FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6293, 806 aa 1>>>pF1KB6293 806 - 806 aa - 806 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.8019+/-0.000424; mu= 15.2161+/- 0.026 mean_var=167.5242+/-34.534, 0's: 0 Z-trim(117.0): 293 B-trim: 315 in 1/53 Lambda= 0.099091 statistics sampled from 28221 (28569) to 28221 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.687), E-opt: 0.2 (0.335), width: 16 Scan time: 11.210 The best scores are: opt bits E(85289) NP_037414 (OMIM: 607990) E3 ubiquitin-protein liga ( 806) 5583 811.2 0 NP_001276981 (OMIM: 607990) E3 ubiquitin-protein l ( 793) 5501 799.4 0 NP_001041666 (OMIM: 607990) E3 ubiquitin-protein l ( 793) 5501 799.4 0 NP_001276980 (OMIM: 607990) E3 ubiquitin-protein l ( 793) 5501 799.4 0 NP_001276979 (OMIM: 607990) E3 ubiquitin-protein l ( 793) 5501 799.4 0 XP_011526244 (OMIM: 607990) PREDICTED: E3 ubiquiti ( 758) 3030 446.2 2.5e-124 NP_690856 (OMIM: 615211) E3 ubiquitin-protein liga ( 802) 2118 315.8 4.7e-85 XP_011516007 (OMIM: 615211) PREDICTED: E3 ubiquiti ( 579) 2007 299.8 2.2e-80 XP_011516006 (OMIM: 615211) PREDICTED: E3 ubiquiti ( 579) 2007 299.8 2.2e-80 XP_016869743 (OMIM: 615211) PREDICTED: E3 ubiquiti ( 522) 1773 266.3 2.5e-70 XP_016869742 (OMIM: 615211) PREDICTED: E3 ubiquiti ( 729) 1771 266.2 3.8e-70 XP_011518539 (OMIM: 611780) PREDICTED: PHD and RIN (1609) 235 47.0 0.00081 NP_001273512 (OMIM: 611780) PHD and RING finger do (1645) 235 47.0 0.00082 XP_005253084 (OMIM: 611780) PREDICTED: PHD and RIN (1646) 235 47.0 0.00082 NP_001273511 (OMIM: 611780) PHD and RING finger do (1647) 235 47.0 0.00082 XP_011518538 (OMIM: 611780) PREDICTED: PHD and RIN (1647) 235 47.0 0.00082 NP_065952 (OMIM: 611780) PHD and RING finger domai (1648) 235 47.0 0.00082 XP_005253082 (OMIM: 611780) PREDICTED: PHD and RIN (1648) 235 47.0 0.00082 NP_001273510 (OMIM: 611780) PHD and RING finger do (1649) 235 47.0 0.00082 NP_001128628 (OMIM: 601670) zinc finger protein ne ( 332) 201 41.4 0.0081 XP_011537078 (OMIM: 147920,602113) PREDICTED: hist (5525) 220 45.4 0.0082 XP_006719679 (OMIM: 147920,602113) PREDICTED: hist (5536) 220 45.4 0.0082 NP_003473 (OMIM: 147920,602113) histone-lysine N-m (5537) 220 45.4 0.0082 XP_005269219 (OMIM: 147920,602113) PREDICTED: hist (5537) 220 45.4 0.0082 XP_006719677 (OMIM: 147920,602113) PREDICTED: hist (5540) 220 45.4 0.0082 XP_011537076 (OMIM: 147920,602113) PREDICTED: hist (5549) 220 45.4 0.0082 XP_011537075 (OMIM: 147920,602113) PREDICTED: hist (5552) 220 45.4 0.0082 XP_011537074 (OMIM: 147920,602113) PREDICTED: hist (5553) 220 45.4 0.0082 XP_011537073 (OMIM: 147920,602113) PREDICTED: hist (5555) 220 45.4 0.0082 XP_011537072 (OMIM: 147920,602113) PREDICTED: hist (5556) 220 45.4 0.0082 XP_005259349 (OMIM: 601670) PREDICTED: zinc finger ( 369) 201 41.4 0.0087 XP_005259347 (OMIM: 601670) PREDICTED: zinc finger ( 388) 201 41.4 0.009 XP_005259346 (OMIM: 601670) PREDICTED: zinc finger ( 397) 201 41.4 0.0092 NP_001128627 (OMIM: 601670) zinc finger protein ne ( 414) 201 41.5 0.0094 XP_011514756 (OMIM: 606833) PREDICTED: histone-lys (4678) 217 44.9 0.0099 >>NP_037414 (OMIM: 607990) E3 ubiquitin-protein ligase U (806 aa) initn: 5583 init1: 5583 opt: 5583 Z-score: 4325.1 bits: 811.2 E(85289): 0 Smith-Waterman score: 5583; 99.9% identity (100.0% similar) in 806 aa overlap (1-806:1-806) 10 20 30 40 50 60 pF1KB6 MGVFAVPPLSSDTMWIQVRTMDGRQTHTVDSLSRLTKVEELRRKIQELFHVEPGLQRLFY ::::::::::.::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 MGVFAVPPLSADTMWIQVRTMDGRQTHTVDSLSRLTKVEELRRKIQELFHVEPGLQRLFY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 RGKQMEDGHTLFDYEVRLNDTIQLLVRQSLVLPHSTKERDSELSDTDSGCCLGQSESDKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 RGKQMEDGHTLFDYEVRLNDTIQLLVRQSLVLPHSTKERDSELSDTDSGCCLGQSESDKS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 STHGEAAAETDSRPADEDMWDETELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 STHGEAAAETDSRPADEDMWDETELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 EPCSSTSRPALEEDVIYHVKYDDYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 EPCSSTSRPALEEDVIYHVKYDDYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 NPDNPKERGFWYDAEISRKRETRTARELYANVVLGDDSLNDCRIIFVDEVFKIERPGEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 NPDNPKERGFWYDAEISRKRETRTARELYANVVLGDDSLNDCRIIFVDEVFKIERPGEGS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 PMVDNPMRRKSGPSCKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIYCLDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 PMVDNPMRRKSGPSCKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIYCLDP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 PLSSVPSEDEWYCPECRNDASEVVLAGERLRESKKKAKMASATSSSQRDWGKGMACVGRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 PLSSVPSEDEWYCPECRNDASEVVLAGERLRESKKKAKMASATSSSQRDWGKGMACVGRT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 KECTIVPSNHYGPIPGIPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 KECTIVPSNHYGPIPGIPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 DDVDHGNFFTYTGSGGRDLSGNKRTAEQSCDQKLTNTNRALALNCFAPINDQEGAEAKDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 DDVDHGNFFTYTGSGGRDLSGNKRTAEQSCDQKLTNTNRALALNCFAPINDQEGAEAKDW 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB6 RSGKPVRVVRNVKGGKNSKYAPAEGNRYDGIYKVVKYWPEKGKSGFLVWRYLLRRDDDEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 RSGKPVRVVRNVKGGKNSKYAPAEGNRYDGIYKVVKYWPEKGKSGFLVWRYLLRRDDDEP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB6 GPWTKEGKDRIKKLGLTMQYPEGYLEALANREREKENSKREEEEQQEGGFASPRTGKGKW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 GPWTKEGKDRIKKLGLTMQYPEGYLEALANREREKENSKREEEEQQEGGFASPRTGKGKW 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB6 KRKSAGGGPSRAGSPRRTSKKTKVEPYSLTAQQSSLIREDKSNAKLWNEVLASLKDRPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 KRKSAGGGPSRAGSPRRTSKKTKVEPYSLTAQQSSLIREDKSNAKLWNEVLASLKDRPAS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB6 GSPFQLFLSKVEETFQCICCQELVFRPITTVCQHNVCKDCLDRSFRAQVFSCPACRYDLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 GSPFQLFLSKVEETFQCICCQELVFRPITTVCQHNVCKDCLDRSFRAQVFSCPACRYDLG 730 740 750 760 770 780 790 800 pF1KB6 RSYAMQVNQPLQTVLNQLFPGYGNGR :::::::::::::::::::::::::: NP_037 RSYAMQVNQPLQTVLNQLFPGYGNGR 790 800 >>NP_001276981 (OMIM: 607990) E3 ubiquitin-protein ligas (793 aa) initn: 5501 init1: 5501 opt: 5501 Z-score: 4261.8 bits: 799.4 E(85289): 0 Smith-Waterman score: 5501; 100.0% identity (100.0% similar) in 793 aa overlap (14-806:1-793) 10 20 30 40 50 60 pF1KB6 MGVFAVPPLSSDTMWIQVRTMDGRQTHTVDSLSRLTKVEELRRKIQELFHVEPGLQRLFY ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MWIQVRTMDGRQTHTVDSLSRLTKVEELRRKIQELFHVEPGLQRLFY 10 20 30 40 70 80 90 100 110 120 pF1KB6 RGKQMEDGHTLFDYEVRLNDTIQLLVRQSLVLPHSTKERDSELSDTDSGCCLGQSESDKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGKQMEDGHTLFDYEVRLNDTIQLLVRQSLVLPHSTKERDSELSDTDSGCCLGQSESDKS 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB6 STHGEAAAETDSRPADEDMWDETELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STHGEAAAETDSRPADEDMWDETELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRD 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB6 EPCSSTSRPALEEDVIYHVKYDDYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPCSSTSRPALEEDVIYHVKYDDYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNY 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB6 NPDNPKERGFWYDAEISRKRETRTARELYANVVLGDDSLNDCRIIFVDEVFKIERPGEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NPDNPKERGFWYDAEISRKRETRTARELYANVVLGDDSLNDCRIIFVDEVFKIERPGEGS 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB6 PMVDNPMRRKSGPSCKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIYCLDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PMVDNPMRRKSGPSCKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIYCLDP 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB6 PLSSVPSEDEWYCPECRNDASEVVLAGERLRESKKKAKMASATSSSQRDWGKGMACVGRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLSSVPSEDEWYCPECRNDASEVVLAGERLRESKKKAKMASATSSSQRDWGKGMACVGRT 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB6 KECTIVPSNHYGPIPGIPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KECTIVPSNHYGPIPGIPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYE 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB6 DDVDHGNFFTYTGSGGRDLSGNKRTAEQSCDQKLTNTNRALALNCFAPINDQEGAEAKDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDVDHGNFFTYTGSGGRDLSGNKRTAEQSCDQKLTNTNRALALNCFAPINDQEGAEAKDW 470 480 490 500 510 520 550 560 570 580 590 600 pF1KB6 RSGKPVRVVRNVKGGKNSKYAPAEGNRYDGIYKVVKYWPEKGKSGFLVWRYLLRRDDDEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSGKPVRVVRNVKGGKNSKYAPAEGNRYDGIYKVVKYWPEKGKSGFLVWRYLLRRDDDEP 530 540 550 560 570 580 610 620 630 640 650 660 pF1KB6 GPWTKEGKDRIKKLGLTMQYPEGYLEALANREREKENSKREEEEQQEGGFASPRTGKGKW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPWTKEGKDRIKKLGLTMQYPEGYLEALANREREKENSKREEEEQQEGGFASPRTGKGKW 590 600 610 620 630 640 670 680 690 700 710 720 pF1KB6 KRKSAGGGPSRAGSPRRTSKKTKVEPYSLTAQQSSLIREDKSNAKLWNEVLASLKDRPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRKSAGGGPSRAGSPRRTSKKTKVEPYSLTAQQSSLIREDKSNAKLWNEVLASLKDRPAS 650 660 670 680 690 700 730 740 750 760 770 780 pF1KB6 GSPFQLFLSKVEETFQCICCQELVFRPITTVCQHNVCKDCLDRSFRAQVFSCPACRYDLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSPFQLFLSKVEETFQCICCQELVFRPITTVCQHNVCKDCLDRSFRAQVFSCPACRYDLG 710 720 730 740 750 760 790 800 pF1KB6 RSYAMQVNQPLQTVLNQLFPGYGNGR :::::::::::::::::::::::::: NP_001 RSYAMQVNQPLQTVLNQLFPGYGNGR 770 780 790 >>NP_001041666 (OMIM: 607990) E3 ubiquitin-protein ligas (793 aa) initn: 5501 init1: 5501 opt: 5501 Z-score: 4261.8 bits: 799.4 E(85289): 0 Smith-Waterman score: 5501; 100.0% identity (100.0% similar) in 793 aa overlap (14-806:1-793) 10 20 30 40 50 60 pF1KB6 MGVFAVPPLSSDTMWIQVRTMDGRQTHTVDSLSRLTKVEELRRKIQELFHVEPGLQRLFY ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MWIQVRTMDGRQTHTVDSLSRLTKVEELRRKIQELFHVEPGLQRLFY 10 20 30 40 70 80 90 100 110 120 pF1KB6 RGKQMEDGHTLFDYEVRLNDTIQLLVRQSLVLPHSTKERDSELSDTDSGCCLGQSESDKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGKQMEDGHTLFDYEVRLNDTIQLLVRQSLVLPHSTKERDSELSDTDSGCCLGQSESDKS 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB6 STHGEAAAETDSRPADEDMWDETELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STHGEAAAETDSRPADEDMWDETELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRD 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB6 EPCSSTSRPALEEDVIYHVKYDDYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPCSSTSRPALEEDVIYHVKYDDYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNY 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB6 NPDNPKERGFWYDAEISRKRETRTARELYANVVLGDDSLNDCRIIFVDEVFKIERPGEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NPDNPKERGFWYDAEISRKRETRTARELYANVVLGDDSLNDCRIIFVDEVFKIERPGEGS 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB6 PMVDNPMRRKSGPSCKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIYCLDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PMVDNPMRRKSGPSCKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIYCLDP 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB6 PLSSVPSEDEWYCPECRNDASEVVLAGERLRESKKKAKMASATSSSQRDWGKGMACVGRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLSSVPSEDEWYCPECRNDASEVVLAGERLRESKKKAKMASATSSSQRDWGKGMACVGRT 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB6 KECTIVPSNHYGPIPGIPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KECTIVPSNHYGPIPGIPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYE 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB6 DDVDHGNFFTYTGSGGRDLSGNKRTAEQSCDQKLTNTNRALALNCFAPINDQEGAEAKDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDVDHGNFFTYTGSGGRDLSGNKRTAEQSCDQKLTNTNRALALNCFAPINDQEGAEAKDW 470 480 490 500 510 520 550 560 570 580 590 600 pF1KB6 RSGKPVRVVRNVKGGKNSKYAPAEGNRYDGIYKVVKYWPEKGKSGFLVWRYLLRRDDDEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSGKPVRVVRNVKGGKNSKYAPAEGNRYDGIYKVVKYWPEKGKSGFLVWRYLLRRDDDEP 530 540 550 560 570 580 610 620 630 640 650 660 pF1KB6 GPWTKEGKDRIKKLGLTMQYPEGYLEALANREREKENSKREEEEQQEGGFASPRTGKGKW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPWTKEGKDRIKKLGLTMQYPEGYLEALANREREKENSKREEEEQQEGGFASPRTGKGKW 590 600 610 620 630 640 670 680 690 700 710 720 pF1KB6 KRKSAGGGPSRAGSPRRTSKKTKVEPYSLTAQQSSLIREDKSNAKLWNEVLASLKDRPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRKSAGGGPSRAGSPRRTSKKTKVEPYSLTAQQSSLIREDKSNAKLWNEVLASLKDRPAS 650 660 670 680 690 700 730 740 750 760 770 780 pF1KB6 GSPFQLFLSKVEETFQCICCQELVFRPITTVCQHNVCKDCLDRSFRAQVFSCPACRYDLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSPFQLFLSKVEETFQCICCQELVFRPITTVCQHNVCKDCLDRSFRAQVFSCPACRYDLG 710 720 730 740 750 760 790 800 pF1KB6 RSYAMQVNQPLQTVLNQLFPGYGNGR :::::::::::::::::::::::::: NP_001 RSYAMQVNQPLQTVLNQLFPGYGNGR 770 780 790 >>NP_001276980 (OMIM: 607990) E3 ubiquitin-protein ligas (793 aa) initn: 5501 init1: 5501 opt: 5501 Z-score: 4261.8 bits: 799.4 E(85289): 0 Smith-Waterman score: 5501; 100.0% identity (100.0% similar) in 793 aa overlap (14-806:1-793) 10 20 30 40 50 60 pF1KB6 MGVFAVPPLSSDTMWIQVRTMDGRQTHTVDSLSRLTKVEELRRKIQELFHVEPGLQRLFY ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MWIQVRTMDGRQTHTVDSLSRLTKVEELRRKIQELFHVEPGLQRLFY 10 20 30 40 70 80 90 100 110 120 pF1KB6 RGKQMEDGHTLFDYEVRLNDTIQLLVRQSLVLPHSTKERDSELSDTDSGCCLGQSESDKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGKQMEDGHTLFDYEVRLNDTIQLLVRQSLVLPHSTKERDSELSDTDSGCCLGQSESDKS 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB6 STHGEAAAETDSRPADEDMWDETELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STHGEAAAETDSRPADEDMWDETELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRD 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB6 EPCSSTSRPALEEDVIYHVKYDDYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPCSSTSRPALEEDVIYHVKYDDYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNY 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB6 NPDNPKERGFWYDAEISRKRETRTARELYANVVLGDDSLNDCRIIFVDEVFKIERPGEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NPDNPKERGFWYDAEISRKRETRTARELYANVVLGDDSLNDCRIIFVDEVFKIERPGEGS 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB6 PMVDNPMRRKSGPSCKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIYCLDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PMVDNPMRRKSGPSCKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIYCLDP 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB6 PLSSVPSEDEWYCPECRNDASEVVLAGERLRESKKKAKMASATSSSQRDWGKGMACVGRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLSSVPSEDEWYCPECRNDASEVVLAGERLRESKKKAKMASATSSSQRDWGKGMACVGRT 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB6 KECTIVPSNHYGPIPGIPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KECTIVPSNHYGPIPGIPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYE 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB6 DDVDHGNFFTYTGSGGRDLSGNKRTAEQSCDQKLTNTNRALALNCFAPINDQEGAEAKDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDVDHGNFFTYTGSGGRDLSGNKRTAEQSCDQKLTNTNRALALNCFAPINDQEGAEAKDW 470 480 490 500 510 520 550 560 570 580 590 600 pF1KB6 RSGKPVRVVRNVKGGKNSKYAPAEGNRYDGIYKVVKYWPEKGKSGFLVWRYLLRRDDDEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSGKPVRVVRNVKGGKNSKYAPAEGNRYDGIYKVVKYWPEKGKSGFLVWRYLLRRDDDEP 530 540 550 560 570 580 610 620 630 640 650 660 pF1KB6 GPWTKEGKDRIKKLGLTMQYPEGYLEALANREREKENSKREEEEQQEGGFASPRTGKGKW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPWTKEGKDRIKKLGLTMQYPEGYLEALANREREKENSKREEEEQQEGGFASPRTGKGKW 590 600 610 620 630 640 670 680 690 700 710 720 pF1KB6 KRKSAGGGPSRAGSPRRTSKKTKVEPYSLTAQQSSLIREDKSNAKLWNEVLASLKDRPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRKSAGGGPSRAGSPRRTSKKTKVEPYSLTAQQSSLIREDKSNAKLWNEVLASLKDRPAS 650 660 670 680 690 700 730 740 750 760 770 780 pF1KB6 GSPFQLFLSKVEETFQCICCQELVFRPITTVCQHNVCKDCLDRSFRAQVFSCPACRYDLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSPFQLFLSKVEETFQCICCQELVFRPITTVCQHNVCKDCLDRSFRAQVFSCPACRYDLG 710 720 730 740 750 760 790 800 pF1KB6 RSYAMQVNQPLQTVLNQLFPGYGNGR :::::::::::::::::::::::::: NP_001 RSYAMQVNQPLQTVLNQLFPGYGNGR 770 780 790 >>NP_001276979 (OMIM: 607990) E3 ubiquitin-protein ligas (793 aa) initn: 5501 init1: 5501 opt: 5501 Z-score: 4261.8 bits: 799.4 E(85289): 0 Smith-Waterman score: 5501; 100.0% identity (100.0% similar) in 793 aa overlap (14-806:1-793) 10 20 30 40 50 60 pF1KB6 MGVFAVPPLSSDTMWIQVRTMDGRQTHTVDSLSRLTKVEELRRKIQELFHVEPGLQRLFY ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MWIQVRTMDGRQTHTVDSLSRLTKVEELRRKIQELFHVEPGLQRLFY 10 20 30 40 70 80 90 100 110 120 pF1KB6 RGKQMEDGHTLFDYEVRLNDTIQLLVRQSLVLPHSTKERDSELSDTDSGCCLGQSESDKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGKQMEDGHTLFDYEVRLNDTIQLLVRQSLVLPHSTKERDSELSDTDSGCCLGQSESDKS 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB6 STHGEAAAETDSRPADEDMWDETELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STHGEAAAETDSRPADEDMWDETELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRD 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB6 EPCSSTSRPALEEDVIYHVKYDDYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPCSSTSRPALEEDVIYHVKYDDYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNY 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB6 NPDNPKERGFWYDAEISRKRETRTARELYANVVLGDDSLNDCRIIFVDEVFKIERPGEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NPDNPKERGFWYDAEISRKRETRTARELYANVVLGDDSLNDCRIIFVDEVFKIERPGEGS 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB6 PMVDNPMRRKSGPSCKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIYCLDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PMVDNPMRRKSGPSCKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIYCLDP 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB6 PLSSVPSEDEWYCPECRNDASEVVLAGERLRESKKKAKMASATSSSQRDWGKGMACVGRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLSSVPSEDEWYCPECRNDASEVVLAGERLRESKKKAKMASATSSSQRDWGKGMACVGRT 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB6 KECTIVPSNHYGPIPGIPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KECTIVPSNHYGPIPGIPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYE 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB6 DDVDHGNFFTYTGSGGRDLSGNKRTAEQSCDQKLTNTNRALALNCFAPINDQEGAEAKDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDVDHGNFFTYTGSGGRDLSGNKRTAEQSCDQKLTNTNRALALNCFAPINDQEGAEAKDW 470 480 490 500 510 520 550 560 570 580 590 600 pF1KB6 RSGKPVRVVRNVKGGKNSKYAPAEGNRYDGIYKVVKYWPEKGKSGFLVWRYLLRRDDDEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSGKPVRVVRNVKGGKNSKYAPAEGNRYDGIYKVVKYWPEKGKSGFLVWRYLLRRDDDEP 530 540 550 560 570 580 610 620 630 640 650 660 pF1KB6 GPWTKEGKDRIKKLGLTMQYPEGYLEALANREREKENSKREEEEQQEGGFASPRTGKGKW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPWTKEGKDRIKKLGLTMQYPEGYLEALANREREKENSKREEEEQQEGGFASPRTGKGKW 590 600 610 620 630 640 670 680 690 700 710 720 pF1KB6 KRKSAGGGPSRAGSPRRTSKKTKVEPYSLTAQQSSLIREDKSNAKLWNEVLASLKDRPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRKSAGGGPSRAGSPRRTSKKTKVEPYSLTAQQSSLIREDKSNAKLWNEVLASLKDRPAS 650 660 670 680 690 700 730 740 750 760 770 780 pF1KB6 GSPFQLFLSKVEETFQCICCQELVFRPITTVCQHNVCKDCLDRSFRAQVFSCPACRYDLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSPFQLFLSKVEETFQCICCQELVFRPITTVCQHNVCKDCLDRSFRAQVFSCPACRYDLG 710 720 730 740 750 760 790 800 pF1KB6 RSYAMQVNQPLQTVLNQLFPGYGNGR :::::::::::::::::::::::::: NP_001 RSYAMQVNQPLQTVLNQLFPGYGNGR 770 780 790 >>XP_011526244 (OMIM: 607990) PREDICTED: E3 ubiquitin-pr (758 aa) initn: 5251 init1: 3030 opt: 3030 Z-score: 2352.9 bits: 446.2 E(85289): 2.5e-124 Smith-Waterman score: 5185; 95.6% identity (95.6% similar) in 793 aa overlap (14-806:1-758) 10 20 30 40 50 60 pF1KB6 MGVFAVPPLSSDTMWIQVRTMDGRQTHTVDSLSRLTKVEELRRKIQELFHVEPGLQRLFY ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MWIQVRTMDGRQTHTVDSLSRLTKVEELRRKIQELFHVEPGLQRLFY 10 20 30 40 70 80 90 100 110 120 pF1KB6 RGKQMEDGHTLFDYEVRLNDTIQLLVRQSLVLPHSTKERDSELSDTDSGCCLGQSESDKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGKQMEDGHTLFDYEVRLNDTIQLLVRQSLVLPHSTKERDSELSDTDSGCCLGQSESDKS 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB6 STHGEAAAETDSRPADEDMWDETELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 STHGEAAAETDSRPADEDMWDETELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRD 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB6 EPCSSTSRPALEEDVIYHVKYDDYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EPCSSTSRPALEEDVIYHVKYDDYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNY 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB6 NPDNPKERGFWYDAEISRKRETRTARELYANVVLGDDSLNDCRIIFVDEVFKIERPGEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NPDNPKERGFWYDAEISRKRETRTARELYANVVLGDDSLNDCRIIFVDEVFKIERPGEGS 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB6 PMVDNPMRRKSGPSCKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIYCLDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PMVDNPMRRKSGPSCKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIYCLDP 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB6 PLSSVPSEDEWYCPECRNDASEVVLAGERLRESKKKAKMASATSSSQRDWGKGMACVGRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLSSVPSEDEWYCPECRNDASEVVLAGERLRESKKKAKMASATSSSQRDWGKGMACVGRT 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB6 KECTIVPSNHYGPIPGIPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYE :::::::::::::::::::::::::::: XP_011 KECTIVPSNHYGPIPGIPVGTMWRFRVQ-------------------------------- 410 420 430 490 500 510 520 530 540 pF1KB6 DDVDHGNFFTYTGSGGRDLSGNKRTAEQSCDQKLTNTNRALALNCFAPINDQEGAEAKDW ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ---DHGNFFTYTGSGGRDLSGNKRTAEQSCDQKLTNTNRALALNCFAPINDQEGAEAKDW 440 450 460 470 480 490 550 560 570 580 590 600 pF1KB6 RSGKPVRVVRNVKGGKNSKYAPAEGNRYDGIYKVVKYWPEKGKSGFLVWRYLLRRDDDEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSGKPVRVVRNVKGGKNSKYAPAEGNRYDGIYKVVKYWPEKGKSGFLVWRYLLRRDDDEP 500 510 520 530 540 550 610 620 630 640 650 660 pF1KB6 GPWTKEGKDRIKKLGLTMQYPEGYLEALANREREKENSKREEEEQQEGGFASPRTGKGKW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPWTKEGKDRIKKLGLTMQYPEGYLEALANREREKENSKREEEEQQEGGFASPRTGKGKW 560 570 580 590 600 610 670 680 690 700 710 720 pF1KB6 KRKSAGGGPSRAGSPRRTSKKTKVEPYSLTAQQSSLIREDKSNAKLWNEVLASLKDRPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRKSAGGGPSRAGSPRRTSKKTKVEPYSLTAQQSSLIREDKSNAKLWNEVLASLKDRPAS 620 630 640 650 660 670 730 740 750 760 770 780 pF1KB6 GSPFQLFLSKVEETFQCICCQELVFRPITTVCQHNVCKDCLDRSFRAQVFSCPACRYDLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSPFQLFLSKVEETFQCICCQELVFRPITTVCQHNVCKDCLDRSFRAQVFSCPACRYDLG 680 690 700 710 720 730 790 800 pF1KB6 RSYAMQVNQPLQTVLNQLFPGYGNGR :::::::::::::::::::::::::: XP_011 RSYAMQVNQPLQTVLNQLFPGYGNGR 740 750 >>NP_690856 (OMIM: 615211) E3 ubiquitin-protein ligase U (802 aa) initn: 2841 init1: 1470 opt: 2118 Z-score: 1648.0 bits: 315.8 E(85289): 4.7e-85 Smith-Waterman score: 2977; 53.8% identity (74.4% similar) in 833 aa overlap (14-806:1-802) 10 20 30 40 50 60 pF1KB6 MGVFAVPPLSSDTMWIQVRTMDGRQTHTVDSLSRLTKVEELRRKIQELFHVEPGLQRLFY :::::::.:: .: :....:: . .::::... :: :.: ::::: NP_690 MWIQVRTIDGSKTCTIEDVSRKATIEELRERVWALFDVRPECQRLFY 10 20 30 40 70 80 90 100 110 pF1KB6 RGKQMEDGHTLFDYEVRLNDTIQLLVRQSLV-LPHSTKERDSELSDTDSGCCLGQSESDK ::::.:.:.:::::.: ::: :::::: . :: .. . ... : . . : NP_690 RGKQLENGYTLFDYDVGLNDIIQLLVRPDPDHLPGTSTQIEAK------PCSNSPPKVKK 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB6 SSTHGEAAAETDSRPADEDMWDETELGLYKVNEYVDARDTNMGAWFEAQVVRVTR----- . : . . : : . : .:.::::: :::::...::::::.. ::: NP_690 APRVGPSNQPSTS--ARARLIDPG-FGIYKVNELVDARDVGLGAWFEAHIHSVTRASDGQ 110 120 130 140 150 180 190 200 pF1KB6 ---KAPSRD-EPCSST----------------SRP--------ALEEDVIYHVKYDDYPE :.: .. :. : : : : .::::::..::.::: NP_690 SRGKTPLKNGSSCKRTNGNIKHKSKENTNKLDSVPSTSNSDCVAADEDVIYHIQYDEYPE 160 170 180 190 200 210 210 220 230 240 250 260 pF1KB6 NGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNYNPDNPKERGFWYDAEISR-KRETRTA .:...:: .:.: :::::.::..:.::.:::.::: ..: .::::.::::. : .:: NP_690 SGTLEMNVKDLRPRARTILKWNELNVGDVVMVNYNVESPGQRGFWFDAEITTLKTISRTK 220 230 240 250 260 270 270 280 290 300 310 320 pF1KB6 RELYANVVLG--DDSLNDCRIIFVDEVFKIERPGEGSPM--VDNPMRRKSGPSCKHCKDD .:: ... :: . .::::.:: :::.::::::: . :. .:. . :.. : : : : NP_690 KELRVKIFLGGSEGTLNDCKIISVDEIFKIERPG-AHPLSFADGKFLRRNDPECDLCGGD 280 290 300 310 320 330 330 340 350 360 370 380 pF1KB6 VNRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIYCLDPPLSSVPSEDEWYCPECRNDAS .. :. :.:..:::...:. ::.::::..:.:::::.:::..:: :. :::: :..:.: NP_690 PEKKCHSCSCRVCGGKHEPNMQLLCDECNVAYHIYCLNPPLDKVPEEEYWYCPSCKTDSS 340 350 360 370 380 390 390 400 410 420 430 440 pF1KB6 EVVLAGERLRESKKKAKMASATSSSQRDWGKGMACVGRTKECTIVPSNHYGPIPGIPVGT ::: :::::. ::::::: ::.. :.::::.::::::::.:::::::::::::::::::. NP_690 EVVKAGERLKMSKKKAKMPSASTESRRDWGRGMACVGRTRECTIVPSNHYGPIPGIPVGS 400 410 420 430 440 450 450 460 470 480 490 500 pF1KB6 MWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYEDDVDHGNFFTYTGSGGRDLSG :::::::::.:::::::.::::::::::::::::::. :.::.:. ::::::::..:.: NP_690 TWRFRVQVSEAGVHRPHVGGIHGRSNDGAYSLVLAGGFADEVDRGDEFTYTGSGGKNLAG 460 470 480 490 500 510 510 520 530 540 550 560 pF1KB6 NKRTAEQSCDQKLTNTNRALALNCFAPINDQEGAEAKDWRSGKPVRVVRNVKGGKNSKYA ::: . : :: ::: :::::::: ::..:. :::...::.::::::.:. :: : :::: NP_690 NKRIGAPSADQTLTNMNRALALNCDAPLDDKIGAESRNWRAGKPVRVIRSFKGRKISKYA 520 530 540 550 560 570 570 580 590 600 610 620 pF1KB6 PAEGNRYDGIYKVVKYWPEKGKS-GFLVWRYLLRRDDDEPGPWTKEGKDRIKKLGLTMQY : ::::::::::::::::: ..: ::::::::::::: ::.:::.:: .: ..: : .:: NP_690 PEEGNRYDGIYKVVKYWPEISSSHGFLVWRYLLRRDDVEPAPWTSEGIERSRRLCLRLQY 580 590 600 610 620 630 630 640 650 660 670 680 pF1KB6 PEGYLEALANREREKENSKREEEEQQEGGFASPRTGKGKWKRKSAGGGPSRAGSPRRTSK : :: ..: .. : . ..: : : : :: . . ... NP_690 PAGY-----PSDKEGKKPKGQSKKQPSGTTKRP---------ISDDDCPSASKVYKASDS 640 650 660 670 680 690 700 710 720 730 740 pF1KB6 KTKVEPYSLTAQQSSLIREDKSNAKLWNEVLASLKDRPASGSPFQLFLSKVEETFQCICC .: ..:: ::. ::::: .: :::.:::. : . : ::.:.:..:.:.:: NP_690 AEAIEAFQLTPQQQHLIREDCQNQKLWDEVLSHLVEGPN-------FLKKLEQSFMCVCC 690 700 710 720 730 750 760 770 780 790 800 pF1KB6 QELVFRPITTVCQHNVCKDCLDRSFRAQVFSCPACRYDLGRSYAMQVNQPLQTVLNQLFP ::::..:.:: : ::::::::.:::.::::::::::.:::..: : :. :::.:. .:: NP_690 QELVYQPVTTECFHNVCKDCLQRSFKAQVFSCPACRHDLGQNYIMIPNEILQTLLDLFFP 740 750 760 770 780 790 pF1KB6 GYGNGR ::..:: NP_690 GYSKGR 800 >>XP_011516007 (OMIM: 615211) PREDICTED: E3 ubiquitin-pr (579 aa) initn: 2303 init1: 1470 opt: 2007 Z-score: 1564.0 bits: 299.8 E(85289): 2.2e-80 Smith-Waterman score: 2499; 58.9% identity (79.5% similar) in 601 aa overlap (212-806:1-579) 190 200 210 220 230 240 pF1KB6 PCSSTSRPALEEDVIYHVKYDDYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNYN :: .:.: :::::.::..:.::.:::.::: XP_011 MNVKDLRPRARTILKWNELNVGDVVMVNYN 10 20 30 250 260 270 280 290 pF1KB6 PDNPKERGFWYDAEISR-KRETRTARELYANVVLG--DDSLNDCRIIFVDEVFKIERPGE ..: .::::.::::. : .:: .:: ... :: . .::::.:: :::.::::::: XP_011 VESPGQRGFWFDAEITTLKTISRTKKELRVKIFLGGSEGTLNDCKIISVDEIFKIERPG- 40 50 60 70 80 300 310 320 330 340 350 pF1KB6 GSPM--VDNPMRRKSGPSCKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIY . :. .:. . :.. : : : : .. :. :.:..:::...:. ::.::::..:.::: XP_011 AHPLSFADGKFLRRNDPECDLCGGDPEKKCHSCSCRVCGGKHEPNMQLLCDECNVAYHIY 90 100 110 120 130 140 360 370 380 390 400 410 pF1KB6 CLDPPLSSVPSEDEWYCPECRNDASEVVLAGERLRESKKKAKMASATSSSQRDWGKGMAC ::.:::..:: :. :::: :..:.:::: :::::. ::::::: ::.. :.::::.:::: XP_011 CLNPPLDKVPEEEYWYCPSCKTDSSEVVKAGERLKMSKKKAKMPSASTESRRDWGRGMAC 150 160 170 180 190 200 420 430 440 450 460 470 pF1KB6 VGRTKECTIVPSNHYGPIPGIPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLA ::::.:::::::::::::::::::. :::::::::.:::::::.:::::::::::::::: XP_011 VGRTRECTIVPSNHYGPIPGIPVGSTWRFRVQVSEAGVHRPHVGGIHGRSNDGAYSLVLA 210 220 230 240 250 260 480 490 500 510 520 530 pF1KB6 GGYEDDVDHGNFFTYTGSGGRDLSGNKRTAEQSCDQKLTNTNRALALNCFAPINDQEGAE ::. :.::.:. ::::::::..:.:::: . : :: ::: :::::::: ::..:. ::: XP_011 GGFADEVDRGDEFTYTGSGGKNLAGNKRIGAPSADQTLTNMNRALALNCDAPLDDKIGAE 270 280 290 300 310 320 540 550 560 570 580 590 pF1KB6 AKDWRSGKPVRVVRNVKGGKNSKYAPAEGNRYDGIYKVVKYWPEKGKS-GFLVWRYLLRR ...::.::::::.:. :: : ::::: ::::::::::::::::: ..: ::::::::::: XP_011 SRNWRAGKPVRVIRSFKGRKISKYAPEEGNRYDGIYKVVKYWPEISSSHGFLVWRYLLRR 330 340 350 360 370 380 600 610 620 630 640 650 pF1KB6 DDDEPGPWTKEGKDRIKKLGLTMQYPEGYLEALANREREKENSKREEEEQQEGGFASPRT :: ::.:::.:: .: ..: : .::: :: ..: .. : . ..: : : XP_011 DDVEPAPWTSEGIERSRRLCLRLQYPAGY-----PSDKEGKKPKGQSKKQPSGTTKRP-- 390 400 410 420 430 440 660 670 680 690 700 710 pF1KB6 GKGKWKRKSAGGGPSRAGSPRRTSKKTKVEPYSLTAQQSSLIREDKSNAKLWNEVLASLK : :: . . ... .: ..:: ::. ::::: .: :::.:::. : XP_011 -------ISDDDCPSASKVYKASDSAEAIEAFQLTPQQQHLIREDCQNQKLWDEVLSHLV 450 460 470 480 490 720 730 740 750 760 770 pF1KB6 DRPASGSPFQLFLSKVEETFQCICCQELVFRPITTVCQHNVCKDCLDRSFRAQVFSCPAC . : ::.:.:..:.:.::::::..:.:: : ::::::::.:::.::::::::: XP_011 EGPN-------FLKKLEQSFMCVCCQELVYQPVTTECFHNVCKDCLQRSFKAQVFSCPAC 500 510 520 530 540 780 790 800 pF1KB6 RYDLGRSYAMQVNQPLQTVLNQLFPGYGNGR :.:::..: : :. :::.:. .::::..:: XP_011 RHDLGQNYIMIPNEILQTLLDLFFPGYSKGR 550 560 570 >>XP_011516006 (OMIM: 615211) PREDICTED: E3 ubiquitin-pr (579 aa) initn: 2303 init1: 1470 opt: 2007 Z-score: 1564.0 bits: 299.8 E(85289): 2.2e-80 Smith-Waterman score: 2499; 58.9% identity (79.5% similar) in 601 aa overlap (212-806:1-579) 190 200 210 220 230 240 pF1KB6 PCSSTSRPALEEDVIYHVKYDDYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNYN :: .:.: :::::.::..:.::.:::.::: XP_011 MNVKDLRPRARTILKWNELNVGDVVMVNYN 10 20 30 250 260 270 280 290 pF1KB6 PDNPKERGFWYDAEISR-KRETRTARELYANVVLG--DDSLNDCRIIFVDEVFKIERPGE ..: .::::.::::. : .:: .:: ... :: . .::::.:: :::.::::::: XP_011 VESPGQRGFWFDAEITTLKTISRTKKELRVKIFLGGSEGTLNDCKIISVDEIFKIERPG- 40 50 60 70 80 300 310 320 330 340 350 pF1KB6 GSPM--VDNPMRRKSGPSCKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIY . :. .:. . :.. : : : : .. :. :.:..:::...:. ::.::::..:.::: XP_011 AHPLSFADGKFLRRNDPECDLCGGDPEKKCHSCSCRVCGGKHEPNMQLLCDECNVAYHIY 90 100 110 120 130 140 360 370 380 390 400 410 pF1KB6 CLDPPLSSVPSEDEWYCPECRNDASEVVLAGERLRESKKKAKMASATSSSQRDWGKGMAC ::.:::..:: :. :::: :..:.:::: :::::. ::::::: ::.. :.::::.:::: XP_011 CLNPPLDKVPEEEYWYCPSCKTDSSEVVKAGERLKMSKKKAKMPSASTESRRDWGRGMAC 150 160 170 180 190 200 420 430 440 450 460 470 pF1KB6 VGRTKECTIVPSNHYGPIPGIPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLA ::::.:::::::::::::::::::. :::::::::.:::::::.:::::::::::::::: XP_011 VGRTRECTIVPSNHYGPIPGIPVGSTWRFRVQVSEAGVHRPHVGGIHGRSNDGAYSLVLA 210 220 230 240 250 260 480 490 500 510 520 530 pF1KB6 GGYEDDVDHGNFFTYTGSGGRDLSGNKRTAEQSCDQKLTNTNRALALNCFAPINDQEGAE ::. :.::.:. ::::::::..:.:::: . : :: ::: :::::::: ::..:. ::: XP_011 GGFADEVDRGDEFTYTGSGGKNLAGNKRIGAPSADQTLTNMNRALALNCDAPLDDKIGAE 270 280 290 300 310 320 540 550 560 570 580 590 pF1KB6 AKDWRSGKPVRVVRNVKGGKNSKYAPAEGNRYDGIYKVVKYWPEKGKS-GFLVWRYLLRR ...::.::::::.:. :: : ::::: ::::::::::::::::: ..: ::::::::::: XP_011 SRNWRAGKPVRVIRSFKGRKISKYAPEEGNRYDGIYKVVKYWPEISSSHGFLVWRYLLRR 330 340 350 360 370 380 600 610 620 630 640 650 pF1KB6 DDDEPGPWTKEGKDRIKKLGLTMQYPEGYLEALANREREKENSKREEEEQQEGGFASPRT :: ::.:::.:: .: ..: : .::: :: ..: .. : . ..: : : XP_011 DDVEPAPWTSEGIERSRRLCLRLQYPAGY-----PSDKEGKKPKGQSKKQPSGTTKRP-- 390 400 410 420 430 440 660 670 680 690 700 710 pF1KB6 GKGKWKRKSAGGGPSRAGSPRRTSKKTKVEPYSLTAQQSSLIREDKSNAKLWNEVLASLK : :: . . ... .: ..:: ::. ::::: .: :::.:::. : XP_011 -------ISDDDCPSASKVYKASDSAEAIEAFQLTPQQQHLIREDCQNQKLWDEVLSHLV 450 460 470 480 490 720 730 740 750 760 770 pF1KB6 DRPASGSPFQLFLSKVEETFQCICCQELVFRPITTVCQHNVCKDCLDRSFRAQVFSCPAC . : ::.:.:..:.:.::::::..:.:: : ::::::::.:::.::::::::: XP_011 EGPN-------FLKKLEQSFMCVCCQELVYQPVTTECFHNVCKDCLQRSFKAQVFSCPAC 500 510 520 530 540 780 790 800 pF1KB6 RYDLGRSYAMQVNQPLQTVLNQLFPGYGNGR :.:::..: : :. :::.:. .::::..:: XP_011 RHDLGQNYIMIPNEILQTLLDLFFPGYSKGR 550 560 570 >>XP_016869743 (OMIM: 615211) PREDICTED: E3 ubiquitin-pr (522 aa) initn: 2097 init1: 1470 opt: 1773 Z-score: 1383.7 bits: 266.3 E(85289): 2.5e-70 Smith-Waterman score: 2265; 59.6% identity (79.5% similar) in 537 aa overlap (274-806:8-522) 250 260 270 280 290 300 pF1KB6 NPKERGFWYDAEISRKRETRTARELYANVVLGDD-SLNDCRIIFVDEVFKIERPGEGSPM ::.. .::::.:: :::.::::::: . :. XP_016 MLVSVFNLGSEGTLNDCKIISVDEIFKIERPG-AHPL 10 20 30 310 320 330 340 350 360 pF1KB6 --VDNPMRRKSGPSCKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIYCLDP .:. . :.. : : : : .. :. :.:..:::...:. ::.::::..:.:::::.: XP_016 SFADGKFLRRNDPECDLCGGDPEKKCHSCSCRVCGGKHEPNMQLLCDECNVAYHIYCLNP 40 50 60 70 80 90 370 380 390 400 410 420 pF1KB6 PLSSVPSEDEWYCPECRNDASEVVLAGERLRESKKKAKMASATSSSQRDWGKGMACVGRT ::..:: :. :::: :..:.:::: :::::. ::::::: ::.. :.::::.:::::::: XP_016 PLDKVPEEEYWYCPSCKTDSSEVVKAGERLKMSKKKAKMPSASTESRRDWGRGMACVGRT 100 110 120 130 140 150 430 440 450 460 470 480 pF1KB6 KECTIVPSNHYGPIPGIPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYE .:::::::::::::::::::. :::::::::.:::::::.::::::::::::::::::. XP_016 RECTIVPSNHYGPIPGIPVGSTWRFRVQVSEAGVHRPHVGGIHGRSNDGAYSLVLAGGFA 160 170 180 190 200 210 490 500 510 520 530 540 pF1KB6 DDVDHGNFFTYTGSGGRDLSGNKRTAEQSCDQKLTNTNRALALNCFAPINDQEGAEAKDW :.::.:. ::::::::..:.:::: . : :: ::: :::::::: ::..:. :::...: XP_016 DEVDRGDEFTYTGSGGKNLAGNKRIGAPSADQTLTNMNRALALNCDAPLDDKIGAESRNW 220 230 240 250 260 270 550 560 570 580 590 pF1KB6 RSGKPVRVVRNVKGGKNSKYAPAEGNRYDGIYKVVKYWPEKGKS-GFLVWRYLLRRDDDE :.::::::.:. :: : ::::: ::::::::::::::::: ..: ::::::::::::: : XP_016 RAGKPVRVIRSFKGRKISKYAPEEGNRYDGIYKVVKYWPEISSSHGFLVWRYLLRRDDVE 280 290 300 310 320 330 600 610 620 630 640 650 pF1KB6 PGPWTKEGKDRIKKLGLTMQYPEGYLEALANREREKENSKREEEEQQEGGFASPRTGKGK :.:::.:: .: ..: : .::: :: ..: .. : . ..: : : XP_016 PAPWTSEGIERSRRLCLRLQYPAGY-----PSDKEGKKPKGQSKKQPSGTTKRP------ 340 350 360 370 380 660 670 680 690 700 710 pF1KB6 WKRKSAGGGPSRAGSPRRTSKKTKVEPYSLTAQQSSLIREDKSNAKLWNEVLASLKDRPA : :: . . ... .: ..:: ::. ::::: .: :::.:::. : . : XP_016 ---ISDDDCPSASKVYKASDSAEAIEAFQLTPQQQHLIREDCQNQKLWDEVLSHLVEGPN 390 400 410 420 430 440 720 730 740 750 760 770 pF1KB6 SGSPFQLFLSKVEETFQCICCQELVFRPITTVCQHNVCKDCLDRSFRAQVFSCPACRYDL ::.:.:..:.:.::::::..:.:: : ::::::::.:::.::::::::::.:: XP_016 -------FLKKLEQSFMCVCCQELVYQPVTTECFHNVCKDCLQRSFKAQVFSCPACRHDL 450 460 470 480 490 780 790 800 pF1KB6 GRSYAMQVNQPLQTVLNQLFPGYGNGR :..: : :. :::.:. .::::..:: XP_016 GQNYIMIPNEILQTLLDLFFPGYSKGR 500 510 520 806 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 16:10:48 2016 done: Mon Nov 7 16:10:49 2016 Total Scan time: 11.210 Total Display time: 0.220 Function used was FASTA [36.3.4 Apr, 2011]