FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4434, 452 aa 1>>>pF1KE4434 452 - 452 aa - 452 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7051+/-0.000416; mu= 15.2255+/- 0.026 mean_var=64.1998+/-12.793, 0's: 0 Z-trim(110.4): 41 B-trim: 255 in 1/52 Lambda= 0.160069 statistics sampled from 18699 (18721) to 18699 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.594), E-opt: 0.2 (0.22), width: 16 Scan time: 9.000 The best scores are: opt bits E(85289) NP_000268 (OMIM: 261600,612349) phenylalanine-4-hy ( 452) 3019 706.3 4.3e-203 NP_775489 (OMIM: 607478,608516,613003) tryptophan ( 490) 1675 395.9 1.2e-109 NP_004170 (OMIM: 191060) tryptophan 5-hydroxylase ( 444) 1617 382.5 1.2e-105 XP_016874859 (OMIM: 261600,612349) PREDICTED: phen ( 240) 1571 371.8 1.1e-102 NP_000351 (OMIM: 191290,605407) tyrosine 3-monooxy ( 497) 1507 357.1 6e-98 XP_011518637 (OMIM: 191290,605407) PREDICTED: tyro ( 501) 1507 357.1 6.1e-98 NP_954987 (OMIM: 191290,605407) tyrosine 3-monooxy ( 524) 1507 357.1 6.3e-98 NP_954986 (OMIM: 191290,605407) tyrosine 3-monooxy ( 528) 1507 357.1 6.4e-98 >>NP_000268 (OMIM: 261600,612349) phenylalanine-4-hydrox (452 aa) initn: 3019 init1: 3019 opt: 3019 Z-score: 3767.2 bits: 706.3 E(85289): 4.3e-203 Smith-Waterman score: 3019; 99.8% identity (99.8% similar) in 452 aa overlap (1-452:1-452) 10 20 30 40 50 60 pF1KE4 MSTAVLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEEVGALAKVLRLFEENDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MSTAVLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEEVGALAKVLRLFEENDV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 NLTHIESRPSRLKKDEYEFFTHLDKRSLPALTNIIKILRHDIGATVHELSRDKKKDTVPW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 NLTHIESRPSRLKKDEYEFFTHLDKRSLPALTNIIKILRHDIGATVHELSRDKKKDTVPW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 FPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 FPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 EEGKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGF :: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 EEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 RLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 QFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 QFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCLSE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 KPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYTQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 KPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYTQR 370 380 390 400 410 420 430 440 450 pF1KE4 IEVLDNTQQLKILADSINSEIGILCSALQKIK :::::::::::::::::::::::::::::::: NP_000 IEVLDNTQQLKILADSINSEIGILCSALQKIK 430 440 450 >>NP_775489 (OMIM: 607478,608516,613003) tryptophan 5-hy (490 aa) initn: 1637 init1: 1488 opt: 1675 Z-score: 2089.2 bits: 395.9 E(85289): 1.2e-109 Smith-Waterman score: 1675; 54.1% identity (81.3% similar) in 455 aa overlap (1-451:31-484) 10 20 30 pF1KE4 MSTAVLENPGLGRKLSDFGQETSYIEDNCN .....:..:. :.. .: :.. : .. . NP_775 MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTLNKPNSGKN-DDKGNKGSSKREAAT 10 20 30 40 50 40 50 60 70 80 pF1KE4 QNGAISLIFSLKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFFTHLD--KRSL ..: ...::::.:::.:.:.::::.:. ::..::::: :: ...: :.:. . : . NP_775 ESGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEF 60 70 80 90 100 110 90 100 110 120 130 140 pF1KE4 PALTNIIKILRHDIGATVHE--LSRDKKKDTVPWFPRTIQELDRFANQILSYGAELDADH : ...:. . . : ..... . :::::: :.:::. ....: ::.:::::: NP_775 NELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADH 120 130 140 150 160 170 150 160 170 180 190 200 pF1KE4 PGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEGKKTWGTVFKTLKSLYKTHACYEY ::::: ::: ::: :.:.:..:..::::::::: :: ::::.::. :..:: :::: :: NP_775 PGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREY 180 190 200 210 220 230 210 220 230 240 250 260 pF1KE4 NHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCT . :::: ::::..:::.:::::::.::. .:: .::::: :: ::::.:::.:::::: NP_775 LKNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCT 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE4 QYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYW ::::::: :.:::::: ::::::::::..: .::::::::::::::: :: ..:::: :. NP_775 QYIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYF 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE4 FTVEFGLCKQGDSIKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTAIQNYTVTEFQPLY ::.::::::: ...:::::::::.:::.. ::.: . .. . : .:. .: :: : NP_775 FTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAY 360 370 380 390 400 410 390 400 410 420 430 440 pF1KE4 YVAESFNDAKEKVRNFAATIPRPFSVRYDPYTQRIEVLDNTQQLKILADSINSEIGILCS .:.:::..::::.:.:: .: ::::: ..:::: ::.: .:.... ..... :... .:. NP_775 FVSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCD 420 430 440 450 460 470 450 pF1KE4 ALQKIK ::.:. NP_775 ALNKMNQYLGI 480 490 >>NP_004170 (OMIM: 191060) tryptophan 5-hydroxylase 1 [H (444 aa) initn: 1613 init1: 1449 opt: 1617 Z-score: 2017.5 bits: 382.5 E(85289): 1.2e-105 Smith-Waterman score: 1617; 56.1% identity (80.3% similar) in 431 aa overlap (26-451:9-438) 10 20 30 40 50 60 pF1KE4 MSTAVLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEEVGALAKVLRLFEENDV .:. . : :::::::.:::.: :.:..:.:. : NP_004 MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHV 10 20 30 40 70 80 90 100 110 pF1KE4 NLTHIESRPSRLKKDEYEFFTHLDKRSLPALTNIIKILRHDIGATVHELSRD--KKKD-- :: ::::: :. ...:.:.:. : :..:...:. .. .: . :.: NP_004 NLLHIESRKSKRRNSEFEIFVDCDINR-EQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGM 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE4 -TVPWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIP ::::::. :..::. ::..: ::.::::::::::: ::: ::: :::.:.::.::.::: NP_004 ETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIP 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE4 RVEYMEEGKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQ .::. :: :::::::. :..:: :::: :: . .::: ::::..:::::::::::.::. NP_004 KVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLK 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE4 TCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFS ::: .::::: :: ::::.::::::::::::.::.: :.:::::: ::::::::::.. NP_004 ERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLA 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE4 DRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQ . :::::::::::::::: .: ..:::: :.:::::::::: .....:::::::..::. NP_004 EPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELK 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE4 YCLSEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYD . :: . :. :.. . : :. .: :: .:.:.:::.:::::.:.:. :: :::.:.:. NP_004 HALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYN 350 360 370 380 390 400 420 430 440 450 pF1KE4 PYTQRIEVLDNTQQLKILADSINSEIGILCSALQKIK :::. :..: .:... . .. .. .. .:: :. NP_004 PYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI 410 420 430 440 >>XP_016874859 (OMIM: 261600,612349) PREDICTED: phenylal (240 aa) initn: 1571 init1: 1571 opt: 1571 Z-score: 1964.5 bits: 371.8 E(85289): 1.1e-102 Smith-Waterman score: 1571; 99.6% identity (99.6% similar) in 235 aa overlap (1-235:1-235) 10 20 30 40 50 60 pF1KE4 MSTAVLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEEVGALAKVLRLFEENDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSTAVLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEEVGALAKVLRLFEENDV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 NLTHIESRPSRLKKDEYEFFTHLDKRSLPALTNIIKILRHDIGATVHELSRDKKKDTVPW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NLTHIESRPSRLKKDEYEFFTHLDKRSLPALTNIIKILRHDIGATVHELSRDKKKDTVPW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 FPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 EEGKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGF :: :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQIPAVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 RLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFA >>NP_000351 (OMIM: 191290,605407) tyrosine 3-monooxygena (497 aa) initn: 1512 init1: 1433 opt: 1507 Z-score: 1879.4 bits: 357.1 E(85289): 6e-98 Smith-Waterman score: 1507; 53.0% identity (78.0% similar) in 423 aa overlap (35-451:82-496) 10 20 30 40 50 60 pF1KE4 VLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKE-EVGALAKVLRLFEENDVNLT ..:.:: . . .::......:: .... NP_000 AVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPRATKPSALSRAVKVFETFEAKIH 60 70 80 90 100 110 70 80 90 100 110 pF1KE4 HIESRPS---RLKKDEYEFFTHLDKR--SLPALTNIIKILRHDIGATVHELSRDKKKDTV :.:.::. : . :.:..:. : .: :: . .. . .:. :. : NP_000 HLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSEDV--------RSPAGPKV 120 130 140 150 160 120 130 140 150 160 170 pF1KE4 PWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVE ::::: ..:::. . . .. .:: :::::.: ::: ::: .:.::..::::.:::::: NP_000 PWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVE 170 180 190 200 210 220 180 190 200 210 220 230 pF1KE4 YMEEGKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCT : : :: :. :::.:: :::: :. . : :::.. :..:::::::::::.::. : NP_000 YTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKERT 230 240 250 260 270 280 240 250 260 270 280 290 pF1KE4 GFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRS ::.:::::::::.::::..::::::.:::::::.:.::..:::: :::::::::...::. NP_000 GFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRT 290 300 310 320 330 340 300 310 320 330 340 350 pF1KE4 FAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCL ::::::.:::::::: :: ::::.:.::::::::::::. .::::::::::.::: .:: NP_000 FAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCL 350 360 370 380 390 400 360 370 380 390 400 410 pF1KE4 SEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYT ::.:.. .. : .:.: : .: .:.:.:::.:::.:.:..:. : :::::..:::: NP_000 SEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYT 410 420 430 440 450 460 420 430 440 450 pF1KE4 QRIEVLDNTQQLKILADSINSEIGILCSALQKIK :.:::. : .. .....:. : ::. : NP_000 LAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG 470 480 490 >>XP_011518637 (OMIM: 191290,605407) PREDICTED: tyrosine (501 aa) initn: 1512 init1: 1433 opt: 1507 Z-score: 1879.4 bits: 357.1 E(85289): 6.1e-98 Smith-Waterman score: 1507; 53.0% identity (78.0% similar) in 423 aa overlap (35-451:86-500) 10 20 30 40 50 60 pF1KE4 VLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKE-EVGALAKVLRLFEENDVNLT ..:.:: . . .::......:: .... XP_011 AVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPRATKPSALSRAVKVFETFEAKIH 60 70 80 90 100 110 70 80 90 100 110 pF1KE4 HIESRPS---RLKKDEYEFFTHLDKR--SLPALTNIIKILRHDIGATVHELSRDKKKDTV :.:.::. : . :.:..:. : .: :: . .. . .:. :. : XP_011 HLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSEDV--------RSPAGPKV 120 130 140 150 160 120 130 140 150 160 170 pF1KE4 PWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVE ::::: ..:::. . . .. .:: :::::.: ::: ::: .:.::..::::.:::::: XP_011 PWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVE 170 180 190 200 210 220 180 190 200 210 220 230 pF1KE4 YMEEGKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCT : : :: :. :::.:: :::: :. . : :::.. :..:::::::::::.::. : XP_011 YTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKERT 230 240 250 260 270 280 240 250 260 270 280 290 pF1KE4 GFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRS ::.:::::::::.::::..::::::.:::::::.:.::..:::: :::::::::...::. XP_011 GFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRT 290 300 310 320 330 340 300 310 320 330 340 350 pF1KE4 FAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCL ::::::.:::::::: :: ::::.:.::::::::::::. .::::::::::.::: .:: XP_011 FAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCL 350 360 370 380 390 400 360 370 380 390 400 410 pF1KE4 SEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYT ::.:.. .. : .:.: : .: .:.:.:::.:::.:.:..:. : :::::..:::: XP_011 SEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYT 410 420 430 440 450 460 420 430 440 450 pF1KE4 QRIEVLDNTQQLKILADSINSEIGILCSALQKIK :.:::. : .. .....:. : ::. : XP_011 LAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG 470 480 490 500 >>NP_954987 (OMIM: 191290,605407) tyrosine 3-monooxygena (524 aa) initn: 1512 init1: 1433 opt: 1507 Z-score: 1879.1 bits: 357.1 E(85289): 6.3e-98 Smith-Waterman score: 1507; 53.0% identity (78.0% similar) in 423 aa overlap (35-451:109-523) 10 20 30 40 50 60 pF1KE4 VLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKE-EVGALAKVLRLFEENDVNLT ..:.:: . . .::......:: .... NP_954 AVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPRATKPSALSRAVKVFETFEAKIH 80 90 100 110 120 130 70 80 90 100 110 pF1KE4 HIESRPS---RLKKDEYEFFTHLDKR--SLPALTNIIKILRHDIGATVHELSRDKKKDTV :.:.::. : . :.:..:. : .: :: . .. . .:. :. : NP_954 HLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSEDV--------RSPAGPKV 140 150 160 170 180 190 120 130 140 150 160 170 pF1KE4 PWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVE ::::: ..:::. . . .. .:: :::::.: ::: ::: .:.::..::::.:::::: NP_954 PWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVE 200 210 220 230 240 250 180 190 200 210 220 230 pF1KE4 YMEEGKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCT : : :: :. :::.:: :::: :. . : :::.. :..:::::::::::.::. : NP_954 YTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKERT 260 270 280 290 300 310 240 250 260 270 280 290 pF1KE4 GFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRS ::.:::::::::.::::..::::::.:::::::.:.::..:::: :::::::::...::. NP_954 GFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRT 320 330 340 350 360 370 300 310 320 330 340 350 pF1KE4 FAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCL ::::::.:::::::: :: ::::.:.::::::::::::. .::::::::::.::: .:: NP_954 FAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCL 380 390 400 410 420 430 360 370 380 390 400 410 pF1KE4 SEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYT ::.:.. .. : .:.: : .: .:.:.:::.:::.:.:..:. : :::::..:::: NP_954 SEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYT 440 450 460 470 480 490 420 430 440 450 pF1KE4 QRIEVLDNTQQLKILADSINSEIGILCSALQKIK :.:::. : .. .....:. : ::. : NP_954 LAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG 500 510 520 >>NP_954986 (OMIM: 191290,605407) tyrosine 3-monooxygena (528 aa) initn: 1512 init1: 1433 opt: 1507 Z-score: 1879.0 bits: 357.1 E(85289): 6.4e-98 Smith-Waterman score: 1507; 53.0% identity (78.0% similar) in 423 aa overlap (35-451:113-527) 10 20 30 40 50 60 pF1KE4 VLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKE-EVGALAKVLRLFEENDVNLT ..:.:: . . .::......:: .... NP_954 AVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPRATKPSALSRAVKVFETFEAKIH 90 100 110 120 130 140 70 80 90 100 110 pF1KE4 HIESRPS---RLKKDEYEFFTHLDKR--SLPALTNIIKILRHDIGATVHELSRDKKKDTV :.:.::. : . :.:..:. : .: :: . .. . .:. :. : NP_954 HLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSEDV--------RSPAGPKV 150 160 170 180 190 120 130 140 150 160 170 pF1KE4 PWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVE ::::: ..:::. . . .. .:: :::::.: ::: ::: .:.::..::::.:::::: NP_954 PWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVE 200 210 220 230 240 250 180 190 200 210 220 230 pF1KE4 YMEEGKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCT : : :: :. :::.:: :::: :. . : :::.. :..:::::::::::.::. : NP_954 YTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKERT 260 270 280 290 300 310 240 250 260 270 280 290 pF1KE4 GFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRS ::.:::::::::.::::..::::::.:::::::.:.::..:::: :::::::::...::. NP_954 GFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRT 320 330 340 350 360 370 300 310 320 330 340 350 pF1KE4 FAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCL ::::::.:::::::: :: ::::.:.::::::::::::. .::::::::::.::: .:: NP_954 FAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCL 380 390 400 410 420 430 360 370 380 390 400 410 pF1KE4 SEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYT ::.:.. .. : .:.: : .: .:.:.:::.:::.:.:..:. : :::::..:::: NP_954 SEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYT 440 450 460 470 480 490 420 430 440 450 pF1KE4 QRIEVLDNTQQLKILADSINSEIGILCSALQKIK :.:::. : .. .....:. : ::. : NP_954 LAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG 500 510 520 452 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 01:09:51 2016 done: Sun Nov 6 01:09:53 2016 Total Scan time: 9.000 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]