FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1191, 824 aa 1>>>pF1KE1191 824 - 824 aa - 824 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.3471+/-0.000442; mu= -11.9244+/- 0.027 mean_var=380.3071+/-79.209, 0's: 0 Z-trim(121.6): 191 B-trim: 1618 in 1/57 Lambda= 0.065767 statistics sampled from 38244 (38451) to 38244 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.763), E-opt: 0.2 (0.451), width: 16 Scan time: 14.820 The best scores are: opt bits E(85289) NP_002509 (OMIM: 603347) neuronal PAS domain-conta ( 824) 5537 540.0 1.6e-152 XP_005264010 (OMIM: 603347) PREDICTED: neuronal PA ( 889) 5537 540.0 1.7e-152 XP_005264016 (OMIM: 603347) PREDICTED: neuronal PA ( 835) 5130 501.4 7e-141 XP_016859704 (OMIM: 603347) PREDICTED: neuronal PA ( 838) 5128 501.2 8e-141 XP_011509544 (OMIM: 603347) PREDICTED: neuronal PA ( 794) 4762 466.4 2.2e-130 XP_005264018 (OMIM: 603347) PREDICTED: neuronal PA ( 700) 4740 464.3 8.3e-130 XP_016859703 (OMIM: 603347) PREDICTED: neuronal PA ( 843) 4127 406.2 3.1e-112 XP_016859705 (OMIM: 603347) PREDICTED: neuronal PA ( 789) 4085 402.2 4.7e-111 XP_011509545 (OMIM: 603347) PREDICTED: neuronal PA ( 637) 3656 361.4 7e-99 XP_005264017 (OMIM: 603347) PREDICTED: neuronal PA ( 786) 3502 346.9 2.1e-94 XP_016859706 (OMIM: 603347) PREDICTED: neuronal PA ( 732) 3095 308.2 8.3e-83 XP_011532713 (OMIM: 601851) PREDICTED: circadian l ( 846) 2567 258.2 1.1e-67 XP_011532712 (OMIM: 601851) PREDICTED: circadian l ( 846) 2567 258.2 1.1e-67 XP_011532711 (OMIM: 601851) PREDICTED: circadian l ( 846) 2567 258.2 1.1e-67 NP_004889 (OMIM: 601851) circadian locomoter outpu ( 846) 2567 258.2 1.1e-67 XP_005265844 (OMIM: 601851) PREDICTED: circadian l ( 846) 2567 258.2 1.1e-67 NP_001254772 (OMIM: 601851) circadian locomoter ou ( 846) 2567 258.2 1.1e-67 XP_016864343 (OMIM: 601851) PREDICTED: circadian l ( 846) 2567 258.2 1.1e-67 XP_016864344 (OMIM: 601851) PREDICTED: circadian l ( 787) 2384 240.8 1.8e-62 NP_001272965 (OMIM: 126110) aryl hydrocarbon recep ( 787) 342 47.1 0.00038 XP_011507848 (OMIM: 126110) PREDICTED: aryl hydroc ( 757) 330 45.9 0.00081 XP_016856779 (OMIM: 126110) PREDICTED: aryl hydroc ( 765) 330 45.9 0.00081 XP_011507847 (OMIM: 126110) PREDICTED: aryl hydroc ( 773) 330 45.9 0.00082 NP_848514 (OMIM: 126110) aryl hydrocarbon receptor ( 774) 330 45.9 0.00082 XP_005245211 (OMIM: 126110) PREDICTED: aryl hydroc ( 780) 330 45.9 0.00083 XP_011507846 (OMIM: 126110) PREDICTED: aryl hydroc ( 787) 330 45.9 0.00083 XP_011507844 (OMIM: 126110) PREDICTED: aryl hydroc ( 788) 330 45.9 0.00083 XP_011507845 (OMIM: 126110) PREDICTED: aryl hydroc ( 788) 330 45.9 0.00083 NP_001659 (OMIM: 126110) aryl hydrocarbon receptor ( 789) 330 45.9 0.00083 NP_001272964 (OMIM: 126110) aryl hydrocarbon recep ( 775) 329 45.8 0.00088 XP_016856778 (OMIM: 126110) PREDICTED: aryl hydroc ( 775) 329 45.8 0.00088 XP_005245210 (OMIM: 126110) PREDICTED: aryl hydroc ( 784) 329 45.8 0.00089 XP_016856780 (OMIM: 126110) PREDICTED: aryl hydroc ( 764) 328 45.7 0.00093 XP_011507849 (OMIM: 126110) PREDICTED: aryl hydroc ( 772) 328 45.7 0.00093 NP_001184254 (OMIM: 126110) aryl hydrocarbon recep ( 773) 328 45.7 0.00093 XP_016856777 (OMIM: 126110) PREDICTED: aryl hydroc ( 779) 328 45.7 0.00094 XP_005245208 (OMIM: 126110) PREDICTED: aryl hydroc ( 788) 328 45.7 0.00095 XP_016856785 (OMIM: 126110) PREDICTED: aryl hydroc ( 737) 324 45.3 0.0012 XP_016856781 (OMIM: 126110) PREDICTED: aryl hydroc ( 743) 324 45.3 0.0012 XP_005245214 (OMIM: 126110) PREDICTED: aryl hydroc ( 752) 324 45.3 0.0012 XP_016856784 (OMIM: 126110) PREDICTED: aryl hydroc ( 747) 323 45.2 0.0013 NP_851397 (OMIM: 603348) hypoxia-inducible factor ( 735) 322 45.1 0.0013 NP_001521 (OMIM: 603348) hypoxia-inducible factor ( 826) 322 45.2 0.0015 NP_001230013 (OMIM: 603348) hypoxia-inducible fact ( 850) 322 45.2 0.0015 XP_016856782 (OMIM: 126110) PREDICTED: aryl hydroc ( 727) 320 44.9 0.0015 XP_016856783 (OMIM: 126110) PREDICTED: aryl hydroc ( 751) 320 45.0 0.0015 NP_001025444 (OMIM: 602550) aryl hydrocarbon recep ( 582) 300 43.0 0.0047 XP_016873237 (OMIM: 602550) PREDICTED: aryl hydroc ( 582) 300 43.0 0.0047 XP_011518415 (OMIM: 602550) PREDICTED: aryl hydroc ( 582) 300 43.0 0.0047 XP_016873234 (OMIM: 602550) PREDICTED: aryl hydroc ( 587) 300 43.0 0.0047 >>NP_002509 (OMIM: 603347) neuronal PAS domain-containin (824 aa) initn: 5537 init1: 5537 opt: 5537 Z-score: 2859.1 bits: 540.0 E(85289): 1.6e-152 Smith-Waterman score: 5537; 99.9% identity (100.0% similar) in 824 aa overlap (1-824:1-824) 10 20 30 40 50 60 pF1KE1 MDEDEKDRAKRASRNKSEKKRRDQFNVLIKELSSMLPGNTRKMDKTTVLEKVIGFLQKHN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MDEDEKDRAKRASRNKSEKKRRDQFNVLIKELSSMLPGNTRKMDKTTVLEKVIGFLQKHN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 EVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGHL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 PSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLLRGSLNPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLLRGSLNPK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 EFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLKE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 MCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 QHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVER 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 RQELALEDPPSEALHSSALKDKGSSLEPRQHFNALDVGASGLNTSHSPSASSRSSHKSSH :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: NP_002 RQELALEDPPSEALHSSALKDKGSSLEPRQHFNTLDVGASGLNTSHSPSASSRSSHKSSH 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 TAMSEPTSTPTKLMAEASTPALPRSATLPQELPVPGLSQAATMPAPLPSPSSCDLTQQLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TAMSEPTSTPTKLMAEASTPALPRSATLPQELPVPGLSQAATMPAPLPSPSSCDLTQQLL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 PQTVLQSTPAPMAQFSAQFSMFQTIKDQLEQRTRILQANIRWQQEELHKIQEQLCLVQDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PQTVLQSTPAPMAQFSAQFSMFQTIKDQLEQRTRILQANIRWQQEELHKIQEQLCLVQDS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 NVQMFLQQPAVSLSFSSTQRPEAQQQLQQRSAAVTQPQLGAGPQLPGQISSAQVTSQHLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 NVQMFLQQPAVSLSFSSTQRPEAQQQLQQRSAAVTQPQLGAGPQLPGQISSAQVTSQHLL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE1 RESSVISTQGPKPMRSSQLMQSSGRSGSSLVSPFSSATAALPPSLNLTTPASTSQDASQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 RESSVISTQGPKPMRSSQLMQSSGRSGSSLVSPFSSATAALPPSLNLTTPASTSQDASQC 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE1 QPSPDFSHDRQLRLLLSQPIQPMMPGSCDARQPSEVSRTGRQVKYAQSQTVFQNPDAHPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QPSPDFSHDRQLRLLLSQPIQPMMPGSCDARQPSEVSRTGRQVKYAQSQTVFQNPDAHPA 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE1 NSSSAPMPVLLMGQAVLHPSFPASQPSPLQPAQARQQPPQHYLQVQAPTSLHSEQQDSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 NSSSAPMPVLLMGQAVLHPSFPASQPSPLQPAQARQQPPQHYLQVQAPTSLHSEQQDSLL 730 740 750 760 770 780 790 800 810 820 pF1KE1 LSTYSQQPGTLGYPQPPPAQPQPLRPPRRVSSLSESSGLQQPPR :::::::::::::::::::::::::::::::::::::::::::: NP_002 LSTYSQQPGTLGYPQPPPAQPQPLRPPRRVSSLSESSGLQQPPR 790 800 810 820 >>XP_005264010 (OMIM: 603347) PREDICTED: neuronal PAS do (889 aa) initn: 5537 init1: 5537 opt: 5537 Z-score: 2858.6 bits: 540.0 E(85289): 1.7e-152 Smith-Waterman score: 5537; 99.9% identity (100.0% similar) in 824 aa overlap (1-824:66-889) 10 20 30 pF1KE1 MDEDEKDRAKRASRNKSEKKRRDQFNVLIK :::::::::::::::::::::::::::::: XP_005 TGTTRLNSEPVPLLCLPLLNCSRKNCIENLMDEDEKDRAKRASRNKSEKKRRDQFNVLIK 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE1 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML 100 110 120 130 140 150 100 110 120 130 140 150 pF1KE1 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML 160 170 180 190 200 210 160 170 180 190 200 210 pF1KE1 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN 220 230 240 250 260 270 220 230 240 250 260 270 pF1KE1 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP 280 290 300 310 320 330 280 290 300 310 320 330 pF1KE1 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHY 340 350 360 370 380 390 340 350 360 370 380 390 pF1KE1 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ 400 410 420 430 440 450 400 410 420 430 440 450 pF1KE1 HFNALDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HFNTLDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ 460 470 480 490 500 510 460 470 480 490 500 510 pF1KE1 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE 520 530 540 550 560 570 520 530 540 550 560 570 pF1KE1 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR 580 590 600 610 620 630 580 590 600 610 620 630 pF1KE1 SAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGRSGSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGRSGSSL 640 650 660 670 680 690 640 650 660 670 680 690 pF1KE1 VSPFSSATAALPPSLNLTTPASTSQDASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VSPFSSATAALPPSLNLTTPASTSQDASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDA 700 710 720 730 740 750 700 710 720 730 740 750 pF1KE1 RQPSEVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RQPSEVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQ 760 770 780 790 800 810 760 770 780 790 800 810 pF1KE1 PAQARQQPPQHYLQVQAPTSLHSEQQDSLLLSTYSQQPGTLGYPQPPPAQPQPLRPPRRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PAQARQQPPQHYLQVQAPTSLHSEQQDSLLLSTYSQQPGTLGYPQPPPAQPQPLRPPRRV 820 830 840 850 860 870 820 pF1KE1 SSLSESSGLQQPPR :::::::::::::: XP_005 SSLSESSGLQQPPR 880 >>XP_005264016 (OMIM: 603347) PREDICTED: neuronal PAS do (835 aa) initn: 5210 init1: 5130 opt: 5130 Z-score: 2650.3 bits: 501.4 E(85289): 7e-141 Smith-Waterman score: 5130; 99.5% identity (99.7% similar) in 769 aa overlap (1-769:66-834) 10 20 30 pF1KE1 MDEDEKDRAKRASRNKSEKKRRDQFNVLIK :::::::::::::::::::::::::::::: XP_005 TGTTRLNSEPVPLLCLPLLNCSRKNCIENLMDEDEKDRAKRASRNKSEKKRRDQFNVLIK 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE1 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML 100 110 120 130 140 150 100 110 120 130 140 150 pF1KE1 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML 160 170 180 190 200 210 160 170 180 190 200 210 pF1KE1 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN 220 230 240 250 260 270 220 230 240 250 260 270 pF1KE1 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP 280 290 300 310 320 330 280 290 300 310 320 330 pF1KE1 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHY 340 350 360 370 380 390 340 350 360 370 380 390 pF1KE1 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ 400 410 420 430 440 450 400 410 420 430 440 450 pF1KE1 HFNALDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HFNTLDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ 460 470 480 490 500 510 460 470 480 490 500 510 pF1KE1 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE 520 530 540 550 560 570 520 530 540 550 560 570 pF1KE1 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR 580 590 600 610 620 630 580 590 600 610 620 630 pF1KE1 SAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGRSGSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGRSGSSL 640 650 660 670 680 690 640 650 660 670 680 690 pF1KE1 VSPFSSATAALPPSLNLTTPASTSQDASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VSPFSSATAALPPSLNLTTPASTSQDASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDA 700 710 720 730 740 750 700 710 720 730 740 750 pF1KE1 RQPSEVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RQPSEVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQ 760 770 780 790 800 810 760 770 780 790 800 810 pF1KE1 PAQARQQPPQHYLQVQAPTSLHSEQQDSLLLSTYSQQPGTLGYPQPPPAQPQPLRPPRRV ::::::::::::::: . : XP_005 PAQARQQPPQHYLQVLGHTL 820 830 >>XP_016859704 (OMIM: 603347) PREDICTED: neuronal PAS do (838 aa) initn: 5208 init1: 5128 opt: 5128 Z-score: 2649.3 bits: 501.2 E(85289): 8e-141 Smith-Waterman score: 5128; 99.7% identity (100.0% similar) in 765 aa overlap (1-765:66-830) 10 20 30 pF1KE1 MDEDEKDRAKRASRNKSEKKRRDQFNVLIK :::::::::::::::::::::::::::::: XP_016 TGTTRLNSEPVPLLCLPLLNCSRKNCIENLMDEDEKDRAKRASRNKSEKKRRDQFNVLIK 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE1 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML 100 110 120 130 140 150 100 110 120 130 140 150 pF1KE1 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML 160 170 180 190 200 210 160 170 180 190 200 210 pF1KE1 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN 220 230 240 250 260 270 220 230 240 250 260 270 pF1KE1 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP 280 290 300 310 320 330 280 290 300 310 320 330 pF1KE1 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHY 340 350 360 370 380 390 340 350 360 370 380 390 pF1KE1 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ 400 410 420 430 440 450 400 410 420 430 440 450 pF1KE1 HFNALDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HFNTLDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ 460 470 480 490 500 510 460 470 480 490 500 510 pF1KE1 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE 520 530 540 550 560 570 520 530 540 550 560 570 pF1KE1 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR 580 590 600 610 620 630 580 590 600 610 620 630 pF1KE1 SAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGRSGSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGRSGSSL 640 650 660 670 680 690 640 650 660 670 680 690 pF1KE1 VSPFSSATAALPPSLNLTTPASTSQDASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSPFSSATAALPPSLNLTTPASTSQDASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDA 700 710 720 730 740 750 700 710 720 730 740 750 pF1KE1 RQPSEVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQPSEVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQ 760 770 780 790 800 810 760 770 780 790 800 810 pF1KE1 PAQARQQPPQHYLQVQAPTSLHSEQQDSLLLSTYSQQPGTLGYPQPPPAQPQPLRPPRRV ::::::::::::::. XP_016 PAQARQQPPQHYLQILSVLETQK 820 830 >>XP_011509544 (OMIM: 603347) PREDICTED: neuronal PAS do (794 aa) initn: 4762 init1: 4762 opt: 4762 Z-score: 2461.9 bits: 466.4 E(85289): 2.2e-130 Smith-Waterman score: 5278; 96.2% identity (96.4% similar) in 824 aa overlap (1-824:1-794) 10 20 30 40 50 60 pF1KE1 MDEDEKDRAKRASRNKSEKKRRDQFNVLIKELSSMLPGNTRKMDKTTVLEKVIGFLQKHN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MDEDEKDRAKRASRNKSEKKRRDQFNVLIKELSSMLPGNTRKMDKTTVLEKVIGFLQKHN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 EVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGHL ::::::::::::::::::::::::::::::: XP_011 EVSAQTEICDIQQDWKPSFLSNEEFTQLMLE----------------------------- 70 80 90 130 140 150 160 170 180 pF1KE1 PSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLLRGSLNPK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 -SDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLLRGSLNPK 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE1 EFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLKE 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE1 MCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCH 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE1 QHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVER 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE1 RQELALEDPPSEALHSSALKDKGSSLEPRQHFNALDVGASGLNTSHSPSASSRSSHKSSH :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: XP_011 RQELALEDPPSEALHSSALKDKGSSLEPRQHFNTLDVGASGLNTSHSPSASSRSSHKSSH 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE1 TAMSEPTSTPTKLMAEASTPALPRSATLPQELPVPGLSQAATMPAPLPSPSSCDLTQQLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TAMSEPTSTPTKLMAEASTPALPRSATLPQELPVPGLSQAATMPAPLPSPSSCDLTQQLL 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE1 PQTVLQSTPAPMAQFSAQFSMFQTIKDQLEQRTRILQANIRWQQEELHKIQEQLCLVQDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQTVLQSTPAPMAQFSAQFSMFQTIKDQLEQRTRILQANIRWQQEELHKIQEQLCLVQDS 460 470 480 490 500 510 550 560 570 580 590 600 pF1KE1 NVQMFLQQPAVSLSFSSTQRPEAQQQLQQRSAAVTQPQLGAGPQLPGQISSAQVTSQHLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NVQMFLQQPAVSLSFSSTQRPEAQQQLQQRSAAVTQPQLGAGPQLPGQISSAQVTSQHLL 520 530 540 550 560 570 610 620 630 640 650 660 pF1KE1 RESSVISTQGPKPMRSSQLMQSSGRSGSSLVSPFSSATAALPPSLNLTTPASTSQDASQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RESSVISTQGPKPMRSSQLMQSSGRSGSSLVSPFSSATAALPPSLNLTTPASTSQDASQC 580 590 600 610 620 630 670 680 690 700 710 720 pF1KE1 QPSPDFSHDRQLRLLLSQPIQPMMPGSCDARQPSEVSRTGRQVKYAQSQTVFQNPDAHPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QPSPDFSHDRQLRLLLSQPIQPMMPGSCDARQPSEVSRTGRQVKYAQSQTVFQNPDAHPA 640 650 660 670 680 690 730 740 750 760 770 780 pF1KE1 NSSSAPMPVLLMGQAVLHPSFPASQPSPLQPAQARQQPPQHYLQVQAPTSLHSEQQDSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSSSAPMPVLLMGQAVLHPSFPASQPSPLQPAQARQQPPQHYLQVQAPTSLHSEQQDSLL 700 710 720 730 740 750 790 800 810 820 pF1KE1 LSTYSQQPGTLGYPQPPPAQPQPLRPPRRVSSLSESSGLQQPPR :::::::::::::::::::::::::::::::::::::::::::: XP_011 LSTYSQQPGTLGYPQPPPAQPQPLRPPRRVSSLSESSGLQQPPR 760 770 780 790 >>XP_005264018 (OMIM: 603347) PREDICTED: neuronal PAS do (700 aa) initn: 4740 init1: 4740 opt: 4740 Z-score: 2451.4 bits: 464.3 E(85289): 8.3e-130 Smith-Waterman score: 4740; 99.9% identity (100.0% similar) in 700 aa overlap (125-824:1-700) 100 110 120 130 140 150 pF1KE1 GFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDS :::::::::::::::::::::::::::::: XP_005 MDQNLLNFLPEQEHSEVYKILSSHMLVTDS 10 20 30 160 170 180 190 200 210 pF1KE1 PSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSR 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE1 PCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGY 100 110 120 130 140 150 280 290 300 310 320 330 pF1KE1 LPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITY 160 170 180 190 200 210 340 350 360 370 380 390 pF1KE1 HQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQHFNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. XP_005 HQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQHFNT 220 230 240 250 260 270 400 410 420 430 440 450 pF1KE1 LDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQELPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQELPV 280 290 300 310 320 330 460 470 480 490 500 510 pF1KE1 PGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLEQRTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLEQRTR 340 350 360 370 380 390 520 530 540 550 560 570 pF1KE1 ILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQRSAAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQRSAAV 400 410 420 430 440 450 580 590 600 610 620 630 pF1KE1 TQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGRSGSSLVSPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGRSGSSLVSPF 460 470 480 490 500 510 640 650 660 670 680 690 pF1KE1 SSATAALPPSLNLTTPASTSQDASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDARQPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSATAALPPSLNLTTPASTSQDASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDARQPS 520 530 540 550 560 570 700 710 720 730 740 750 pF1KE1 EVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQPAQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQPAQA 580 590 600 610 620 630 760 770 780 790 800 810 pF1KE1 RQQPPQHYLQVQAPTSLHSEQQDSLLLSTYSQQPGTLGYPQPPPAQPQPLRPPRRVSSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RQQPPQHYLQVQAPTSLHSEQQDSLLLSTYSQQPGTLGYPQPPPAQPQPLRPPRRVSSLS 640 650 660 670 680 690 820 pF1KE1 ESSGLQQPPR :::::::::: XP_005 ESSGLQQPPR 700 >>XP_016859703 (OMIM: 603347) PREDICTED: neuronal PAS do (843 aa) initn: 4068 init1: 4068 opt: 4127 Z-score: 2135.9 bits: 406.2 E(85289): 3.1e-112 Smith-Waterman score: 5146; 94.3% identity (94.4% similar) in 824 aa overlap (1-824:66-843) 10 20 30 pF1KE1 MDEDEKDRAKRASRNKSEKKRRDQFNVLIK :::::::::::::::::::::::::::::: XP_016 TGTTRLNSEPVPLLCLPLLNCSRKNCIENLMDEDEKDRAKRASRNKSEKKRRDQFNVLIK 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE1 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML 100 110 120 130 140 150 100 110 120 130 140 150 pF1KE1 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML 160 170 180 190 200 210 160 170 180 190 200 210 pF1KE1 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN 220 230 240 250 260 270 220 230 240 250 260 270 pF1KE1 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP 280 290 300 310 320 330 280 290 300 310 320 330 pF1KE1 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHY 340 350 360 370 380 390 340 350 360 370 380 390 pF1KE1 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ 400 410 420 430 440 450 400 410 420 430 440 450 pF1KE1 HFNALDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HFNTLDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ 460 470 480 490 500 510 460 470 480 490 500 510 pF1KE1 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE 520 530 540 550 560 570 520 530 540 550 560 570 pF1KE1 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR 580 590 600 610 620 630 580 590 600 610 620 630 pF1KE1 SAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGRSGSSL ::::::::::::::::::::::::::::::::::::::: XP_016 SAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQ--------------------- 640 650 660 670 640 650 660 670 680 690 pF1KE1 VSPFSSATAALPPSLNLTTPASTSQDASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDA ::::::::::::::::::::::::::::::::::: XP_016 -------------------------DASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDA 680 690 700 700 710 720 730 740 750 pF1KE1 RQPSEVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQPSEVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQ 710 720 730 740 750 760 760 770 780 790 800 810 pF1KE1 PAQARQQPPQHYLQVQAPTSLHSEQQDSLLLSTYSQQPGTLGYPQPPPAQPQPLRPPRRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PAQARQQPPQHYLQVQAPTSLHSEQQDSLLLSTYSQQPGTLGYPQPPPAQPQPLRPPRRV 770 780 790 800 810 820 820 pF1KE1 SSLSESSGLQQPPR :::::::::::::: XP_016 SSLSESSGLQQPPR 830 840 >>XP_016859705 (OMIM: 603347) PREDICTED: neuronal PAS do (789 aa) initn: 4834 init1: 4068 opt: 4085 Z-score: 2114.8 bits: 402.2 E(85289): 4.7e-111 Smith-Waterman score: 4739; 93.5% identity (93.8% similar) in 769 aa overlap (1-769:66-788) 10 20 30 pF1KE1 MDEDEKDRAKRASRNKSEKKRRDQFNVLIK :::::::::::::::::::::::::::::: XP_016 TGTTRLNSEPVPLLCLPLLNCSRKNCIENLMDEDEKDRAKRASRNKSEKKRRDQFNVLIK 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE1 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML 100 110 120 130 140 150 100 110 120 130 140 150 pF1KE1 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML 160 170 180 190 200 210 160 170 180 190 200 210 pF1KE1 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN 220 230 240 250 260 270 220 230 240 250 260 270 pF1KE1 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP 280 290 300 310 320 330 280 290 300 310 320 330 pF1KE1 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHY 340 350 360 370 380 390 340 350 360 370 380 390 pF1KE1 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ 400 410 420 430 440 450 400 410 420 430 440 450 pF1KE1 HFNALDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HFNTLDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ 460 470 480 490 500 510 460 470 480 490 500 510 pF1KE1 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE 520 530 540 550 560 570 520 530 540 550 560 570 pF1KE1 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR 580 590 600 610 620 630 580 590 600 610 620 630 pF1KE1 SAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGRSGSSL ::::::::::::::::::::::::::::::::::::::: XP_016 SAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQ--------------------- 640 650 660 670 640 650 660 670 680 690 pF1KE1 VSPFSSATAALPPSLNLTTPASTSQDASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDA ::::::::::::::::::::::::::::::::::: XP_016 -------------------------DASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDA 680 690 700 700 710 720 730 740 750 pF1KE1 RQPSEVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQPSEVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQ 710 720 730 740 750 760 760 770 780 790 800 810 pF1KE1 PAQARQQPPQHYLQVQAPTSLHSEQQDSLLLSTYSQQPGTLGYPQPPPAQPQPLRPPRRV ::::::::::::::: . : XP_016 PAQARQQPPQHYLQVLGHTL 770 780 >>XP_011509545 (OMIM: 603347) PREDICTED: neuronal PAS do (637 aa) initn: 3713 init1: 3656 opt: 3656 Z-score: 1896.2 bits: 361.4 E(85289): 7e-99 Smith-Waterman score: 3656; 99.5% identity (99.6% similar) in 546 aa overlap (1-546:66-611) 10 20 30 pF1KE1 MDEDEKDRAKRASRNKSEKKRRDQFNVLIK :::::::::::::::::::::::::::::: XP_011 TGTTRLNSEPVPLLCLPLLNCSRKNCIENLMDEDEKDRAKRASRNKSEKKRRDQFNVLIK 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE1 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML 100 110 120 130 140 150 100 110 120 130 140 150 pF1KE1 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML 160 170 180 190 200 210 160 170 180 190 200 210 pF1KE1 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN 220 230 240 250 260 270 220 230 240 250 260 270 pF1KE1 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP 280 290 300 310 320 330 280 290 300 310 320 330 pF1KE1 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHY 340 350 360 370 380 390 340 350 360 370 380 390 pF1KE1 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ 400 410 420 430 440 450 400 410 420 430 440 450 pF1KE1 HFNALDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HFNTLDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ 460 470 480 490 500 510 460 470 480 490 500 510 pF1KE1 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE 520 530 540 550 560 570 520 530 540 550 560 570 pF1KE1 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR ::::::::::::::::::::::::::::::::: : XP_011 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQAHLLTASTYVCTCALGVGLPCMDACLG 580 590 600 610 620 630 580 590 600 610 620 630 pF1KE1 SAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGRSGSSL XP_011 PG >>XP_005264017 (OMIM: 603347) PREDICTED: neuronal PAS do (786 aa) initn: 3502 init1: 3502 opt: 3502 Z-score: 1815.9 bits: 346.9 E(85289): 2.1e-94 Smith-Waterman score: 4587; 87.4% identity (87.5% similar) in 824 aa overlap (1-824:66-786) 10 20 30 pF1KE1 MDEDEKDRAKRASRNKSEKKRRDQFNVLIK :::::::::::::::::::::::::::::: XP_005 TGTTRLNSEPVPLLCLPLLNCSRKNCIENLMDEDEKDRAKRASRNKSEKKRRDQFNVLIK 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE1 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML 100 110 120 130 140 150 100 110 120 130 140 150 pF1KE1 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHML 160 170 180 190 200 210 160 170 180 190 200 210 pF1KE1 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN :::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNV---------- 220 230 240 250 260 220 230 240 250 260 270 pF1KE1 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP XP_005 ------------------------------------------------------------ 280 290 300 310 320 330 pF1KE1 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHY ::::::::::::::::::::::::::: XP_005 ---------------------------------MQFGKGKSCCYRFLTKGQQWIWLQTHY 270 280 290 340 350 360 370 380 390 pF1KE1 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQ 300 310 320 330 340 350 400 410 420 430 440 450 pF1KE1 HFNALDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HFNTLDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ 360 370 380 390 400 410 460 470 480 490 500 510 pF1KE1 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQLE 420 430 440 450 460 470 520 530 540 550 560 570 pF1KE1 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQR 480 490 500 510 520 530 580 590 600 610 620 630 pF1KE1 SAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGRSGSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGRSGSSL 540 550 560 570 580 590 640 650 660 670 680 690 pF1KE1 VSPFSSATAALPPSLNLTTPASTSQDASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VSPFSSATAALPPSLNLTTPASTSQDASQCQPSPDFSHDRQLRLLLSQPIQPMMPGSCDA 600 610 620 630 640 650 700 710 720 730 740 750 pF1KE1 RQPSEVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RQPSEVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQ 660 670 680 690 700 710 760 770 780 790 800 810 pF1KE1 PAQARQQPPQHYLQVQAPTSLHSEQQDSLLLSTYSQQPGTLGYPQPPPAQPQPLRPPRRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PAQARQQPPQHYLQVQAPTSLHSEQQDSLLLSTYSQQPGTLGYPQPPPAQPQPLRPPRRV 720 730 740 750 760 770 820 pF1KE1 SSLSESSGLQQPPR :::::::::::::: XP_005 SSLSESSGLQQPPR 780 824 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 15:58:49 2016 done: Mon Nov 7 15:58:51 2016 Total Scan time: 14.820 Total Display time: 0.270 Function used was FASTA [36.3.4 Apr, 2011]