FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8529, 963 aa 1>>>pF1KB8529 963 - 963 aa - 963 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1156+/-0.000473; mu= 22.8016+/- 0.029 mean_var=78.2319+/-15.411, 0's: 0 Z-trim(109.6): 17 B-trim: 12 in 1/50 Lambda= 0.145005 statistics sampled from 17791 (17801) to 17791 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.568), E-opt: 0.2 (0.209), width: 16 Scan time: 10.080 The best scores are: opt bits E(85289) NP_004127 (OMIM: 147582) iron-responsive element-b ( 963) 6374 1344.2 0 NP_001307871 (OMIM: 147582) iron-responsive elemen ( 906) 6000 1266.0 0 NP_001307870 (OMIM: 147582) iron-responsive elemen ( 713) 4662 986.0 0 XP_011516190 (OMIM: 100880) PREDICTED: cytoplasmic ( 889) 3302 701.5 4.8e-201 NP_001265281 (OMIM: 100880) cytoplasmic aconitate ( 889) 3302 701.5 4.8e-201 NP_002188 (OMIM: 100880) cytoplasmic aconitate hyd ( 889) 3302 701.5 4.8e-201 XP_005251533 (OMIM: 100880) PREDICTED: cytoplasmic ( 889) 3302 701.5 4.8e-201 NP_001307872 (OMIM: 147582) iron-responsive elemen ( 343) 2297 490.9 4.6e-138 XP_016884301 (OMIM: 100850,614559,616289) PREDICTE ( 747) 325 78.7 1.3e-13 NP_001089 (OMIM: 100850,614559,616289) aconitate h ( 780) 325 78.7 1.3e-13 >>NP_004127 (OMIM: 147582) iron-responsive element-bindi (963 aa) initn: 6374 init1: 6374 opt: 6374 Z-score: 7203.1 bits: 1344.2 E(85289): 0 Smith-Waterman score: 6374; 100.0% identity (100.0% similar) in 963 aa overlap (1-963:1-963) 10 20 30 40 50 60 pF1KB8 MDAPKAGYAFEYLIETLNDSSHKKFFDVSKLGTKYDVLPYSIRVLLEAAVRNCDGFLMKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MDAPKAGYAFEYLIETLNDSSHKKFFDVSKLGTKYDVLPYSIRVLLEAAVRNCDGFLMKK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EDVMNILDWKTKQSNVEVPFFPARVLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVHPAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EDVMNILDWKTKQSNVEVPFFPARVLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVHPAC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 PTDLTVDHSLQIDFSKCAIQNAPNPGGGDLQKAGKLSPLKVQPKKLPCRGQTTCRGSCDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PTDLTVDHSLQIDFSKCAIQNAPNPGGGDLQKAGKLSPLKVQPKKLPCRGQTTCRGSCDS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 GELGRNSGTFSSQIENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSRVFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GELGRNSGTFSSQIENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSRVFK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 NVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDSVVGTDSHITMVNGLGILGWGVGGIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 NVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDSVVGTDSHITMVNGLGILGWGVGGIE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 TEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFGSGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFGSGV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 SQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKLFRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKLFRN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 DQNSSGEPEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGFQIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DQNSSGEPEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGFQIA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 AEKQKDIVSIHYEGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLRVKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 AEKQKDIVSIHYEGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLRVKP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 YIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCSTCVGNTAPLSDAVLNAVKQGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 YIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCSTCVGNTAPLSDAVLNAVKQGD 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 LVTCGILSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPLGTDPTGKNIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LVTCGILSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPLGTDPTGKNIY 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 LHDIWPSREEVHRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTYIRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LHDIWPSREEVHRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTYIRC 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB8 PSFFDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLTPRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PSFFDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLTPRE 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB8 FNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 FNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIP 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB8 LIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGENAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGENAD 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB8 SLGLSGRETFSLTFPEELSPGITLNIQTSTGKVFSVIASFEDDVEITLYKHGGLLNFVAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SLGLSGRETFSLTFPEELSPGITLNIQTSTGKVFSVIASFEDDVEITLYKHGGLLNFVAR 910 920 930 940 950 960 pF1KB8 KFS ::: NP_004 KFS >>NP_001307871 (OMIM: 147582) iron-responsive element-bi (906 aa) initn: 6000 init1: 6000 opt: 6000 Z-score: 6780.6 bits: 1266.0 E(85289): 0 Smith-Waterman score: 6000; 100.0% identity (100.0% similar) in 906 aa overlap (58-963:1-906) 30 40 50 60 70 80 pF1KB8 VSKLGTKYDVLPYSIRVLLEAAVRNCDGFLMKKEDVMNILDWKTKQSNVEVPFFPARVLL :::::::::::::::::::::::::::::: NP_001 MKKEDVMNILDWKTKQSNVEVPFFPARVLL 10 20 30 90 100 110 120 130 140 pF1KB8 QDFTGIPAMVDFAAMREAVKTLGGDPEKVHPACPTDLTVDHSLQIDFSKCAIQNAPNPGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QDFTGIPAMVDFAAMREAVKTLGGDPEKVHPACPTDLTVDHSLQIDFSKCAIQNAPNPGG 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB8 GDLQKAGKLSPLKVQPKKLPCRGQTTCRGSCDSGELGRNSGTFSSQIENTPILCPFHLQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDLQKAGKLSPLKVQPKKLPCRGQTTCRGSCDSGELGRNSGTFSSQIENTPILCPFHLQP 100 110 120 130 140 150 210 220 230 240 250 260 pF1KB8 VPEPETVLKNQEVEFGRNRERLQFFKWSSRVFKNVAVIPPGTGMAHQINLEYLSRVVFEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPEPETVLKNQEVEFGRNRERLQFFKWSSRVFKNVAVIPPGTGMAHQINLEYLSRVVFEE 160 170 180 190 200 210 270 280 290 300 310 320 pF1KB8 KDLLFPDSVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLTLPEVVGCELTGSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDLLFPDSVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLTLPEVVGCELTGSSN 220 230 240 250 260 270 330 340 350 360 370 380 pF1KB8 PFVTSIDVVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PFVTSIDVVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPV 280 290 300 310 320 330 390 400 410 420 430 440 pF1KB8 DNVTLKHLEHTGFSKAKLESMETYLKAVKLFRNDQNSSGEPEYSQVIQINLNSIVPSVSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DNVTLKHLEHTGFSKAKLESMETYLKAVKLFRNDQNSSGEPEYSQVIQINLNSIVPSVSG 340 350 360 370 380 390 450 460 470 480 490 500 pF1KB8 PKRPQDRVAVTDMKSDFQACLNEKVGFKGFQIAAEKQKDIVSIHYEGSEYKLSHGSVVIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PKRPQDRVAVTDMKSDFQACLNEKVGFKGFQIAAEKQKDIVSIHYEGSEYKLSHGSVVIA 400 410 420 430 440 450 510 520 530 540 550 560 pF1KB8 AVISCTNNCNPSVMLAAGLLAKKAVEAGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVISCTNNCNPSVMLAAGLLAKKAVEAGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLS 460 470 480 490 500 510 570 580 590 600 610 620 pF1KB8 KLGFEIVGYGCSTCVGNTAPLSDAVLNAVKQGDLVTCGILSGNKNFEGRLCDCVRANYLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLGFEIVGYGCSTCVGNTAPLSDAVLNAVKQGDLVTCGILSGNKNFEGRLCDCVRANYLA 520 530 540 550 560 570 630 640 650 660 670 680 pF1KB8 SPPLVVAYAIAGTVNIDFQTEPLGTDPTGKNIYLHDIWPSREEVHRVEEEHVILSMFKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPPLVVAYAIAGTVNIDFQTEPLGTDPTGKNIYLHDIWPSREEVHRVEEEHVILSMFKAL 580 590 600 610 620 630 690 700 710 720 730 740 pF1KB8 KDKIEMGNKRWNSLEAPDSVLFPWDLKSTYIRCPSFFDKLTKEPIALQAIENAHVLLYLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDKIEMGNKRWNSLEAPDSVLFPWDLKSTYIRCPSFFDKLTKEPIALQAIENAHVLLYLG 640 650 660 670 680 690 750 760 770 780 790 800 pF1KB8 DSVTTDHISPAGSIARNSAAAKYLTNRGLTPREFNSYGARRGNDAVMTRGTFANIKLFNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSVTTDHISPAGSIARNSAAAKYLTNRGLTPREFNSYGARRGNDAVMTRGTFANIKLFNK 700 710 720 730 740 750 810 820 830 840 850 860 pF1KB8 FIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGV 760 770 780 790 800 810 870 880 890 900 910 920 pF1KB8 KAVLAESYEKIHKDHLIGIGIAPLQFLPGENADSLGLSGRETFSLTFPEELSPGITLNIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KAVLAESYEKIHKDHLIGIGIAPLQFLPGENADSLGLSGRETFSLTFPEELSPGITLNIQ 820 830 840 850 860 870 930 940 950 960 pF1KB8 TSTGKVFSVIASFEDDVEITLYKHGGLLNFVARKFS :::::::::::::::::::::::::::::::::::: NP_001 TSTGKVFSVIASFEDDVEITLYKHGGLLNFVARKFS 880 890 900 >>NP_001307870 (OMIM: 147582) iron-responsive element-bi (713 aa) initn: 4662 init1: 4662 opt: 4662 Z-score: 5269.3 bits: 986.0 E(85289): 0 Smith-Waterman score: 4662; 100.0% identity (100.0% similar) in 713 aa overlap (251-963:1-713) 230 240 250 260 270 280 pF1KB8 EFGRNRERLQFFKWSSRVFKNVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDSVVGTD :::::::::::::::::::::::::::::: NP_001 MAHQINLEYLSRVVFEEKDLLFPDSVVGTD 10 20 30 290 300 310 320 330 340 pF1KB8 SHITMVNGLGILGWGVGGIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SHITMVNGLGILGWGVGGIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGIT 40 50 60 70 80 90 350 360 370 380 390 400 pF1KB8 KHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGF 100 110 120 130 140 150 410 420 430 440 450 460 pF1KB8 SKAKLESMETYLKAVKLFRNDQNSSGEPEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKAKLESMETYLKAVKLFRNDQNSSGEPEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDM 160 170 180 190 200 210 470 480 490 500 510 520 pF1KB8 KSDFQACLNEKVGFKGFQIAAEKQKDIVSIHYEGSEYKLSHGSVVIAAVISCTNNCNPSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSDFQACLNEKVGFKGFQIAAEKQKDIVSIHYEGSEYKLSHGSVVIAAVISCTNNCNPSV 220 230 240 250 260 270 530 540 550 560 570 580 pF1KB8 MLAAGLLAKKAVEAGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLAAGLLAKKAVEAGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCST 280 290 300 310 320 330 590 600 610 620 630 640 pF1KB8 CVGNTAPLSDAVLNAVKQGDLVTCGILSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CVGNTAPLSDAVLNAVKQGDLVTCGILSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGT 340 350 360 370 380 390 650 660 670 680 690 700 pF1KB8 VNIDFQTEPLGTDPTGKNIYLHDIWPSREEVHRVEEEHVILSMFKALKDKIEMGNKRWNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VNIDFQTEPLGTDPTGKNIYLHDIWPSREEVHRVEEEHVILSMFKALKDKIEMGNKRWNS 400 410 420 430 440 450 710 720 730 740 750 760 pF1KB8 LEAPDSVLFPWDLKSTYIRCPSFFDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEAPDSVLFPWDLKSTYIRCPSFFDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGS 460 470 480 490 500 510 770 780 790 800 810 820 pF1KB8 IARNSAAAKYLTNRGLTPREFNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IARNSAAAKYLTNRGLTPREFNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFP 520 530 540 550 560 570 830 840 850 860 870 880 pF1KB8 SGQTLDVFEAAELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGQTLDVFEAAELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHK 580 590 600 610 620 630 890 900 910 920 930 940 pF1KB8 DHLIGIGIAPLQFLPGENADSLGLSGRETFSLTFPEELSPGITLNIQTSTGKVFSVIASF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DHLIGIGIAPLQFLPGENADSLGLSGRETFSLTFPEELSPGITLNIQTSTGKVFSVIASF 640 650 660 670 680 690 950 960 pF1KB8 EDDVEITLYKHGGLLNFVARKFS ::::::::::::::::::::::: NP_001 EDDVEITLYKHGGLLNFVARKFS 700 710 >>XP_011516190 (OMIM: 100880) PREDICTED: cytoplasmic aco (889 aa) initn: 3673 init1: 3299 opt: 3302 Z-score: 3730.4 bits: 701.5 E(85289): 4.8e-201 Smith-Waterman score: 3715; 57.3% identity (81.1% similar) in 957 aa overlap (10-963:5-888) 10 20 30 40 50 pF1KB8 MDAPKAGYAFEYLIETLND-SSHKKFFDVSKL-GTKYDVLPYSIRVLLEAAVRNCDGFLM : .: : :. . ::::...:: ..: ::.:::::::::.:::: ::. XP_011 MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLV 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 KKEDVMNILDWK-TKQSNVEVPFFPARVLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVH ::.:. ::: :. :...:.:::: ::::.::::::.::.:::::::.::: :::::::.. XP_011 KKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKIN 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 PACPTDLTVDHSLQIDFSKCAIQNAPNPGGGDLQKAGKLSPLKVQPKKLPCRGQTTCRGS :.::.::..:::.:.::.. : XP_011 PVCPADLVIDHSIQVDFNRRA--------------------------------------- 120 130 180 190 200 210 220 230 pF1KB8 CDSGELGRNSGTFSSQIENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSR :: :: :::..:: :::::..:.::.:. XP_011 -DS------------------------LQ---------KNQDLEFERNRERFEFLKWGSQ 140 150 160 240 250 260 270 280 290 pF1KB8 VFKNVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDSVVGTDSHITMVNGLGILGWGVG .:.:. .::::.:. ::.:::::.::::.. .:::.:::::: ::..:::::::::: XP_011 AFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVG 170 180 190 200 210 220 300 310 320 330 340 350 pF1KB8 GIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFG :::.:::::: :.:..::.:.: .: :. .:.::: :.:: ::::::::::.:::::::: XP_011 GIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFG 230 240 250 260 270 280 360 370 380 390 400 410 pF1KB8 SGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKL ::.::::.::.::::::::::: .:::::.:.. .: .:: .. ::. .. ::.:: . XP_011 PGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGM 290 300 310 320 330 340 420 430 440 450 460 470 pF1KB8 FRNDQNSSGEPEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGF ::. .. : .:...::....:...:: ::::::::.:::.:::.::..::. : ::::: XP_011 FRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGF 350 360 370 380 390 400 480 490 500 510 520 530 pF1KB8 QIAAEKQKDIVSIHYEGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLR :.: :...: .. :...:. :.::::::::. ::::. ::::::.:::::::::.::: XP_011 QVAPEHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLN 410 420 430 440 450 460 540 550 560 570 580 590 pF1KB8 VKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCSTCVGNTAPLSDAVLNAVK : :::.::::::::.::.::. :::.::::.:::..::::: ::.::..:: . :..:. XP_011 VMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAIT 470 480 490 500 510 520 600 610 620 630 640 650 pF1KB8 QGDLVTCGILSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPLGTDPTGK :::::. :.::::.:::::. .:::::::::::.:::::::. :::. ::::.. :. XP_011 QGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQ 530 540 550 560 570 580 660 670 680 690 700 710 pF1KB8 NIYLHDIWPSREEVHRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTY ...:.::::.:.:.. ::...:: .::: . .::: :. ::.: .:.. :: :. :::: XP_011 QVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTY 590 600 610 620 630 640 720 730 740 750 760 770 pF1KB8 IRCPSFFDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLT :. : ::..:: . ..: .:.::: ::::::::::::::.::::: ::.:::::::: XP_011 IKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLT 650 660 670 680 690 700 780 790 800 810 820 830 pF1KB8 PREFNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKE ::::::::.::::::::.:::::::.:.:.:..: ::.:::.:::. ::::.::: ::. XP_011 PREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQA 710 720 730 740 750 760 840 850 860 870 880 890 pF1KB8 GIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGE :.:::.::::.::.:.:::::::::.:::.:::::::::.::...:.:.:. ::..:::: XP_011 GLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGE 770 780 790 800 810 820 900 910 920 930 940 950 pF1KB8 NADSLGLSGRETFSLTFPEELSPGITLNIQTSTGKVFSVIASFEDDVEITLYKHGGLLNF :::.:::.:.: ... .::.:.: . .... .:::.:... :. :::.: . .::.::. XP_011 NADALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNY 830 840 850 860 870 880 960 pF1KB8 VARKFS . ::.. XP_011 MIRKMAK >>NP_001265281 (OMIM: 100880) cytoplasmic aconitate hydr (889 aa) initn: 3673 init1: 3299 opt: 3302 Z-score: 3730.4 bits: 701.5 E(85289): 4.8e-201 Smith-Waterman score: 3715; 57.3% identity (81.1% similar) in 957 aa overlap (10-963:5-888) 10 20 30 40 50 pF1KB8 MDAPKAGYAFEYLIETLND-SSHKKFFDVSKL-GTKYDVLPYSIRVLLEAAVRNCDGFLM : .: : :. . ::::...:: ..: ::.:::::::::.:::: ::. NP_001 MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLV 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 KKEDVMNILDWK-TKQSNVEVPFFPARVLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVH ::.:. ::: :. :...:.:::: ::::.::::::.::.:::::::.::: :::::::.. NP_001 KKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKIN 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 PACPTDLTVDHSLQIDFSKCAIQNAPNPGGGDLQKAGKLSPLKVQPKKLPCRGQTTCRGS :.::.::..:::.:.::.. : NP_001 PVCPADLVIDHSIQVDFNRRA--------------------------------------- 120 130 180 190 200 210 220 230 pF1KB8 CDSGELGRNSGTFSSQIENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSR :: :: :::..:: :::::..:.::.:. NP_001 -DS------------------------LQ---------KNQDLEFERNRERFEFLKWGSQ 140 150 160 240 250 260 270 280 290 pF1KB8 VFKNVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDSVVGTDSHITMVNGLGILGWGVG .:.:. .::::.:. ::.:::::.::::.. .:::.:::::: ::..:::::::::: NP_001 AFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVG 170 180 190 200 210 220 300 310 320 330 340 350 pF1KB8 GIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFG :::.:::::: :.:..::.:.: .: :. .:.::: :.:: ::::::::::.:::::::: NP_001 GIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFG 230 240 250 260 270 280 360 370 380 390 400 410 pF1KB8 SGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKL ::.::::.::.::::::::::: .:::::.:.. .: .:: .. ::. .. ::.:: . NP_001 PGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGM 290 300 310 320 330 340 420 430 440 450 460 470 pF1KB8 FRNDQNSSGEPEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGF ::. .. : .:...::....:...:: ::::::::.:::.:::.::..::. : ::::: NP_001 FRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGF 350 360 370 380 390 400 480 490 500 510 520 530 pF1KB8 QIAAEKQKDIVSIHYEGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLR :.: :...: .. :...:. :.::::::::. ::::. ::::::.:::::::::.::: NP_001 QVAPEHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLN 410 420 430 440 450 460 540 550 560 570 580 590 pF1KB8 VKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCSTCVGNTAPLSDAVLNAVK : :::.::::::::.::.::. :::.::::.:::..::::: ::.::..:: . :..:. NP_001 VMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAIT 470 480 490 500 510 520 600 610 620 630 640 650 pF1KB8 QGDLVTCGILSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPLGTDPTGK :::::. :.::::.:::::. .:::::::::::.:::::::. :::. ::::.. :. NP_001 QGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQ 530 540 550 560 570 580 660 670 680 690 700 710 pF1KB8 NIYLHDIWPSREEVHRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTY ...:.::::.:.:.. ::...:: .::: . .::: :. ::.: .:.. :: :. :::: NP_001 QVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTY 590 600 610 620 630 640 720 730 740 750 760 770 pF1KB8 IRCPSFFDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLT :. : ::..:: . ..: .:.::: ::::::::::::::.::::: ::.:::::::: NP_001 IKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLT 650 660 670 680 690 700 780 790 800 810 820 830 pF1KB8 PREFNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKE ::::::::.::::::::.:::::::.:.:.:..: ::.:::.:::. ::::.::: ::. NP_001 PREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQA 710 720 730 740 750 760 840 850 860 870 880 890 pF1KB8 GIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGE :.:::.::::.::.:.:::::::::.:::.:::::::::.::...:.:.:. ::..:::: NP_001 GLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGE 770 780 790 800 810 820 900 910 920 930 940 950 pF1KB8 NADSLGLSGRETFSLTFPEELSPGITLNIQTSTGKVFSVIASFEDDVEITLYKHGGLLNF :::.:::.:.: ... .::.:.: . .... .:::.:... :. :::.: . .::.::. NP_001 NADALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNY 830 840 850 860 870 880 960 pF1KB8 VARKFS . ::.. NP_001 MIRKMAK >>NP_002188 (OMIM: 100880) cytoplasmic aconitate hydrata (889 aa) initn: 3673 init1: 3299 opt: 3302 Z-score: 3730.4 bits: 701.5 E(85289): 4.8e-201 Smith-Waterman score: 3715; 57.3% identity (81.1% similar) in 957 aa overlap (10-963:5-888) 10 20 30 40 50 pF1KB8 MDAPKAGYAFEYLIETLND-SSHKKFFDVSKL-GTKYDVLPYSIRVLLEAAVRNCDGFLM : .: : :. . ::::...:: ..: ::.:::::::::.:::: ::. NP_002 MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLV 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 KKEDVMNILDWK-TKQSNVEVPFFPARVLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVH ::.:. ::: :. :...:.:::: ::::.::::::.::.:::::::.::: :::::::.. NP_002 KKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKIN 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 PACPTDLTVDHSLQIDFSKCAIQNAPNPGGGDLQKAGKLSPLKVQPKKLPCRGQTTCRGS :.::.::..:::.:.::.. : NP_002 PVCPADLVIDHSIQVDFNRRA--------------------------------------- 120 130 180 190 200 210 220 230 pF1KB8 CDSGELGRNSGTFSSQIENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSR :: :: :::..:: :::::..:.::.:. NP_002 -DS------------------------LQ---------KNQDLEFERNRERFEFLKWGSQ 140 150 160 240 250 260 270 280 290 pF1KB8 VFKNVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDSVVGTDSHITMVNGLGILGWGVG .:.:. .::::.:. ::.:::::.::::.. .:::.:::::: ::..:::::::::: NP_002 AFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVG 170 180 190 200 210 220 300 310 320 330 340 350 pF1KB8 GIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFG :::.:::::: :.:..::.:.: .: :. .:.::: :.:: ::::::::::.:::::::: NP_002 GIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFG 230 240 250 260 270 280 360 370 380 390 400 410 pF1KB8 SGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKL ::.::::.::.::::::::::: .:::::.:.. .: .:: .. ::. .. ::.:: . NP_002 PGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGM 290 300 310 320 330 340 420 430 440 450 460 470 pF1KB8 FRNDQNSSGEPEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGF ::. .. : .:...::....:...:: ::::::::.:::.:::.::..::. : ::::: NP_002 FRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGF 350 360 370 380 390 400 480 490 500 510 520 530 pF1KB8 QIAAEKQKDIVSIHYEGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLR :.: :...: .. :...:. :.::::::::. ::::. ::::::.:::::::::.::: NP_002 QVAPEHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLN 410 420 430 440 450 460 540 550 560 570 580 590 pF1KB8 VKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCSTCVGNTAPLSDAVLNAVK : :::.::::::::.::.::. :::.::::.:::..::::: ::.::..:: . :..:. NP_002 VMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAIT 470 480 490 500 510 520 600 610 620 630 640 650 pF1KB8 QGDLVTCGILSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPLGTDPTGK :::::. :.::::.:::::. .:::::::::::.:::::::. :::. ::::.. :. NP_002 QGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQ 530 540 550 560 570 580 660 670 680 690 700 710 pF1KB8 NIYLHDIWPSREEVHRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTY ...:.::::.:.:.. ::...:: .::: . .::: :. ::.: .:.. :: :. :::: NP_002 QVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTY 590 600 610 620 630 640 720 730 740 750 760 770 pF1KB8 IRCPSFFDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLT :. : ::..:: . ..: .:.::: ::::::::::::::.::::: ::.:::::::: NP_002 IKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLT 650 660 670 680 690 700 780 790 800 810 820 830 pF1KB8 PREFNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKE ::::::::.::::::::.:::::::.:.:.:..: ::.:::.:::. ::::.::: ::. NP_002 PREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQA 710 720 730 740 750 760 840 850 860 870 880 890 pF1KB8 GIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGE :.:::.::::.::.:.:::::::::.:::.:::::::::.::...:.:.:. ::..:::: NP_002 GLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGE 770 780 790 800 810 820 900 910 920 930 940 950 pF1KB8 NADSLGLSGRETFSLTFPEELSPGITLNIQTSTGKVFSVIASFEDDVEITLYKHGGLLNF :::.:::.:.: ... .::.:.: . .... .:::.:... :. :::.: . .::.::. NP_002 NADALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNY 830 840 850 860 870 880 960 pF1KB8 VARKFS . ::.. NP_002 MIRKMAK >>XP_005251533 (OMIM: 100880) PREDICTED: cytoplasmic aco (889 aa) initn: 3673 init1: 3299 opt: 3302 Z-score: 3730.4 bits: 701.5 E(85289): 4.8e-201 Smith-Waterman score: 3715; 57.3% identity (81.1% similar) in 957 aa overlap (10-963:5-888) 10 20 30 40 50 pF1KB8 MDAPKAGYAFEYLIETLND-SSHKKFFDVSKL-GTKYDVLPYSIRVLLEAAVRNCDGFLM : .: : :. . ::::...:: ..: ::.:::::::::.:::: ::. XP_005 MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLV 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 KKEDVMNILDWK-TKQSNVEVPFFPARVLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVH ::.:. ::: :. :...:.:::: ::::.::::::.::.:::::::.::: :::::::.. XP_005 KKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKIN 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 PACPTDLTVDHSLQIDFSKCAIQNAPNPGGGDLQKAGKLSPLKVQPKKLPCRGQTTCRGS :.::.::..:::.:.::.. : XP_005 PVCPADLVIDHSIQVDFNRRA--------------------------------------- 120 130 180 190 200 210 220 230 pF1KB8 CDSGELGRNSGTFSSQIENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSR :: :: :::..:: :::::..:.::.:. XP_005 -DS------------------------LQ---------KNQDLEFERNRERFEFLKWGSQ 140 150 160 240 250 260 270 280 290 pF1KB8 VFKNVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDSVVGTDSHITMVNGLGILGWGVG .:.:. .::::.:. ::.:::::.::::.. .:::.:::::: ::..:::::::::: XP_005 AFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVG 170 180 190 200 210 220 300 310 320 330 340 350 pF1KB8 GIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFG :::.:::::: :.:..::.:.: .: :. .:.::: :.:: ::::::::::.:::::::: XP_005 GIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFG 230 240 250 260 270 280 360 370 380 390 400 410 pF1KB8 SGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKL ::.::::.::.::::::::::: .:::::.:.. .: .:: .. ::. .. ::.:: . XP_005 PGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGM 290 300 310 320 330 340 420 430 440 450 460 470 pF1KB8 FRNDQNSSGEPEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGF ::. .. : .:...::....:...:: ::::::::.:::.:::.::..::. : ::::: XP_005 FRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGF 350 360 370 380 390 400 480 490 500 510 520 530 pF1KB8 QIAAEKQKDIVSIHYEGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLR :.: :...: .. :...:. :.::::::::. ::::. ::::::.:::::::::.::: XP_005 QVAPEHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLN 410 420 430 440 450 460 540 550 560 570 580 590 pF1KB8 VKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCSTCVGNTAPLSDAVLNAVK : :::.::::::::.::.::. :::.::::.:::..::::: ::.::..:: . :..:. XP_005 VMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAIT 470 480 490 500 510 520 600 610 620 630 640 650 pF1KB8 QGDLVTCGILSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPLGTDPTGK :::::. :.::::.:::::. .:::::::::::.:::::::. :::. ::::.. :. XP_005 QGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQ 530 540 550 560 570 580 660 670 680 690 700 710 pF1KB8 NIYLHDIWPSREEVHRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTY ...:.::::.:.:.. ::...:: .::: . .::: :. ::.: .:.. :: :. :::: XP_005 QVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTY 590 600 610 620 630 640 720 730 740 750 760 770 pF1KB8 IRCPSFFDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLT :. : ::..:: . ..: .:.::: ::::::::::::::.::::: ::.:::::::: XP_005 IKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLT 650 660 670 680 690 700 780 790 800 810 820 830 pF1KB8 PREFNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKE ::::::::.::::::::.:::::::.:.:.:..: ::.:::.:::. ::::.::: ::. XP_005 PREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQA 710 720 730 740 750 760 840 850 860 870 880 890 pF1KB8 GIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGE :.:::.::::.::.:.:::::::::.:::.:::::::::.::...:.:.:. ::..:::: XP_005 GLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGE 770 780 790 800 810 820 900 910 920 930 940 950 pF1KB8 NADSLGLSGRETFSLTFPEELSPGITLNIQTSTGKVFSVIASFEDDVEITLYKHGGLLNF :::.:::.:.: ... .::.:.: . .... .:::.:... :. :::.: . .::.::. XP_005 NADALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNY 830 840 850 860 870 880 960 pF1KB8 VARKFS . ::.. XP_005 MIRKMAK >>NP_001307872 (OMIM: 147582) iron-responsive element-bi (343 aa) initn: 2297 init1: 2297 opt: 2297 Z-score: 2599.7 bits: 490.9 E(85289): 4.6e-138 Smith-Waterman score: 2297; 100.0% identity (100.0% similar) in 341 aa overlap (1-341:1-341) 10 20 30 40 50 60 pF1KB8 MDAPKAGYAFEYLIETLNDSSHKKFFDVSKLGTKYDVLPYSIRVLLEAAVRNCDGFLMKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDAPKAGYAFEYLIETLNDSSHKKFFDVSKLGTKYDVLPYSIRVLLEAAVRNCDGFLMKK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EDVMNILDWKTKQSNVEVPFFPARVLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVHPAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDVMNILDWKTKQSNVEVPFFPARVLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVHPAC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 PTDLTVDHSLQIDFSKCAIQNAPNPGGGDLQKAGKLSPLKVQPKKLPCRGQTTCRGSCDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTDLTVDHSLQIDFSKCAIQNAPNPGGGDLQKAGKLSPLKVQPKKLPCRGQTTCRGSCDS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 GELGRNSGTFSSQIENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSRVFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GELGRNSGTFSSQIENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSRVFK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 NVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDSVVGTDSHITMVNGLGILGWGVGGIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDSVVGTDSHITMVNGLGILGWGVGGIE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 TEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFGSGV ::::::::::::::::::::::::::::::::::::::::: NP_001 TEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGITKVS 310 320 330 340 370 380 390 400 410 420 pF1KB8 SQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKLFRN >>XP_016884301 (OMIM: 100850,614559,616289) PREDICTED: a (747 aa) initn: 540 init1: 283 opt: 325 Z-score: 365.6 bits: 78.7 E(85289): 1.3e-13 Smith-Waterman score: 624; 27.3% identity (52.4% similar) in 740 aa overlap (225-956:114-740) 200 210 220 230 240 250 pF1KB8 ENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSRVFKNVAVIPPGTGMAHQ :.: .:. .. . .:. ::.:. :: XP_016 KVAVPSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKY-GVGFWKPGSGIIHQ 90 100 110 120 130 140 260 270 280 290 300 310 pF1KB8 INLEYLSRVVFEEKDLLFPDSV-VGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLT : :: . .: . .::::: .::: . :::: .. :: :.: : XP_016 IILE----------NYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELK 150 160 170 180 190 320 330 340 350 360 370 pF1KB8 LPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIAN :.:.: .:::: . . . ::.: .. : : .: .::. : ::...: . .:: : XP_016 CPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICN 200 210 220 230 240 250 380 390 400 410 420 430 pF1KB8 MCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKLFRNDQNSSGEPEYSQV : : :: : :: .. :.: .:: : . . :.. . .:.:. XP_016 MGAEIGATTSVFPYNHRMKKYLSKTG--------REDIANLADEFKDHLVPDPGCHYDQL 260 270 280 290 300 440 450 460 470 480 490 pF1KB8 IQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGFQIAAEKQKDIVSIHYE :.:::. . : ..:: : :. . : :: .::: : XP_016 IEINLSELKPHINGPFTP-----------DLAHPVAE-VG-----KVAEK---------E 310 320 330 500 510 520 530 540 550 pF1KB8 GSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLRVKPYIRTSLSPGSGMV : . :. . .. . ::::. .. .:.. ::.:. ::. : . ...::: .. XP_016 G--WPLD---IRVGLIGSCTNSSYEDMGRSAAV-AKQALAHGLKCKSQF--TITPGSEQI 340 350 360 370 380 390 560 570 580 590 600 610 pF1KB8 THYLSSSGVLPYLSKLGFEIVGYGCSTCVGNTAPLSDAVLNAVKQGDLVTCGILSGNKNF . .: : :: ... .:. :.:. .: .:.:. : . : :.:: XP_016 RATIERDGYAQILRDLGGIVLANACGPCIGQW-DRKD-----IKKGEKNTI-VTSYNRNF 400 410 420 430 440 620 630 640 650 660 670 pF1KB8 EGRLCDCVRAN-YLASPPLVVAYAIAGTVNIDFQTEPL-GTDPTGKNIYLHDIWPSREEV :: ... ...:: .:.: :::::.... .:. : ::: ::.. :. :. .:. XP_016 TGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTD--GKKFRLEA--PDADEL 450 460 470 480 490 680 690 700 710 720 pF1KB8 HRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTYIRCPSF--FDKLTK . : : .: . : :: :.. : : . ::: XP_016 PKGE--------FDPGQDTYQHPPK--------DSSGQHVDVSPTSQRLQLLEPFDKWDG 500 510 520 530 540 730 740 750 760 770 780 pF1KB8 EPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLTPREFNSYGARRG . . :. ..:. . . :::::: :: .: :: XP_016 KDL-----EDLQILIKVKGKCTTDHISAAGP---------WLKFRGHL------------ 550 560 570 790 800 810 820 830 840 pF1KB8 NDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKY : . . .. :.. : :: : .. . . . : ..:. :.:.:: .... ..: XP_016 -DNISNNLLIGAINIEN---GK-ANSVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDENY 580 590 600 610 620 630 850 860 870 880 890 900 pF1KB8 GSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGENADSLGLSGRET : :.::. :: : :: .:....:. .::. .: :. :: : .. :: . . XP_016 GEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTF--ADPADYNKIHPVDK 640 650 660 670 680 690 910 920 930 940 950 960 pF1KB8 FSLTFPEELSPGITLN--IQTSTGKVFSVIASFE-DDVEITLYKHGGLLNFVARKFS ... ....:: :. :. .: ... . ....: .. :. :: XP_016 LTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ 700 710 720 730 740 >>NP_001089 (OMIM: 100850,614559,616289) aconitate hydra (780 aa) initn: 540 init1: 283 opt: 325 Z-score: 365.4 bits: 78.7 E(85289): 1.3e-13 Smith-Waterman score: 624; 27.3% identity (52.4% similar) in 740 aa overlap (225-956:147-773) 200 210 220 230 240 250 pF1KB8 ENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSRVFKNVAVIPPGTGMAHQ :.: .:. .. . .:. ::.:. :: NP_001 KVAVPSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKY-GVGFWKPGSGIIHQ 120 130 140 150 160 170 260 270 280 290 300 310 pF1KB8 INLEYLSRVVFEEKDLLFPDSV-VGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLT : :: . .: . .::::: .::: . :::: .. :: :.: : NP_001 IILE----------NYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELK 180 190 200 210 220 320 330 340 350 360 370 pF1KB8 LPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIAN :.:.: .:::: . . . ::.: .. : : .: .::. : ::...: . .:: : NP_001 CPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICN 230 240 250 260 270 280 380 390 400 410 420 430 pF1KB8 MCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKLFRNDQNSSGEPEYSQV : : :: : :: .. :.: .:: : . . :.. . .:.:. NP_001 MGAEIGATTSVFPYNHRMKKYLSKTG--------REDIANLADEFKDHLVPDPGCHYDQL 290 300 310 320 330 440 450 460 470 480 490 pF1KB8 IQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGFQIAAEKQKDIVSIHYE :.:::. . : ..:: : :. . : :: .::: : NP_001 IEINLSELKPHINGPFTP-----------DLAHPVAE-VG-----KVAEK---------E 340 350 360 370 500 510 520 530 540 550 pF1KB8 GSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLRVKPYIRTSLSPGSGMV : . :. . .. . ::::. .. .:.. ::.:. ::. : . ...::: .. NP_001 G--WPLD---IRVGLIGSCTNSSYEDMGRSAAV-AKQALAHGLKCKSQF--TITPGSEQI 380 390 400 410 420 560 570 580 590 600 610 pF1KB8 THYLSSSGVLPYLSKLGFEIVGYGCSTCVGNTAPLSDAVLNAVKQGDLVTCGILSGNKNF . .: : :: ... .:. :.:. .: .:.:. : . : :.:: NP_001 RATIERDGYAQILRDLGGIVLANACGPCIGQW-DRKD-----IKKGEKNTI-VTSYNRNF 430 440 450 460 470 620 630 640 650 660 670 pF1KB8 EGRLCDCVRAN-YLASPPLVVAYAIAGTVNIDFQTEPL-GTDPTGKNIYLHDIWPSREEV :: ... ...:: .:.: :::::.... .:. : ::: ::.. :. :. .:. NP_001 TGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTD--GKKFRLEA--PDADEL 480 490 500 510 520 530 680 690 700 710 720 pF1KB8 HRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTYIRCPSF--FDKLTK . : : .: . : :: :.. : : . ::: NP_001 PKGE--------FDPGQDTYQHPPK--------DSSGQHVDVSPTSQRLQLLEPFDKWDG 540 550 560 570 730 740 750 760 770 780 pF1KB8 EPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLTPREFNSYGARRG . . :. ..:. . . :::::: :: .: :: NP_001 KDL-----EDLQILIKVKGKCTTDHISAAGP---------WLKFRGHL------------ 580 590 600 610 790 800 810 820 830 840 pF1KB8 NDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKY : . . .. :.. : :: : .. . . . : ..:. :.:.:: .... ..: NP_001 -DNISNNLLIGAINIEN---GK-ANSVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDENY 620 630 640 650 660 850 860 870 880 890 900 pF1KB8 GSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGENADSLGLSGRET : :.::. :: : :: .:....:. .::. .: :. :: : .. :: . . NP_001 GEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTF--ADPADYNKIHPVDK 670 680 690 700 710 720 910 920 930 940 950 960 pF1KB8 FSLTFPEELSPGITLN--IQTSTGKVFSVIASFE-DDVEITLYKHGGLLNFVARKFS ... ....:: :. :. .: ... . ....: .. :. :: NP_001 LTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ 730 740 750 760 770 780 963 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 06:13:11 2016 done: Tue Nov 8 06:13:12 2016 Total Scan time: 10.080 Total Display time: 0.230 Function used was FASTA [36.3.4 Apr, 2011]