FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1282, 794 aa 1>>>pF1KE1282 794 - 794 aa - 794 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.3039+/-0.000409; mu= -7.8248+/- 0.026 mean_var=560.5673+/-117.891, 0's: 0 Z-trim(125.6): 12 B-trim: 1672 in 1/60 Lambda= 0.054170 statistics sampled from 49600 (49625) to 49600 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.819), E-opt: 0.2 (0.582), width: 16 Scan time: 12.990 The best scores are: opt bits E(85289) NP_078772 (OMIM: 611720) interferon regulatory fac ( 796) 5436 439.9 2e-122 NP_001070865 (OMIM: 615332) interferon regulatory ( 571) 750 73.5 2.8e-12 NP_892017 (OMIM: 615332) interferon regulatory fac ( 587) 750 73.5 2.9e-12 NP_056464 (OMIM: 615331) interferon regulatory fac ( 584) 616 63.1 4.1e-09 >>NP_078772 (OMIM: 611720) interferon regulatory factor (796 aa) initn: 4833 init1: 4833 opt: 5436 Z-score: 2318.8 bits: 439.9 E(85289): 2e-122 Smith-Waterman score: 5436; 99.7% identity (99.7% similar) in 796 aa overlap (1-794:1-796) 10 20 30 40 50 60 pF1KE1 MSAAQVSSSRRQSCYLCDLPRMPWAMIWDFSEPVCRGCVNYEGADRIEFVIETARQLKRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 MSAAQVSSSRRQSCYLCDLPRMPWAMIWDFSEPVCRGCVNYEGADRIEFVIETARQLKRA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 HGCFQDGRSPGPPPPVGVKTVALSAKEAAAAAAAAAAAAAAAQQQQQQQQQQQQQQQQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 HGCFQDGRSPGPPPPVGVKTVALSAKEAAAAAAAAAAAAAAAQQQQQQQQQQQQQQQQQQ 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 QQQQQ--LNHVDGSSKPAVLAAPSGLERYGLSAAAAAAAAAAAAVEQRSRFEYPPPPVSL ::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 QQQQQQQLNHVDGSSKPAVLAAPSGLERYGLSAAAAAAAAAAAAVEQRSRFEYPPPPVSL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE1 GSSSHTARLPNGLGGPNGFPKPTPEEGPPELNRQSPNSSSAAASVASRRGTHGGLVTGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 GSSSHTARLPNGLGGPNGFPKPTPEEGPPELNRQSPNSSSAAASVASRRGTHGGLVTGLP 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE1 NPGGGGGPQLTVPPNLLPQTLLNGPASAAVLPPPPPHALGSRGPPTPAPPGAPGGPACLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 NPGGGGGPQLTVPPNLLPQTLLNGPASAAVLPPPPPHALGSRGPPTPAPPGAPGGPACLG 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE1 GTPGVSATSSSASSSTSSSVAEVGVGAGGKRPGSVSSTDQERELKEKQRNAEALAELSES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 GTPGVSATSSSASSSTSSSVAEVGVGAGGKRPGSVSSTDQERELKEKQRNAEALAELSES 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE1 LRNRAEEWASKPKMVRDTLLTLAGCTPYEVRFKKDHSLLGRVFAFDAVSKPGMDYELKLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 LRNRAEEWASKPKMVRDTLLTLAGCTPYEVRFKKDHSLLGRVFAFDAVSKPGMDYELKLF 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE1 IEYPTGSGNVYSSASGVAKQMYQDCMKDFGRGLSSGFKYLEYEKKHGSGDWRLLGDLLPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 IEYPTGSGNVYSSASGVAKQMYQDCMKDFGRGLSSGFKYLEYEKKHGSGDWRLLGDLLPE 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE1 AVRFFKEGVPGADMLPQPYLDASCPMLPTALVSLSRAPSAPPGTGALPPAAPSGRGAAAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 AVRFFKEGVPGADMLPQPYLDASCPMLPTALVSLSRAPSAPPGTGALPPAAPSGRGAAAS 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE1 LRKRKASPEPPDSAEGALKLGEEQQRQQWMANQSEALKLTMSAGGFAAPGHAAGGPPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 LRKRKASPEPPDSAEGALKLGEEQQRQQWMANQSEALKLTMSAGGFAAPGHAAGGPPPPP 550 560 570 580 590 600 600 610 620 630 640 650 pF1KE1 PPLGPHSNRTTPPESAPQNGPSPMAALMSVADTLGTAHSPKDGSSVHSTTASARRNSSSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 PPLGPHSNRTTPPESAPQNGPSPMAALMSVADTLGTAHSPKDGSSVHSTTASARRNSSSP 610 620 630 640 650 660 660 670 680 690 700 710 pF1KE1 VSPASVPGQRRLASRNGDLNLQVAPPPPSAHPGMDQVHPQNIPDSPMANSGPLCCTICHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 VSPASVPGQRRLASRNGDLNLQVAPPPPSAHPGMDQVHPQNIPDSPMANSGPLCCTICHE 670 680 690 700 710 720 720 730 740 750 760 770 pF1KE1 RLEDTHFVQCPSVPSHKFCFPCSRESIKAQGATGEVYCPSGEKCPLVGSNVPWAFMQGEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 RLEDTHFVQCPSVPSHKFCFPCSRESIKAQGATGEVYCPSGEKCPLVGSNVPWAFMQGEI 730 740 750 760 770 780 780 790 pF1KE1 ATILAGDVKVKKERDP :::::::::::::::: NP_078 ATILAGDVKVKKERDP 790 >>NP_001070865 (OMIM: 615332) interferon regulatory fact (571 aa) initn: 1575 init1: 673 opt: 750 Z-score: 341.3 bits: 73.5 E(85289): 2.8e-12 Smith-Waterman score: 1476; 41.4% identity (55.6% similar) in 795 aa overlap (2-793:4-570) 10 20 30 40 50 pF1KE1 MSAAQVSSSRRQSCYLCDLPRMPWAMIWDFSEPVCRGCVNYEGADRIEFVIETARQLK ..: ...::::::::::::::::::::::.:::::::::::::::.::::::::::: NP_001 MAAAVAVAAASRRQSCYLCDLPRMPWAMIWDFTEPVCRGCVNYEGADRVEFVIETARQLK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 RAHGCFQDGRSPGPPPPVGVKTVALSAKEAAAAAAAAAAAAAAAQQQQQQQQQQQQQQQQ :::::: .:::: : .:::.::: .:.. ::: NP_001 RAHGCFPEGRSP---P-------------GAAASAAAKPPPLSAKDILLQQQ-------- 70 80 90 120 130 140 150 160 170 pF1KE1 QQQQQQQLNHVDGSSKPAVLAAPSGLERYGLSAAAAAAAAAAAAVEQRSRFEYPPPPVSL :::.: . : ::..:::: : :::: . : : : .:: NP_001 -----QQLGHGGPEAAP---RAPQALERYPL------AAAAERPPRLGSDFGSSRPAASL 100 110 120 130 140 180 190 200 210 220 230 pF1KE1 GSSSHTARLP-NGLGGPNGFPKPTPEEGPPELNRQSPNSSSAAASVASRRGTHGGLVTGL .. : ::. :::: : : :::::::::: ::: :. NP_001 AQPPTPQPPPVNGILVPNGFSK---LEEPPELNRQSPNP---------RRG-HA------ 150 160 170 180 240 250 260 270 280 290 pF1KE1 PNPGGGGGPQLTVPPNLLPQTLLNGPASAAVLPPPPPHALGSRGPPTPAPPGAPGGPACL :::.:.: :.:: :. : : ::: : NP_001 ------------VPPTLVP--LMNGSAT------PLPTALG------------------L 190 200 300 310 320 330 340 350 pF1KE1 GGTPGVSATSSSASSSTS-SSVAEVGVGAGGKRPGSVSSTDQERELKEKQRNAEALAELS :: ..: .. :.....: .:. . .:: :::.::::. ....::.: : NP_001 GGRAAASLAAVSGTAAASLGSAQPTDLGAH-KRPASVSSS---AAVEHEQREAAA----- 210 220 230 240 250 360 370 380 390 400 410 pF1KE1 ESLRNRAEEWASKPKMVRDTLLTLAGCTPYEVRFKKDHSLLGRVFAFDAVSKPGMDYELK .: : : NP_001 -------KEKQPPPPAHR------------------------------------------ 260 420 430 440 450 460 470 pF1KE1 LFIEYPTGSGNVYSSASGVAKQMYQDCMKDFGRGLSSGFKYLEYEKKHGSGDWRLLGDLL : .. :.:.:.:. .. : : : : : :: NP_001 -------GPADSLSTAAGAAE------LSAEGAGKSRG---------SGEQDWVN----R 270 280 290 300 480 490 500 510 520 530 pF1KE1 PEAVRFFKEGVPGADMLPQPYLDASCPMLPTALVSLSRAPSAPPGTGALPPAAPSGRGAA :..:: .:..: . . : . . :. ..: NP_001 PKTVR-------------------------DTLLALHQHGHSGPFESKFKKE-PALTAVA 310 320 330 540 550 560 570 580 590 pF1KE1 ASLRKRKASPEPPDSAEGALKLGEEQQRQQWMANQSEALKLTMS-AGGFAAPGHAAGGPP . :::: :::: .. : :.. : : :.....:.::. :. ...:.. NP_001 RTARKRKPSPEP-EGEVGPPKINGEA--QPWLSTSTEGLKIPMTPTSSFVS--------- 340 350 360 370 380 600 610 620 630 640 650 pF1KE1 PPPPPLGPHSNRTTPPESAPQNGPSPMAALMSVADTLGTAHSPKDGSSVHSTTASARRNS :::: .::::::::::.: ::: ::::::. :::. : .:. ::...::::: :::: NP_001 PPPPTASPHSNRTTPPEAA-QNGQSPMAALILVADNAGGSHASKDANQVHSTT---RRNS 390 400 410 420 430 660 670 680 690 700 710 pF1KE1 SSPVSPASVPGQRRLASRNGDLNLQVAPPPPSAHPGMDQVHPQNIPDSPMANSGPLCCTI .:: ::.:. .::::. : .:. . :.. ::: ..::: .:.:.:::::. NP_001 NSPPSPSSM-NQRRLGPR------EVGGQGAGNTGGLEPVHPASLPDSSLATSAPLCCTL 440 450 460 470 480 490 720 730 740 750 760 770 pF1KE1 CHERLEDTHFVQCPSVPSHKFCFPCSRESIKAQGATGEVYCPSGEKCPLVGSNVPWAFMQ :::::::::::::::::::::::::::.::: :::.:::::::::::::::::::::::: NP_001 CHERLEDTHFVQCPSVPSHKFCFPCSRQSIKQQGASGEVYCPSGEKCPLVGSNVPWAFMQ 500 510 520 530 540 550 780 790 pF1KE1 GEIATILAGDVKVKKERDP :::::::::::::::::: NP_001 GEIATILAGDVKVKKERDS 560 570 >>NP_892017 (OMIM: 615332) interferon regulatory factor (587 aa) initn: 1581 init1: 673 opt: 750 Z-score: 341.2 bits: 73.5 E(85289): 2.9e-12 Smith-Waterman score: 1500; 41.7% identity (56.2% similar) in 797 aa overlap (2-793:4-586) 10 20 30 40 50 pF1KE1 MSAAQVSSSRRQSCYLCDLPRMPWAMIWDFSEPVCRGCVNYEGADRIEFVIETARQLK ..: ...::::::::::::::::::::::.:::::::::::::::.::::::::::: NP_892 MAAAVAVAAASRRQSCYLCDLPRMPWAMIWDFTEPVCRGCVNYEGADRVEFVIETARQLK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 RAHGCFQDGRSPGPPPPVGVKTVALSAKEAAAAAAAAAAAAAAAQQQQQQQQQQQQQQQQ :::::: .:::: : .:::.::: .:.. ::: NP_892 RAHGCFPEGRSP---P-------------GAAASAAAKPPPLSAKDILLQQQ-------- 70 80 90 120 130 140 150 160 170 pF1KE1 QQQQQQQLNHVDGSSKPAVLAAPSGLERYGLSAAAAAAAAAAAAVEQRSRFEYPPPPVSL :::.: . : ::..:::: : :::: . : : : .:: NP_892 -----QQLGHGGPEAAP---RAPQALERYPL------AAAAERPPRLGSDFGSSRPAASL 100 110 120 130 140 180 190 200 210 220 230 pF1KE1 GSSSHTARLP-NGLGGPNGFPKPTPEEGPPELNRQSPNSSSAAASVASRRGTHGGLVTGL .. : ::. :::: : : :::::::::: ::: :. NP_892 AQPPTPQPPPVNGILVPNGFSK---LEEPPELNRQSPNP---------RRG-HA------ 150 160 170 180 240 250 260 270 280 290 pF1KE1 PNPGGGGGPQLTVPPNLLPQTLLNGPASAAVLPPPPPHALGSRGPPTPAPPGAPGGPACL :::.:.: :.:: :. : : ::: : NP_892 ------------VPPTLVP--LMNGSAT------PLPTALG------------------L 190 200 300 310 320 330 340 350 pF1KE1 GGTPGVSATSSSASSSTS-SSVAEVGVGAGGKRPGSVSSTDQERELKEKQRNAEALAELS :: ..: .. :.....: .:. . .:: :::.::::. ....::.: : NP_892 GGRAAASLAAVSGTAAASLGSAQPTDLGAH-KRPASVSSS---AAVEHEQREAAA----- 210 220 230 240 250 360 370 380 390 400 410 pF1KE1 ESLRNRAEEWASKPKMVRDTLLTLAGCTPYEVRFKKDHSLLGRVFAFDAVSKPGMDYELK .: : : NP_892 -------KEKQPPPPAHR------------------------------------------ 260 420 430 440 450 460 470 pF1KE1 LFIEYPTGSGNVYSSASGVAKQMYQDCMKDFGRGLSSGFKYLEYEKKHGSGDWRLLGDLL : .. :.:.:.:. .. : : : : : :: NP_892 -------GPADSLSTAAGAAE------LSAEGAGKSRG---------SGEQDWVNR---- 270 280 290 300 480 490 500 510 520 530 pF1KE1 PEAVRFFKEGVPGADMLPQPYLDASCPMLPTALVSLSRAPSAPPGT--GALPPAAPSGRG :..:: .: : :. .... :. : : .: .... NP_892 PKTVR--------DTLLALHQHGHSGPFES----KFKKEPALTAGRLLGFEANGANGSKA 310 320 330 340 540 550 560 570 580 590 pF1KE1 AAASLRKRKASPEPPDSAEGALKLGEEQQRQQWMANQSEALKLTMS-AGGFAAPGHAAGG .: . :::: :::: .. : :.. : : :.....:.::. :. ...:.. NP_892 VARTARKRKPSPEP-EGEVGPPKINGEAQ--PWLSTSTEGLKIPMTPTSSFVS------- 350 360 370 380 390 600 610 620 630 640 650 pF1KE1 PPPPPPPLGPHSNRTTPPESAPQNGPSPMAALMSVADTLGTAHSPKDGSSVHSTTASARR :::: .::::::::::.: ::: ::::::. :::. : .:. ::...::::: :: NP_892 --PPPPTASPHSNRTTPPEAA-QNGQSPMAALILVADNAGGSHASKDANQVHSTT---RR 400 410 420 430 440 450 660 670 680 690 700 710 pF1KE1 NSSSPVSPASVPGQRRLASRNGDLNLQVAPPPPSAHPGMDQVHPQNIPDSPMANSGPLCC ::.:: ::.:. .::::. : .:. . :.. ::: ..::: .:.:.:::: NP_892 NSNSPPSPSSM-NQRRLGPR------EVGGQGAGNTGGLEPVHPASLPDSSLATSAPLCC 460 470 480 490 500 720 730 740 750 760 770 pF1KE1 TICHERLEDTHFVQCPSVPSHKFCFPCSRESIKAQGATGEVYCPSGEKCPLVGSNVPWAF :.:::::::::::::::::::::::::::.::: :::.:::::::::::::::::::::: NP_892 TLCHERLEDTHFVQCPSVPSHKFCFPCSRQSIKQQGASGEVYCPSGEKCPLVGSNVPWAF 510 520 530 540 550 560 780 790 pF1KE1 MQGEIATILAGDVKVKKERDP :::::::::::::::::::: NP_892 MQGEIATILAGDVKVKKERDS 570 580 >>NP_056464 (OMIM: 615331) interferon regulatory factor (584 aa) initn: 1595 init1: 577 opt: 616 Z-score: 284.6 bits: 63.1 E(85289): 4.1e-09 Smith-Waterman score: 1679; 43.4% identity (60.2% similar) in 797 aa overlap (4-794:2-584) 10 20 30 40 50 60 pF1KE1 MSAAQVSSSRRQSCYLCDLPRMPWAMIWDFSEPVCRGCVNYEGADRIEFVIETARQLKRA :.:..:::: :::::::.:::::.::::: :::::::.:::::::..:..::::::. NP_056 MASVQASRRQWCYLCDLPKMPWAMVWDFSEAVCRGCVNFEGADRIELLIDAARQLKRS 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 HGCFQDGRSPGPPPPVGVKTVALSAKEAAAAAAAAAAAAAAAQQQQQQQQQQQQQQQQQQ : . .::::::: : :. :::::: : : : : . NP_056 H-VLPEGRSPGPP--------------ALKHPATKDLAAAAAQGPQLPPPQAQPQPS--- 60 70 80 90 100 130 140 150 160 170 pF1KE1 QQQQQLNHVDGSSKPAVLAAPSGLERYGLSAAAAAAAAAAAAVEQRSRFEYPPPPV--SL :.. .. :: .:: ..... :. : : . .: NP_056 ----------GTG-----GGVSGQDRYDRATSSG-------------RLPLPSPALEYTL 110 120 130 180 190 200 210 220 230 pF1KE1 GSSSHTARLPNGLGGPNGFPKPTPEEGPPELNRQSPNSSSAAASVASRRGTHGGLVTGLP :: :: :::: :: :.. ..::. :.. NP_056 GS-----RLANGLGR---------EE---------------AVAEGARRALLGSM----- 140 150 240 250 260 270 280 290 pF1KE1 NPGGGGGPQLTVPPNLLPQTLLNGPASAAVLPPPPPHALGSRGPPTPAPPGAPGGPACLG :: .::.:: .::: .::::: : NP_056 -PG-------LMPPGLL---------AAAV------SGLGSRG---------------LT 160 170 180 300 310 320 330 340 350 pF1KE1 GTPGVSATSSSASSSTSSSVAEVGVGAGGKRPGSVSSTDQERELKEKQRNAEALAELSES .::.: . :: . ..: :.: ..::::. ::::.:. NP_056 LAPGLSPA----------------------RP--LFGSDFEKE--KQQRNADCLAELNEA 190 200 210 360 370 380 390 400 410 pF1KE1 LRNRAEEWASKPKMVRDTLLTLAGCTPYEVRFKKDHSLLGRVFAFDAVSKP-GMDYELKL .:.::::: ..:: ::. ::.:..:.:..:::::::.:.::::::::...: :...:::: NP_056 MRGRAEEWHGRPKAVREQLLALSACAPFNVRFKKDHGLVGRVFAFDATARPPGYEFELKL 220 230 240 250 260 270 420 430 440 450 460 470 pF1KE1 FIEYPTGSGNVYSSASGVAKQMYQDCMKDFGRGL-SSGFKYLEYEKKHGSGDWRLLGDLL : ::: ::::::... .::.::..: ... :..: ::::::::::..::::.:: ::.:: NP_056 FTEYPCGSGNVYAGVLAVARQMFHDALREPGKALASSGFKYLEYERRHGSGEWRQLGELL 280 290 300 310 320 330 480 490 500 510 520 530 pF1KE1 PEAVRFFKEGVPGADMLPQPYLDASCPMLPTALVSLSRAPSAPPGTGALPPAAPSGRGAA ..:: :.: .: :. ::: : : ::.: : :: ::: :. : NP_056 TDGVRSFREPAP-AEALPQQY--------PEP------APAALCGP---PPRAPS-RNLA 340 350 360 370 540 550 560 570 580 590 pF1KE1 ASLRKRKASPEPPDSAEGALKLGEEQQRQQWMANQSEALKLTMSAGGFAAPGHAAGGPPP . :.::::::: : : . ::::...:.: :: NP_056 PTPRRRKASPEPEGEAAGKMTT-EEQQQRHWVA-----------------PG-------- 380 390 400 600 610 620 630 640 650 pF1KE1 PPPPLGPHSNRTTPPESAPQNGPSPMAALMSVADTLGTAHSPKDGSSVHSTTASARRNSS ::.: .: : . :::.::: .::..:: ::::: .. . .: ... NP_056 -----GPYSAET-P------GVPSPIAALKNVAEALG--HSPKDPGG---GGGPVRAGGA 410 420 430 440 450 660 670 680 690 700 710 pF1KE1 SPV--SPASVPGQRRLASRNGDLNLQVAPPPPSAHPGMDQVHPQNIPDSPMANSGPLCCT ::. : :. : :.::..:::. : :.: : . : . . . ..::::: NP_056 SPAASSTAQPPTQHRLVARNGE-----AEVSPTA--GAEAVSGGG-SGTGATPGAPLCCT 460 470 480 490 500 720 730 740 750 760 770 pF1KE1 ICHERLEDTHFVQCPSVPSHKFCFPCSRESIKAQGATGEVYCPSGEKCPLVGSNVPWAFM .:.:::::::::::::::.:::::::::: ::::: .::::::::.:::::::.:::::: NP_056 LCRERLEDTHFVQCPSVPGHKFCFPCSREFIKAQGPAGEVYCPSGDKCPLVGSSVPWAFM 510 520 530 540 550 560 780 790 pF1KE1 QGEIATILAGDVKVKKERDP :::::::::::.:::::::: NP_056 QGEIATILAGDIKVKKERDP 570 580 794 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 16:20:16 2016 done: Mon Nov 7 16:20:18 2016 Total Scan time: 12.990 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]