FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9428, 518 aa 1>>>pF1KB9428 518 - 518 aa - 518 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.4588+/-0.000462; mu= -13.9519+/- 0.028 mean_var=758.0753+/-172.312, 0's: 0 Z-trim(121.7): 402 B-trim: 2324 in 1/60 Lambda= 0.046582 statistics sampled from 38029 (38698) to 38029 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.771), E-opt: 0.2 (0.454), width: 16 Scan time: 11.930 The best scores are: opt bits E(85289) NP_006862 (OMIM: 605817) receptor-interacting seri ( 518) 3572 255.8 2.3e-67 NP_065690 (OMIM: 263650,605706) receptor-interacti ( 784) 526 51.3 1.2e-05 NP_003812 (OMIM: 603455) receptor-interacting seri ( 540) 516 50.4 1.6e-05 NP_848605 (OMIM: 608774) ankyrin repeat and protei ( 765) 479 48.1 0.00011 XP_011541039 (OMIM: 608774) PREDICTED: ankyrin rep ( 766) 479 48.1 0.00011 XP_016872964 (OMIM: 608774) PREDICTED: ankyrin rep ( 775) 399 42.8 0.0046 XP_011541038 (OMIM: 608774) PREDICTED: ankyrin rep ( 776) 399 42.8 0.0046 >>NP_006862 (OMIM: 605817) receptor-interacting serine/t (518 aa) initn: 3572 init1: 3572 opt: 3572 Z-score: 1330.3 bits: 255.8 E(85289): 2.3e-67 Smith-Waterman score: 3572; 100.0% identity (100.0% similar) in 518 aa overlap (1-518:1-518) 10 20 30 40 50 60 pF1KB9 MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISRE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 VKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 LKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 GTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 GTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 SLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVST 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 VKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 VPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 PRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 PRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLA 430 440 450 460 470 480 490 500 510 pF1KB9 PSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK :::::::::::::::::::::::::::::::::::::: NP_006 PSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK 490 500 510 >>NP_065690 (OMIM: 263650,605706) receptor-interacting s (784 aa) initn: 441 init1: 251 opt: 526 Z-score: 222.1 bits: 51.3 E(85289): 1.2e-05 Smith-Waterman score: 531; 30.8% identity (59.1% similar) in 413 aa overlap (20-416:21-402) 10 20 30 40 50 pF1KB9 MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAIS- :. . : ::.:::: :....: .: .:.: : .. NP_065 MEGDGGTPWALALLRTFDAGEFTGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDD 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 -------REVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCP .:.: : ...: . :. ..: .:: ..::.::: :: :. : NP_065 RERMELLEEAKKMEMAKFRYILPVYGIC------REPV-GLVMEYMETGSLEKLLASE-P 70 80 90 100 110 120 130 140 150 160 170 pF1KB9 RPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQ :: : :...:...:: .:: . : ::: ::::.:.::: . :::..::::. .: :. NP_065 LPWDLRFRIIHETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSH 120 130 140 150 160 170 180 190 200 210 220 pF1KB9 SGTGSGEPG--GTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLV : : . : ::..:: :: . . .: .: :::::.:..:.::. .. . : ... NP_065 SHDLSMD-GLFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKK-PFADEKNIL 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB9 YEAV-CNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQ . : . .:: : . .: :. . : .::: ::...:. ::.::: .:... . NP_065 HIMVKVVKGHRPELPPVCRARPR--ACSHLIRLMQRCWQGDPRVRPTFQEITSETEDLCE 240 250 260 270 280 290 300 310 320 330 340 pF1KB9 MVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEW ..... :..:. . : .: ..:. . :: .:: NP_065 KPDDEVKE---TAHDLDVKSPPEPRSEVVPAR---------LKRASAPTFD-NDYSLSEL 290 300 310 320 330 350 360 370 380 390 400 pF1KB9 LNKLNLEEPPSSVPKKCPSLTKRSRAQEE-QVPQAWT----AGTSSDSMAQPPQTPETST :..:. :.: . . . ::.. : ..:.. . .:.:: . : . . . NP_065 LSQLD-----SGVSQAVEGPEELSRSSSESKLPSSGSGKRLSGVSSVDSAFSSRGSLSLS 340 350 360 370 380 390 410 420 430 440 450 460 pF1KB9 FRNQMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDN :. . :: .. :: NP_065 FERE-PSTSDLGTTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAG 400 410 420 430 440 >>NP_003812 (OMIM: 603455) receptor-interacting serine/t (540 aa) initn: 477 init1: 226 opt: 516 Z-score: 220.2 bits: 50.4 E(85289): 1.6e-05 Smith-Waterman score: 516; 32.8% identity (63.4% similar) in 320 aa overlap (14-311:11-320) 10 20 30 40 50 pF1KB9 MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVK-------IVN : . ..: . . ...:. ::: :.: : .:::: ... NP_003 MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLD 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 S--KAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKP-ALVTKFMENGSLSGLLQSQC : : . ::.. . . ..: . :. . .:. ..::..: ::::. ::. . NP_003 SERKDVLREAEILHKARFSYILPILGICN------EPEFLGIVTEYMPNGSLNELLHRKT 60 70 80 90 100 110 120 130 140 150 160 pF1KB9 PRP---WPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQ : ::: :.:.:..::. :::...: :::.::: .:.::: :.:::.:::::: .. NP_003 EYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWR 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB9 --GGSQSGTGSGEP-GGTLGYLAPELFVNVNR-KASTASDVYSFGILMWAVLAGRE-VEL . ::: .... : :::. :. :: . .. .:: :.::.... : ::. .. : NP_003 MMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFED 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB9 PTEPSLVYEAVCNRQNRPSLAE--LPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECL :.: .. .: .. .:: . : :: . : . :.. :...: .:::: .:: NP_003 VTNPLQIMYSV-SQGHRPVINEESLPY---DIPHRARMISLIESGWAQNPDERPSFLKCL 240 250 260 270 280 290 300 310 320 330 pF1KB9 PKTDEVFQMVENN--MNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQH . . :.. :. ..:... : :... :. NP_003 IELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCG 290 300 310 320 330 340 340 350 360 370 380 390 pF1KB9 SRNDVMVSEWLNKLNLEEPPSSVPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQT NP_003 SSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFC 350 360 370 380 390 400 >>NP_848605 (OMIM: 608774) ankyrin repeat and protein ki (765 aa) initn: 487 init1: 181 opt: 479 Z-score: 205.2 bits: 48.1 E(85289): 0.00011 Smith-Waterman score: 479; 31.2% identity (62.5% similar) in 288 aa overlap (14-292:14-294) 10 20 30 40 50 pF1KB9 MSCVKLWPSGAPAPLVSIEELE-NQELVGKGGFGTVFRAQHRKWGYDVAVKI---VNSKA :. . ...: . .::..:::. ::.:.::.: . :.: . : NP_848 MAADPTELRLGSLPVFTRDDFEGDWRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPPDA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 ISREVKAMASLDNEFV-LRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLL--QSQCPRP : .:. . .. .... .. . ..: ..: .:: :::: .: .: : NP_848 ASSDVNYLIEEAAKMKKIKFQHIVSIYGVCKQPL-GIVMEFMANGSLEKVLSTHSLC--- 70 80 90 100 110 120 130 140 150 160 170 pF1KB9 WPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTF--QGGSQ : : :...:. :.: .::. .: ::: ::::.:.::: ..:::..::::: . :. . NP_848 WKLRFRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRM 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB9 SGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYE . . : :.:. ::.:.. :. . :::::.:..: .:. .. . .. NP_848 QYIERSALRGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKKPYSGFNMMMIII 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB9 AVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVE : . :::: . . : . . .::. ::...:: :: : . .:: ...... NP_848 RVAAGM-RPSLQPVSDQWPSEA--QQMVDLMKRCWDQDPKKRPCFLDITIETDILLSLLQ 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 NNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNK . NP_848 SRVAVPESKALARKVSCKLSLRQPGEVNEDISQELMDSDSGNYLKRALQLSDRKNLVPRD 300 310 320 330 340 350 >>XP_011541039 (OMIM: 608774) PREDICTED: ankyrin repeat (766 aa) initn: 487 init1: 181 opt: 479 Z-score: 205.1 bits: 48.1 E(85289): 0.00011 Smith-Waterman score: 479; 31.2% identity (62.5% similar) in 288 aa overlap (14-292:14-294) 10 20 30 40 50 pF1KB9 MSCVKLWPSGAPAPLVSIEELE-NQELVGKGGFGTVFRAQHRKWGYDVAVKI---VNSKA :. . ...: . .::..:::. ::.:.::.: . :.: . : XP_011 MAADPTELRLGSLPVFTRDDFEGDWRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPPDA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 ISREVKAMASLDNEFV-LRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLL--QSQCPRP : .:. . .. .... .. . ..: ..: .:: :::: .: .: : XP_011 ASSDVNYLIEEAAKMKKIKFQHIVSIYGVCKQPL-GIVMEFMANGSLEKVLSTHSLC--- 70 80 90 100 110 120 130 140 150 160 170 pF1KB9 WPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTF--QGGSQ : : :...:. :.: .::. .: ::: ::::.:.::: ..:::..::::: . :. . XP_011 WKLRFRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRM 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB9 SGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYE . . : :.:. ::.:.. :. . :::::.:..: .:. .. . .. XP_011 QYIERSALRGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKKPYSGFNMMMIII 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB9 AVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVE : . :::: . . : . . .::. ::...:: :: : . .:: ...... XP_011 RVAAGM-RPSLQPVSDQWPSEA--QQMVDLMKRCWDQDPKKRPCFLDITIETDILLSLLQ 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 NNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNK . XP_011 SRVAVPESKALARKVSCKLSLRQPGEVNEDISQELMDSADSGNYLKRALQLSDRKNLVPR 300 310 320 330 340 350 >>XP_016872964 (OMIM: 608774) PREDICTED: ankyrin repeat (775 aa) initn: 487 init1: 181 opt: 399 Z-score: 176.0 bits: 42.8 E(85289): 0.0046 Smith-Waterman score: 469; 30.6% identity (61.6% similar) in 297 aa overlap (14-292:14-304) 10 20 30 40 50 pF1KB9 MSCVKLWPSGAPAPLVSIEELE-NQELVGKGGFGTVFRAQHRKWGYDVAVKI---VNSKA :. . ...: . .::..:::. ::.:.::.: . :.: . : XP_016 MAADPTELRLGSLPVFTRDDFEGDWRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPPDA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 ISREVKAMASLDNEFV-LRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLL--QSQCPRP : .:. . .. .... .. . ..: ..: .:: :::: .: .: : XP_016 ASSDVNYLIEEAAKMKKIKFQHIVSIYGVCKQPL-GIVMEFMANGSLEKVLSTHSLC--- 70 80 90 100 110 120 130 140 150 160 170 pF1KB9 WPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTF--QGGSQ : : :...:. :.: .::. .: ::: ::::.:.::: ..:::..::::: . :. . XP_016 WKLRFRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRM 120 130 140 150 160 170 180 190 200 210 220 pF1KB9 SGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGRE------VELPTE . . : :.:. ::.:.. :. . :::::.:..: .:. .. .: . XP_016 QYIERSALRGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKKPYSELTSQLKER 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB9 PSLVYEAVCNRQN---RPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPK .. . . : :::: . . : . . .::. ::...:: :: : . . XP_016 KGFNMMMIIIRVAAGMRPSLQPVSDQWPSEA--QQMVDLMKRCWDQDPKKRPCFLDITIE 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB9 TDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRND :: ....... XP_016 TDILLSLLQSRVAVPESKALARKVSCKLSLRQPGEVNEDISQELMDSDSGNYLKRALQLS 300 310 320 330 340 350 >>XP_011541038 (OMIM: 608774) PREDICTED: ankyrin repeat (776 aa) initn: 487 init1: 181 opt: 399 Z-score: 176.0 bits: 42.8 E(85289): 0.0046 Smith-Waterman score: 469; 30.6% identity (61.6% similar) in 297 aa overlap (14-292:14-304) 10 20 30 40 50 pF1KB9 MSCVKLWPSGAPAPLVSIEELE-NQELVGKGGFGTVFRAQHRKWGYDVAVKI---VNSKA :. . ...: . .::..:::. ::.:.::.: . :.: . : XP_011 MAADPTELRLGSLPVFTRDDFEGDWRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPPDA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 ISREVKAMASLDNEFV-LRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLL--QSQCPRP : .:. . .. .... .. . ..: ..: .:: :::: .: .: : XP_011 ASSDVNYLIEEAAKMKKIKFQHIVSIYGVCKQPL-GIVMEFMANGSLEKVLSTHSLC--- 70 80 90 100 110 120 130 140 150 160 170 pF1KB9 WPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTF--QGGSQ : : :...:. :.: .::. .: ::: ::::.:.::: ..:::..::::: . :. . XP_011 WKLRFRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRM 120 130 140 150 160 170 180 190 200 210 220 pF1KB9 SGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGRE------VELPTE . . : :.:. ::.:.. :. . :::::.:..: .:. .. .: . XP_011 QYIERSALRGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKKPYSELTSQLKER 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB9 PSLVYEAVCNRQN---RPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPK .. . . : :::: . . : . . .::. ::...:: :: : . . XP_011 KGFNMMMIIIRVAAGMRPSLQPVSDQWPSEA--QQMVDLMKRCWDQDPKKRPCFLDITIE 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB9 TDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRND :: ....... XP_011 TDILLSLLQSRVAVPESKALARKVSCKLSLRQPGEVNEDISQELMDSADSGNYLKRALQL 300 310 320 330 340 350 518 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 16:05:03 2016 done: Mon Nov 7 16:05:05 2016 Total Scan time: 11.930 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]