Result of FASTA (omim) for
pFN21AE1590
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1590, 1168 aa
1>>>pF1KE1590 1168 - 1168 aa - 1168 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.6585+/-0.000387; mu= 12.5575+/- 0.024
mean_var=160.2731+/-33.378, 0's: 0 Z-trim(117.7): 206 B-trim: 1401 in 1/53
Lambda= 0.101308
statistics sampled from 29748 (29972) to 29748 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.692), E-opt: 0.2 (0.351), width: 16
Scan time: 16.860
The best scores are: opt bits E(85289)
NP_055988 (OMIM: 609850) TBC1 domain family member (1168) 7754 1146.3 0
XP_016863410 (OMIM: 609850) PREDICTED: TBC1 domain (1039) 6804 1007.4 0
XP_011511968 (OMIM: 609850) PREDICTED: TBC1 domain (1188) 5801 860.8 0
XP_016863409 (OMIM: 609850) PREDICTED: TBC1 domain (1181) 4567 680.5 1.7e-194
XP_016863408 (OMIM: 609850) PREDICTED: TBC1 domain (1222) 4243 633.1 3.1e-180
NP_001240841 (OMIM: 609850) TBC1 domain family mem (1159) 4238 632.4 4.9e-180
XP_005262704 (OMIM: 609850) PREDICTED: TBC1 domain (1262) 4238 632.4 5.3e-180
XP_005262703 (OMIM: 609850) PREDICTED: TBC1 domain (1275) 4238 632.4 5.3e-180
XP_006714064 (OMIM: 609850) PREDICTED: TBC1 domain ( 546) 3612 540.7 9.6e-153
XP_011511965 (OMIM: 609850) PREDICTED: TBC1 domain (1242) 3568 534.5 1.6e-150
XP_016863407 (OMIM: 609850) PREDICTED: TBC1 domain (1228) 3517 527.0 2.7e-148
XP_011511962 (OMIM: 609850) PREDICTED: TBC1 domain (1282) 3517 527.0 2.8e-148
XP_005262706 (OMIM: 609850) PREDICTED: TBC1 domain (1146) 3288 493.5 3.1e-138
XP_011511961 (OMIM: 609850) PREDICTED: TBC1 domain (1295) 3212 482.5 7.5e-135
XP_011511967 (OMIM: 609850) PREDICTED: TBC1 domain (1201) 3205 481.4 1.4e-134
XP_011511966 (OMIM: 609850) PREDICTED: TBC1 domain (1241) 3205 481.4 1.5e-134
XP_011511964 (OMIM: 609850) PREDICTED: TBC1 domain (1255) 3205 481.4 1.5e-134
XP_011511972 (OMIM: 609850) PREDICTED: TBC1 domain ( 494) 3193 479.4 2.4e-134
XP_016876371 (OMIM: 612465,616087) PREDICTED: TBC1 (1054) 2315 351.3 1.9e-95
NP_001273588 (OMIM: 612465,616087) TBC1 domain fam (1235) 2315 351.4 2.1e-95
XP_016876372 (OMIM: 612465,616087) PREDICTED: TBC1 (1017) 2290 347.6 2.3e-94
XP_011511970 (OMIM: 609850) PREDICTED: TBC1 domain ( 812) 2285 346.8 3.2e-94
XP_016863411 (OMIM: 609850) PREDICTED: TBC1 domain ( 939) 2285 346.9 3.6e-94
XP_005266662 (OMIM: 612465,616087) PREDICTED: TBC1 (1117) 2179 331.4 1.9e-89
XP_006719966 (OMIM: 612465,616087) PREDICTED: TBC1 (1140) 2179 331.4 1.9e-89
XP_011533633 (OMIM: 612465,616087) PREDICTED: TBC1 (1261) 2179 331.5 2.1e-89
XP_005266660 (OMIM: 612465,616087) PREDICTED: TBC1 (1273) 2179 331.5 2.1e-89
NP_055647 (OMIM: 612465,616087) TBC1 domain family (1298) 2179 331.5 2.1e-89
NP_001273587 (OMIM: 612465,616087) TBC1 domain fam (1290) 2175 330.9 3.1e-89
XP_016876373 (OMIM: 612465,616087) PREDICTED: TBC1 ( 487) 2026 308.8 5.3e-83
NP_001240843 (OMIM: 609850) TBC1 domain family mem ( 265) 1701 261.1 6.6e-69
NP_001240842 (OMIM: 609850) TBC1 domain family mem ( 265) 1701 261.1 6.6e-69
NP_001240844 (OMIM: 609850) TBC1 domain family mem ( 180) 1118 175.8 2.2e-43
XP_011516744 (OMIM: 615882) PREDICTED: rab GTPase- ( 900) 732 119.9 7.3e-26
XP_016870059 (OMIM: 615882) PREDICTED: rab GTPase- ( 900) 732 119.9 7.3e-26
XP_016870058 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 732 119.9 8.4e-26
XP_016870056 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 732 119.9 8.4e-26
XP_016870057 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 732 119.9 8.4e-26
XP_011516742 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 732 119.9 8.4e-26
NP_036329 (OMIM: 615882) rab GTPase-activating pro (1069) 732 119.9 8.4e-26
XP_011516743 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 732 119.9 8.4e-26
XP_006711756 (OMIM: 609238) PREDICTED: rab GTPase- ( 985) 681 112.5 1.4e-23
XP_005245738 (OMIM: 609238) PREDICTED: rab GTPase- (1014) 681 112.5 1.4e-23
XP_005245737 (OMIM: 609238) PREDICTED: rab GTPase- (1051) 681 112.5 1.4e-23
XP_011508525 (OMIM: 609238) PREDICTED: rab GTPase- (1051) 681 112.5 1.4e-23
XP_016858483 (OMIM: 609238) PREDICTED: rab GTPase- ( 778) 629 104.8 2.2e-21
NP_055672 (OMIM: 609238) rab GTPase-activating pro ( 815) 629 104.8 2.3e-21
XP_016857771 (OMIM: 602942) PREDICTED: ecotropic v ( 812) 593 99.5 8.8e-20
XP_016857761 (OMIM: 602942) PREDICTED: ecotropic v ( 897) 593 99.6 9.5e-20
XP_016857759 (OMIM: 602942) PREDICTED: ecotropic v ( 927) 593 99.6 9.8e-20
>>NP_055988 (OMIM: 609850) TBC1 domain family member 1 i (1168 aa)
initn: 7754 init1: 7754 opt: 7754 Z-score: 6130.4 bits: 1146.3 E(85289): 0
Smith-Waterman score: 7754; 99.9% identity (99.9% similar) in 1168 aa overlap (1-1168:1-1168)
10 20 30 40 50 60
pF1KE1 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPGRRPMRKSFSQPG
::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
NP_055 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPVRRPMRKSFSQPG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERKDFESKANHLGDSGGTPVKTRRHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERKDFESKANHLGDSGGTPVKTRRHS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 WRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSREL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 WRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSREL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 RELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLST
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 PGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQ
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE1 LTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGIL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE1 LLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEI
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE1 GPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE1 TIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRM
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE1 DKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELERSALL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELERSALL
1090 1100 1110 1120 1130 1140
1150 1160
pF1KE1 QTVEELRRRSAEPSDREPECTQPEPTGD
::::::::::::::::::::::::::::
NP_055 QTVEELRRRSAEPSDREPECTQPEPTGD
1150 1160
>>XP_016863410 (OMIM: 609850) PREDICTED: TBC1 domain fam (1039 aa)
initn: 6804 init1: 6804 opt: 6804 Z-score: 5380.7 bits: 1007.4 E(85289): 0
Smith-Waterman score: 6804; 99.9% identity (99.9% similar) in 1030 aa overlap (139-1168:10-1039)
110 120 130 140 150 160
pF1KE1 HDPSYFACLIKEDAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDT
::::::::::::::::::::::::::::::
XP_016 MSPLFSWVAKVPEIISSIRQAGKIARQEELHCPSEFDDT
10 20 30
170 180 190 200 210 220
pF1KE1 FSKKFEVLFCGRVTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPG
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSKKFEVLFCGRVTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPV
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE1 RRPMRKSFSQPGLRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRPMRKSFSQPGLRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEEN
100 110 120 130 140 150
290 300 310 320 330 340
pF1KE1 RTMLFTIGQSEVYLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTMLFTIGQSEVYLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFV
160 170 180 190 200 210
350 360 370 380 390 400
pF1KE1 CYVFQCTNEALVDEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CYVFQCTNEALVDEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSS
220 230 240 250 260 270
410 420 430 440 450 460
pF1KE1 KTKLELQKHLTTLTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTKLELQKHLTTLTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGE
280 290 300 310 320 330
470 480 490 500 510 520
pF1KE1 MKQTSQMAAENIGSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKQTSQMAAENIGSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISV
340 350 360 370 380 390
530 540 550 560 570 580
pF1KE1 DLDSSLSSTLSNTSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLDSSLSSTLSNTSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQ
400 410 420 430 440 450
590 600 610 620 630 640
pF1KE1 AFRRRANTLSHFPIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERKDFESKANHLGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFRRRANTLSHFPIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERKDFESKANHLGD
460 470 480 490 500 510
650 660 670 680 690 700
pF1KE1 SGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPFGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPFGP
520 530 540 550 560 570
710 720 730 740 750 760
pF1KE1 PPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLK
580 590 600 610 620 630
770 780 790 800 810 820
pF1KE1 EVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQ
640 650 660 670 680 690
830 840 850 860 870 880
pF1KE1 PKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVG
700 710 720 730 740 750
890 900 910 920 930 940
pF1KE1 YCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYH
760 770 780 790 800 810
950 960 970 980 990 1000
pF1KE1 RDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGS
820 830 840 850 860 870
1010 1020 1030 1040 1050 1060
pF1KE1 HKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEEL
880 890 900 910 920 930
1070 1080 1090 1100 1110 1120
pF1KE1 IDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQA
940 950 960 970 980 990
1130 1140 1150 1160
pF1KE1 MLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPTGD
::::::::::::::::::::::::::::::::::::::::
XP_016 MLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPTGD
1000 1010 1020 1030
>>XP_011511968 (OMIM: 609850) PREDICTED: TBC1 domain fam (1188 aa)
initn: 5764 init1: 5764 opt: 5801 Z-score: 4587.6 bits: 860.8 E(85289): 0
Smith-Waterman score: 7704; 98.2% identity (98.2% similar) in 1188 aa overlap (1-1168:1-1188)
10 20 30 40 50 60
pF1KE1 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPGRRPMRKSFSQPG
::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
XP_011 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPVRRPMRKSFSQPG
190 200 210 220 230 240
250 260 270 280 290
pF1KE1 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFT------
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTKDKSKR
250 260 270 280 290 300
300 310 320 330 340
pF1KE1 --------------IGQSEVYLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESS
::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPATLCWLKYSSETIGQSEVYLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESS
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE1 GGGGFHFVCYVFQCTNEALVDEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGGGFHFVCYVFQCTNEALVDEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCE
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE1 RIEGMNSSKTKLELQKHLTTLTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RIEGMNSSKTKLELQKHLTTLTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQ
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE1 KEHIHIGEMKQTSQMAAENIGSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEHIHIGEMKQTSQMAAENIGSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARG
490 500 510 520 530 540
530 540 550 560 570 580
pF1KE1 LQEHSISVDLDSSLSSTLSNTSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQEHSISVDLDSSLSSTLSNTSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEE
550 560 570 580 590 600
590 600 610 620 630 640
pF1KE1 PAPLSPQQAFRRRANTLSHFPIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERKDFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PAPLSPQQAFRRRANTLSHFPIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERKDFE
610 620 630 640 650 660
650 660 670 680 690 700
pF1KE1 SKANHLGDSGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKANHLGDSGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPV
670 680 690 700 710 720
710 720 730 740 750 760
pF1KE1 CEDGPFGPPPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CEDGPFGPPPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDY
730 740 750 760 770 780
770 780 790 800 810 820
pF1KE1 EEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLK
790 800 810 820 830 840
830 840 850 860 870 880
pF1KE1 HQFPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HQFPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAY
850 860 870 880 890 900
890 900 910 920 930 940
pF1KE1 SLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQL
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KE1 SRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFK
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KE1 VALSLLGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VALSLLGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVE
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KE1 YHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLS
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160
pF1KE1 SESKLKQAMLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPTGD
::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SESKLKQAMLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPTGD
1150 1160 1170 1180
>>XP_016863409 (OMIM: 609850) PREDICTED: TBC1 domain fam (1181 aa)
initn: 4564 init1: 4564 opt: 4567 Z-score: 3612.9 bits: 680.5 E(85289): 1.7e-194
Smith-Waterman score: 7718; 98.8% identity (98.8% similar) in 1181 aa overlap (1-1168:1-1181)
10 20 30 40 50 60
pF1KE1 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPGRRPMRKSFSQPG
::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
XP_016 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPVRRPMRKSFSQPG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERKDFESKANHLGDSGGTPVKTRRHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERKDFESKANHLGDSGGTPVKTRRHS
610 620 630 640 650 660
670 680 690 700
pF1KE1 WRQQIFLRVATPQKACDSSSRYE-------------DYSELGELPPRSPLEPVCEDGPFG
::::::::::::::::::::::: ::::::::::::::::::::::::
XP_016 WRQQIFLRVATPQKACDSSSRYEEPHCGSPSLACTEDYSELGELPPRSPLEPVCEDGPFG
670 680 690 700 710 720
710 720 730 740 750 760
pF1KE1 PPPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCL
730 740 750 760 770 780
770 780 790 800 810 820
pF1KE1 KEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQ
790 800 810 820 830 840
830 840 850 860 870 880
pF1KE1 QPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEV
850 860 870 880 890 900
890 900 910 920 930 940
pF1KE1 GYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDY
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KE1 HRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLG
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KE1 SHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEE
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KE1 LIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQ
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160
pF1KE1 AMLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPTGD
:::::::::::::::::::::::::::::::::::::::::
XP_016 AMLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPTGD
1150 1160 1170 1180
>>XP_016863408 (OMIM: 609850) PREDICTED: TBC1 domain fam (1222 aa)
initn: 4238 init1: 4238 opt: 4243 Z-score: 3356.8 bits: 633.1 E(85289): 3.1e-180
Smith-Waterman score: 7472; 95.3% identity (95.4% similar) in 1200 aa overlap (1-1146:1-1200)
10 20 30 40 50 60
pF1KE1 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPGRRPMRKSFSQPG
::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
XP_016 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPVRRPMRKSFSQPG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF
550 560 570 580 590 600
610 620 630
pF1KE1 PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHER------------------------
::::::::::::::::::::::::::::::::::::
XP_016 PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERNVDPSPVGESKHRPGQSSAPAPPP
610 620 630 640 650 660
640 650 660
pF1KE1 ------------------------------KDFESKANHLGDSGGTPVKTRRHSWRQQIF
.:::::::::::::::::::::::::::::
XP_016 RLNPSASSPNFFKYLKHNSSGEQSGNAVPKRDFESKANHLGDSGGTPVKTRRHSWRQQIF
670 680 690 700 710 720
670 680 690 700 710 720
pF1KE1 LRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQK
730 740 750 760 770 780
730 740 750 760 770 780
pF1KE1 AILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKI
790 800 810 820 830 840
790 800 810 820 830 840
pF1KE1 KFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQH
850 860 870 880 890 900
850 860 870 880 890 900
pF1KE1 AILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSE
910 920 930 940 950 960
910 920 930 940 950 960
pF1KE1 EEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYA
970 980 990 1000 1010 1020
970 980 990 1000 1010 1020
pF1KE1 APWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFI
1030 1040 1050 1060 1070 1080
1030 1040 1050 1060 1070 1080
pF1KE1 KSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKT
1090 1100 1110 1120 1130 1140
1090 1100 1110 1120 1130 1140
pF1KE1 NSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELERSALLQTVEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELERSALLQTVEEL
1150 1160 1170 1180 1190 1200
1150 1160
pF1KE1 RRRSAEPSDREPECTQPEPTGD
XP_016 RRRSAEPSDREPECTQPEPTGD
1210 1220
>>NP_001240841 (OMIM: 609850) TBC1 domain family member (1159 aa)
initn: 6242 init1: 4238 opt: 4238 Z-score: 3353.1 bits: 632.4 E(85289): 4.9e-180
Smith-Waterman score: 6655; 84.2% identity (84.3% similar) in 1262 aa overlap (1-1168:1-1159)
10 20 30 40 50 60
pF1KE1 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPGRRPMRKSFSQPG
::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
NP_001 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPVRRPMRKSFSQPG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF
550 560 570 580 590 600
610 620 630
pF1KE1 PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHER------------------------
::::::::::::::::::::::::::::::::::::
NP_001 PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERNVDPSPVGESKHRPGQSSAPAPPP
610 620 630 640 650 660
pF1KE1 ------------------------------------------------------------
NP_001 RLNPSASSPNFFKYLKHNSSGEQSGNAVPKSISYRNALRKKLHSSSSVPNFLKFLAPVDE
670 680 690 700 710 720
640 650 660 670 680
pF1KE1 ----------KDFESKANHLGDSGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYEDYS
.:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NNTSDFMNTKRDFESKANHLGDSGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYEDYS
730 740 750 760 770 780
690 700 710 720 730 740
pF1KE1 ELGELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELGELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQA
790 800 810 820 830 840
750 760 770 780 790 800
pF1KE1 SENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHR
850 860 870 880 890 900
810 820 830 840 850 860
pF1KE1 GEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQL
910 920 930 940 950 960
870 880 890 900 910 920
pF1KE1 GAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQY
970 980 990 1000 1010 1020
930 940 950 960 970 980
pF1KE1 RPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARV
::::::::
NP_001 RPDMIILQ----------------------------------------------------
990 1000 1010 1020 1030 1040
pF1KE1 FDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVF
:::::::::
NP_001 ---------------------------------------------------MEKTINQVF
1030
1050 1060 1070 1080 1090 1100
pF1KE1 EMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANG
1040 1050 1060 1070 1080 1090
1110 1120 1130 1140 1150 1160
pF1KE1 RIQSLEATIEKLLSSESKLKQAMLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RIQSLEATIEKLLSSESKLKQAMLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPT
1100 1110 1120 1130 1140 1150
pF1KE1 GD
::
NP_001 GD
>>XP_005262704 (OMIM: 609850) PREDICTED: TBC1 domain fam (1262 aa)
initn: 4238 init1: 4238 opt: 4238 Z-score: 3352.6 bits: 632.4 E(85289): 5.3e-180
Smith-Waterman score: 7170; 92.0% identity (92.1% similar) in 1200 aa overlap (1-1106:1-1200)
10 20 30 40 50 60
pF1KE1 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPGRRPMRKSFSQPG
::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
XP_005 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPVRRPMRKSFSQPG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF
550 560 570 580 590 600
610 620 630
pF1KE1 PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHER------------------------
::::::::::::::::::::::::::::::::::::
XP_005 PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERNVDPSPVGESKHRPGQSSAPAPPP
610 620 630 640 650 660
pF1KE1 ------------------------------------------------------------
XP_005 RLNPSASSPNFFKYLKHNSSGEQSGNAVPKSISYRNALRKKLHSSSSVPNFLKFLAPVDE
670 680 690 700 710 720
640 650 660 670 680
pF1KE1 ----------KDFESKANHLGDSGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYEDYS
.:::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NNTSDFMNTKRDFESKANHLGDSGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYEDYS
730 740 750 760 770 780
690 700 710 720 730 740
pF1KE1 ELGELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELGELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQA
790 800 810 820 830 840
750 760 770 780 790 800
pF1KE1 SENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHR
850 860 870 880 890 900
810 820 830 840 850 860
pF1KE1 GEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQL
910 920 930 940 950 960
870 880 890 900 910 920
pF1KE1 GAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQY
970 980 990 1000 1010 1020
930 940 950 960 970 980
pF1KE1 RPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARV
1030 1040 1050 1060 1070 1080
990 1000 1010 1020 1030 1040
pF1KE1 FDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVF
1090 1100 1110 1120 1130 1140
1050 1060 1070 1080 1090 1100
pF1KE1 EMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANG
1150 1160 1170 1180 1190 1200
1110 1120 1130 1140 1150 1160
pF1KE1 RIQSLEATIEKLLSSESKLKQAMLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPT
XP_005 RIQSLEATIEKLLSSESKLKQAMLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPT
1210 1220 1230 1240 1250 1260
>--
initn: 383 init1: 383 opt: 383 Z-score: 307.6 bits: 69.0 E(85289): 2.2e-10
Smith-Waterman score: 383; 100.0% identity (100.0% similar) in 62 aa overlap (1107-1168:1201-1262)
1080 1090 1100 1110 1120 1130
pF1KE1 NQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELER
::::::::::::::::::::::::::::::
XP_005 NQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELER
1180 1190 1200 1210 1220 1230
1140 1150 1160
pF1KE1 SALLQTVEELRRRSAEPSDREPECTQPEPTGD
::::::::::::::::::::::::::::::::
XP_005 SALLQTVEELRRRSAEPSDREPECTQPEPTGD
1240 1250 1260
>>XP_005262703 (OMIM: 609850) PREDICTED: TBC1 domain fam (1275 aa)
initn: 7422 init1: 4238 opt: 4238 Z-score: 3352.6 bits: 632.4 E(85289): 5.3e-180
Smith-Waterman score: 7054; 90.9% identity (91.0% similar) in 1200 aa overlap (1-1093:1-1200)
10 20 30 40 50 60
pF1KE1 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPGRRPMRKSFSQPG
::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
XP_005 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPVRRPMRKSFSQPG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF
550 560 570 580 590 600
610 620 630
pF1KE1 PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHER------------------------
::::::::::::::::::::::::::::::::::::
XP_005 PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERNVDPSPVGESKHRPGQSSAPAPPP
610 620 630 640 650 660
pF1KE1 ------------------------------------------------------------
XP_005 RLNPSASSPNFFKYLKHNSSGEQSGNAVPKSISYRNALRKKLHSSSSVPNFLKFLAPVDE
670 680 690 700 710 720
640 650 660 670 680
pF1KE1 ----------KDFESKANHLGDSGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYE---
.::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NNTSDFMNTKRDFESKANHLGDSGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYEEPH
730 740 750 760 770 780
690 700 710 720 730
pF1KE1 ----------DYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQKAILQQIL
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CGSPSLACTEDYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQKAILQQIL
790 800 810 820 830 840
740 750 760 770 780 790
pF1KE1 LLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKM
850 860 870 880 890 900
800 810 820 830 840 850
pF1KE1 HSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHAILIDLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHAILIDLG
910 920 930 940 950 960
860 870 880 890 900 910
pF1KE1 RTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKML
970 980 990 1000 1010 1020
920 930 940 950 960 970
pF1KE1 KFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTM
1030 1040 1050 1060 1070 1080
980 990 1000 1010 1020 1030
pF1KE1 FASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTLPNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTLPNL
1090 1100 1110 1120 1130 1140
1040 1050 1060 1070 1080 1090
pF1KE1 GLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQ
1150 1160 1170 1180 1190 1200
1100 1110 1120 1130 1140 1150
pF1KE1 NLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELERSALLQTVEELRRRSAEP
XP_005 NLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELERSALLQTVEELRRRSAEP
1210 1220 1230 1240 1250 1260
>--
initn: 463 init1: 463 opt: 463 Z-score: 370.7 bits: 80.7 E(85289): 6.6e-14
Smith-Waterman score: 463; 100.0% identity (100.0% similar) in 75 aa overlap (1094-1168:1201-1275)
1070 1080 1090 1100 1110 1120
pF1KE1 LQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSES
::::::::::::::::::::::::::::::
XP_005 LQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSES
1180 1190 1200 1210 1220 1230
1130 1140 1150 1160
pF1KE1 KLKQAMLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPTGD
:::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLKQAMLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPTGD
1240 1250 1260 1270
>>XP_006714064 (OMIM: 609850) PREDICTED: TBC1 domain fam (546 aa)
initn: 3612 init1: 3612 opt: 3612 Z-score: 2863.2 bits: 540.7 E(85289): 9.6e-153
Smith-Waterman score: 3612; 100.0% identity (100.0% similar) in 546 aa overlap (623-1168:1-546)
600 610 620 630 640 650
pF1KE1 RANTLSHFPIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERKDFESKANHLGDSGGT
::::::::::::::::::::::::::::::
XP_006 MRYHSVSTETPHERKDFESKANHLGDSGGT
10 20 30
660 670 680 690 700 710
pF1KE1 PVKTRRHSWRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPFGPPPEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PVKTRRHSWRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPFGPPPEE
40 50 60 70 80 90
720 730 740 750 760 770
pF1KE1 KKRTSRELRELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KKRTSRELRELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTT
100 110 120 130 140 150
780 790 800 810 820 830
pF1KE1 VWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDV
160 170 180 190 200 210
840 850 860 870 880 890
pF1KE1 PYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQG
220 230 240 250 260 270
900 910 920 930 940 950
pF1KE1 LSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLY
280 290 300 310 320 330
960 970 980 990 1000 1010
pF1KE1 NHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPL
340 350 360 370 380 390
1020 1030 1040 1050 1060 1070
pF1KE1 ILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSS
400 410 420 430 440 450
1080 1090 1100 1110 1120 1130
pF1KE1 PLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTL
460 470 480 490 500 510
1140 1150 1160
pF1KE1 ELERSALLQTVEELRRRSAEPSDREPECTQPEPTGD
::::::::::::::::::::::::::::::::::::
XP_006 ELERSALLQTVEELRRRSAEPSDREPECTQPEPTGD
520 530 540
>>XP_011511965 (OMIM: 609850) PREDICTED: TBC1 domain fam (1242 aa)
initn: 5501 init1: 3516 opt: 3568 Z-score: 2823.5 bits: 534.5 E(85289): 1.6e-150
Smith-Waterman score: 7303; 93.7% identity (93.8% similar) in 1200 aa overlap (43-1168:43-1242)
20 30 40 50 60 70
pF1KE1 LSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPVTKQVRLCVSPSG
::::::::::::::::::::::::::::::
XP_011 LSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPVTKQVRLCVSPSG
20 30 40 50 60 70
80 90 100 110 120 130
pF1KE1 LRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKEDAVHRQSICYVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKEDAVHRQSICYVF
80 90 100 110 120 130
140 150 160 170 180 190
pF1KE1 KADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGRVTVAHKKAPPAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGRVTVAHKKAPPAL
140 150 160 170 180 190
200 210 220 230 240 250
pF1KE1 IDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPGRRPMRKSFSQPGLRSLAFRKELQD
::::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::
XP_011 IDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPVRRPMRKSFSQPGLRSLAFRKELQD
200 210 220 230 240 250
260 270 280 290
pF1KE1 GGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFT------------------
::::::::::::::::::::::::::::::::::::::::::
XP_011 GGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTKDKSKRLPATLCWLKYSS
260 270 280 290 300 310
300 310 320 330 340 350
pF1KE1 --IGQSEVYLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETIGQSEVYLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVF
320 330 340 350 360 370
360 370 380 390 400 410
pF1KE1 QCTNEALVDEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QCTNEALVDEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKL
380 390 400 410 420 430
420 430 440 450 460 470
pF1KE1 ELQKHLTTLTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELQKHLTTLTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQT
440 450 460 470 480 490
480 490 500 510 520 530
pF1KE1 SQMAAENIGSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQMAAENIGSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDS
500 510 520 530 540 550
540 550 560 570 580 590
pF1KE1 SLSSTLSNTSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLSSTLSNTSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRR
560 570 580 590 600 610
600 610 620 630
pF1KE1 RANTLSHFPIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHER----------------
::::::::::::::::::::::::::::::::::::::::::::
XP_011 RANTLSHFPIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERNVDPSPVGESKHRPGQ
620 630 640 650 660 670
640 650
pF1KE1 --------------------------------------KDFESKANHLGDSGGTPVKTRR
.:::::::::::::::::::::
XP_011 SSAPAPPPRLNPSASSPNFFKYLKHNSSGEQSGNAVPKRDFESKANHLGDSGGTPVKTRR
680 690 700 710 720 730
660 670 680 690 700 710
pF1KE1 HSWRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSWRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSR
740 750 760 770 780 790
720 730 740 750 760 770
pF1KE1 ELRELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELRELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKML
800 810 820 830 840 850
780 790 800 810 820 830
pF1KE1 STPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELL
860 870 880 890 900 910
840 850 860 870 880 890
pF1KE1 KQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAG
920 930 940 950 960 970
900 910 920 930 940 950
pF1KE1 ILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEH
980 990 1000 1010 1020 1030
960 970 980 990 1000 1010
pF1KE1 EIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHEN
1040 1050 1060 1070 1080 1090
1020 1030 1040 1050 1060 1070
pF1KE1 LETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQ
1100 1110 1120 1130 1140 1150
1080 1090 1100 1110 1120 1130
pF1KE1 RMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELERSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELERSA
1160 1170 1180 1190 1200 1210
1140 1150 1160
pF1KE1 LLQTVEELRRRSAEPSDREPECTQPEPTGD
::::::::::::::::::::::::::::::
XP_011 LLQTVEELRRRSAEPSDREPECTQPEPTGD
1220 1230 1240
>--
initn: 280 init1: 280 opt: 280 Z-score: 226.3 bits: 53.9 E(85289): 7.2e-06
Smith-Waterman score: 280; 100.0% identity (100.0% similar) in 42 aa overlap (1-42:1-42)
10 20 30 40 50 60
pF1KE1 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
::::::::::::::::::::::::::::::::::::::::::
XP_011 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
XP_011 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
70 80 90 100 110 120
1168 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 19:35:23 2016 done: Sat Nov 5 19:35:25 2016
Total Scan time: 16.860 Total Display time: 0.520
Function used was FASTA [36.3.4 Apr, 2011]