FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5253, 199 aa 1>>>pF1KE5253 199 - 199 aa - 199 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1872+/-0.000434; mu= 10.4504+/- 0.027 mean_var=102.9204+/-20.218, 0's: 0 Z-trim(112.9): 22 B-trim: 665 in 1/54 Lambda= 0.126422 statistics sampled from 21959 (21971) to 21959 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.616), E-opt: 0.2 (0.258), width: 16 Scan time: 5.000 The best scores are: opt bits E(85289) NP_065145 (OMIM: 606486) charged multivesicular bo ( 199) 1228 234.2 1.1e-61 NP_002759 (OMIM: 164010,614961) charged multivesic ( 196) 682 134.6 1e-31 NP_055268 (OMIM: 610893) charged multivesicular bo ( 222) 296 64.2 1.8e-10 NP_940818 (OMIM: 610893) charged multivesicular bo ( 222) 296 64.2 1.8e-10 XP_005258803 (OMIM: 610893) PREDICTED: charged mul ( 265) 291 63.3 3.8e-10 XP_005258804 (OMIM: 610893) PREDICTED: charged mul ( 265) 291 63.3 3.8e-10 NP_054762 (OMIM: 600795,609512,614696) charged mul ( 213) 195 45.8 6e-05 XP_011531878 (OMIM: 600795,609512,614696) PREDICTE ( 229) 195 45.8 6.4e-05 NP_001231573 (OMIM: 600795,609512,614696) charged ( 172) 173 41.7 0.00082 >>NP_065145 (OMIM: 606486) charged multivesicular body p (199 aa) initn: 1228 init1: 1228 opt: 1228 Z-score: 1228.4 bits: 234.2 E(85289): 1.1e-61 Smith-Waterman score: 1228; 100.0% identity (100.0% similar) in 199 aa overlap (1-199:1-199) 10 20 30 40 50 60 pF1KE5 MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVARIHAENAIRQKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVARIHAENAIRQKN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 QAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLEKISALMDKFEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 QAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLEKISALMDKFEH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 QFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEAGLDLNMELPQGQTGSVGTSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 QFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEAGLDLNMELPQGQTGSVGTSV 130 140 150 160 170 180 190 pF1KE5 ASAEQDELSQRLARLRDQV ::::::::::::::::::: NP_065 ASAEQDELSQRLARLRDQV 190 >>NP_002759 (OMIM: 164010,614961) charged multivesicular (196 aa) initn: 723 init1: 609 opt: 682 Z-score: 690.3 bits: 134.6 E(85289): 1e-31 Smith-Waterman score: 682; 55.8% identity (85.3% similar) in 197 aa overlap (4-197:1-196) 10 20 30 40 50 60 pF1KE5 MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVARIHAENAIRQKN :. ::.:::.::.: . ::: .:. :::.::.:::. . :.: ::..::::::.:: NP_002 MDDTLFQLKFTAKQLEKLAKKAEKDSKAEQAKVKKALLQKNVECARVYAENAIRKKN 10 20 30 40 50 70 80 90 100 110 120 pF1KE5 QAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLEKISALMDKFEH ..::.:::..::::::..::::::: :::.:: :.:..: .:.::.:.:.:..::.::. NP_002 EGVNWLRMASRVDAVASKVQTAVTMKGVTKNMAQVTKALDKALSTMDLQKVSSVMDRFEQ 60 70 80 90 100 110 130 140 150 160 170 pF1KE5 QFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEAGL---DLNMELPQGQTGSVG : ..:::.:. :::.:::.:::::::.::: :....:.: :: : .::.: . .:: NP_002 QVQNLDVHTSVMEDSMSSATTLTTPQEQVDSLIMQIAEENGLEVLDQLSQLPEGAS-AVG 120 130 140 150 160 170 180 190 pF1KE5 TSVASAEQDELSQRLARLRDQV : . ...:.::.::: ::. NP_002 ESSVRSQEDQLSRRLAALRN 180 190 >>NP_055268 (OMIM: 610893) charged multivesicular body p (222 aa) initn: 342 init1: 287 opt: 296 Z-score: 309.1 bits: 64.2 E(85289): 1.8e-10 Smith-Waterman score: 299; 30.7% identity (66.3% similar) in 199 aa overlap (11-196:22-220) 10 20 30 40 pF1KE5 MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVAR :. : .::.: .: . .:: : ::: ..:.:...: NP_055 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE5 IHAENAIRQKNQAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLE : :.. .: . . .:. : : ..::. ..:: . ......: ::.:.: . . ..: NP_055 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE5 KISALMDKFEHQFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEAGLDLNMEL- .:. .: .::.: : .:.. ..:.:..... ... : ..... :: ::.:. :: NP_055 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS 130 140 150 160 170 180 170 180 190 pF1KE5 --PQ-GQTGSVGT------SVASAEQD---ELSQRLARLRDQV :. : . ::.. ..::: : .: .:: :: NP_055 NLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD 190 200 210 220 >>NP_940818 (OMIM: 610893) charged multivesicular body p (222 aa) initn: 342 init1: 287 opt: 296 Z-score: 309.1 bits: 64.2 E(85289): 1.8e-10 Smith-Waterman score: 299; 30.7% identity (66.3% similar) in 199 aa overlap (11-196:22-220) 10 20 30 40 pF1KE5 MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVAR :. : .::.: .: . .:: : ::: ..:.:...: NP_940 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE5 IHAENAIRQKNQAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLE : :.. .: . . .:. : : ..::. ..:: . ......: ::.:.: . . ..: NP_940 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE5 KISALMDKFEHQFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEAGLDLNMEL- .:. .: .::.: : .:.. ..:.:..... ... : ..... :: ::.:. :: NP_940 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS 130 140 150 160 170 180 170 180 190 pF1KE5 --PQ-GQTGSVGT------SVASAEQD---ELSQRLARLRDQV :. : . ::.. ..::: : .: .:: :: NP_940 NLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD 190 200 210 220 >>XP_005258803 (OMIM: 610893) PREDICTED: charged multive (265 aa) initn: 307 init1: 291 opt: 291 Z-score: 303.1 bits: 63.3 E(85289): 3.8e-10 Smith-Waterman score: 291; 30.4% identity (70.3% similar) in 158 aa overlap (11-168:22-179) 10 20 30 40 pF1KE5 MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVAR :. : .::.: .: . .:: : ::: ..:.:...: XP_005 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE5 IHAENAIRQKNQAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLE : :.. .: . . .:. : : ..::. ..:: . ......: ::.:.: . . ..: XP_005 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE5 KISALMDKFEHQFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEAGLDLNMELP .:. .: .::.: : .:.. ..:.:..... ... : ..... :: ::.:. :: XP_005 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS 130 140 150 160 170 180 170 180 190 pF1KE5 QGQTGSVGTSVASAEQDELSQRLARLRDQV XP_005 SECSKSWTPFPTQGPATAPSPPFPCITPLRCLTPPAQTPTFSADLPSTGGSLSVAAGGKK 190 200 210 220 230 240 >>XP_005258804 (OMIM: 610893) PREDICTED: charged multive (265 aa) initn: 307 init1: 291 opt: 291 Z-score: 303.1 bits: 63.3 E(85289): 3.8e-10 Smith-Waterman score: 291; 30.4% identity (70.3% similar) in 158 aa overlap (11-168:22-179) 10 20 30 40 pF1KE5 MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVAR :. : .::.: .: . .:: : ::: ..:.:...: XP_005 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE5 IHAENAIRQKNQAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLE : :.. .: . . .:. : : ..::. ..:: . ......: ::.:.: . . ..: XP_005 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE5 KISALMDKFEHQFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEAGLDLNMELP .:. .: .::.: : .:.. ..:.:..... ... : ..... :: ::.:. :: XP_005 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS 130 140 150 160 170 180 170 180 190 pF1KE5 QGQTGSVGTSVASAEQDELSQRLARLRDQV XP_005 SECSKSWTPFPTQGPATAPSPPFPCITPLRCLTPPAQTPTFSADLPSTGGSLSVAAGGKK 190 200 210 220 230 240 >>NP_054762 (OMIM: 600795,609512,614696) charged multive (213 aa) initn: 131 init1: 64 opt: 195 Z-score: 209.8 bits: 45.8 E(85289): 6e-05 Smith-Waterman score: 201; 19.5% identity (65.8% similar) in 190 aa overlap (11-195:21-210) 10 20 30 40 50 pF1KE5 MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVARI :. . . . :. .:.:: . .::: . :: :. .. NP_054 MASLFKKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACKV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 HAENAIRQKNQAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLEK :.. .. ..: . . .:..: ........ .. :.. .:. ..:.:.:. : :. .: NP_054 LAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQK 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE5 ISALMDKFEHQFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEAGLDLNMELPQ :..:... ... ....::... . ... . ..... :: :.... .. . NP_054 TLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAK 130 140 150 160 170 180 180 190 pF1KE5 GQTG-----SVGTSVASAEQDELSQRLARLRDQV . .. :..:: :. ..:. ..: : NP_054 APSAARSLPSASTSKATISDEEIERQLKALGVD 190 200 210 >>XP_011531878 (OMIM: 600795,609512,614696) PREDICTED: c (229 aa) initn: 131 init1: 64 opt: 195 Z-score: 209.3 bits: 45.8 E(85289): 6.4e-05 Smith-Waterman score: 201; 19.5% identity (65.8% similar) in 190 aa overlap (11-195:37-226) 10 20 30 40 pF1KE5 MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAI :. . . . :. .:.:: . .::: XP_011 NHHLPDSSDSSTSAYRVARITDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMA 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE5 QKGNMEVARIHAENAIRQKNQAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMD . :: :. .. :.. .. ..: . . .:..: ........ .. :.. .:. ..:.:. XP_011 KIGNKEACKVLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQ 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE5 ATLKTMNLEKISALMDKFEHQFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEA :. : :. .: :..:... ... ....::... . ... . ..... :: XP_011 AVNKKMDPQKTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEI 130 140 150 160 170 180 170 180 190 pF1KE5 GLDLNMELPQGQTG-----SVGTSVASAEQDELSQRLARLRDQV :.... .. .. .. :..:: :. ..:. ..: : XP_011 GIEISGKMAKAPSAARSLPSASTSKATISDEEIERQLKALGVD 190 200 210 220 >>NP_001231573 (OMIM: 600795,609512,614696) charged mult (172 aa) initn: 137 init1: 64 opt: 173 Z-score: 189.4 bits: 41.7 E(85289): 0.00082 Smith-Waterman score: 179; 19.3% identity (67.5% similar) in 166 aa overlap (35-195:4-169) 10 20 30 40 50 60 pF1KE5 EKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVARIHAENAIRQKNQAVN .::: . :: :. .. :.. .. ..: . NP_001 MELEIKKMAKIGNKEACKVLAKQLVHLRKQKTR 10 20 30 70 80 90 100 110 120 pF1KE5 FLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLEKISALMDKFEHQFET . .:..: ........ .. :.. .:. ..:.:.:. : :. .: :..:... NP_001 TFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKENMK 40 50 60 70 80 90 130 140 150 160 170 pF1KE5 LDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEAGLDLNMELPQGQTG-----SVGTS ... ....::... . ... . ..... :: :.... .. .. .. :..:: NP_001 MEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAKAPSAARSLPSASTS 100 110 120 130 140 150 180 190 pF1KE5 VASAEQDELSQRLARLRDQV :. ..:. ..: : NP_001 KATISDEEIERQLKALGVD 160 170 199 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 22:54:12 2016 done: Mon Nov 7 22:54:12 2016 Total Scan time: 5.000 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]