FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4412, 425 aa 1>>>pF1KE4412 425 - 425 aa - 425 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4315+/-0.000468; mu= 16.2132+/- 0.029 mean_var=62.8359+/-12.833, 0's: 0 Z-trim(108.5): 59 B-trim: 277 in 1/51 Lambda= 0.161797 statistics sampled from 16591 (16650) to 16591 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.552), E-opt: 0.2 (0.195), width: 16 Scan time: 5.800 The best scores are: opt bits E(85289) NP_001287816 (OMIM: 607309) AP-1 complex subunit m ( 425) 2744 649.7 4e-186 NP_005489 (OMIM: 607309) AP-1 complex subunit mu-2 ( 423) 2709 641.5 1.2e-183 NP_115882 (OMIM: 603535) AP-1 complex subunit mu-1 ( 423) 2273 539.8 5e-153 XP_016882910 (OMIM: 603535) PREDICTED: AP-1 comple ( 397) 2149 510.8 2.4e-144 XP_016882909 (OMIM: 603535) PREDICTED: AP-1 comple ( 409) 1321 317.5 3.8e-86 NP_001123996 (OMIM: 603535) AP-1 complex subunit m ( 435) 1321 317.6 4e-86 NP_001020376 (OMIM: 601024) AP-2 complex subunit m ( 433) 1116 269.7 1e-71 NP_004059 (OMIM: 601024) AP-2 complex subunit mu i ( 435) 769 188.7 2.5e-47 NP_001298127 (OMIM: 601024) AP-2 complex subunit m ( 460) 769 188.7 2.6e-47 NP_001307193 (OMIM: 610366) AP-3 complex subunit m ( 418) 525 131.7 3.3e-30 NP_036227 (OMIM: 610366) AP-3 complex subunit mu-1 ( 418) 525 131.7 3.3e-30 NP_996895 (OMIM: 610366) AP-3 complex subunit mu-1 ( 418) 525 131.7 3.3e-30 NP_001307192 (OMIM: 610366) AP-3 complex subunit m ( 418) 525 131.7 3.3e-30 NP_006794 (OMIM: 610469) AP-3 complex subunit mu-2 ( 418) 490 123.6 9.6e-28 NP_001127768 (OMIM: 610469) AP-3 complex subunit m ( 418) 490 123.6 9.6e-28 XP_016868466 (OMIM: 610469) PREDICTED: AP-3 comple ( 418) 490 123.6 9.6e-28 NP_001307194 (OMIM: 610366) AP-3 complex subunit m ( 364) 331 86.4 1.3e-16 XP_016868467 (OMIM: 610469) PREDICTED: AP-3 comple ( 303) 326 85.2 2.4e-16 XP_016868468 (OMIM: 610469) PREDICTED: AP-3 comple ( 303) 326 85.2 2.4e-16 XP_016868279 (OMIM: 602296,612936) PREDICTED: AP-4 ( 284) 324 84.8 3.2e-16 XP_005250747 (OMIM: 602296,612936) PREDICTED: AP-4 ( 385) 324 84.8 4.1e-16 NP_004713 (OMIM: 602296,612936) AP-4 complex subun ( 453) 273 72.9 1.8e-12 XP_006716238 (OMIM: 602296,612936) PREDICTED: AP-4 ( 419) 260 69.9 1.4e-11 XP_005250746 (OMIM: 602296,612936) PREDICTED: AP-4 ( 460) 260 69.9 1.5e-11 XP_011514987 (OMIM: 602296,612936) PREDICTED: AP-4 ( 460) 260 69.9 1.5e-11 XP_006720342 (OMIM: 608467) PREDICTED: stonin-2 is ( 898) 204 56.9 2.3e-07 NP_149095 (OMIM: 608467) stonin-2 isoform 1 [Homo ( 905) 204 56.9 2.4e-07 NP_001243359 (OMIM: 608467) stonin-2 isoform 2 [Ho ( 920) 204 56.9 2.4e-07 XP_011535544 (OMIM: 608467) PREDICTED: stonin-2 is ( 955) 204 57.0 2.5e-07 XP_011535543 (OMIM: 608467) PREDICTED: stonin-2 is ( 962) 204 57.0 2.5e-07 XP_011535542 (OMIM: 608467) PREDICTED: stonin-2 is ( 977) 204 57.0 2.5e-07 XP_016868280 (OMIM: 602296,612936) PREDICTED: AP-4 ( 228) 173 49.5 1.1e-05 NP_001185524 (OMIM: 605357) stonin-1 [Homo sapiens ( 735) 171 49.2 4.1e-05 NP_006864 (OMIM: 605357) stonin-1 [Homo sapiens] ( 735) 171 49.2 4.1e-05 XP_006720259 (OMIM: 614368) PREDICTED: AP-5 comple ( 387) 148 43.7 0.00096 NP_060699 (OMIM: 614368) AP-5 complex subunit mu-1 ( 490) 148 43.8 0.0012 XP_011535242 (OMIM: 614368) PREDICTED: AP-5 comple ( 504) 148 43.8 0.0012 >>NP_001287816 (OMIM: 607309) AP-1 complex subunit mu-2 (425 aa) initn: 2744 init1: 2744 opt: 2744 Z-score: 3462.4 bits: 649.7 E(85289): 4e-186 Smith-Waterman score: 2744; 99.8% identity (99.8% similar) in 425 aa overlap (1-425:1-425) 10 20 30 40 50 60 pF1KE4 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 GFPQTTDSKILQEYITQQSNKLETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFPQTTDSKILQEYITQQSNKLETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 LLVNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTGLSGSKNKSVELEDVKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLVNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTGLSGSKNKSVELEDVKF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 HQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSHSRVEIMVKAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSHSRVEIMVKAK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 GQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIKSFPGGKEYLMRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIKSFPGGKEYLMRA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 HFGLPRVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQALPWVRYITQSGDY ::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HFGLPSVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQALPWVRYITQSGDY 370 380 390 400 410 420 pF1KE4 QLRTS ::::: NP_001 QLRTS >>NP_005489 (OMIM: 607309) AP-1 complex subunit mu-2 iso (423 aa) initn: 1430 init1: 1430 opt: 2709 Z-score: 3418.3 bits: 641.5 E(85289): 1.2e-183 Smith-Waterman score: 2709; 99.1% identity (99.1% similar) in 425 aa overlap (1-425:1-423) 10 20 30 40 50 60 pF1KE4 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 GFPQTTDSKILQEYITQQSNKLETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GFPQTTDSKILQEYITQQSNKLETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 LLVNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTGLSGSKNKSVELEDVKF :::::::::::::::::::::::::::::::::::::::::::: : :::::::::::: NP_005 LLVNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTGRS--KNKSVELEDVKF 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 HQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSHSRVEIMVKAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 HQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSHSRVEIMVKAK 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE4 GQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIKSFPGGKEYLMRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIKSFPGGKEYLMRA 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 HFGLPRVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQALPWVRYITQSGDY ::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 HFGLPSVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQALPWVRYITQSGDY 360 370 380 390 400 410 pF1KE4 QLRTS ::::: NP_005 QLRTS 420 >>NP_115882 (OMIM: 603535) AP-1 complex subunit mu-1 iso (423 aa) initn: 1175 init1: 1175 opt: 2273 Z-score: 2868.3 bits: 539.8 E(85289): 5e-153 Smith-Waterman score: 2273; 79.0% identity (94.3% similar) in 424 aa overlap (1-424:1-422) 10 20 30 40 50 60 pF1KE4 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI ::::::..::.::: :: :::.::: ::..:::::.:...:::: :.:.:.:: :.:.:: NP_115 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF ::.:::::::..::: .:::.:::::...:: :::::::::::::::::.:::::::::: NP_115 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 GFPQTTDSKILQEYITQQSNKLETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVN :.:::::::::::::::...::::: : : :::::::::::::::.:::::.::::::: NP_115 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 LLVNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTGLSGSKNKSVELEDVKF :::.:::.:: :::::.::..:::::::::::::::.:::. :: . :.:::::::::: NP_115 LLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRG--KSKSVELEDVKF 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 HQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSHSRVEIMVKAK :::::::::.::::::::::::.::::::::.:.::::::::::::: ::::.: :.::: NP_115 HQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIEYMIKAK 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE4 GQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIKSFPGGKEYLMRA .:::..:.::.::: .:::.:::::.:::.:::.:.::: . ..:::::::::::::::: NP_115 SQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSFPGGKEYLMRA 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 HFGLPRVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQALPWVRYITQSGDY ::::: :: :. ::.:::.:::::::::.:::::::.:::::::::::::::::::.::: NP_115 HFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGDY 360 370 380 390 400 410 pF1KE4 QLRTS :::: NP_115 QLRTQ 420 >>XP_016882910 (OMIM: 603535) PREDICTED: AP-1 complex su (397 aa) initn: 1125 init1: 1125 opt: 2149 Z-score: 2712.3 bits: 510.8 E(85289): 2.4e-144 Smith-Waterman score: 2149; 79.4% identity (94.7% similar) in 398 aa overlap (27-424:1-396) 10 20 30 40 50 60 pF1KE4 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI ::..:::::.:...:::: :.:.:.:: :.:.:: XP_016 MSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI 10 20 30 70 80 90 100 110 120 pF1KE4 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF ::.:::::::..::: .:::.:::::...:: :::::::::::::::::.:::::::::: XP_016 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE4 GFPQTTDSKILQEYITQQSNKLETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVN :.:::::::::::::::...::::: : : :::::::::::::::.:::::.::::::: XP_016 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE4 LLVNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTGLSGSKNKSVELEDVKF :::.:::.:: :::::.::..:::::::::::::::.:::. :: . :.:::::::::: XP_016 LLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRG--KSKSVELEDVKF 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE4 HQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSHSRVEIMVKAK :::::::::.::::::::::::.::::::::.:.::::::::::::: ::::.: :.::: XP_016 HQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIEYMIKAK 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE4 GQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIKSFPGGKEYLMRA .:::..:.::.::: .:::.:::::.:::.:::.:.::: . ..:::::::::::::::: XP_016 SQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSFPGGKEYLMRA 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE4 HFGLPRVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQALPWVRYITQSGDY ::::: :: :. ::.:::.:::::::::.:::::::.:::::::::::::::::::.::: XP_016 HFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGDY 340 350 360 370 380 390 pF1KE4 QLRTS :::: XP_016 QLRTQ >>XP_016882909 (OMIM: 603535) PREDICTED: AP-1 complex su (409 aa) initn: 1940 init1: 1125 opt: 1321 Z-score: 1667.6 bits: 317.5 E(85289): 3.8e-86 Smith-Waterman score: 2115; 77.1% identity (92.0% similar) in 410 aa overlap (27-424:1-408) 10 20 30 40 50 60 pF1KE4 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI ::..:::::.:...:::: :.:.:.:: :.:.:: XP_016 MSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI 10 20 30 70 80 90 100 110 120 pF1KE4 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF ::.:::::::..::: .:::.:::::...:: :::::::::::::::::.:::::::::: XP_016 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE4 GFPQTTDSKILQEYITQQSNKLETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVN :.:::::::::::::::...::::: : : :::::::::::::::.:::::.::::::: XP_016 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN 100 110 120 130 140 150 190 200 210 220 pF1KE4 LL------------VNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTGLSGS :: :.:::.:: :::::.::..:::::::::::::::.:::. :: . XP_016 LLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRG-- 160 170 180 190 200 210 230 240 250 260 270 280 pF1KE4 KNKSVELEDVKFHQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKF :.:::::::::::::::::::.::::::::::::.::::::::.:.::::::::::::: XP_016 KSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKH 220 230 240 250 260 270 290 300 310 320 330 340 pF1KE4 SHSRVEIMVKAKGQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIK ::::.: :.:::.:::..:.::.::: .:::.:::::.:::.:::.:.::: . ..:::: XP_016 SHSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIK 280 290 300 310 320 330 350 360 370 380 390 400 pF1KE4 SFPGGKEYLMRAHFGLPRVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQAL ::::::::::::::::: :: :. ::.:::.:::::::::.:::::::.::::::::::: XP_016 SFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQAL 340 350 360 370 380 390 410 420 pF1KE4 PWVRYITQSGDYQLRTS ::::::::.::::::: XP_016 PWVRYITQNGDYQLRTQ 400 >>NP_001123996 (OMIM: 603535) AP-1 complex subunit mu-1 (435 aa) initn: 2064 init1: 1125 opt: 1321 Z-score: 1667.1 bits: 317.6 E(85289): 4e-86 Smith-Waterman score: 2239; 76.8% identity (91.7% similar) in 436 aa overlap (1-424:1-434) 10 20 30 40 50 60 pF1KE4 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI ::::::..::.::: :: :::.::: ::..:::::.:...:::: :.:.:.:: :.:.:: NP_001 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF ::.:::::::..::: .:::.:::::...:: :::::::::::::::::.:::::::::: NP_001 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 GFPQTTDSKILQEYITQQSNKLETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVN :.:::::::::::::::...::::: : : :::::::::::::::.:::::.::::::: NP_001 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN 130 140 150 160 170 180 190 200 210 220 pF1KE4 LL------------VNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTGLSGS :: :.:::.:: :::::.::..:::::::::::::::.:::. :: . NP_001 LLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRG-- 190 200 210 220 230 230 240 250 260 270 280 pF1KE4 KNKSVELEDVKFHQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKF :.:::::::::::::::::::.::::::::::::.::::::::.:.::::::::::::: NP_001 KSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKH 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE4 SHSRVEIMVKAKGQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIK ::::.: :.:::.:::..:.::.::: .:::.:::::.:::.:::.:.::: . ..:::: NP_001 SHSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIK 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE4 SFPGGKEYLMRAHFGLPRVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQAL ::::::::::::::::: :: :. ::.:::.:::::::::.:::::::.::::::::::: NP_001 SFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQAL 360 370 380 390 400 410 410 420 pF1KE4 PWVRYITQSGDYQLRTS ::::::::.::::::: NP_001 PWVRYITQNGDYQLRTQ 420 430 >>NP_001020376 (OMIM: 601024) AP-2 complex subunit mu is (433 aa) initn: 1064 init1: 380 opt: 1116 Z-score: 1408.6 bits: 269.7 E(85289): 1e-71 Smith-Waterman score: 1116; 39.2% identity (74.5% similar) in 431 aa overlap (6-423:5-432) 10 20 30 40 50 60 pF1KE4 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI .:: . ::. :::: :. :.. . .. : ... ... . .:. . ... :. . NP_001 MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQ-VRSPVTNIARTSFFHV 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF :.::..:.:.:..:.::..:. :::: .:. :: .. ::.:..:::..::::::..:: NP_001 KRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDF 60 70 80 90 100 110 130 140 150 160 170 pF1KE4 GFPQTTDSKILQEYITQQSNKLETG--KSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIES :.::.... :. .::::. : .: .:.. ::. ..:: :::::..::.:.::.:: NP_001 GYPQNSETGALKTFITQQGIKSQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLES 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 VNLLVNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTG------LSGSKNKS ::::.. .:.:: ... : . .: .:::::: ..:.::....: : : : ..: NP_001 VNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADETSKSGKQS 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 VELEDVKFHQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSHSR . ..: ::::::::.::..:.::::::::.:::: :: . .. . . .... .... NP_001 IAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGRTK 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 VEIMVKAKGQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIKSFPG .:. : :..:: . .:. .:. .:.: .... . :.::: .:...:.:: . : NP_001 LEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAG 300 310 320 330 340 350 360 370 380 390 400 pF1KE4 GKEYLMRAHFGL-PRVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEK----SGYQA :: . :.. : : .:.. .::::...::.: :. ::..:::.:..: : ... NP_001 MKESQISAEIELLPTNDKKKW-ARPPISMNFEVP-FAPSGLKVRYLKVFEPKLNYSDHDV 360 370 380 390 400 410 410 420 pF1KE4 LPWVRYITQSGDYQLRTS . ::::: .:: :. : NP_001 IKWVRYIGRSGIYETRC 420 430 >>NP_004059 (OMIM: 601024) AP-2 complex subunit mu isofo (435 aa) initn: 1087 init1: 380 opt: 769 Z-score: 970.8 bits: 188.7 E(85289): 2.5e-47 Smith-Waterman score: 1106; 38.8% identity (73.9% similar) in 433 aa overlap (6-423:5-434) 10 20 30 40 50 60 pF1KE4 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI .:: . ::. :::: :. :.. . .. : ... ... . .:. . ... :. . NP_004 MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQ-VRSPVTNIARTSFFHV 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF :.::..:.:.:..:.::..:. :::: .:. :: .. ::.:..:::..::::::..:: NP_004 KRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDF 60 70 80 90 100 110 130 140 150 160 170 pF1KE4 GFPQTTDSKILQEYITQQSNK----LETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVI :.::.... :. .::::. : . .:.. ::. ..:: :::::..::.:.::. NP_004 GYPQNSETGALKTFITQQGIKSQHQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 ESVNLLVNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTG------LSGSKN ::::::.. .:.:: ... : . .: .:::::: ..:.::....: : : : . NP_004 ESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADETSKSGK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 KSVELEDVKFHQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSH .:. ..: ::::::::.::..:.::::::::.:::: :: . .. . . .... .. NP_004 QSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGR 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 SRVEIMVKAKGQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIKSF ...:. : :..:: . .:. .:. .:.: .... . :.::: .:...:.:: . NP_004 TKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRM 300 310 320 330 340 350 360 370 380 390 400 pF1KE4 PGGKEYLMRAHFGL-PRVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEK----SGY : :: . :.. : : .:.. .::::...::.: :. ::..:::.:..: : . NP_004 AGMKESQISAEIELLPTNDKKKW-ARPPISMNFEVP-FAPSGLKVRYLKVFEPKLNYSDH 360 370 380 390 400 410 410 420 pF1KE4 QALPWVRYITQSGDYQLRTS ... ::::: .:: :. : NP_004 DVIKWVRYIGRSGIYETRC 420 430 >>NP_001298127 (OMIM: 601024) AP-2 complex subunit mu is (460 aa) initn: 1077 init1: 380 opt: 769 Z-score: 970.4 bits: 188.7 E(85289): 2.6e-47 Smith-Waterman score: 1048; 40.1% identity (74.7% similar) in 392 aa overlap (47-423:70-459) 20 30 40 50 60 70 pF1KE4 ISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWIKHSNLYLVATTSKNAN .:. . ... :. .:.::..:.:.:..:.: NP_001 PFPGEWLEANRRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHVKRSNIWLAAVTKQNVN 40 50 60 70 80 90 80 90 100 110 120 130 pF1KE4 ASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDFGFPQTTDSKILQEYIT :..:. :::: .:. :: .. ::.:..:::..::::::..:::.::.... :. .:: NP_001 AAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFGYPQNSETGALKTFIT 100 110 120 130 140 150 140 150 160 170 180 190 pF1KE4 QQSNK----LETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVNLLVNANGSVLLS ::. : . .:.. ::. ..:: :::::..::.:.::.::::::.. .:.:: . NP_001 QQGIKSQHQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLESVNLLMSPQGQVLSA 160 170 180 190 200 210 200 210 220 230 240 pF1KE4 EIVGTIKLKVFLSGMPELRLGLNDRVLFELTG------LSGSKNKSVELEDVKFHQCVRL .. : . .: .:::::: ..:.::....: : : : ..:. ..: ::::::: NP_001 HVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADETSKSGKQSIAIDDCTFHQCVRL 220 230 240 250 260 270 250 260 270 280 290 300 pF1KE4 SRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSHSRVEIMVKAKGQFKKQ :.::..:.::::::::.:::: :: . .. . . .... .....:. : :..:: . NP_001 SKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGRTKLEVKVVIKSNFKPS 280 290 300 310 320 330 310 320 330 340 350 360 pF1KE4 SVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIKSFPGGKEYLMRAHFGL-P .:. .:. .:.: .... . :.::: .:...:.:: . : :: . :.. : : NP_001 LLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGMKESQISAEIELLP 340 350 360 370 380 390 370 380 390 400 410 420 pF1KE4 RVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEK----SGYQALPWVRYITQSGDYQ .:.. .::::...::.: :. ::..:::.:..: : .... ::::: .:: :. NP_001 TNDKKKW-ARPPISMNFEVP-FAPSGLKVRYLKVFEPKLNYSDHDVIKWVRYIGRSGIYE 400 410 420 430 440 450 pF1KE4 LRTS : NP_001 TRC 460 >>NP_001307193 (OMIM: 610366) AP-3 complex subunit mu-1 (418 aa) initn: 522 init1: 190 opt: 525 Z-score: 663.2 bits: 131.7 E(85289): 3.3e-30 Smith-Waterman score: 697; 29.5% identity (64.2% similar) in 441 aa overlap (5-424:4-418) 10 20 30 40 50 60 pF1KE4 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI ..:... .: .. ...:. :..: ..:. . . . :..: . ... : NP_001 MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISI 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF ...:..:.. . .. .: ::... ..: .:: : : .:.:: :::::::.:..: NP_001 YRDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDN 60 70 80 90 100 110 130 140 150 160 170 pF1KE4 GFPQTTDSKILQEYITQQS------NKLETGKSRV----PPTVTNAVSWRSEGIKYKKNE ::: .:.:.::.: : . :.. ::.: : : . . :: :.:: .:: NP_001 GFPLATESNILKELIKPPTILRSVVNSI-TGSSNVGDTLPTGQLSNIPWRRAGVKYTNNE 120 130 140 150 160 170 180 190 200 210 220 pF1KE4 VFIDVIESVNLLVNANGSVLLSEIVGTIKLKVFLSGMPELRLG-LNDRVLFELTGLSGSK ...::.: .. ... .::....:: :.: . :::::.: :. .: :.: NP_001 AYFDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLL---------- 180 190 200 210 220 230 240 250 260 270 280 pF1KE4 NKSVELEDVKFHQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQ--VKPLIWIESVI-- .::.:: :.:..:....:..:::::::.:.:.:::.:.: : .... : NP_001 ------DDVSFHPCIRFKRWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISF 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE4 -EKFSHSRVEIMVKAKGQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVI :. : .: .: . : .. : . .:. ..: .:. . . . . :: . : .:. NP_001 KENSSCGRFDITIGPKQNMGK--TIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLT 290 300 310 320 330 340 350 360 370 380 390 pF1KE4 WSI-----KSFPGGKEYLMRAHFGLPRVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKI :.. ...:. : :. . : :. :.. : ....:.: ...::..: . . NP_001 WDVGKITPQKLPSLKG-LVNLQSGAPKPEEN-----PSLNIQFKIQQLAISGLKVNRLDM 350 360 370 380 390 400 410 420 pF1KE4 IEKSGYQALPWVRYITQSGDYQLRTS .. :. . :.:.:..: .:.:: NP_001 YGEK-YKPFKGVKYVTKAGKFQVRT 400 410 425 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 01:16:49 2016 done: Sun Nov 6 01:16:50 2016 Total Scan time: 5.800 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]