FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3454, 1328 aa 1>>>pF1KE3454 1328 - 1328 aa - 1328 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.7821+/-0.0015; mu= 5.6485+/- 0.087 mean_var=239.8199+/-54.361, 0's: 0 Z-trim(105.3): 725 B-trim: 467 in 1/48 Lambda= 0.082819 statistics sampled from 7526 (8344) to 7526 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.601), E-opt: 0.2 (0.256), width: 16 Scan time: 5.520 The best scores are: opt bits E(32554) CCDS2176.2 MAP3K19 gene_id:80122|Hs108|chr2 (1328) 8850 1072.8 0 CCDS63020.1 MAP3K19 gene_id:80122|Hs108|chr2 (1215) 7604 923.8 0 CCDS33293.1 MAP3K19 gene_id:80122|Hs108|chr2 ( 510) 2055 260.5 8.5e-69 CCDS63021.1 MAP3K19 gene_id:80122|Hs108|chr2 ( 460) 1731 221.7 3.5e-57 CCDS63022.1 MAP3K19 gene_id:80122|Hs108|chr2 ( 462) 1503 194.5 5.7e-49 CCDS82186.1 MAP3K3 gene_id:4215|Hs108|chr17 ( 622) 807 111.5 7.6e-24 CCDS32702.1 MAP3K3 gene_id:4215|Hs108|chr17 ( 626) 807 111.5 7.6e-24 CCDS32701.1 MAP3K3 gene_id:4215|Hs108|chr17 ( 657) 807 111.5 7.9e-24 CCDS46404.1 MAP3K2 gene_id:10746|Hs108|chr2 ( 619) 797 110.3 1.7e-23 CCDS35212.2 MAP3K15 gene_id:389840|Hs108|chrX (1313) 684 97.0 3.5e-19 CCDS5179.1 MAP3K5 gene_id:4217|Hs108|chr6 (1374) 663 94.6 2e-18 CCDS72738.1 MAP3K6 gene_id:9064|Hs108|chr1 (1280) 646 92.5 7.9e-18 CCDS299.1 MAP3K6 gene_id:9064|Hs108|chr1 (1288) 646 92.5 8e-18 CCDS43318.1 MAP3K1 gene_id:4214|Hs108|chr5 (1512) 622 89.7 6.5e-17 CCDS34566.1 MAP3K4 gene_id:4216|Hs108|chr6 (1558) 613 88.6 1.4e-16 CCDS75544.1 MAP3K4 gene_id:4216|Hs108|chr6 (1604) 613 88.6 1.4e-16 CCDS34565.1 MAP3K4 gene_id:4216|Hs108|chr6 (1608) 613 88.6 1.4e-16 CCDS58707.1 MAP4K3 gene_id:8491|Hs108|chr2 ( 873) 569 83.1 3.5e-15 CCDS1803.1 MAP4K3 gene_id:8491|Hs108|chr2 ( 894) 569 83.2 3.6e-15 CCDS42564.1 MAP4K1 gene_id:11184|Hs108|chr19 ( 821) 530 78.5 8.5e-14 CCDS59385.1 MAP4K1 gene_id:11184|Hs108|chr19 ( 833) 530 78.5 8.6e-14 CCDS81582.1 MAP4K2 gene_id:5871|Hs108|chr11 ( 812) 528 78.2 1e-13 CCDS8082.1 MAP4K2 gene_id:5871|Hs108|chr11 ( 820) 528 78.2 1e-13 CCDS14631.1 STK26 gene_id:51765|Hs108|chrX ( 416) 522 77.2 1e-13 CCDS32001.1 STK24 gene_id:8428|Hs108|chr13 ( 431) 518 76.8 1.4e-13 CCDS9488.1 STK24 gene_id:8428|Hs108|chr13 ( 443) 518 76.8 1.5e-13 CCDS2549.1 STK25 gene_id:10494|Hs108|chr2 ( 426) 517 76.7 1.6e-13 CCDS6854.1 NEK6 gene_id:10783|Hs108|chr9 ( 313) 505 75.1 3.4e-13 CCDS55338.1 NEK6 gene_id:10783|Hs108|chr9 ( 331) 505 75.1 3.5e-13 CCDS55339.1 NEK6 gene_id:10783|Hs108|chr9 ( 338) 505 75.1 3.5e-13 CCDS48015.1 NEK6 gene_id:10783|Hs108|chr9 ( 347) 505 75.1 3.6e-13 CCDS54673.1 TNIK gene_id:23043|Hs108|chr3 (1268) 515 76.8 4e-13 CCDS54674.1 TNIK gene_id:23043|Hs108|chr3 (1276) 515 76.8 4.1e-13 CCDS54677.1 TNIK gene_id:23043|Hs108|chr3 (1297) 515 76.9 4.1e-13 CCDS54678.1 TNIK gene_id:23043|Hs108|chr3 (1305) 515 76.9 4.1e-13 CCDS54675.1 TNIK gene_id:23043|Hs108|chr3 (1323) 515 76.9 4.2e-13 CCDS54676.1 TNIK gene_id:23043|Hs108|chr3 (1331) 515 76.9 4.2e-13 CCDS54679.1 TNIK gene_id:23043|Hs108|chr3 (1352) 515 76.9 4.2e-13 CCDS46956.1 TNIK gene_id:23043|Hs108|chr3 (1360) 515 76.9 4.3e-13 CCDS2863.1 NEK4 gene_id:6787|Hs108|chr3 ( 841) 505 75.5 6.9e-13 CCDS82487.1 MAP4K4 gene_id:9448|Hs108|chr2 (1165) 507 75.9 7.4e-13 CCDS56130.1 MAP4K4 gene_id:9448|Hs108|chr2 (1239) 507 75.9 7.7e-13 CCDS74546.1 MAP4K4 gene_id:9448|Hs108|chr2 (1273) 507 75.9 7.9e-13 CCDS1394.1 NEK7 gene_id:140609|Hs108|chr1 ( 302) 493 73.6 8.8e-13 CCDS76334.1 SLK gene_id:9748|Hs108|chr10 (1204) 505 75.6 8.9e-13 CCDS7553.1 SLK gene_id:9748|Hs108|chr10 (1235) 505 75.6 9.1e-13 CCDS7148.1 MYO3A gene_id:53904|Hs108|chr10 (1616) 505 75.7 1.1e-12 CCDS45589.1 MINK1 gene_id:50488|Hs108|chr17 (1303) 498 74.8 1.7e-12 CCDS45590.1 MINK1 gene_id:50488|Hs108|chr17 (1312) 498 74.8 1.7e-12 CCDS45588.1 MINK1 gene_id:50488|Hs108|chr17 (1332) 498 74.8 1.7e-12 >>CCDS2176.2 MAP3K19 gene_id:80122|Hs108|chr2 (1328 aa) initn: 8850 init1: 8850 opt: 8850 Z-score: 5731.0 bits: 1072.8 E(32554): 0 Smith-Waterman score: 8850; 100.0% identity (100.0% similar) in 1328 aa overlap (1-1328:1-1328) 10 20 30 40 50 60 pF1KE3 MSSMPKPERHAESLLDICHDTNSSPTDLMTVTKNQNIILQSISRSEEFDQDGDCSHSTLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 MSSMPKPERHAESLLDICHDTNSSPTDLMTVTKNQNIILQSISRSEEFDQDGDCSHSTLV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 NEEEDPSGGRQDWQPRTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 NEEEDPSGGRQDWQPRTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 SHPNEIETVELRKKKLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTREDAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 SHPNEIETVELRKKKLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTREDAP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 HFLKEQQRKSEEFSTSHMKYSGRSIKFLLPPLSLLPTRSGVLTIPQNHKFPKEKERNIPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 HFLKEQQRKSEEFSTSHMKYSGRSIKFLLPPLSLLPTRSGVLTIPQNHKFPKEKERNIPS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 LTSFVPKLSVSVRQSDELSPSNEPPGALVKSLMDPTLRSSDGFIWSRNMCSFPKTNHHRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 LTSFVPKLSVSVRQSDELSPSNEPPGALVKSLMDPTLRSSDGFIWSRNMCSFPKTNHHRQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 CLEKEENWKSKEIEECNKIEITHFEKGQSLVSFENLKEGNIPAVREEDIDCHGSKTRKPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 CLEKEENWKSKEIEECNKIEITHFEKGQSLVSFENLKEGNIPAVREEDIDCHGSKTRKPE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 EENSQYLSSRKNESSVAKNYEQDPEIVCTIPSKFQETQHSEITPSQDEEMRNNKAASKRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 EENSQYLSSRKNESSVAKNYEQDPEIVCTIPSKFQETQHSEITPSQDEEMRNNKAASKRV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 SLHKNEAMEPNNILEECTVLKSLSSVVFDDPIDKLPEGCSSMETNIKISIAERAKPEMSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 SLHKNEAMEPNNILEECTVLKSLSSVVFDDPIDKLPEGCSSMETNIKISIAERAKPEMSR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 MVPLIHITFPVDGSPKEPVIAKPSLQTRKGTIHNNHSVNIPVHQENDKHKMNSHRSKLDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 MVPLIHITFPVDGSPKEPVIAKPSLQTRKGTIHNNHSVNIPVHQENDKHKMNSHRSKLDS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 KTKTSKKTPQNFVISTEGPIKPTMHKTSIKTQIFPALGLVDPRPWQLPRFQKKMPQIAKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 KTKTSKKTPQNFVISTEGPIKPTMHKTSIKTQIFPALGLVDPRPWQLPRFQKKMPQIAKK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 QSTHRTQKPKKQSFPCICKNPGTQKSCVPLSVQPTEPRLNYLDLKYSDMFKEINSTANGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 QSTHRTQKPKKQSFPCICKNPGTQKSCVPLSVQPTEPRLNYLDLKYSDMFKEINSTANGP 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 GIYEMFGTPVYCHVRETERDENTYYREICSAPSGRRITNKCRSSHSERKSNIRTRLSQKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 GIYEMFGTPVYCHVRETERDENTYYREICSAPSGRRITNKCRSSHSERKSNIRTRLSQKK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 THMKCPKTSFGIKQEHKVLISKEKSSKAVHSNLHDIENGDGISEPDWQIKSSGNEFLSSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 THMKCPKTSFGIKQEHKVLISKEKSSKAVHSNLHDIENGDGISEPDWQIKSSGNEFLSSK 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 DEIHPMNLAQTPEQSMKQNEFPPVSDLSIVEEVSMEESTGDRDISNNQILTTSLRDLQEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 DEIHPMNLAQTPEQSMKQNEFPPVSDLSIVEEVSMEESTGDRDISNNQILTTSLRDLQEL 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE3 EELHHQIPFIPSEDSWAVPSEKNSNKYVQQEKQNTASLSKVNASRILTNDLEFDSVSDHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 EELHHQIPFIPSEDSWAVPSEKNSNKYVQQEKQNTASLSKVNASRILTNDLEFDSVSDHS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE3 KTLTNFSFQAKQESASSQTYQYWVHYLDHDSLANKSITYQMFGKTLSGTNSISQEIMDSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 KTLTNFSFQAKQESASSQTYQYWVHYLDHDSLANKSITYQMFGKTLSGTNSISQEIMDSV 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE3 NNEELTDELLGCLAAELLALDEKDNNSCQKMANETDPENLNLVLRWRGSTPKEMGRETTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 NNEELTDELLGCLAAELLALDEKDNNSCQKMANETDPENLNLVLRWRGSTPKEMGRETTK 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE3 VKIQRHSSGLRIYDREEKFLISNEKKIFSENSLKSEEPILWTKGEILGKGAYGTVYCGLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 VKIQRHSSGLRIYDREEKFLISNEKKIFSENSLKSEEPILWTKGEILGKGAYGTVYCGLT 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE3 SQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 SQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFM 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE3 EFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 EFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGII 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE3 KLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 KLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEM 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE3 ATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 ATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLK 1270 1280 1290 1300 1310 1320 pF1KE3 HSFLERSH :::::::: CCDS21 HSFLERSH >>CCDS63020.1 MAP3K19 gene_id:80122|Hs108|chr2 (1215 aa) initn: 7604 init1: 7604 opt: 7604 Z-score: 4926.9 bits: 923.8 E(32554): 0 Smith-Waterman score: 7881; 91.5% identity (91.5% similar) in 1328 aa overlap (1-1328:1-1215) 10 20 30 40 50 60 pF1KE3 MSSMPKPERHAESLLDICHDTNSSPTDLMTVTKNQNIILQSISRSEEFDQDGDCSHSTLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 MSSMPKPERHAESLLDICHDTNSSPTDLMTVTKNQNIILQSISRSEEFDQDGDCSHSTLV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 NEEEDPSGGRQDWQPRTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAV :::::::::::::::::: CCDS63 NEEEDPSGGRQDWQPRTE------------------------------------------ 70 130 140 150 160 170 180 pF1KE3 SHPNEIETVELRKKKLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTREDAP CCDS63 ------------------------------------------------------------ 190 200 210 220 230 240 pF1KE3 HFLKEQQRKSEEFSTSHMKYSGRSIKFLLPPLSLLPTRSGVLTIPQNHKFPKEKERNIPS ::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 -----------EFSTSHMKYSGRSIKFLLPPLSLLPTRSGVLTIPQNHKFPKEKERNIPS 80 90 100 110 120 250 260 270 280 290 300 pF1KE3 LTSFVPKLSVSVRQSDELSPSNEPPGALVKSLMDPTLRSSDGFIWSRNMCSFPKTNHHRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 LTSFVPKLSVSVRQSDELSPSNEPPGALVKSLMDPTLRSSDGFIWSRNMCSFPKTNHHRQ 130 140 150 160 170 180 310 320 330 340 350 360 pF1KE3 CLEKEENWKSKEIEECNKIEITHFEKGQSLVSFENLKEGNIPAVREEDIDCHGSKTRKPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 CLEKEENWKSKEIEECNKIEITHFEKGQSLVSFENLKEGNIPAVREEDIDCHGSKTRKPE 190 200 210 220 230 240 370 380 390 400 410 420 pF1KE3 EENSQYLSSRKNESSVAKNYEQDPEIVCTIPSKFQETQHSEITPSQDEEMRNNKAASKRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 EENSQYLSSRKNESSVAKNYEQDPEIVCTIPSKFQETQHSEITPSQDEEMRNNKAASKRV 250 260 270 280 290 300 430 440 450 460 470 480 pF1KE3 SLHKNEAMEPNNILEECTVLKSLSSVVFDDPIDKLPEGCSSMETNIKISIAERAKPEMSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 SLHKNEAMEPNNILEECTVLKSLSSVVFDDPIDKLPEGCSSMETNIKISIAERAKPEMSR 310 320 330 340 350 360 490 500 510 520 530 540 pF1KE3 MVPLIHITFPVDGSPKEPVIAKPSLQTRKGTIHNNHSVNIPVHQENDKHKMNSHRSKLDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 MVPLIHITFPVDGSPKEPVIAKPSLQTRKGTIHNNHSVNIPVHQENDKHKMNSHRSKLDS 370 380 390 400 410 420 550 560 570 580 590 600 pF1KE3 KTKTSKKTPQNFVISTEGPIKPTMHKTSIKTQIFPALGLVDPRPWQLPRFQKKMPQIAKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 KTKTSKKTPQNFVISTEGPIKPTMHKTSIKTQIFPALGLVDPRPWQLPRFQKKMPQIAKK 430 440 450 460 470 480 610 620 630 640 650 660 pF1KE3 QSTHRTQKPKKQSFPCICKNPGTQKSCVPLSVQPTEPRLNYLDLKYSDMFKEINSTANGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 QSTHRTQKPKKQSFPCICKNPGTQKSCVPLSVQPTEPRLNYLDLKYSDMFKEINSTANGP 490 500 510 520 530 540 670 680 690 700 710 720 pF1KE3 GIYEMFGTPVYCHVRETERDENTYYREICSAPSGRRITNKCRSSHSERKSNIRTRLSQKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 GIYEMFGTPVYCHVRETERDENTYYREICSAPSGRRITNKCRSSHSERKSNIRTRLSQKK 550 560 570 580 590 600 730 740 750 760 770 780 pF1KE3 THMKCPKTSFGIKQEHKVLISKEKSSKAVHSNLHDIENGDGISEPDWQIKSSGNEFLSSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 THMKCPKTSFGIKQEHKVLISKEKSSKAVHSNLHDIENGDGISEPDWQIKSSGNEFLSSK 610 620 630 640 650 660 790 800 810 820 830 840 pF1KE3 DEIHPMNLAQTPEQSMKQNEFPPVSDLSIVEEVSMEESTGDRDISNNQILTTSLRDLQEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 DEIHPMNLAQTPEQSMKQNEFPPVSDLSIVEEVSMEESTGDRDISNNQILTTSLRDLQEL 670 680 690 700 710 720 850 860 870 880 890 900 pF1KE3 EELHHQIPFIPSEDSWAVPSEKNSNKYVQQEKQNTASLSKVNASRILTNDLEFDSVSDHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 EELHHQIPFIPSEDSWAVPSEKNSNKYVQQEKQNTASLSKVNASRILTNDLEFDSVSDHS 730 740 750 760 770 780 910 920 930 940 950 960 pF1KE3 KTLTNFSFQAKQESASSQTYQYWVHYLDHDSLANKSITYQMFGKTLSGTNSISQEIMDSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 KTLTNFSFQAKQESASSQTYQYWVHYLDHDSLANKSITYQMFGKTLSGTNSISQEIMDSV 790 800 810 820 830 840 970 980 990 1000 1010 1020 pF1KE3 NNEELTDELLGCLAAELLALDEKDNNSCQKMANETDPENLNLVLRWRGSTPKEMGRETTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 NNEELTDELLGCLAAELLALDEKDNNSCQKMANETDPENLNLVLRWRGSTPKEMGRETTK 850 860 870 880 890 900 1030 1040 1050 1060 1070 1080 pF1KE3 VKIQRHSSGLRIYDREEKFLISNEKKIFSENSLKSEEPILWTKGEILGKGAYGTVYCGLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 VKIQRHSSGLRIYDREEKFLISNEKKIFSENSLKSEEPILWTKGEILGKGAYGTVYCGLT 910 920 930 940 950 960 1090 1100 1110 1120 1130 1140 pF1KE3 SQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 SQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFM 970 980 990 1000 1010 1020 1150 1160 1170 1180 1190 1200 pF1KE3 EFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 EFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGII 1030 1040 1050 1060 1070 1080 1210 1220 1230 1240 1250 1260 pF1KE3 KLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 KLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEM 1090 1100 1110 1120 1130 1140 1270 1280 1290 1300 1310 1320 pF1KE3 ATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 ATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLK 1150 1160 1170 1180 1190 1200 pF1KE3 HSFLERSH :::::::: CCDS63 HSFLERSH 1210 >>CCDS33293.1 MAP3K19 gene_id:80122|Hs108|chr2 (510 aa) initn: 2053 init1: 2053 opt: 2055 Z-score: 1348.6 bits: 260.5 E(32554): 8.5e-69 Smith-Waterman score: 2062; 77.8% identity (84.7% similar) in 424 aa overlap (911-1328:102-510) 890 900 910 920 930 pF1KE3 VNASRILTNDLEFDSVSDHSKTLTNFSFQAKQESASSQTYQYWV--HYLDHDSLANKSIT :... ... : :. : ..: :. : CCDS33 DWQPRTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAVSH---PNEIET 80 90 100 110 120 940 950 960 970 980 990 pF1KE3 YQMFGKTLSGTNSISQEIMDSVNNEELTDELLGCLAAELLALDEKDNNSCQKMANETDPE .. : :. . :. :: . :: . . :: . . : .... : :. CCDS33 VELRKKKLTMRPLVLQK-------EESSRELCNVNLGFLLPRSCLELNISKSVTREDAPH 130 140 150 160 170 180 1000 1010 1020 1030 1040 1050 pF1KE3 NLNLVLR----WRGSTPKEMGRETTKVKIQRHSSGLRIYDREEKFLISNEKKIFSENSLK :. : . : : :: .:.:::::::::::::::::::::::::::::: CCDS33 FLKEQQRKSEEFSTSHMKYSGR-----SIKRHSSGLRIYDREEKFLISNEKKIFSENSLK 190 200 210 220 230 1060 1070 1080 1090 1100 1110 pF1KE3 SEEPILWTKGEILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 SEEPILWTKGEILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDL 240 250 260 270 280 290 1120 1130 1140 1150 1160 1170 pF1KE3 LKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 LKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGV 300 310 320 330 340 350 1180 1190 1200 1210 1220 1230 pF1KE3 AYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 AYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWM 360 370 380 390 400 410 1240 1250 1260 1270 1280 1290 pF1KE3 APEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 APEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFS 420 430 440 450 460 470 1300 1310 1320 pF1KE3 ENAADFVRMCLTRDQHERPSALQLLKHSFLERSH :::::::::::::::::::::::::::::::::: CCDS33 ENAADFVRMCLTRDQHERPSALQLLKHSFLERSH 480 490 500 510 >-- initn: 687 init1: 687 opt: 687 Z-score: 465.2 bits: 97.0 E(32554): 1.4e-19 Smith-Waterman score: 687; 100.0% identity (100.0% similar) in 101 aa overlap (1-101:1-101) 10 20 30 40 50 60 pF1KE3 MSSMPKPERHAESLLDICHDTNSSPTDLMTVTKNQNIILQSISRSEEFDQDGDCSHSTLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 MSSMPKPERHAESLLDICHDTNSSPTDLMTVTKNQNIILQSISRSEEFDQDGDCSHSTLV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 NEEEDPSGGRQDWQPRTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAV ::::::::::::::::::::::::::::::::::::::::: CCDS33 NEEEDPSGGRQDWQPRTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 SHPNEIETVELRKKKLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTREDAP CCDS33 SHPNEIETVELRKKKLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTREDAP 130 140 150 160 170 180 >>CCDS63021.1 MAP3K19 gene_id:80122|Hs108|chr2 (460 aa) initn: 3072 init1: 1723 opt: 1731 Z-score: 1140.0 bits: 221.7 E(32554): 3.5e-57 Smith-Waterman score: 1731; 92.5% identity (96.1% similar) in 281 aa overlap (1048-1328:183-460) 1020 1030 1040 1050 1060 1070 pF1KE3 TTKVKIQRHSSGLRIYDREEKFLISNEKKIFSENSLKSEEPILWTKGEILGKGAYGTVYC ..:.. :::: .. ... .: ::: CCDS63 CNVNLGFLLPRSCLELNISKSVTREDAPHFLKEQQRKSEE---FSTSHMKYSGRSIKVYC 160 170 180 190 200 1080 1090 1100 1110 1120 1130 pF1KE3 GLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 GLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVS 210 220 230 240 250 260 1140 1150 1160 1170 1180 1190 pF1KE3 IFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 IFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPT 270 280 290 300 310 320 1200 1210 1220 1230 1240 1250 pF1KE3 GIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 GIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTV 330 340 350 360 370 380 1260 1270 1280 1290 1300 1310 pF1KE3 FEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 FEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQ 390 400 410 420 430 440 1320 pF1KE3 LLKHSFLERSH ::::::::::: CCDS63 LLKHSFLERSH 450 460 >-- initn: 1212 init1: 1212 opt: 1212 Z-score: 804.8 bits: 159.7 E(32554): 1.6e-38 Smith-Waterman score: 1212; 100.0% identity (100.0% similar) in 182 aa overlap (1-182:1-182) 10 20 30 40 50 60 pF1KE3 MSSMPKPERHAESLLDICHDTNSSPTDLMTVTKNQNIILQSISRSEEFDQDGDCSHSTLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 MSSMPKPERHAESLLDICHDTNSSPTDLMTVTKNQNIILQSISRSEEFDQDGDCSHSTLV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 NEEEDPSGGRQDWQPRTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 NEEEDPSGGRQDWQPRTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 SHPNEIETVELRKKKLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTREDAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 SHPNEIETVELRKKKLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTREDAP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 HFLKEQQRKSEEFSTSHMKYSGRSIKFLLPPLSLLPTRSGVLTIPQNHKFPKEKERNIPS :: CCDS63 HFLKEQQRKSEEFSTSHMKYSGRSIKVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKL 190 200 210 220 230 240 >>CCDS63022.1 MAP3K19 gene_id:80122|Hs108|chr2 (462 aa) initn: 2848 init1: 1499 opt: 1503 Z-score: 992.7 bits: 194.5 E(32554): 5.7e-49 Smith-Waterman score: 1656; 66.5% identity (73.3% similar) in 424 aa overlap (911-1328:102-462) 890 900 910 920 930 pF1KE3 VNASRILTNDLEFDSVSDHSKTLTNFSFQAKQESASSQTYQYWV--HYLDHDSLANKSIT :... ... : :. : ..: :. : CCDS63 DWQPRTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAVSH---PNEIET 80 90 100 110 120 940 950 960 970 980 990 pF1KE3 YQMFGKTLSGTNSISQEIMDSVNNEELTDELLGCLAAELLALDEKDNNSCQKMANETDPE .. : :. . :. :: . :: . . :: . . : .... : :. CCDS63 VELRKKKLTMRPLVLQK-------EESSRELCNVNLGFLLPRSCLELNISKSVTREDAPH 130 140 150 160 170 180 1000 1010 1020 1030 1040 1050 pF1KE3 NLNLVLR----WRGSTPKEMGRETTKVKIQRHSSGLRIYDREEKFLISNEKKIFSENSLK :. : . : : :: .:.:::::::::::::::::::::::::::::: CCDS63 FLKEQQRKSEEFSTSHMKYSGR-----SIKRHSSGLRIYDREEKFLISNEKKIFSENSLK 190 200 210 220 230 1060 1070 1080 1090 1100 1110 pF1KE3 SEEPILWTKGEILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDL ::::::::: ::: CCDS63 SEEPILWTK------------------------------------------------VDL 240 1120 1130 1140 1150 1160 1170 pF1KE3 LKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 LKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGV 250 260 270 280 290 300 1180 1190 1200 1210 1220 1230 pF1KE3 AYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 AYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWM 310 320 330 340 350 360 1240 1250 1260 1270 1280 1290 pF1KE3 APEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 APEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFS 370 380 390 400 410 420 1300 1310 1320 pF1KE3 ENAADFVRMCLTRDQHERPSALQLLKHSFLERSH :::::::::::::::::::::::::::::::::: CCDS63 ENAADFVRMCLTRDQHERPSALQLLKHSFLERSH 430 440 450 460 >-- initn: 687 init1: 687 opt: 687 Z-score: 465.8 bits: 97.0 E(32554): 1.3e-19 Smith-Waterman score: 687; 100.0% identity (100.0% similar) in 101 aa overlap (1-101:1-101) 10 20 30 40 50 60 pF1KE3 MSSMPKPERHAESLLDICHDTNSSPTDLMTVTKNQNIILQSISRSEEFDQDGDCSHSTLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 MSSMPKPERHAESLLDICHDTNSSPTDLMTVTKNQNIILQSISRSEEFDQDGDCSHSTLV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 NEEEDPSGGRQDWQPRTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAV ::::::::::::::::::::::::::::::::::::::::: CCDS63 NEEEDPSGGRQDWQPRTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 SHPNEIETVELRKKKLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTREDAP CCDS63 SHPNEIETVELRKKKLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTREDAP 130 140 150 160 170 180 >>CCDS82186.1 MAP3K3 gene_id:4215|Hs108|chr17 (622 aa) initn: 763 init1: 295 opt: 807 Z-score: 541.6 bits: 111.5 E(32554): 7.6e-24 Smith-Waterman score: 807; 45.0% identity (70.1% similar) in 298 aa overlap (1030-1323:331-617) 1000 1010 1020 1030 1040 1050 pF1KE3 LNLVLRWRGSTPKEMGRETTKVKIQRHSSGLRIYDREEKFLISNEKKIFSENSLKSEEPI :: : :. . .. :... ... :: CCDS82 LFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSENALSVQ-ERNVPTKSP---SAPI 310 320 330 340 350 1060 1070 1080 1090 1100 1110 pF1KE3 LWTKGEILGKGAYGTVY-CGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKAL : .:..::.::.: :: : .. :. .: ::: .: .. . :: :. :..::: : CCDS82 NWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSP-ETSKEVSALECEIQLLKNL 360 370 380 390 400 410 1120 1130 1140 1150 1160 1170 pF1KE3 KHVNIVAYLGTCLQ---ENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVA .: :: : : ::. :.:..::::..::::... .. .: : : : :::.:::.:.. CCDS82 QHERIVQYYG-CLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMS 420 430 440 450 460 470 1180 1190 1200 1210 1220 1230 pF1KE3 YLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMA ::: : .::::::: :.. .: .:: ::: ..:: ..:: ..:. ::::::. CCDS82 YLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTG---MRSVTGTPYWMS 480 490 500 510 520 530 1240 1250 1260 1270 1280 1290 pF1KE3 PEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSE ::::. :::::.:.::.:::: :: : ::: : .. :::.: : : . : ::.:.:: CCDS82 PEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKI-ATQPTNPQLPSHISE 540 550 560 570 580 590 1300 1310 1320 pF1KE3 NAADFVRMCLTRDQHERPSALQLLKHSFLERSH .. ::.: .. . ..:::: .:: : : CCDS82 HGRDFLRRIFV-EARQRPSAEELLTHHFAQLMY 600 610 620 >>CCDS32702.1 MAP3K3 gene_id:4215|Hs108|chr17 (626 aa) initn: 763 init1: 295 opt: 807 Z-score: 541.6 bits: 111.5 E(32554): 7.6e-24 Smith-Waterman score: 807; 45.0% identity (70.1% similar) in 298 aa overlap (1030-1323:335-621) 1000 1010 1020 1030 1040 1050 pF1KE3 LNLVLRWRGSTPKEMGRETTKVKIQRHSSGLRIYDREEKFLISNEKKIFSENSLKSEEPI :: : :. . .. :... ... :: CCDS32 LFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSENALSVQ-ERNVPTKSP---SAPI 310 320 330 340 350 360 1060 1070 1080 1090 1100 1110 pF1KE3 LWTKGEILGKGAYGTVY-CGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKAL : .:..::.::.: :: : .. :. .: ::: .: .. . :: :. :..::: : CCDS32 NWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSP-ETSKEVSALECEIQLLKNL 370 380 390 400 410 1120 1130 1140 1150 1160 1170 pF1KE3 KHVNIVAYLGTCLQ---ENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVA .: :: : : ::. :.:..::::..::::... .. .: : : : :::.:::.:.. CCDS32 QHERIVQYYG-CLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMS 420 430 440 450 460 470 1180 1190 1200 1210 1220 1230 pF1KE3 YLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMA ::: : .::::::: :.. .: .:: ::: ..:: ..:: ..:. ::::::. CCDS32 YLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTG---MRSVTGTPYWMS 480 490 500 510 520 530 1240 1250 1260 1270 1280 1290 pF1KE3 PEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSE ::::. :::::.:.::.:::: :: : ::: : .. :::.: : : . : ::.:.:: CCDS32 PEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKI-ATQPTNPQLPSHISE 540 550 560 570 580 590 1300 1310 1320 pF1KE3 NAADFVRMCLTRDQHERPSALQLLKHSFLERSH .. ::.: .. . ..:::: .:: : : CCDS32 HGRDFLRRIFV-EARQRPSAEELLTHHFAQLMY 600 610 620 >>CCDS32701.1 MAP3K3 gene_id:4215|Hs108|chr17 (657 aa) initn: 763 init1: 295 opt: 807 Z-score: 541.3 bits: 111.5 E(32554): 7.9e-24 Smith-Waterman score: 807; 45.0% identity (70.1% similar) in 298 aa overlap (1030-1323:366-652) 1000 1010 1020 1030 1040 1050 pF1KE3 LNLVLRWRGSTPKEMGRETTKVKIQRHSSGLRIYDREEKFLISNEKKIFSENSLKSEEPI :: : :. . .. :... ... :: CCDS32 LFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSENALSVQ-ERNVPTKSP---SAPI 340 350 360 370 380 390 1060 1070 1080 1090 1100 1110 pF1KE3 LWTKGEILGKGAYGTVY-CGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKAL : .:..::.::.: :: : .. :. .: ::: .: .. . :: :. :..::: : CCDS32 NWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSP-ETSKEVSALECEIQLLKNL 400 410 420 430 440 450 1120 1130 1140 1150 1160 1170 pF1KE3 KHVNIVAYLGTCLQ---ENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVA .: :: : : ::. :.:..::::..::::... .. .: : : : :::.:::.:.. CCDS32 QHERIVQYYG-CLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMS 460 470 480 490 500 1180 1190 1200 1210 1220 1230 pF1KE3 YLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMA ::: : .::::::: :.. .: .:: ::: ..:: ..:: ..:. ::::::. CCDS32 YLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTG---MRSVTGTPYWMS 510 520 530 540 550 560 1240 1250 1260 1270 1280 1290 pF1KE3 PEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSE ::::. :::::.:.::.:::: :: : ::: : .. :::.: : : . : ::.:.:: CCDS32 PEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKI-ATQPTNPQLPSHISE 570 580 590 600 610 620 1300 1310 1320 pF1KE3 NAADFVRMCLTRDQHERPSALQLLKHSFLERSH .. ::.: .. . ..:::: .:: : : CCDS32 HGRDFLRRIFV-EARQRPSAEELLTHHFAQLMY 630 640 650 >>CCDS46404.1 MAP3K2 gene_id:10746|Hs108|chr2 (619 aa) initn: 666 init1: 314 opt: 797 Z-score: 535.2 bits: 110.3 E(32554): 1.7e-23 Smith-Waterman score: 797; 48.6% identity (68.9% similar) in 280 aa overlap (1049-1324:344-616) 1020 1030 1040 1050 1060 1070 pF1KE3 TKVKIQRHSSGLRIYDREEKFLISNEKKIFSENSLKSEEPILWTKGEILGKGAYGTVY-C : : . . : : :..::.::.: :: : CCDS46 SSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLC 320 330 340 350 360 370 1080 1090 1100 1110 1120 1130 pF1KE3 GLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCL---QEN .. :. .::::: .: .. . :: :. :..::: : : :: : : :: ::. CCDS46 YDVDTGRELAVKQVQFDPDSP-ETSKEVNALECEIQLLKNLLHERIVQYYG-CLRDPQEK 380 390 400 410 420 430 1140 1150 1160 1170 1180 1190 pF1KE3 TVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVML :.:::::..:::::.. .. .: : : : :::.:::.:: ::: : .::::::: :.. CCDS46 TLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILR 440 450 460 470 480 490 1200 1210 1220 1230 1240 1250 pF1KE3 MPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIG :: .:: ::: ..:: :.:: .::. ::::::.::::. :::::.::::.. CCDS46 DSTGNVKLGDFGASKRLQTICLSGTG---MKSVTGTPYWMSPEVISGEGYGRKADIWSVA 500 510 520 530 540 1260 1270 1280 1290 1300 1310 pF1KE3 CTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPS ::: :: : ::: : .. :::.: : : . : :: : :. . ::.. .. . . ::: CCDS46 CTVVEMLTEKPPWAEFEAMAAIFKI-ATQPTNPKLPPHVSDYTRDFLKRIFV-EAKLRPS 550 560 570 580 590 600 1320 pF1KE3 ALQLLKHSFLERSH : .::.: :. CCDS46 ADELLRHMFVHYH 610 >>CCDS35212.2 MAP3K15 gene_id:389840|Hs108|chrX (1313 aa) initn: 659 init1: 225 opt: 684 Z-score: 457.9 bits: 97.0 E(32554): 3.5e-19 Smith-Waterman score: 684; 42.7% identity (71.2% similar) in 267 aa overlap (1066-1326:657-910) 1040 1050 1060 1070 1080 1090 pF1KE3 EEKFLISNEKKIFSENSLKSEEPILWTKGEILGKGAYGTVYCGLTSQGQL-IAVKQVALD .::::.:: :: : ..:. ::.:.. CCDS35 TAGSTVELEGETDGDTLEYEYDHDANGERVVLGKGTYGIVYAGRDLSNQVRIAIKEIPER 630 640 650 660 670 680 1100 1110 1120 1130 1140 1150 pF1KE3 TSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSII-N : . . :.::. : : ::: ::: :::. ... ..:::: :::::.:... . CCDS35 DS------RYSQPLHEEIALHKYLKHRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRS 690 700 710 720 730 740 1160 1170 1180 1190 1200 1210 pF1KE3 RFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMP-TGIIKLIDFGCARRLA ..::. : .. ::::::.:. ::::: .:::::::.::.. .:..:. ::: ..:: CCDS35 KWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRL- 750 760 770 780 790 1220 1230 1240 1250 1260 1270 pF1KE3 WAGLNGTHSDMLKSMHGTPYWMAPEVINES--GYGRKSDIWSIGCTVFEMATGKPPLASM ::.: ... :: .::::.:... ::: .::::.:::..::::.:::. . CCDS35 -AGVNPC----TETFTGTLQYMAPEIIDQGPRGYGAPADIWSLGCTIIEMATSKPPFHEL 800 810 820 830 840 850 1280 1290 1300 1310 1320 pF1KE3 DR-MAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLERSH . .:::: .: . . : .:. .: .: :. :. : :.: .. .::...::.. CCDS35 GEPQAAMFKVGMFK-IHPEIPEALSAEARAFILSCFEPDPHKRATTAELLREGFLRQVNK 860 870 880 890 900 910 CCDS35 GKKNRIAFKPSEGPRGVVLALPTQGEPMATSSSEHGSVSPDSDAQPDALFERTRAPRHHL 920 930 940 950 960 970 1328 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 16:22:30 2016 done: Mon Nov 7 16:22:31 2016 Total Scan time: 5.520 Total Display time: 0.260 Function used was FASTA [36.3.4 Apr, 2011]