FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2541, 323 aa 1>>>pF1KE2541 323 - 323 aa - 323 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8791+/-0.000425; mu= 17.8513+/- 0.026 mean_var=62.3130+/-12.885, 0's: 0 Z-trim(110.5): 59 B-trim: 68 in 1/49 Lambda= 0.162474 statistics sampled from 18757 (18816) to 18757 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.584), E-opt: 0.2 (0.221), width: 16 Scan time: 5.870 The best scores are: opt bits E(85289) NP_001641 (OMIM: 600308) aquaporin-4 isoform M1 [H ( 323) 2156 514.3 1.4e-145 NP_001304313 (OMIM: 600308) aquaporin-4 isoform M1 ( 352) 2156 514.3 1.5e-145 XP_011524244 (OMIM: 600308) PREDICTED: aquaporin-4 ( 316) 2072 494.6 1.2e-139 NP_004019 (OMIM: 600308) aquaporin-4 isoform M23 [ ( 301) 1987 474.6 1.1e-133 NP_001304316 (OMIM: 600308) aquaporin-4 isoform de ( 296) 1362 328.1 1.4e-89 NP_001642 (OMIM: 600442) aquaporin-5 [Homo sapiens ( 265) 796 195.4 1.1e-49 NP_036196 (OMIM: 154050,615274) lens fiber major i ( 263) 792 194.5 2.1e-49 NP_000477 (OMIM: 107777,125800) aquaporin-2 [Homo ( 271) 776 190.7 2.9e-48 NP_932766 (OMIM: 107776,110450) aquaporin-1 isofor ( 269) 722 178.1 1.8e-44 NP_001316801 (OMIM: 107776,110450) aquaporin-1 iso ( 323) 717 177.0 4.8e-44 XP_005268895 (OMIM: 600442) PREDICTED: aquaporin-5 ( 222) 677 167.5 2.4e-41 NP_001643 (OMIM: 601383) aquaporin-6 [Homo sapiens ( 282) 664 164.5 2.4e-40 XP_016874795 (OMIM: 154050,615274) PREDICTED: lens ( 144) 424 108.0 1.2e-23 XP_011536656 (OMIM: 154050,615274) PREDICTED: lens ( 168) 417 106.4 4.2e-23 NP_001160 (OMIM: 603750) aquaporin-8 [Homo sapiens ( 261) 395 101.4 2.1e-21 XP_011544124 (OMIM: 603750) PREDICTED: aquaporin-8 ( 262) 395 101.4 2.1e-21 XP_011544125 (OMIM: 603750) PREDICTED: aquaporin-8 ( 148) 211 58.1 1.3e-08 NP_001307564 (OMIM: 602914) aquaporin-9 isoform 2 ( 193) 194 54.2 2.5e-07 NP_066190 (OMIM: 602914) aquaporin-9 isoform 1 [Ho ( 295) 196 54.8 2.6e-07 NP_001305073 (OMIM: 600170,607457) aquaporin-3 iso ( 237) 179 50.8 3.4e-06 NP_004916 (OMIM: 600170,607457) aquaporin-3 isofor ( 292) 179 50.8 4e-06 NP_001307565 (OMIM: 602914) aquaporin-9 isoform 3 ( 230) 161 46.5 6.2e-05 NP_001305086 (OMIM: 602974,614411) aquaporin-7 iso ( 256) 156 45.4 0.00015 NP_001305087 (OMIM: 602974,614411) aquaporin-7 iso ( 257) 156 45.4 0.00015 XP_016870189 (OMIM: 602974,614411) PREDICTED: aqua ( 341) 156 45.5 0.00019 NP_001161 (OMIM: 602974,614411) aquaporin-7 isofor ( 342) 156 45.5 0.00019 XP_005251510 (OMIM: 602974,614411) PREDICTED: aqua ( 342) 156 45.5 0.00019 XP_011516168 (OMIM: 602974,614411) PREDICTED: aqua ( 342) 156 45.5 0.00019 NP_536354 (OMIM: 606578) aquaporin-10 [Homo sapien ( 301) 151 44.3 0.00039 XP_016870192 (OMIM: 602974,614411) PREDICTED: aqua ( 250) 149 43.7 0.00047 XP_016870190 (OMIM: 602974,614411) PREDICTED: aqua ( 250) 149 43.7 0.00047 XP_016870193 (OMIM: 602974,614411) PREDICTED: aqua ( 250) 149 43.7 0.00047 XP_016870191 (OMIM: 602974,614411) PREDICTED: aqua ( 250) 149 43.7 0.00047 XP_016870194 (OMIM: 602974,614411) PREDICTED: aqua ( 250) 149 43.7 0.00047 XP_011508406 (OMIM: 606578) PREDICTED: aquaporin-1 ( 302) 141 41.9 0.002 XP_016870195 (OMIM: 602974,614411) PREDICTED: aqua ( 200) 133 39.9 0.0053 NP_001305085 (OMIM: 602974,614411) aquaporin-7 iso ( 216) 133 39.9 0.0056 XP_006716828 (OMIM: 602974,614411) PREDICTED: aqua ( 285) 133 40.0 0.007 XP_011516169 (OMIM: 602974,614411) PREDICTED: aqua ( 285) 133 40.0 0.007 >>NP_001641 (OMIM: 600308) aquaporin-4 isoform M1 [Homo (323 aa) initn: 2156 init1: 2156 opt: 2156 Z-score: 2734.7 bits: 514.3 E(85289): 1.4e-145 Smith-Waterman score: 2156; 100.0% identity (100.0% similar) in 323 aa overlap (1-323:1-323) 10 20 30 40 50 60 pF1KE2 MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH 250 260 270 280 290 300 310 320 pF1KE2 VIDVDRGEEKKGKDQSGEVLSSV ::::::::::::::::::::::: NP_001 VIDVDRGEEKKGKDQSGEVLSSV 310 320 >>NP_001304313 (OMIM: 600308) aquaporin-4 isoform M1x [H (352 aa) initn: 2156 init1: 2156 opt: 2156 Z-score: 2734.2 bits: 514.3 E(85289): 1.5e-145 Smith-Waterman score: 2156; 100.0% identity (100.0% similar) in 323 aa overlap (1-323:1-323) 10 20 30 40 50 60 pF1KE2 MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH 250 260 270 280 290 300 310 320 pF1KE2 VIDVDRGEEKKGKDQSGEVLSSV ::::::::::::::::::::::: NP_001 VIDVDRGEEKKGKDQSGEVLSSVXLEDRTESRQDSLELSSDFLPPIKETDLL 310 320 330 340 350 >>XP_011524244 (OMIM: 600308) PREDICTED: aquaporin-4 iso (316 aa) initn: 2072 init1: 2072 opt: 2072 Z-score: 2628.4 bits: 494.6 E(85289): 1.2e-139 Smith-Waterman score: 2072; 100.0% identity (100.0% similar) in 312 aa overlap (12-323:5-316) 10 20 30 40 50 60 pF1KE2 MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG ::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MFEIKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE2 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE2 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH 240 250 260 270 280 290 310 320 pF1KE2 VIDVDRGEEKKGKDQSGEVLSSV ::::::::::::::::::::::: XP_011 VIDVDRGEEKKGKDQSGEVLSSV 300 310 >>NP_004019 (OMIM: 600308) aquaporin-4 isoform M23 [Homo (301 aa) initn: 1987 init1: 1987 opt: 1987 Z-score: 2521.0 bits: 474.6 E(85289): 1.1e-133 Smith-Waterman score: 1987; 100.0% identity (100.0% similar) in 301 aa overlap (23-323:1-301) 10 20 30 40 50 60 pF1KE2 MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG :::::::::::::::::::::::::::::::::::::: NP_004 MVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG 10 20 30 70 80 90 100 110 120 pF1KE2 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE2 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE2 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE2 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH 220 230 240 250 260 270 310 320 pF1KE2 VIDVDRGEEKKGKDQSGEVLSSV ::::::::::::::::::::::: NP_004 VIDVDRGEEKKGKDQSGEVLSSV 280 290 300 >>NP_001304316 (OMIM: 600308) aquaporin-4 isoform delta4 (296 aa) initn: 1362 init1: 1362 opt: 1362 Z-score: 1729.4 bits: 328.1 E(85289): 1.4e-89 Smith-Waterman score: 1892; 91.6% identity (91.6% similar) in 323 aa overlap (1-323:1-296) 10 20 30 40 50 60 pF1KE2 MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG ::::::::::::::::::::::::: :::::::: NP_001 KRTDVTGSIALAIGFSVAIGHLFAI---------------------------YWVGPIIG 190 200 210 250 260 270 280 290 300 pF1KE2 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH 220 230 240 250 260 270 310 320 pF1KE2 VIDVDRGEEKKGKDQSGEVLSSV ::::::::::::::::::::::: NP_001 VIDVDRGEEKKGKDQSGEVLSSV 280 290 >>NP_001642 (OMIM: 600442) aquaporin-5 [Homo sapiens] (265 aa) initn: 806 init1: 555 opt: 796 Z-score: 1013.1 bits: 195.4 E(85289): 1.1e-49 Smith-Waterman score: 796; 50.2% identity (77.2% similar) in 263 aa overlap (27-288:3-254) 10 20 30 40 50 60 pF1KE2 MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG : : . :: ::: ::::: ::::...:::...: NP_001 MKKEVCSVAFLKAVFAEFLATLIFVFFGLGSALKWP 10 20 30 70 80 90 100 110 120 pF1KE2 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA .. ::. .. :.: :::.:.:..: .: .::::::::.:.:.. .::. .. ::.: NP_001 SA---LPT-ILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLRAFFYVA 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE2 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS :: .::: :::::: :.: .. :.:.:. ...: : :....::::.::::.. :::: :: NP_001 AQLVGAIAGAGILYGVAPLNARGNLAVNALNNNTTQGQAMVVELILTFQLALCIFASTDS 100 110 120 130 140 150 190 200 210 220 230 pF1KE2 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWE-NHWIYWVGPII .::. .:: ::.::.::..::: .: .:: ::::::::::::.:. . ::..:::::. NP_001 RRTSPVGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPAHWVFWVGPIV 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE2 GAVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVV :::::. :: :.. :. . ..:. . ::.: :: . : : NP_001 GAVLAAILYFYLLFPN-------SLSLSERVAIIKGTYEPDEDWEEQREERKKTMELTTR 220 230 240 250 260 300 310 320 pF1KE2 HVIDVDRGEEKKGKDQSGEVLSSV >>NP_036196 (OMIM: 154050,615274) lens fiber major intri (263 aa) initn: 792 init1: 695 opt: 792 Z-score: 1008.0 bits: 194.5 E(85289): 2.1e-49 Smith-Waterman score: 792; 44.7% identity (77.8% similar) in 257 aa overlap (31-287:6-251) 10 20 30 40 50 60 pF1KE2 MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG . .::.:. :::.: :..:...:::.. :. NP_036 MWELRSASFWRAIFAEFFATLFYVFFGLGSSLRWA 10 20 30 70 80 90 100 110 120 pF1KE2 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA : :. .. ... :::..::.:: :::::.:.::::: :.. ..:. .. :.: NP_036 ----PGPLHVLQVAMAFGLALATLVQSVGHISGAHVNPAVTFAFLVGSQMSLLRAFCYMA 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE2 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS :: :::. ::..:: ::::.: :.:... .: ...:.. ::...:.:.:. :::. : NP_036 AQLLGAVAGAAVLYSVTPPAVRGNLALNTLHPAVSVGQATTVEIFLTLQFVLCIFATYDE 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE2 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG .:. ::.:::.:::.:.::::.. ::::.:::::::.::.. ::. :::.:::::::: NP_036 RRNGQLGSVALAVGFSLALGHLFGMYYTGAGMNPARSFAPAILTGNFTNHWVYWVGPIIG 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE2 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH . :.. ::.... : :.: ..:. . ::. .: ... .: NP_036 GGLGSLLYDFLLFP------RLK-SISERLSVLKGAKPDVSNGQPEVTGEPVELNTQAL 220 230 240 250 260 310 320 pF1KE2 VIDVDRGEEKKGKDQSGEVLSSV >>NP_000477 (OMIM: 107777,125800) aquaporin-2 [Homo sapi (271 aa) initn: 775 init1: 677 opt: 776 Z-score: 987.6 bits: 190.7 E(85289): 2.9e-48 Smith-Waterman score: 776; 51.4% identity (82.9% similar) in 222 aa overlap (33-254:8-225) 10 20 30 40 50 60 pF1KE2 DRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGT :: .:: ::::: :.::...:::..:: NP_000 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNW--- 10 20 30 70 80 90 100 110 120 pF1KE2 EKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQ . :: ... :.. :::.:.:.:: .:::::.::::::::: . ..:. ...::.::: NP_000 PQALP-SVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQ 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE2 CLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKR :::. ::..:. .:: .. : :.:. . .. :::... :::..:.:::. :::: : .: NP_000 LLGAVAGAALLHEITPADIRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERR 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE2 TDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAV . :. ::.::::::.:::..:.::: :::::::..:::. :....::..:.::..::. NP_000 GENPGTPALSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAI 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE2 LAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVI :.. ::.::. : NP_000 LGSLLYNYVLFPPAKSLSERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA 220 230 240 250 260 270 >>NP_932766 (OMIM: 107776,110450) aquaporin-1 isoform 1 (269 aa) initn: 698 init1: 608 opt: 722 Z-score: 919.2 bits: 178.1 E(85289): 1.8e-44 Smith-Waterman score: 722; 45.2% identity (75.7% similar) in 259 aa overlap (34-288:10-265) 10 20 30 40 50 60 pF1KE2 RPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG--- ::.::.::::: .::..:.::.... NP_932 MASEFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPV 10 20 30 70 80 90 100 110 120 pF1KE2 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA :... : : .:: :::::::..: :::::.:.:::::.... . .::: ....:: NP_932 GNNQTAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISIFRALMYII 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE2 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS :::.:::....:: .: . ..:: . . ....:.:: .:.: :.:::. ..:. : NP_932 AQCVGAIVATAILSGITSSLTGNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDR 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE2 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG .: :. :: ::::.:::.:::.::.::: ..::::::: ::: :. ::::.::::.:: NP_932 RRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIG 160 170 180 190 200 210 250 260 270 280 290 pF1KE2 AVLAGGLYEYVFCP-DVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVV ..:: .:.... : . .. : : : :.. ....: :.:: NP_932 GALAVLIYDFILAPRSSDLTDRVKVWTSG---QVEEYDLDADDINSRVEMKPK 220 230 240 250 260 300 310 320 pF1KE2 HVIDVDRGEEKKGKDQSGEVLSSV >>NP_001316801 (OMIM: 107776,110450) aquaporin-1 isoform (323 aa) initn: 720 init1: 630 opt: 717 Z-score: 911.8 bits: 177.0 E(85289): 4.8e-44 Smith-Waterman score: 717; 48.7% identity (79.5% similar) in 224 aa overlap (34-254:10-233) 10 20 30 40 50 60 pF1KE2 RPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG--- ::.::.::::: .::..:.::.... NP_001 MASEFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPV 10 20 30 70 80 90 100 110 120 pF1KE2 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA :... : : .:: :::::::..: :::::.:.:::::.... . .::: ....:: NP_001 GNNQTAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISIFRALMYII 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE2 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS :::.:::....:: .: . ..:: . . ....:.:: .:.: :.:::. ..:. : NP_001 AQCVGAIVATAILSGITSSLTGNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDR 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE2 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG .: :. :: ::::.:::.:::.::.::: ..::::::: ::: :. ::::.::::.:: NP_001 RRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIG 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE2 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH ..:: .:.... : NP_001 GALAVLIYDFILAPRSSDLTDRVKVWTSGQVEEYDLDADDINSRSFLGTKIYQFTHSLEV 220 230 240 250 260 270 323 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 03:42:06 2016 done: Tue Nov 8 03:42:07 2016 Total Scan time: 5.870 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]