FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3325, 921 aa 1>>>pF1KE3325 921 - 921 aa - 921 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.6844+/-0.00046; mu= -9.5555+/- 0.029 mean_var=613.2849+/-133.013, 0's: 0 Z-trim(123.4): 296 B-trim: 33 in 1/57 Lambda= 0.051790 statistics sampled from 42877 (43274) to 42877 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.778), E-opt: 0.2 (0.507), width: 16 Scan time: 15.260 The best scores are: opt bits E(85289) NP_775869 (OMIM: 610737) kinase suppressor of Ras ( 921) 6375 492.1 5.4e-138 XP_011536526 (OMIM: 610737) PREDICTED: kinase supp ( 948) 6343 489.7 2.9e-137 XP_016874697 (OMIM: 610737) PREDICTED: kinase supp ( 936) 6047 467.6 1.3e-130 XP_011536527 (OMIM: 610737) PREDICTED: kinase supp ( 829) 5788 448.2 8e-125 XP_011536528 (OMIM: 610737) PREDICTED: kinase supp ( 742) 4937 384.5 1e-105 XP_011536530 (OMIM: 610737) PREDICTED: kinase supp ( 647) 4296 336.6 2.5e-91 XP_011536531 (OMIM: 610737) PREDICTED: kinase supp ( 619) 4118 323.2 2.4e-87 XP_016874698 (OMIM: 610737) PREDICTED: kinase supp ( 620) 4022 316.1 3.5e-85 XP_016874699 (OMIM: 610737) PREDICTED: kinase supp ( 515) 3497 276.7 2e-73 XP_016880756 (OMIM: 601132) PREDICTED: kinase supp ( 909) 2183 178.9 1e-43 XP_016880758 (OMIM: 601132) PREDICTED: kinase supp ( 876) 1948 161.3 1.9e-38 XP_016880757 (OMIM: 601132) PREDICTED: kinase supp ( 901) 1946 161.1 2.2e-38 NP_055053 (OMIM: 601132) kinase suppressor of Ras ( 762) 1701 142.8 6.4e-33 XP_011523732 (OMIM: 601132) PREDICTED: kinase supp ( 899) 1701 142.8 7.1e-33 XP_016880767 (OMIM: 601132) PREDICTED: kinase supp ( 587) 1694 142.1 7.7e-33 XP_016880766 (OMIM: 601132) PREDICTED: kinase supp ( 605) 1694 142.1 7.9e-33 XP_011523733 (OMIM: 601132) PREDICTED: kinase supp ( 898) 1696 142.5 9.2e-33 XP_016880764 (OMIM: 601132) PREDICTED: kinase supp ( 786) 1694 142.2 9.4e-33 XP_016880763 (OMIM: 601132) PREDICTED: kinase supp ( 786) 1694 142.2 9.4e-33 XP_016880765 (OMIM: 601132) PREDICTED: kinase supp ( 786) 1694 142.2 9.4e-33 XP_016880762 (OMIM: 601132) PREDICTED: kinase supp ( 786) 1694 142.2 9.4e-33 XP_016880760 (OMIM: 601132) PREDICTED: kinase supp ( 786) 1694 142.2 9.4e-33 XP_016880761 (OMIM: 601132) PREDICTED: kinase supp ( 786) 1694 142.2 9.4e-33 XP_016880759 (OMIM: 601132) PREDICTED: kinase supp ( 804) 1694 142.3 9.5e-33 XP_011523731 (OMIM: 601132) PREDICTED: kinase supp ( 923) 1694 142.3 1e-32 XP_006722217 (OMIM: 601132) PREDICTED: kinase supp ( 887) 1689 141.9 1.3e-32 XP_016868047 (OMIM: 115150,163950,164757,211980,61 ( 807) 643 63.7 4.1e-09 XP_016868048 (OMIM: 115150,163950,164757,211980,61 ( 798) 615 61.6 1.8e-08 NP_004324 (OMIM: 115150,163950,164757,211980,61370 ( 766) 595 60.1 4.8e-08 XP_005250102 (OMIM: 115150,163950,164757,211980,61 ( 767) 595 60.1 4.8e-08 XP_016880769 (OMIM: 601132) PREDICTED: kinase supp ( 524) 581 58.9 7.7e-08 XP_016880768 (OMIM: 601132) PREDICTED: kinase supp ( 541) 575 58.4 1.1e-07 XP_011542211 (OMIM: 311010) PREDICTED: serine/thre ( 387) 547 56.2 3.7e-07 XP_006724592 (OMIM: 311010) PREDICTED: serine/thre ( 611) 549 56.6 4.5e-07 XP_011542208 (OMIM: 311010) PREDICTED: serine/thre ( 611) 549 56.6 4.5e-07 NP_001243125 (OMIM: 311010) serine/threonine-prote ( 609) 548 56.5 4.7e-07 NP_001645 (OMIM: 311010) serine/threonine-protein ( 606) 547 56.4 5e-07 XP_011542210 (OMIM: 311010) PREDICTED: serine/thre ( 606) 547 56.4 5e-07 XP_005265416 (OMIM: 164760,611553,611554,615916) P ( 534) 511 53.7 2.9e-06 XP_005265415 (OMIM: 164760,611553,611554,615916) P ( 567) 511 53.7 3.1e-06 XP_011532277 (OMIM: 164760,611553,611554,615916) P ( 567) 511 53.7 3.1e-06 XP_005265414 (OMIM: 164760,611553,611554,615916) P ( 615) 511 53.7 3.2e-06 XP_016862455 (OMIM: 164760,611553,611554,615916) P ( 615) 511 53.7 3.2e-06 XP_005265412 (OMIM: 164760,611553,611554,615916) P ( 648) 511 53.8 3.3e-06 NP_002871 (OMIM: 164760,611553,611554,615916) RAF ( 648) 511 53.8 3.3e-06 XP_011532276 (OMIM: 164760,611553,611554,615916) P ( 648) 511 53.8 3.3e-06 NP_002437 (OMIM: 600137) mitogen-activated protein ( 954) 376 43.9 0.0047 >>NP_775869 (OMIM: 610737) kinase suppressor of Ras 2 [H (921 aa) initn: 6375 init1: 6375 opt: 6375 Z-score: 2598.4 bits: 492.1 E(85289): 5.4e-138 Smith-Waterman score: 6375; 100.0% identity (100.0% similar) in 921 aa overlap (1-921:1-921) 10 20 30 40 50 60 pF1KE3 MIDLSISNLEGLRTKCATSNDLTQKEIRTLESKLVKYFSRQLSCKKKVALQERNAELDGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 MIDLSISNLEGLRTKCATSNDLTQKEIRTLESKLVKYFSRQLSCKKKVALQERNAELDGF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 PQLRHWFRIVDVRKEVLEEISPGQLSLEDLLEMTDEQVCETVEKYGANREECARLNASLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 PQLRHWFRIVDVRKEVLEEISPGQLSLEDLLEMTDEQVCETVEKYGANREECARLNASLS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 CLRNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHLSQSPRVPSKCVQHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 CLRNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHLSQSPRVPSKCVQHY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 CHTSPTPGAPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 CHTSPTPGAPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 TVTPPGTPPMRKKNKLKPPGTPPPSSRKLIHLIPGFTALHRSKSHEFQLGHRVDEAHTPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 TVTPPGTPPMRKKNKLKPPGTPPPSSRKLIHLIPGFTALHRSKSHEFQLGHRVDEAHTPK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 AKKKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHTEANFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 AKKKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHTEANFS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 ANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 ANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 TKEAPPCHLLIIHRGDPARLVRTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 TKEAPPCHLLIIHRGDPARLVRTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 PVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 PVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKY 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 KQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 KQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 DDFEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 DDFEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 AIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 AIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 VVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 VVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSI 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 SGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 SGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHA 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE3 REWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 REWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLE 850 860 870 880 890 900 910 920 pF1KE3 KLPKRNRRLSHPGHFWKSAEL ::::::::::::::::::::: NP_775 KLPKRNRRLSHPGHFWKSAEL 910 920 >>XP_011536526 (OMIM: 610737) PREDICTED: kinase suppress (948 aa) initn: 6343 init1: 3306 opt: 6343 Z-score: 2585.4 bits: 489.7 E(85289): 2.9e-137 Smith-Waterman score: 6343; 99.8% identity (99.8% similar) in 921 aa overlap (1-921:30-948) 10 20 30 pF1KE3 MIDLSISNLEGLRTKCATSNDLTQKEIRTLE ::::::::::::::::::::::::::::::: XP_011 MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE3 SKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLL 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE3 EMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENN 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE3 PVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPP 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE3 LESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIH 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE3 LIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLL 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE3 SERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYW 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE3 MSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDIN :::::::::::::::::::::::::::::::::::::::::::: :::::::::::::: XP_011 MSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRG--ARLVRTESVPCDIN 430 440 450 460 470 460 470 480 490 500 510 pF1KE3 NPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSA 480 490 500 510 520 530 520 530 540 550 560 570 pF1KE3 TPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNP 540 550 560 570 580 590 580 590 600 610 620 630 pF1KE3 ILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWD 600 610 620 630 640 650 640 650 660 670 680 690 pF1KE3 IPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHE 660 670 680 690 700 710 700 710 720 730 740 750 pF1KE3 NVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAK 720 730 740 750 760 770 760 770 780 790 800 810 pF1KE3 GILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQL 780 790 800 810 820 830 820 830 840 850 860 870 pF1KE3 SPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMG 840 850 860 870 880 890 880 890 900 910 920 pF1KE3 KEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL 900 910 920 930 940 >>XP_016874697 (OMIM: 610737) PREDICTED: kinase suppress (936 aa) initn: 6046 init1: 6046 opt: 6047 Z-score: 2465.9 bits: 467.6 E(85289): 1.3e-130 Smith-Waterman score: 6047; 97.4% identity (98.0% similar) in 906 aa overlap (1-905:30-930) 10 20 30 pF1KE3 MIDLSISNLEGLRTKCATSNDLTQKEIRTLE ::::::::::::::::::::::::::::::: XP_016 MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE3 SKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLL 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE3 EMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENN 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE3 PVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPP 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE3 LESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIH 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE3 LIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLL 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE3 SERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYW 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE3 MSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDIN 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE3 NPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSA 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE3 TPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNP 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE3 ILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWD 610 620 630 640 650 660 640 650 660 670 680 690 pF1KE3 IPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHE 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE3 NVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAK 730 740 750 760 770 780 760 770 780 790 800 810 pF1KE3 GILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQL 790 800 810 820 830 840 820 830 840 850 860 870 pF1KE3 SPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMG 850 860 870 880 890 900 880 890 900 910 920 pF1KE3 KEIS-DILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL :::: . . : : : : .. ::. :. XP_016 KEISGSYSIEIWM----ETPGFP-FIPSLERNVKKLFGKYC 910 920 930 >>XP_011536527 (OMIM: 610737) PREDICTED: kinase suppress (829 aa) initn: 5788 init1: 5788 opt: 5788 Z-score: 2361.9 bits: 448.2 E(85289): 8e-125 Smith-Waterman score: 5788; 100.0% identity (100.0% similar) in 829 aa overlap (93-921:1-829) 70 80 90 100 110 120 pF1KE3 LRHWFRIVDVRKEVLEEISPGQLSLEDLLEMTDEQVCETVEKYGANREECARLNASLSCL :::::::::::::::::::::::::::::: XP_011 MTDEQVCETVEKYGANREECARLNASLSCL 10 20 30 130 140 150 160 170 180 pF1KE3 RNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHLSQSPRVPSKCVQHYCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHLSQSPRVPSKCVQHYCH 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE3 TSPTPGAPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVTTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSPTPGAPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVTTV 100 110 120 130 140 150 250 260 270 280 290 300 pF1KE3 TPPGTPPMRKKNKLKPPGTPPPSSRKLIHLIPGFTALHRSKSHEFQLGHRVDEAHTPKAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPPGTPPMRKKNKLKPPGTPPPSSRKLIHLIPGFTALHRSKSHEFQLGHRVDEAHTPKAK 160 170 180 190 200 210 310 320 330 340 350 360 pF1KE3 KKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHTEANFSAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHTEANFSAN 220 230 240 250 260 270 370 380 390 400 410 420 pF1KE3 TLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTK 280 290 300 310 320 330 430 440 450 460 470 480 pF1KE3 EAPPCHLLIIHRGDPARLVRTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAPPCHLLIIHRGDPARLVRTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPV 340 350 360 370 380 390 490 500 510 520 530 540 pF1KE3 PYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKYKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKYKQ 400 410 420 430 440 450 550 560 570 580 590 600 pF1KE3 QFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESEDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESEDD 460 470 480 490 500 510 610 620 630 640 650 660 pF1KE3 FEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAI 520 530 540 550 560 570 670 680 690 700 710 720 pF1KE3 RLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVV 580 590 600 610 620 630 730 740 750 760 770 780 pF1KE3 RDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISG 640 650 660 670 680 690 790 800 810 820 830 840 pF1KE3 VLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHARE 700 710 720 730 740 750 850 860 870 880 890 900 pF1KE3 WPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKL 760 770 780 790 800 810 910 920 pF1KE3 PKRNRRLSHPGHFWKSAEL ::::::::::::::::::: XP_011 PKRNRRLSHPGHFWKSAEL 820 >>XP_011536528 (OMIM: 610737) PREDICTED: kinase suppress (742 aa) initn: 4937 init1: 4937 opt: 4937 Z-score: 2018.9 bits: 384.5 E(85289): 1e-105 Smith-Waterman score: 4937; 100.0% identity (100.0% similar) in 710 aa overlap (1-710:30-739) 10 20 30 pF1KE3 MIDLSISNLEGLRTKCATSNDLTQKEIRTLE ::::::::::::::::::::::::::::::: XP_011 MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE3 SKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLL 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE3 EMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENN 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE3 PVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPP 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE3 LESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIH 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE3 LIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLL 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE3 SERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYW 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE3 MSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDIN 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE3 NPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSA 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE3 TPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNP 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE3 ILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWD 610 620 630 640 650 660 640 650 660 670 680 690 pF1KE3 IPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHE 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE3 NVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAK ::::::::::::::::::: XP_011 NVVLFMGACMSPPHLAIITRPV 730 740 >>XP_011536530 (OMIM: 610737) PREDICTED: kinase suppress (647 aa) initn: 4296 init1: 4296 opt: 4296 Z-score: 1760.7 bits: 336.6 E(85289): 2.5e-91 Smith-Waterman score: 4296; 99.8% identity (100.0% similar) in 623 aa overlap (299-921:25-647) 270 280 290 300 310 320 pF1KE3 LIHLIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRS :.:::::::::::::::::::::::::::: XP_011 MYNKKAKMEPNASESAIPARRQRQPRAKKKSKPLNLKIHSSVGSCENIPSQQRS 10 20 30 40 50 330 340 350 360 370 380 pF1KE3 PLLSERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLLSERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFST 60 70 80 90 100 110 390 400 410 420 430 440 pF1KE3 KYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPC 120 130 140 150 160 170 450 460 470 480 490 500 pF1KE3 DINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLP 180 190 200 210 220 230 510 520 530 540 550 560 pF1KE3 PSATPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSATPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVT 240 250 260 270 280 290 570 580 590 600 610 620 pF1KE3 SNPILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SNPILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQ 300 310 320 330 340 350 630 640 650 660 670 680 pF1KE3 EWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQT 360 370 380 390 400 410 690 700 710 720 730 740 pF1KE3 RHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYL 420 430 440 450 460 470 750 760 770 780 790 800 pF1KE3 HAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEII 480 490 500 510 520 530 810 820 830 840 850 860 pF1KE3 RQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQI 540 550 560 570 580 590 870 880 890 900 910 920 pF1KE3 GMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL 600 610 620 630 640 >>XP_011536531 (OMIM: 610737) PREDICTED: kinase suppress (619 aa) initn: 4118 init1: 4118 opt: 4118 Z-score: 1689.1 bits: 323.2 E(85289): 2.4e-87 Smith-Waterman score: 4118; 100.0% identity (100.0% similar) in 588 aa overlap (1-588:30-617) 10 20 30 pF1KE3 MIDLSISNLEGLRTKCATSNDLTQKEIRTLE ::::::::::::::::::::::::::::::: XP_011 MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE3 SKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLL 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE3 EMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENN 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE3 PVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPP 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE3 LESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIH 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE3 LIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLL 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE3 SERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYW 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE3 MSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDIN 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE3 NPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSA 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE3 TPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNP 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE3 ILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWD ::::::::::::::::: XP_011 ILEGNPLLQIEVEPTSEPV 610 >>XP_016874698 (OMIM: 610737) PREDICTED: kinase suppress (620 aa) initn: 4022 init1: 4022 opt: 4022 Z-score: 1650.3 bits: 316.1 E(85289): 3.5e-85 Smith-Waterman score: 4022; 100.0% identity (100.0% similar) in 573 aa overlap (1-573:30-602) 10 20 30 pF1KE3 MIDLSISNLEGLRTKCATSNDLTQKEIRTLE ::::::::::::::::::::::::::::::: XP_016 MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE3 SKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLL 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE3 EMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENN 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE3 PVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPP 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE3 LESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIH 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE3 LIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLL 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE3 SERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYW 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE3 MSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDIN 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE3 NPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSA 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE3 TPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNP 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE3 ILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWD :: XP_016 ILTWYISEIKGAATCRGIWC 610 620 >>XP_016874699 (OMIM: 610737) PREDICTED: kinase suppress (515 aa) initn: 3497 init1: 3497 opt: 3497 Z-score: 1439.3 bits: 276.7 E(85289): 2e-73 Smith-Waterman score: 3497; 99.8% identity (100.0% similar) in 509 aa overlap (413-921:7-515) 390 400 410 420 430 440 pF1KE3 KHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVR .::::::::::::::::::::::::::::: XP_016 MFVPLVRLKCHNKCTKEAPPCHLLIIHRGDPARLVR 10 20 30 450 460 470 480 490 500 pF1KE3 TESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSS 40 50 60 70 80 90 510 520 530 540 550 560 pF1KE3 PAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQV 100 110 120 130 140 150 570 580 590 600 610 620 pF1KE3 ILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQ 160 170 180 190 200 210 630 640 650 660 670 680 pF1KE3 TSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREV 220 230 240 250 260 270 690 700 710 720 730 740 pF1KE3 MAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIV 280 290 300 310 320 330 750 760 770 780 790 800 pF1KE3 KGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCH 340 350 360 370 380 390 810 820 830 840 850 860 pF1KE3 LAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMK 400 410 420 430 440 450 870 880 890 900 910 920 pF1KE3 PNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL 460 470 480 490 500 510 >>XP_016880756 (OMIM: 601132) PREDICTED: kinase suppress (909 aa) initn: 2413 init1: 1305 opt: 2183 Z-score: 905.8 bits: 178.9 E(85289): 1e-43 Smith-Waterman score: 2722; 49.2% identity (70.8% similar) in 941 aa overlap (1-921:47-885) 10 20 30 pF1KE3 MIDLSISNLEGLRTKCATSNDLTQKEIRTL .::.::..:.:::::::.::::::.::::: XP_016 GGGGGDAAAAEGGAGAAASRALQQCGQLQKLIDISIGSLRGLRTKCAVSNDLTQQEIRTL 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE3 ESKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDL :.:::.:. .: .:: .:: ::. ::...:.. :. .:: ::..:: : .:.:. : XP_016 EAKLVRYICKQRQCKLSVAPGERTPELNSYPRFSDWLYTFNVRPEVVQEI-PRDLTLDAL 80 90 100 110 120 130 100 110 120 130 140 150 pF1KE3 LEMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKEN :::.. .: ::... ::. .::.::. .:.:::.: ::. :.: . : . .. .:. XP_016 LEMNEAKVKETLRRCGASGDECGRLQYALTCLRKVTGLGGE-HKEDSS--WSSLDARRES 140 150 160 170 180 190 160 170 180 190 200 210 pF1KE3 NPVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPP . : . : : :. . . ... : . ..:.: :. : XP_016 G--SGPSTDTLSAASLPWPP--GSSQLGRAGNSAQGPRS--------ISVSALPASDSPT 200 210 220 230 240 220 230 240 250 260 pF1KE3 PLESGHRSLPPSPRQRHAV-RTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKL : : ..: . :: : ::. . . .::: :: .:...::::: :::: :::. XP_016 P--SFSEGLSDTCIPLHASGRLTPRA--LHSFITPPTTPQLRRHTKLKPPRTPPPPSRKV 250 260 270 280 290 270 280 290 300 310 320 pF1KE3 IHLIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSP ..:.:.: .: :::::: :::.:.:.. XP_016 FQLLPSFPTLTRSKSHESQLGNRIDDVS-------------------------------- 300 310 320 330 340 350 360 370 380 pF1KE3 LLSERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTK :.: : ..:. :::. :::.: :. :::::: XP_016 -----SMR-FDLSHG-------------------------SPQMVRRDIGLSVTHRFSTK 330 340 350 390 400 410 420 430 440 pF1KE3 YWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDP-ARLVRTESVPC :.::.: :: :.:.::.:::.:.:::::::::::: :.. .. : .:: :::::: XP_016 SWLSQVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFL----PLTRLRRTESVPS 360 370 380 390 400 450 460 470 480 490 500 pF1KE3 DINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLP :::::. : .. :.. ::::. .:.: :. . ::::::::::::::::::: .: XP_016 DINNPV---DRAAEPHFG-TLPKA-LTKKEHPPAMNHLDSSSNPSSTTSSTPSSPAP-FP 410 420 430 440 450 460 510 520 530 540 550 pF1KE3 PSATPPS---PLHPSPQCTRQQKNFNLP-ASHYYK--------YKQQF---IFPDVVPVP :..: : : .::: .. :: .: :.: .: .. : : ..:.: XP_016 TSSNPSSATTPPNPSPGQRDSRFNFPVPSAGHCWKCLLIAESLKENAFNISAFAHAAPLP 470 480 490 500 510 520 560 570 580 590 600 610 pF1KE3 ETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSA :. : . : . .::.. . :.: : : ..:::..::. ... : XP_016 EA---ADGTRLDDQPKADVLEAH---EAEAE---EPEAGKSEAEDDEDEVDDLPSSRRPW 530 540 550 560 570 620 630 640 650 660 670 pF1KE3 RS-FPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNE :. . :::::::..::::::::::.:.:: ::.::.:.:..:::::::::::.... :. XP_016 RGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQ 580 590 600 610 620 630 680 690 700 710 720 730 pF1KE3 DQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVN :.:: ::.::: :::::::::::::::::.:::::::::.::::::.: ::: : ::.: XP_016 DHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDIN 640 650 660 670 680 690 740 750 760 770 780 790 pF1KE3 KTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDK :::::::::.:::::::::::.::::::::::::::::::::::::.::::.. ::::.. XP_016 KTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREGRRENQ 700 710 720 730 740 750 800 810 820 830 840 850 pF1KE3 LRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEA :.... :::.:::::.:...: .::.::::: .::.:.::.::::.::.::.:.: ::: XP_016 LKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEA 760 770 780 790 800 810 860 870 880 890 900 910 pF1KE3 IIWQMGTG--MKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLS :::.:.: :: :.....:::.:.:: ::::. .:::.:. :::::::::: ::::: XP_016 SIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLPKLNRRLS 820 830 840 850 860 870 920 pF1KE3 HPGHFWKSAEL :::::::::.. XP_016 HPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM 880 890 900 921 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 16:12:15 2016 done: Mon Nov 7 16:12:17 2016 Total Scan time: 15.260 Total Display time: 0.270 Function used was FASTA [36.3.4 Apr, 2011]