Result of FASTA (omim) for
pFN21AE6734
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6734, 911 aa
1>>>pF1KE6734 911 - 911 aa - 911 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.8179+/-0.000404; mu= -7.3549+/- 0.025
mean_var=429.3240+/-88.261, 0's: 0 Z-trim(123.3): 14 B-trim: 0 in 0/59
Lambda= 0.061899
statistics sampled from 42782 (42804) to 42782 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.786), E-opt: 0.2 (0.502), width: 16
Scan time: 14.730
The best scores are: opt bits E(85289)
NP_001017995 (OMIM: 249420,613293) SH3 and PX doma ( 911) 6303 577.8 8.1e-164
XP_016864840 (OMIM: 249420,613293) PREDICTED: SH3 ( 939) 4804 444.0 1.6e-123
NP_001295104 (OMIM: 249420,613293) SH3 and PX doma ( 430) 2723 257.8 8.1e-68
NP_000256 (OMIM: 233700,608512) neutrophil cytosol ( 390) 722 79.1 4.7e-14
>>NP_001017995 (OMIM: 249420,613293) SH3 and PX domain-c (911 aa)
initn: 6303 init1: 6303 opt: 6303 Z-score: 3062.0 bits: 577.8 E(85289): 8.1e-164
Smith-Waterman score: 6303; 100.0% identity (100.0% similar) in 911 aa overlap (1-911:1-911)
10 20 30 40 50 60
pF1KE6 MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 MEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 FFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 IIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 NLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 DGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 PKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPAT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 FIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 GLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLERE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLERE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 RERQRTEQLRGPTPKPPGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDMGLECGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RERQRTEQLRGPTPKPPGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDMGLECGH
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE6 KVLAKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVLAKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQ
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE6 VDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE6 PKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE6 PQCEGHESRAAPTPGRALLVPPKAKPFLSNSLGGQDDTRGKGSLGPWGTGKIGENREKAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQCEGHESRAAPTPGRALLVPPKAKPFLSNSLGGQDDTRGKGSLGPWGTGKIGENREKAA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE6 AASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEG
850 860 870 880 890 900
910
pF1KE6 WIPSNYLRKKP
:::::::::::
NP_001 WIPSNYLRKKP
910
>>XP_016864840 (OMIM: 249420,613293) PREDICTED: SH3 and (939 aa)
initn: 4804 init1: 4804 opt: 4804 Z-score: 2338.4 bits: 444.0 E(85289): 1.6e-123
Smith-Waterman score: 6237; 97.0% identity (97.0% similar) in 939 aa overlap (1-911:1-939)
10 20 30 40 50 60
pF1KE6 MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 MEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 FFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVD
130 140 150 160 170 180
190 200 210 220
pF1KE6 IIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEE------------------
::::::::::::::::::::::::::::::::::::::::::
XP_016 IIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEVSWRYWSLPRPVGRRRTL
190 200 210 220 230 240
230 240 250 260 270
pF1KE6 ----------EEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPA
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDLYAISWRQEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPA
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE6 SYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPD
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE6 GDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAG
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE6 LKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEA
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE6 AALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKDVLRKASSDMSASAGYEEIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKDVLRKASSDMSASAGYEEIS
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE6 DPDMEEKPSLPPRKESIIKSEGELLERERERQRTEQLRGPTPKPPGVILPMMPAKHIPPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPDMEEKPSLPPRKESIIKSEGELLERERERQRTEQLRGPTPKPPGVILPMMPAKHIPPA
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE6 RDSRRPEPKPDKSRLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDLPEEKPDATPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDSRRPEPKPDKSRLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDLPEEKPDATPQ
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE6 NPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQ
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE6 DVAFSRSFLPGEGPGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVAFSRSFLPGEGPGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQ
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE6 QRPVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKPFLSNSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRPVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKPFLSNSL
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE6 GGQDDTRGKGSLGPWGTGKIGENREKAAAASVPNADGLKDSLYVAVADFEGDKDTSSFQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGQDDTRGKGSLGPWGTGKIGENREKAAAASVPNADGLKDSLYVAVADFEGDKDTSSFQE
850 860 870 880 890 900
880 890 900 910
pF1KE6 GTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP
:::::::::::::::::::::::::::::::::::::::
XP_016 GTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP
910 920 930
>>NP_001295104 (OMIM: 249420,613293) SH3 and PX domain-c (430 aa)
initn: 2723 init1: 2723 opt: 2723 Z-score: 1338.5 bits: 257.8 E(85289): 8.1e-68
Smith-Waterman score: 2723; 100.0% identity (100.0% similar) in 396 aa overlap (1-396:1-396)
10 20 30 40 50 60
pF1KE6 MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 MEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 FFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 IIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 NLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 DGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 PKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPAT
::::::::::::::::::::::::::::::::::::
NP_001 PKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEDHKNVHLESPVEVPLRRIKMRTAL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 FIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDS
NP_001 GKHVAASMEM
430
>>NP_000256 (OMIM: 233700,608512) neutrophil cytosol fac (390 aa)
initn: 694 init1: 237 opt: 722 Z-score: 373.3 bits: 79.1 E(85289): 4.7e-14
Smith-Waterman score: 738; 34.9% identity (64.8% similar) in 381 aa overlap (7-368:6-368)
10 20 30 40 50 60
pF1KE6 MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFP
: .. .: .:: ::..::::.. : :.. : ...:::........ . . ::
NP_000 MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFP
10 20 30 40 50
70 80 90 100 110 120
pF1KE6 MEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQ
.:.: .:..:::: ::. : .. .: .: . :::..:..:: ::.: ..:.
NP_000 IEAGAINPENRIIPHLPAPKWFDGQR---AAENRQGTLTEYCSTLMSLPTKISRCPHLLD
60 70 80 90 100 110
130 140 150 160 170
pF1KE6 FFETRPEDLNPPKEEHIGKKKS-----GGDQTSVD---PMVLEQYVVVANYQKQESSEIS
::..::.::. : ... : .. : .:..: :..:. : ..:::.: .::..
NP_000 FFKVRPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMA
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE6 LSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEE-EKYTVIYP
::.:.::...::.:::::: . ..::.::. :: :. .. . .:. : :..:
NP_000 LSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKA
180 190 200 210 220 230
240 250 260 270 280
pF1KE6 YTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPP-----K
::: . ::..: .: .::::.: :.::: :: . :. :. ::.: ::. . :
NP_000 YTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQK-SGQDVSQAQRQIK
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE6 PG--PGSPSHPGALDLDGVSRQ---QNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPK
: : : .: .. ::. :.: :.. . .:: : ..:: :.. . ::
NP_000 RGAPPRRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQR--RRQARPGPQSPG---SPL
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE6 MRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKN
..: : :.: .::.
NP_000 EEERQTQRSK---------PQPAVPPRPSADLILNRCSESTKRKLASAV
360 370 380 390
911 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 15:50:44 2016 done: Tue Nov 8 15:50:46 2016
Total Scan time: 14.730 Total Display time: 0.090
Function used was FASTA [36.3.4 Apr, 2011]