FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6752, 625 aa 1>>>pF1KE6752 625 - 625 aa - 625 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7635+/-0.000418; mu= 22.2637+/- 0.026 mean_var=60.0756+/-12.075, 0's: 0 Z-trim(109.7): 9 B-trim: 212 in 1/52 Lambda= 0.165472 statistics sampled from 17884 (17891) to 17884 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.572), E-opt: 0.2 (0.21), width: 16 Scan time: 9.850 The best scores are: opt bits E(85289) NP_001477 (OMIM: 600842,613463) glucokinase regula ( 625) 4042 974.0 0 XP_016859285 (OMIM: 600842,613463) PREDICTED: gluc ( 435) 2827 683.8 3.3e-196 XP_016859286 (OMIM: 600842,613463) PREDICTED: gluc ( 435) 2827 683.8 3.3e-196 XP_011531065 (OMIM: 600842,613463) PREDICTED: gluc ( 333) 2071 503.2 5.8e-142 >>NP_001477 (OMIM: 600842,613463) glucokinase regulatory (625 aa) initn: 4042 init1: 4042 opt: 4042 Z-score: 5208.8 bits: 974.0 E(85289): 0 Smith-Waterman score: 4042; 99.8% identity (99.8% similar) in 625 aa overlap (1-625:1-625) 10 20 30 40 50 60 pF1KE6 MPGTKRFQHVIETPEPGKWELSGYEAAVPITEKSNPLTQDLDKADAENIVRLLGQCDAEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPGTKRFQHVIETPEPGKWELSGYEAAVPITEKSNPLTQDLDKADAENIVRLLGQCDAEI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 FQEEGQALSTYQRLYSESILTTMVQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FQEEGQALSTYQRLYSESILTTMVQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 FNQLMKGLGQKPLYTYLIAGGDRSVVASREGTEDSALHGIEELKKVAAGKKRVIVIGISV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FNQLMKGLGQKPLYTYLIAGGDRSVVASREGTEDSALHGIEELKKVAAGKKRVIVIGISV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 GLSAPFVAGQMDCCMNNTAVFLPVLVGFNPVSMARNDPIEDWSSTFRQVAERMQKMQEKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLSAPFVAGQMDCCMNNTAVFLPVLVGFNPVSMARNDPIEDWSSTFRQVAERMQKMQEKQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 KAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKTVDQGIAASQRCLLEILRTFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKTVDQGIAASQRCLLEILRTFE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 RAHQVTYSQSPKIATLMKSVSTSLEKKGHVYLVGWQTLGIIAIMDGVECIHTFGADFRDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RAHQVTYSQSPKIATLMKSVSTSLEKKGHVYLVGWQTLGIIAIMDGVECIHTFGADFRDV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 RGFLIGDHSDMFNQKAELTNQGPQFTFSQEDFLTSILPSLTEIDTVVFIFTLDDNLTEVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGFLIGDHSDMFNQKAELTNQGPQFTFSQEDFLTSILPSLTEIDTVVFIFTLDDNLTEVQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 TIVEQVKEKTNHIQALAHSTVGQTLPIPLKKLFPSIISITWPLLFFEYEGNFIQKFQREL ::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::: NP_001 TIVEQVKEKTNHIQALAHSTVGQTLLIPLKKLFPSIISITWPLLFFEYEGNFIQKFQREL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 STKWVLNTVSTGAHVLLGKILQNHMLDLRISNSKLFWRALAMLQRFSGQSKARCIESLLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STKWVLNTVSTGAHVLLGKILQNHMLDLRISNSKLFWRALAMLQRFSGQSKARCIESLLR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE6 AIHFPQPLSDDIRAAPISCHVQVAHEKEQVIPIALLSLLFRCSITEAQAHLAAAPSVCEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AIHFPQPLSDDIRAAPISCHVQVAHEKEQVIPIALLSLLFRCSITEAQAHLAAAPSVCEA 550 560 570 580 590 600 610 620 pF1KE6 VRSALAGPGQKRTADPLEILEPDVQ ::::::::::::::::::::::::: NP_001 VRSALAGPGQKRTADPLEILEPDVQ 610 620 >>XP_016859285 (OMIM: 600842,613463) PREDICTED: glucokin (435 aa) initn: 2827 init1: 2827 opt: 2827 Z-score: 3643.5 bits: 683.8 E(85289): 3.3e-196 Smith-Waterman score: 2827; 99.8% identity (99.8% similar) in 435 aa overlap (191-625:1-435) 170 180 190 200 210 220 pF1KE6 EELKKVAAGKKRVIVIGISVGLSAPFVAGQMDCCMNNTAVFLPVLVGFNPVSMARNDPIE :::::::::::::::::::::::::::::: XP_016 MDCCMNNTAVFLPVLVGFNPVSMARNDPIE 10 20 30 230 240 250 260 270 280 pF1KE6 DWSSTFRQVAERMQKMQEKQKAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DWSSTFRQVAERMQKMQEKQKAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKT 40 50 60 70 80 90 290 300 310 320 330 340 pF1KE6 VDQGIAASQRCLLEILRTFERAHQVTYSQSPKIATLMKSVSTSLEKKGHVYLVGWQTLGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VDQGIAASQRCLLEILRTFERAHQVTYSQSPKIATLMKSVSTSLEKKGHVYLVGWQTLGI 100 110 120 130 140 150 350 360 370 380 390 400 pF1KE6 IAIMDGVECIHTFGADFRDVRGFLIGDHSDMFNQKAELTNQGPQFTFSQEDFLTSILPSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IAIMDGVECIHTFGADFRDVRGFLIGDHSDMFNQKAELTNQGPQFTFSQEDFLTSILPSL 160 170 180 190 200 210 410 420 430 440 450 460 pF1KE6 TEIDTVVFIFTLDDNLTEVQTIVEQVKEKTNHIQALAHSTVGQTLPIPLKKLFPSIISIT ::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::: XP_016 TEIDTVVFIFTLDDNLTEVQTIVEQVKEKTNHIQALAHSTVGQTLLIPLKKLFPSIISIT 220 230 240 250 260 270 470 480 490 500 510 520 pF1KE6 WPLLFFEYEGNFIQKFQRELSTKWVLNTVSTGAHVLLGKILQNHMLDLRISNSKLFWRAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WPLLFFEYEGNFIQKFQRELSTKWVLNTVSTGAHVLLGKILQNHMLDLRISNSKLFWRAL 280 290 300 310 320 330 530 540 550 560 570 580 pF1KE6 AMLQRFSGQSKARCIESLLRAIHFPQPLSDDIRAAPISCHVQVAHEKEQVIPIALLSLLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AMLQRFSGQSKARCIESLLRAIHFPQPLSDDIRAAPISCHVQVAHEKEQVIPIALLSLLF 340 350 360 370 380 390 590 600 610 620 pF1KE6 RCSITEAQAHLAAAPSVCEAVRSALAGPGQKRTADPLEILEPDVQ ::::::::::::::::::::::::::::::::::::::::::::: XP_016 RCSITEAQAHLAAAPSVCEAVRSALAGPGQKRTADPLEILEPDVQ 400 410 420 430 >>XP_016859286 (OMIM: 600842,613463) PREDICTED: glucokin (435 aa) initn: 2827 init1: 2827 opt: 2827 Z-score: 3643.5 bits: 683.8 E(85289): 3.3e-196 Smith-Waterman score: 2827; 99.8% identity (99.8% similar) in 435 aa overlap (191-625:1-435) 170 180 190 200 210 220 pF1KE6 EELKKVAAGKKRVIVIGISVGLSAPFVAGQMDCCMNNTAVFLPVLVGFNPVSMARNDPIE :::::::::::::::::::::::::::::: XP_016 MDCCMNNTAVFLPVLVGFNPVSMARNDPIE 10 20 30 230 240 250 260 270 280 pF1KE6 DWSSTFRQVAERMQKMQEKQKAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DWSSTFRQVAERMQKMQEKQKAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKT 40 50 60 70 80 90 290 300 310 320 330 340 pF1KE6 VDQGIAASQRCLLEILRTFERAHQVTYSQSPKIATLMKSVSTSLEKKGHVYLVGWQTLGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VDQGIAASQRCLLEILRTFERAHQVTYSQSPKIATLMKSVSTSLEKKGHVYLVGWQTLGI 100 110 120 130 140 150 350 360 370 380 390 400 pF1KE6 IAIMDGVECIHTFGADFRDVRGFLIGDHSDMFNQKAELTNQGPQFTFSQEDFLTSILPSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IAIMDGVECIHTFGADFRDVRGFLIGDHSDMFNQKAELTNQGPQFTFSQEDFLTSILPSL 160 170 180 190 200 210 410 420 430 440 450 460 pF1KE6 TEIDTVVFIFTLDDNLTEVQTIVEQVKEKTNHIQALAHSTVGQTLPIPLKKLFPSIISIT ::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::: XP_016 TEIDTVVFIFTLDDNLTEVQTIVEQVKEKTNHIQALAHSTVGQTLLIPLKKLFPSIISIT 220 230 240 250 260 270 470 480 490 500 510 520 pF1KE6 WPLLFFEYEGNFIQKFQRELSTKWVLNTVSTGAHVLLGKILQNHMLDLRISNSKLFWRAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WPLLFFEYEGNFIQKFQRELSTKWVLNTVSTGAHVLLGKILQNHMLDLRISNSKLFWRAL 280 290 300 310 320 330 530 540 550 560 570 580 pF1KE6 AMLQRFSGQSKARCIESLLRAIHFPQPLSDDIRAAPISCHVQVAHEKEQVIPIALLSLLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AMLQRFSGQSKARCIESLLRAIHFPQPLSDDIRAAPISCHVQVAHEKEQVIPIALLSLLF 340 350 360 370 380 390 590 600 610 620 pF1KE6 RCSITEAQAHLAAAPSVCEAVRSALAGPGQKRTADPLEILEPDVQ ::::::::::::::::::::::::::::::::::::::::::::: XP_016 RCSITEAQAHLAAAPSVCEAVRSALAGPGQKRTADPLEILEPDVQ 400 410 420 430 >>XP_011531065 (OMIM: 600842,613463) PREDICTED: glucokin (333 aa) initn: 2071 init1: 2071 opt: 2071 Z-score: 2669.7 bits: 503.2 E(85289): 5.8e-142 Smith-Waterman score: 2071; 98.8% identity (99.4% similar) in 326 aa overlap (1-326:1-326) 10 20 30 40 50 60 pF1KE6 MPGTKRFQHVIETPEPGKWELSGYEAAVPITEKSNPLTQDLDKADAENIVRLLGQCDAEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPGTKRFQHVIETPEPGKWELSGYEAAVPITEKSNPLTQDLDKADAENIVRLLGQCDAEI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 FQEEGQALSTYQRLYSESILTTMVQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FQEEGQALSTYQRLYSESILTTMVQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 FNQLMKGLGQKPLYTYLIAGGDRSVVASREGTEDSALHGIEELKKVAAGKKRVIVIGISV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FNQLMKGLGQKPLYTYLIAGGDRSVVASREGTEDSALHGIEELKKVAAGKKRVIVIGISV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 GLSAPFVAGQMDCCMNNTAVFLPVLVGFNPVSMARNDPIEDWSSTFRQVAERMQKMQEKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLSAPFVAGQMDCCMNNTAVFLPVLVGFNPVSMARNDPIEDWSSTFRQVAERMQKMQEKQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 KAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKTVDQGIAASQRCLLEILRTFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKTVDQGIAASQRCLLEILRTFE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 RAHQVTYSQSPKIATLMKSVSTSLEKKGHVYLVGWQTLGIIAIMDGVECIHTFGADFRDV :::::::::::::::::::::: . . XP_011 RAHQVTYSQSPKIATLMKSVSTRFPRCPWLSHW 310 320 330 625 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 16:01:54 2016 done: Tue Nov 8 16:01:55 2016 Total Scan time: 9.850 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]