Result of FASTA (omim) for
pFN21AE1600
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1600, 2231 aa
1>>>pF1KE1600 2231 - 2231 aa - 2231 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 16.4435+/-0.000514; mu= -23.7530+/- 0.032
mean_var=810.5030+/-167.017, 0's: 0 Z-trim(124.8): 296 B-trim: 0 in 0/59
Lambda= 0.045050
statistics sampled from 46920 (47272) to 46920 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.784), E-opt: 0.2 (0.554), width: 16
Scan time: 20.610
The best scores are: opt bits E(85289)
XP_005267126 (OMIM: 135900,614556,614562) PREDICTE (2289) 15560 1028.5 0
XP_016866593 (OMIM: 135900,614556,614562) PREDICTE (2316) 11536 767.0 0
XP_016866598 (OMIM: 135900,614556,614562) PREDICTE (1539) 10595 705.7 1.1e-201
XP_016866596 (OMIM: 135900,614556,614562) PREDICTE (2256) 10415 694.1 4.7e-198
XP_016866592 (OMIM: 135900,614556,614562) PREDICTE (2326) 9674 646.0 1.5e-183
XP_011534286 (OMIM: 135900,614556,614562) PREDICTE (2359) 9663 645.3 2.5e-183
XP_016866594 (OMIM: 135900,614556,614562) PREDICTE (2306) 9625 642.8 1.4e-182
XP_011534290 (OMIM: 135900,614556,614562) PREDICTE (1336) 9147 611.5 2.1e-173
XP_016866595 (OMIM: 135900,614556,614562) PREDICTE (2263) 8832 591.3 4.4e-167
NP_059989 (OMIM: 135900,614556,614562) AT-rich int (2236) 8763 586.8 9.8e-166
NP_065783 (OMIM: 135900,614556,614562) AT-rich int (2249) 8750 585.9 1.8e-165
XP_016866597 (OMIM: 135900,614556,614562) PREDICTE (1551) 4020 278.4 4.7e-73
NP_006006 (OMIM: 603024,614607) AT-rich interactiv (2285) 3826 265.9 3.9e-69
NP_624361 (OMIM: 603024,614607) AT-rich interactiv (2068) 3360 235.6 4.7e-60
NP_000079 (OMIM: 114000,120150,130000,130060,16620 (1464) 622 57.5 1.4e-06
XP_011522643 (OMIM: 114000,120150,130000,130060,16 (1398) 585 55.1 7e-06
NP_000081 (OMIM: 120180,130020,130050) collagen al (1466) 578 54.6 9.9e-06
XP_011508860 (OMIM: 120131,203780) PREDICTED: coll (1654) 548 52.7 4.2e-05
XP_016869755 (OMIM: 120215,130000) PREDICTED: coll (1715) 527 51.4 0.00011
NP_001265003 (OMIM: 120215,130000) collagen alpha- (1838) 527 51.4 0.00012
NP_000084 (OMIM: 120215,130000) collagen alpha-1(V (1838) 527 51.4 0.00012
XP_016874320 (OMIM: 108300,120140,132450,150600,15 (1305) 513 50.4 0.00017
NP_149162 (OMIM: 108300,120140,132450,150600,15121 (1418) 513 50.4 0.00018
XP_016874319 (OMIM: 108300,120140,132450,150600,15 (1465) 513 50.4 0.00019
NP_001835 (OMIM: 108300,120140,132450,150600,15121 (1487) 513 50.4 0.00019
XP_016874318 (OMIM: 108300,120140,132450,150600,15 (1534) 513 50.4 0.00019
XP_016874317 (OMIM: 108300,120140,132450,150600,15 (1535) 513 50.4 0.00019
XP_005246334 (OMIM: 104200,120070,141200,203780) P (1635) 505 49.9 0.00029
XP_011536691 (OMIM: 601234) PREDICTED: nascent pol (2078) 505 50.0 0.00034
XP_006719476 (OMIM: 601234) PREDICTED: nascent pol (2082) 505 50.0 0.00034
XP_006719477 (OMIM: 601234) PREDICTED: nascent pol (2082) 505 50.0 0.00034
XP_006719475 (OMIM: 601234) PREDICTED: nascent pol (2082) 505 50.0 0.00034
NP_872363 (OMIM: 609004) B-cell CLL/lymphoma 9-lik (1499) 497 49.4 0.00039
XP_006718878 (OMIM: 609004) PREDICTED: B-cell CLL/ (1499) 497 49.4 0.00039
XP_005271568 (OMIM: 609004) PREDICTED: B-cell CLL/ (1499) 497 49.4 0.00039
XP_016873063 (OMIM: 609004) PREDICTED: B-cell CLL/ (1513) 497 49.4 0.00039
XP_011541058 (OMIM: 609004) PREDICTED: B-cell CLL/ (1514) 497 49.4 0.00039
XP_016873062 (OMIM: 609004) PREDICTED: B-cell CLL/ (1544) 497 49.4 0.0004
XP_016873061 (OMIM: 609004) PREDICTED: B-cell CLL/ (1547) 497 49.4 0.0004
XP_005271570 (OMIM: 609004) PREDICTED: B-cell CLL/ (1462) 496 49.3 0.0004
XP_005271569 (OMIM: 609004) PREDICTED: B-cell CLL/ (1462) 496 49.3 0.0004
XP_016858786 (OMIM: 120131,203780) PREDICTED: coll (1651) 496 49.4 0.00044
XP_011508875 (OMIM: 120190,130000) PREDICTED: coll (1453) 486 48.7 0.00062
NP_000384 (OMIM: 120190,130000) collagen alpha-2(V (1499) 486 48.7 0.00064
XP_011508858 (OMIM: 104200,120070,141200,203780) P (1257) 469 47.5 0.0012
XP_011508857 (OMIM: 104200,120070,141200,203780) P (1609) 469 47.6 0.0014
NP_000082 (OMIM: 104200,120070,141200,203780) coll (1670) 469 47.6 0.0015
XP_011526344 (OMIM: 120216) PREDICTED: collagen al (1744) 468 47.6 0.0016
NP_056534 (OMIM: 120216) collagen alpha-3(V) chain (1745) 468 47.6 0.0016
XP_011508874 (OMIM: 120131,203780) PREDICTED: coll (1132) 451 46.3 0.0025
>>XP_005267126 (OMIM: 135900,614556,614562) PREDICTED: A (2289 aa)
initn: 15560 init1: 15560 opt: 15560 Z-score: 5483.8 bits: 1028.5 E(85289): 0
Smith-Waterman score: 15560; 100.0% identity (100.0% similar) in 2231 aa overlap (1-2231:59-2289)
10 20 30
pF1KE1 METGLLPNHKLKTVGEAPAAPPHQQHHHHH
::::::::::::::::::::::::::::::
XP_005 GSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHH
30 40 50 60 70 80
40 50 60 70 80 90
pF1KE1 HAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAP
90 100 110 120 130 140
100 110 120 130 140 150
pF1KE1 QPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGAL
150 160 170 180 190 200
160 170 180 190 200 210
pF1KE1 GTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHS
210 220 230 240 250 260
220 230 240 250 260 270
pF1KE1 ASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGG
270 280 290 300 310 320
280 290 300 310 320 330
pF1KE1 AGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAA
330 340 350 360 370 380
340 350 360 370 380 390
pF1KE1 SLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPP
390 400 410 420 430 440
400 410 420 430 440 450
pF1KE1 PPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGP
450 460 470 480 490 500
460 470 480 490 500 510
pF1KE1 TMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPG
510 520 530 540 550 560
520 530 540 550 560 570
pF1KE1 AMAGMQYPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AMAGMQYPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQ
570 580 590 600 610 620
580 590 600 610 620 630
pF1KE1 QDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVS
630 640 650 660 670 680
640 650 660 670 680 690
pF1KE1 ASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPG
690 700 710 720 730 740
700 710 720 730 740 750
pF1KE1 SQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPG
750 760 770 780 790 800
760 770 780 790 800 810
pF1KE1 GQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQ
810 820 830 840 850 860
820 830 840 850 860 870
pF1KE1 MHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRK
870 880 890 900 910 920
880 890 900 910 920 930
pF1KE1 AQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAP
930 940 950 960 970 980
940 950 960 970 980 990
pF1KE1 AMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGN
990 1000 1010 1020 1030 1040
1000 1010 1020 1030 1040 1050
pF1KE1 LPVPSPMSPSSASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LPVPSPMSPSSASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPE
1050 1060 1070 1080 1090 1100
1060 1070 1080 1090 1100 1110
pF1KE1 RKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATN
1110 1120 1130 1140 1150 1160
1120 1130 1140 1150 1160 1170
pF1KE1 LNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGS
1170 1180 1190 1200 1210 1220
1180 1190 1200 1210 1220 1230
pF1KE1 LQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSF
1230 1240 1250 1260 1270 1280
1240 1250 1260 1270 1280 1290
pF1KE1 PKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQD
1290 1300 1310 1320 1330 1340
1300 1310 1320 1330 1340 1350
pF1KE1 MYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQ
1350 1360 1370 1380 1390 1400
1360 1370 1380 1390 1400 1410
pF1KE1 QPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYS
1410 1420 1430 1440 1450 1460
1420 1430 1440 1450 1460 1470
pF1KE1 RERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAP
1470 1480 1490 1500 1510 1520
1480 1490 1500 1510 1520 1530
pF1KE1 PYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPN
1530 1540 1550 1560 1570 1580
1540 1550 1560 1570 1580 1590
pF1KE1 HISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITF
1590 1600 1610 1620 1630 1640
1600 1610 1620 1630 1640 1650
pF1KE1 PPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTV
1650 1660 1670 1680 1690 1700
1660 1670 1680 1690 1700 1710
pF1KE1 ATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDS
1710 1720 1730 1740 1750 1760
1720 1730 1740 1750 1760 1770
pF1KE1 GKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLP
1770 1780 1790 1800 1810 1820
1780 1790 1800 1810 1820 1830
pF1KE1 IKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPP
1830 1840 1850 1860 1870 1880
1840 1850 1860 1870 1880 1890
pF1KE1 PLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQ
1890 1900 1910 1920 1930 1940
1900 1910 1920 1930 1940 1950
pF1KE1 QAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKH
1950 1960 1970 1980 1990 2000
1960 1970 1980 1990 2000 2010
pF1KE1 PGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTL
2010 2020 2030 2040 2050 2060
2020 2030 2040 2050 2060 2070
pF1KE1 ANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCK
2070 2080 2090 2100 2110 2120
2080 2090 2100 2110 2120 2130
pF1KE1 LSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARA
2130 2140 2150 2160 2170 2180
2140 2150 2160 2170 2180 2190
pF1KE1 IAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARV
2190 2200 2210 2220 2230 2240
2200 2210 2220 2230
pF1KE1 DENRSEFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL
:::::::::::::::::::::::::::::::::::::::::
XP_005 DENRSEFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL
2250 2260 2270 2280
>>XP_016866593 (OMIM: 135900,614556,614562) PREDICTED: A (2316 aa)
initn: 14907 init1: 11156 opt: 11536 Z-score: 4070.3 bits: 767.0 E(85289): 0
Smith-Waterman score: 15486; 98.8% identity (98.8% similar) in 2258 aa overlap (1-2231:59-2316)
10 20 30
pF1KE1 METGLLPNHKLKTVGEAPAAPPHQQHHHHH
::::::::::::::::::::::::::::::
XP_016 GSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHH
30 40 50 60 70 80
40 50 60 70 80 90
pF1KE1 HAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAP
90 100 110 120 130 140
100 110 120 130 140 150
pF1KE1 QPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGAL
150 160 170 180 190 200
160 170 180 190 200 210
pF1KE1 GTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHS
210 220 230 240 250 260
220 230 240 250 260 270
pF1KE1 ASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGG
270 280 290 300 310 320
280 290 300 310 320 330
pF1KE1 AGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAA
330 340 350 360 370 380
340 350 360 370 380 390
pF1KE1 SLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPP
390 400 410 420 430 440
400 410 420 430 440 450
pF1KE1 PPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGP
450 460 470 480 490 500
460 470 480 490 500 510
pF1KE1 TMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPG
510 520 530 540 550 560
520 530 540 550
pF1KE1 AMAGMQYPQQQ-------------MPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQ
::::::::::: ::::::::::::::::::::::::::::::::::::
XP_016 AMAGMQYPQQQDSGDATWKETFWLMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQ
570 580 590 600 610 620
560 570 580 590 600
pF1KE1 YLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLP---------
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPVEVLASEDA
630 640 650 660 670 680
610 620 630 640 650 660
pF1KE1 -----DLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGG
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFGLKDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGG
690 700 710 720 730 740
670 680 690 700 710 720
pF1KE1 PSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMA
750 760 770 780 790 800
730 740 750 760 770 780
pF1KE1 GTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYS
810 820 830 840 850 860
790 800 810 820 830 840
pF1KE1 RPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMS
870 880 890 900 910 920
850 860 870 880 890 900
pF1KE1 SMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMA
930 940 950 960 970 980
910 920 930 940 950 960
pF1KE1 SSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKE
990 1000 1010 1020 1030 1040
970 980 990 1000 1010 1020
pF1KE1 EGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPKT
1050 1060 1070 1080 1090 1100
1030 1040 1050 1060 1070 1080
pF1KE1 PSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLF
1110 1120 1130 1140 1150 1160
1090 1100 1110 1120 1130 1140
pF1KE1 RLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEE
1170 1180 1190 1200 1210 1220
1150 1160 1170 1180 1190 1200
pF1KE1 PPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHG
1230 1240 1250 1260 1270 1280
1210 1220 1230 1240 1250 1260
pF1KE1 QMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDP
1290 1300 1310 1320 1330 1340
1270 1280 1290 1300 1310 1320
pF1KE1 FGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEP
1350 1360 1370 1380 1390 1400
1330 1340 1350 1360 1370 1380
pF1KE1 YGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQ
1410 1420 1430 1440 1450 1460
1390 1400 1410 1420 1430 1440
pF1KE1 EMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQ
1470 1480 1490 1500 1510 1520
1450 1460 1470 1480 1490 1500
pF1KE1 QNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQP
1530 1540 1550 1560 1570 1580
1510 1520 1530 1540 1550 1560
pF1KE1 YMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQ
1590 1600 1610 1620 1630 1640
1570 1580 1590 1600 1610 1620
pF1KE1 KVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMM
1650 1660 1670 1680 1690 1700
1630 1640 1650 1660 1670 1680
pF1KE1 SLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEY
1710 1720 1730 1740 1750 1760
1690 1700 1710 1720 1730 1740
pF1KE1 EVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKS
1770 1780 1790 1800 1810 1820
1750 1760 1770 1780 1790 1800
pF1KE1 SIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQL
1830 1840 1850 1860 1870 1880
1810 1820 1830 1840 1850 1860
pF1KE1 GGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVL
1890 1900 1910 1920 1930 1940
1870 1880 1890 1900 1910 1920
pF1KE1 SARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSL
1950 1960 1970 1980 1990 2000
1930 1940 1950 1960 1970 1980
pF1KE1 AKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDE
2010 2020 2030 2040 2050 2060
1990 2000 2010 2020 2030 2040
pF1KE1 DKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSA
2070 2080 2090 2100 2110 2120
2050 2060 2070 2080 2090 2100
pF1KE1 EAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGD
2130 2140 2150 2160 2170 2180
2110 2120 2130 2140 2150 2160
pF1KE1 RKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMH
2190 2200 2210 2220 2230 2240
2170 2180 2190 2200 2210 2220
pF1KE1 MQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICD
2250 2260 2270 2280 2290 2300
2230
pF1KE1 VLFQIGQL
::::::::
XP_016 VLFQIGQL
2310
>>XP_016866598 (OMIM: 135900,614556,614562) PREDICTED: A (1539 aa)
initn: 10595 init1: 10595 opt: 10595 Z-score: 3742.1 bits: 705.7 E(85289): 1.1e-201
Smith-Waterman score: 10595; 100.0% identity (100.0% similar) in 1539 aa overlap (693-2231:1-1539)
670 680 690 700 710 720
pF1KE1 GPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFM
::::::::::::::::::::::::::::::
XP_016 MPPQPPGSQSESSSHPALSQSPMPQERGFM
10 20 30
730 740 750 760 770 780
pF1KE1 AGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNY
40 50 60 70 80 90
790 800 810 820 830 840
pF1KE1 SRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNM
100 110 120 130 140 150
850 860 870 880 890 900
pF1KE1 SSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLM
160 170 180 190 200 210
910 920 930 940 950 960
pF1KE1 ASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGK
220 230 240 250 260 270
970 980 990 1000 1010 1020
pF1KE1 EEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPK
280 290 300 310 320 330
1030 1040 1050 1060 1070 1080
pF1KE1 TPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDL
340 350 360 370 380 390
1090 1100 1110 1120 1130 1140
pF1KE1 FRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGE
400 410 420 430 440 450
1150 1160 1170 1180 1190 1200
pF1KE1 EPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPH
460 470 480 490 500 510
1210 1220 1230 1240 1250 1260
pF1KE1 GQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKD
520 530 540 550 560 570
1270 1280 1290 1300 1310 1320
pF1KE1 PFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHE
580 590 600 610 620 630
1330 1340 1350 1360 1370 1380
pF1KE1 PYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQ
640 650 660 670 680 690
1390 1400 1410 1420 1430 1440
pF1KE1 QEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGP
700 710 720 730 740 750
1450 1460 1470 1480 1490 1500
pF1KE1 QQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQ
760 770 780 790 800 810
1510 1520 1530 1540 1550 1560
pF1KE1 PYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKM
820 830 840 850 860 870
1570 1580 1590 1600 1610 1620
pF1KE1 QKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVM
880 890 900 910 920 930
1630 1640 1650 1660 1670 1680
pF1KE1 MSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILME
940 950 960 970 980 990
1690 1700 1710 1720 1730 1740
pF1KE1 YEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEK
1000 1010 1020 1030 1040 1050
1750 1760 1770 1780 1790 1800
pF1KE1 SSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQ
1060 1070 1080 1090 1100 1110
1810 1820 1830 1840 1850 1860
pF1KE1 LGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDV
1120 1130 1140 1150 1160 1170
1870 1880 1890 1900 1910 1920
pF1KE1 LSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDS
1180 1190 1200 1210 1220 1230
1930 1940 1950 1960 1970 1980
pF1KE1 LAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEED
1240 1250 1260 1270 1280 1290
1990 2000 2010 2020 2030 2040
pF1KE1 EDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPS
1300 1310 1320 1330 1340 1350
2050 2060 2070 2080 2090 2100
pF1KE1 AEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVG
1360 1370 1380 1390 1400 1410
2110 2120 2130 2140 2150 2160
pF1KE1 DRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLM
1420 1430 1440 1450 1460 1470
2170 2180 2190 2200 2210 2220
pF1KE1 HMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVIC
1480 1490 1500 1510 1520 1530
2230
pF1KE1 DVLFQIGQL
:::::::::
XP_016 DVLFQIGQL
>>XP_016866596 (OMIM: 135900,614556,614562) PREDICTED: A (2256 aa)
initn: 14388 init1: 10008 opt: 10415 Z-score: 3676.7 bits: 694.1 E(85289): 4.7e-198
Smith-Waterman score: 14923; 96.1% identity (96.1% similar) in 2258 aa overlap (1-2231:59-2256)
10 20 30
pF1KE1 METGLLPNHKLKTVGEAPAAPPHQQHHHHH
::::::::::::::::::::::::::::::
XP_016 GSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHH
30 40 50 60 70 80
40 50 60 70 80 90
pF1KE1 HAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAP
90 100 110 120 130 140
100 110 120 130 140 150
pF1KE1 QPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGAL
150 160 170 180 190 200
160 170 180 190 200 210
pF1KE1 GTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHS
210 220 230 240 250 260
220 230 240 250 260 270
pF1KE1 ASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGG
270 280 290 300 310 320
280 290 300 310 320 330
pF1KE1 AGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAA
330 340 350 360 370 380
340 350 360 370 380 390
pF1KE1 SLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPP
390 400 410 420 430 440
400 410 420 430 440 450
pF1KE1 PPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGP
450 460 470 480 490 500
460 470 480 490 500 510
pF1KE1 TMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPG
510 520 530 540 550 560
520 530 540 550
pF1KE1 AMAGMQYPQQQ-------------MPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQ
::::::::::: ::::::::::::::::::::::::::::::::::::
XP_016 AMAGMQYPQQQDSGDATWKETFWLMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQ
570 580 590 600 610 620
560 570 580 590 600
pF1KE1 YLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLP---------
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPVEVLASEDA
630 640 650 660 670 680
610 620 630 640 650 660
pF1KE1 -----DLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGG
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFGLKDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGG
690 700 710 720 730 740
670 680 690 700 710 720
pF1KE1 PSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERG---
750 760 770 780 790 800
730 740 750 760 770 780
pF1KE1 GTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYS
:::
XP_016 ---------------------------------------------------------NYS
790 800 810 820 830 840
pF1KE1 RPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMS
810 820 830 840 850 860
850 860 870 880 890 900
pF1KE1 SMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMA
870 880 890 900 910 920
910 920 930 940 950 960
pF1KE1 SSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKE
930 940 950 960 970 980
970 980 990 1000 1010 1020
pF1KE1 EGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPKT
990 1000 1010 1020 1030 1040
1030 1040 1050 1060 1070 1080
pF1KE1 PSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLF
1050 1060 1070 1080 1090 1100
1090 1100 1110 1120 1130 1140
pF1KE1 RLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEE
1110 1120 1130 1140 1150 1160
1150 1160 1170 1180 1190 1200
pF1KE1 PPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHG
1170 1180 1190 1200 1210 1220
1210 1220 1230 1240 1250 1260
pF1KE1 QMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDP
1230 1240 1250 1260 1270 1280
1270 1280 1290 1300 1310 1320
pF1KE1 FGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEP
1290 1300 1310 1320 1330 1340
1330 1340 1350 1360 1370 1380
pF1KE1 YGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQ
1350 1360 1370 1380 1390 1400
1390 1400 1410 1420 1430 1440
pF1KE1 EMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQ
1410 1420 1430 1440 1450 1460
1450 1460 1470 1480 1490 1500
pF1KE1 QNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQP
1470 1480 1490 1500 1510 1520
1510 1520 1530 1540 1550 1560
pF1KE1 YMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQ
1530 1540 1550 1560 1570 1580
1570 1580 1590 1600 1610 1620
pF1KE1 KVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMM
1590 1600 1610 1620 1630 1640
1630 1640 1650 1660 1670 1680
pF1KE1 SLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEY
1650 1660 1670 1680 1690 1700
1690 1700 1710 1720 1730 1740
pF1KE1 EVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKS
1710 1720 1730 1740 1750 1760
1750 1760 1770 1780 1790 1800
pF1KE1 SIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQL
1770 1780 1790 1800 1810 1820
1810 1820 1830 1840 1850 1860
pF1KE1 GGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVL
1830 1840 1850 1860 1870 1880
1870 1880 1890 1900 1910 1920
pF1KE1 SARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSL
1890 1900 1910 1920 1930 1940
1930 1940 1950 1960 1970 1980
pF1KE1 AKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDE
1950 1960 1970 1980 1990 2000
1990 2000 2010 2020 2030 2040
pF1KE1 DKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSA
2010 2020 2030 2040 2050 2060
2050 2060 2070 2080 2090 2100
pF1KE1 EAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGD
2070 2080 2090 2100 2110 2120
2110 2120 2130 2140 2150 2160
pF1KE1 RKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMH
2130 2140 2150 2160 2170 2180
2170 2180 2190 2200 2210 2220
pF1KE1 MQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICD
2190 2200 2210 2220 2230 2240
2230
pF1KE1 VLFQIGQL
::::::::
XP_016 VLFQIGQL
2250
>>XP_016866592 (OMIM: 135900,614556,614562) PREDICTED: A (2326 aa)
initn: 13587 init1: 9207 opt: 9674 Z-score: 3416.2 bits: 646.0 E(85289): 1.5e-183
Smith-Waterman score: 15425; 98.4% identity (98.4% similar) in 2263 aa overlap (6-2231:64-2326)
10 20 30
pF1KE1 METGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHH
::::::::::::::::::::::::::::::
XP_016 LSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHH
40 50 60 70 80 90
40 50 60 70 80 90
pF1KE1 HHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPD
100 110 120 130 140 150
100 110 120 130 140 150
pF1KE1 MEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQP
160 170 180 190 200 210
160 170 180 190 200 210
pF1KE1 PVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAA
220 230 240 250 260 270
220 230 240 250 260 270
pF1KE1 AGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGG
280 290 300 310 320 330
280 290 300 310 320 330
pF1KE1 AGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKA
340 350 360 370 380 390
340 350 360 370 380 390
pF1KE1 AAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQP
400 410 420 430 440 450
400 410 420 430 440 450
pF1KE1 QSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRS
460 470 480 490 500 510
460 470 480 490 500 510
pF1KE1 QGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGM
520 530 540 550 560 570
520 530 540 550 560
pF1KE1 QYPQQQ-------------MPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQ
:::::: :::::::::::::::::::::::::::::::::::::::::
XP_016 QYPQQQDSGDATWKETFWLMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQ
580 590 600 610 620 630
570 580 590 600
pF1KE1 SQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLP--------------
::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPVEVLASEDAAFGLK
640 650 660 670 680 690
610 620 630 640 650 660
pF1KE1 DLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSP
700 710 720 730 740 750
670 680 690 700 710 720
pF1KE1 VGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRN
760 770 780 790 800 810
730 740 750 760 770 780
pF1KE1 PQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAY
820 830 840 850 860 870
790 800 810 820 830 840
pF1KE1 SGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPS
880 890 900 910 920 930
850 860 870 880 890
pF1KE1 SPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSR----------QGSFPGMNQ
::::::::::::::::::::::::::::::::::::::::: :::::::::
XP_016 SPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRYATQEHAPGRQGSFPGMNQ
940 950 960 970 980 990
900 910 920 930 940 950
pF1KE1 SGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLK
1000 1010 1020 1030 1040 1050
960 970 980 990 1000 1010
pF1KE1 ADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSP
1060 1070 1080 1090 1100 1110
1020 1030 1040 1050 1060 1070
pF1KE1 GWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKK
1120 1130 1140 1150 1160 1170
1080 1090 1100 1110 1120 1130
pF1KE1 PLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKI
1180 1190 1200 1210 1220 1230
1140 1150 1160 1170 1180 1190
pF1KE1 ERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPA
1240 1250 1260 1270 1280 1290
1200 1210 1220 1230 1240 1250
pF1KE1 STPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYE
1300 1310 1320 1330 1340 1350
1260 1270 1280 1290 1300 1310
pF1KE1 PNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYD
1360 1370 1380 1390 1400 1410
1320 1330 1340 1350 1360 1370
pF1KE1 RRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQY
1420 1430 1440 1450 1460 1470
1380 1390 1400 1410 1420 1430
pF1KE1 SSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSS
1480 1490 1500 1510 1520 1530
1440 1450 1460 1470 1480 1490
pF1KE1 SEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHV
1540 1550 1560 1570 1580 1590
1500 1510 1520 1530 1540 1550
pF1KE1 SQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLP
1600 1610 1620 1630 1640 1650
1560 1570 1580 1590 1600 1610
pF1KE1 SMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEA
1660 1670 1680 1690 1700 1710
1620 1630 1640 1650 1660 1670
pF1KE1 WRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFG
1720 1730 1740 1750 1760 1770
1680 1690 1700 1710 1720 1730
pF1KE1 ILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTE
1780 1790 1800 1810 1820 1830
1740 1750 1760 1770 1780 1790
pF1KE1 SDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGL
1840 1850 1860 1870 1880 1890
1800 1810 1820 1830 1840 1850
pF1KE1 LHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIAT
1900 1910 1920 1930 1940 1950
1860 1870 1880 1890 1900 1910
pF1KE1 IDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAH
1960 1970 1980 1990 2000 2010
1920 1930 1940 1950 1960 1970
pF1KE1 WQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYE
2020 2030 2040 2050 2060 2070
1980 1990 2000 2010 2020 2030
pF1KE1 KEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWM
2080 2090 2100 2110 2120 2130
2040 2050 2060 2070 2080 2090
pF1KE1 VCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLV
2140 2150 2160 2170 2180 2190
2100 2110 2120 2130 2140 2150
pF1KE1 RYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQ
2200 2210 2220 2230 2240 2250
2160 2170 2180 2190 2200 2210
pF1KE1 HNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVA
2260 2270 2280 2290 2300 2310
2220 2230
pF1KE1 SVICDVLFQIGQL
:::::::::::::
XP_016 SVICDVLFQIGQL
2320
>>XP_011534286 (OMIM: 135900,614556,614562) PREDICTED: A (2359 aa)
initn: 14893 init1: 9193 opt: 9663 Z-score: 3412.3 bits: 645.3 E(85289): 2.5e-183
Smith-Waterman score: 15092; 96.9% identity (96.9% similar) in 2263 aa overlap (39-2231:97-2359)
10 20 30 40 50 60
pF1KE1 HKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQ
::::::::::::::::::::::::::::::
XP_011 HKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQ
70 80 90 100 110 120
70 80 90 100 110 120
pF1KE1 QQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDED
130 140 150 160 170 180
130 140 150 160 170 180
pF1KE1 DAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGG
190 200 210 220 230 240
190 200 210 220 230 240
pF1KE1 RAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGA
250 260 270 280 290 300
250 260 270 280 290 300
pF1KE1 GGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYG
310 320 330 340 350 360
310 320 330 340 350 360
pF1KE1 VLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSP
370 380 390 400 410 420
370 380 390 400 410 420
pF1KE1 SPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAA
430 440 450 460 470 480
430 440 450 460 470 480
pF1KE1 SPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYP
490 500 510 520 530 540
490 500 510 520 530
pF1KE1 GGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQ-------------MPPQYGQQGVSGYC
::::::::::::::::::::::::::::::::: ::::::::::::::
XP_011 GGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQGVSGYC
550 560 570 580 590 600
540 550 560 570 580 590
pF1KE1 QQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHED
610 620 630 640 650 660
600 610 620 630 640
pF1KE1 LNLIQQERPSSLP--------------DLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQ
::::::::::::: :::::::::::::::::::::::::::::::::
XP_011 LNLIQQERPSSLPVEVLASEDAAFGLKDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQ
670 680 690 700 710 720
650 660 670 680 690 700
pF1KE1 SNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQ
730 740 750 760 770 780
710 720 730 740 750 760
pF1KE1 SESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQ
790 800 810 820 830 840
770 780 790 800 810 820
pF1KE1 QSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCG
850 860 870 880 890 900
830 840 850 860 870 880
pF1KE1 AVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQA
910 920 930 940 950 960
890
pF1KE1 AANSAQSR-------------------------------------------QGSFPGMNQ
:::::::: :::::::::
XP_011 AANSAQSRPPYIRSPAYPSQSGAGGRPMFSSQHPNYGNSQAPMVHQPDQYGQGSFPGMNQ
970 980 990 1000 1010 1020
900 910 920 930 940 950
pF1KE1 SGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLK
1030 1040 1050 1060 1070 1080
960 970 980 990 1000 1010
pF1KE1 ADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSP
1090 1100 1110 1120 1130 1140
1020 1030 1040 1050 1060 1070
pF1KE1 GWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKK
1150 1160 1170 1180 1190 1200
1080 1090 1100 1110 1120 1130
pF1KE1 PLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKI
1210 1220 1230 1240 1250 1260
1140 1150 1160 1170 1180 1190
pF1KE1 ERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPA
1270 1280 1290 1300 1310 1320
1200 1210 1220 1230 1240 1250
pF1KE1 STPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYE
1330 1340 1350 1360 1370 1380
1260 1270 1280 1290 1300 1310
pF1KE1 PNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYD
1390 1400 1410 1420 1430 1440
1320 1330 1340 1350 1360 1370
pF1KE1 RRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQY
1450 1460 1470 1480 1490 1500
1380 1390 1400 1410 1420 1430
pF1KE1 SSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSS
1510 1520 1530 1540 1550 1560
1440 1450 1460 1470 1480 1490
pF1KE1 SEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHV
1570 1580 1590 1600 1610 1620
1500 1510 1520 1530 1540 1550
pF1KE1 SQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLP
1630 1640 1650 1660 1670 1680
1560 1570 1580 1590 1600 1610
pF1KE1 SMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEA
1690 1700 1710 1720 1730 1740
1620 1630 1640 1650 1660 1670
pF1KE1 WRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFG
1750 1760 1770 1780 1790 1800
1680 1690 1700 1710 1720 1730
pF1KE1 ILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTE
1810 1820 1830 1840 1850 1860
1740 1750 1760 1770 1780 1790
pF1KE1 SDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGL
1870 1880 1890 1900 1910 1920
1800 1810 1820 1830 1840 1850
pF1KE1 LHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIAT
1930 1940 1950 1960 1970 1980
1860 1870 1880 1890 1900 1910
pF1KE1 IDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAH
1990 2000 2010 2020 2030 2040
1920 1930 1940 1950 1960 1970
pF1KE1 WQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYE
2050 2060 2070 2080 2090 2100
1980 1990 2000 2010 2020 2030
pF1KE1 KEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWM
2110 2120 2130 2140 2150 2160
2040 2050 2060 2070 2080 2090
pF1KE1 VCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLV
2170 2180 2190 2200 2210 2220
2100 2110 2120 2130 2140 2150
pF1KE1 RYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQ
2230 2240 2250 2260 2270 2280
2160 2170 2180 2190 2200 2210
pF1KE1 HNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVA
2290 2300 2310 2320 2330 2340
2220 2230
pF1KE1 SVICDVLFQIGQL
:::::::::::::
XP_011 SVICDVLFQIGQL
2350
>>XP_016866594 (OMIM: 135900,614556,614562) PREDICTED: A (2306 aa)
initn: 13964 init1: 8264 opt: 9625 Z-score: 3399.1 bits: 642.8 E(85289): 1.4e-182
Smith-Waterman score: 14902; 94.7% identity (94.7% similar) in 2301 aa overlap (1-2231:59-2306)
10 20 30
pF1KE1 METGLLPNHKLKTVGEAPAAPPHQQHHHHH
::::::::::::::::::::::::::::::
XP_016 GSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHH
30 40 50 60 70 80
40 50 60 70 80 90
pF1KE1 HAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAP
90 100 110 120 130 140
100 110 120 130 140 150
pF1KE1 QPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGAL
150 160 170 180 190 200
160 170 180 190 200 210
pF1KE1 GTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHS
210 220 230 240 250 260
220 230 240 250 260 270
pF1KE1 ASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGG
270 280 290 300 310 320
280 290 300 310 320 330
pF1KE1 AGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAA
330 340 350 360 370 380
340 350 360 370 380 390
pF1KE1 SLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPP
390 400 410 420 430 440
400 410 420 430 440 450
pF1KE1 PPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGP
450 460 470 480 490 500
460 470 480 490 500 510
pF1KE1 TMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPG
510 520 530 540 550 560
520 530 540 550
pF1KE1 AMAGMQYPQQQ-------------MPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQ
::::::::::: ::::::::::::::::::::::::::::::::::::
XP_016 AMAGMQYPQQQDSGDATWKETFWLMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQ
570 580 590 600 610 620
560 570 580 590 600
pF1KE1 YLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLP---------
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPVEVLASEDA
630 640 650 660 670 680
610 620 630 640 650 660
pF1KE1 -----DLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGG
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFGLKDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGG
690 700 710 720 730 740
670 680 690 700 710 720
pF1KE1 PSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMA
750 760 770 780 790 800
730 740 750 760 770 780
pF1KE1 GTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYS
810 820 830 840 850 860
790 800 810 820 830 840
pF1KE1 RPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMS
870 880 890 900 910 920
850 860 870 880
pF1KE1 SMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSR--------------
::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRPPYIRSPAYPSQSG
930 940 950 960 970 980
890 900 910 920
pF1KE1 -----------------------------QGSFPGMNQSGLMASSSPYSQPMNNSSSLMN
:::::::::::::::::::::::::::::::
XP_016 AGGRPMFSSQHPNYGNSQAPMVHQPDQYGQGSFPGMNQSGLMASSSPYSQPMNNSSSLMN
990 1000 1010 1020 1030 1040
930 940 950 960 970 980
pF1KE1 TQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSK------
1050 1060 1070 1080 1090 1100
990 1000 1010 1020 1030 1040
pF1KE1 GISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKIT
:::::::::::::
XP_016 -----------------------------------------------KSSSSTTTGEKIT
1110
1050 1060 1070 1080 1090 1100
pF1KE1 KVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNK
1120 1130 1140 1150 1160 1170
1110 1120 1130 1140 1150 1160
pF1KE1 NKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKL
1180 1190 1200 1210 1220 1230
1170 1180 1190 1200 1210 1220
pF1KE1 QPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHD
1240 1250 1260 1270 1280 1290
1230 1240 1250 1260 1270 1280
pF1KE1 PFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQ
1300 1310 1320 1330 1340 1350
1290 1300 1310 1320 1330 1340
pF1KE1 GQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPY
1360 1370 1380 1390 1400 1410
1350 1360 1370 1380 1390 1400
pF1KE1 GGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRP
1420 1430 1440 1450 1460 1470
1410 1420 1430 1440 1450 1460
pF1KE1 IQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNR
1480 1490 1500 1510 1520 1530
1470 1480 1490 1500 1510 1520
pF1KE1 QGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQP
1540 1550 1560 1570 1580 1590
1530 1540 1550 1560 1570 1580
pF1KE1 SYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQ
1600 1610 1620 1630 1640 1650
1590 1600 1610 1620 1630 1640
pF1KE1 PPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTI
1660 1670 1680 1690 1700 1710
1650 1660 1670 1680 1690 1700
pF1KE1 NILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARK
1720 1730 1740 1750 1760 1770
1710 1720 1730 1740 1750 1760
pF1KE1 DDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKP
1780 1790 1800 1810 1820 1830
1770 1780 1790 1800 1810 1820
pF1KE1 KQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKM
1840 1850 1860 1870 1880 1890
1830 1840 1850 1860 1870 1880
pF1KE1 EIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQT
1900 1910 1920 1930 1940 1950
1890 1900 1910 1920 1930 1940
pF1KE1 ESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFV
1960 1970 1980 1990 2000 2010
1950 1960 1970 1980 1990 2000
pF1KE1 PGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLE
2020 2030 2040 2050 2060 2070
2010 2020 2030 2040 2050 2060
pF1KE1 VLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSP
2080 2090 2100 2110 2120 2130
2070 2080 2090 2100 2110 2120
pF1KE1 QRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNL
2140 2150 2160 2170 2180 2190
2130 2140 2150 2160 2170 2180
pF1KE1 AQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRA
2200 2210 2220 2230 2240 2250
2190 2200 2210 2220 2230
pF1KE1 AKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL
2260 2270 2280 2290 2300
>>XP_011534290 (OMIM: 135900,614556,614562) PREDICTED: A (1336 aa)
initn: 9147 init1: 9147 opt: 9147 Z-score: 3234.3 bits: 611.5 E(85289): 2.1e-173
Smith-Waterman score: 9147; 100.0% identity (100.0% similar) in 1336 aa overlap (896-2231:1-1336)
870 880 890 900 910 920
pF1KE1 TVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPP
::::::::::::::::::::::::::::::
XP_011 MNQSGLMASSSPYSQPMNNSSSLMNTQAPP
10 20 30
930 940 950 960 970 980
pF1KE1 YSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQP
40 50 60 70 80 90
990 1000 1010 1020 1030 1040
pF1KE1 PTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYEL
100 110 120 130 140 150
1050 1060 1070 1080 1090 1100
pF1KE1 GNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWR
160 170 180 190 200 210
1110 1120 1130 1140 1150 1160
pF1KE1 ELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSP
220 230 240 250 260 270
1170 1180 1190 1200 1210 1220
pF1KE1 ANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDV
280 290 300 310 320 330
1230 1240 1250 1260 1270 1280
pF1KE1 SDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPN
340 350 360 370 380 390
1290 1300 1310 1320 1330 1340
pF1KE1 SSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQP
400 410 420 430 440 450
1350 1360 1370 1380 1390 1400
pF1KE1 GLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQY
460 470 480 490 500 510
1410 1420 1430 1440 1450 1460
pF1KE1 PYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGG
520 530 540 550 560 570
1470 1480 1490 1500 1510 1520
pF1KE1 PTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTP
580 590 600 610 620 630
1530 1540 1550 1560 1570 1580
pF1KE1 PSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIR
640 650 660 670 680 690
1590 1600 1610 1620 1630 1640
pF1KE1 REITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLY
700 710 720 730 740 750
1650 1660 1670 1680 1690 1700
pF1KE1 DDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQS
760 770 780 790 800 810
1710 1720 1730 1740 1750 1760
pF1KE1 LADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASK
820 830 840 850 860 870
1770 1780 1790 1800 1810 1820
pF1KE1 FDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPR
880 890 900 910 920 930
1830 1840 1850 1860 1870 1880
pF1KE1 RRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKF
940 950 960 970 980 990
1890 1900 1910 1920 1930 1940
pF1KE1 PFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDA
1000 1010 1020 1030 1040 1050
1950 1960 1970 1980 1990 2000
pF1KE1 EMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDN
1060 1070 1080 1090 1100 1110
2010 2020 2030 2040 2050 2060
pF1KE1 TLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVL
1120 1130 1140 1150 1160 1170
2070 2080 2090 2100 2110 2120
pF1KE1 ETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDA
1180 1190 1200 1210 1220 1230
2130 2140 2150 2160 2170 2180
pF1KE1 LAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALL
1240 1250 1260 1270 1280 1290
2190 2200 2210 2220 2230
pF1KE1 AMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL
::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL
1300 1310 1320 1330
>>XP_016866595 (OMIM: 135900,614556,614562) PREDICTED: A (2263 aa)
initn: 12644 init1: 8264 opt: 8832 Z-score: 3120.6 bits: 591.3 E(85289): 4.4e-167
Smith-Waterman score: 14998; 96.5% identity (96.5% similar) in 2258 aa overlap (1-2231:59-2263)
10 20 30
pF1KE1 METGLLPNHKLKTVGEAPAAPPHQQHHHHH
::::::::::::::::::::::::::::::
XP_016 GSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHH
30 40 50 60 70 80
40 50 60 70 80 90
pF1KE1 HAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAP
90 100 110 120 130 140
100 110 120 130 140 150
pF1KE1 QPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGAL
150 160 170 180 190 200
160 170 180 190 200 210
pF1KE1 GTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHS
210 220 230 240 250 260
220 230 240 250 260 270
pF1KE1 ASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGG
270 280 290 300 310 320
280 290 300 310 320 330
pF1KE1 AGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAA
330 340 350 360 370 380
340 350 360 370 380 390
pF1KE1 SLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPP
390 400 410 420 430 440
400 410 420 430 440 450
pF1KE1 PPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGP
450 460 470 480 490 500
460 470 480 490 500 510
pF1KE1 TMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPG
510 520 530 540 550 560
520 530 540 550
pF1KE1 AMAGMQYPQQQ-------------MPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQ
::::::::::: ::::::::::::::::::::::::::::::::::::
XP_016 AMAGMQYPQQQDSGDATWKETFWLMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQ
570 580 590 600 610 620
560 570 580 590 600
pF1KE1 YLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLP---------
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPVEVLASEDA
630 640 650 660 670 680
610 620 630 640 650 660
pF1KE1 -----DLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGG
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFGLKDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGG
690 700 710 720 730 740
670 680 690 700 710 720
pF1KE1 PSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMA
750 760 770 780 790 800
730 740 750 760 770 780
pF1KE1 GTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYS
810 820 830 840 850 860
790 800 810 820 830 840
pF1KE1 RPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMS
870 880 890 900 910 920
850 860 870 880 890 900
pF1KE1 SMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMA
930 940 950 960 970 980
910 920 930 940 950 960
pF1KE1 SSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKE
990 1000 1010 1020 1030 1040
970 980 990 1000 1010 1020
pF1KE1 EGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPKT
:::::::::::
XP_016 EGTPQPESKSK-------------------------------------------------
1050
1030 1040 1050 1060 1070 1080
pF1KE1 PSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ----KSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLF
1060 1070 1080 1090 1100 1110
1090 1100 1110 1120 1130 1140
pF1KE1 RLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEE
1120 1130 1140 1150 1160 1170
1150 1160 1170 1180 1190 1200
pF1KE1 PPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHG
1180 1190 1200 1210 1220 1230
1210 1220 1230 1240 1250 1260
pF1KE1 QMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDP
1240 1250 1260 1270 1280 1290
1270 1280 1290 1300 1310 1320
pF1KE1 FGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEP
1300 1310 1320 1330 1340 1350
1330 1340 1350 1360 1370 1380
pF1KE1 YGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQ
1360 1370 1380 1390 1400 1410
1390 1400 1410 1420 1430 1440
pF1KE1 EMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQ
1420 1430 1440 1450 1460 1470
1450 1460 1470 1480 1490 1500
pF1KE1 QNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQP
1480 1490 1500 1510 1520 1530
1510 1520 1530 1540 1550 1560
pF1KE1 YMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQ
1540 1550 1560 1570 1580 1590
1570 1580 1590 1600 1610 1620
pF1KE1 KVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMM
1600 1610 1620 1630 1640 1650
1630 1640 1650 1660 1670 1680
pF1KE1 SLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEY
1660 1670 1680 1690 1700 1710
1690 1700 1710 1720 1730 1740
pF1KE1 EVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKS
1720 1730 1740 1750 1760 1770
1750 1760 1770 1780 1790 1800
pF1KE1 SIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQL
1780 1790 1800 1810 1820 1830
1810 1820 1830 1840 1850 1860
pF1KE1 GGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVL
1840 1850 1860 1870 1880 1890
1870 1880 1890 1900 1910 1920
pF1KE1 SARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSL
1900 1910 1920 1930 1940 1950
1930 1940 1950 1960 1970 1980
pF1KE1 AKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDE
1960 1970 1980 1990 2000 2010
1990 2000 2010 2020 2030 2040
pF1KE1 DKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSA
2020 2030 2040 2050 2060 2070
2050 2060 2070 2080 2090 2100
pF1KE1 EAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGD
2080 2090 2100 2110 2120 2130
2110 2120 2130 2140 2150 2160
pF1KE1 RKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMH
2140 2150 2160 2170 2180 2190
2170 2180 2190 2200 2210 2220
pF1KE1 MQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICD
2200 2210 2220 2230 2240 2250
2230
pF1KE1 VLFQIGQL
::::::::
XP_016 VLFQIGQL
2260
>>NP_059989 (OMIM: 135900,614556,614562) AT-rich interac (2236 aa)
initn: 8264 init1: 8264 opt: 8763 Z-score: 3096.4 bits: 586.8 E(85289): 9.8e-166
Smith-Waterman score: 15072; 97.6% identity (97.6% similar) in 2231 aa overlap (1-2231:59-2236)
10 20 30
pF1KE1 METGLLPNHKLKTVGEAPAAPPHQQHHHHH
::::::::::::::::::::::::::::::
NP_059 GSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHH
30 40 50 60 70 80
40 50 60 70 80 90
pF1KE1 HAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 HAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAP
90 100 110 120 130 140
100 110 120 130 140 150
pF1KE1 QPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 QPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGAL
150 160 170 180 190 200
160 170 180 190 200 210
pF1KE1 GTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 GTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHS
210 220 230 240 250 260
220 230 240 250 260 270
pF1KE1 ASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 ASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGG
270 280 290 300 310 320
280 290 300 310 320 330
pF1KE1 AGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 AGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAA
330 340 350 360 370 380
340 350 360 370 380 390
pF1KE1 SLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 SLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPP
390 400 410 420 430 440
400 410 420 430 440 450
pF1KE1 PPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 PPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGP
450 460 470 480 490 500
460 470 480 490 500 510
pF1KE1 TMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 TMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPG
510 520 530 540 550 560
520 530 540 550 560 570
pF1KE1 AMAGMQYPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 AMAGMQYPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQ
570 580 590 600 610 620
580 590 600 610 620 630
pF1KE1 QDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 QDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVS
630 640 650 660 670 680
640 650 660 670 680 690
pF1KE1 ASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 ASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPG
690 700 710 720 730 740
700 710 720 730 740 750
pF1KE1 SQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 SQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPG
750 760 770 780 790 800
760 770 780 790 800 810
pF1KE1 GQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 GQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQ
810 820 830 840 850 860
820 830 840 850 860 870
pF1KE1 MHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 MHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRK
870 880 890 900 910 920
880 890 900 910 920 930
pF1KE1 AQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 AQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAP
930 940 950 960 970 980
940 950 960 970 980 990
pF1KE1 AMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGN
::::::::::::::::::::::::::::::::::::::::::::
NP_059 AMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSK----------------
990 1000 1010 1020 1030
1000 1010 1020 1030 1040 1050
pF1KE1 LPVPSPMSPSSASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPE
:::::::::::::::::::::::
NP_059 -------------------------------------KSSSSTTTGEKITKVYELGNEPE
1040 1050
1060 1070 1080 1090 1100 1110
pF1KE1 RKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 RKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATN
1060 1070 1080 1090 1100 1110
1120 1130 1140 1150 1160 1170
pF1KE1 LNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 LNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGS
1120 1130 1140 1150 1160 1170
1180 1190 1200 1210 1220 1230
pF1KE1 LQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 LQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSF
1180 1190 1200 1210 1220 1230
1240 1250 1260 1270 1280 1290
pF1KE1 PKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 PKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQD
1240 1250 1260 1270 1280 1290
1300 1310 1320 1330 1340 1350
pF1KE1 MYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 MYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQ
1300 1310 1320 1330 1340 1350
1360 1370 1380 1390 1400 1410
pF1KE1 QPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 QPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYS
1360 1370 1380 1390 1400 1410
1420 1430 1440 1450 1460 1470
pF1KE1 RERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 RERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAP
1420 1430 1440 1450 1460 1470
1480 1490 1500 1510 1520 1530
pF1KE1 PYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 PYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPN
1480 1490 1500 1510 1520 1530
1540 1550 1560 1570 1580 1590
pF1KE1 HISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 HISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITF
1540 1550 1560 1570 1580 1590
1600 1610 1620 1630 1640 1650
pF1KE1 PPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 PPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTV
1600 1610 1620 1630 1640 1650
1660 1670 1680 1690 1700 1710
pF1KE1 ATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 ATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDS
1660 1670 1680 1690 1700 1710
1720 1730 1740 1750 1760 1770
pF1KE1 GKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 GKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLP
1720 1730 1740 1750 1760 1770
1780 1790 1800 1810 1820 1830
pF1KE1 IKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 IKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPP
1780 1790 1800 1810 1820 1830
1840 1850 1860 1870 1880 1890
pF1KE1 PLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 PLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQ
1840 1850 1860 1870 1880 1890
1900 1910 1920 1930 1940 1950
pF1KE1 QAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 QAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKH
1900 1910 1920 1930 1940 1950
1960 1970 1980 1990 2000 2010
pF1KE1 PGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 PGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTL
1960 1970 1980 1990 2000 2010
2020 2030 2040 2050 2060 2070
pF1KE1 ANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 ANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCK
2020 2030 2040 2050 2060 2070
2080 2090 2100 2110 2120 2130
pF1KE1 LSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 LSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARA
2080 2090 2100 2110 2120 2130
2140 2150 2160 2170 2180 2190
pF1KE1 IAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 IAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARV
2140 2150 2160 2170 2180 2190
2200 2210 2220 2230
pF1KE1 DENRSEFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL
:::::::::::::::::::::::::::::::::::::::::
NP_059 DENRSEFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL
2200 2210 2220 2230
2231 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 20:00:59 2016 done: Sun Nov 6 20:01:02 2016
Total Scan time: 20.610 Total Display time: 1.800
Function used was FASTA [36.3.4 Apr, 2011]