FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1995, 575 aa 1>>>pF1KE1995 575 - 575 aa - 575 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.0002+/-0.000349; mu= 4.3612+/- 0.022 mean_var=270.0362+/-56.571, 0's: 0 Z-trim(123.7): 40 B-trim: 808 in 1/57 Lambda= 0.078048 statistics sampled from 43941 (43994) to 43941 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.804), E-opt: 0.2 (0.516), width: 16 Scan time: 11.860 The best scores are: opt bits E(85289) NP_005466 (OMIM: 133100,187950,254450,605093) SH2B ( 575) 3991 462.6 1.6e-129 XP_005253876 (OMIM: 133100,187950,254450,605093) P ( 576) 3979 461.2 4.1e-129 NP_001278353 (OMIM: 133100,187950,254450,605093) S ( 373) 2298 271.8 2.8e-72 XP_011536023 (OMIM: 133100,187950,254450,605093) P ( 374) 2286 270.4 7.3e-72 XP_005253875 (OMIM: 133100,187950,254450,605093) P ( 615) 2284 270.4 1.2e-71 XP_011536022 (OMIM: 133100,187950,254450,605093) P ( 616) 2272 269.0 3.1e-71 XP_011536021 (OMIM: 133100,187950,254450,605093) P ( 616) 2272 269.0 3.1e-71 XP_006719243 (OMIM: 133100,187950,254450,605093) P ( 309) 2129 252.7 1.3e-66 XP_016867170 (OMIM: 605300) PREDICTED: SH2B adapte ( 631) 585 79.1 4.8e-14 XP_016867169 (OMIM: 605300) PREDICTED: SH2B adapte ( 631) 585 79.1 4.8e-14 XP_005277036 (OMIM: 605300) PREDICTED: SH2B adapte ( 632) 585 79.1 4.8e-14 XP_005277034 (OMIM: 605300) PREDICTED: SH2B adapte ( 632) 585 79.1 4.8e-14 XP_011514042 (OMIM: 605300) PREDICTED: SH2B adapte ( 645) 585 79.1 4.8e-14 XP_005277033 (OMIM: 605300) PREDICTED: SH2B adapte ( 673) 585 79.1 5e-14 XP_005277032 (OMIM: 605300) PREDICTED: SH2B adapte ( 674) 585 79.1 5e-14 NP_066189 (OMIM: 605300) SH2B adapter protein 2 [H ( 675) 585 79.1 5e-14 NP_001139269 (OMIM: 608937) SH2B adapter protein 1 ( 683) 552 75.4 6.6e-13 XP_016878609 (OMIM: 608937) PREDICTED: SH2B adapte ( 391) 542 74.1 9.8e-13 XP_016878608 (OMIM: 608937) PREDICTED: SH2B adapte ( 420) 542 74.1 1e-12 XP_016878607 (OMIM: 608937) PREDICTED: SH2B adapte ( 420) 542 74.1 1e-12 XP_016878606 (OMIM: 608937) PREDICTED: SH2B adapte ( 688) 545 74.6 1.1e-12 XP_016878604 (OMIM: 608937) PREDICTED: SH2B adapte ( 756) 542 74.3 1.6e-12 XP_016878603 (OMIM: 608937) PREDICTED: SH2B adapte ( 756) 542 74.3 1.6e-12 XP_016878605 (OMIM: 608937) PREDICTED: SH2B adapte ( 756) 542 74.3 1.6e-12 NP_001295222 (OMIM: 608937) SH2B adapter protein 1 ( 756) 542 74.3 1.6e-12 NP_001139267 (OMIM: 608937) SH2B adapter protein 1 ( 756) 542 74.3 1.6e-12 NP_001295223 (OMIM: 608937) SH2B adapter protein 1 ( 335) 528 72.4 2.6e-12 NP_001139268 (OMIM: 608937) SH2B adapter protein 1 ( 671) 528 72.7 4.3e-12 NP_001139284 (OMIM: 608937) SH2B adapter protein 1 ( 671) 528 72.7 4.3e-12 NP_056318 (OMIM: 608937) SH2B adapter protein 1 is ( 671) 528 72.7 4.3e-12 >>NP_005466 (OMIM: 133100,187950,254450,605093) SH2B ada (575 aa) initn: 3991 init1: 3991 opt: 3991 Z-score: 2446.4 bits: 462.6 E(85289): 1.6e-129 Smith-Waterman score: 3991; 99.5% identity (99.8% similar) in 575 aa overlap (1-575:1-575) 10 20 30 40 50 60 pF1KE1 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGSPGEAAETPARPGLAK ::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::: NP_005 SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 KLLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF :.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 DPPKSSRPKLQAACSSIQEVRRCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMA ::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::: NP_005 DPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 ELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 CYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 CYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 RGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 RGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 LPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQ 490 500 510 520 530 540 550 560 570 pF1KE1 HLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL ::::::::::::::::::::::::::::::::::: NP_005 HLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL 550 560 570 >>XP_005253876 (OMIM: 133100,187950,254450,605093) PREDI (576 aa) initn: 3977 init1: 2135 opt: 3979 Z-score: 2439.1 bits: 461.2 E(85289): 4.1e-129 Smith-Waterman score: 3979; 99.3% identity (99.7% similar) in 576 aa overlap (1-575:1-576) 10 20 30 40 50 60 pF1KE1 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGSPGEAAETPARPGLAK ::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::: XP_005 SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 KLLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF :.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 DPPKSSRPKLQAACSSIQEVRRCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMA ::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::: XP_005 DPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMA 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 ELSECTGRG-LESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFL ::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ELSECTGRGRLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFL 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE1 SCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLT 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE1 ERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPF 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE1 SLPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SLPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSL 490 500 510 520 530 540 540 550 560 570 pF1KE1 QHLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL :::::::::::::::::::::::::::::::::::: XP_005 QHLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL 550 560 570 >>NP_001278353 (OMIM: 133100,187950,254450,605093) SH2B (373 aa) initn: 2288 init1: 2288 opt: 2298 Z-score: 1418.5 bits: 271.8 E(85289): 2.8e-72 Smith-Waterman score: 2298; 93.1% identity (94.5% similar) in 364 aa overlap (217-575:10-373) 190 200 210 220 230 240 pF1KE1 LAREPPPEALKEAVLRYSLADEASMDSGARWQR---GRLALRRAPGPDGP--DRVLELFD :.: : . :: :. : . .: NP_001 MGFPVLCRGWRRTWPGCASWLGAPPPQKPLLSPLLLNHR 10 20 30 250 260 270 280 290 300 pF1KE1 PPKSSRPKLQAACSSIQEVRRCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAE :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::: NP_001 SSKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAE 40 50 60 70 80 90 310 320 330 340 350 360 pF1KE1 LSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSC 100 110 120 130 140 150 370 380 390 400 410 420 pF1KE1 YPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTER 160 170 180 190 200 210 430 440 450 460 470 480 pF1KE1 GQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSL 220 230 240 250 260 270 490 500 510 520 530 540 pF1KE1 PHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQH 280 290 300 310 320 330 550 560 570 pF1KE1 LEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL :::::::::::::::::::::::::::::::::: NP_001 LEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL 340 350 360 370 >>XP_011536023 (OMIM: 133100,187950,254450,605093) PREDI (374 aa) initn: 2274 init1: 1856 opt: 2286 Z-score: 1411.2 bits: 270.4 E(85289): 7.3e-72 Smith-Waterman score: 2286; 92.9% identity (94.2% similar) in 365 aa overlap (217-575:10-374) 190 200 210 220 230 240 pF1KE1 LAREPPPEALKEAVLRYSLADEASMDSGARWQR---GRLALRRAPGPDGP--DRVLELFD :.: : . :: :. : . .: XP_011 MGFPVLCRGWRRTWPGCASWLGAPPPQKPLLSPLLLNHR 10 20 30 250 260 270 280 290 300 pF1KE1 PPKSSRPKLQAACSSIQEVRRCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAE :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::: XP_011 SSKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAE 40 50 60 70 80 90 310 320 330 340 350 360 pF1KE1 LSECTGRG-LESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLS :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSECTGRGRLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLS 100 110 120 130 140 150 370 380 390 400 410 420 pF1KE1 CYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTE 160 170 180 190 200 210 430 440 450 460 470 480 pF1KE1 RGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFS 220 230 240 250 260 270 490 500 510 520 530 540 pF1KE1 LPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQ 280 290 300 310 320 330 550 560 570 pF1KE1 HLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL ::::::::::::::::::::::::::::::::::: XP_011 HLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL 340 350 360 370 >>XP_005253875 (OMIM: 133100,187950,254450,605093) PREDI (615 aa) initn: 2284 init1: 2284 opt: 2284 Z-score: 1407.2 bits: 270.4 E(85289): 1.2e-71 Smith-Waterman score: 3842; 92.9% identity (93.2% similar) in 607 aa overlap (9-575:9-615) 10 20 30 40 50 60 pF1KE1 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGSPGEAAETPARPGLAK ::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::: XP_005 SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 KLLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF :.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF 190 200 210 220 230 240 250 260 pF1KE1 DPPK----------------------------------------SSRPKLQAACSSIQEV :::: :::::::::::::::: XP_005 DPPKWPEPELSRLRFRLKQGLSCAHVPTRCNLAGASGIGHPYHQSSRPKLQAACSSIQEV 250 260 270 280 290 300 270 280 290 300 310 320 pF1KE1 RRCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAELSECTGRGLESTEAEMHIP : :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAELSECTGRGLESTEAEMHIP 310 320 330 340 350 360 330 340 350 360 370 380 pF1KE1 SALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQL 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE1 QGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLHH 430 440 450 460 470 480 450 460 470 480 490 500 pF1KE1 FQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSLPHWDSESLPHWGSELGLPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSLPHWDSESLPHWGSELGLPH 490 500 510 520 530 540 510 520 530 540 550 560 pF1KE1 LSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDSS 550 560 570 580 590 600 570 pF1KE1 SRSHLRAIDNQYTPL ::::::::::::::: XP_005 SRSHLRAIDNQYTPL 610 >>XP_011536022 (OMIM: 133100,187950,254450,605093) PREDI (616 aa) initn: 3565 init1: 1856 opt: 2272 Z-score: 1399.9 bits: 269.0 E(85289): 3.1e-71 Smith-Waterman score: 3825; 92.8% identity (93.1% similar) in 607 aa overlap (10-575:10-616) 10 20 30 40 50 60 pF1KE1 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGSPGEAAETPARPGLAK ::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::: XP_011 SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 KLLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF :.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF 190 200 210 220 230 240 250 260 pF1KE1 DPPK----------------------------------------SSRPKLQAACSSIQEV :::: :::::::::::::::: XP_011 DPPKWPEPELSRLRFRLKQGLSCAHVPTRCNLAGASGIGHPYHQSSRPKLQAACSSIQEV 250 260 270 280 290 300 270 280 290 300 310 pF1KE1 RRCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAELSECTGRG-LESTEAEMHI : ::::::::::::::::::::::::::::::::::::::::::::::: :::::::::: XP_011 RWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAELSECTGRGRLESTEAEMHI 310 320 330 340 350 360 320 330 340 350 360 370 pF1KE1 PSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQ 370 380 390 400 410 420 380 390 400 410 420 430 pF1KE1 LQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLH 430 440 450 460 470 480 440 450 460 470 480 490 pF1KE1 HFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSLPHWDSESLPHWGSELGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSLPHWDSESLPHWGSELGLP 490 500 510 520 530 540 500 510 520 530 540 550 pF1KE1 HLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDS 550 560 570 580 590 600 560 570 pF1KE1 SSRSHLRAIDNQYTPL :::::::::::::::: XP_011 SSRSHLRAIDNQYTPL 610 >>XP_011536021 (OMIM: 133100,187950,254450,605093) PREDI (616 aa) initn: 3565 init1: 1856 opt: 2272 Z-score: 1399.9 bits: 269.0 E(85289): 3.1e-71 Smith-Waterman score: 3825; 92.8% identity (93.1% similar) in 607 aa overlap (10-575:10-616) 10 20 30 40 50 60 pF1KE1 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGSPGEAAETPARPGLAK ::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::: XP_011 SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 KLLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF :.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF 190 200 210 220 230 240 250 260 pF1KE1 DPPK----------------------------------------SSRPKLQAACSSIQEV :::: :::::::::::::::: XP_011 DPPKWPEPELSRLRFRLKQGLSCAHVPTRCNLAGASGIGHPYHQSSRPKLQAACSSIQEV 250 260 270 280 290 300 270 280 290 300 310 pF1KE1 RRCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAELSECTGRG-LESTEAEMHI : ::::::::::::::::::::::::::::::::::::::::::::::: :::::::::: XP_011 RWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAELSECTGRGRLESTEAEMHI 310 320 330 340 350 360 320 330 340 350 360 370 pF1KE1 PSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQ 370 380 390 400 410 420 380 390 400 410 420 430 pF1KE1 LQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLH 430 440 450 460 470 480 440 450 460 470 480 490 pF1KE1 HFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSLPHWDSESLPHWGSELGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSLPHWDSESLPHWGSELGLP 490 500 510 520 530 540 500 510 520 530 540 550 pF1KE1 HLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDS 550 560 570 580 590 600 560 570 pF1KE1 SSRSHLRAIDNQYTPL :::::::::::::::: XP_011 SSRSHLRAIDNQYTPL 610 >>XP_006719243 (OMIM: 133100,187950,254450,605093) PREDI (309 aa) initn: 2127 init1: 1856 opt: 2129 Z-score: 1316.7 bits: 252.7 E(85289): 1.3e-66 Smith-Waterman score: 2129; 99.7% identity (99.7% similar) in 309 aa overlap (268-575:1-309) 240 250 260 270 280 290 pF1KE1 ELFDPPKSSRPKLQAACSSIQEVRRCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNS :::::::::::::::::::::::::::::: XP_006 MPDNLYTFVLKVKDRTDIIFEVGDEQQLNS 10 20 30 300 310 320 330 340 350 pF1KE1 WMAELSECTGRG-LESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTD :::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WMAELSECTGRGRLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTD 40 50 60 70 80 90 360 370 380 390 400 410 pF1KE1 HFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRL 100 110 120 130 140 150 420 430 440 450 460 470 pF1KE1 SLTERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SLTERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVL 160 170 180 190 200 210 480 490 500 510 520 530 pF1KE1 FPFSLPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FPFSLPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELA 220 230 240 250 260 270 540 550 560 570 pF1KE1 NSLQHLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL ::::::::::::::::::::::::::::::::::::::: XP_006 NSLQHLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL 280 290 300 >>XP_016867170 (OMIM: 605300) PREDICTED: SH2B adapter pr (631 aa) initn: 824 init1: 504 opt: 585 Z-score: 373.2 bits: 79.1 E(85289): 4.8e-14 Smith-Waterman score: 894; 35.8% identity (54.5% similar) in 628 aa overlap (26-573:23-629) 10 20 30 40 50 pF1KE1 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQH-APLR : .:::::: ::: ..:... : :..: . .: XP_016 MNGAGPGPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDA 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 AELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEA-SPEPGPGPAAPGLP-- . : .:. : : .::: . : : :: ..::: :: . : . : XP_016 GASFSRHFAANFLDVFGEEVRRVLVAG----PTTRGAAVSAEAMEPELADTSALKAAPYG 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 KARSSEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGSPGEAAETPARP ..::::... . : :::.. : : :.: . :: :.: XP_016 HSRSSEDVSTHAATKARVRKGF--SLRNMSLCVVDGVRDMWHRRASPEPDAAAAPRTAEP 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 --GLAKKL-LPWSLAREPP-PEALKEAVLRYSLADEASMDSG--ARWQRGRLALRRAPGP ...: : .:: . . .:..::. .::.:. :: :.::. :: :::: . XP_016 RDKWTRRLRLSRTLAAKVELVDIQREGALRFMVADDAAAGSGGSAQWQKCRLLLRRAVAE 180 190 200 210 220 230 240 250 260 270 280 pF1KE1 DGPDRV-LELFDPPKSSRPKLQAACSSIQEVRRCTRLEMPDNLYTFVLKVKDRTDIIFEV . : ::.: :::.::::.. :.: ::: ::::.. ::::::.. .. :.:. XP_016 E---RFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILET 240 250 260 270 280 290 300 pF1KE1 GDEQQLNSWMAELSECT------------------------------------------- : : .::.:... :. XP_016 IDSLQKHSWVADIQGCVDPGDSEEDTELSCTRGGCLASRVASCSCELLTDVDLPRPPETT 290 300 310 320 330 340 310 320 330 340 350 pF1KE1 ----------GRGLEST-EAEMHIPSALEPSTSSSPRGS-TDSLNQGASPGGLLDPACQK .:: ... :. .:.: .: :: :: .:: : : . :. :: . XP_016 AVGAVVTAPHSRGRDAVRESLIHVPLETFLQTLESPGGSGSDSNNTGEQ-GAETDPEAEP 350 360 370 380 390 400 360 370 380 390 400 410 pF1KE1 TDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHL . :: :::::: .::::::::: :: ::.:..:::::: ::::::::::: :::: XP_016 -ELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHL 410 420 430 440 450 460 420 430 440 450 460 470 pF1KE1 RLSLTERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNT ::::. .:::.:::: : ::.:::.::. ::::: :.. :. : ::: . . :: : XP_016 RLSLNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQDPPPEPGPT 470 480 490 500 510 520 480 490 500 510 520 pF1KE1 V-LFPFSLPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSS------------- : : :.. :. : : ....:: . :: : :: XP_016 PPAAPASPACWSDSPGQHYFSSL-----AAAACPPA-SPSDAAGASSSSASSSSAASGPA 530 540 550 560 570 580 530 540 550 560 570 pF1KE1 PPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL ::. . . : . .:: ..: : : : . : .. .. ::..:::. XP_016 PPRPVEGQL-SARSRSNSAERLL-EAV--AATAAEEPPEAAPGRARAVENQYSFY 590 600 610 620 630 >>XP_016867169 (OMIM: 605300) PREDICTED: SH2B adapter pr (631 aa) initn: 824 init1: 504 opt: 585 Z-score: 373.2 bits: 79.1 E(85289): 4.8e-14 Smith-Waterman score: 894; 35.8% identity (54.5% similar) in 628 aa overlap (26-573:23-629) 10 20 30 40 50 pF1KE1 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQH-APLR : .:::::: ::: ..:... : :..: . .: XP_016 MNGAGPGPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDA 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 AELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEA-SPEPGPGPAAPGLP-- . : .:. : : .::: . : : :: ..::: :: . : . : XP_016 GASFSRHFAANFLDVFGEEVRRVLVAG----PTTRGAAVSAEAMEPELADTSALKAAPYG 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 KARSSEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGSPGEAAETPARP ..::::... . : :::.. : : :.: . :: :.: XP_016 HSRSSEDVSTHAATKARVRKGF--SLRNMSLCVVDGVRDMWHRRASPEPDAAAAPRTAEP 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 --GLAKKL-LPWSLAREPP-PEALKEAVLRYSLADEASMDSG--ARWQRGRLALRRAPGP ...: : .:: . . .:..::. .::.:. :: :.::. :: :::: . XP_016 RDKWTRRLRLSRTLAAKVELVDIQREGALRFMVADDAAAGSGGSAQWQKCRLLLRRAVAE 180 190 200 210 220 230 240 250 260 270 280 pF1KE1 DGPDRV-LELFDPPKSSRPKLQAACSSIQEVRRCTRLEMPDNLYTFVLKVKDRTDIIFEV . : ::.: :::.::::.. :.: ::: ::::.. ::::::.. .. :.:. XP_016 E---RFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILET 240 250 260 270 280 290 300 pF1KE1 GDEQQLNSWMAELSECT------------------------------------------- : : .::.:... :. XP_016 IDSLQKHSWVADIQGCVDPGDSEEDTELSCTRGGCLASRVASCSCELLTDVDLPRPPETT 290 300 310 320 330 340 310 320 330 340 350 pF1KE1 ----------GRGLEST-EAEMHIPSALEPSTSSSPRGS-TDSLNQGASPGGLLDPACQK .:: ... :. .:.: .: :: :: .:: : : . :. :: . XP_016 AVGAVVTAPHSRGRDAVRESLIHVPLETFLQTLESPGGSGSDSNNTGEQ-GAETDPEAEP 350 360 370 380 390 400 360 370 380 390 400 410 pF1KE1 TDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHL . :: :::::: .::::::::: :: ::.:..:::::: ::::::::::: :::: XP_016 -ELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHL 410 420 430 440 450 460 420 430 440 450 460 470 pF1KE1 RLSLTERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNT ::::. .:::.:::: : ::.:::.::. ::::: :.. :. : ::: . . :: : XP_016 RLSLNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQDPPPEPGPT 470 480 490 500 510 520 480 490 500 510 520 pF1KE1 V-LFPFSLPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSS------------- : : :.. :. : : ....:: . :: : :: XP_016 PPAAPASPACWSDSPGQHYFSSL-----AAAACPPA-SPSDAAGASSSSASSSSAASGPA 530 540 550 560 570 580 530 540 550 560 570 pF1KE1 PPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL ::. . . : . .:: ..: : : : . : .. .. ::..:::. XP_016 PPRPVEGQL-SARSRSNSAERLL-EAV--AATAAEEPPEAAPGRARAVENQYSFY 590 600 610 620 630 575 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 16:00:18 2016 done: Mon Nov 7 16:00:20 2016 Total Scan time: 11.860 Total Display time: 0.120 Function used was FASTA [36.3.4 Apr, 2011]