Result of FASTA (omim) for
pFN21AE4414
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4414, 427 aa
1>>>pF1KE4414 427 - 427 aa - 427 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3975+/-0.00036; mu= 18.3722+/- 0.022
mean_var=94.1648+/-19.576, 0's: 0 Z-trim(114.8): 103 B-trim: 624 in 1/54
Lambda= 0.132169
statistics sampled from 24761 (24875) to 24761 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.651), E-opt: 0.2 (0.292), width: 16
Scan time: 8.530
The best scores are: opt bits E(85289)
NP_002241 (OMIM: 602754,616689) intermediate condu ( 427) 2835 550.9 2.2e-156
XP_005258939 (OMIM: 602754,616689) PREDICTED: inte ( 395) 2273 443.7 3.8e-124
XP_011525240 (OMIM: 602754,616689) PREDICTED: inte ( 259) 1547 305.1 1.3e-82
XP_005258940 (OMIM: 602754,616689) PREDICTED: inte ( 364) 1306 259.3 1.2e-68
NP_002240 (OMIM: 602983) small conductance calcium ( 731) 1154 230.6 1e-59
XP_005259964 (OMIM: 602982) PREDICTED: small condu ( 623) 1136 227.1 9.7e-59
XP_011526306 (OMIM: 602982) PREDICTED: small condu ( 626) 1136 227.1 9.7e-59
NP_067627 (OMIM: 605879) small conductance calcium ( 579) 1131 226.1 1.8e-58
XP_011541691 (OMIM: 605879) PREDICTED: small condu ( 857) 1131 226.3 2.4e-58
XP_011541689 (OMIM: 605879) PREDICTED: small condu ( 857) 1131 226.3 2.4e-58
NP_002239 (OMIM: 602982) small conductance calcium ( 543) 1120 224.0 7.3e-58
XP_011526307 (OMIM: 602982) PREDICTED: small condu ( 546) 1120 224.0 7.3e-58
XP_005259963 (OMIM: 602982) PREDICTED: small condu ( 626) 1120 224.1 8.1e-58
XP_005259962 (OMIM: 602982) PREDICTED: small condu ( 629) 1120 224.1 8.1e-58
NP_740752 (OMIM: 602983) small conductance calcium ( 426) 1080 216.3 1.2e-55
NP_001191016 (OMIM: 602983) small conductance calc ( 746) 654 135.3 5.1e-31
XP_016864946 (OMIM: 605879) PREDICTED: small condu ( 275) 620 128.4 2.2e-29
NP_740721 (OMIM: 605879) small conductance calcium ( 231) 615 127.4 3.8e-29
NP_001265133 (OMIM: 605879) small conductance calc ( 231) 615 127.4 3.8e-29
NP_861463 (OMIM: 130650,192500,220400,607542,60755 ( 549) 178 44.4 0.00086
NP_000209 (OMIM: 130650,192500,220400,607542,60755 ( 676) 178 44.5 0.001
XP_011515328 (OMIM: 121201,602232) PREDICTED: pota ( 752) 178 44.5 0.0011
NP_751895 (OMIM: 600101,603537) potassium voltage- ( 641) 173 43.5 0.0019
NP_004691 (OMIM: 600101,603537) potassium voltage- ( 695) 173 43.5 0.002
NP_742107 (OMIM: 121200,602235,613720) potassium v ( 393) 168 42.3 0.0026
NP_065748 (OMIM: 602906) potassium voltage-gated c ( 477) 165 41.9 0.0044
XP_016869471 (OMIM: 607738) PREDICTED: potassium v ( 666) 166 42.2 0.0048
XP_016869470 (OMIM: 607738) PREDICTED: potassium v ( 666) 166 42.2 0.0048
NP_001191753 (OMIM: 121201,602232) potassium volta ( 752) 166 42.2 0.0053
XP_016868889 (OMIM: 121201,602232) PREDICTED: pota ( 798) 166 42.3 0.0055
NP_004510 (OMIM: 121201,602232) potassium voltage- ( 872) 166 42.3 0.0059
NP_004761 (OMIM: 607738) potassium voltage-gated c ( 911) 166 42.3 0.0061
NP_004509 (OMIM: 121200,602235,613720) potassium v ( 844) 165 42.1 0.0065
XP_016866547 (OMIM: 607357) PREDICTED: potassium v ( 496) 162 41.3 0.0067
XP_011527113 (OMIM: 121200,602235,613720) PREDICTE ( 880) 165 42.1 0.0067
NP_001153606 (OMIM: 607357) potassium voltage-gate ( 822) 164 41.9 0.0073
NP_742106 (OMIM: 121200,602235,613720) potassium v ( 841) 163 41.7 0.0085
XP_016883333 (OMIM: 121200,602235,613720) PREDICTE ( 853) 163 41.7 0.0086
NP_742104 (OMIM: 121200,602235,613720) potassium v ( 854) 163 41.7 0.0086
XP_016883332 (OMIM: 121200,602235,613720) PREDICTE ( 867) 163 41.7 0.0087
XP_016883331 (OMIM: 121200,602235,613720) PREDICTE ( 868) 163 41.7 0.0087
NP_742105 (OMIM: 121200,602235,613720) potassium v ( 872) 163 41.7 0.0087
XP_016883330 (OMIM: 121200,602235,613720) PREDICTE ( 889) 163 41.7 0.0089
XP_011527112 (OMIM: 121200,602235,613720) PREDICTE ( 890) 163 41.7 0.0089
>>NP_002241 (OMIM: 602754,616689) intermediate conductan (427 aa)
initn: 2835 init1: 2835 opt: 2835 Z-score: 2928.5 bits: 550.9 E(85289): 2.2e-156
Smith-Waterman score: 2835; 99.8% identity (100.0% similar) in 427 aa overlap (1-427:1-427)
10 20 30 40 50 60
pF1KE4 MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 PVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 SIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 FMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 LREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLP
370 380 390 400 410 420
pF1KE4 EPNQQSK
::.::::
NP_002 EPSQQSK
>>XP_005258939 (OMIM: 602754,616689) PREDICTED: intermed (395 aa)
initn: 2613 init1: 2272 opt: 2273 Z-score: 2349.8 bits: 443.7 E(85289): 3.8e-124
Smith-Waterman score: 2553; 92.3% identity (92.5% similar) in 427 aa overlap (1-427:1-395)
10 20 30 40 50 60
pF1KE4 MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFL
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCS-------
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 VKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPA
:::::::::::::::::::::::::::::::::::
XP_005 -------------------------LFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPA
60 70 80
130 140 150 160 170 180
pF1KE4 PVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYR
90 100 110 120 130 140
190 200 210 220 230 240
pF1KE4 SIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDT
150 160 170 180 190 200
250 260 270 280 290 300
pF1KE4 LWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHN
210 220 230 240 250 260
310 320 330 340 350 360
pF1KE4 FMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRK
270 280 290 300 310 320
370 380 390 400 410 420
pF1KE4 LREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLP
330 340 350 360 370 380
pF1KE4 EPNQQSK
::.::::
XP_005 EPSQQSK
390
>>XP_011525240 (OMIM: 602754,616689) PREDICTED: intermed (259 aa)
initn: 1532 init1: 1532 opt: 1547 Z-score: 1604.0 bits: 305.1 E(85289): 1.3e-82
Smith-Waterman score: 1547; 94.8% identity (95.2% similar) in 248 aa overlap (1-245:1-244)
10 20 30 40 50 60
pF1KE4 MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 PVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYR
130 140 150 160 170 180
190 200 210 220 230
pF1KE4 SIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHL---
:::::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_011 SIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAER----FTGHLFGL
190 200 210 220 230
240 250 260 270 280 290
pF1KE4 SDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKH
:: .:
XP_011 RTYLWDLPKGLPLPWRKETYFPN
240 250
>>XP_005258940 (OMIM: 602754,616689) PREDICTED: intermed (364 aa)
initn: 1326 init1: 1305 opt: 1306 Z-score: 1353.7 bits: 259.3 E(85289): 1.2e-68
Smith-Waterman score: 1306; 97.5% identity (99.0% similar) in 204 aa overlap (224-427:161-364)
200 210 220 230 240 250
pF1KE4 FVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDTLWLIPITFLTIGY
.: :.::::::::::::::::::::::::
XP_005 LVRGQALHEHAPWPPAARPHAWPLADHRLGAVRGREAVNATGHLSDTLWLIPITFLTIGY
140 150 160 170 180 190
260 270 280 290 300 310
pF1KE4 GDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKE
200 210 220 230 240 250
320 330 340 350 360 370
pF1KE4 SAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISK
260 270 280 290 300 310
380 390 400 410 420
pF1KE4 MHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLPEPNQQSK
:::::::::::::::::::::::::::::::::::::::::::::::::.::::
XP_005 MHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLPEPSQQSK
320 330 340 350 360
>>NP_002240 (OMIM: 602983) small conductance calcium-act (731 aa)
initn: 1138 init1: 425 opt: 1154 Z-score: 1193.2 bits: 230.6 E(85289): 1e-59
Smith-Waterman score: 1154; 46.6% identity (75.8% similar) in 401 aa overlap (12-407:270-667)
10 20 30 40
pF1KE4 MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMV
: .:. :.:..: :. .::... :: .::
NP_002 THNHQHAGTTASSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMV
240 250 260 270 280 290
50 60 70 80 90 100
pF1KE4 LHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALT
...:. : . ... . .:: ::.::..:: ::.:.:..:::::. ::: :::.:.:
NP_002 IETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMT
300 310 320 330 340 350
110 120 130 140 150 160
pF1KE4 GRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLY
.. : ::..::..:: : . : .:. . . . .::. :.::::
NP_002 YERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEA---DVDIILSIPMFLRLY
360 370 380 390 400 410
170 180 190 200 210 220
pF1KE4 LVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAW
:. :..::.: .. .:: :::::::.. : :: : :. :: .:: ....::. .::
NP_002 LIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAW
420 430 440 450 460 470
230 240 250 260 270
pF1KE4 VLSVAER--QAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTA
.. : :: . ..:... ..::: ::::.:::::.:: :. :: ::: ::.::. :::
NP_002 TVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTA
480 490 500 510 520 530
280 290 300 310 320 330
pF1KE4 LLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTR--RKESHA-
:.:::::::::..:::::::::::: : ::..:..:: ::.:.:..::::. .: .::
NP_002 LVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAK
540 550 560 570 580 590
340 350 360 370 380 390
pF1KE4 ARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQI
.:.::::.: ::. .:.:....::: .:.:..::.:::. ..::: .:.. . :::::
NP_002 VRKHQRKFLQAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQI
600 610 620 630 640 650
400 410 420
pF1KE4 DTLAGKLDALTELLSTALGPRQLPEPNQQSK
.: .::. ::
NP_002 GSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARGVSVAVGTTHTPISDSPIGV
660 670 680 690 700 710
>>XP_005259964 (OMIM: 602982) PREDICTED: small conductan (623 aa)
initn: 987 init1: 442 opt: 1136 Z-score: 1175.6 bits: 227.1 E(85289): 9.7e-59
Smith-Waterman score: 1138; 45.2% identity (73.5% similar) in 423 aa overlap (12-422:176-595)
10 20 30 40
pF1KE4 MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMV
: .:. :.:..: :. .::... :: .::
XP_005 PQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIVVMV
150 160 170 180 190 200
50 60 70 80 90 100
pF1KE4 LHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALT
..:. : . .:: : .:: ::.:: .:: :.: .::.:.::::.::: :::.:.:
XP_005 TETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRIAMT
210 220 230 240 250 260
110 120 130 140 150 160
pF1KE4 GRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLY
... : :::.::..::.: . : .:. . . ..:::. :.::::
XP_005 CERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADV---DVLLSIPMFLRLY
270 280 290 300 310 320
170 180 190 200 210 220
pF1KE4 LVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAW
:. :..::.: .. .:: :::::::.. : :: : :. :: .:: .... :. .::
XP_005 LLGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAW
330 340 350 360 370 380
230 240 250 260 270
pF1KE4 VLSVAER--QAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTA
.. : :: . ..:... ..::: ::::.:::::.:: :. :: ::: ::.::. :::
XP_005 TVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTA
390 400 410 420 430 440
280 290 300 310 320 330
pF1KE4 LLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTR--RKESHA-
:.:::::::::..:::::::::::: : ::..:..:: ::.:.:..::::: .: ..:
XP_005 LVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQAR
450 460 470 480 490 500
340 350 360 370 380 390
pF1KE4 ARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQI
.:.::::.: ::. .:.:.... :: .:.:...:..: . ..::: ..: ..:. :: ..
XP_005 VRKHQRKFLQAIHQLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELEARL
510 520 530 540 550 560
400 410 420
pF1KE4 DTLAGKLDALTE-------LLSTALGPRQLPEPNQQSK
:: ..:::: :.. :. : : :
XP_005 ATLESRLDALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAPSDC
570 580 590 600 610 620
XP_005 G
>>XP_011526306 (OMIM: 602982) PREDICTED: small conductan (626 aa)
initn: 729 init1: 442 opt: 1136 Z-score: 1175.5 bits: 227.1 E(85289): 9.7e-59
Smith-Waterman score: 1138; 44.8% identity (73.2% similar) in 426 aa overlap (12-422:176-598)
10 20 30 40
pF1KE4 MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMV
: .:. :.:..: :. .::... :: .::
XP_011 PQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIVVMV
150 160 170 180 190 200
50 60 70 80 90 100
pF1KE4 LHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALT
..:. : . .:: : .:: ::.:: .:: :.: .::.:.::::.::: :::.:.:
XP_011 TETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRIAMT
210 220 230 240 250 260
110 120 130 140 150 160
pF1KE4 GRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLY
... : :::.::..::.: . : .:. . . ..:::. :.::::
XP_011 CERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADV---DVLLSIPMFLRLY
270 280 290 300 310 320
170 180 190 200 210 220
pF1KE4 LVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAW
:. :..::.: .. .:: :::::::.. : :: : :. :: .:: .... :. .::
XP_011 LLGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAW
330 340 350 360 370 380
230 240 250 260 270
pF1KE4 VLSVAERQAV-----NATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVC
.. : ::. . ..:... ..::: ::::.:::::.:: :. :: ::: ::.::.
XP_011 TVRVCERENMYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAG
390 400 410 420 430 440
280 290 300 310 320 330
pF1KE4 CTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTR--RKES
::::.:::::::::..:::::::::::: : ::..:..:: ::.:.:..::::: .: .
XP_011 CTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPD
450 460 470 480 490 500
340 350 360 370 380 390
pF1KE4 HA-ARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALE
.: .:.::::.: ::. .:.:.... :: .:.:...:..: . ..::: ..: ..:. ::
XP_011 QARVRKHQRKFLQAIHQLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELE
510 520 530 540 550 560
400 410 420
pF1KE4 KQIDTLAGKLDALTE-------LLSTALGPRQLPEPNQQSK
.. :: ..:::: :.. :. : : :
XP_011 ARLATLESRLDALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAP
570 580 590 600 610 620
XP_011 SDCG
>>NP_067627 (OMIM: 605879) small conductance calcium-act (579 aa)
initn: 1110 init1: 417 opt: 1131 Z-score: 1170.8 bits: 226.1 E(85289): 1.8e-58
Smith-Waterman score: 1131; 46.0% identity (76.0% similar) in 400 aa overlap (12-406:121-517)
10 20 30 40
pF1KE4 MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMV
: .:. :.:..: :. .::... :: .::
NP_067 GGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMV
100 110 120 130 140 150
50 60 70 80 90 100
pF1KE4 LHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALT
...:. : . . .:: . .:: ::.::..:: ::...::.:.::::.::: :::.:.:
NP_067 IETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMT
160 170 180 190 200 210
110 120 130 140 150 160
pF1KE4 GRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLY
.. : ::..::..:: : : . : : .. . .::. :.::::
NP_067 YERIFFICLEILVCAIHPIP--GNYTFTWTARLAFSYAP-STTTADVDIILSIPMFLRLY
220 230 240 250 260
170 180 190 200 210 220
pF1KE4 LVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAW
:. :..::.: .. .:: :::::::.. : :: : :. :: .:: ....::. .::
NP_067 LIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAW
270 280 290 300 310 320
230 240 250 260 270
pF1KE4 VLSVAER--QAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTA
.. . :: . ..:... ..::: ::::.:::::.::.:. :: ::: ::.::. :::
NP_067 TVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTA
330 340 350 360 370 380
280 290 300 310 320 330
pF1KE4 LLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTR--RKESHA-
:.:::::::::..:::::::::::: : ::..:..:: ::.:.:..::.:. .: .::
NP_067 LVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAK
390 400 410 420 430 440
340 350 360 370 380 390
pF1KE4 ARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQI
.:.::::.: ::. .:.:....::: .:.:..::..: . :.::. ..:. . .::.:
NP_067 VRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRI
450 460 470 480 490 500
400 410 420
pF1KE4 DTLAGKLDALTELLSTALGPRQLPEPNQQSK
:: ::..:
NP_067 VTLETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSSSRRRRS
510 520 530 540 550 560
>>XP_011541691 (OMIM: 605879) PREDICTED: small conductan (857 aa)
initn: 1110 init1: 417 opt: 1131 Z-score: 1168.6 bits: 226.3 E(85289): 2.4e-58
Smith-Waterman score: 1131; 46.0% identity (76.0% similar) in 400 aa overlap (12-406:399-795)
10 20 30 40
pF1KE4 MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMV
: .:. :.:..: :. .::... :: .::
XP_011 GGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMV
370 380 390 400 410 420
50 60 70 80 90 100
pF1KE4 LHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALT
...:. : . . .:: . .:: ::.::..:: ::...::.:.::::.::: :::.:.:
XP_011 IETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMT
430 440 450 460 470 480
110 120 130 140 150 160
pF1KE4 GRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLY
.. : ::..::..:: : : . : : .. . .::. :.::::
XP_011 YERIFFICLEILVCAIHPIP--GNYTFTWTARLAFSYAP-STTTADVDIILSIPMFLRLY
490 500 510 520 530 540
170 180 190 200 210 220
pF1KE4 LVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAW
:. :..::.: .. .:: :::::::.. : :: : :. :: .:: ....::. .::
XP_011 LIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAW
550 560 570 580 590 600
230 240 250 260 270
pF1KE4 VLSVAER--QAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTA
.. . :: . ..:... ..::: ::::.:::::.::.:. :: ::: ::.::. :::
XP_011 TVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTA
610 620 630 640 650 660
280 290 300 310 320 330
pF1KE4 LLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTR--RKESHA-
:.:::::::::..:::::::::::: : ::..:..:: ::.:.:..::.:. .: .::
XP_011 LVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAK
670 680 690 700 710 720
340 350 360 370 380 390
pF1KE4 ARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQI
.:.::::.: ::. .:.:....::: .:.:..::..: . :.::. ..:. . .::.:
XP_011 VRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRI
730 740 750 760 770 780
400 410 420
pF1KE4 DTLAGKLDALTELLSTALGPRQLPEPNQQSK
:: ::..:
XP_011 VTLETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSSSRRRRS
790 800 810 820 830 840
>>XP_011541689 (OMIM: 605879) PREDICTED: small conductan (857 aa)
initn: 1110 init1: 417 opt: 1131 Z-score: 1168.6 bits: 226.3 E(85289): 2.4e-58
Smith-Waterman score: 1131; 46.0% identity (76.0% similar) in 400 aa overlap (12-406:399-795)
10 20 30 40
pF1KE4 MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMV
: .:. :.:..: :. .::... :: .::
XP_011 GGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMV
370 380 390 400 410 420
50 60 70 80 90 100
pF1KE4 LHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALT
...:. : . . .:: . .:: ::.::..:: ::...::.:.::::.::: :::.:.:
XP_011 IETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMT
430 440 450 460 470 480
110 120 130 140 150 160
pF1KE4 GRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLY
.. : ::..::..:: : : . : : .. . .::. :.::::
XP_011 YERIFFICLEILVCAIHPIP--GNYTFTWTARLAFSYAP-STTTADVDIILSIPMFLRLY
490 500 510 520 530 540
170 180 190 200 210 220
pF1KE4 LVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAW
:. :..::.: .. .:: :::::::.. : :: : :. :: .:: ....::. .::
XP_011 LIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAW
550 560 570 580 590 600
230 240 250 260 270
pF1KE4 VLSVAER--QAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTA
.. . :: . ..:... ..::: ::::.:::::.::.:. :: ::: ::.::. :::
XP_011 TVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTA
610 620 630 640 650 660
280 290 300 310 320 330
pF1KE4 LLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTR--RKESHA-
:.:::::::::..:::::::::::: : ::..:..:: ::.:.:..::.:. .: .::
XP_011 LVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAK
670 680 690 700 710 720
340 350 360 370 380 390
pF1KE4 ARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQI
.:.::::.: ::. .:.:....::: .:.:..::..: . :.::. ..:. . .::.:
XP_011 VRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRI
730 740 750 760 770 780
400 410 420
pF1KE4 DTLAGKLDALTELLSTALGPRQLPEPNQQSK
:: ::..:
XP_011 VTLETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSSSRRRRS
790 800 810 820 830 840
427 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 09:25:01 2016 done: Sun Nov 6 09:25:02 2016
Total Scan time: 8.530 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]