Result of FASTA (omim) for
pFN21AE1851
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1851, 370 aa
1>>>pF1KE1851 370 - 370 aa - 370 aa
Library: /omim/omim.rfq.tfa
64092750 residues in 91774 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7800+/-0.000289; mu= 20.4877+/- 0.018
mean_var=75.8850+/-14.924, 0's: 0 Z-trim(119.0): 65 B-trim: 0 in 0/52
Lambda= 0.147230
statistics sampled from 33640 (33707) to 33640 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.738), E-opt: 0.2 (0.367), width: 16
Scan time: 4.320
The best scores are: opt bits E(91774)
NP_005421 (OMIM: 164820,615220,615221) proto-oncog ( 370) 2644 570.6 2.2e-162
NP_110380 (OMIM: 165330,273395) proto-oncogene Wnt ( 355) 1136 250.3 5.6e-66
NP_149122 (OMIM: 606359) protein Wnt-3a precursor ( 352) 1120 246.9 5.8e-65
XP_011542621 (OMIM: 606359) protein Wnt-3a isoform ( 446) 1120 247.0 6.9e-65
NP_110388 (OMIM: 158330,603490,611812) protein Wnt ( 351) 1109 244.5 2.9e-64
XP_011539899 (OMIM: 158330,603490,611812) protein ( 373) 1106 243.9 4.8e-64
XP_011539900 (OMIM: 158330,603490,611812) protein ( 296) 1092 240.8 3.2e-63
NP_004616 (OMIM: 228930,276820,601570) protein Wnt ( 349) 981 217.3 4.5e-56
NP_478679 (OMIM: 601967) protein Wnt-7b precursor ( 349) 976 216.3 9.3e-56
XP_011528668 (OMIM: 601967) protein Wnt-7b isoform ( 353) 976 216.3 9.4e-56
NP_057171 (OMIM: 606267) protein Wnt-16 isoform 2 ( 355) 966 214.2 4.1e-55
NP_476509 (OMIM: 606267) protein Wnt-16 isoform 1 ( 365) 966 214.2 4.2e-55
XP_011532393 (OMIM: 228930,276820,601570) protein ( 282) 949 210.4 4.3e-54
XP_005274288 (OMIM: 603699) protein Wnt-11 isoform ( 354) 880 195.9 1.3e-49
NP_004617 (OMIM: 603699) protein Wnt-11 precursor ( 354) 880 195.9 1.3e-49
NP_490645 (OMIM: 606360) protein Wnt-8a isoform 3 ( 351) 876 195.0 2.3e-49
NP_001287868 (OMIM: 606360) protein Wnt-8a isoform ( 369) 876 195.1 2.4e-49
XP_016865314 (OMIM: 606360) protein Wnt-8a isoform ( 391) 876 195.1 2.5e-49
NP_001287867 (OMIM: 606360) protein Wnt-8a isoform ( 386) 871 194.0 5.2e-49
XP_016865313 (OMIM: 606360) protein Wnt-8a isoform ( 408) 871 194.0 5.4e-49
XP_011543541 (OMIM: 603699) protein Wnt-11 isoform ( 364) 855 190.6 5.2e-48
XP_011543540 (OMIM: 603699) protein Wnt-11 isoform ( 364) 855 190.6 5.2e-48
XP_011543542 (OMIM: 603699) protein Wnt-11 isoform ( 364) 855 190.6 5.2e-48
NP_003384 (OMIM: 601396) protein Wnt-8b precursor ( 351) 852 189.9 8e-48
NP_003386 (OMIM: 602863) protein Wnt-9a precursor ( 365) 847 188.9 1.7e-47
NP_003387 (OMIM: 602864) protein Wnt-9b isoform 1 ( 357) 833 185.9 1.3e-46
XP_011523480 (OMIM: 602864) protein Wnt-9b isoform ( 363) 830 185.3 2.1e-46
XP_011542573 (OMIM: 602863) protein Wnt-9a isoform ( 295) 804 179.7 8.3e-45
XP_024304972 (OMIM: 606361) protein Wnt-5b isoform ( 380) 759 170.2 7.4e-42
XP_024304971 (OMIM: 606361) protein Wnt-5b isoform ( 411) 759 170.2 7.9e-42
XP_011541927 (OMIM: 606360) protein Wnt-8a isoform ( 337) 756 169.5 1.1e-41
NP_116031 (OMIM: 606361) protein Wnt-5b precursor ( 359) 746 167.4 4.8e-41
NP_110402 (OMIM: 606361) protein Wnt-5b precursor ( 359) 746 167.4 4.8e-41
XP_024304974 (OMIM: 606361) protein Wnt-5b isoform ( 359) 746 167.4 4.8e-41
XP_024304973 (OMIM: 606361) protein Wnt-5b isoform ( 359) 746 167.4 4.8e-41
XP_024304975 (OMIM: 606361) protein Wnt-5b isoform ( 359) 746 167.4 4.8e-41
XP_024304976 (OMIM: 606361) protein Wnt-5b isoform ( 359) 746 167.4 4.8e-41
XP_024304977 (OMIM: 606361) protein Wnt-5b isoform ( 359) 746 167.4 4.8e-41
NP_004176 (OMIM: 601968,618168) protein Wnt-2b iso ( 372) 746 167.4 5e-41
NP_078613 (OMIM: 601968,618168) protein Wnt-2b iso ( 391) 746 167.5 5.1e-41
XP_011532391 (OMIM: 164975,180700) protein Wnt-5a ( 365) 743 166.8 7.6e-41
XP_011532388 (OMIM: 164975,180700) protein Wnt-5a ( 365) 743 166.8 7.6e-41
XP_006713387 (OMIM: 164975,180700) protein Wnt-5a ( 365) 743 166.8 7.6e-41
XP_016862617 (OMIM: 164975,180700) protein Wnt-5a ( 365) 743 166.8 7.6e-41
XP_011532389 (OMIM: 164975,180700) protein Wnt-5a ( 365) 743 166.8 7.6e-41
XP_011532387 (OMIM: 164975,180700) protein Wnt-5a ( 365) 743 166.8 7.6e-41
XP_011532390 (OMIM: 164975,180700) protein Wnt-5a ( 365) 743 166.8 7.6e-41
NP_001243034 (OMIM: 164975,180700) protein Wnt-5a ( 365) 743 166.8 7.6e-41
NP_003383 (OMIM: 164975,180700) protein Wnt-5a iso ( 380) 743 166.8 7.8e-41
XP_016862616 (OMIM: 164975,180700) protein Wnt-5a ( 394) 743 166.8 8e-41
>>NP_005421 (OMIM: 164820,615220,615221) proto-oncogene (370 aa)
initn: 2644 init1: 2644 opt: 2644 Z-score: 3037.0 bits: 570.6 E(91774): 2.2e-162
Smith-Waterman score: 2644; 100.0% identity (100.0% similar) in 370 aa overlap (1-370:1-370)
10 20 30 40 50 60
pF1KE1 MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 CRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 CRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 GREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 AVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 YSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNC
310 320 330 340 350 360
370
pF1KE1 THTRVLHECL
::::::::::
NP_005 THTRVLHECL
370
>>NP_110380 (OMIM: 165330,273395) proto-oncogene Wnt-3 p (355 aa)
initn: 1107 init1: 597 opt: 1136 Z-score: 1306.1 bits: 250.3 E(91774): 5.6e-66
Smith-Waterman score: 1136; 46.0% identity (71.8% similar) in 337 aa overlap (34-369:26-354)
10 20 30 40 50 60
pF1KE1 WALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPSLQL
::... . :.: . : .: :.
NP_110 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGS-----QPLLCGSIPG
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 LSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGP-HLFGKIVNRGCR
: :: :. :. :. ::. :.. ...::. :::.::::: : .:: ..... :
NP_110 LVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATR
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE1 ETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGR
:.::. ::.::::. .:.:::.::. : :: ...:: : :.:::::.. ::: : .:
NP_110 ESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSR
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE1 EFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLRAV
::.:. :. : : :: :::::::::....:. .:::::.:::: :.::: : .::.
NP_110 EFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAI
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE1 GDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCTYS
:: :.:..:.::... ..: ::. . :. . :::. .::::.:.::::: .
NP_110 GDFLKDKYDSASEMVV---EKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPN
240 250 260 270 280
310 320 330 340 350 360
pF1KE1 GRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTH
. :. :: :.:: .: ..:::.:::::::: :::.. :.:.: :::::.:::..: .
NP_110 PETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIR
290 300 310 320 330 340
370
pF1KE1 TRVLHECL
.: :
NP_110 IYDVHTCK
350
>>NP_149122 (OMIM: 606359) protein Wnt-3a precursor [Hom (352 aa)
initn: 1089 init1: 574 opt: 1120 Z-score: 1287.8 bits: 246.9 E(91774): 5.8e-65
Smith-Waterman score: 1120; 44.5% identity (70.7% similar) in 355 aa overlap (16-369:7-351)
10 20 30 40 50 60
pF1KE1 MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPS
.: : .: :: .: ::... . ..: . : .: :
NP_149 MAPLGYFLLLCSLKQAL--GSYPIWWSLAVGPQYSSLGS-----QPILCAS
10 20 30 40
70 80 90 100 110
pF1KE1 LQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGP-HLFGKIVNR
. : :: :. :. :. ::. :.. ...::. :::.::::: :. .:: ....
NP_149 IPGLVPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDK
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE1 GCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRL
. ::.::. ::.::::. .:.:::.::. : :. :..: : :.:::::..:.:: .
NP_149 ATRESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGM
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE1 FGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTL
.:::.:. :. : : :: ::::::: .. :.:. .:::::.:::: :.::: : .
NP_149 VSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDF
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE1 RAVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFC
::.:: :.:..:.::... . .: ::. . :.:. : :. .::::.: :::::
NP_149 RAIGDFLKDKYDSASEMVVEK---HRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFC
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE1 TYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRN
. . :. :: :.:: :: ..:::.:::::::: .:..: :.: :.:::::.:::..
NP_149 EPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQE
290 300 310 320 330 340
360 370
pF1KE1 CTHTRVLHECL
::.. .: :
NP_149 CTRVYDVHTCK
350
>>XP_011542621 (OMIM: 606359) protein Wnt-3a isoform X1 (446 aa)
initn: 1089 init1: 574 opt: 1120 Z-score: 1286.5 bits: 247.0 E(91774): 6.9e-65
Smith-Waterman score: 1120; 44.5% identity (70.7% similar) in 355 aa overlap (16-369:7-351)
10 20 30 40 50 60
pF1KE1 MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPS
.: : .: :: .: ::... . ..: . : .: :
XP_011 MAPLGYFLLLCSLKQAL--GSYPIWWSLAVGPQYSSLGS-----QPILCAS
10 20 30 40
70 80 90 100 110
pF1KE1 LQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGP-HLFGKIVNR
. : :: :. :. :. ::. :.. ...::. :::.::::: :. .:: ....
XP_011 IPGLVPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDK
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE1 GCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRL
. ::.::. ::.::::. .:.:::.::. : :. :..: : :.:::::..:.:: .
XP_011 ATRESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGM
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE1 FGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTL
.:::.:. :. : : :: ::::::: .. :.:. .:::::.:::: :.::: : .
XP_011 VSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDF
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE1 RAVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFC
::.:: :.:..:.::... . .: ::. . :.:. : :. .::::.: :::::
XP_011 RAIGDFLKDKYDSASEMVVEK---HRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFC
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE1 TYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRN
. . :. :: :.:: :: ..:::.:::::::: .:..: :.: :.:::::.:::..
XP_011 EPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQE
290 300 310 320 330 340
360 370
pF1KE1 CTHTRVLHECL
::.. .: :
XP_011 CTRVYDVHTCKPCHSWATGREGRRRWSTLGCGPRDGCLRTGHSGPCRSLAWIWSPGSQGH
350 360 370 380 390 400
>>NP_110388 (OMIM: 158330,603490,611812) protein Wnt-4 p (351 aa)
initn: 1111 init1: 413 opt: 1109 Z-score: 1275.2 bits: 244.5 E(91774): 2.9e-64
Smith-Waterman score: 1113; 45.4% identity (70.6% similar) in 357 aa overlap (16-369:12-350)
10 20 30 40 50 60
pF1KE1 MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPS
::..:.. :: :.: : . ::.. ... .. . .
NP_110 MSPRSCLRSLRLLVFAVFSAA-ASN-----WLYLAKLSSVGSISEEETCE-----K
10 20 30 40
70 80 90 100 110 120
pF1KE1 LQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRG
:. : ..: .. ..: .. :: : : :..::..::::::::: : . .:::.:..:
NP_110 LKGLIQRQVQMCKRNLEVMDSVRRGAQLAIEECQYQFRNRRWNCSTLDSLPVFGKVVTQG
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE1 CRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLF
::.::..::.::::. .:.:.:: : .:.: :: .: . ..:.:::::: .: :
NP_110 TREAAFVYAISSAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAF
110 120 130 140 150 160
190 200 210 220 230
pF1KE1 GREFVDSGEKGRDL---RFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLP
.. ::: :... : ::::::::::: .....:: ::::::.:::: :.::: .:
NP_110 SQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVECKCHGVSGSCEVKTCWRAVP
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE1 TLRAVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPN
.: :: .:...::::..: ::.:: : :.. :: . .::::.: ::.
NP_110 PFRQVGHALKEKFDGATEVEPRRVGSSRA-------LVPRNAQFKPHTDEDLVYLEPSPD
230 240 250 260 270
300 310 320 330 340 350
pF1KE1 FCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSC
:: . : :. :: ::.::..: :.::::::::::: .: ...:::.: ::::: :.:
NP_110 FCEQDMRSGVLGTRGRTCNKTSKAIDGCELLCCGRGFHTAQVELAERCSCKFHWCCFVKC
280 290 300 310 320 330
360 370
pF1KE1 RNCTHTRVLHECL
:.: . :: :
NP_110 RQCQRLVELHTCR
340 350
>>XP_011539899 (OMIM: 158330,603490,611812) protein Wnt- (373 aa)
initn: 1091 init1: 413 opt: 1106 Z-score: 1271.4 bits: 243.9 E(91774): 4.8e-64
Smith-Waterman score: 1106; 48.7% identity (72.8% similar) in 312 aa overlap (61-369:68-372)
40 50 60 70 80 90
pF1KE1 SGRWWGIVNVASSTNLLTDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAV
:. : ..: .. ..: .. :: : : :.
XP_011 YEGEDTGHIPRYLAKLSSVGSISEEETCEKLKGLIQRQVQMCKRNLEVMDSVRRGAQLAI
40 50 60 70 80 90
100 110 120 130 140 150
pF1KE1 RECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIES
.::..::::::::: : . .:::.:..: ::.::..::.::::. .:.:.:: : .:.
XP_011 EECQYQFRNRRWNCSTLDSLPVFGKVVTQGTREAAFVYAISSAGVAFAVTRACSSGELEK
100 110 120 130 140 150
160 170 180 190 200
pF1KE1 CTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDL---RFLMNLHNNEAGR
: :: .: . ..:.:::::: .: :.. ::: :... : :::::::::::
XP_011 CGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGR
160 170 180 190 200 210
210 220 230 240 250 260
pF1KE1 TTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRAS
.....:: ::::::.:::: :.::: .: .: :: .:...::::..: ::.::
XP_011 KAILTHMRVECKCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRA-
220 230 240 250 260 270
270 280 290 300 310 320
pF1KE1 RAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCEL
: :.. :: . .::::.: ::.:: . : :. :: ::.::..: :.:::::
XP_011 ------LVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTCNKTSKAIDGCEL
280 290 300 310 320 330
330 340 350 360 370
pF1KE1 LCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL
:::::: .: ...:::.: ::::: :.::.: . :: :
XP_011 LCCGRGFHTAQVELAERCSCKFHWCCFVKCRQCQRLVELHTCR
340 350 360 370
>>XP_011539900 (OMIM: 158330,603490,611812) protein Wnt- (296 aa)
initn: 1111 init1: 413 opt: 1092 Z-score: 1256.6 bits: 240.8 E(91774): 3.2e-63
Smith-Waterman score: 1092; 49.3% identity (72.8% similar) in 302 aa overlap (71-369:1-295)
50 60 70 80 90 100
pF1KE1 ASSTNLLTDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNR
. ..: .. :: : : :..::..:::::
XP_011 MCKRNLEVMDSVRRGAQLAIEECQYQFRNR
10 20 30
110 120 130 140 150 160
pF1KE1 RWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGP
:::: : . .:::.:..: ::.::..::.::::. .:.:.:: : .:.: :: .:
XP_011 RWNCSTLDSLPVFGKVVTQGTREAAFVYAISSAGVAFAVTRACSSGELEKCGCDRTVHGV
40 50 60 70 80 90
170 180 190 200 210
pF1KE1 GGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDL---RFLMNLHNNEAGRTTVFSEMRQE
. ..:.:::::: .: :.. ::: :... : ::::::::::: .....:: :
XP_011 SPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVE
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE1 CKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPE
:::::.:::: :.::: .: .: :: .:...::::..: ::.:: : :.
XP_011 CKCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRA-------LVPR
160 170 180 190 200
280 290 300 310 320 330
pF1KE1 DPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTR
. :: . .::::.: ::.:: . : :. :: ::.::..: :.::::::::::: .:
XP_011 NAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTCNKTSKAIDGCELLCCGRGFHTA
210 220 230 240 250 260
340 350 360 370
pF1KE1 TQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL
...:::.: ::::: :.::.: . :: :
XP_011 QVELAERCSCKFHWCCFVKCRQCQRLVELHTCR
270 280 290
>>NP_004616 (OMIM: 228930,276820,601570) protein Wnt-7a (349 aa)
initn: 699 init1: 371 opt: 981 Z-score: 1128.3 bits: 217.3 E(91774): 4.5e-56
Smith-Waterman score: 981; 42.9% identity (70.5% similar) in 308 aa overlap (64-369:44-348)
40 50 60 70 80 90
pF1KE1 WWGIVNVASSTNLLTDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVREC
:. .:: . .. : . .. : : .. ::
NP_004 LSLGMVYLRIGGFSSVVALGASIICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDEC
20 30 40 50 60 70
100 110 120 130 140 150
pF1KE1 KWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTC
..:::: :::: . .::: .. : ::.:: .:: .:::.:... .:..:.. .: :
NP_004 QFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAACTQGNLSDCGC
80 90 100 110 120 130
160 170 180 190 200 210
pF1KE1 DYRRRGPGGPD--WHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVF
: ...: : :.::::: .: .: :.. :::. : .. : ::::::::::: .
NP_004 DKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILE
140 150 160 170 180 190
220 230 240 250 260 270
pF1KE1 SEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRASRAEL
.:. ::::::.:::::..::: :: .: .: ::.:... : .: :.: : .: .
NP_004 ENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHV-EPVRAS-RNKRPTF
200 210 220 230 240 250
280 290 300 310 320 330
pF1KE1 LRLEPEDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCG
:... . ... : ::::.:::::.: . :..:: :::::...: .::.:.:::
NP_004 LKIK-KPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCG
260 270 280 290 300 310
340 350 360 370
pF1KE1 RGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL
::. :. . .::: :::::.:.: .:.. .. :
NP_004 RGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK
320 330 340
>>NP_478679 (OMIM: 601967) protein Wnt-7b precursor [Hom (349 aa)
initn: 706 init1: 378 opt: 976 Z-score: 1122.6 bits: 216.3 E(91774): 9.3e-56
Smith-Waterman score: 976; 42.5% identity (70.1% similar) in 308 aa overlap (64-369:44-348)
40 50 60 70 80 90
pF1KE1 WWGIVNVASSTNLLTDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVREC
:. .:: . .. : . .. : : .. ::
NP_478 LCFGVLYVKLGALSSVVALGANIICNKIPGLAPRQRAICQSRPDAIIVIGEGAQMGINEC
20 30 40 50 60 70
100 110 120 130 140 150
pF1KE1 KWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTC
..::: :::: . .::. . : ::.:: .:::.:::.:.:. .::.:.. .: :
NP_478 QYQFRFGRWNCSALGEKTVFGQELRVGSREAAFTYAITAAGVAHAVTAACSQGNLSNCGC
80 90 100 110 120 130
160 170 180 190 200 210
pF1KE1 DYRRRG--PGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVF
: ...: . :.::::: .. .: :.:.:::. : .. : ::::::::::: ..
NP_478 DREKQGYYNQAEGWKWGGCSADVRYGIDFSRRFVDAREIKKNARRLMNLHNNEAGRKVLE
140 150 160 170 180 190
220 230 240 250 260 270
pF1KE1 SEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRASRAEL
..:. ::::::.:::::..::: :: .: :: .:......: .: :.: : . .
NP_478 DRMQLECKCHGVSGSCTTKTCWTTLPKFREVGHLLKEKYNAAVQVEV-VRAS-RLRQPTF
200 210 220 230 240 250
280 290 300 310 320 330
pF1KE1 LRLEPEDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCG
::.. . ... : ::::.:::::.: .. :..:: :: :: .::. :::. .:::
NP_478 LRIK-QLRSYQKPMETDLVYIEKSPNYCEEDAATGSVGTQGRLCNRTSPGADGCDTMCCG
260 270 280 290 300 310
340 350 360 370
pF1KE1 RGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL
::. :. . .::: ::::: :.: .:.. . :
NP_478 RGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTCK
320 330 340
>>XP_011528668 (OMIM: 601967) protein Wnt-7b isoform X1 (353 aa)
initn: 706 init1: 378 opt: 976 Z-score: 1122.5 bits: 216.3 E(91774): 9.4e-56
Smith-Waterman score: 976; 42.5% identity (70.1% similar) in 308 aa overlap (64-369:48-352)
40 50 60 70 80 90
pF1KE1 WWGIVNVASSTNLLTDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVREC
:. .:: . .. : . .. : : .. ::
XP_011 IFLLLSSGSYLALSSVVALGANIICNKIPGLAPRQRAICQSRPDAIIVIGEGAQMGINEC
20 30 40 50 60 70
100 110 120 130 140 150
pF1KE1 KWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTC
..::: :::: . .::. . : ::.:: .:::.:::.:.:. .::.:.. .: :
XP_011 QYQFRFGRWNCSALGEKTVFGQELRVGSREAAFTYAITAAGVAHAVTAACSQGNLSNCGC
80 90 100 110 120 130
160 170 180 190 200 210
pF1KE1 DYRRRG--PGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVF
: ...: . :.::::: .. .: :.:.:::. : .. : ::::::::::: ..
XP_011 DREKQGYYNQAEGWKWGGCSADVRYGIDFSRRFVDAREIKKNARRLMNLHNNEAGRKVLE
140 150 160 170 180 190
220 230 240 250 260 270
pF1KE1 SEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRASRAEL
..:. ::::::.:::::..::: :: .: :: .:......: .: :.: : . .
XP_011 DRMQLECKCHGVSGSCTTKTCWTTLPKFREVGHLLKEKYNAAVQVEV-VRAS-RLRQPTF
200 210 220 230 240 250
280 290 300 310 320 330
pF1KE1 LRLEPEDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCG
::.. . ... : ::::.:::::.: .. :..:: :: :: .::. :::. .:::
XP_011 LRIK-QLRSYQKPMETDLVYIEKSPNYCEEDAATGSVGTQGRLCNRTSPGADGCDTMCCG
260 270 280 290 300 310
340 350 360 370
pF1KE1 RGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL
::. :. . .::: ::::: :.: .:.. . :
XP_011 RGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTCK
320 330 340 350
370 residues in 1 query sequences
64092750 residues in 91774 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Jul 16 15:55:58 2019 done: Tue Jul 16 15:55:58 2019
Total Scan time: 4.320 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]