FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4119, 474 aa 1>>>pF1KE4119 474 - 474 aa - 474 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.9689+/-0.00041; mu= 12.3599+/- 0.025 mean_var=215.8363+/-46.761, 0's: 0 Z-trim(118.3): 245 B-trim: 1356 in 2/58 Lambda= 0.087300 statistics sampled from 30741 (31088) to 30741 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.722), E-opt: 0.2 (0.365), width: 16 Scan time: 9.760 The best scores are: opt bits E(85289) NP_006501 (OMIM: 602165) zinc finger protein RFP [ ( 513) 842 119.2 2.7e-26 NP_660215 (OMIM: 607868) E3 ubiquitin-protein liga ( 468) 816 115.9 2.5e-25 XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 467) 805 114.5 6.5e-25 XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 774 110.6 9.9e-24 NP_057186 (OMIM: 606123) E3 ubiquitin-protein liga ( 477) 774 110.6 9.9e-24 XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 774 110.6 9.9e-24 NP_001020111 (OMIM: 606123) E3 ubiquitin-protein l ( 477) 774 110.6 9.9e-24 XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 774 110.6 9.9e-24 NP_006769 (OMIM: 605701) tripartite motif-containi ( 481) 748 107.3 9.6e-23 NP_001128327 (OMIM: 606123) E3 ubiquitin-protein l ( 343) 745 106.7 1e-22 NP_003132 (OMIM: 109092) E3 ubiquitin-protein liga ( 475) 723 104.2 8.5e-22 XP_016856907 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 713 102.6 1.4e-21 XP_016856908 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 713 102.6 1.4e-21 XP_011512525 (OMIM: 605701) PREDICTED: tripartite ( 499) 702 101.5 5.5e-21 XP_011512523 (OMIM: 605701) PREDICTED: tripartite ( 499) 702 101.5 5.5e-21 XP_011512524 (OMIM: 605701) PREDICTED: tripartite ( 499) 702 101.5 5.5e-21 NP_060543 (OMIM: 613184) E3 ubiquitin-protein liga ( 485) 693 100.4 1.2e-20 XP_011542513 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 450) 669 97.3 9.1e-20 NP_742013 (OMIM: 605700) E3 ubiquitin-protein liga ( 488) 667 97.1 1.1e-19 XP_005253240 (OMIM: 608487) PREDICTED: tripartite ( 493) 656 95.7 3e-19 NP_149023 (OMIM: 608487) tripartite motif-containi ( 493) 656 95.7 3e-19 NP_067629 (OMIM: 605684) tripartite motif-containi ( 488) 634 93.0 2e-18 NP_001003827 (OMIM: 605684) tripartite motif-conta ( 488) 634 93.0 2e-18 NP_439893 (OMIM: 605701) tripartite motif-containi ( 395) 624 91.6 4.3e-18 NP_477514 (OMIM: 607564) tripartite motif-containi ( 488) 617 90.8 9e-18 NP_001003818 (OMIM: 607564) tripartite motif-conta ( 516) 617 90.9 9.3e-18 NP_067076 (OMIM: 605700) E3 ubiquitin-protein liga ( 518) 602 89.0 3.5e-17 NP_892030 (OMIM: 616017) E3 ubiquitin-protein liga ( 500) 601 88.8 3.7e-17 XP_011512527 (OMIM: 605701) PREDICTED: tripartite ( 413) 578 85.8 2.4e-16 NP_976038 (OMIM: 609315) tripartite motif-containi ( 511) 570 84.9 5.6e-16 NP_065091 (OMIM: 606124) tripartite motif-containi ( 452) 559 83.5 1.4e-15 XP_016873951 (OMIM: 608487) PREDICTED: tripartite ( 300) 554 82.6 1.6e-15 NP_149084 (OMIM: 608487) tripartite motif-containi ( 326) 554 82.7 1.7e-15 XP_005253241 (OMIM: 608487) PREDICTED: tripartite ( 326) 554 82.7 1.7e-15 NP_149083 (OMIM: 608487) tripartite motif-containi ( 347) 554 82.7 1.8e-15 XP_016873950 (OMIM: 608487) PREDICTED: tripartite ( 310) 542 81.1 4.8e-15 XP_011518728 (OMIM: 608487) PREDICTED: tripartite ( 310) 542 81.1 4.8e-15 XP_006718421 (OMIM: 608487) PREDICTED: tripartite ( 265) 540 80.8 5.1e-15 XP_016873952 (OMIM: 608487) PREDICTED: tripartite ( 265) 540 80.8 5.1e-15 NP_741983 (OMIM: 617007) tripartite motif-containi ( 493) 544 81.6 5.3e-15 NP_569074 (OMIM: 605684) tripartite motif-containi ( 270) 534 80.0 8.8e-15 XP_011518729 (OMIM: 608487) PREDICTED: tripartite ( 271) 533 79.9 9.6e-15 XP_011512567 (OMIM: 609316) PREDICTED: E3 ubiquiti ( 421) 536 80.5 9.7e-15 NP_008959 (OMIM: 609316) E3 ubiquitin-protein liga ( 425) 536 80.5 9.7e-15 XP_016873949 (OMIM: 608487) PREDICTED: tripartite ( 314) 531 79.7 1.3e-14 XP_011512566 (OMIM: 609316) PREDICTED: E3 ubiquiti ( 424) 532 80.0 1.4e-14 XP_011512568 (OMIM: 609316) PREDICTED: E3 ubiquiti ( 261) 522 78.5 2.5e-14 XP_011542587 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 391) 520 78.5 3.7e-14 NP_006065 (OMIM: 606559) E3 ubiquitin-protein liga ( 498) 518 78.4 5.2e-14 NP_001186502 (OMIM: 606559) E3 ubiquitin-protein l ( 494) 500 76.1 2.5e-13 >>NP_006501 (OMIM: 602165) zinc finger protein RFP [Homo (513 aa) initn: 714 init1: 321 opt: 842 Z-score: 593.0 bits: 119.2 E(85289): 2.7e-26 Smith-Waterman score: 887; 32.9% identity (59.9% similar) in 514 aa overlap (3-471:7-493) 10 20 30 40 50 pF1KE4 MEAEDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNWAPGGGPFPCPECRHPS :: .:.: :::.::.:: .:. ..::::.: .:: : :. . ::.::. NP_006 MASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLARCWGTAETNVSCPQCRETF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 APAALRPNWALARLTEKT-QRRRLGPVPPG----LCGRHWEPLRLFCEDDQRPVCLVCRE .::: :: .:. . : : : :: .: .: :::.:.::.:: :.:.:: . NP_006 PQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDR 70 80 90 100 110 120 120 130 140 150 160 pF1KE4 SQEHQTHAMAPIDEAFESYREKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIKS--- :.::. :.. :..:: :...:.. .: . ..:.: :. . .. : . .. : NP_006 SREHRGHSVLPLEEAVEGFKEQI----QNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQ 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 -QRMRISTEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEV .: .: :: .:.. : :.: .: ::.. . ...: ... .:. :..:: .. NP_006 MEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQFSCNISHLSSLIAQL 180 190 200 210 220 230 230 240 250 260 pF1KE4 GEKSQAPTLELLQNPKEVLTRSE-------------IQD-----------VNYSLEAVKV ::.: :: ::::. ..:.:.: .:. .. ::. NP_006 EEKQQQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEKIHIFAQKCLFLTESLKQFTE 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE4 KTVCQIPLMKEM--LKRFQVAVNLAEDTAHPKLVFSQEGRYVKNTASASSWPVFSSAWNY : .. ..:. . ..: :.: :::.:.:..:.. : :. . .. : NP_006 KMQSDMEKIQELREAQLYSVDVTLDPDTAYPSLILSDNLRQVRYSYLQQDLP-------- 300 310 320 330 340 330 340 350 360 370 pF1KE4 FAGWRNPQKTAFVERFQHLPCVLGKNVFTSGKHYWEVESRDSLEVAVGVCREDVM---GI :: :::. .:::::. : .:.:::::: :. . ..:::...: :. NP_006 ----DNP------ERFNLFPCVLGSPCFIAGRHYWEVEVGDKAKWTIGVCEDSVCRKGGV 350 360 370 380 390 380 390 400 410 420 430 pF1KE4 TDRSKMSPDVGIWAI-YWSAAGYWPLIGFPGTPTQQEPALHRVGVYLDRGTGNVSFYSAV :. .:. :.::. : . :: : . : : . :.:::..:: .:.::::... NP_006 TS----APQNGFWAVSLWYGKEYWALTS-PMTALPLRTPLQRVGIFLDYDAGEVSFYNVT 400 410 420 430 440 450 440 450 460 470 pF1KE4 DGVHLHTFSCSSV-SRLRPFFWLS-----PLASLVIPPVTDRK . : ::: .. . .::.: :: : :.: :.. NP_006 ERCHTFTFSHATFCGPVRPYFSLSYSGGKSAAPLIICPMSGIDGFSGHVGNHGHSMETSP 460 470 480 490 500 510 >>NP_660215 (OMIM: 607868) E3 ubiquitin-protein ligase T (468 aa) initn: 1059 init1: 399 opt: 816 Z-score: 575.7 bits: 115.9 E(85289): 2.5e-25 Smith-Waterman score: 1078; 39.9% identity (64.1% similar) in 471 aa overlap (5-468:9-451) 10 20 30 40 50 pF1KE4 MEAEDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNWAPGGGPFPCPECRHPS ..::: :: :::::: ::: .::::::: :..: :. ::. :::::. : NP_660 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 APAALRPNWALARLTEKTQRRRL---GPVPPGLCGRHWEPLRLFCEDDQRPVCLVCRESQ :::: ::...: . ::: .::: :.: : ::: :: :. : .: .:..: NP_660 PQRNLRPNRPLAKMAEMA--RRLHPPSPVPQGVCPAHREPLAAFCGDELRLLCAACERSG 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 EHQTHAMAPIDEAFESYREKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIKSQRMRI :: .: . :...: :. . :: :: ..: .:. .. .: .. . :. ..:::. . NP_660 EHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNV 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 STEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEVGEKSQA :: .:. .:.:::. .::::..:: :. .: :.. .:.: : : .:: :. . : NP_660 LGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQL 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 PTLELLQNPKEVLTRSEIQDVNYSLEAV---KVKTVCQIPLMKEMLKRFQVAVNLAEDTA :.: :::. :..: : .:::. . : ...:::..: . : :.::. :.: ::: NP_660 PALGLLQDIKDALRR--VQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTA 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 HPKLVFSQEGRYVKNTASASSWPVFSSAWNYFAGWRNPQKTAFVERFQHLPCVLGKNVFT .:.:..:.. : :. .. : .: :::. :::::.. :: NP_660 NPELILSEDRRSVQRGDLRQALP------------DSP------ERFDPGPCVLGQERFT 300 310 320 330 360 370 380 390 400 410 pF1KE4 SGKHYWEVESRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAIYWSAAGYWPLIGFPGTP ::.:::::: : :.:::::.: . .....: :.: . . .. :. .: NP_660 SGRHYWEVEVGDRTSWALGVCRENV-NRKEKGELSAGNGFWILVFLGS-YYNSSERALAP 340 350 360 370 380 390 420 430 440 450 460 pF1KE4 TQQEPALHRVGVYLDRGTGNVSFYSAVDGVHLHTFSCSSVS-RLRPFFWLSPLASLVIPP .. : .:::..:: .:..:::::.:: : : : :::.: :::.: : NP_660 LRDPP--RRVGIFLDYEAGHLSFYSATDGSLLFIFPEIPFSGTLRPLF--SPLSSSPTPM 400 410 420 430 440 450 470 pF1KE4 VTDRK NP_660 TICRPKGGSGDTLAPQ 460 >>XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquitin-pr (467 aa) initn: 923 init1: 416 opt: 805 Z-score: 568.2 bits: 114.5 E(85289): 6.5e-25 Smith-Waterman score: 1067; 39.9% identity (64.1% similar) in 471 aa overlap (5-468:9-450) 10 20 30 40 50 pF1KE4 MEAEDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNWAPGGGPFPCPECRHPS ..::: :: :::::: ::: .::::::: :..: :. ::. :::::. : XP_016 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 APAALRPNWALARLTEKTQRRRL---GPVPPGLCGRHWEPLRLFCEDDQRPVCLVCRESQ :::: ::...: . ::: .::: :.: : ::: :: :. : .: .:..: XP_016 PQRNLRPNRPLAKMAEMA--RRLHPPSPVPQGVCPAHREPLAAFCGDELRLLCAACERSG 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 EHQTHAMAPIDEAFESYREKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIKSQRMRI :: .: . :...: :. . :: :: ..: .:. .. .: .. . :. ..:::. . XP_016 EHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQ-MVESQRQNV 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 STEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEVGEKSQA :: .:. .:.:::. .::::..:: :. .: :.. .:.: : : .:: :. . : XP_016 LGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQL 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 PTLELLQNPKEVLTRSEIQDVNYSLEAV---KVKTVCQIPLMKEMLKRFQVAVNLAEDTA :.: :::. :..: : .:::. . : ...:::..: . : :.::. :.: ::: XP_016 PALGLLQDIKDALRR--VQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTA 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 HPKLVFSQEGRYVKNTASASSWPVFSSAWNYFAGWRNPQKTAFVERFQHLPCVLGKNVFT .:.:..:.. : :. .. : .: :::. :::::.. :: XP_016 NPELILSEDRRSVQRGDLRQALP------------DSP------ERFDPGPCVLGQERFT 300 310 320 330 360 370 380 390 400 410 pF1KE4 SGKHYWEVESRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAIYWSAAGYWPLIGFPGTP ::.:::::: : :.:::::.: . .....: :.: . . .. :. .: XP_016 SGRHYWEVEVGDRTSWALGVCRENV-NRKEKGELSAGNGFWILVFLGS-YYNSSERALAP 340 350 360 370 380 390 420 430 440 450 460 pF1KE4 TQQEPALHRVGVYLDRGTGNVSFYSAVDGVHLHTFSCSSVS-RLRPFFWLSPLASLVIPP .. : .:::..:: .:..:::::.:: : : : :::.: :::.: : XP_016 LRDPP--RRVGIFLDYEAGHLSFYSATDGSLLFIFPEIPFSGTLRPLF--SPLSSSPTPM 400 410 420 430 440 450 470 pF1KE4 VTDRK XP_016 TICRPKGGSGDTLAPQ 460 >>XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (477 aa) initn: 987 init1: 452 opt: 774 Z-score: 547.0 bits: 110.6 E(85289): 9.9e-24 Smith-Waterman score: 1023; 39.0% identity (63.7% similar) in 490 aa overlap (3-471:7-472) 10 20 30 40 pF1KE4 MEAEDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNW--APGG-------GPF :. .::: :: :::::: ::: :::::::.:.. .: : : : : XP_011 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE4 PCPECRHPSAPAALRPNWALARLTEKTQRRRLGPVPPGLCGRHWEPLRLFCEDDQRPVCL ::::::. : : :: :....: .:.. : :: .: :::.:::. :: :.:. XP_011 PCPECREMSPQRNLLPNRLLTKVAEMAQQHP-GLQKQDLCQEHHEPLKLFCQKDQSPICV 70 80 90 100 110 110 120 130 140 150 160 pF1KE4 VCRESQEHQTHAMAPIDEAFESYREKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIK :::::.::. : . : .:: ..:. :: .... : .. .. .:: : .. ..:. :.: XP_011 VCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVK 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 SQRMRISTEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEV .: :: :: :.. .:::::. .:: :. ::::: ..: :.. :.. ::. :.:.. XP_011 ERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQL 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE4 GEKSQAPTLELLQNPKEVLTRSEIQDVNYSLEA--VKVKTVCQIPLMKEMLKRFQVAVNL :.: :..::. :: :.:.. .:. : .. .:::..: . :.:. : : XP_011 EERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVVP 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE4 AEDTAHPKLVF--SQEGRYVKNTASASSWPVFSSAWNYFAGWRNPQKTAFVERFQHLPCV .:.: :.. :.. ::. .. .:. : : .:: ::. XP_011 DATSAYPYLLLYESRQRRYLGSSPEGSG---FCSK----------------DRFVAYPCA 300 310 320 330 340 350 360 370 380 390 400 pF1KE4 LGKNVFTSGKHYWEVE---SRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAIYWSAAGY .:...:.::.::::: . :.: :.::::..: . :: :. :.:.. : : XP_011 VGQTAFSSGRHYWEVGMNITGDALW-ALGVCRDNV-SRKDRVPKCPENGFWVVQLSK-GT 350 360 370 380 390 410 420 430 440 450 pF1KE4 WPLIGFPG-TPTQ-QEPALHRVGVYLDRGTGNVSFYSAVDGVHLHTFSCSSV-SRLRPFF : : . ::.. .:: : .:..:: .:.:::::. :: ::::.: .. . :.::: XP_011 KYLSTFSALTPVMLMEPPSH-MGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFF 400 410 420 430 440 450 460 470 pF1KE4 WLSPLAS--LVIPPVTDRK :. : .:: :: XP_011 CLGAPKSGQMVISTVTMWVKG 460 470 >>NP_057186 (OMIM: 606123) E3 ubiquitin-protein ligase T (477 aa) initn: 987 init1: 452 opt: 774 Z-score: 547.0 bits: 110.6 E(85289): 9.9e-24 Smith-Waterman score: 1023; 39.0% identity (63.7% similar) in 490 aa overlap (3-471:7-472) 10 20 30 40 pF1KE4 MEAEDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNW--APGG-------GPF :. .::: :: :::::: ::: :::::::.:.. .: : : : : NP_057 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE4 PCPECRHPSAPAALRPNWALARLTEKTQRRRLGPVPPGLCGRHWEPLRLFCEDDQRPVCL ::::::. : : :: :....: .:.. : :: .: :::.:::. :: :.:. NP_057 PCPECREMSPQRNLLPNRLLTKVAEMAQQHP-GLQKQDLCQEHHEPLKLFCQKDQSPICV 70 80 90 100 110 110 120 130 140 150 160 pF1KE4 VCRESQEHQTHAMAPIDEAFESYREKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIK :::::.::. : . : .:: ..:. :: .... : .. .. .:: : .. ..:. :.: NP_057 VCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVK 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 SQRMRISTEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEV .: :: :: :.. .:::::. .:: :. ::::: ..: :.. :.. ::. :.:.. NP_057 ERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQL 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE4 GEKSQAPTLELLQNPKEVLTRSEIQDVNYSLEA--VKVKTVCQIPLMKEMLKRFQVAVNL :.: :..::. :: :.:.. .:. : .. .:::..: . :.:. : : NP_057 EERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVVP 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE4 AEDTAHPKLVF--SQEGRYVKNTASASSWPVFSSAWNYFAGWRNPQKTAFVERFQHLPCV .:.: :.. :.. ::. .. .:. : : .:: ::. NP_057 DATSAYPYLLLYESRQRRYLGSSPEGSG---FCSK----------------DRFVAYPCA 300 310 320 330 340 350 360 370 380 390 400 pF1KE4 LGKNVFTSGKHYWEVE---SRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAIYWSAAGY .:...:.::.::::: . :.: :.::::..: . :: :. :.:.. : : NP_057 VGQTAFSSGRHYWEVGMNITGDALW-ALGVCRDNV-SRKDRVPKCPENGFWVVQLSK-GT 350 360 370 380 390 410 420 430 440 450 pF1KE4 WPLIGFPG-TPTQ-QEPALHRVGVYLDRGTGNVSFYSAVDGVHLHTFSCSSV-SRLRPFF : : . ::.. .:: : .:..:: .:.:::::. :: ::::.: .. . :.::: NP_057 KYLSTFSALTPVMLMEPPSH-MGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFF 400 410 420 430 440 450 460 470 pF1KE4 WLSPLAS--LVIPPVTDRK :. : .:: :: NP_057 CLGAPKSGQMVISTVTMWVKG 460 470 >>XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (477 aa) initn: 987 init1: 452 opt: 774 Z-score: 547.0 bits: 110.6 E(85289): 9.9e-24 Smith-Waterman score: 1023; 39.0% identity (63.7% similar) in 490 aa overlap (3-471:7-472) 10 20 30 40 pF1KE4 MEAEDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNW--APGG-------GPF :. .::: :: :::::: ::: :::::::.:.. .: : : : : XP_006 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE4 PCPECRHPSAPAALRPNWALARLTEKTQRRRLGPVPPGLCGRHWEPLRLFCEDDQRPVCL ::::::. : : :: :....: .:.. : :: .: :::.:::. :: :.:. XP_006 PCPECREMSPQRNLLPNRLLTKVAEMAQQHP-GLQKQDLCQEHHEPLKLFCQKDQSPICV 70 80 90 100 110 110 120 130 140 150 160 pF1KE4 VCRESQEHQTHAMAPIDEAFESYREKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIK :::::.::. : . : .:: ..:. :: .... : .. .. .:: : .. ..:. :.: XP_006 VCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVK 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 SQRMRISTEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEV .: :: :: :.. .:::::. .:: :. ::::: ..: :.. :.. ::. :.:.. XP_006 ERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQL 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE4 GEKSQAPTLELLQNPKEVLTRSEIQDVNYSLEA--VKVKTVCQIPLMKEMLKRFQVAVNL :.: :..::. :: :.:.. .:. : .. .:::..: . :.:. : : XP_006 EERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVVP 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE4 AEDTAHPKLVF--SQEGRYVKNTASASSWPVFSSAWNYFAGWRNPQKTAFVERFQHLPCV .:.: :.. :.. ::. .. .:. : : .:: ::. XP_006 DATSAYPYLLLYESRQRRYLGSSPEGSG---FCSK----------------DRFVAYPCA 300 310 320 330 340 350 360 370 380 390 400 pF1KE4 LGKNVFTSGKHYWEVE---SRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAIYWSAAGY .:...:.::.::::: . :.: :.::::..: . :: :. :.:.. : : XP_006 VGQTAFSSGRHYWEVGMNITGDALW-ALGVCRDNV-SRKDRVPKCPENGFWVVQLSK-GT 350 360 370 380 390 410 420 430 440 450 pF1KE4 WPLIGFPG-TPTQ-QEPALHRVGVYLDRGTGNVSFYSAVDGVHLHTFSCSSV-SRLRPFF : : . ::.. .:: : .:..:: .:.:::::. :: ::::.: .. . :.::: XP_006 KYLSTFSALTPVMLMEPPSH-MGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFF 400 410 420 430 440 450 460 470 pF1KE4 WLSPLAS--LVIPPVTDRK :. : .:: :: XP_006 CLGAPKSGQMVISTVTMWVKG 460 470 >>NP_001020111 (OMIM: 606123) E3 ubiquitin-protein ligas (477 aa) initn: 987 init1: 452 opt: 774 Z-score: 547.0 bits: 110.6 E(85289): 9.9e-24 Smith-Waterman score: 1023; 39.0% identity (63.7% similar) in 490 aa overlap (3-471:7-472) 10 20 30 40 pF1KE4 MEAEDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNW--APGG-------GPF :. .::: :: :::::: ::: :::::::.:.. .: : : : : NP_001 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE4 PCPECRHPSAPAALRPNWALARLTEKTQRRRLGPVPPGLCGRHWEPLRLFCEDDQRPVCL ::::::. : : :: :....: .:.. : :: .: :::.:::. :: :.:. NP_001 PCPECREMSPQRNLLPNRLLTKVAEMAQQHP-GLQKQDLCQEHHEPLKLFCQKDQSPICV 70 80 90 100 110 110 120 130 140 150 160 pF1KE4 VCRESQEHQTHAMAPIDEAFESYREKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIK :::::.::. : . : .:: ..:. :: .... : .. .. .:: : .. ..:. :.: NP_001 VCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVK 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 SQRMRISTEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEV .: :: :: :.. .:::::. .:: :. ::::: ..: :.. :.. ::. :.:.. NP_001 ERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQL 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE4 GEKSQAPTLELLQNPKEVLTRSEIQDVNYSLEA--VKVKTVCQIPLMKEMLKRFQVAVNL :.: :..::. :: :.:.. .:. : .. .:::..: . :.:. : : NP_001 EERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVVP 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE4 AEDTAHPKLVF--SQEGRYVKNTASASSWPVFSSAWNYFAGWRNPQKTAFVERFQHLPCV .:.: :.. :.. ::. .. .:. : : .:: ::. NP_001 DATSAYPYLLLYESRQRRYLGSSPEGSG---FCSK----------------DRFVAYPCA 300 310 320 330 340 350 360 370 380 390 400 pF1KE4 LGKNVFTSGKHYWEVE---SRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAIYWSAAGY .:...:.::.::::: . :.: :.::::..: . :: :. :.:.. : : NP_001 VGQTAFSSGRHYWEVGMNITGDALW-ALGVCRDNV-SRKDRVPKCPENGFWVVQLSK-GT 350 360 370 380 390 410 420 430 440 450 pF1KE4 WPLIGFPG-TPTQ-QEPALHRVGVYLDRGTGNVSFYSAVDGVHLHTFSCSSV-SRLRPFF : : . ::.. .:: : .:..:: .:.:::::. :: ::::.: .. . :.::: NP_001 KYLSTFSALTPVMLMEPPSH-MGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFF 400 410 420 430 440 450 460 470 pF1KE4 WLSPLAS--LVIPPVTDRK :. : .:: :: NP_001 CLGAPKSGQMVISTVTMWVKG 460 470 >>XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (477 aa) initn: 987 init1: 452 opt: 774 Z-score: 547.0 bits: 110.6 E(85289): 9.9e-24 Smith-Waterman score: 1023; 39.0% identity (63.7% similar) in 490 aa overlap (3-471:7-472) 10 20 30 40 pF1KE4 MEAEDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNW--APGG-------GPF :. .::: :: :::::: ::: :::::::.:.. .: : : : : XP_011 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE4 PCPECRHPSAPAALRPNWALARLTEKTQRRRLGPVPPGLCGRHWEPLRLFCEDDQRPVCL ::::::. : : :: :....: .:.. : :: .: :::.:::. :: :.:. XP_011 PCPECREMSPQRNLLPNRLLTKVAEMAQQHP-GLQKQDLCQEHHEPLKLFCQKDQSPICV 70 80 90 100 110 110 120 130 140 150 160 pF1KE4 VCRESQEHQTHAMAPIDEAFESYREKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIK :::::.::. : . : .:: ..:. :: .... : .. .. .:: : .. ..:. :.: XP_011 VCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVK 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 SQRMRISTEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEV .: :: :: :.. .:::::. .:: :. ::::: ..: :.. :.. ::. :.:.. XP_011 ERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQL 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE4 GEKSQAPTLELLQNPKEVLTRSEIQDVNYSLEA--VKVKTVCQIPLMKEMLKRFQVAVNL :.: :..::. :: :.:.. .:. : .. .:::..: . :.:. : : XP_011 EERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVVP 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE4 AEDTAHPKLVF--SQEGRYVKNTASASSWPVFSSAWNYFAGWRNPQKTAFVERFQHLPCV .:.: :.. :.. ::. .. .:. : : .:: ::. XP_011 DATSAYPYLLLYESRQRRYLGSSPEGSG---FCSK----------------DRFVAYPCA 300 310 320 330 340 350 360 370 380 390 400 pF1KE4 LGKNVFTSGKHYWEVE---SRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAIYWSAAGY .:...:.::.::::: . :.: :.::::..: . :: :. :.:.. : : XP_011 VGQTAFSSGRHYWEVGMNITGDALW-ALGVCRDNV-SRKDRVPKCPENGFWVVQLSK-GT 350 360 370 380 390 410 420 430 440 450 pF1KE4 WPLIGFPG-TPTQ-QEPALHRVGVYLDRGTGNVSFYSAVDGVHLHTFSCSSV-SRLRPFF : : . ::.. .:: : .:..:: .:.:::::. :: ::::.: .. . :.::: XP_011 KYLSTFSALTPVMLMEPPSH-MGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFF 400 410 420 430 440 450 460 470 pF1KE4 WLSPLAS--LVIPPVTDRK :. : .:: :: XP_011 CLGAPKSGQMVISTVTMWVKG 460 470 >>NP_006769 (OMIM: 605701) tripartite motif-containing p (481 aa) initn: 730 init1: 330 opt: 748 Z-score: 529.3 bits: 107.3 E(85289): 9.6e-23 Smith-Waterman score: 765; 31.5% identity (60.2% similar) in 483 aa overlap (6-459:10-470) 10 20 30 40 50 pF1KE4 MEAEDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNWAPGGGP----FP-CPE . .:..:::: ...::.:.:::::::.:: : . :: : :: NP_006 MASAASVTSLADEVNCPICQGTLREPVTIDCGHNFCRACLTR-YCEIPGPDLEESPTCPL 10 20 30 40 50 60 70 80 90 100 pF1KE4 CRHPSAPAALRPNWALARLTEKTQRRRL----GPVPPGLCGRHWEPLRLFCEDDQRPVCL :..: :...:::: :: ..:. .: .: : .: .: : . .:::::. .:. NP_006 CKEPFRPGSFRPNWQLANVVENIERLQLVSTLGLGEEDVCQEHGEKIYFFCEDDEMQLCV 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE4 VCRESQEHQTHAMAPIDEAFESYREKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIK ::::. :: ::.: ...: :::.. : . : . ......:. : : ... NP_006 VCREAGEHATHTMRFLEDAAAPYREQIHKCLKCLRKEREEIQEIQSRENKRMQVLLTQVS 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 SQRMRISTEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEV ..:... .::..:..:: :.....: .:.... . .. .: : . : .. :: :. NP_006 TKRQQVISEFAHLRKFLEEQQSILLAQLESQDGDILRQRDEFDLLVAGEICRFSALIEEL 180 190 200 210 220 230 230 240 250 260 270 pF1KE4 GEKSQAPTLELLQNPKEVLTRSEI----QDVNYSLE-AVKVKTVCQ--IPLMKEM---LK ::.. :. ::: . . .: : : . : : : . ... : .::..:: :. NP_006 EEKNERPARELLTDIRSTLIRCETRKCRKPVAVSPELGQRIRDFPQQALPLQREMKMFLE 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE4 R--FQVA-----VNLAEDTAHPKLVFSQEGRYVKNTASASSWPVFSSAWNYFAGWRNPQK . :.. ..: .:.::::..:.. . .. :: :. . ::: NP_006 KLCFELDYEPAHISLDPQTSHPKLLLSEDHQRAQ----------FSYKWQ--NSPDNPQ- 300 310 320 330 340 340 350 360 370 380 pF1KE4 TAFVERFQHLPCVLGKNVFTSGKHYW--EVESRDSLEVAVGVCREDVMGITDRSKMSPDV ::.. :::... .:.:.: : .. . .::: :::. . .. :. NP_006 -----RFDRATCVLAHTGITGGRHTWVVSIDLAHGGSCTVGVVSEDVQR-KGELRLRPEE 350 360 370 380 390 400 390 400 410 420 430 440 pF1KE4 GIWAIYWSAAGYWPLIG-FPGTPTQQEPALHRVGVYLDRGTGNVSFYSAVDGVHLHTFSC :.::. : :. .: :: : .: ..: : :: .: :.: .:: ..::. NP_006 GVWAVRL-AWGFVSALGSFPTRLTLKEQP-RQVRVSLDYEVGWVTFTNAVTREPIYTFTA 410 420 430 440 450 450 460 470 pF1KE4 SSVSRLRPFFWLSPLASLVIPPVTDRK : . .. ::: : NP_006 SFTRKVIPFFGLWGRGSSFSLSS 460 470 480 >>NP_001128327 (OMIM: 606123) E3 ubiquitin-protein ligas (343 aa) initn: 724 init1: 452 opt: 745 Z-score: 528.9 bits: 106.7 E(85289): 1e-22 Smith-Waterman score: 745; 41.7% identity (67.7% similar) in 288 aa overlap (3-279:7-293) 10 20 30 40 pF1KE4 MEAEDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNW--APGG-------GPF :. .::: :: :::::: ::: :::::::.:.. .: : : : : NP_001 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE4 PCPECRHPSAPAALRPNWALARLTEKTQRRRLGPVPPGLCGRHWEPLRLFCEDDQRPVCL ::::::. : : :: :....: .:.. : :: .: :::.:::. :: :.:. NP_001 PCPECREMSPQRNLLPNRLLTKVAEMAQQHP-GLQKQDLCQEHHEPLKLFCQKDQSPICV 70 80 90 100 110 110 120 130 140 150 160 pF1KE4 VCRESQEHQTHAMAPIDEAFESYREKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIK :::::.::. : . : .:: ..:. :: .... : .. .. .:: : .. ..:. :.: NP_001 VCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVK 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 SQRMRISTEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEV .: :: :: :.. .:::::. .:: :. ::::: ..: :.. :.. ::. :.:.. NP_001 ERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQL 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE4 GEKSQAPTLELLQNPKEVLTRSEIQDVNYSLEA--VKVKTVCQIPLMKEMLKRFQVAVNL :.: :..::. :: :.:.. .:. : .. .:::..: . :.:. : NP_001 EERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLGKWAP 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE4 AEDTAHPKLVFSQEGRYVKNTASASSWPVFSSAWNYFAGWRNPQKTAFVERFQHLPCVLG NP_001 RARTSDPGSLGDAPLYPLASEATNGGGSTSALPGDGHWLFTVPS 300 310 320 330 340 474 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 16:13:45 2016 done: Mon Nov 7 16:13:47 2016 Total Scan time: 9.760 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]