FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB0120, 1529 aa 1>>>pF1KB0120 1529 - 1529 aa - 1529 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.4525+/-0.00082; mu= 7.8404+/- 0.050 mean_var=354.5331+/-72.853, 0's: 0 Z-trim(111.9): 732 B-trim: 822 in 1/48 Lambda= 0.068115 statistics sampled from 19703 (20594) to 19703 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.568), E-opt: 0.2 (0.241), width: 16 Scan time: 12.660 The best scores are: opt bits E(85289) NP_004778 (OMIM: 603746) slit homolog 2 protein is (1529) 10738 1072.4 0 XP_005248268 (OMIM: 603746) PREDICTED: slit homolo (1533) 10720 1070.6 0 NP_001276065 (OMIM: 603746) slit homolog 2 protein (1521) 10657 1064.4 0 NP_001276064 (OMIM: 603746) slit homolog 2 protein (1525) 10639 1062.7 0 XP_016864334 (OMIM: 603746) PREDICTED: slit homolo (1495) 10329 1032.2 0 XP_011512211 (OMIM: 603746) PREDICTED: slit homolo (1499) 10311 1030.4 0 XP_011512212 (OMIM: 603746) PREDICTED: slit homolo (1159) 8040 807.1 0 NP_001258875 (OMIM: 603745) slit homolog 3 protein (1530) 7467 751.0 1.7e-215 NP_003052 (OMIM: 603742) slit homolog 1 protein pr (1534) 7433 747.6 1.8e-214 NP_003053 (OMIM: 603745) slit homolog 3 protein is (1523) 6287 635.0 1.4e-180 XP_016865268 (OMIM: 603745) PREDICTED: slit homolo (1460) 6074 614.0 2.7e-174 XP_006714049 (OMIM: 603746) PREDICTED: slit homolo (1509) 5716 578.9 1.1e-163 XP_016883196 (OMIM: 118450,187500,601920) PREDICTE (1059) 940 109.3 1.7e-22 NP_000205 (OMIM: 118450,187500,601920) protein jag (1218) 940 109.4 1.8e-22 NP_004548 (OMIM: 164951) neurogenic locus notch ho (2003) 868 102.6 3.3e-20 XP_005259981 (OMIM: 125310,130720,600276,615293) P (2269) 767 92.8 3.4e-17 NP_000426 (OMIM: 125310,130720,600276,615293) neur (2321) 767 92.8 3.5e-17 NP_005609 (OMIM: 606582) delta-like protein 1 prec ( 723) 740 89.4 1.1e-16 NP_001186930 (OMIM: 102500,600275,610205) neurogen (1235) 741 89.9 1.4e-16 XP_011539822 (OMIM: 102500,600275,610205) PREDICTE (2432) 741 90.3 2.1e-16 XP_005270958 (OMIM: 102500,600275,610205) PREDICTE (2432) 741 90.3 2.1e-16 XP_016856862 (OMIM: 102500,600275,610205) PREDICTE (2432) 741 90.3 2.1e-16 XP_016856861 (OMIM: 102500,600275,610205) PREDICTE (2455) 741 90.3 2.1e-16 XP_011539821 (OMIM: 102500,600275,610205) PREDICTE (2467) 741 90.3 2.1e-16 NP_077719 (OMIM: 102500,600275,610205) neurogenic (2471) 741 90.3 2.1e-16 NP_060087 (OMIM: 109730,190198,616028) neurogenic (2555) 731 89.3 4.3e-16 NP_001244895 (OMIM: 172870,600105,604210,613835) p ( 870) 712 86.8 8.4e-16 NP_061947 (OMIM: 605185,616589) delta-like protein ( 685) 699 85.4 1.8e-15 XP_005266991 (OMIM: 606582) PREDICTED: delta-like ( 524) 642 79.6 7.4e-14 NP_699197 (OMIM: 611691) sushi, von Willebrand fac (3571) 634 80.0 3.8e-13 XP_011516858 (OMIM: 219730,609720,616220) PREDICTE (1276) 620 78.0 5.5e-13 NP_775960 (OMIM: 219730,609720,616220) protein cru (1285) 620 78.0 5.5e-13 XP_011516859 (OMIM: 219730,609720,616220) PREDICTE (1220) 599 75.9 2.3e-12 XP_011516860 (OMIM: 219730,609720,616220) PREDICTE (1220) 599 75.9 2.3e-12 NP_982353 (OMIM: 277300,602768) delta-like protein ( 587) 561 71.7 2e-11 NP_058637 (OMIM: 277300,602768) delta-like protein ( 618) 561 71.8 2e-11 NP_660142 (OMIM: 602570) protein jagged-2 isoform (1200) 566 72.7 2.1e-11 NP_002217 (OMIM: 602570) protein jagged-2 isoform (1238) 566 72.7 2.1e-11 XP_016859269 (OMIM: 616634) PREDICTED: sushi, nido (1309) 556 71.7 4.4e-11 XP_016859268 (OMIM: 616634) PREDICTED: sushi, nido (1309) 556 71.7 4.4e-11 XP_016859270 (OMIM: 616634) PREDICTED: sushi, nido (1309) 556 71.7 4.4e-11 XP_016859267 (OMIM: 616634) PREDICTED: sushi, nido (1309) 556 71.7 4.4e-11 XP_011509236 (OMIM: 616634) PREDICTED: sushi, nido (1315) 556 71.7 4.4e-11 XP_011509235 (OMIM: 616634) PREDICTED: sushi, nido (1351) 556 71.7 4.5e-11 XP_011509234 (OMIM: 616634) PREDICTED: sushi, nido (1404) 556 71.8 4.6e-11 NP_001073906 (OMIM: 616634) sushi, nidogen and EGF (1413) 556 71.8 4.6e-11 XP_016859265 (OMIM: 616634) PREDICTED: sushi, nido (1420) 556 71.8 4.6e-11 XP_016859264 (OMIM: 616634) PREDICTED: sushi, nido (1425) 556 71.8 4.6e-11 XP_016859263 (OMIM: 616634) PREDICTED: sushi, nido (1434) 556 71.8 4.6e-11 XP_011509233 (OMIM: 616634) PREDICTED: sushi, nido (1437) 556 71.8 4.6e-11 >>NP_004778 (OMIM: 603746) slit homolog 2 protein isofor (1529 aa) initn: 10738 init1: 10738 opt: 10738 Z-score: 5726.9 bits: 1072.4 E(85289): 0 Smith-Waterman score: 10738; 100.0% identity (100.0% similar) in 1529 aa overlap (1-1529:1-1529) 10 20 30 40 50 60 pF1KB0 MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 DLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 LLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 TLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 HLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 HLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 TITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 TELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB0 AIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 AIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB0 KEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB0 NNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 NNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB0 MFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB0 LLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB0 CSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 CSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLT 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB0 LIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVV 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB0 PEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTT 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB0 PSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHA 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB0 CISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 CISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNY 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KB0 TCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDC 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KB0 QDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRI 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KB0 NEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 NEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYK 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KB0 GDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGN 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KB0 PKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDF 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KB0 QKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKC 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KB0 VHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSS 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KB0 GYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRR 1450 1460 1470 1480 1490 1500 1510 1520 pF1KB0 KYSFECTDGSSFVDEVEKVVKCGCTRCVS ::::::::::::::::::::::::::::: NP_004 KYSFECTDGSSFVDEVEKVVKCGCTRCVS 1510 1520 >>XP_005248268 (OMIM: 603746) PREDICTED: slit homolog 2 (1533 aa) initn: 9001 init1: 9001 opt: 10720 Z-score: 5717.3 bits: 1070.6 E(85289): 0 Smith-Waterman score: 10720; 99.7% identity (99.7% similar) in 1533 aa overlap (1-1529:1-1533) 10 20 30 40 50 60 pF1KB0 MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 DLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 LLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 TLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPS 190 200 210 220 230 240 250 260 270 280 290 pF1KB0 HLRGHNVAEVQKREFVCS----GHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPT :::::::::::::::::: :::::::::::::::::::::::::::::::::::::: XP_005 HLRGHNVAEVQKREFVCSDEEEGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPT 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB0 NLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLY 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB0 GNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTF 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB0 SPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKF 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB0 RCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTA 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB0 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB0 VQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSL 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB0 STLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 STLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGN 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB0 DDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNY 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB0 KHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGND 790 800 810 820 830 840 840 850 860 870 880 890 pF1KB0 ISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKL 850 860 870 880 890 900 900 910 920 930 940 950 pF1KB0 LLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDV 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KB0 PIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDG 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KB0 INNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 INNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDID 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KB0 FDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQC 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KB0 IVRINEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IVRINEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGI 1150 1160 1170 1180 1190 1200 1200 1210 1220 1230 1240 1250 pF1KB0 LLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSV 1210 1220 1230 1240 1250 1260 1260 1270 1280 1290 1300 1310 pF1KB0 DGGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DGGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSE 1270 1280 1290 1300 1310 1320 1320 1330 1340 1350 1360 1370 pF1KB0 LQDFQKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LQDFQKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCL 1330 1340 1350 1360 1370 1380 1380 1390 1400 1410 1420 1430 pF1KB0 GNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYC 1390 1400 1410 1420 1430 1440 1440 1450 1460 1470 1480 1490 pF1KB0 ECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLR 1450 1460 1470 1480 1490 1500 1500 1510 1520 pF1KB0 SKRRKYSFECTDGSSFVDEVEKVVKCGCTRCVS ::::::::::::::::::::::::::::::::: XP_005 SKRRKYSFECTDGSSFVDEVEKVVKCGCTRCVS 1510 1520 1530 >>NP_001276065 (OMIM: 603746) slit homolog 2 protein iso (1521 aa) initn: 7459 init1: 7459 opt: 10657 Z-score: 5683.9 bits: 1064.4 E(85289): 0 Smith-Waterman score: 10657; 99.5% identity (99.5% similar) in 1529 aa overlap (1-1529:1-1521) 10 20 30 40 50 60 pF1KB0 MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 DLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 LLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 TLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 HLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 TITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 TELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB0 AIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCS- 430 440 450 460 470 490 500 510 520 530 540 pF1KB0 KEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRL ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 -------GTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRL 480 490 500 510 520 530 550 560 570 580 590 600 pF1KB0 NNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHK 540 550 560 570 580 590 610 620 630 640 650 660 pF1KB0 MFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLN 600 610 620 630 640 650 670 680 690 700 710 720 pF1KB0 LLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNS 660 670 680 690 700 710 730 740 750 760 770 780 pF1KB0 CSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLT 720 730 740 750 760 770 790 800 810 820 830 840 pF1KB0 LIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVV 780 790 800 810 820 830 850 860 870 880 890 900 pF1KB0 PEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTT 840 850 860 870 880 890 910 920 930 940 950 960 pF1KB0 PSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHA 900 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KB0 CISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNY 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KB0 TCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDC 1020 1030 1040 1050 1060 1070 1090 1100 1110 1120 1130 1140 pF1KB0 QDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRI 1080 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KB0 NEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYK 1140 1150 1160 1170 1180 1190 1210 1220 1230 1240 1250 1260 pF1KB0 GDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGN 1200 1210 1220 1230 1240 1250 1270 1280 1290 1300 1310 1320 pF1KB0 PKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDF 1260 1270 1280 1290 1300 1310 1330 1340 1350 1360 1370 1380 pF1KB0 QKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKC 1320 1330 1340 1350 1360 1370 1390 1400 1410 1420 1430 1440 pF1KB0 VHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSS 1380 1390 1400 1410 1420 1430 1450 1460 1470 1480 1490 1500 pF1KB0 GYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRR 1440 1450 1460 1470 1480 1490 1510 1520 pF1KB0 KYSFECTDGSSFVDEVEKVVKCGCTRCVS ::::::::::::::::::::::::::::: NP_001 KYSFECTDGSSFVDEVEKVVKCGCTRCVS 1500 1510 1520 >>NP_001276064 (OMIM: 603746) slit homolog 2 protein iso (1525 aa) initn: 9183 init1: 7459 opt: 10639 Z-score: 5674.3 bits: 1062.7 E(85289): 0 Smith-Waterman score: 10639; 99.2% identity (99.2% similar) in 1533 aa overlap (1-1529:1-1525) 10 20 30 40 50 60 pF1KB0 MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 DLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 LLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 TLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPS 190 200 210 220 230 240 250 260 270 280 290 pF1KB0 HLRGHNVAEVQKREFVCS----GHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPT :::::::::::::::::: :::::::::::::::::::::::::::::::::::::: NP_001 HLRGHNVAEVQKREFVCSDEEEGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPT 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB0 NLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLY 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB0 GNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTF 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB0 SPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKF 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB0 RCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTA ::: ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RCS--------GTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTA 490 500 510 520 530 540 550 560 570 580 590 pF1KB0 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN 540 550 560 570 580 590 600 610 620 630 640 650 pF1KB0 VQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSL 600 610 620 630 640 650 660 670 680 690 700 710 pF1KB0 STLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGN 660 670 680 690 700 710 720 730 740 750 760 770 pF1KB0 DDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNY 720 730 740 750 760 770 780 790 800 810 820 830 pF1KB0 KHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGND 780 790 800 810 820 830 840 850 860 870 880 890 pF1KB0 ISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKL 840 850 860 870 880 890 900 910 920 930 940 950 pF1KB0 LLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDV 900 910 920 930 940 950 960 970 980 990 1000 1010 pF1KB0 PIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDG 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 pF1KB0 INNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 INNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDID 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 pF1KB0 FDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQC 1080 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 pF1KB0 IVRINEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVRINEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGI 1140 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 pF1KB0 LLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSV 1200 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 pF1KB0 DGGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSE 1260 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 pF1KB0 LQDFQKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQDFQKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCL 1320 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 pF1KB0 GNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYC 1380 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 pF1KB0 ECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLR 1440 1450 1460 1470 1480 1490 1500 1510 1520 pF1KB0 SKRRKYSFECTDGSSFVDEVEKVVKCGCTRCVS ::::::::::::::::::::::::::::::::: NP_001 SKRRKYSFECTDGSSFVDEVEKVVKCGCTRCVS 1500 1510 1520 >>XP_016864334 (OMIM: 603746) PREDICTED: slit homolog 2 (1495 aa) initn: 10325 init1: 10325 opt: 10329 Z-score: 5509.8 bits: 1032.2 E(85289): 0 Smith-Waterman score: 10329; 99.3% identity (99.5% similar) in 1484 aa overlap (50-1529:12-1495) 20 30 40 50 60 70 pF1KB0 LNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL----DLNGNNITRITKTDF :..: : :: ::::::::::::::: XP_016 MPGASETPLCSPESINGVTLRLPASRDLNGNNITRITKTDF 10 20 30 40 80 90 100 110 120 130 pF1KB0 AGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLS 50 60 70 80 90 100 140 150 160 170 180 190 pF1KB0 ENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASF 110 120 130 140 150 160 200 210 220 230 240 250 pF1KB0 NHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREF 170 180 190 200 210 220 260 270 280 290 300 310 pF1KB0 VCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVI 230 240 250 260 270 280 320 330 340 350 360 370 pF1KB0 PPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQ 290 300 310 320 330 340 380 390 400 410 420 430 pF1KB0 LLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICD 350 360 370 380 390 400 440 450 460 470 480 490 pF1KB0 CHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSK 410 420 430 440 450 460 500 510 520 530 540 550 pF1KB0 LSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFK 470 480 490 500 510 520 560 570 580 590 600 610 pF1KB0 KLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRS 530 540 550 560 570 580 620 630 640 650 660 670 pF1KB0 NRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWL 590 600 610 620 630 640 680 690 700 710 720 730 pF1KB0 GEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTECTCLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTECTCLD 650 660 670 680 690 700 740 750 760 770 780 790 pF1KB0 TVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNQ 710 720 730 740 750 760 800 810 820 830 840 850 pF1KB0 SFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLA 770 780 790 800 810 820 860 870 880 890 900 910 pF1KB0 IGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPVDVNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPVDVNI 830 840 850 860 870 880 920 930 940 950 960 970 pF1KB0 LAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLK 890 900 910 920 930 940 980 990 1000 1010 1020 1030 pF1KB0 EGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEE 950 960 970 980 990 1000 1040 1050 1060 1070 1080 1090 pF1KB0 KLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAV 1010 1020 1030 1040 1050 1060 1100 1110 1120 1130 1140 1150 pF1KB0 NGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEK 1070 1080 1090 1100 1110 1120 1160 1170 1180 1190 1200 1210 pF1KB0 CEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVELYRGRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVELYRGRV 1130 1140 1150 1160 1170 1180 1220 1230 1240 1250 1260 1270 pF1KB0 RASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQSTLNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQSTLNF 1190 1200 1210 1220 1230 1240 1280 1290 1300 1310 1320 1330 pF1KB0 DSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILPGCEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILPGCEP 1250 1260 1270 1280 1290 1300 1340 1350 1360 1370 1380 1390 pF1KB0 CHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSC 1310 1320 1330 1340 1350 1360 1400 1410 1420 1430 1440 1450 pF1KB0 KCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREISCRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREISCRG 1370 1380 1390 1400 1410 1420 1460 1470 1480 1490 1500 1510 pF1KB0 ERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGSSFVDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGSSFVDE 1430 1440 1450 1460 1470 1480 1520 pF1KB0 VEKVVKCGCTRCVS :::::::::::::: XP_016 VEKVVKCGCTRCVS 1490 >>XP_011512211 (OMIM: 603746) PREDICTED: slit homolog 2 (1499 aa) initn: 9001 init1: 9001 opt: 10311 Z-score: 5500.2 bits: 1030.4 E(85289): 0 Smith-Waterman score: 10311; 99.1% identity (99.2% similar) in 1488 aa overlap (50-1529:12-1499) 20 30 40 50 60 70 pF1KB0 LNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL----DLNGNNITRITKTDF :..: : :: ::::::::::::::: XP_011 MPGASETPLCSPESINGVTLRLPASRDLNGNNITRITKTDF 10 20 30 40 80 90 100 110 120 130 pF1KB0 AGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLS 50 60 70 80 90 100 140 150 160 170 180 190 pF1KB0 ENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASF 110 120 130 140 150 160 200 210 220 230 240 250 pF1KB0 NHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREF 170 180 190 200 210 220 260 270 280 290 300 310 pF1KB0 VCS----GHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNT ::: ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VCSDEEEGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNT 230 240 250 260 270 280 320 330 340 350 360 370 pF1KB0 IKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGL 290 300 310 320 330 340 380 390 400 410 420 430 pF1KB0 FSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNP 350 360 370 380 390 400 440 450 460 470 480 490 pF1KB0 FICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTED 410 420 430 440 450 460 500 510 520 530 540 550 pF1KB0 YRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEAT 470 480 490 500 510 520 560 570 580 590 600 610 pF1KB0 GIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTL 530 540 550 560 570 580 620 630 640 650 660 670 pF1KB0 MLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCY 590 600 610 620 630 640 680 690 700 710 720 730 pF1KB0 LAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTEC 650 660 670 680 690 700 740 750 760 770 780 790 pF1KB0 TCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRIST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRIST 710 720 730 740 750 760 800 810 820 830 840 850 pF1KB0 LSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSAL 770 780 790 800 810 820 860 870 880 890 900 910 pF1KB0 SHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPV 830 840 850 860 870 880 920 930 940 950 960 970 pF1KB0 DVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGT 890 900 910 920 930 940 980 990 1000 1010 1020 1030 pF1KB0 CHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGE 950 960 970 980 990 1000 1040 1050 1060 1070 1080 1090 pF1KB0 LCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHC 1010 1020 1030 1040 1050 1060 1100 1110 1120 1130 1140 1150 pF1KB0 TDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGY 1070 1080 1090 1100 1110 1120 1160 1170 1180 1190 1200 1210 pF1KB0 QGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVELY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVELY 1130 1140 1150 1160 1170 1180 1220 1230 1240 1250 1260 1270 pF1KB0 RGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQS 1190 1200 1210 1220 1230 1240 1280 1290 1300 1310 1320 1330 pF1KB0 TLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILP 1250 1260 1270 1280 1290 1300 1340 1350 1360 1370 1380 1390 pF1KB0 GCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAF 1310 1320 1330 1340 1350 1360 1400 1410 1420 1430 1440 1450 pF1KB0 SYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREI 1370 1380 1390 1400 1410 1420 1460 1470 1480 1490 1500 1510 pF1KB0 SCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGSS 1430 1440 1450 1460 1470 1480 1520 pF1KB0 FVDEVEKVVKCGCTRCVS :::::::::::::::::: XP_011 FVDEVEKVVKCGCTRCVS 1490 >>XP_011512212 (OMIM: 603746) PREDICTED: slit homolog 2 (1159 aa) initn: 8040 init1: 8040 opt: 8040 Z-score: 4295.2 bits: 807.1 E(85289): 0 Smith-Waterman score: 8040; 99.6% identity (99.9% similar) in 1130 aa overlap (400-1529:30-1159) 370 380 390 400 410 420 pF1KB0 GLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQ .::::.: ::::.::::::::::::::::: XP_011 MLYPSIAYSFSLLRREFKKISPFLWRKIFFLSLYNNTLQTITKGTFSPLRAIQTMHLAQ 10 20 30 40 50 430 440 450 460 470 480 pF1KB0 NPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGT 60 70 80 90 100 110 490 500 510 520 530 540 pF1KB0 EDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLE 120 130 140 150 160 170 550 560 570 580 590 600 pF1KB0 ATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLK 180 190 200 210 220 230 610 620 630 640 650 660 pF1KB0 TLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCN 240 250 260 270 280 290 670 680 690 700 710 720 pF1KB0 CYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPT 300 310 320 330 340 350 730 740 750 760 770 780 pF1KB0 ECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRI 360 370 380 390 400 410 790 800 810 820 830 840 pF1KB0 STLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 STLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLS 420 430 440 450 460 470 850 860 870 880 890 900 pF1KB0 ALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQG 480 490 500 510 520 530 910 920 930 940 950 960 pF1KB0 PVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHG 540 550 560 570 580 590 970 980 990 1000 1010 1020 pF1KB0 GTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYT 600 610 620 630 640 650 1030 1040 1050 1060 1070 1080 pF1KB0 GELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGA 660 670 680 690 700 710 1090 1100 1110 1120 1130 1140 pF1KB0 HCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLP 720 730 740 750 760 770 1150 1160 1170 1180 1190 1200 pF1KB0 GYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVE 780 790 800 810 820 830 1210 1220 1230 1240 1250 1260 pF1KB0 LYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSK 840 850 860 870 880 890 1270 1280 1290 1300 1310 1320 pF1KB0 QSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGI 900 910 920 930 940 950 1330 1340 1350 1360 1370 1380 pF1KB0 LPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPIN 960 970 980 990 1000 1010 1390 1400 1410 1420 1430 1440 pF1KB0 AFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDR 1020 1030 1040 1050 1060 1070 1450 1460 1470 1480 1490 1500 pF1KB0 EISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDG 1080 1090 1100 1110 1120 1130 1510 1520 pF1KB0 SSFVDEVEKVVKCGCTRCVS :::::::::::::::::::: XP_011 SSFVDEVEKVVKCGCTRCVS 1140 1150 >>NP_001258875 (OMIM: 603745) slit homolog 3 protein iso (1530 aa) initn: 5297 init1: 2055 opt: 7467 Z-score: 3989.7 bits: 751.0 E(85289): 1.7e-215 Smith-Waterman score: 7467; 66.3% identity (87.6% similar) in 1537 aa overlap (3-1527:7-1529) 10 20 30 40 50 pF1KB0 MRGVGWQMLS-LSLGLVLA-ILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIP ::: . . :.:.:.:: .:. :::..:.::...::::::.::.:::.:: NP_001 MAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB0 RNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNH ::.:::::. :::::::: :::::..::::.: .:..:.::::::::::.:::::::.:. NP_001 RNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNK 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB0 LQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRAL ::..::::: .: :: ::::::::::.:::::::: .:.:::::: :.:::::::::::: NP_001 LQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRAL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB0 RDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYT ::::.::::::::.:. :.:::::::.::.:::::.::::::::::::::::: :: .: NP_001 RDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFT 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB0 QCMGPSHLRGHNVAEVQKREFVCSGHQSFMAPSCSV--LHCPAACTCSNNIVDCRGKGLT ::.: :::: :::.:::.:.:: . .: :::.. . ::. ::::::::::::::: NP_001 LCMAPVHLRGFNVADVQKKEYVCPAPHS-EPPSCNANSISCPSPCTCSNNIVDCRGKGLM 250 260 270 280 290 300 310 320 330 340 350 pF1KB0 EIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNS :::.:::: :.:::::::.::.:: :::. ::::.:::.:.::::..::::::::.::.: NP_001 EIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTS 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB0 LVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIA ::::::::::. :.::.:: :::::::::::::::::..::::.:::::::::::::::. NP_001 LVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTIS 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB0 KGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIK :: :.::..:::.:::::::.::::::::::::. ::::::::::.::::::::::.::: NP_001 KGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIK 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB0 SKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIP ::::::: :.:::::..:..:: ::.:::::::::: :::::::: .:: :.: NP_001 SKKFRCS--------GSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLP 480 490 500 510 520 530 540 550 560 570 580 590 pF1KB0 QYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSN .:...::::.:: .::::::::::::.:::::.::::: ...::::.::..:.:..::.: NP_001 EYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGN 540 550 560 570 580 590 600 610 620 630 640 650 pF1KB0 RLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDT .::.:. ..:.:: .::::::::: : ::.::.: :::::::::::::.:::..:::: : NP_001 QLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTT 600 610 620 630 640 650 660 670 680 690 700 710 pF1KB0 LHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTC : ::::.:::.:::::::.:::::.::::.:::.::::::::.::::::::::::::::: NP_001 LVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTC 660 670 680 690 700 710 720 730 740 750 760 770 pF1KB0 DDGNDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKE : ::...::. ::: .:::..::::::::::..::.:.:.:::::::.::..: ::.: NP_001 D-GNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRE 720 730 740 750 760 770 780 790 800 810 820 830 pF1KB0 LSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSL :: .:::::::::: :: :.: .::::..: ::::::::::::: ..:.::.:::.:.: NP_001 LSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTL 780 790 800 810 820 830 840 850 860 870 880 890 pF1KB0 HGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEM :::::: ::::.::::..:::::.:.:::.:::...:::.:::. :::::::::..: : NP_001 HGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPM 840 850 860 870 880 890 900 910 920 930 940 pF1KB0 ADKLLLTTPSKKFTCQ-------GPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTC ::.::::::...: :. ::::.::.:::: :::.::::.:::..:::..:::.: NP_001 ADRLLLTTPTHRFQCKVLWFCCPGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCAC 900 910 920 930 940 950 950 960 970 980 990 1000 pF1KB0 PYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDN ::..::.:: :::..::.:::.:::::::.....::: : : ::::. ::.: :::::: NP_001 PYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDN 960 970 980 990 1000 1010 1010 1020 1030 1040 1050 1060 pF1KB0 DCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCT :::::.:::::::::.:.:::.::::::.: .: :. .:: :::..::: :::.:.:. NP_001 DCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECV 1020 1030 1040 1050 1060 1070 1070 1080 1090 1100 1110 1120 pF1KB0 PGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPC ::: :. :. : ::: .::..::.:.:..::::: ::.:.:: ::: ::::: .:::: NP_001 PGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPC 1080 1090 1100 1110 1120 1130 1130 1140 1150 1160 1170 1180 pF1KB0 DNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNIT :...::::::::: .:: :.: ::. : .::::..:::..:.::... :::::::.::. NP_001 DQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANIS 1140 1150 1160 1170 1180 1190 1190 1200 1210 1220 1230 1240 pF1KB0 LQIATDEDSGILLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVEL ::.:::.:.::::::::.: .:.:::.:.:: ::. : : ...:::::.:::.:: ::: NP_001 LQVATDKDNGILLYKGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVEL 1200 1210 1220 1230 1240 1250 1250 1260 1270 1280 1290 1300 pF1KB0 LALDQSLSLSVDGGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFH ..:.:.:.: :: :.:: . .:.:: .....::::.::.: ......:::. . .:: NP_001 VTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTDRPLGGFH 1260 1270 1280 1290 1300 1310 1310 1320 1330 1340 1350 1360 pF1KB0 GCIRNLYINSELQDFQKVPMQT-GILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMG :::... ::.:::::. .: :. :. :::. : :: :: :. . . .:::. :: : NP_001 GCIHEVRINNELQDFKALPPQSLGVSPGCKSC--TVCKHGLCRSVEKDSVVCECRPGWTG 1320 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 pF1KB0 PLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHG :::::.. :::::..: :: :. .. :: ::: ::.:: :::...: : :.:.::.:: NP_001 PLCDQEARDPCLGHRCHHGKCVATGT-SYMCKCAEGYGGDLCDNKNDSANACSAFKCHHG 1370 1380 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 pF1KB0 KCRLSGLGQPYCECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRG .:..: :.::: :. :..:. :..: : :. .:. ..:.:::.: :..:: .:::: NP_001 QCHISDQGEPYCLCQPGFSGEHCQQENPCLGQVVREVIRRQKGYASCATASKVPIMECRG 1430 1440 1450 1460 1470 1480 1490 1500 1510 1520 pF1KB0 GCAGGQCCGPLRSKRRKYSFECTDGSSFVDEVEKVVKCGCTRCVS :: : ::: : ::::::: :.::::::::.:::. ..::: : NP_001 GC-GPQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCLACS 1490 1500 1510 1520 1530 >>NP_003052 (OMIM: 603742) slit homolog 1 protein precur (1534 aa) initn: 6576 init1: 3063 opt: 7433 Z-score: 3971.6 bits: 747.6 E(85289): 1.8e-214 Smith-Waterman score: 7433; 66.1% identity (87.5% similar) in 1516 aa overlap (15-1527:21-1533) 10 20 30 40 50 pF1KB0 MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIP :. : ... .:::: :.:.:.:::::: .:...:.::: NP_003 MALTPGWGSSAGPVRPELWLLLWAAAWRLGASACPALCTCTGTTVDCHGTGLQAIPKNIP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB0 RNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNH ::::::.::::::::: :.:::::..:::::::::.:...:::::.:.:::::::::::. NP_003 RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB0 LQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRAL :...::::: .. : ::::::: ::::::::::::.:.:::::: :::::::.:::::: NP_003 LHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRAL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB0 RDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYT : :::::::::::: . :.::::::::::::::::.:.:::::::::.:::::: .::.: NP_003 RGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFT 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB0 QCMGPSHLRGHNVAEVQKREFVCSGH-QSFMAPSCSVLH--CPAACTCSNNIVDCRGKGL :: ::. ::: ::::::: :: :::. .. .:.:.. ::: :::::.::::::::: NP_003 QCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGL 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB0 TEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLN : ::.:::::.:::::: : :: :::::::::.::::::::::::.:.:::::::::::: NP_003 TAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLN 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB0 SLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTI ::::::::::.::...: ::..:::::::::::::.: ::::::.::.::::::::.:.. NP_003 SLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSL 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB0 AKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQI :::::. ::::::.:::::::::::.::::::.:.:::::::::::.::::::::::::: NP_003 AKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQI 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB0 KSKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHI ::::::::::::::::::::: .:...: .:..::.:::::...:.::. ::.::::.: NP_003 KSKKFRCSAKEQYFIPGTEDY--QLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERI 490 500 510 520 530 540 550 560 570 580 590 pF1KB0 PQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTS :: ::::::::::...:::::.:::: .:.:::.::::...::.::::::..:.:. ::. NP_003 PQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTA 540 550 560 570 580 590 600 610 620 630 640 650 pF1KB0 NRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFD :.::... ::.::..:.:::::.:::.:. :::: :: .::::::::::::::.::::: NP_003 NQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFD 600 610 620 630 640 650 660 670 680 690 700 710 pF1KB0 TLHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFT ::.:::::::::::::::: ::::: ::::..:::::::::.: ::..::.::::. :: NP_003 TLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFR 660 670 680 690 700 710 720 730 740 750 760 770 pF1KB0 CDDGNDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPK :..:.....: : .:: ::.::::::::::: :..::::::..::::::::::::::: NP_003 CEEGQEEGGCLPRPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPG 720 730 740 750 760 770 780 790 800 810 820 830 pF1KB0 ELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLS .::..:.: :.:::::.::.:::.::.::.:: ::::::: :.:::: .:.::.:::::: NP_003 QLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLS 780 790 800 810 820 830 840 850 860 870 880 890 pF1KB0 LHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGE :::::::.. :: : :...:::::::::::::::...:::.:::. :::::::::::: . NP_003 LHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQD 840 850 860 870 880 890 900 910 920 930 940 950 pF1KB0 MADKLLLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKG : :::::::.::: :::: . . :::. :::.::.:.:::..::.. :::.:: :.:: NP_003 MEGKLLLTTPAKKFECQGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKG 900 910 920 930 940 950 960 970 980 990 1000 1010 pF1KB0 QDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNS .::.: . .: :.::..::::: .:::. : : : :::: .: ::.::: :. : :.. NP_003 RDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGG 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 pF1KB0 TCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGE .::::..:::: :: .: :. ::. .:.:. :::::::...:. :: : .:.: :::.:. NP_003 VCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGD 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 pF1KB0 HCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQ .:. . :::.:..:.:::.: : ::.:.:.: ::::: .::. : . :. :::.. .:: NP_003 NCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPK-SPCEGTECQ 1080 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 pF1KB0 NGAQCIVRINEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATD :::.:. . :.:.::::::. : .::::.::::.....:::. . . :..:::::..: NP_003 NGANCVDQGNRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVSTA 1140 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 pF1KB0 EDSGILLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQS ::.:::::.::.::::::::.:.::.::: ::.:.:::::.::::::.:: :::.:.:: NP_003 EDNGILLYNGDNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQM 1200 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 pF1KB0 LSLSVDGGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNL ..::.:::.: . :..:. ::: ..:::::::: : :..: :::.:::::::: NP_003 VNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNSAAFRLWQILNGTGFHGCIRNL 1260 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 pF1KB0 YINSELQDFQKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRT :::.::::: :. :. :..::::::.: : :: :::.. : :.:. ::.: ::: . NP_003 YINNELQDFTKTQMKPGVVPGCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPA 1320 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 pF1KB0 NDPCLGNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGL . :: :.::::: :.:..:.::::.: .:..:.::.. : .::....: ::.:. :: NP_003 DGPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGT 1380 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 pF1KB0 GQPYCECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC .: :. :..:. :..: :::. .::..: :.::: ::::. .: .::::.: : : NP_003 KGAHCVCDPGFSGELCEQESECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCPGQGC 1440 1450 1460 1470 1480 1490 1500 1510 1520 pF1KB0 CGPLRSKRRKYSFECTDGSSFVDEVEKVVKCGCTRCVS : :: ::::..:::.::.::..:::: .::::. : NP_003 CQGLRLKRRKFTFECSDGTSFAEEVEKPTKCGCALCA 1500 1510 1520 1530 >>NP_003053 (OMIM: 603745) slit homolog 3 protein isofor (1523 aa) initn: 6255 init1: 3023 opt: 6287 Z-score: 3363.0 bits: 635.0 E(85289): 1.4e-180 Smith-Waterman score: 7491; 66.6% identity (88.0% similar) in 1530 aa overlap (3-1527:7-1522) 10 20 30 40 50 pF1KB0 MRGVGWQMLS-LSLGLVLA-ILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIP ::: . . :.:.:.:: .:. :::..:.::...::::::.::.:::.:: NP_003 MAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB0 RNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNH ::.:::::. :::::::: :::::..::::.: .:..:.::::::::::.:::::::.:. NP_003 RNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNK 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB0 LQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRAL ::..::::: .: :: ::::::::::.:::::::: .:.:::::: :.:::::::::::: NP_003 LQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRAL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB0 RDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYT ::::.::::::::.:. :.:::::::.::.:::::.::::::::::::::::: :: .: NP_003 RDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFT 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB0 QCMGPSHLRGHNVAEVQKREFVCSGHQSFMAPSCSV--LHCPAACTCSNNIVDCRGKGLT ::.: :::: :::.:::.:.:: . .: :::.. . ::. ::::::::::::::: NP_003 LCMAPVHLRGFNVADVQKKEYVCPAPHS-EPPSCNANSISCPSPCTCSNNIVDCRGKGLM 250 260 270 280 290 300 310 320 330 340 350 pF1KB0 EIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNS :::.:::: :.:::::::.::.:: :::. ::::.:::.:.::::..::::::::.::.: NP_003 EIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTS 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB0 LVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIA ::::::::::. :.::.:: :::::::::::::::::..::::.:::::::::::::::. NP_003 LVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTIS 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB0 KGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIK :: :.::..:::.:::::::.::::::::::::. ::::::::::.::::::::::.::: NP_003 KGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIK 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB0 SKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIP ::::::: :.:::::..:..:: ::.:::::::::: :::::::: .:: :.: NP_003 SKKFRCS--------GSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLP 480 490 500 510 520 530 540 550 560 570 580 590 pF1KB0 QYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSN .:...::::.:: .::::::::::::.:::::.::::: ...::::.::..:.:..::.: NP_003 EYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGN 540 550 560 570 580 590 600 610 620 630 640 650 pF1KB0 RLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDT .::.:. ..:.:: .::::::::: : ::.::.: :::::::::::::.:::..:::: : NP_003 QLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTT 600 610 620 630 640 650 660 670 680 690 700 710 pF1KB0 LHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTC : ::::.:::.:::::::.:::::.::::.:::.::::::::.::::::::::::::::: NP_003 LVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTC 660 670 680 690 700 710 720 730 740 750 760 770 pF1KB0 DDGNDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKE : ::...::. ::: .:::..::::::::::..::.:.:.:::::::.::..: ::.: NP_003 D-GNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRE 720 730 740 750 760 770 780 790 800 810 820 830 pF1KB0 LSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSL :: .:::::::::: :: :.: .::::..: ::::::::::::: ..:.::.:::.:.: NP_003 LSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTL 780 790 800 810 820 830 840 850 860 870 880 890 pF1KB0 HGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEM :::::: ::::.::::..:::::.:.:::.:::...:::.:::. :::::::::..: : NP_003 HGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPM 840 850 860 870 880 890 900 910 920 930 940 950 pF1KB0 ADKLLLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQ ::.::::::...: :.::::.::.:::: :::.::::.:::..:::..:::.:::..::. NP_003 ADRLLLTTPTHRFQCKGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGK 900 910 920 930 940 950 960 970 980 990 1000 1010 pF1KB0 DCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNST :: :::..::.:::.:::::::.....::: : : ::::. ::.: :::::::::::.: NP_003 DCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNAT 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 pF1KB0 CVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEH ::::::::.:.:::.::::::.: .: :. .:: :::..::: :::.:.:.::: :. NP_003 CVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKL 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 pF1KB0 CDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQN :. : ::: .::..::.:.:..::::: ::.:.:: ::: ::::: .:::::...::: NP_003 CETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQN 1080 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 pF1KB0 GAQCIVRINEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDE :::::: .:: :.: ::. : .::::..:::..:.::... :::::::.::.::.:::. NP_003 GAQCIVVQQEPTCRCPPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANISLQVATDK 1140 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 pF1KB0 DSGILLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSL :.::::::::.: .:.:::.:.:: ::. : : ...:::::.:::.:: :::..:.:.: NP_003 DNGILLYKGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTL 1200 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 pF1KB0 SLSVDGGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLY .: :: :.:: . .:.:: .....::::.::.: ......:::. . .:::::... NP_003 NLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTDRPLGGFHGCIHEVR 1260 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 pF1KB0 INSELQDFQKVPMQT-GILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRT ::.:::::. .: :. :. :::. : :: :: :. . . .:::. :: ::::::.. NP_003 INNELQDFKALPPQSLGVSPGCKSC--TVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEA 1320 1330 1340 1350 1360 1380 1390 1400 1410 1420 1430 pF1KB0 NDPCLGNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGL :::::..: :: :. .. :: ::: ::.:: :::...: : :.:.::.::.:..: NP_003 RDPCLGHRCHHGKCVATGT-SYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQ 1370 1380 1390 1400 1410 1420 1440 1450 1460 1470 1480 1490 pF1KB0 GQPYCECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC :.::: :. :..:. :..: : :. .:. ..:.:::.: :..:: .:::::: : :: NP_003 GEPYCLCQPGFSGEHCQQENPCLGQVVREVIRRQKGYASCATASKVPIMECRGGC-GPQC 1430 1440 1450 1460 1470 1480 1500 1510 1520 pF1KB0 CGPLRSKRRKYSFECTDGSSFVDEVEKVVKCGCTRCVS : : ::::::: :.::::::::.:::. ..::: : NP_003 CQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCLACS 1490 1500 1510 1520 1529 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 16:38:03 2016 done: Mon Nov 7 16:38:05 2016 Total Scan time: 12.660 Total Display time: 0.880 Function used was FASTA [36.3.4 Apr, 2011]