FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE2181, 240 aa
  1>>>pF1KE2181 240 - 240 aa - 240 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.0512+/-0.000305; mu= 16.3535+/- 0.019
 mean_var=67.7617+/-13.619, 0's: 0 Z-trim(117.8): 13  B-trim: 862 in 2/53
 Lambda= 0.155805
 statistics sampled from 30045 (30058) to 30045 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.727), E-opt: 0.2 (0.352), width:  16
 Scan time:  5.950

The best scores are:                                      opt bits E(85289)
NP_444283 (OMIM: 606388) acyl-coenzyme A thioester ( 240) 1636 376.0 3.2e-104
XP_011507444 (OMIM: 606388) PREDICTED: acyl-coenzy ( 176) 1198 277.4 1.1e-74
NP_872384 (OMIM: 615653) acyl-coenzyme A thioester ( 247)  543 130.3   3e-30
XP_011507723 (OMIM: 615653) PREDICTED: acyl-coenzy ( 289)  427 104.3 2.4e-22


>>NP_444283 (OMIM: 606388) acyl-coenzyme A thioesterase   (240 aa)
 initn: 1636 init1: 1636 opt: 1636  Z-score: 1992.1  bits: 376.0 E(85289): 3.2e-104
Smith-Waterman score: 1636; 99.6% identity (99.6% similar) in 240 aa overlap (1-240:1-240)

               10        20        30        40        50        60
pF1KE2 MLRSCAARLRTLGALCRPPVGRRLPGSEPRPELRSFSSEEVILKDCSVPNPSWNKDLRLL
       :::::::::::::::: :::::::::::::::::::::::::::::::::::::::::::
NP_444 MLRSCAARLRTLGALCLPPVGRRLPGSEPRPELRSFSSEEVILKDCSVPNPSWNKDLRLL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 FDQFMKKCEDGSWKRLPSYKRTPTEWIQDFKTHFLDPKLMKEEQMSQAQLFTRSFDDGLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 FDQFMKKCEDGSWKRLPSYKRTPTEWIQDFKTHFLDPKLMKEEQMSQAQLFTRSFDDGLG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 FEYVMFYNDIEKRMVCLFQGGPYLEGPPGFIHGGAIATMIDATVGMCAMMAGGIVMTANL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 FEYVMFYNDIEKRMVCLFQGGPYLEGPPGFIHGGAIATMIDATVGMCAMMAGGIVMTANL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 NINYKRPIPLCSVVMINSQLDKVEGRKFFVSCNVQSVDEKTLYSEATSLFIKLNPAKSLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 NINYKRPIPLCSVVMINSQLDKVEGRKFFVSCNVQSVDEKTLYSEATSLFIKLNPAKSLT
              190       200       210       220       230       240

>>XP_011507444 (OMIM: 606388) PREDICTED: acyl-coenzyme A  (176 aa)
 initn: 1198 init1: 1198 opt: 1198  Z-score: 1461.9  bits: 277.4 E(85289): 1.1e-74
Smith-Waterman score: 1198; 100.0% identity (100.0% similar) in 176 aa overlap (65-240:1-176)

           40        50        60        70        80        90    
pF1KE2 SFSSEEVILKDCSVPNPSWNKDLRLLFDQFMKKCEDGSWKRLPSYKRTPTEWIQDFKTHF
                                     ::::::::::::::::::::::::::::::
XP_011                               MKKCEDGSWKRLPSYKRTPTEWIQDFKTHF
                                             10        20        30

          100       110       120       130       140       150    
pF1KE2 LDPKLMKEEQMSQAQLFTRSFDDGLGFEYVMFYNDIEKRMVCLFQGGPYLEGPPGFIHGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDPKLMKEEQMSQAQLFTRSFDDGLGFEYVMFYNDIEKRMVCLFQGGPYLEGPPGFIHGG
               40        50        60        70        80        90

          160       170       180       190       200       210    
pF1KE2 AIATMIDATVGMCAMMAGGIVMTANLNINYKRPIPLCSVVMINSQLDKVEGRKFFVSCNV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AIATMIDATVGMCAMMAGGIVMTANLNINYKRPIPLCSVVMINSQLDKVEGRKFFVSCNV
              100       110       120       130       140       150

          220       230       240
pF1KE2 QSVDEKTLYSEATSLFIKLNPAKSLT
       ::::::::::::::::::::::::::
XP_011 QSVDEKTLYSEATSLFIKLNPAKSLT
              160       170      

>>NP_872384 (OMIM: 615653) acyl-coenzyme A thioesterase   (247 aa)
 initn: 513 init1: 384 opt: 543  Z-score: 664.1  bits: 130.3 E(85289): 3e-30
Smith-Waterman score: 543; 38.3% identity (68.7% similar) in 243 aa overlap (1-233:1-239)

                   10        20             30        40        50 
pF1KE2 MLRSC---AARL-RTLGALCRPPVGRRL-P----GSEPRPELRSFSSEEVILKDCSVPNP
       :.: :   :::: .  : :  : .  :: :    ::     .  :  :.. ::: ..:: 
NP_872 MIRRCFQVAARLGHHRGLLEAPRILPRLNPASAFGSSTDSMFSRFLPEKTDLKDYALPNA
               10        20        30        40        50        60

              60        70        80        90       100       110 
pF1KE2 SWNKDLRLLFDQFMKKCEDGSWKRLPSYKRTPTEWIQDFKTHFLDPKLMKEEQMSQAQLF
       :: .:.  :...:..: ....: .:::.: .  . :. .:   :   :    . .. ..:
NP_872 SWCSDMLSLYQEFLEKTKSSGWIKLPSFK-SNRDHIRGLK---LPSGLAVSSDKGDCRIF
               70        80         90          100       110      

              120       130       140       150       160       170
pF1KE2 TRSFD-DGLGFEYVMFYNDIEKRMVCLFQGGPYLEGPPGFIHGGAIATMIDATVGMCAMM
       :: .. .: :::::.:..  .:. ::::: : :::::::: :::..:.:.: : .  :..
NP_872 TRCIQVEGQGFEYVIFFQPTQKKSVCLFQPGSYLEGPPGFAHGGSLAAMMDETFSKTAFL
        120       130       140       150       160       170      

              180       190       200       210       220       230
pF1KE2 AGGIVMTANLNINYKRPIPLCSVVMINSQLDKVEGRKFFVSCNVQSVDEKTLYSEATSLF
       ::  ..: .::: .:  ::. :.:... ..::.: .:...:: ..: :..:.:......:
NP_872 AGEGLFTLSLNIRFKNLIPVDSLVVMDVEVDKIEDQKLYMSCIAHSRDQQTVYAKSSGVF
        180       190       200       210       220       230      

              240 
pF1KE2 IKLNPAKSLT 
       ..:        
NP_872 LQLQLEEESPQ
        240       

>>XP_011507723 (OMIM: 615653) PREDICTED: acyl-coenzyme A  (289 aa)
 initn: 397 init1: 268 opt: 427  Z-score: 522.2  bits: 104.3 E(85289): 2.4e-22
Smith-Waterman score: 427; 38.9% identity (64.5% similar) in 203 aa overlap (1-193:1-199)

                   10        20             30        40        50 
pF1KE2 MLRSC---AARL-RTLGALCRPPVGRRL-P----GSEPRPELRSFSSEEVILKDCSVPNP
       :.: :   :::: .  : :  : .  :: :    ::     .  :  :.. ::: ..:: 
XP_011 MIRRCFQVAARLGHHRGLLEAPRILPRLNPASAFGSSTDSMFSRFLPEKTDLKDYALPNA
               10        20        30        40        50        60

              60        70        80        90       100       110 
pF1KE2 SWNKDLRLLFDQFMKKCEDGSWKRLPSYKRTPTEWIQDFKTHFLDPKLMKEEQMSQAQLF
       :: .:.  :...:..: ....: .:::.: .  . :. .:   :   :    . .. ..:
XP_011 SWCSDMLSLYQEFLEKTKSSGWIKLPSFK-SNRDHIRGLK---LPSGLAVSSDKGDCRIF
               70        80         90          100       110      

              120       130       140       150       160       170
pF1KE2 TRSFD-DGLGFEYVMFYNDIEKRMVCLFQGGPYLEGPPGFIHGGAIATMIDATVGMCAMM
       :: .. .: :::::.:..  .:. ::::: : :::::::: :::..:.:.: : .  :..
XP_011 TRCIQVEGQGFEYVIFFQPTQKKSVCLFQPGSYLEGPPGFAHGGSLAAMMDETFSKTAFL
        120       130       140       150       160       170      

              180       190       200       210       220       230
pF1KE2 AGGIVMTANLNINYKRPIPLCSVVMINSQLDKVEGRKFFVSCNVQSVDEKTLYSEATSLF
       ::  ..: .::: .:. .:  .:                                     
XP_011 AGEGLFTLSLNIRFKKCFPSAAVGRRVSPVTVTVPAGEPLPPLPASCLLPPLPASCLLPP
        180       190       200       210       220       230      




240 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Mon Nov  7 15:48:08 2016 done: Mon Nov  7 15:48:08 2016
 Total Scan time:  5.950 Total Display time: -0.020

Function used was FASTA [36.3.4 Apr, 2011]