FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1945, 500 aa 1>>>pF1KE1945 500 - 500 aa - 500 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9889+/-0.000383; mu= 20.1778+/- 0.024 mean_var=74.6576+/-15.631, 0's: 0 Z-trim(113.1): 103 B-trim: 179 in 1/56 Lambda= 0.148435 statistics sampled from 22225 (22329) to 22225 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.63), E-opt: 0.2 (0.262), width: 16 Scan time: 8.680 The best scores are: opt bits E(85289) NP_000952 (OMIM: 145500,601699) prostacyclin synth ( 500) 3345 726.1 5.8e-209 NP_004382 (OMIM: 602172) 7-alpha-hydroxycholest-4- ( 501) 1303 288.8 2.5e-77 NP_000771 (OMIM: 118455) cholesterol 7-alpha-monoo ( 504) 923 207.4 7.9e-53 NP_004811 (OMIM: 270800,603711,613812) 25-hydroxyc ( 506) 829 187.3 9.1e-47 XP_016869491 (OMIM: 270800,603711,613812) PREDICTE ( 528) 782 177.2 1e-43 NP_001311041 (OMIM: 270800,603711,613812) 25-hydro ( 460) 620 142.5 2.5e-33 XP_016866414 (OMIM: 605994) PREDICTED: 24-hydroxyc ( 335) 182 48.6 3.4e-05 XP_011512960 (OMIM: 605994) PREDICTED: 24-hydroxyc ( 371) 182 48.6 3.7e-05 XP_005249228 (OMIM: 605994) PREDICTED: 24-hydroxyc ( 420) 182 48.6 4.1e-05 XP_016866413 (OMIM: 605994) PREDICTED: 24-hydroxyc ( 433) 182 48.7 4.2e-05 XP_016866412 (OMIM: 605994) PREDICTED: 24-hydroxyc ( 435) 182 48.7 4.2e-05 NP_057677 (OMIM: 605994) 24-hydroxycholesterol 7-a ( 469) 182 48.7 4.4e-05 XP_016866410 (OMIM: 605994) PREDICTED: 24-hydroxyc ( 471) 182 48.7 4.4e-05 NP_000777 (OMIM: 601637) lanosterol 14-alpha demet ( 509) 180 48.3 6.3e-05 NP_085125 (OMIM: 611529) cytochrome P450 2S1 precu ( 504) 177 47.6 9.8e-05 NP_001265667 (OMIM: 605994) 24-hydroxycholesterol ( 449) 173 46.7 0.00016 XP_016866411 (OMIM: 605994) PREDICTED: 24-hydroxyc ( 451) 173 46.7 0.00016 NP_001265668 (OMIM: 605994) 24-hydroxycholesterol ( 297) 163 44.4 0.00053 NP_000488 (OMIM: 103900,202010,610613) cytochrome ( 503) 148 41.4 0.0072 >>NP_000952 (OMIM: 145500,601699) prostacyclin synthase (500 aa) initn: 3345 init1: 3345 opt: 3345 Z-score: 3872.5 bits: 726.1 E(85289): 5.8e-209 Smith-Waterman score: 3345; 100.0% identity (100.0% similar) in 500 aa overlap (1-500:1-500) 10 20 30 40 50 60 pF1KE1 MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 HGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 HGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 KARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 KARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 YGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 YGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 LSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITRE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 VVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 YKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 YKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSR 430 440 450 460 470 480 490 500 pF1KE1 YGFGLMQPEHDVPVRYRIRP :::::::::::::::::::: NP_000 YGFGLMQPEHDVPVRYRIRP 490 500 >>NP_004382 (OMIM: 602172) 7-alpha-hydroxycholest-4-en-3 (501 aa) initn: 1292 init1: 907 opt: 1303 Z-score: 1509.2 bits: 288.8 E(85289): 2.5e-77 Smith-Waterman score: 1303; 40.9% identity (69.4% similar) in 506 aa overlap (3-500:4-499) 10 20 30 40 50 pF1KE1 MAWAALLGLLAALL--LLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRM :. .:: : ... : : . : ::: ::::: :..::::.:. : :. :: :: NP_004 MVLWGPVLGALLVVIAGYLCLPGMLRQRRPWEPPLDKGTVPWLGHAMAFRKNMFEFLKRM 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 KEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIF---DVQLPH . ::::.::. .::.: : ..:: :. ... . . .::: :: :. ..: .:: : NP_004 RTKHGDVFTVQLGGQYFTFVMDPLSFGSILKDTQRKLDFGQYAKKLVLKVFGYRSVQGDH 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 YSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLL---GDATEAGSGWHEMGLLDFSYSF . ... : :. :.:.: .: :.: : . .: : ::: .:. : : . NP_004 EMIHSASTKH---LRGDGLKDLNETMLDSLSFVMLTSKGWSLDA-SCWHEDSLFRFCYYI 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 LLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMC :. ::::.:.: ... :: ......: ::..: :.:... . : . .. NP_004 LFTAGYLSLFGYT------KDKEQDLLQAGELFMEFRKFDLLFPRFVYSLLWPREWLEVG 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 SVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPA .. . :.:: .. .. :.:: ..: :.:.:: :: . ..:::.::: ::. NP_004 RLQRLFHKMLSVSHSQEKEGISNWLGNMLQFLREQGVPSAMQDKFNFMMLWASQGNTGPT 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 AFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL .:: ::.:::.:::. ::: : ..: .:. ..:. .. .:. :::::::. :.::: NP_004 SFWALLYLLKHPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTPVLDSVVEETLRL 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE1 TAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLN ::: . : : : .. :..:.:. .:.:: : :::.:: . ::.:. .: ::::.:::: NP_004 RAAPTLLRLVHEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIHPEPTVFKYDRFLN 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE1 PDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADV :.::.: ::.: ::....:.::::.: . : :: .:.. .: :..:...:.::::.. :. NP_004 PNGSRKVDFFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDT 420 430 440 450 460 470 480 490 500 pF1KE1 EIPEFDLSRYGFGLMQPEHDVPVRYRIRP .:. : .:.::: ::: ::: :::..: NP_004 PLPHVDPQRWGFGTMQPSHDVRFRYRLHPTE 480 490 500 >>NP_000771 (OMIM: 118455) cholesterol 7-alpha-monooxyge (504 aa) initn: 675 init1: 349 opt: 923 Z-score: 1069.4 bits: 207.4 E(85289): 7.9e-53 Smith-Waterman score: 923; 33.0% identity (64.2% similar) in 509 aa overlap (1-499:6-502) 10 20 30 40 50 pF1KE1 MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLT . :. .. : :.: . ::.: :::::. : ::.:: ::.:: . :: NP_000 MMTTSLIWGIAIAACCCLWLILGIRRRQT---GEPPLENGLIPYLGCALQFGANPLEFLR 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 RMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPR----TRLDFHAYAIFLMERIFDVQ ..::: .:: . :.:: . .: :: :. . . .. : . : . .: .: . NP_000 ANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPM 60 70 80 90 100 110 120 130 140 150 160 pF1KE1 LPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAG--SGWHEMGLLDFSY . . . . . .: :: . :..:::.:. ::. .. .. . ..: :. .: : NP_000 DGNTTENINDTFIK-TLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCY 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE1 SFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDH ...:::::..: . : : ...: ..: . . .:.:.:...: :. : : . NP_000 RVMFEAGYLTIFGRD-LTR-RDTQ---KAHILNNLDNFKQFDKVFPALVAG-LPIHMFRT 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE1 MCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQ-ARALVLQLWATQGNM ... .: . : : .: :. . .. . ... .... :.. .. :::.:.: NP_000 AHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANT 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE1 GPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVS---QTTTLPQKVLDSTPVLDSVL ::.:: :. ...::::. :. :.. : .: : :: . : : :.. :::::.. NP_000 IPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSII 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE1 SESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFK .:::::..: . : . :... . :: .:.:. : . :.: : . ::::: :: .:: NP_000 KESLRLSSASLNIRTAKEDFTLHLEDGS-YNIRKDDIIALYPQLM-HLDPEIYPDPLTFK 360 370 380 390 400 410 420 430 440 450 460 pF1KE1 YNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLE :.:.:. .:. : :: .: .:: : ::.:.: . : :: .:.. ::::..:.: ...:: NP_000 YDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELE 410 420 430 440 450 460 470 480 490 500 pF1KE1 LINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP ::..... : .: :: :.:.. : .:. .:... NP_000 LIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFKHL 470 480 490 500 >>NP_004811 (OMIM: 270800,603711,613812) 25-hydroxychole (506 aa) initn: 695 init1: 277 opt: 829 Z-score: 960.6 bits: 187.3 E(85289): 9.1e-47 Smith-Waterman score: 882; 34.1% identity (63.9% similar) in 499 aa overlap (7-499:22-505) 10 20 30 40 pF1KE1 MAWAALLGLLAALLLLLL-LSRRRTRRPGEPPLDLGSIPWLGYAL :.: :::::: : : ::::::::::: : .:.:: .: NP_004 MAGEVSAATGRFSLERLGLPGLALAAALLLLALCLLVRRTRRPGEPPLIKGWLPYLGVVL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE1 DFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLM .. :: :. ....::: ::.:.::.:.: .::: .:. :. . . .:.:.... :. NP_004 NLRKDPLRFMKTLQKQHGDTFTVLLGGKYITFILDPFQYQLVI-KNHKQLSFRVFSNKLL 70 80 90 100 110 110 120 130 140 150 160 pF1KE1 ERIFDV-QLPHYSPSDEKARMKLTLLH-RELQALTEAMYTNLHAVLLGDATEAGSGWHEM :. :.. :: . ... .. .:. . :. : :.:. ::. :. . .. : : NP_004 EKAFSISQLQKNHDMNDELHLCYQFLQGKSLDILLESMMQNLKQVFEPQLLKTTS-WDTA 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE1 GLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSL : : :.... . :.:: . ... .. : : ..: . :. ... NP_004 ELYPFCSSIIFEITFTTIYGKVIVCDNNKFISELR-------DDFLKFDDKFAYLV-SNI 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE1 SVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQ-L . .. :.. .. : .: .::. :. ..: ::.. : :... : : : NP_004 PIELLGNVKSIREKIIKCFSSEKLAKMQGWSEVFQSRQDVLEKYYVHEDLEIGAHHLGFL 240 250 260 270 280 290 290 300 310 320 330 pF1KE1 WATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQ--TTTLPQKVLDSTP ::. .: :. :: . .::..:::.:::: :.. .: .. : .. : .. ::: NP_004 WASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHLTREQLDSLI 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE1 VLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYT :.: . :.:::.. : : ::.. : .. .:.:: . .:: . . ::::. NP_004 CLESSIFEALRLSSYSTTIRFVEEDLTLSSETG-DYCVRKGDLVAIFPPVL-HGDPEIFE 360 370 380 390 400 400 410 420 430 440 450 pF1KE1 DPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVL :: :.:.::.. ::..: :.: ::.:: : ::.:.: ..: :: .:. :::.. ..: NP_004 APEEFRYDRFIE-DGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEIKQLLVILL 410 420 430 440 450 460 460 470 480 490 500 pF1KE1 VHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP ...:::.:. : : .. :: ::.. :. :: ::... NP_004 TYFDLEIID-DKPIG-LNYSRLLFGIQYPDSDVLFRYKVKS 470 480 490 500 >>XP_016869491 (OMIM: 270800,603711,613812) PREDICTED: 2 (528 aa) initn: 723 init1: 240 opt: 782 Z-score: 905.9 bits: 177.2 E(85289): 1e-43 Smith-Waterman score: 835; 33.1% identity (63.5% similar) in 480 aa overlap (25-499:63-527) 10 20 30 40 50 pF1KE1 MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFL :::::::: : .:.:: .:.. :: :. XP_016 EDIQLMLTDCNPLRQDLDIYTLQLPEKTCLRRPGEPPLIKGWLPYLGVVLNLRKDPLRFM 40 50 60 70 80 90 60 70 80 90 100 110 pF1KE1 TRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDV-QLP ....::: ::.:.::.:.: .::: .:. :. . . .:.:.... :.:. :.. :: XP_016 KTLQKQHGDTFTVLLGGKYITFILDPFQYQLVI-KNHKQLSFRVFSNKLLEKAFSISQLQ 100 110 120 130 140 150 120 130 140 150 160 170 pF1KE1 HYSPSDEKARMKLTLLH-RELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFL . ... .. .:. . :. : :.:. ::. :. . .. : : : : :.. XP_016 KNHDMNDELHLCYQFLQGKSLDILLESMMQNLKQVFEPQLLKTTS-WDTAELYPFCSSII 160 170 180 190 200 210 180 190 200 210 220 230 pF1KE1 LRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCS .. . :.:: . ... .. : : : : : . :. ... . .. : XP_016 FEITFTTIYGKVIVCDNNKFISELR----DDFLKF---DDKFAYLV-SNIPIELLGNVKS 220 230 240 250 260 240 250 260 270 280 290 pF1KE1 VKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQ-LWATQGNMGPA .. .. : .: .::. :. ..: ::.. : :... : : :::. .: :. XP_016 IREKIIKCFSSEKLAKMQGWSEVFQSRQDVLEKYYVHEDLEIGAHHLGFLWASVANTIPT 270 280 290 300 310 320 300 310 320 330 340 pF1KE1 AFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQ--TTTLPQKVLDSTPVLDSVLSESL :: . .::..:::.:::: :.. .: .. : .. : .. ::: :.: . :.: XP_016 MFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHLTREQLDSLICLESSIFEAL 330 340 350 360 370 380 350 360 370 380 390 400 pF1KE1 RLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRF ::.. : : ::.. : .. .:.:: . .:: . . ::::. :: :.:.:: XP_016 RLSSYSTTIRFVEEDLTLSSETG-DYCVRKGDLVAIFPPVL-HGDPEIFEAPEEFRYDRF 390 400 410 420 430 440 410 420 430 440 450 460 pF1KE1 LNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINA .. ::..: :.: ::.:: : ::.:.: ..: :: .:. :::.. ..:...:::.:. XP_016 IE-DGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEIKQLLVILLTYFDLEIID- 450 460 470 480 490 470 480 490 500 pF1KE1 DVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP : : .. :: ::.. :. :: ::... XP_016 DKPIG-LNYSRLLFGIQYPDSDVLFRYKVKS 500 510 520 >>NP_001311041 (OMIM: 270800,603711,613812) 25-hydroxych (460 aa) initn: 483 init1: 277 opt: 620 Z-score: 719.2 bits: 142.5 E(85289): 2.5e-33 Smith-Waterman score: 620; 32.1% identity (61.4% similar) in 402 aa overlap (7-402:22-411) 10 20 30 40 pF1KE1 MAWAALLGLLAALLLLLL-LSRRRTRRPGEPPLDLGSIPWLGYAL :.: :::::: : : ::::::::::: : .:.:: .: NP_001 MAGEVSAATGRFSLERLGLPGLALAAALLLLALCLLVRRTRRPGEPPLIKGWLPYLGVVL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE1 DFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLM .. :: :. ....::: ::.:.::.:.: .::: .:. :. . . .:.:.... :. NP_001 NLRKDPLRFMKTLQKQHGDTFTVLLGGKYITFILDPFQYQLVI-KNHKQLSFRVFSNKLL 70 80 90 100 110 110 120 130 140 150 160 pF1KE1 ERIFDV-QLPHYSPSDEKARMKLTLLH-RELQALTEAMYTNLHAVLLGDATEAGSGWHEM :. :.. :: . ... .. .:. . :. : :.:. ::. :. . .. : : NP_001 EKAFSISQLQKNHDMNDELHLCYQFLQGKSLDILLESMMQNLKQVFEPQLLKTTS-WDTA 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE1 GLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSL : : :.... . :.:: . ... .. : : ..: . :. ... NP_001 ELYPFCSSIIFEITFTTIYGKVIVCDNNKFISELR-------DDFLKFDDKFAYLV-SNI 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE1 SVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQ-L . .. :.. .. : .: .::. :. ..: ::.. : :... : : : NP_001 PIELLGNVKSIREKIIKCFSSEKLAKMQGWSEVFQSRQDVLEKYYVHEDLEIGAHHLGFL 240 250 260 270 280 290 290 300 310 320 330 pF1KE1 WATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQ--TTTLPQKVLDSTP ::. .: :. :: . .::..:::.:::: :.. .: .. : .. : .. ::: NP_001 WASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHLTREQLDSLI 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE1 VLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYT :.: . :.:::.. : : ::.. : .. .:.:: . .:: . . ::::. NP_001 CLESSIFEALRLSSYSTTIRFVEEDLTLSSETG-DYCVRKGDLVAIFPPVL-HGDPEIFE 360 370 380 390 400 400 410 420 430 440 450 pF1KE1 DPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVL :: NP_001 APEQTVLTGETRGMEITELSNLYFCTAYSREKWRRERRKIHTHILVYLIILQ 410 420 430 440 450 460 >>XP_016866414 (OMIM: 605994) PREDICTED: 24-hydroxychole (335 aa) initn: 207 init1: 132 opt: 182 Z-score: 214.2 bits: 48.6 E(85289): 3.4e-05 Smith-Waterman score: 211; 24.2% identity (50.0% similar) in 360 aa overlap (9-362:11-313) 10 20 30 40 50 pF1KE1 MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMK .:. : :.:::.:. ::: : : :::.: ...::: :. . . XP_016 MELISPTVIIILGCLALFLLLQRKNLRRP---PCIKGWIPWIGVGFEFGKAPLEFIEKAR 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 EKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPS :.: :::... : .: . . .. . :. ..::. . .. : .. . XP_016 IKYGPIFTVFAMGNRMTFVTEEEGIN--VFLKSKKVDFELAVQNIVYRTASIPKNVFLAL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 DEK------ARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFL :: ..: . ::. ::: .. .:. . : : : .:.. : XP_016 HEKLYIMLKGKMGTVNLHQFTGQLTEELHEQLENL----------GTH--GTMDLNN--L 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 LRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCS .: .: :: . . ..: . .. :: . : : :.: XP_016 VR--HL-LYPVTVNMLFNKSLFSTNKKKIKEFHQYFQ--------------VYDEDF--E 170 180 190 200 240 250 260 270 280 290 pF1KE1 VKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAA :.: : : : .:: ...:.: : .. . .. : ...: .: XP_016 YGSQL-----PECLLRNWSKSK---KWFLELFEKNIPDIKACKS------AKDNSM--VA 210 220 230 240 300 310 320 330 340 350 pF1KE1 FWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLT :: : ..:..:. :. . :.. .: . ... . :.. .. . :..:: XP_016 FWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVS---EDDLENLLLIKWCVLETIRLK 250 260 270 280 290 300 360 370 380 390 400 410 pF1KE1 AAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNP : :::.:: XP_016 APGVITRKVVKPVEILVVCSVRGSDVYYFNTL 310 320 330 >>XP_011512960 (OMIM: 605994) PREDICTED: 24-hydroxychole (371 aa) initn: 244 init1: 132 opt: 182 Z-score: 213.6 bits: 48.6 E(85289): 3.7e-05 Smith-Waterman score: 270; 24.7% identity (51.1% similar) in 372 aa overlap (9-362:11-349) 10 20 30 40 50 pF1KE1 MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMK .:. : :.:::.:. ::: : : :::.: ...::: :. . . XP_011 MELISPTVIIILGCLALFLLLQRKNLRRP---PCIKGWIPWIGVGFEFGKAPLEFIEKAR 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 EKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPS :.: :::... : .: . . .. . :. ..::. . .. : .. . XP_011 IKYGPIFTVFAMGNRMTFVTEEEGIN--VFLKSKKVDFELAVQNIVYRTASIPKNVFLAL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 DEK------ARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFL :: ..: . ::. ::: .. .:. . : : : .:.. : XP_011 HEKLYIMLKGKMGTVNLHQFTGQLTEELHEQLENL----------GTH--GTMDLNN--L 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 LRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQL-DRLLPKLARGSLSVGDKDHMC .: .: :: . . ..: . .. :: . :. :. .. :.. : XP_011 VR--HL-LYPVTVNMLFNKSLFSTNKKKIKEFHQYFQVYDE--------DFEYGSQLPEC 170 180 190 200 210 240 250 260 270 280 pF1KE1 SV----KSRLW------KLLSPARLARRAH-RSKWLESYLLHLEEMGVSEEMQARALVLQ . ::. : : . . . :. : : . : . : .:.: . .: XP_011 LLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSMTLLQATLDIVETETSKENSPNYGLLL 220 230 240 250 260 270 290 300 310 320 330 340 pF1KE1 LWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPV :::. .: :.::: : ..:..:. :. . :.. .: . ... . :.. . XP_011 LWASLSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVS---EDDLENLLL 280 290 300 310 320 350 360 370 380 390 400 pF1KE1 LDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTD . . :..:: : :::.:: XP_011 IKWCVLETIRLKAPGVITRKVVKPVEILVVCSVRGSDVYYFNTL 330 340 350 360 370 >>XP_005249228 (OMIM: 605994) PREDICTED: 24-hydroxychole (420 aa) initn: 347 init1: 132 opt: 182 Z-score: 212.9 bits: 48.6 E(85289): 4.1e-05 Smith-Waterman score: 341; 25.1% identity (52.0% similar) in 454 aa overlap (9-444:11-417) 10 20 30 40 50 pF1KE1 MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMK .:. : :.:::.:. ::: : : :::.: ...::: :. . . XP_005 MELISPTVIIILGCLALFLLLQRKNLRRP---PCIKGWIPWIGVGFEFGKAPLEFIEKAR 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 EKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPS :.: :::... : .: . . .. . :. ..::. . .. : .. . XP_005 IKYGPIFTVFAMGNRMTFVTEEEGIN--VFLKSKKVDFELAVQNIVYRTASIPKNVFLAL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 DEK------ARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFL :: ..: . ::. ::: .. .:. . : : : .:.. : XP_005 HEKLYIMLKGKMGTVNLHQFTGQLTEELHEQLENL----------GTH--GTMDLNN--L 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 LRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQL-DRLLPKLARGSLSVGDKDHMC .: .: :: . . ..: . .. :: . :. :. .. :.. : XP_005 VR--HL-LYPVTVNMLFNKSLFSTNKKKIKEFHQYFQVYDE--------DFEYGSQLPEC 170 180 190 200 210 240 250 260 270 280 pF1KE1 SV----KSRLW------KLLSPARLARRAH-RSKWLESYLLHLEEMGVSEEMQARALVLQ . ::. : : . . . :. : : . : . : .:.: . .: XP_005 LLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSMTLLQATLDIVETETSKENSPNYGLLL 220 230 240 250 260 270 290 300 310 320 330 340 pF1KE1 LWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPV :::. .: :.::: : ..:..:. :. . :.. .: . ... . :.. . XP_005 LWASLSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVS---EDDLENLLL 280 290 300 310 320 350 360 370 380 390 400 pF1KE1 LDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTD . . :..:: : :::.:: . . .. . :: :.: :: .:.:. . . XP_005 IKWCVLETIRLKAPGVITRKVVKPVEI-----LNYIIPSGDLLMLSPFWL-HRNPKYFPE 330 340 350 360 370 380 410 420 430 440 450 460 pF1KE1 PEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLV ::.:: .:. . . ::..: : . : .:.:. .: .: XP_005 PELFKPERWKKAN-LEKHSF------LDCF-MAFGSGKFQCPARKGF 390 400 410 420 470 480 490 500 pF1KE1 HLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP >>XP_016866413 (OMIM: 605994) PREDICTED: 24-hydroxychole (433 aa) initn: 244 init1: 132 opt: 182 Z-score: 212.7 bits: 48.7 E(85289): 4.2e-05 Smith-Waterman score: 333; 24.1% identity (51.3% similar) in 497 aa overlap (9-499:11-432) 10 20 30 40 50 pF1KE1 MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMK .:. : :.:::.:. ::: : : :::.: ...::: :. . . XP_016 MELISPTVIIILGCLALFLLLQRKNLRRP---PCIKGWIPWIGVGFEFGKAPLEFIEKAR 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 EKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPS :.: :::... : .: . . .. . :. ..::. . .. : .. . XP_016 IKYGPIFTVFAMGNRMTFVTEEEGIN--VFLKSKKVDFELAVQNIVYRTASIPKNVFLAL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 DEK------ARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFL :: ..: . ::. ::: .. .:. . : : : .:.. : XP_016 HEKLYIMLKGKMGTVNLHQFTGQLTEELHEQLENL----------GTH--GTMDLNN--L 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 LRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCS .: :: . . ..: . .. :: . : : :.: XP_016 VRH---LLYPVTVNMLFNKSLFSTNKKKIKEFHQYFQ--------------VYDEDF--E 170 180 190 200 240 250 260 270 280 290 pF1KE1 VKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAA :.: : : : .:: ...:.: : .. . .. : ...: .: XP_016 YGSQL-----PECLLRNWSKSK---KWFLELFEKNIPDIKACKS------AKDNSM--VA 210 220 230 240 300 310 320 330 340 350 pF1KE1 FWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLT :: : ..:..:. :. . :.. .: . . . . :.. .. . :..:: XP_016 FWTLAYVLSHPDIHKAIMEGISSVFGKAGK---DKIKVSEDDLENLLLIKWCVLETIRLK 250 260 270 280 290 300 360 370 380 390 400 410 pF1KE1 AAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNP : :::.:: . . .. . :: :.: :: .:.:. . .::.:: .:. . XP_016 APGVITRKVVKPVEI-----LNYIIPSGDLLMLSPFWL-HRNPKYFPEPELFKPERWKKA 310 320 330 340 350 420 430 440 450 460 470 pF1KE1 DGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVE . ::..: : . : .:.:. .: .: .:. ... ..:.: . : :.. XP_016 N-LEKHSF------LDCF-MAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLD---P 360 370 380 390 400 480 490 500 pF1KE1 IPEFDLSRYGFGLMQPEHDVPVRYRIRP .:. . . :. ::: . ..:. : XP_016 LPKQSYLHL-VGVPQPEGQCRIEYKQRI 410 420 430 500 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 15:50:05 2016 done: Mon Nov 7 15:50:06 2016 Total Scan time: 8.680 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]