FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6162, 172 aa 1>>>pF1KE6162 172 - 172 aa - 172 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4897+/-0.000247; mu= 13.8147+/- 0.016 mean_var=90.0283+/-17.713, 0's: 0 Z-trim(123.3): 12 B-trim: 0 in 0/55 Lambda= 0.135171 statistics sampled from 42979 (42991) to 42979 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.833), E-opt: 0.2 (0.504), width: 16 Scan time: 4.390 The best scores are: opt bits E(85289) NP_848932 (OMIM: 607398,609196) melanocortin-2 rec ( 172) 1194 241.3 5.8e-64 XP_006724091 (OMIM: 607398,609196) PREDICTED: mela ( 172) 1194 241.3 5.8e-64 NP_001272323 (OMIM: 607398,609196) melanocortin-2 ( 113) 815 167.2 7.5e-42 NP_996781 (OMIM: 607398,609196) melanocortin-2 rec ( 102) 448 95.6 2.4e-20 XP_016883896 (OMIM: 607398,609196) PREDICTED: mela ( 102) 448 95.6 2.4e-20 XP_016865709 (OMIM: 615410,615457) PREDICTED: mela ( 205) 189 45.4 6.5e-05 NP_612418 (OMIM: 615410,615457) melanocortin-2 rec ( 205) 189 45.4 6.5e-05 NP_001333471 (OMIM: 615410,615457) melanocortin-2 ( 205) 189 45.4 6.5e-05 NP_001333473 (OMIM: 615410,615457) melanocortin-2 ( 205) 189 45.4 6.5e-05 XP_016865710 (OMIM: 615410,615457) PREDICTED: mela ( 154) 185 44.5 9e-05 >>NP_848932 (OMIM: 607398,609196) melanocortin-2 recepto (172 aa) initn: 1194 init1: 1194 opt: 1194 Z-score: 1269.4 bits: 241.3 E(85289): 5.8e-64 Smith-Waterman score: 1194; 100.0% identity (100.0% similar) in 172 aa overlap (1-172:1-172) 10 20 30 40 50 60 pF1KE6 MANGTNASAPYYSYEYYLDYLDLIPVDEKKLKAHKHSIVIAFWVSLAAFVVLLFLILLYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_848 MANGTNASAPYYSYEYYLDYLDLIPVDEKKLKAHKHSIVIAFWVSLAAFVVLLFLILLYM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 SWSASPQMRNSPKHHQTCPWSHGLNLHLCIQKCLPCHREPLATSQAQASSVEPGSRTGPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_848 SWSASPQMRNSPKHHQTCPWSHGLNLHLCIQKCLPCHREPLATSQAQASSVEPGSRTGPD 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 QPLRQESSSTLPLGGFQTHPTLLWELTLNGGPLVRSKPSEPPPGDRTSQLQS :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_848 QPLRQESSSTLPLGGFQTHPTLLWELTLNGGPLVRSKPSEPPPGDRTSQLQS 130 140 150 160 170 >>XP_006724091 (OMIM: 607398,609196) PREDICTED: melanoco (172 aa) initn: 1194 init1: 1194 opt: 1194 Z-score: 1269.4 bits: 241.3 E(85289): 5.8e-64 Smith-Waterman score: 1194; 100.0% identity (100.0% similar) in 172 aa overlap (1-172:1-172) 10 20 30 40 50 60 pF1KE6 MANGTNASAPYYSYEYYLDYLDLIPVDEKKLKAHKHSIVIAFWVSLAAFVVLLFLILLYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MANGTNASAPYYSYEYYLDYLDLIPVDEKKLKAHKHSIVIAFWVSLAAFVVLLFLILLYM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 SWSASPQMRNSPKHHQTCPWSHGLNLHLCIQKCLPCHREPLATSQAQASSVEPGSRTGPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SWSASPQMRNSPKHHQTCPWSHGLNLHLCIQKCLPCHREPLATSQAQASSVEPGSRTGPD 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 QPLRQESSSTLPLGGFQTHPTLLWELTLNGGPLVRSKPSEPPPGDRTSQLQS :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QPLRQESSSTLPLGGFQTHPTLLWELTLNGGPLVRSKPSEPPPGDRTSQLQS 130 140 150 160 170 >>NP_001272323 (OMIM: 607398,609196) melanocortin-2 rece (113 aa) initn: 815 init1: 815 opt: 815 Z-score: 872.4 bits: 167.2 E(85289): 7.5e-42 Smith-Waterman score: 815; 100.0% identity (100.0% similar) in 113 aa overlap (60-172:1-113) 30 40 50 60 70 80 pF1KE6 KLKAHKHSIVIAFWVSLAAFVVLLFLILLYMSWSASPQMRNSPKHHQTCPWSHGLNLHLC :::::::::::::::::::::::::::::: NP_001 MSWSASPQMRNSPKHHQTCPWSHGLNLHLC 10 20 30 90 100 110 120 130 140 pF1KE6 IQKCLPCHREPLATSQAQASSVEPGSRTGPDQPLRQESSSTLPLGGFQTHPTLLWELTLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IQKCLPCHREPLATSQAQASSVEPGSRTGPDQPLRQESSSTLPLGGFQTHPTLLWELTLN 40 50 60 70 80 90 150 160 170 pF1KE6 GGPLVRSKPSEPPPGDRTSQLQS ::::::::::::::::::::::: NP_001 GGPLVRSKPSEPPPGDRTSQLQS 100 110 >>NP_996781 (OMIM: 607398,609196) melanocortin-2 recepto (102 aa) initn: 445 init1: 445 opt: 448 Z-score: 486.2 bits: 95.6 E(85289): 2.4e-20 Smith-Waterman score: 448; 79.8% identity (89.9% similar) in 89 aa overlap (1-85:1-89) 10 20 30 40 50 60 pF1KE6 MANGTNASAPYYSYEYYLDYLDLIPVDEKKLKAHKHSIVIAFWVSLAAFVVLLFLILLYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 MANGTNASAPYYSYEYYLDYLDLIPVDEKKLKAHKHSIVIAFWVSLAAFVVLLFLILLYM 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 SWSASPQMR-NSPK---HHQTCPWSHGLNLHLCIQKCLPCHREPLATSQAQASSVEPGSR :::::::: :. . : .. : ..... NP_996 SWSASPQMSFNTDESLLHSEVLPQTRAISCDELQAPREEGAA 70 80 90 100 >>XP_016883896 (OMIM: 607398,609196) PREDICTED: melanoco (102 aa) initn: 445 init1: 445 opt: 448 Z-score: 486.2 bits: 95.6 E(85289): 2.4e-20 Smith-Waterman score: 448; 79.8% identity (89.9% similar) in 89 aa overlap (1-85:1-89) 10 20 30 40 50 60 pF1KE6 MANGTNASAPYYSYEYYLDYLDLIPVDEKKLKAHKHSIVIAFWVSLAAFVVLLFLILLYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MANGTNASAPYYSYEYYLDYLDLIPVDEKKLKAHKHSIVIAFWVSLAAFVVLLFLILLYM 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 SWSASPQMR-NSPK---HHQTCPWSHGLNLHLCIQKCLPCHREPLATSQAQASSVEPGSR :::::::: :. . : .. : ..... XP_016 SWSASPQMSFNTDESLLHSEVLPQTRAISCDELQAPREEGAA 70 80 90 100 >>XP_016865709 (OMIM: 615410,615457) PREDICTED: melanoco (205 aa) initn: 216 init1: 182 opt: 189 Z-score: 209.2 bits: 45.4 E(85289): 6.5e-05 Smith-Waterman score: 189; 42.4% identity (80.3% similar) in 66 aa overlap (6-71:15-78) 10 20 30 40 50 pF1KE6 MANGTNASAPYYSYEYYLDYLDLIPVDEKKLKAHKHSIVIAFWVSLAAFVV .:: :..:: .: .. ::. . :::::.::::.:::.::.::. XP_016 MSAQRLISNRTSQQSASNSDYTWEY--EYYEIGPVSFEGLKAHKYSIVIGFWVGLAVFVI 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 LLFLILLYMSWSASPQMRNSPKHHQTCPWSHGLNLHLCIQKCLPCHREPLATSQAQASSV ..:..: .. ...:.. :. XP_016 FMFFVLTLLTKTGAPHQDNAESSEKRFRMNSFVSDFGRPLEPDKVFSRQGNEESRSLFHC 60 70 80 90 100 110 >>NP_612418 (OMIM: 615410,615457) melanocortin-2 recepto (205 aa) initn: 216 init1: 182 opt: 189 Z-score: 209.2 bits: 45.4 E(85289): 6.5e-05 Smith-Waterman score: 189; 42.4% identity (80.3% similar) in 66 aa overlap (6-71:15-78) 10 20 30 40 50 pF1KE6 MANGTNASAPYYSYEYYLDYLDLIPVDEKKLKAHKHSIVIAFWVSLAAFVV .:: :..:: .: .. ::. . :::::.::::.:::.::.::. NP_612 MSAQRLISNRTSQQSASNSDYTWEY--EYYEIGPVSFEGLKAHKYSIVIGFWVGLAVFVI 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 LLFLILLYMSWSASPQMRNSPKHHQTCPWSHGLNLHLCIQKCLPCHREPLATSQAQASSV ..:..: .. ...:.. :. NP_612 FMFFVLTLLTKTGAPHQDNAESSEKRFRMNSFVSDFGRPLEPDKVFSRQGNEESRSLFHC 60 70 80 90 100 110 >>NP_001333471 (OMIM: 615410,615457) melanocortin-2 rece (205 aa) initn: 216 init1: 182 opt: 189 Z-score: 209.2 bits: 45.4 E(85289): 6.5e-05 Smith-Waterman score: 189; 42.4% identity (80.3% similar) in 66 aa overlap (6-71:15-78) 10 20 30 40 50 pF1KE6 MANGTNASAPYYSYEYYLDYLDLIPVDEKKLKAHKHSIVIAFWVSLAAFVV .:: :..:: .: .. ::. . :::::.::::.:::.::.::. NP_001 MSAQRLISNRTSQQSASNSDYTWEY--EYYEIGPVSFEGLKAHKYSIVIGFWVGLAVFVI 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 LLFLILLYMSWSASPQMRNSPKHHQTCPWSHGLNLHLCIQKCLPCHREPLATSQAQASSV ..:..: .. ...:.. :. NP_001 FMFFVLTLLTKTGAPHQDNAESSEKRFRMNSFVSDFGRPLEPDKVFSRQGNEESRSLFHC 60 70 80 90 100 110 >>NP_001333473 (OMIM: 615410,615457) melanocortin-2 rece (205 aa) initn: 216 init1: 182 opt: 189 Z-score: 209.2 bits: 45.4 E(85289): 6.5e-05 Smith-Waterman score: 189; 42.4% identity (80.3% similar) in 66 aa overlap (6-71:15-78) 10 20 30 40 50 pF1KE6 MANGTNASAPYYSYEYYLDYLDLIPVDEKKLKAHKHSIVIAFWVSLAAFVV .:: :..:: .: .. ::. . :::::.::::.:::.::.::. NP_001 MSAQRLISNRTSQQSASNSDYTWEY--EYYEIGPVSFEGLKAHKYSIVIGFWVGLAVFVI 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 LLFLILLYMSWSASPQMRNSPKHHQTCPWSHGLNLHLCIQKCLPCHREPLATSQAQASSV ..:..: .. ...:.. :. NP_001 FMFFVLTLLTKTGAPHQDNAESSEKRFRMNSFVSDFGRPLEPDKVFSRQGNEESRSLFHC 60 70 80 90 100 110 >>XP_016865710 (OMIM: 615410,615457) PREDICTED: melanoco (154 aa) initn: 194 init1: 176 opt: 185 Z-score: 206.6 bits: 44.5 E(85289): 9e-05 Smith-Waterman score: 185; 37.0% identity (74.1% similar) in 81 aa overlap (6-86:15-91) 10 20 30 40 50 pF1KE6 MANGTNASAPYYSYEYYLDYLDLIPVDEKKLKAHKHSIVIAFWVSLAAFVV .:: :..:: .: .. ::. . :::::.::::.:::.::.::. XP_016 MSAQRLISNRTSQQSASNSDYTWEY--EYYEIGPVSFEGLKAHKYSIVIGFWVGLAVFVI 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 LLFLILLYMSWSASPQMRNSPKHHQTCPWSHGLNLHLCIQKCLPCHREPLATSQAQASSV ..:..: .. ...:.. . ... : : . :. XP_016 FMFFVLTLLTKTGAPHQDGLSQQELT--WVEKKNFSFLTVFGNADGTFWDTPSTLEPADE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 EPGSRTGPDQPLRQESSSTLPLGGFQTHPTLLWELTLNGGPLVRSKPSEPPPGDRTSQLQ XP_016 ILAKLAEAGKRKIHGKHSDKYRLLITSRSYHLARNASY 120 130 140 150 172 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 09:58:46 2016 done: Tue Nov 8 09:58:47 2016 Total Scan time: 4.390 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]