FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3723, 778 aa 1>>>pF1KE3723 778 - 778 aa - 778 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 13.2274+/-0.000619; mu= -17.0851+/- 0.038 mean_var=591.6942+/-132.564, 0's: 0 Z-trim(118.0): 2131 B-trim: 1267 in 1/57 Lambda= 0.052726 statistics sampled from 27948 (30541) to 27948 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.693), E-opt: 0.2 (0.358), width: 16 Scan time: 11.900 The best scores are: opt bits E(85289) XP_011543093 (OMIM: 600526) PREDICTED: serine/thre ( 798) 4996 396.2 2.9e-109 XP_011543092 (OMIM: 600526) PREDICTED: serine/thre ( 799) 4984 395.3 5.5e-109 NP_059672 (OMIM: 600526) serine/threonine-protein ( 745) 4895 388.5 5.7e-107 XP_011543094 (OMIM: 600526) PREDICTED: serine/thre ( 793) 4882 387.5 1.2e-106 NP_001034558 (OMIM: 600526) serine/threonine-prote ( 788) 4212 336.5 2.6e-91 XP_016872799 (OMIM: 600526) PREDICTED: serine/thre ( 763) 4211 336.4 2.7e-91 XP_011543091 (OMIM: 600526) PREDICTED: serine/thre ( 808) 4098 327.9 1.1e-88 XP_011543095 (OMIM: 600526) PREDICTED: serine/thre ( 784) 4085 326.9 2.1e-88 NP_001156769 (OMIM: 600526) serine/threonine-prote ( 709) 3306 267.6 1.3e-70 NP_004945 (OMIM: 600526) serine/threonine-protein ( 724) 3306 267.6 1.4e-70 NP_001156768 (OMIM: 600526) serine/threonine-prote ( 719) 3294 266.7 2.6e-70 XP_011543100 (OMIM: 600526) PREDICTED: serine/thre ( 729) 3192 258.9 5.6e-68 XP_016872800 (OMIM: 600526) PREDICTED: serine/thre ( 738) 3192 258.9 5.6e-68 XP_011543098 (OMIM: 600526) PREDICTED: serine/thre ( 744) 3192 258.9 5.7e-68 XP_011543096 (OMIM: 600526) PREDICTED: serine/thre ( 753) 3192 258.9 5.7e-68 XP_011543099 (OMIM: 600526) PREDICTED: serine/thre ( 739) 3180 258.0 1.1e-67 XP_011543097 (OMIM: 600526) PREDICTED: serine/thre ( 745) 3180 258.0 1.1e-67 NP_001273055 (OMIM: 606511) serine/threonine-prote ( 780) 2889 235.9 5.1e-61 XP_005273191 (OMIM: 606511) PREDICTED: serine/thre ( 781) 2860 233.7 2.3e-60 XP_016856796 (OMIM: 606511) PREDICTED: serine/thre ( 670) 2421 200.2 2.4e-50 NP_061120 (OMIM: 606511) serine/threonine-protein ( 795) 2372 196.6 3.5e-49 NP_001273053 (OMIM: 606511) serine/threonine-prote ( 796) 2327 193.1 3.8e-48 NP_002367 (OMIM: 602678) MAP/microtubule affinity- ( 729) 2277 189.3 5e-47 XP_005267698 (OMIM: 602678) PREDICTED: MAP/microtu ( 738) 2277 189.3 5e-47 NP_001122391 (OMIM: 602678) MAP/microtubule affini ( 744) 2277 189.3 5.1e-47 NP_001122390 (OMIM: 602678) MAP/microtubule affini ( 753) 2277 189.3 5.1e-47 XP_005267700 (OMIM: 602678) PREDICTED: MAP/microtu ( 643) 2259 187.9 1.2e-46 XP_011507863 (OMIM: 606511) PREDICTED: serine/thre ( 788) 2258 187.9 1.4e-46 NP_001273057 (OMIM: 606511) serine/threonine-prote ( 758) 2251 187.3 2e-46 XP_006720209 (OMIM: 602678) PREDICTED: MAP/microtu ( 739) 2203 183.7 2.5e-45 XP_016876781 (OMIM: 602678) PREDICTED: MAP/microtu ( 722) 2146 179.3 5e-44 XP_005267699 (OMIM: 602678) PREDICTED: MAP/microtu ( 737) 2144 179.2 5.6e-44 NP_001122392 (OMIM: 602678) MAP/microtubule affini ( 713) 2140 178.9 6.8e-44 XP_016876780 (OMIM: 602678) PREDICTED: MAP/microtu ( 728) 2140 178.9 6.9e-44 XP_016876782 (OMIM: 602678) PREDICTED: MAP/microtu ( 708) 2072 173.7 2.4e-42 NP_113605 (OMIM: 606495) MAP/microtubule affinity- ( 688) 2024 170.0 3e-41 NP_001186796 (OMIM: 606495) MAP/microtubule affini ( 752) 2017 169.5 4.6e-41 XP_016876787 (OMIM: 602678) PREDICTED: MAP/microtu ( 665) 1960 165.1 8.5e-40 XP_016876785 (OMIM: 602678) PREDICTED: MAP/microtu ( 674) 1960 165.2 8.6e-40 XP_016876784 (OMIM: 602678) PREDICTED: MAP/microtu ( 680) 1960 165.2 8.7e-40 XP_016876783 (OMIM: 602678) PREDICTED: MAP/microtu ( 689) 1960 165.2 8.7e-40 XP_011535071 (OMIM: 602678) PREDICTED: MAP/microtu ( 673) 1959 165.1 9.1e-40 XP_006711389 (OMIM: 606511) PREDICTED: serine/thre ( 708) 1905 161.0 1.6e-38 XP_016856795 (OMIM: 606511) PREDICTED: serine/thre ( 685) 1904 160.9 1.7e-38 XP_016856794 (OMIM: 606511) PREDICTED: serine/thre ( 686) 1859 157.5 1.8e-37 XP_011507864 (OMIM: 606511) PREDICTED: serine/thre ( 686) 1859 157.5 1.8e-37 XP_016876786 (OMIM: 602678) PREDICTED: MAP/microtu ( 673) 1827 155.0 9.5e-37 XP_016876788 (OMIM: 602678) PREDICTED: MAP/microtu ( 664) 1823 154.7 1.2e-36 XP_006723370 (OMIM: 606495) PREDICTED: MAP/microtu ( 685) 1758 149.8 3.7e-35 XP_016876793 (OMIM: 602678) PREDICTED: MAP/microtu ( 598) 1673 143.3 3e-33 >>XP_011543093 (OMIM: 600526) PREDICTED: serine/threonin (798 aa) initn: 4995 init1: 4995 opt: 4996 Z-score: 2082.6 bits: 396.2 E(85289): 2.9e-109 Smith-Waterman score: 4996; 99.2% identity (99.5% similar) in 767 aa overlap (12-778:32-798) 10 20 30 40 pF1KE3 MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSA ..: ::::::::::::::::::::::: XP_011 EVAGSPFPFLQSVACLLTLAHIPAVGNILQHRRRGAGPTLGHLDSKPSSKSNMIRGRNSA 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE3 TSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREV 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE3 RIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVS 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE3 AVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELF 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE3 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLL 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE3 KKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREE 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE3 IQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSA 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE3 NPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLE 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE3 RKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAV 490 500 510 520 530 540 530 540 550 560 570 580 pF1KE3 SAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAP 550 560 570 580 590 600 590 600 610 620 630 640 pF1KE3 DRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKF 610 620 630 640 650 660 650 660 670 680 690 700 pF1KE3 VRRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VRRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMM 670 680 690 700 710 720 710 720 730 740 750 760 pF1KE3 REIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 REIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGT 730 740 750 760 770 780 770 pF1KE3 SMAFKNIASKIANELKL ::::::::::::::::: XP_011 SMAFKNIASKIANELKL 790 >>XP_011543092 (OMIM: 600526) PREDICTED: serine/threonin (799 aa) initn: 2637 init1: 2601 opt: 4984 Z-score: 2077.6 bits: 395.3 E(85289): 5.5e-109 Smith-Waterman score: 4984; 99.1% identity (99.3% similar) in 768 aa overlap (12-778:32-799) 10 20 30 40 pF1KE3 MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSA ..: ::::::::::::::::::::::: XP_011 EVAGSPFPFLQSVACLLTLAHIPAVGNILQHRRRGAGPTLGHLDSKPSSKSNMIRGRNSA 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE3 TSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREV 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE3 RIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVS 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE3 AVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELF 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE3 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLL 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE3 KKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREE 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE3 IQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSA 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE3 NPKQRRFSDQA-GPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGL ::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGL 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE3 ERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAA 490 500 510 520 530 540 530 540 550 560 570 580 pF1KE3 VSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGA 550 560 570 580 590 600 590 600 610 620 630 640 pF1KE3 PDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSK 610 620 630 640 650 660 650 660 670 680 690 700 pF1KE3 FVRRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FVRRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEM 670 680 690 700 710 720 710 720 730 740 750 760 pF1KE3 MREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISG 730 740 750 760 770 780 770 pF1KE3 TSMAFKNIASKIANELKL :::::::::::::::::: XP_011 TSMAFKNIASKIANELKL 790 >>NP_059672 (OMIM: 600526) serine/threonine-protein kina (745 aa) initn: 4895 init1: 4895 opt: 4895 Z-score: 2041.4 bits: 388.5 E(85289): 5.7e-107 Smith-Waterman score: 4895; 100.0% identity (100.0% similar) in 745 aa overlap (34-778:1-745) 10 20 30 40 50 60 pF1KE3 ARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGN :::::::::::::::::::::::::::::: NP_059 MIRGRNSATSADEQPHIGNYRLLKTIGKGN 10 20 30 70 80 90 100 110 120 pF1KE3 FAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 FAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEK 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE3 TLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 TLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLL 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE3 DADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 DADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTL 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE3 VSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 VSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRW 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE3 MNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 MNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGY 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE3 KSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAGPAIPTSNSYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 KSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAGPAIPTSNSYS 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE3 KKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 KKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSR 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE3 NSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 NSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKAS 460 470 480 490 500 510 550 560 570 580 590 600 pF1KE3 GLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 GLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQ 520 530 540 550 560 570 610 620 630 640 650 660 pF1KE3 VRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLNEPESKDRVETLRPHVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 VRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLNEPESKDRVETLRPHVV 580 590 600 610 620 630 670 680 690 700 710 720 pF1KE3 GSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 GSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYML 640 650 660 670 680 690 730 740 750 760 770 pF1KE3 LCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 LCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 700 710 720 730 740 >>XP_011543094 (OMIM: 600526) PREDICTED: serine/threonin (793 aa) initn: 3434 init1: 2601 opt: 4882 Z-score: 2035.7 bits: 387.5 E(85289): 1.2e-106 Smith-Waterman score: 4882; 97.5% identity (98.2% similar) in 768 aa overlap (12-778:32-793) 10 20 30 40 pF1KE3 MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSA ..: ::::::::::::::::::::::: XP_011 EVAGSPFPFLQSVACLLTLAHIPAVGNILQHRRRGAGPTLGHLDSKPSSKSNMIRGRNSA 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE3 TSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREV 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE3 RIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVS 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE3 AVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELF 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE3 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLL 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE3 KKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREE 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE3 IQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSA 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE3 NPKQRRFSDQA-GPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGL ::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGL 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE3 ERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAA 490 500 510 520 530 540 530 540 550 560 570 580 pF1KE3 VSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGA 550 560 570 580 590 600 590 600 610 620 630 640 pF1KE3 PDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSK 610 620 630 640 650 660 650 660 670 680 690 700 pF1KE3 FVRRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEM ::::::. .. :::::::::::::::::::::::::::::::::::::::::: XP_011 FVRRNLSFRFAR------RPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEM 670 680 690 700 710 710 720 730 740 750 760 pF1KE3 MREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISG 720 730 740 750 760 770 770 pF1KE3 TSMAFKNIASKIANELKL :::::::::::::::::: XP_011 TSMAFKNIASKIANELKL 780 790 >>NP_001034558 (OMIM: 600526) serine/threonine-protein k (788 aa) initn: 4264 init1: 2716 opt: 4212 Z-score: 1760.3 bits: 336.5 E(85289): 2.6e-91 Smith-Waterman score: 5070; 98.7% identity (98.7% similar) in 788 aa overlap (1-778:1-788) 10 20 30 40 50 60 pF1KE3 MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 310 320 330 340 350 360 370 380 390 400 410 pF1KE3 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQA-GPAIPTS :::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::: NP_001 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE3 NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE3 NRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHP 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE3 NKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG 550 560 570 580 590 600 600 610 620 630 640 650 pF1KE3 QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNL---------NEPE ::::::::::::::::::::::::::::::::::::::::::::::: :::: NP_001 QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPE 610 620 630 640 650 660 660 670 680 690 700 710 pF1KE3 SKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDA 670 680 690 700 710 720 720 730 740 750 760 770 pF1KE3 NSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS 730 740 750 760 770 780 pF1KE3 KIANELKL :::::::: NP_001 KIANELKL >>XP_016872799 (OMIM: 600526) PREDICTED: serine/threonin (763 aa) initn: 4211 init1: 4211 opt: 4211 Z-score: 1760.1 bits: 336.4 E(85289): 2.7e-91 Smith-Waterman score: 4975; 98.1% identity (98.1% similar) in 778 aa overlap (1-778:1-763) 10 20 30 40 50 60 pF1KE3 MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAGPAIPTSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAGPAIPTSN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 SYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 RSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPN 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 KASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 LRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLNEPESKDRVETLRP :::::::::::::::::::::::::::::::::::::::::::: : XP_016 LRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRR---------------P 610 620 630 640 670 680 690 700 710 720 pF1KE3 HVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEK 650 660 670 680 690 700 730 740 750 760 770 pF1KE3 YMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 710 720 730 740 750 760 >>XP_011543091 (OMIM: 600526) PREDICTED: serine/threonin (808 aa) initn: 4149 init1: 2601 opt: 4098 Z-score: 1713.3 bits: 327.9 E(85289): 1.1e-88 Smith-Waterman score: 4956; 97.9% identity (98.2% similar) in 777 aa overlap (12-778:32-808) 10 20 30 40 pF1KE3 MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSA ..: ::::::::::::::::::::::: XP_011 EVAGSPFPFLQSVACLLTLAHIPAVGNILQHRRRGAGPTLGHLDSKPSSKSNMIRGRNSA 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE3 TSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREV 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE3 RIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVS 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE3 AVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELF 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE3 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLL 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE3 KKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREE 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE3 IQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSA 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE3 NPKQRRFSDQA-GPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGL ::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGL 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE3 ERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAA 490 500 510 520 530 540 530 540 550 560 570 580 pF1KE3 VSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGA 550 560 570 580 590 600 590 600 610 620 630 640 pF1KE3 PDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSK 610 620 630 640 650 660 650 660 670 680 690 pF1KE3 FVRRNL---------NEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKT :::::: ::::::::::::::::::::::::::::::::::::::::::::: XP_011 FVRRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKT 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE3 TSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLN 730 740 750 760 770 780 760 770 pF1KE3 GVRFKRISGTSMAFKNIASKIANELKL ::::::::::::::::::::::::::: XP_011 GVRFKRISGTSMAFKNIASKIANELKL 790 800 >>XP_011543095 (OMIM: 600526) PREDICTED: serine/threonin (784 aa) initn: 3434 init1: 2601 opt: 4085 Z-score: 1708.1 bits: 326.9 E(85289): 2.1e-88 Smith-Waterman score: 4849; 97.1% identity (97.4% similar) in 768 aa overlap (12-778:32-784) 10 20 30 40 pF1KE3 MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSA ..: ::::::::::::::::::::::: XP_011 EVAGSPFPFLQSVACLLTLAHIPAVGNILQHRRRGAGPTLGHLDSKPSSKSNMIRGRNSA 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE3 TSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREV 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE3 RIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVS 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE3 AVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELF 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE3 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLL 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE3 KKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREE 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE3 IQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSA 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE3 NPKQRRFSDQA-GPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGL ::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGL 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE3 ERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAA 490 500 510 520 530 540 530 540 550 560 570 580 pF1KE3 VSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGA 550 560 570 580 590 600 590 600 610 620 630 640 pF1KE3 PDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSK 610 620 630 640 650 660 650 660 670 680 690 700 pF1KE3 FVRRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEM ::: :::::::::::::::::::::::::::::::::::::::::: XP_011 FVR---------------RPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEM 670 680 690 700 710 720 730 740 750 760 pF1KE3 MREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISG 710 720 730 740 750 760 770 pF1KE3 TSMAFKNIASKIANELKL :::::::::::::::::: XP_011 TSMAFKNIASKIANELKL 770 780 >>NP_001156769 (OMIM: 600526) serine/threonine-protein k (709 aa) initn: 4079 init1: 3282 opt: 3306 Z-score: 1388.4 bits: 267.6 E(85289): 1.3e-70 Smith-Waterman score: 4504; 91.1% identity (91.1% similar) in 778 aa overlap (1-778:1-709) 10 20 30 40 50 60 pF1KE3 MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAGPAIPTSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAGPAIPTSN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 SYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 RSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPN :::::::::::::::::::::::: NP_001 RSRNSPLLERASLGQASIQNGKDS------------------------------------ 490 500 550 560 570 580 590 600 pF1KE3 KASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQ :::::::::::::::::::::::::::::::::::::::::: NP_001 ------------------TAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQ 510 520 530 540 610 620 630 640 650 660 pF1KE3 LRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLNEPESKDRVETLRP :::::::::::::::::::::::::::::::::::::::::::: : NP_001 LRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRR---------------P 550 560 570 580 590 670 680 690 700 710 720 pF1KE3 HVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEK 600 610 620 630 640 650 730 740 750 760 770 pF1KE3 YMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 660 670 680 690 700 >>NP_004945 (OMIM: 600526) serine/threonine-protein kina (724 aa) initn: 3282 init1: 3282 opt: 3306 Z-score: 1388.3 bits: 267.6 E(85289): 1.4e-70 Smith-Waterman score: 4639; 93.1% identity (93.1% similar) in 778 aa overlap (1-778:1-724) 10 20 30 40 50 60 pF1KE3 MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAGPAIPTSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAGPAIPTSN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 SYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 RSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPN :::::::::::::::::::::::: NP_004 RSRNSPLLERASLGQASIQNGKDS------------------------------------ 490 500 550 560 570 580 590 600 pF1KE3 KASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQ :::::::::::::::::::::::::::::::::::::::::: NP_004 ------------------TAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQ 510 520 530 540 610 620 630 640 650 660 pF1KE3 LRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLNEPESKDRVETLRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLNEPESKDRVETLRP 550 560 570 580 590 600 670 680 690 700 710 720 pF1KE3 HVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 HVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEK 610 620 630 640 650 660 730 740 750 760 770 pF1KE3 YMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 YMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 670 680 690 700 710 720 778 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 16:27:10 2016 done: Mon Nov 7 16:27:11 2016 Total Scan time: 11.900 Total Display time: 0.210 Function used was FASTA [36.3.4 Apr, 2011]