FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3312, 795 aa 1>>>pF1KE3312 795 - 795 aa - 795 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.1985+/-0.000602; mu= 4.4368+/- 0.037 mean_var=556.2175+/-121.226, 0's: 0 Z-trim(117.8): 2039 B-trim: 33 in 1/55 Lambda= 0.054382 statistics sampled from 27271 (30052) to 27271 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.683), E-opt: 0.2 (0.352), width: 16 Scan time: 11.810 The best scores are: opt bits E(85289) XP_006713373 (OMIM: 601959) PREDICTED: serine/thre ( 795) 5220 426.0 3.2e-118 XP_016862575 (OMIM: 601959) PREDICTED: serine/thre ( 824) 5025 410.7 1.3e-113 XP_011532342 (OMIM: 601959) PREDICTED: serine/thre ( 671) 3047 255.4 6.1e-67 NP_003148 (OMIM: 601959) serine/threonine-protein ( 841) 3047 255.5 6.8e-67 XP_011532341 (OMIM: 601959) PREDICTED: serine/thre ( 842) 3047 255.5 6.8e-67 XP_016862574 (OMIM: 601959) PREDICTED: serine/thre ( 870) 3047 255.6 6.9e-67 NP_001180462 (OMIM: 601959) serine/threonine-prote ( 752) 2256 193.4 3.1e-48 XP_011530306 (OMIM: 263520,604588) PREDICTED: seri (1214) 988 94.3 3.5e-18 NP_001186329 (OMIM: 263520,604588) serine/threonin (1214) 988 94.3 3.5e-18 XP_011530307 (OMIM: 263520,604588) PREDICTED: seri ( 715) 979 93.2 4.3e-18 NP_001186328 (OMIM: 263520,604588) serine/threonin (1189) 979 93.5 5.6e-18 XP_006714291 (OMIM: 263520,604588) PREDICTED: seri (1227) 979 93.6 5.7e-18 NP_001186327 (OMIM: 263520,604588) serine/threonin (1242) 979 93.6 5.7e-18 NP_036356 (OMIM: 263520,604588) serine/threonine-p (1258) 979 93.6 5.8e-18 XP_011530305 (OMIM: 263520,604588) PREDICTED: seri (1258) 979 93.6 5.8e-18 NP_001186326 (OMIM: 263520,604588) serine/threonin (1286) 979 93.6 5.8e-18 NP_001139571 (OMIM: 604044) serine/threonine-prote ( 489) 848 82.6 4.5e-15 XP_011533370 (OMIM: 616731) PREDICTED: serine/thre ( 483) 846 82.5 4.9e-15 XP_006719871 (OMIM: 616731) PREDICTED: serine/thre ( 598) 846 82.6 5.5e-15 XP_011533368 (OMIM: 616731) PREDICTED: serine/thre ( 697) 846 82.7 5.9e-15 NP_689933 (OMIM: 604044) serine/threonine-protein ( 506) 843 82.3 6e-15 NP_002489 (OMIM: 604044) serine/threonine-protein ( 506) 843 82.3 6e-15 NP_954983 (OMIM: 616731) serine/threonine-protein ( 708) 846 82.7 6e-15 XP_016876045 (OMIM: 616731) PREDICTED: serine/thre ( 737) 846 82.8 6.1e-15 XP_016876044 (OMIM: 616731) PREDICTED: serine/thre ( 755) 846 82.8 6.2e-15 XP_016876046 (OMIM: 616731) PREDICTED: serine/thre ( 780) 846 82.8 6.3e-15 NP_665917 (OMIM: 609779) serine/threonine-protein ( 470) 788 77.9 1.1e-13 NP_001139475 (OMIM: 609779) serine/threonine-prote ( 599) 790 78.2 1.2e-13 XP_016862702 (OMIM: 609779) PREDICTED: serine/thre ( 599) 790 78.2 1.2e-13 XP_016862703 (OMIM: 609779) PREDICTED: serine/thre ( 599) 790 78.2 1.2e-13 NP_001308152 (OMIM: 609779) serine/threonine-prote ( 482) 788 77.9 1.2e-13 XP_011511469 (OMIM: 609779) PREDICTED: serine/thre ( 645) 790 78.3 1.2e-13 NP_001308149 (OMIM: 609779) serine/threonine-prote ( 645) 790 78.3 1.2e-13 NP_079076 (OMIM: 609779) serine/threonine-protein ( 645) 790 78.3 1.2e-13 XP_016862704 (OMIM: 609779) PREDICTED: serine/thre ( 563) 788 78.0 1.3e-13 XP_016862705 (OMIM: 609779) PREDICTED: serine/thre ( 563) 788 78.0 1.3e-13 XP_016862701 (OMIM: 609779) PREDICTED: serine/thre ( 609) 788 78.1 1.3e-13 NP_835464 (OMIM: 609799,613824,615415) serine/thre ( 692) 752 75.3 9.8e-13 XP_016879988 (OMIM: 609799,613824,615415) PREDICTE ( 705) 730 73.6 3.3e-12 NP_149107 (OMIM: 609798,614262,617022,617025) seri ( 979) 712 72.5 1e-11 NP_001316166 (OMIM: 609798,614262,617022,617025) s ( 991) 712 72.5 1e-11 XP_011522942 (OMIM: 609799,613824,615415) PREDICTE ( 716) 700 71.3 1.7e-11 XP_016879990 (OMIM: 609799,613824,615415) PREDICTE ( 484) 678 69.3 4.6e-11 XP_011522940 (OMIM: 609799,613824,615415) PREDICTE ( 729) 678 69.6 5.6e-11 XP_016862711 (OMIM: 609779) PREDICTED: serine/thre ( 512) 651 67.2 2.1e-10 XP_016862700 (OMIM: 609779) PREDICTED: serine/thre ( 641) 653 67.5 2.1e-10 XP_016862710 (OMIM: 609779) PREDICTED: serine/thre ( 524) 651 67.2 2.1e-10 XP_016862709 (OMIM: 609779) PREDICTED: serine/thre ( 526) 651 67.2 2.1e-10 XP_016862695 (OMIM: 609779) PREDICTED: serine/thre ( 687) 653 67.6 2.1e-10 XP_016862694 (OMIM: 609779) PREDICTED: serine/thre ( 687) 653 67.6 2.1e-10 >>XP_006713373 (OMIM: 601959) PREDICTED: serine/threonin (795 aa) initn: 5220 init1: 5220 opt: 5220 Z-score: 2243.5 bits: 426.0 E(85289): 3.2e-118 Smith-Waterman score: 5220; 100.0% identity (100.0% similar) in 795 aa overlap (1-795:1-795) 10 20 30 40 50 60 pF1KE3 MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 MLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 SNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 TISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 PENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQDQVAGECIIEKQGRIHPDLQPHNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQDQVAGECIIEKQGRIHPDLQPHNS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 GSEPSLSRQRRQKRREQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GSEPSLSRQRRQKRREQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 ENQRRVVTGSVSSSRSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ENQRRVVTGSVSSSRSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 KPQEEDQPLPARRLSSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KPQEEDQPLPARRLSSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEIN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 ALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 AIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYS 730 740 750 760 770 780 790 pF1KE3 VKARQLKFFEENMNF ::::::::::::::: XP_006 VKARQLKFFEENMNF 790 >>XP_016862575 (OMIM: 601959) PREDICTED: serine/threonin (824 aa) initn: 5025 init1: 5025 opt: 5025 Z-score: 2160.7 bits: 410.7 E(85289): 1.3e-113 Smith-Waterman score: 5025; 99.9% identity (100.0% similar) in 766 aa overlap (1-766:1-766) 10 20 30 40 50 60 pF1KE3 MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 MLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 SNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 TISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 PENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQDQVAGECIIEKQGRIHPDLQPHNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQDQVAGECIIEKQGRIHPDLQPHNS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 GSEPSLSRQRRQKRREQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSEPSLSRQRRQKRREQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 ENQRRVVTGSVSSSRSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENQRRVVTGSVSSSRSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 KPQEEDQPLPARRLSSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPQEEDQPLPARRLSSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEIN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 ALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 AIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYS :::::::::::::::::::::::::::::::::::::::::::::. XP_016 AIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDRELLPVFTPLMHSLPSG 730 740 750 760 770 780 790 pF1KE3 VKARQLKFFEENMNF XP_016 LFAIFTLQSPELSLCLQHGDNAQVRKTDSQKDQVPVVLLHHFPV 790 800 810 820 >>XP_011532342 (OMIM: 601959) PREDICTED: serine/threonin (671 aa) initn: 3015 init1: 3015 opt: 3047 Z-score: 1322.8 bits: 255.4 E(85289): 6.1e-67 Smith-Waterman score: 4007; 93.1% identity (93.1% similar) in 668 aa overlap (1-622:1-668) 10 20 30 40 50 60 pF1KE3 MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 MLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 SNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 TISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQ 370 380 390 400 410 420 430 440 450 pF1KE3 PENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQ------------------------ :::::::::::::::::::::::::::::::::::: XP_011 PENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQSLALSPKLECSGTILAHSNLRLLG 430 440 450 460 470 480 460 470 480 490 pF1KE3 ----------------------DQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKR :::::::::::::::::::::::::::::::::::::: XP_011 SSDSPASASRVAGITGVCHHAQDQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKR 490 500 510 520 530 540 500 510 520 530 540 550 pF1KE3 REQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 REQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSS 550 560 570 580 590 600 560 570 580 590 600 610 pF1KE3 RSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRL 610 620 630 640 650 660 620 630 640 650 660 670 pF1KE3 SSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDS :::::::: XP_011 SSDCSVTQVIL 670 >>NP_003148 (OMIM: 601959) serine/threonine-protein kina (841 aa) initn: 3015 init1: 3015 opt: 3047 Z-score: 1321.9 bits: 255.5 E(85289): 6.8e-67 Smith-Waterman score: 5025; 94.4% identity (94.4% similar) in 827 aa overlap (1-781:1-827) 10 20 30 40 50 60 pF1KE3 MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 MLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 SNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 TISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQ 370 380 390 400 410 420 430 440 450 pF1KE3 PENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQ------------------------ :::::::::::::::::::::::::::::::::::: NP_003 PENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQSLALSPKLECSGTILAHSNLRLLG 430 440 450 460 470 480 460 470 480 490 pF1KE3 ----------------------DQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKR :::::::::::::::::::::::::::::::::::::: NP_003 SSDSPASASRVAGITGVCHHAQDQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKR 490 500 510 520 530 540 500 510 520 530 540 550 pF1KE3 REQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 REQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSS 550 560 570 580 590 600 560 570 580 590 600 610 pF1KE3 RSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRL 610 620 630 640 650 660 620 630 640 650 660 670 pF1KE3 SSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDS 670 680 690 700 710 720 680 690 700 710 720 730 pF1KE3 KESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVE 730 740 750 760 770 780 740 750 760 770 780 790 pF1KE3 VLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQLKFFEENMN ::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQLKFFEENMN 790 800 810 820 830 840 pF1KE3 F NP_003 F >>XP_011532341 (OMIM: 601959) PREDICTED: serine/threonin (842 aa) initn: 3015 init1: 3015 opt: 3047 Z-score: 1321.9 bits: 255.5 E(85289): 6.8e-67 Smith-Waterman score: 4922; 94.3% identity (94.3% similar) in 811 aa overlap (1-765:1-811) 10 20 30 40 50 60 pF1KE3 MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 MLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 SNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 TISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQ 370 380 390 400 410 420 430 440 450 pF1KE3 PENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQ------------------------ :::::::::::::::::::::::::::::::::::: XP_011 PENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQSLALSPKLECSGTILAHSNLRLLG 430 440 450 460 470 480 460 470 480 490 pF1KE3 ----------------------DQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKR :::::::::::::::::::::::::::::::::::::: XP_011 SSDSPASASRVAGITGVCHHAQDQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKR 490 500 510 520 530 540 500 510 520 530 540 550 pF1KE3 REQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 REQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSS 550 560 570 580 590 600 560 570 580 590 600 610 pF1KE3 RSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRL 610 620 630 640 650 660 620 630 640 650 660 670 pF1KE3 SSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDS 670 680 690 700 710 720 680 690 700 710 720 730 pF1KE3 KESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVE 730 740 750 760 770 780 740 750 760 770 780 790 pF1KE3 VLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQLKFFEENMN ::::::::::::::::::::::::::::::: XP_011 VLRTDVIRGLGVQLLEQVYDLLEEEDEFDRECPCLAPAPGHCRQPHKMNQELPLPPQLSG 790 800 810 820 830 840 pF1KE3 F XP_011 KV >>XP_016862574 (OMIM: 601959) PREDICTED: serine/threonin (870 aa) initn: 5018 init1: 3015 opt: 3047 Z-score: 1321.8 bits: 255.6 E(85289): 6.9e-67 Smith-Waterman score: 4923; 94.2% identity (94.3% similar) in 812 aa overlap (1-766:1-812) 10 20 30 40 50 60 pF1KE3 MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 MLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 SNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 TISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQ 370 380 390 400 410 420 430 440 450 pF1KE3 PENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQ------------------------ :::::::::::::::::::::::::::::::::::: XP_016 PENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQSLALSPKLECSGTILAHSNLRLLG 430 440 450 460 470 480 460 470 480 490 pF1KE3 ----------------------DQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKR :::::::::::::::::::::::::::::::::::::: XP_016 SSDSPASASRVAGITGVCHHAQDQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKR 490 500 510 520 530 540 500 510 520 530 540 550 pF1KE3 REQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 REQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSS 550 560 570 580 590 600 560 570 580 590 600 610 pF1KE3 RSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRL 610 620 630 640 650 660 620 630 640 650 660 670 pF1KE3 SSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDS 670 680 690 700 710 720 680 690 700 710 720 730 pF1KE3 KESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVE 730 740 750 760 770 780 740 750 760 770 780 790 pF1KE3 VLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQLKFFEENMN :::::::::::::::::::::::::::::::. XP_016 VLRTDVIRGLGVQLLEQVYDLLEEEDEFDRELLPVFTPLMHSLPSGLFAIFTLQSPELSL 790 800 810 820 830 840 pF1KE3 F XP_016 CLQHGDNAQVRKTDSQKDQVPVVLLHHFPV 850 860 870 >>NP_001180462 (OMIM: 601959) serine/threonine-protein k (752 aa) initn: 2421 init1: 2224 opt: 2256 Z-score: 987.0 bits: 193.4 E(85289): 3.1e-48 Smith-Waterman score: 4250; 83.7% identity (83.7% similar) in 827 aa overlap (1-781:1-738) 10 20 30 40 50 60 pF1KE3 MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL :::::::::::::::::::::::::::::::: NP_001 MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQY---------------------------- 10 20 30 70 80 90 100 110 120 pF1KE3 KHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQ NP_001 ------------------------------------------------------------ 130 140 150 160 170 180 pF1KE3 YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 -LHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE3 KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT 100 110 120 130 140 150 250 260 270 280 290 300 pF1KE3 MLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAE 160 170 180 190 200 210 310 320 330 340 350 360 pF1KE3 SNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELA 220 230 240 250 260 270 370 380 390 400 410 420 pF1KE3 TISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQ 280 290 300 310 320 330 430 440 450 pF1KE3 PENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQ------------------------ :::::::::::::::::::::::::::::::::::: NP_001 PENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQSLALSPKLECSGTILAHSNLRLLG 340 350 360 370 380 390 460 470 480 490 pF1KE3 ----------------------DQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKR :::::::::::::::::::::::::::::::::::::: NP_001 SSDSPASASRVAGITGVCHHAQDQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKR 400 410 420 430 440 450 500 510 520 530 540 550 pF1KE3 REQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 REQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSS 460 470 480 490 500 510 560 570 580 590 600 610 pF1KE3 RSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRL 520 530 540 550 560 570 620 630 640 650 660 670 pF1KE3 SSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDS 580 590 600 610 620 630 680 690 700 710 720 730 pF1KE3 KESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVE 640 650 660 670 680 690 740 750 760 770 780 790 pF1KE3 VLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQLKFFEENMN ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQLKFFEENMN 700 710 720 730 740 750 pF1KE3 F NP_001 F >>XP_011530306 (OMIM: 263520,604588) PREDICTED: serine/t (1214 aa) initn: 797 init1: 756 opt: 988 Z-score: 447.5 bits: 94.3 E(85289): 3.5e-18 Smith-Waterman score: 1000; 29.8% identity (61.3% similar) in 732 aa overlap (3-697:1-707) 10 20 30 40 50 60 pF1KE3 MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL . : :. .:.::.:.. ::: .::.:::::..:. ::.::. ...:. .:... XP_011 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANM 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 KHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQ :::::: :.::.: .: ::::: .::::::..... ::: :. :.:...::::: .::. XP_011 KHPNIVQYRESFEE-NGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALK 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN ..:...:::::.:.::.:::. . ...::.::::::.. ..: : ::::::.:::. : XP_011 HVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICEN 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE3 KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT :::: :::.::::: .::. ::::::.: .:..:: .:: :..::. :: .: :. XP_011 KPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQ 180 190 200 210 220 230 250 260 270 280 290 pF1KE3 MLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTS---KNNIKNGDSQSKPFATVVSG .... :..:::: :::.. .: ..: :: : :. : : :: : .:: XP_011 LFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFG-SQPIPAKRPASG 240 250 260 270 280 290 300 310 320 330 340 pF1KE3 EAESNHEVIHP-----QPLSSEGSQTYIMGEG-KCLSQEKP--RASGLLKSPASLKAHTC . : . : .: .. : : : : ..:: . . ..: . ...: XP_011 Q---NSISVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEK-RVNTG 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE3 KQDLSNTTELATISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEE .. . . : : ... : .:.. . . :.. : .: . :....:. XP_011 EERRKISEEAARKRRLEFIEKEKKQKDQIISLMKAEQMKR-----QEKERLERINRAREQ 360 370 380 390 400 410 420 430 440 450 460 pF1KE3 MLQDNTKSSAQPENLIPMWSSDIVTGEKN-------EPVKPLQPLIKEQKPKDQDQVAGE .. ..... : :. .: . . .. : . . ...:. .:.. . XP_011 GWRNVLSAGGSGEVKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKR 410 420 430 440 450 460 470 480 490 500 510 pF1KE3 CIIEKQGRIHPDLQPHNSGSEPSLSRQRR-QKRRE--QTEHRGEK--------RQVRRDL : :: :. : . . : . . .. :..:: :.. :.: ::.: . XP_011 ---EIYGRGLPERQKGQLAVERAKQVEEFLQRKREAMQNKARAEGHMVYLARLRQIRLQN 470 480 490 500 510 520 520 530 540 550 560 pF1KE3 FAF-QESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTG--SVSSSRSSEMSSSKDRPLS : :. .. . ... . ..::. .:. . . . ...:.. .. . .: . XP_011 FNERQQIKAKLRGEKKEANHSEGQEGSEEADMRRKKIESLKAHANARAAVLKEQLERKRK 530 540 550 560 570 580 570 580 590 600 610 620 pF1KE3 ARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARR-LSSDCSVTQERKQI .:. : .:.. ..: :.....: : :.: :... . : :::. :.. XP_011 EAYEREKKVWEEHLVAKG--VKSSDVS---PPLGQHETGGSPSKQQMRSVISVTSALKEV 590 600 610 620 630 630 640 650 660 670 680 pF1KE3 HCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLD----SKESCEDVPV ..:: ..: ... .. . .. . ... ....:: . .:.. :. XP_011 G------VDSSLTDTRETSEEMQKTNNAISSKREILRRLNENLKAQEDEKGKQNLSDTFE 640 650 660 670 680 690 690 700 710 720 730 740 pF1KE3 ANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRG : . : :.: . XP_011 INVHEDAKEHEKEKSVSSDRKKWEAGGQLVIPLDELTLDTSFSTTERHTVGEVIKLGPNG 700 710 720 730 740 750 >>NP_001186329 (OMIM: 263520,604588) serine/threonine-pr (1214 aa) initn: 797 init1: 756 opt: 988 Z-score: 447.5 bits: 94.3 E(85289): 3.5e-18 Smith-Waterman score: 1000; 29.8% identity (61.3% similar) in 732 aa overlap (3-697:1-707) 10 20 30 40 50 60 pF1KE3 MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL . : :. .:.::.:.. ::: .::.:::::..:. ::.::. ...:. .:... NP_001 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANM 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 KHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQ :::::: :.::.: .: ::::: .::::::..... ::: :. :.:...::::: .::. NP_001 KHPNIVQYRESFEE-NGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALK 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN ..:...:::::.:.::.:::. . ...::.::::::.. ..: : ::::::.:::. : NP_001 HVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICEN 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE3 KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT :::: :::.::::: .::. ::::::.: .:..:: .:: :..::. :: .: :. NP_001 KPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQ 180 190 200 210 220 230 250 260 270 280 290 pF1KE3 MLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTS---KNNIKNGDSQSKPFATVVSG .... :..:::: :::.. .: ..: :: : :. : : :: : .:: NP_001 LFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFG-SQPIPAKRPASG 240 250 260 270 280 290 300 310 320 330 340 pF1KE3 EAESNHEVIHP-----QPLSSEGSQTYIMGEG-KCLSQEKP--RASGLLKSPASLKAHTC . : . : .: .. : : : : ..:: . . ..: . ...: NP_001 Q---NSISVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEK-RVNTG 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE3 KQDLSNTTELATISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEE .. . . : : ... : .:.. . . :.. : .: . :....:. NP_001 EERRKISEEAARKRRLEFIEKEKKQKDQIISLMKAEQMKR-----QEKERLERINRAREQ 360 370 380 390 400 410 420 430 440 450 460 pF1KE3 MLQDNTKSSAQPENLIPMWSSDIVTGEKN-------EPVKPLQPLIKEQKPKDQDQVAGE .. ..... : :. .: . . .. : . . ...:. .:.. . NP_001 GWRNVLSAGGSGEVKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKR 410 420 430 440 450 460 470 480 490 500 510 pF1KE3 CIIEKQGRIHPDLQPHNSGSEPSLSRQRR-QKRRE--QTEHRGEK--------RQVRRDL : :: :. : . . : . . .. :..:: :.. :.: ::.: . NP_001 ---EIYGRGLPERQKGQLAVERAKQVEEFLQRKREAMQNKARAEGHMVYLARLRQIRLQN 470 480 490 500 510 520 520 530 540 550 560 pF1KE3 FAF-QESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTG--SVSSSRSSEMSSSKDRPLS : :. .. . ... . ..::. .:. . . . ...:.. .. . .: . NP_001 FNERQQIKAKLRGEKKEANHSEGQEGSEEADMRRKKIESLKAHANARAAVLKEQLERKRK 530 540 550 560 570 580 570 580 590 600 610 620 pF1KE3 ARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARR-LSSDCSVTQERKQI .:. : .:.. ..: :.....: : :.: :... . : :::. :.. NP_001 EAYEREKKVWEEHLVAKG--VKSSDVS---PPLGQHETGGSPSKQQMRSVISVTSALKEV 590 600 610 620 630 630 640 650 660 670 680 pF1KE3 HCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLD----SKESCEDVPV ..:: ..: ... .. . .. . ... ....:: . .:.. :. NP_001 G------VDSSLTDTRETSEEMQKTNNAISSKREILRRLNENLKAQEDEKGKQNLSDTFE 640 650 660 670 680 690 690 700 710 720 730 740 pF1KE3 ANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRG : . : :.: . NP_001 INVHEDAKEHEKEKSVSSDRKKWEAGGQLVIPLDELTLDTSFSTTERHTVGEVIKLGPNG 700 710 720 730 740 750 >>XP_011530307 (OMIM: 263520,604588) PREDICTED: serine/t (715 aa) initn: 834 init1: 756 opt: 979 Z-score: 445.7 bits: 93.2 E(85289): 4.3e-18 Smith-Waterman score: 1002; 29.5% identity (60.3% similar) in 760 aa overlap (3-746:1-713) 10 20 30 40 50 60 pF1KE3 MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL . : :. .:.::.:.. ::: .::.:::::..:. ::.::. ...:. .:... XP_011 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANM 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 KHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQ :::::: :.::.: .: ::::: .::::::..... ::: :. :.:...::::: .::. XP_011 KHPNIVQYRESFEE-NGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALK 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN ..:...:::::.:.::.:::. . ...::.::::::.. ..: : ::::::.:::. : XP_011 HVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICEN 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE3 KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT :::: :::.::::: .::. ::::::.: .:..:: .:: :..::. :: .: :. XP_011 KPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQ 180 190 200 210 220 230 250 260 270 280 290 pF1KE3 MLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTS---KNNIKNGDSQSKPFATVVSG .... :..:::: :::.. .: ..: :: : :. : : :: : .:: XP_011 LFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFG-SQPIPAKRPASG 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 EAESNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTT . .. :. : ... ... : : ...: . . :.. .:: . :: XP_011 Q--NSISVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHK--QAHQTPEKRVNTG 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE3 ELATISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKS : .:. :. : :. :.. . : : .... :.: :. ... XP_011 E----ERRKISEEAARKR---RLEFI-EKEKKQKDQIISLMKAEQMKRQEKERLERINRA 360 370 380 390 400 420 430 440 450 460 470 pF1KE3 SAQPENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQDQVAGECIIEKQGRIHPDLQP : : . . .: ..: :: :.. .. ... :. : ..: XP_011 REQG------WRNVLSAGGSGE-VKA--PFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQ 410 420 430 440 450 480 490 500 510 520 530 pF1KE3 HNSGSEPSLSRQRRQKRREQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKV--DVTS . .: . .. .:. . .:: :: : . . . .:. . :. . . XP_011 QR--AEDNEAKWKREIYGRGLPERGILPGVRPG-FPYGAAGHHHFPDADDIRKTLKRLKA 460 470 480 490 500 510 540 550 560 570 580 590 pF1KE3 TQKEAENQRRVVTGSVSSSRSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLS ..:.:. .:. :... :.... .: : . . ... . .. .. . : XP_011 VSKQANANRQ--KGQLAVERAKQVEEFLQRKREAMQNKARAEGHMGILQNLAAMYGGRPS 520 530 540 550 560 570 600 610 620 630 640 650 pF1KE3 VAGPGKPQEEDQPLPARRLSS-DCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKG . :::..... . :: . . .::.::. . : :......::. XP_011 SSRGGKPRNKEEEVYLARLRQIRLQNFNERQQIKAKLRGE---------KKEANHSEGQE 580 590 600 610 620 660 670 680 690 700 710 pF1KE3 QTNEINALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEE---AE ..: . . :..: .. .. .: : . .:.:: ... . :: :: :. XP_011 GSEEADM------RRKKIESLKAHANARAA--VLKEQLERKRKEAYEREKKVWEEHLVAK 630 640 650 660 670 720 730 740 750 760 pF1KE3 EIHFKELPSAI-------MPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDR .. ... . :.....: .. : :.... .:: XP_011 GVKSSDVSPPLGQHETGGSPSKQQMRSVISV--TSALKEVGVDC 680 690 700 710 770 780 790 pF1KE3 EVRLREHMGEKYTTYSVKARQLKFFEENMNF 795 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 16:11:33 2016 done: Mon Nov 7 16:11:35 2016 Total Scan time: 11.810 Total Display time: 0.230 Function used was FASTA [36.3.4 Apr, 2011]