAKYLEYQEDM .::: . ::: ..:.:..::.::. .: NP_001 PLDCSGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD 700 710 720 730 >>XP_016857882 (OMIM: 600986) PREDICTED: tripartite moti (746 aa) initn: 1457 init1: 626 opt: 1779 Z-score: 1456.3 bits: 280.1 E(85289): 2.2e-74 Smith-Waterman score: 2110; 42.8% identity (75.4% similar) in 729 aa overlap (21-720:8-732) 10 20 30 40 50 60 pF1KE4 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL :...::.:.::.::.:.:.. .::.::: :..:. :..:. XP_016 MAAKRGTKTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV 10 20 30 40 70 80 90 100 pF1KE4 LLTLDDSFNDVGSDNSNQ-----SSPRLRLPS------PSMDKIDRINR------PGWKR : .... :.: :.. :.: : : :. :..::. . :: :: XP_016 L--GQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKR 50 60 70 80 90 100 110 120 130 140 150 160 pF1KE4 NSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPP ..: :.. .::::.:. ::.:::::. :::::.::: .::::::.. .. ::.:.::::: XP_016 GALHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPP 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE4 PQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMY : :.::.: .: :..::::::. ::::: ::::: . :: .:::: ::::.:. :... : XP_016 PLEATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHK-EEVTHY 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE4 CELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNL :. :.: ::.::.. .:..:..: . :::..::.::.:.. :..:... :..:: ::. XP_016 CKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEE 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE4 LMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLL ...:: .:..::::. . : ::::...:.:.::. .. :: ....:..:...:: XP_016 AVRHTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLL 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE4 ENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQ ...::::::::::::::: ::::.::::: :: .:::.:..:::::..::. ...... XP_016 DGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGRE 350 360 370 380 390 400 410 420 430 440 450 pF1KE4 TELLGELSFFSSGIDVPEINEEQSKVYNNALINWH-HPEKDKADSYVLEYRKIN---RDD .:: ::.:. ..: :. ... .:.. .. :. :.. : :..:.:. . . XP_016 MKLLTELNFLRVP-EAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPG 410 420 430 440 450 460 460 470 480 490 500 510 pF1KE4 EMSWNEIE-VCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFD :.. : : ::: .... ...:.:..:::. . . . :... ::::::::. :..: XP_016 PTRWQRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLD 470 480 490 500 510 520 520 530 540 550 560 570 pF1KE4 EKCGYNNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAF . : . :.: .. . :.: :. :::::.:. .: . :.: ..::...:.:. .:: XP_016 SRWGASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWAC 530 540 550 560 570 580 580 590 600 610 620 630 pF1KE4 RVEPYSYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTI :.: ::::::::. .:::: ... :..::::. :::::::.::: ..: ::...:: XP_016 AVDPASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTI 590 600 610 620 630 640 640 650 660 670 680 690 pF1KE4 GMQKFFIPKSPTSSNEPENR-------VLPMPTSIGIFLDCDKGKVNFYDMDQMKCLYER :: :... .. .:. .: ..:.: .:: :: ..:.:.: : ... : : XP_016 GMGKILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLEC 650 660 670 680 690 700 700 710 720 pF1KE4 QVDCSHTLYPAFALMGSGGIQLEEPITAKYLEYQEDM .::: . ::: ..:.:..::.::. .: XP_016 PLDCSGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD 710 720 730 740 >>NP_001243530 (OMIM: 600986) tripartite motif-containin (746 aa) initn: 1457 init1: 626 opt: 1779 Z-score: 1456.3 bits: 280.1 E(85289): 2.2e-74 Smith-Waterman score: 2109; 42.7% identity (75.3% similar) in 730 aa overlap (20-720:7-732) 10 20 30 40 50 60 pF1KE4 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL : ...::.:.::.::.:.:.. .::.::: :..:. :..:. NP_001 MGAKGNGLTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV 10 20 30 40 70 80 90 100 pF1KE4 LLTLDDSFNDVGSDNSNQ-----SSPRLRLPS------PSMDKIDRINR------PGWKR : .... :.: :.. :.: : : :. :..::. . :: :: NP_001 LG--QQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKR 50 60 70 80 90 100 110 120 130 140 150 160 pF1KE4 NSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPP ..: :.. .::::.:. ::.:::::. :::::.::: .::::::.. .. ::.:.::::: NP_001 GALHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPP 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE4 PQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMY : :.::.: .: :..::::::. ::::: ::::: . :: .:::: ::::.:. :... : NP_001 PLEATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHK-EEVTHY 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE4 CELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNL :. :.: ::.::.. .:..:..: . :::..::.::.:.. :..:... :..:: ::. NP_001 CKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEE 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE4 LMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLL ...:: .:..::::. . : ::::...:.:.::. .. :: ....:..:...:: NP_001 AVRHTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLL 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE4 ENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQ ...::::::::::::::: ::::.::::: :: .:::.:..:::::..::. ...... NP_001 DGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGRE 350 360 370 380 390 400 410 420 430 440 450 pF1KE4 TELLGELSFFSSGIDVPEINEEQSKVYNNALINWH-HPEKDKADSYVLEYRKIN---RDD .:: ::.:. ..: :. ... .:.. .. :. :.. : :..:.:. . . NP_001 MKLLTELNFLRVP-EAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPG 410 420 430 440 450 460 460 470 480 490 500 510 pF1KE4 EMSWNEIE-VCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFD :.. : : ::: .... ...:.:..:::. . . . :... ::::::::. :..: NP_001 PTRWQRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLD 470 480 490 500 510 520 520 530 540 550 560 570 pF1KE4 EKCGYNNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAF . : . :.: .. . :.: :. :::::.:. .: . :.: ..::...:.:. .:: NP_001 SRWGASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWAC 530 540 550 560 570 580 580 590 600 610 620 630 pF1KE4 RVEPYSYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTI :.: ::::::::. .:::: ... :..::::. :::::::.::: ..: ::...:: NP_001 AVDPASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTI 590 600 610 620 630 640 640 650 660 670 680 690 pF1KE4 GMQKFFIPKSPTSSNEPENR-------VLPMPTSIGIFLDCDKGKVNFYDMDQMKCLYER :: :... .. .:. .: ..:.: .:: :: ..:.:.: : ... : : NP_001 GMGKILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLEC 650 660 670 680 690 700 700 710 720 pF1KE4 QVDCSHTLYPAFALMGSGGIQLEEPITAKYLEYQEDM .::: . ::: ..:.:..::.::. .: NP_001 PLDCSGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD 710 720 730 740 >>NP_079334 (OMIM: 600986) tripartite motif-containing p (759 aa) initn: 1474 init1: 626 opt: 1779 Z-score: 1456.2 bits: 280.1 E(85289): 2.3e-74 Smith-Waterman score: 2140; 42.3% identity (75.3% similar) in 749 aa overlap (1-720:1-745) 10 20 30 40 50 60 pF1KE4 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL :.:. .:. : ::. ... ....::.:.::.::.:.:.. .::.::: :..:. :..:. NP_079 MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV 10 20 30 40 50 60 70 80 90 100 pF1KE4 LLTLDDSFNDVGSDNSNQ-----SSPRLRLPS------PSMDKIDRINR------PGWKR : .... :.: :.. :.: : : :. :..::. . :: :: NP_079 LG--QQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKR 70 80 90 100 110 110 120 130 140 150 160 pF1KE4 NSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPP ..: :.. .::::.:. ::.:::::. :::::.::: .::::::.. .. ::.:.::::: NP_079 GALHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPP 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 PQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMY : :.::.: .: :..::::::. ::::: ::::: . :: .:::: ::::.:. :... : NP_079 PLEATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHK-EEVTHY 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE4 CELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNL :. :.: ::.::.. .:..:..: . :::..::.::.:.. :..:... :..:: ::. NP_079 CKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEE 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE4 LMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLL ...:: .:..::::. . : ::::...:.:.::. .. :: ....:..:...:: NP_079 AVRHTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLL 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE4 ENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQ ...::::::::::::::: ::::.::::: :: .:::.:..:::::..::. ...... NP_079 DGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGRE 360 370 380 390 400 410 410 420 430 440 450 pF1KE4 TELLGELSFFSSGIDVPEINEEQSKVYNNALINWH-HPEKDKADSYVLEYRKIN---RDD .:: ::.:. ..: :. ... .:.. .. :. :.. : :..:.:. . . NP_079 MKLLTELNFLRVP-EAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPG 420 430 440 450 460 470 460 470 480 490 500 510 pF1KE4 EMSWNEIE-VCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFD :.. : : ::: .... ...:.:..:::. . . . :... ::::::::. :..: NP_079 PTRWQRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLD 480 490 500 510 520 530 520 530 540 550 560 570 pF1KE4 EKCGYNNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAF . : . :.: .. . :.: :. :::::.:. .: . :.: ..::...:.:. .:: NP_079 SRWGASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWAC 540 550 560 570 580 590 580 590 600 610 620 630 pF1KE4 RVEPYSYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTI :.: ::::::::. .:::: ... :..::::. :::::::.::: ..: ::...:: NP_079 AVDPASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTI 600 610 620 630 640 650 640 650 660 670 680 690 pF1KE4 GMQKFFIPKSPTSSNEPENR-------VLPMPTSIGIFLDCDKGKVNFYDMDQMKCLYER :: :... .. .:. .: ..:.: .:: :: ..:.:.: : ... : : NP_079 GMGKILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLEC 660 670 680 690 700 710 700 710 720 pF1KE4 QVDCSHTLYPAFALMGSGGIQLEEPITAKYLEYQEDM .::: . ::: ..:.:..::.::. .: NP_079 PLDCSGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD 720 730 740 750 728 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 16:40:56 2016 done: Mon Nov 7 16:40:58 2016 Total Scan time: 11.990 Total Display time: 0.220 Function used was FASTA [36.3.4 Apr, 2011]