FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3037, 169 aa 1>>>pF1KE3037 169 - 169 aa - 169 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2358+/-0.000332; mu= 12.5731+/- 0.021 mean_var=61.7694+/-12.297, 0's: 0 Z-trim(115.0): 20 B-trim: 0 in 0/56 Lambda= 0.163188 statistics sampled from 25172 (25187) to 25172 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.695), E-opt: 0.2 (0.295), width: 16 Scan time: 5.210 The best scores are: opt bits E(85289) NP_919416 (OMIM: 192320) VIP peptides isoform 2 pr ( 169) 1089 264.5 5.8e-71 NP_003372 (OMIM: 192320) VIP peptides isoform 1 pr ( 170) 1077 261.7 4.2e-70 XP_005267192 (OMIM: 192320) PREDICTED: VIP peptide ( 168) 1072 260.5 9.3e-70 XP_006715625 (OMIM: 192320) PREDICTED: VIP peptide ( 169) 1060 257.7 6.6e-69 NP_001108 (OMIM: 102980) pituitary adenylate cycla ( 176) 221 60.1 2e-09 NP_001093203 (OMIM: 102980) pituitary adenylate cy ( 176) 221 60.1 2e-09 XP_005258138 (OMIM: 102980) PREDICTED: pituitary a ( 337) 221 60.3 3.5e-09 NP_002045 (OMIM: 138030) glucagon preproprotein [H ( 180) 161 46.0 3.6e-05 XP_011527090 (OMIM: 139190) PREDICTED: somatoliber ( 107) 148 42.9 0.00019 NP_001171660 (OMIM: 139190) somatoliberin isoform ( 107) 148 42.9 0.00019 XP_011527086 (OMIM: 139190) PREDICTED: somatoliber ( 108) 136 40.0 0.0014 NP_066567 (OMIM: 139190) somatoliberin isoform 1 p ( 108) 136 40.0 0.0014 >>NP_919416 (OMIM: 192320) VIP peptides isoform 2 prepro (169 aa) initn: 1089 init1: 1089 opt: 1089 Z-score: 1394.9 bits: 264.5 E(85289): 5.8e-71 Smith-Waterman score: 1089; 100.0% identity (100.0% similar) in 169 aa overlap (1-169:1-169) 10 20 30 40 50 60 pF1KE3 MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_919 MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSNISEDPVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_919 LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSNISEDPVP 70 80 90 100 110 120 130 140 150 160 pF1KE3 VKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK ::::::::::::::::::::::::::::::::::::::::::::::::: NP_919 VKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK 130 140 150 160 >>NP_003372 (OMIM: 192320) VIP peptides isoform 1 prepro (170 aa) initn: 835 init1: 718 opt: 1077 Z-score: 1379.6 bits: 261.7 E(85289): 4.2e-70 Smith-Waterman score: 1077; 99.4% identity (99.4% similar) in 170 aa overlap (1-169:1-170) 10 20 30 40 50 60 pF1KE3 MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVS-NISEDPV :::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::: NP_003 LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSSNISEDPV 70 80 90 100 110 120 120 130 140 150 160 pF1KE3 PVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK :::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK 130 140 150 160 170 >>XP_005267192 (OMIM: 192320) PREDICTED: VIP peptides is (168 aa) initn: 994 init1: 994 opt: 1072 Z-score: 1373.4 bits: 260.5 E(85289): 9.3e-70 Smith-Waterman score: 1072; 99.4% identity (99.4% similar) in 169 aa overlap (1-169:1-168) 10 20 30 40 50 60 pF1KE3 MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSNISEDPVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSNISEDPVP 70 80 90 100 110 120 130 140 150 160 pF1KE3 VKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK ::::::::::::::::::::::::::::::::::: ::::::::::::: XP_005 VKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRS-EGESPDFPEELEK 130 140 150 160 >>XP_006715625 (OMIM: 192320) PREDICTED: VIP peptides is (169 aa) initn: 778 init1: 778 opt: 1060 Z-score: 1358.0 bits: 257.7 E(85289): 6.6e-69 Smith-Waterman score: 1060; 98.8% identity (98.8% similar) in 170 aa overlap (1-169:1-169) 10 20 30 40 50 60 pF1KE3 MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVS-NISEDPV :::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::: XP_006 LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSSNISEDPV 70 80 90 100 110 120 120 130 140 150 160 pF1KE3 PVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK :::::::::::::::::::::::::::::::::::: ::::::::::::: XP_006 PVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRS-EGESPDFPEELEK 130 140 150 160 >>NP_001108 (OMIM: 102980) pituitary adenylate cyclase-a (176 aa) initn: 187 init1: 150 opt: 221 Z-score: 290.3 bits: 60.1 E(85289): 2e-09 Smith-Waterman score: 222; 36.3% identity (61.8% similar) in 157 aa overlap (10-154:9-161) 10 20 30 40 50 pF1KE3 MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKE-DID :.::. .. :.. . : : ..::. : : : : : . : . NP_001 MTMCSGARLALLVYGIIMHSSVYSSP---AAAGLRFPGIRPEEEAYGEDGNPLPDFDGS 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 MLQNALAENDTPYYDVS--RNARHAD---GVFTSDFSKLLGQLSAKKYLESLMGKRVSN- .: . ..: .. : : . : :... . :.: :::: :.:.::... :.. NP_001 EPPGAGSPASAPRAAAAWYRPAGRRDVAHGILNEAYRKVLDQLSAGKHLQSLVARGVGGS 60 70 80 90 100 110 120 130 140 150 160 pF1KE3 ----ISEDPVPV-KRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELE ..: :. :::::..:::.:.: :::::::::: ..: ::: NP_001 LGGGAGDDAEPLSKRHSDGIFTDSYSRYRKQMAVKKYLAAVL-GKRYKQRVKNKGRRIAY 120 130 140 150 160 170 pF1KE3 K NP_001 L >>NP_001093203 (OMIM: 102980) pituitary adenylate cyclas (176 aa) initn: 187 init1: 150 opt: 221 Z-score: 290.3 bits: 60.1 E(85289): 2e-09 Smith-Waterman score: 222; 36.3% identity (61.8% similar) in 157 aa overlap (10-154:9-161) 10 20 30 40 50 pF1KE3 MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKE-DID :.::. .. :.. . : : ..::. : : : : : . : . NP_001 MTMCSGARLALLVYGIIMHSSVYSSP---AAAGLRFPGIRPEEEAYGEDGNPLPDFDGS 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 MLQNALAENDTPYYDVS--RNARHAD---GVFTSDFSKLLGQLSAKKYLESLMGKRVSN- .: . ..: .. : : . : :... . :.: :::: :.:.::... :.. NP_001 EPPGAGSPASAPRAAAAWYRPAGRRDVAHGILNEAYRKVLDQLSAGKHLQSLVARGVGGS 60 70 80 90 100 110 120 130 140 150 160 pF1KE3 ----ISEDPVPV-KRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELE ..: :. :::::..:::.:.: :::::::::: ..: ::: NP_001 LGGGAGDDAEPLSKRHSDGIFTDSYSRYRKQMAVKKYLAAVL-GKRYKQRVKNKGRRIAY 120 130 140 150 160 170 pF1KE3 K NP_001 L >>XP_005258138 (OMIM: 102980) PREDICTED: pituitary adeny (337 aa) initn: 213 init1: 150 opt: 221 Z-score: 285.9 bits: 60.3 E(85289): 3.5e-09 Smith-Waterman score: 222; 36.3% identity (61.8% similar) in 157 aa overlap (10-154:170-322) 10 20 30 pF1KE3 MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGD :.::. .. :.. . : : ..::. XP_005 LEEALCPPSYLAALLAAGGVEGMTMCSGARLALLVYGIIMHSSVYSSP---AAAGLRFPG 140 150 160 170 180 190 40 50 60 70 80 90 pF1KE3 RIPFEGANEPDQVSLKE-DIDMLQNALAENDTPYYDVS--RNARHAD---GVFTSDFSKL : : : : : . : . .: . ..: .. : : . : :... . :. XP_005 IRPEEEAYGEDGNPLPDFDGSEPPGAGSPASAPRAAAAWYRPAGRRDVAHGILNEAYRKV 200 210 220 230 240 250 100 110 120 130 140 pF1KE3 LGQLSAKKYLESLMGKRVSN-----ISEDPVPV-KRHSDAVFTDNYTRLRKQMAVKKYLN : :::: :.:.::... :.. ..: :. :::::..:::.:.: :::::::::: XP_005 LDQLSAGKHLQSLVARGVGGSLGGGAGDDAEPLSKRHSDGIFTDSYSRYRKQMAVKKYLA 260 270 280 290 300 310 150 160 pF1KE3 SILNGKRSSEGESPDFPEELEK ..: ::: XP_005 AVL-GKRYKQRVKNKGRRIAYL 320 330 >>NP_002045 (OMIM: 138030) glucagon preproprotein [Homo (180 aa) initn: 188 init1: 89 opt: 161 Z-score: 213.8 bits: 46.0 E(85289): 3.6e-05 Smith-Waterman score: 161; 29.5% identity (64.8% similar) in 122 aa overlap (51-167:20-136) 30 40 50 60 70 pF1KE3 SQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDMLQNALAENDTPYYD---VSR : ::.. . .. : . : : ... NP_002 MKSIYFVAGLFVMLVQGSWQRSLQDTEEKSRSFSASQADPLSDPDQMNE 10 20 30 40 80 90 100 110 120 130 pF1KE3 NARHADGVFTSDFSKLLGQLSAKKYLESLMG-KRV-SNISEDPVPVKRHSDAVFTDNYTR . ::..:.::::.:: : . :. ... ::. :: .::.. .::....::.. . NP_002 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSS 50 60 70 80 90 100 140 150 160 pF1KE3 LRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK . .:.:... ...:. :. :::::. NP_002 YLEGQAAKEFIAWLVKGR----GRR-DFPEEVAIVEELGRRHADGSFSDEMNTILDNLAA 110 120 130 140 150 160 NP_002 RDFINWLIQTKITDRK 170 180 >>XP_011527090 (OMIM: 139190) PREDICTED: somatoliberin i (107 aa) initn: 141 init1: 104 opt: 148 Z-score: 200.7 bits: 42.9 E(85289): 0.00019 Smith-Waterman score: 148; 32.9% identity (72.0% similar) in 82 aa overlap (77-158:28-107) 50 60 70 80 90 100 pF1KE3 NEPDQVSLKEDIDMLQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESL : :.::..::... :.::::::.: :... XP_011 MPLWVFFFVILTLSNSSHCSPPPPLTLRMRRYADAIFTNSYRKVLGQLSARKLLQDI 10 20 30 40 50 110 120 130 140 150 160 pF1KE3 MGKRVSNISEDPVPVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEE :... .. ... : . : :.. .::: ... : ..:. .:.:.: XP_011 MSRQQGESNQERGARARLGRQV--DSMWAEQKQMELESILVALLQKHRNSQG 60 70 80 90 100 pF1KE3 LEK >>NP_001171660 (OMIM: 139190) somatoliberin isoform 2 pr (107 aa) initn: 141 init1: 104 opt: 148 Z-score: 200.7 bits: 42.9 E(85289): 0.00019 Smith-Waterman score: 148; 32.9% identity (72.0% similar) in 82 aa overlap (77-158:28-107) 50 60 70 80 90 100 pF1KE3 NEPDQVSLKEDIDMLQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESL : :.::..::... :.::::::.: :... NP_001 MPLWVFFFVILTLSNSSHCSPPPPLTLRMRRYADAIFTNSYRKVLGQLSARKLLQDI 10 20 30 40 50 110 120 130 140 150 160 pF1KE3 MGKRVSNISEDPVPVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEE :... .. ... : . : :.. .::: ... : ..:. .:.:.: NP_001 MSRQQGESNQERGARARLGRQV--DSMWAEQKQMELESILVALLQKHRNSQG 60 70 80 90 100 pF1KE3 LEK 169 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 04:56:17 2016 done: Sun Nov 6 04:56:18 2016 Total Scan time: 5.210 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]