FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3107, 277 aa 1>>>pF1KE3107 277 - 277 aa - 277 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.6192+/-0.000382; mu= 19.0581+/- 0.024 mean_var=66.2959+/-13.489, 0's: 0 Z-trim(112.5): 23 B-trim: 722 in 1/51 Lambda= 0.157518 statistics sampled from 21455 (21478) to 21455 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.637), E-opt: 0.2 (0.252), width: 16 Scan time: 6.630 The best scores are: opt bits E(85289) NP_550438 (OMIM: 251880,601465,617068,617070) deox ( 277) 1842 427.4 1.4e-119 XP_011530949 (OMIM: 251880,601465,617068,617070) P ( 271) 1782 413.8 1.8e-115 NP_001305789 (OMIM: 251880,601465,617068,617070) d ( 180) 1211 283.8 1.5e-76 NP_001305790 (OMIM: 251880,601465,617068,617070) d ( 180) 1211 283.8 1.5e-76 NP_001305792 (OMIM: 251880,601465,617068,617070) d ( 174) 1151 270.2 1.9e-72 NP_001305791 (OMIM: 251880,601465,617068,617070) d ( 174) 1151 270.2 1.9e-72 NP_550440 (OMIM: 251880,601465,617068,617070) deox ( 189) 977 230.7 1.6e-60 NP_001305788 (OMIM: 251880,601465,617068,617070) d ( 183) 936 221.4 1e-57 NP_000779 (OMIM: 125450) deoxycytidine kinase [Hom ( 260) 846 201.0 1.9e-51 NP_001258979 (OMIM: 188250,609560,617069) thymidin ( 168) 289 74.3 1.7e-13 NP_001258863 (OMIM: 188250,609560,617069) thymidin ( 216) 289 74.4 2.1e-13 NP_001166114 (OMIM: 188250,609560,617069) thymidin ( 234) 289 74.4 2.2e-13 NP_001166115 (OMIM: 188250,609560,617069) thymidin ( 240) 289 74.4 2.2e-13 NP_001166116 (OMIM: 188250,609560,617069) thymidin ( 247) 289 74.4 2.3e-13 NP_004605 (OMIM: 188250,609560,617069) thymidine k ( 265) 289 74.5 2.4e-13 NP_001308949 (OMIM: 256000,603835) NADH dehydrogen ( 317) 150 43.0 0.00088 NP_004535 (OMIM: 256000,603835) NADH dehydrogenase ( 355) 150 43.0 0.00095 XP_011509530 (OMIM: 256000,603835) PREDICTED: NADH ( 362) 150 43.0 0.00097 NP_001308948 (OMIM: 256000,603835) NADH dehydrogen ( 375) 150 43.0 0.00099 NP_001258864 (OMIM: 188250,609560,617069) thymidin ( 146) 133 38.8 0.0073 >>NP_550438 (OMIM: 251880,601465,617068,617070) deoxygua (277 aa) initn: 1842 init1: 1842 opt: 1842 Z-score: 2267.7 bits: 427.4 E(85289): 1.4e-119 Smith-Waterman score: 1842; 100.0% identity (100.0% similar) in 277 aa overlap (1-277:1-277) 10 20 30 40 50 60 pF1KE3 MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_550 MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 TYPEWHVATEPVATWQNIQAAGTQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_550 TYPEWHVATEPVATWQNIQAAGTQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 VQLEPFPEKLLQARKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_550 VQLEPFPEKLLQARKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 ASRITLHGFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_550 ASRITLHGFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFE 190 200 210 220 230 240 250 260 270 pF1KE3 ALMNIPVLVLDVNDDFSEEVTKQEDLMREVNTFVKNL ::::::::::::::::::::::::::::::::::::: NP_550 ALMNIPVLVLDVNDDFSEEVTKQEDLMREVNTFVKNL 250 260 270 >>XP_011530949 (OMIM: 251880,601465,617068,617070) PREDI (271 aa) initn: 985 init1: 945 opt: 1782 Z-score: 2194.2 bits: 413.8 E(85289): 1.8e-115 Smith-Waterman score: 1782; 97.8% identity (97.8% similar) in 277 aa overlap (1-277:1-271) 10 20 30 40 50 60 pF1KE3 MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 TYPEWHVATEPVATWQNIQAAGTQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TYPEWHVATEPVATWQNIQAAGTQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 VQLEPFPEKLLQARKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEF :::::::::::::::::::::: :::::::::::::::::::::::::::::::: XP_011 VQLEPFPEKLLQARKPVQIFER------YIFAKNLFENGSLSDIEWHIYQDWHSFLLWEF 130 140 150 160 170 190 200 210 220 230 240 pF1KE3 ASRITLHGFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASRITLHGFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFE 180 190 200 210 220 230 250 260 270 pF1KE3 ALMNIPVLVLDVNDDFSEEVTKQEDLMREVNTFVKNL ::::::::::::::::::::::::::::::::::::: XP_011 ALMNIPVLVLDVNDDFSEEVTKQEDLMREVNTFVKNL 240 250 260 270 >>NP_001305789 (OMIM: 251880,601465,617068,617070) deoxy (180 aa) initn: 1211 init1: 1211 opt: 1211 Z-score: 1495.2 bits: 283.8 E(85289): 1.5e-76 Smith-Waterman score: 1211; 100.0% identity (100.0% similar) in 180 aa overlap (98-277:1-180) 70 80 90 100 110 120 pF1KE3 ATEPVATWQNIQAAGTQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLKVQLEPFP :::::::::::::::::::::::::::::: NP_001 MMYREPARWSYTFQTFSFLSRLKVQLEPFP 10 20 30 130 140 150 160 170 180 pF1KE3 EKLLQARKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEFASRITLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKLLQARKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEFASRITLH 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE3 GFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFEALMNIPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFEALMNIPV 100 110 120 130 140 150 250 260 270 pF1KE3 LVLDVNDDFSEEVTKQEDLMREVNTFVKNL :::::::::::::::::::::::::::::: NP_001 LVLDVNDDFSEEVTKQEDLMREVNTFVKNL 160 170 180 >>NP_001305790 (OMIM: 251880,601465,617068,617070) deoxy (180 aa) initn: 1211 init1: 1211 opt: 1211 Z-score: 1495.2 bits: 283.8 E(85289): 1.5e-76 Smith-Waterman score: 1211; 100.0% identity (100.0% similar) in 180 aa overlap (98-277:1-180) 70 80 90 100 110 120 pF1KE3 ATEPVATWQNIQAAGTQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLKVQLEPFP :::::::::::::::::::::::::::::: NP_001 MMYREPARWSYTFQTFSFLSRLKVQLEPFP 10 20 30 130 140 150 160 170 180 pF1KE3 EKLLQARKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEFASRITLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKLLQARKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEFASRITLH 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE3 GFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFEALMNIPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFEALMNIPV 100 110 120 130 140 150 250 260 270 pF1KE3 LVLDVNDDFSEEVTKQEDLMREVNTFVKNL :::::::::::::::::::::::::::::: NP_001 LVLDVNDDFSEEVTKQEDLMREVNTFVKNL 160 170 180 >>NP_001305792 (OMIM: 251880,601465,617068,617070) deoxy (174 aa) initn: 896 init1: 877 opt: 1151 Z-score: 1421.7 bits: 270.2 E(85289): 1.9e-72 Smith-Waterman score: 1151; 96.7% identity (96.7% similar) in 180 aa overlap (98-277:1-174) 70 80 90 100 110 120 pF1KE3 ATEPVATWQNIQAAGTQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLKVQLEPFP :::::::::::::::::::::::::::::: NP_001 MMYREPARWSYTFQTFSFLSRLKVQLEPFP 10 20 30 130 140 150 160 170 180 pF1KE3 EKLLQARKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEFASRITLH ::::::::::::::: ::::::::::::::::::::::::::::::::::::::: NP_001 EKLLQARKPVQIFER------YIFAKNLFENGSLSDIEWHIYQDWHSFLLWEFASRITLH 40 50 60 70 80 190 200 210 220 230 240 pF1KE3 GFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFEALMNIPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFEALMNIPV 90 100 110 120 130 140 250 260 270 pF1KE3 LVLDVNDDFSEEVTKQEDLMREVNTFVKNL :::::::::::::::::::::::::::::: NP_001 LVLDVNDDFSEEVTKQEDLMREVNTFVKNL 150 160 170 >>NP_001305791 (OMIM: 251880,601465,617068,617070) deoxy (174 aa) initn: 896 init1: 877 opt: 1151 Z-score: 1421.7 bits: 270.2 E(85289): 1.9e-72 Smith-Waterman score: 1151; 96.7% identity (96.7% similar) in 180 aa overlap (98-277:1-174) 70 80 90 100 110 120 pF1KE3 ATEPVATWQNIQAAGTQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLKVQLEPFP :::::::::::::::::::::::::::::: NP_001 MMYREPARWSYTFQTFSFLSRLKVQLEPFP 10 20 30 130 140 150 160 170 180 pF1KE3 EKLLQARKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEFASRITLH ::::::::::::::: ::::::::::::::::::::::::::::::::::::::: NP_001 EKLLQARKPVQIFER------YIFAKNLFENGSLSDIEWHIYQDWHSFLLWEFASRITLH 40 50 60 70 80 190 200 210 220 230 240 pF1KE3 GFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFEALMNIPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFEALMNIPV 90 100 110 120 130 140 250 260 270 pF1KE3 LVLDVNDDFSEEVTKQEDLMREVNTFVKNL :::::::::::::::::::::::::::::: NP_001 LVLDVNDDFSEEVTKQEDLMREVNTFVKNL 150 160 170 >>NP_550440 (OMIM: 251880,601465,617068,617070) deoxygua (189 aa) initn: 974 init1: 974 opt: 977 Z-score: 1207.5 bits: 230.7 E(85289): 1.6e-60 Smith-Waterman score: 1047; 68.2% identity (68.2% similar) in 277 aa overlap (1-277:1-189) 10 20 30 40 50 60 pF1KE3 MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_550 MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 TYPEWHVATEPVATWQNIQAAGTQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_550 TYPEWHVATEPVATWQNIQAAGTQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 VQLEPFPEKLLQARKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEF :::::::::::::::::::::::::::: NP_550 VQLEPFPEKLLQARKPVQIFERSVYSDR-------------------------------- 130 140 190 200 210 220 230 240 pF1KE3 ASRITLHGFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFE :::: NP_550 --------------------------------------------------------LHFE 150 250 260 270 pF1KE3 ALMNIPVLVLDVNDDFSEEVTKQEDLMREVNTFVKNL ::::::::::::::::::::::::::::::::::::: NP_550 ALMNIPVLVLDVNDDFSEEVTKQEDLMREVNTFVKNL 160 170 180 >>NP_001305788 (OMIM: 251880,601465,617068,617070) deoxy (183 aa) initn: 936 init1: 936 opt: 936 Z-score: 1157.4 bits: 221.4 E(85289): 1e-57 Smith-Waterman score: 997; 66.1% identity (66.1% similar) in 277 aa overlap (1-277:1-183) 10 20 30 40 50 60 pF1KE3 MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 TYPEWHVATEPVATWQNIQAAGTQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TYPEWHVATEPVATWQNIQAAGTQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 VQLEPFPEKLLQARKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEF :::::::::::::::::::::: NP_001 VQLEPFPEKLLQARKPVQIFER-------------------------------------- 130 140 190 200 210 220 230 240 pF1KE3 ASRITLHGFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFE :::: NP_001 --------------------------------------------------------LHFE 250 260 270 pF1KE3 ALMNIPVLVLDVNDDFSEEVTKQEDLMREVNTFVKNL ::::::::::::::::::::::::::::::::::::: NP_001 ALMNIPVLVLDVNDDFSEEVTKQEDLMREVNTFVKNL 150 160 170 180 >>NP_000779 (OMIM: 125450) deoxycytidine kinase [Homo sa (260 aa) initn: 835 init1: 671 opt: 846 Z-score: 1044.8 bits: 201.0 E(85289): 1.9e-51 Smith-Waterman score: 846; 47.5% identity (77.9% similar) in 263 aa overlap (18-277:1-260) 10 20 30 40 50 60 pF1KE3 MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTK :: : .. : . : ...:::::::.::::::..: . NP_000 MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQ 10 20 30 40 70 80 90 100 110 pF1KE3 TYPEWHVATEPVATWQNIQAAGTQ---KACTAQSLGNLLDMMYREPARWSYTFQTFSFLS .:.:. :::: : :.:.. . . . .. ::.:.:::..: :::.::::.. :: NP_000 LCEDWEVVPEPVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLS 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE3 RLKVQLEPFPEKLLQARKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLL :...:: . :: .:.::: .:::::::::::::.::.:. ... :: ::::::... NP_000 RIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMN 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE3 WEFASRITLHGFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKL .:.. . : :.:::::.:..::.:.: :.:.::.:: : :::.:: .::.::.:.: : NP_000 NQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKT 170 180 190 200 210 220 240 250 260 270 pF1KE3 HFEALMNIPVLVLDVNDDFSEEVTKQEDLMREVNTFVKNL .:. :...:.:.::::.::.. : :.:...:. :...: NP_000 NFDYLQEVPILTLDVNEDFKD---KYESLVEKVKEFLSTL 230 240 250 260 >>NP_001258979 (OMIM: 188250,609560,617069) thymidine ki (168 aa) initn: 340 init1: 164 opt: 289 Z-score: 363.2 bits: 74.3 E(85289): 1.7e-13 Smith-Waterman score: 328; 35.5% identity (69.0% similar) in 155 aa overlap (99-253:1-141) 70 80 90 100 110 120 pF1KE3 TEPVATWQNIQAAGTQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLKVQLEPFPE ::.. .::. :.::. :. : . .: NP_001 MYHDASRWGLTLQTYVQLTMLDRHTRP--- 10 20 130 140 150 160 170 180 pF1KE3 KLLQARKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEFASRITLHG :. . :...:::..: ::::..::...:.. .... . ..: ...: .. . : NP_001 ---QV-SSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDL-- 30 40 50 60 70 80 190 200 210 220 230 240 pF1KE3 FIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFEALMNIPVL ..::...:..: .:: .: ::::: : : ::: .: :: :::. . : : ::: NP_001 IVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSL---FP--MAAPVL 90 100 110 120 130 250 260 270 pF1KE3 VLDVNDDFSEEVTKQEDLMREVNTFVKNL :.... NP_001 VIEADHHMERMLELFEQNRDRILTPENRKHCP 140 150 160 277 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 16:19:37 2016 done: Mon Nov 7 16:19:38 2016 Total Scan time: 6.630 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]