FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2722, 300 aa 1>>>pF1KE2722 300 - 300 aa - 300 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4682+/-0.000893; mu= 14.6339+/- 0.053 mean_var=63.4799+/-12.823, 0's: 0 Z-trim(106.1): 83 B-trim: 507 in 1/49 Lambda= 0.160974 statistics sampled from 8727 (8812) to 8727 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.656), E-opt: 0.2 (0.271), width: 16 Scan time: 1.080 The best scores are: opt bits E(32554) CCDS41927.1 DHRS2 gene_id:10202|Hs108|chr14 ( 300) 1952 461.9 2.7e-130 CCDS9604.1 DHRS2 gene_id:10202|Hs108|chr14 ( 280) 1437 342.2 2.6e-94 CCDS9605.1 DHRS4 gene_id:10901|Hs108|chr14 ( 278) 896 216.6 1.7e-56 CCDS9606.2 DHRS4L2 gene_id:317749|Hs108|chr14 ( 232) 816 198.0 5.7e-51 CCDS61409.1 DHRS4 gene_id:10901|Hs108|chr14 ( 192) 565 139.7 1.7e-33 CCDS61408.1 DHRS4 gene_id:10901|Hs108|chr14 ( 188) 563 139.2 2.3e-33 CCDS61410.1 DHRS4 gene_id:10901|Hs108|chr14 ( 244) 453 113.7 1.4e-25 CCDS61411.1 DHRS4 gene_id:10901|Hs108|chr14 ( 199) 447 112.3 3.1e-25 CCDS61412.1 DHRS4 gene_id:10901|Hs108|chr14 ( 158) 441 110.8 6.6e-25 CCDS33375.1 PECR gene_id:55825|Hs108|chr2 ( 303) 317 82.2 5.5e-16 CCDS12736.1 HSD17B14 gene_id:51171|Hs108|chr19 ( 270) 303 78.9 4.7e-15 CCDS3812.1 CBR4 gene_id:84869|Hs108|chr4 ( 237) 299 77.9 8e-15 CCDS3663.1 BDH2 gene_id:56898|Hs108|chr4 ( 245) 277 72.8 2.9e-13 CCDS12223.2 RDH8 gene_id:50700|Hs108|chr19 ( 331) 276 72.6 4.4e-13 CCDS11315.2 DHRS11 gene_id:79154|Hs108|chr17 ( 260) 272 71.7 6.7e-13 CCDS11799.1 DCXR gene_id:51181|Hs108|chr17 ( 244) 264 69.8 2.3e-12 CCDS1489.1 HSD11B1 gene_id:3290|Hs108|chr1 ( 292) 260 68.9 5.1e-12 CCDS10409.1 DECR2 gene_id:26063|Hs108|chr16 ( 292) 260 68.9 5.1e-12 CCDS3821.1 HPGD gene_id:3248|Hs108|chr4 ( 266) 259 68.7 5.6e-12 CCDS10942.1 HSDL1 gene_id:83693|Hs108|chr16 ( 330) 250 66.6 2.9e-11 >>CCDS41927.1 DHRS2 gene_id:10202|Hs108|chr14 (300 aa) initn: 1952 init1: 1952 opt: 1952 Z-score: 2452.7 bits: 461.9 E(32554): 2.7e-130 Smith-Waterman score: 1952; 100.0% identity (100.0% similar) in 300 aa overlap (1-300:1-300) 10 20 30 40 50 60 pF1KE2 MLSAVARGYQGWFHPCARLSVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 MLSAVARGYQGWFHPCARLSVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 AHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 AHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 AGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRGAVILVSSIAAYNPVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 AGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRGAVILVSSIAAYNPVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 ALGVYNVSKTALLGLTRTLALELAPKDIRVNCVVPGIIKTDFSKVVRIGFMGMSLSGRTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 ALGVYNVSKTALLGLTRTLALELAPKDIRVNCVVPGIIKTDFSKVVRIGFMGMSLSGRTS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 RNIISCRGLGSQRTVQESCPSCALQMPATSTGRTLRWQATPLGSERSGGGCVAVVPGPGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 RNIISCRGLGSQRTVQESCPSCALQMPATSTGRTLRWQATPLGSERSGGGCVAVVPGPGA 250 260 270 280 290 300 >>CCDS9604.1 DHRS2 gene_id:10202|Hs108|chr14 (280 aa) initn: 1437 init1: 1437 opt: 1437 Z-score: 1806.7 bits: 342.2 E(32554): 2.6e-94 Smith-Waterman score: 1437; 100.0% identity (100.0% similar) in 225 aa overlap (1-225:1-225) 10 20 30 40 50 60 pF1KE2 MLSAVARGYQGWFHPCARLSVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS96 MLSAVARGYQGWFHPCARLSVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 AHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS96 AHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 AGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRGAVILVSSIAAYNPVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS96 AGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRGAVILVSSIAAYNPVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 ALGVYNVSKTALLGLTRTLALELAPKDIRVNCVVPGIIKTDFSKVVRIGFMGMSLSGRTS ::::::::::::::::::::::::::::::::::::::::::::: CCDS96 ALGVYNVSKTALLGLTRTLALELAPKDIRVNCVVPGIIKTDFSKVFHGNESLWKNFKEHH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 RNIISCRGLGSQRTVQESCPSCALQMPATSTGRTLRWQATPLGSERSGGGCVAVVPGPGA CCDS96 QLQRIGESEDCAGIVSFLCSPDASYVNGENIAVAGYSTRL 250 260 270 280 >>CCDS9605.1 DHRS4 gene_id:10901|Hs108|chr14 (278 aa) initn: 883 init1: 647 opt: 896 Z-score: 1127.8 bits: 216.6 E(32554): 1.7e-56 Smith-Waterman score: 896; 63.0% identity (87.7% similar) in 219 aa overlap (11-226:5-223) 10 20 30 40 50 pF1KE2 MLSAVARGYQGWFHPCARL--SVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLAR : . ::: ::::.:.:. :. :::.::.::.::.:::::::::::. CCDS96 MHKAGLLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQ 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 DGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLV ::::::.:::::::::.:.: ::::::::.: :::::::::::.::: :.. ::.:.:: CCDS96 DGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVATAVKLHGGIDILV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 CSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRG-AVILVSSIAAYN .:.:::. :: . ..:..::: :..:::.:::. . ..: ::.: : .:..::::::.. CCDS96 SNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 PVVALGVYNVSKTALLGLTRTLALELAPKDIRVNCVVPGIIKTDFSKVVRIGFMGMSLSG : ... ::::::::::::.:::.::::..:::::..::.:::.::... CCDS96 PSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 RTSRNIISCRGLGSQRTVQESCPSCALQMPATSTGRTLRWQATPLGSERSGGGCVAVVPG CCDS96 ETLRIRRLGEPEDCAGIVSFLCSEDASYITGETVVVGGGTPSRL 240 250 260 270 >>CCDS9606.2 DHRS4L2 gene_id:317749|Hs108|chr14 (232 aa) initn: 801 init1: 628 opt: 816 Z-score: 1028.6 bits: 198.0 E(32554): 5.7e-51 Smith-Waterman score: 816; 56.9% identity (81.0% similar) in 232 aa overlap (8-238:8-230) 10 20 30 40 50 60 pF1KE2 MLSAVARGYQGWFHPCARLSVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDG : .: :: ::::.:. . :. :.:.::.::.::.:::::::::::.: CCDS96 MQMARLLGLCAW----ARKSVRMASSRMTRRDPLTNKVALVTASTDGIGFAIARRLAQDR 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 AHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCS ::::.:::::::::.:.: ::::::::.: :::::::::::.::: :.. ::.:.:: . CCDS96 AHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVAMAVKLHGGIDILVSN 60 70 80 90 100 110 130 140 150 160 170 pF1KE2 AGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRG-AVILVSSIAAYNPV :.:::. :: . ..:..::: :..:::.:::. . ..: ::.: : .:..::::::..: CCDS96 AAVNPFFGSLMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 VALGVYNVSKTALLGLTRTLALELAPKDIRVNCVVPGIIKTDFSKVVRIGFMGMSLSGRT ... :::::::::::. :::.::::..::::: .. :.:... : : . . : CCDS96 PGFSPYNVSKTALLGLNNTLAIELAPRNIRVNC-----LHLDLSRLASAGCSGWTRKKRK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 SRNIISCRGLGSQRTVQESCPSCALQMPATSTGRTLRWQATPLGSERSGGGCVAVVPGPG CCDS96 A >>CCDS61409.1 DHRS4 gene_id:10901|Hs108|chr14 (192 aa) initn: 555 init1: 555 opt: 565 Z-score: 714.9 bits: 139.7 E(32554): 1.7e-33 Smith-Waterman score: 565; 65.4% identity (86.5% similar) in 133 aa overlap (11-141:5-137) 10 20 30 40 50 pF1KE2 MLSAVARGYQGWFHPCARL--SVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLAR : . ::: ::::.:.:. :. :::.::.::.::.:::::::::::. CCDS61 MHKAGLLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQ 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 DGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLV ::::::.:::::::::.:.: ::::::::.: :::::::::::.::: :.. ::.:.:: CCDS61 DGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVATAVKLHGGIDILV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 CSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRGAVILVSSIAAYNP .:.:::. :: . ..:..:::. CCDS61 SNAAVNPFFGSIMDVTEEVWDKLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDA 120 130 140 150 160 170 >>CCDS61408.1 DHRS4 gene_id:10901|Hs108|chr14 (188 aa) initn: 553 init1: 553 opt: 563 Z-score: 712.5 bits: 139.2 E(32554): 2.3e-33 Smith-Waterman score: 563; 65.9% identity (86.4% similar) in 132 aa overlap (11-140:5-136) 10 20 30 40 50 pF1KE2 MLSAVARGYQGWFHPCARL--SVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLAR : . ::: ::::.:.:. :. :::.::.::.::.:::::::::::. CCDS61 MHKAGLLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQ 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 DGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLV ::::::.:::::::::.:.: ::::::::.: :::::::::::.::: :.. ::.:.:: CCDS61 DGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVATAVKLHGGIDILV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 CSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRGAVILVSSIAAYNP .:.:::. :: . ..:..::: CCDS61 SNAAVNPFFGSIMDVTEEVWDKRRLSGDRVFHSSLQSISSLDGQGKRGKHERNPADKKVR 120 130 140 150 160 170 >>CCDS61410.1 DHRS4 gene_id:10901|Hs108|chr14 (244 aa) initn: 745 init1: 437 opt: 453 Z-score: 572.7 bits: 113.7 E(32554): 1.4e-25 Smith-Waterman score: 698; 55.7% identity (75.3% similar) in 219 aa overlap (11-226:5-189) 10 20 30 40 50 pF1KE2 MLSAVARGYQGWFHPCARL--SVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLAR : . ::: ::::.:.:. :. :::.::.::.::.:::::::::::. CCDS61 MHKAGLLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQ 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 DGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLV ::::::.:::::::::.:.: ::::::::.: :::::::::::.::: .:. CCDS61 DGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVATTLD--------- 60 70 80 90 100 120 130 140 150 160 170 pF1KE2 CSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRG-AVILVSSIAAYN .:::.:::. . ..: ::.: : .:..::::::.. CCDS61 -------------------------INVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFS 110 120 130 140 180 190 200 210 220 230 pF1KE2 PVVALGVYNVSKTALLGLTRTLALELAPKDIRVNCVVPGIIKTDFSKVVRIGFMGMSLSG : ... ::::::::::::.:::.::::..:::::..::.:::.::... CCDS61 PSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMK 150 160 170 180 190 200 240 250 260 270 280 290 pF1KE2 RTSRNIISCRGLGSQRTVQESCPSCALQMPATSTGRTLRWQATPLGSERSGGGCVAVVPG CCDS61 ETLRIRRLGEPEDCAGIVSFLCSEDASYITGETVVVGGGTPSRL 210 220 230 240 >>CCDS61411.1 DHRS4 gene_id:10901|Hs108|chr14 (199 aa) initn: 540 init1: 437 opt: 447 Z-score: 566.5 bits: 112.3 E(32554): 3.1e-25 Smith-Waterman score: 493; 53.2% identity (70.2% similar) in 171 aa overlap (11-178:5-141) 10 20 30 40 50 pF1KE2 MLSAVARGYQGWFHPCARL--SVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLAR : . ::: ::::.:.:. :. :::.::.::.::.:::::::::::. CCDS61 MHKAGLLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQ 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 DGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLV ::::::.:::::::::.:.: ::::::::.: :::::::::::.::: .:. CCDS61 DGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVATTLD--------- 60 70 80 90 100 120 130 140 150 160 170 pF1KE2 CSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRG-AVILVSSIAAYN .:::.:::. . ..: ::.: : .:..::::::.. CCDS61 -------------------------INVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFS 110 120 130 140 180 190 200 210 220 230 pF1KE2 PVVALGVYNVSKTALLGLTRTLALELAPKDIRVNCVVPGIIKTDFSKVVRIGFMGMSLSG : CCDS61 PSPLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYITGETVVVGGGTPSRL 150 160 170 180 190 >>CCDS61412.1 DHRS4 gene_id:10901|Hs108|chr14 (158 aa) initn: 431 init1: 431 opt: 441 Z-score: 560.6 bits: 110.8 E(32554): 6.6e-25 Smith-Waterman score: 441; 73.2% identity (88.7% similar) in 97 aa overlap (11-105:5-101) 10 20 30 40 50 pF1KE2 MLSAVARGYQGWFHPCARL--SVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLAR : . ::: ::::.:.:. :. :::.::.::.::.:::::::::::. CCDS61 MHKAGLLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQ 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 DGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLV ::::::.:::::::::.:.: ::::::::.: :::::::::::.::: CCDS61 DGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVATLWMDKEKEESMK 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 CSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRGAVILVSSIAAYNP CCDS61 ETLRIRRLGEPEDCAGIVSFLCSEDASYITGETVVVGGGTPSRL 120 130 140 150 >>CCDS33375.1 PECR gene_id:55825|Hs108|chr2 (303 aa) initn: 271 init1: 134 opt: 317 Z-score: 400.5 bits: 82.2 E(32554): 5.5e-16 Smith-Waterman score: 317; 31.0% identity (62.8% similar) in 258 aa overlap (32-275:14-259) 10 20 30 40 50 60 pF1KE2 LSAVARGYQGWFHPCARLSVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDGA :.: ..::.:::...::: ::...: . :. CCDS33 MASWAKGRSYLAPGLLQGQVAIVTGGATGIGKAIVKELLELGS 10 20 30 40 70 80 90 100 110 pF1KE2 HVVISSRKQQNVDRAMAKLQG-----EGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDF .:::.::: . . : .::. . : : :.. . :. ..:: ..:. : ..: CCDS33 NVVIASRKLERLKSAADELQANLPPTKQARVIPIQCNIRNEEEVNNLVKSTLDTFGKINF 50 60 70 80 90 100 120 130 140 150 160 pF1KE2 LVCSAGVNPLVGSTLGTSEQI----WDKILSVNVKSPALLLSQLLP-YMENRRGAV--IL :: ..: :. :. .:.: : .: .:. . . . . .:... :.. :. CCDS33 LVNNGG-----GQFLSPAEHISSKGWHAVLETNLTGTFYMCKAVYSSWMKEHGGSIVNII 110 120 130 140 150 170 180 190 200 210 220 pF1KE2 VSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNCVVPGIIKTDFSKVVRIG : . :.. .: : ...... .::..:::: : . ::.:::.::.: .. . : : CCDS33 VPTKAGFPLAVHSG---AARAGVYNLTKSLALEWACSGIRINCVAPGVIYSQ-TAVENYG 160 170 180 190 200 210 230 240 250 260 270 280 pF1KE2 FMGMSLSGRTSRNIISCRGLGSQRTVQESCPSCALQMPATS--TGRTLRWQATPLGSERS :.:. . ..: . : .: . : : : : ::.: ::... CCDS33 SWGQSFFEGSFQKIPAKR-IGVPEEV--SSVVCFLLSPAASFITGQSVDVDGGRSLYTHS 220 230 240 250 260 270 290 300 pF1KE2 GGGCVAVVPGPGA CCDS33 YEVPDHDNWPKGAGDLSVVKKMKETFKEKAKL 280 290 300 300 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Jun 6 17:56:33 2018 done: Wed Jun 6 17:56:33 2018 Total Scan time: 1.080 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]