FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6729, 1085 aa 1>>>pF1KE6729 1085 - 1085 aa - 1085 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1136+/-0.000461; mu= 23.0063+/- 0.028 mean_var=74.1782+/-15.815, 0's: 0 Z-trim(109.4): 71 B-trim: 808 in 1/52 Lambda= 0.148914 statistics sampled from 17497 (17568) to 17497 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.539), E-opt: 0.2 (0.206), width: 16 Scan time: 10.530 The best scores are: opt bits E(85289) NP_005063 (OMIM: 604119) solute carrier family 12 (1085) 7215 1560.7 0 NP_001139433 (OMIM: 604119) solute carrier family (1079) 7159 1548.7 0 NP_001139435 (OMIM: 604119) solute carrier family (1079) 6952 1504.2 0 NP_001139436 (OMIM: 604119) solute carrier family (1054) 6944 1502.5 0 NP_001139434 (OMIM: 604119) solute carrier family (1087) 6720 1454.4 0 NP_001035960 (OMIM: 218000,604878) solute carrier (1091) 5563 1205.8 0 NP_001035959 (OMIM: 218000,604878) solute carrier (1091) 5563 1205.8 0 NP_001035961 (OMIM: 218000,604878) solute carrier (1141) 5563 1205.8 0 NP_598408 (OMIM: 218000,604878) solute carrier fam (1150) 5563 1205.8 0 NP_005126 (OMIM: 218000,604878) solute carrier fam (1099) 5556 1204.3 0 NP_001035962 (OMIM: 218000,604878) solute carrier (1135) 5544 1201.7 0 NP_006589 (OMIM: 604879) solute carrier family 12 (1083) 5057 1097.1 0 XP_005248288 (OMIM: 604879) PREDICTED: solute carr (1088) 5037 1092.8 0 XP_011512241 (OMIM: 604879) PREDICTED: solute carr (1085) 5011 1087.2 0 XP_011512243 (OMIM: 604879) PREDICTED: solute carr (1111) 5011 1087.2 0 XP_011512242 (OMIM: 604879) PREDICTED: solute carr (1074) 5005 1085.9 0 XP_006720856 (OMIM: 218000,604878) PREDICTED: solu (1101) 4975 1079.5 0 XP_016864448 (OMIM: 604879) PREDICTED: solute carr (1020) 4943 1072.6 0 XP_016864447 (OMIM: 604879) PREDICTED: solute carr (1020) 4943 1072.6 0 XP_016883470 (OMIM: 606726,616645,616685) PREDICTE (1134) 4642 1008.0 0 NP_001128243 (OMIM: 606726,616645,616685) solute c (1139) 4642 1008.0 0 NP_065759 (OMIM: 606726,616645,616685) solute carr (1116) 4627 1004.7 0 XP_011520571 (OMIM: 218000,604878) PREDICTED: solu ( 680) 2929 639.8 1.6e-182 XP_005250559 (OMIM: 616861) PREDICTED: solute carr ( 825) 673 155.1 1.5e-36 XP_006716117 (OMIM: 616861) PREDICTED: solute carr ( 825) 673 155.1 1.5e-36 XP_011514716 (OMIM: 616861) PREDICTED: solute carr ( 722) 665 153.4 4.5e-36 NP_001243390 (OMIM: 600840) solute carrier family (1196) 628 145.6 1.6e-33 XP_016865260 (OMIM: 600840) PREDICTED: solute carr ( 626) 624 144.5 1.8e-33 NP_001254743 (OMIM: 616861) solute carrier family ( 538) 613 142.1 8.3e-33 XP_005254663 (OMIM: 600839,601678) PREDICTED: solu (1099) 583 135.9 1.2e-30 NP_001119579 (OMIM: 263800,600968) solute carrier (1029) 577 134.6 2.9e-30 NP_000330 (OMIM: 263800,600968) solute carrier fam (1030) 577 134.6 2.9e-30 XP_005256176 (OMIM: 263800,600968) PREDICTED: solu (1020) 545 127.7 3.4e-28 NP_001119580 (OMIM: 263800,600968) solute carrier (1021) 545 127.7 3.4e-28 XP_005250561 (OMIM: 616861) PREDICTED: solute carr ( 556) 499 117.6 2e-25 XP_011541890 (OMIM: 600840) PREDICTED: solute carr ( 628) 405 97.5 2.6e-19 NP_001037 (OMIM: 600840) solute carrier family 12 (1212) 405 97.7 4.3e-19 NP_001171761 (OMIM: 600839,601678) solute carrier (1099) 389 94.2 4.4e-18 NP_000329 (OMIM: 600839,601678) solute carrier fam (1099) 384 93.2 9.2e-18 NP_001254741 (OMIM: 616861) solute carrier family ( 631) 379 91.9 1.3e-17 NP_064631 (OMIM: 616861) solute carrier family 12 ( 914) 379 92.0 1.7e-17 XP_006716118 (OMIM: 616861) PREDICTED: solute carr ( 811) 367 89.4 9.2e-17 NP_078904 (OMIM: 611316) solute carrier family 12 ( 714) 281 70.9 3e-11 NP_001182412 (OMIM: 611316) solute carrier family ( 714) 281 70.9 3e-11 XP_016869236 (OMIM: 601872) PREDICTED: cationic am ( 657) 182 49.6 7.2e-05 NP_003037 (OMIM: 601872) cationic amino acid trans ( 697) 182 49.6 7.5e-05 NP_001253966 (OMIM: 604235) large neutral amino ac ( 311) 172 47.2 0.00018 XP_005273668 (OMIM: 601872) PREDICTED: cationic am ( 658) 170 47.0 0.00043 XP_016869235 (OMIM: 601872) PREDICTED: cationic am ( 658) 170 47.0 0.00043 XP_005273667 (OMIM: 601872) PREDICTED: cationic am ( 658) 170 47.0 0.00043 >>NP_005063 (OMIM: 604119) solute carrier family 12 memb (1085 aa) initn: 7215 init1: 7215 opt: 7215 Z-score: 8371.3 bits: 1560.7 E(85289): 0 Smith-Waterman score: 7215; 100.0% identity (100.0% similar) in 1085 aa overlap (1-1085:1-1085) 10 20 30 40 50 60 pF1KE6 MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAELDDSDGHGNHRESSPFLSPLEASRGID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAELDDSDGHGNHRESSPFLSPLEASRGID 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 YYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 YYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 LMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 PAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 HDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 HDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 DPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 NVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 TVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 VLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE6 FLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 FLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE6 LLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE6 WGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 WGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKA 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE6 GKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE6 CGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 CGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHER 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE6 YLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 YLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLY 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE6 HLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 HLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSAL 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE6 RLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 RLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMH 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE6 TAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREV 1030 1040 1050 1060 1070 1080 pF1KE6 ITIYS ::::: NP_005 ITIYS >>NP_001139433 (OMIM: 604119) solute carrier family 12 m (1079 aa) initn: 7167 init1: 6058 opt: 7159 Z-score: 8306.3 bits: 1548.7 E(85289): 0 Smith-Waterman score: 7159; 99.4% identity (99.4% similar) in 1085 aa overlap (1-1085:1-1079) 10 20 30 40 50 60 pF1KE6 MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAELDDSDGHGNHRESSPFLSPLEASRGID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAELDDSDGHGNHRESSPFLSPLEASRGID 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 YYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 LMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 PAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 HDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 DPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 NVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 TVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 VLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE6 FLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE6 LLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE6 WGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKA 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE6 GKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE6 CGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHER 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE6 YLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLY 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE6 HLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSAL ::::::: ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLRLEAE------HNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSAL 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KE6 RLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMH 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KE6 TAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREV 1020 1030 1040 1050 1060 1070 pF1KE6 ITIYS ::::: NP_001 ITIYS >>NP_001139435 (OMIM: 604119) solute carrier family 12 m (1079 aa) initn: 6940 init1: 6940 opt: 6952 Z-score: 8066.0 bits: 1504.2 E(85289): 0 Smith-Waterman score: 6952; 98.6% identity (99.0% similar) in 1067 aa overlap (20-1085:13-1079) 10 20 30 40 50 pF1KE6 MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAELDDSD-GHGNHRESSPFLSPLEASRGI ::: .:. . : . ::::::::::::::::::::: NP_001 MAAEGAVCGFVYLEGTAWAVPEDTEPLASCTLGHGNHRESSPFLSPLEASRGI 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 DYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMG 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 TLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGV 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 VPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSG 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE6 AHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSI 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE6 FDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFML 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE6 NNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATS 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE6 FTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEG 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE6 VVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNII 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE6 PFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQ 540 550 560 570 580 590 600 610 620 630 640 650 pF1KE6 TLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEK 600 610 620 630 640 650 660 670 680 690 700 710 pF1KE6 EWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLK 660 670 680 690 700 710 720 730 740 750 760 770 pF1KE6 AGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQ 720 730 740 750 760 770 780 790 800 810 820 830 pF1KE6 SCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHE 780 790 800 810 820 830 840 850 860 870 880 890 pF1KE6 RYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFL 840 850 860 870 880 890 900 910 920 930 940 950 pF1KE6 YHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSA 900 910 920 930 940 950 960 970 980 990 1000 1010 pF1KE6 LRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRM 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 pF1KE6 HTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGRE 1020 1030 1040 1050 1060 1070 1080 pF1KE6 VITIYS :::::: NP_001 VITIYS >>NP_001139436 (OMIM: 604119) solute carrier family 12 m (1054 aa) initn: 6944 init1: 6944 opt: 6944 Z-score: 8056.8 bits: 1502.5 E(85289): 0 Smith-Waterman score: 6944; 99.9% identity (99.9% similar) in 1049 aa overlap (37-1085:6-1054) 10 20 30 40 50 60 pF1KE6 VPVDGPRRGDYDNLEGLSWVDYGERAELDDSDGHGNHRESSPFLSPLEASRGIDYYDRNL : :::::::::::::::::::::::::::: NP_001 MGDTLSPGHGNHRESSPFLSPLEASRGIDYYDRNL 10 20 30 70 80 90 100 110 120 pF1KE6 ALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYL 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE6 PCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSY 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE6 FMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNA 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE6 TLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFP 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE6 VCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIP 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE6 GIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGI 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE6 FFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKY 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE6 GDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFG 460 470 480 490 500 510 550 560 570 580 590 600 pF1KE6 HGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPN 520 530 540 550 560 570 610 620 630 640 650 660 pF1KE6 WRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIR 580 590 600 610 620 630 670 680 690 700 710 720 pF1KE6 GLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTI 640 650 660 670 680 690 730 740 750 760 770 780 pF1KE6 VGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGM 700 710 720 730 740 750 790 800 810 820 830 840 pF1KE6 RHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHI 760 770 780 790 800 810 850 860 870 880 890 900 pF1KE6 DVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEA 820 830 840 850 860 870 910 920 930 940 950 960 pF1KE6 EVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLY 880 890 900 910 920 930 970 980 990 1000 1010 1020 pF1KE6 SDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLN 940 950 960 970 980 990 1030 1040 1050 1060 1070 1080 pF1KE6 EVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1000 1010 1020 1030 1040 1050 >>NP_001139434 (OMIM: 604119) solute carrier family 12 m (1087 aa) initn: 6720 init1: 6720 opt: 6720 Z-score: 7796.6 bits: 1454.4 E(85289): 0 Smith-Waterman score: 6720; 100.0% identity (100.0% similar) in 1015 aa overlap (71-1085:73-1087) 50 60 70 80 90 100 pF1KE6 GNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHE :::::::::::::::::::::::::::::: NP_001 WTGRGAATMTTSRGSVGWTTGSAPSWMTRTEELDIRPKVSSLLGKLVSYTNLTQGAKEHE 50 60 70 80 90 100 110 120 130 140 150 160 pF1KE6 EAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE6 CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGA 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE6 IEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLF 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE6 LACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWS 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE6 FFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSAD 350 360 370 380 390 400 410 420 430 440 450 460 pF1KE6 APSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAII 410 420 430 440 450 460 470 480 490 500 510 520 pF1KE6 TTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGL 470 480 490 500 510 520 530 540 550 560 570 580 pF1KE6 QSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPI 530 540 550 560 570 580 590 600 610 620 630 640 pF1KE6 LSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALV 590 600 610 620 630 640 650 660 670 680 690 700 pF1KE6 AMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKL 650 660 670 680 690 700 710 720 730 740 750 760 pF1KE6 DEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKG 710 720 730 740 750 760 770 780 790 800 810 820 pF1KE6 FCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTA 770 780 790 800 810 820 830 840 850 860 870 880 pF1KE6 AHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFT 830 840 850 860 870 880 890 900 910 920 930 940 pF1KE6 VAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMR 890 900 910 920 930 940 950 960 970 980 990 1000 pF1KE6 LTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAP 950 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 pF1KE6 DNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFL 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE6 EVLTEGLERVLLVRGGGREVITIYS ::::::::::::::::::::::::: NP_001 EVLTEGLERVLLVRGGGREVITIYS 1070 1080 >>NP_001035960 (OMIM: 218000,604878) solute carrier fami (1091 aa) initn: 5528 init1: 3874 opt: 5563 Z-score: 6453.2 bits: 1205.8 E(85289): 0 Smith-Waterman score: 5563; 76.8% identity (91.2% similar) in 1087 aa overlap (4-1085:11-1091) 10 20 30 40 pF1KE6 MPHFTVVPVDGPR-RGDY--DNLEGLSWVDY-GERAELDDSDGHGNHRESSPF ...: .: : : .. : .: :: . ::...: : ::: . :.. . NP_001 MSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLD-DGHKKARNA--Y 10 20 30 40 50 50 60 70 80 90 100 pF1KE6 LSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTR :. . .: .:.:.::::::::.: ::::::::.....:::::::::::::::. . NP_001 LNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGK 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE6 RRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAI .. ...:.:::.::::::::::::::::::::::.:::::::::. :::::::::.:::: NP_001 KKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAI 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE6 SMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIA ::::::::::::::::::::::.:::::::::::::::::::::::::::::::.:.::. NP_001 SMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIV 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE6 PPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISIL : ::::. . : : : ::::::::: ::..:.::::.::.::::::::::::::.::: NP_001 PRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSIL 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE6 SIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLT .::::.::: : :: :::::::::::: ..:.:.:: ..: :: ..::.:::.: .. NP_001 AIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFF 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE6 TDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLP . .:: ::. :::: : :::: :.:.. ::::: :: ::.:.:: ::: . .. :: NP_001 NATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEK---PSAKSSDVLGSLN 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE6 L-YVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFS ::..::.::::.::::::::::::::::::::::.:::::::.::::::.:::.::.: NP_001 HEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLS 420 430 440 450 460 470 470 480 490 500 510 520 pF1KE6 SVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPR .::::::::::::::::.::.:. :::::::.:::::::::::::::::::::::::::: NP_001 NVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPR 480 490 500 510 520 530 530 540 550 560 570 580 pF1KE6 LLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMC :::::::::::::::::::.:.:::::::::::: ::::::::::::.:::::::::::: NP_001 LLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMC 540 550 560 570 580 590 590 600 610 620 630 640 pF1KE6 YLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMI :::::::::.:::::::::::::.::::::::.:::.::::::.::::::.:::.::::: NP_001 YLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMI 600 610 620 630 640 650 650 660 670 680 690 700 pF1KE6 YKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKY ::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::. NP_001 YKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKH 660 670 680 690 700 710 710 720 730 740 750 760 pF1KE6 PRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVAS ::::::::::::::::::::::: :.:::.:::: :::::::..:: ::::::::.:::. NP_001 PRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAA 720 730 740 750 760 770 770 780 790 800 810 820 pF1KE6 KVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVP :.:::..:::::::::::.::.::.::: ::::::: ::::::: ::: :::::::::: NP_001 KLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVA 780 790 800 810 820 830 830 840 850 860 870 880 pF1KE6 KNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNS :::.:.::: :.. ::.::::::::::::::::::::.:::::::: .:::::::..::: NP_001 KNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNS 840 850 860 870 880 890 890 900 910 920 930 940 pF1KE6 IQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTERER ::::::::.::::::.::::::::::.::::::::::::::::::::::.:::.::::.: NP_001 IQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDR 900 910 920 930 940 950 950 960 970 980 990 1000 pF1KE6 EAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVH ::::::::.: ::: :. :::..:. . .:..::::.::::. . ... ..:..:.. NP_001 EAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLN 960 970 980 990 1000 1010 1010 1020 1030 1040 1050 1060 pF1KE6 IKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLE ..::::::::::::::::::::..::.:.:::::::::::: :::::::::::::::::: NP_001 MRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLE 1020 1030 1040 1050 1060 1070 1070 1080 pF1KE6 RVLLVRGGGREVITIYS ::::::::: ::::::: NP_001 RVLLVRGGGSEVITIYS 1080 1090 >>NP_001035959 (OMIM: 218000,604878) solute carrier fami (1091 aa) initn: 5528 init1: 3874 opt: 5563 Z-score: 6453.2 bits: 1205.8 E(85289): 0 Smith-Waterman score: 5563; 76.8% identity (91.2% similar) in 1087 aa overlap (4-1085:11-1091) 10 20 30 40 pF1KE6 MPHFTVVPVDGPR-RGDY--DNLEGLSWVDY-GERAELDDSDGHGNHRESSPF ...: .: : : .. : .: :: . ::...: : ::: . :.. . NP_001 MSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLD-DGHKKARNA--Y 10 20 30 40 50 50 60 70 80 90 100 pF1KE6 LSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTR :. . .: .:.:.::::::::.: ::::::::.....:::::::::::::::. . NP_001 LNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGK 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE6 RRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAI .. ...:.:::.::::::::::::::::::::::.:::::::::. :::::::::.:::: NP_001 KKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAI 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE6 SMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIA ::::::::::::::::::::::.:::::::::::::::::::::::::::::::.:.::. NP_001 SMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIV 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE6 PPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISIL : ::::. . : : : ::::::::: ::..:.::::.::.::::::::::::::.::: NP_001 PRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSIL 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE6 SIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLT .::::.::: : :: :::::::::::: ..:.:.:: ..: :: ..::.:::.: .. NP_001 AIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFF 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE6 TDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLP . .:: ::. :::: : :::: :.:.. ::::: :: ::.:.:: ::: . .. :: NP_001 NATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEK---PSAKSSDVLGSLN 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE6 L-YVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFS ::..::.::::.::::::::::::::::::::::.:::::::.::::::.:::.::.: NP_001 HEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLS 420 430 440 450 460 470 470 480 490 500 510 520 pF1KE6 SVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPR .::::::::::::::::.::.:. :::::::.:::::::::::::::::::::::::::: NP_001 NVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPR 480 490 500 510 520 530 530 540 550 560 570 580 pF1KE6 LLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMC :::::::::::::::::::.:.:::::::::::: ::::::::::::.:::::::::::: NP_001 LLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMC 540 550 560 570 580 590 590 600 610 620 630 640 pF1KE6 YLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMI :::::::::.:::::::::::::.::::::::.:::.::::::.::::::.:::.::::: NP_001 YLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMI 600 610 620 630 640 650 650 660 670 680 690 700 pF1KE6 YKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKY ::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::. NP_001 YKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKH 660 670 680 690 700 710 710 720 730 740 750 760 pF1KE6 PRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVAS ::::::::::::::::::::::: :.:::.:::: :::::::..:: ::::::::.:::. NP_001 PRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAA 720 730 740 750 760 770 770 780 790 800 810 820 pF1KE6 KVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVP :.:::..:::::::::::.::.::.::: ::::::: ::::::: ::: :::::::::: NP_001 KLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVA 780 790 800 810 820 830 830 840 850 860 870 880 pF1KE6 KNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNS :::.:.::: :.. ::.::::::::::::::::::::.:::::::: .:::::::..::: NP_001 KNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNS 840 850 860 870 880 890 890 900 910 920 930 940 pF1KE6 IQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTERER ::::::::.::::::.::::::::::.::::::::::::::::::::::.:::.::::.: NP_001 IQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDR 900 910 920 930 940 950 950 960 970 980 990 1000 pF1KE6 EAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVH ::::::::.: ::: :. :::..:. . .:..::::.::::. . ... ..:..:.. NP_001 EAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLN 960 970 980 990 1000 1010 1010 1020 1030 1040 1050 1060 pF1KE6 IKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLE ..::::::::::::::::::::..::.:.:::::::::::: :::::::::::::::::: NP_001 MRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLE 1020 1030 1040 1050 1060 1070 1070 1080 pF1KE6 RVLLVRGGGREVITIYS ::::::::: ::::::: NP_001 RVLLVRGGGSEVITIYS 1080 1090 >>NP_001035961 (OMIM: 218000,604878) solute carrier fami (1141 aa) initn: 5528 init1: 3874 opt: 5563 Z-score: 6452.9 bits: 1205.8 E(85289): 0 Smith-Waterman score: 5563; 76.8% identity (91.2% similar) in 1087 aa overlap (4-1085:61-1141) 10 20 pF1KE6 MPHFTVVPVDGPR-RGDY--DNLEGLSWVDY-G ...: .: : : .. : .: :: . : NP_001 SSRVRFSSRESVPETSRSEPMSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITG 40 50 60 70 80 90 30 40 50 60 70 80 pF1KE6 ERAELDDSDGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSY :...: : ::: . :.. .:. . .: .:.:.::::::::.: ::::::::.....: NP_001 EHSQLLD-DGHKKARNA--YLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANY 100 110 120 130 140 90 100 110 120 130 140 pF1KE6 TNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAG ::::::::::::::. ... ...:.:::.::::::::::::::::::::::.::::: NP_001 TNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAG 150 160 170 180 190 200 150 160 170 180 190 200 pF1KE6 VLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGT ::::. :::::::::.::::::::::::::::::::::::::.::::::::::::::::: NP_001 VLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGT 210 220 230 240 250 260 210 220 230 240 250 260 pF1KE6 TFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVG ::::::::::::::.:.::.: ::::. . : : : ::::::::: ::..:.::::.: NP_001 TFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIG 270 280 290 300 310 320 270 280 290 300 310 320 pF1KE6 VKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVV :.::::::::::::::.:::.::::.::: : :: :::::::::::: ..:.:.:: . NP_001 VRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEI 330 340 350 360 370 380 330 340 350 360 370 380 pF1KE6 DNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGD .: :: ..::.:::.: .. . .:: ::. :::: : :::: :.:.. ::::: :: ::. NP_001 NNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGE 390 400 410 420 430 440 390 400 410 420 430 440 pF1KE6 IVEKHGLPSADAPSLKESLPL-YVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQ :.:: ::: . .. :: ::..::.::::.::::::::::::::::::::::.::: NP_001 IIEK---PSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQ 450 460 470 480 490 500 450 460 470 480 490 500 pF1KE6 KSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIV ::::.::::::.:::.::.:.::::::::::::::::.::.:. :::::::.:::::::: NP_001 KSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIV 510 520 530 540 550 560 510 520 530 540 550 560 pF1KE6 IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELG :::::::::::::::::::::::::::::::::::::::.:.:::::::::::: ::::: NP_001 IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELG 570 580 590 600 610 620 570 580 590 600 610 620 pF1KE6 ILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLA :::::::.:::::::::::::::::::::.:::::::::::::.::::::::.:::.::: NP_001 ILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLA 630 640 650 660 670 680 630 640 650 660 670 680 pF1KE6 LMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTK :::.::::::.:::.:::::::::::::::::::::::::::::::.::::::::::::: NP_001 LMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTK 690 700 710 720 730 740 690 700 710 720 730 740 pF1KE6 NWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQT :::::::::::::::::::.::::::::::::::::::::::: :.:::.:::: ::::: NP_001 NWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQT 750 760 770 780 790 800 750 760 770 780 790 800 pF1KE6 IKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAW ::..:: ::::::::.:::.:.:::..:::::::::::.::.::.::: ::::::: ::: NP_001 IKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAW 810 820 830 840 850 860 810 820 830 840 850 860 pF1KE6 KTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQH :::: ::: :::::::::: :::.:.::: :.. ::.::::::::::::::::::::.:: NP_001 KTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQH 870 880 890 900 910 920 870 880 890 900 910 920 pF1KE6 KVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLM :::::: .:::::::..:::::::::::.::::::.::::::::::.::::::::::::: NP_001 KVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLM 930 940 950 960 970 980 930 940 950 960 970 980 pF1KE6 MEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDK :::::::::.:::.::::.:::::::::.: ::: :. :::..:. . .:..::::.:: NP_001 MEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDK 990 1000 1010 1020 1030 1040 990 1000 1010 1020 1030 1040 pF1KE6 YMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPR ::. . ... ..:..:....::::::::::::::::::::..::.:.::::::::::: NP_001 YMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPR 1050 1060 1070 1080 1090 1100 1050 1060 1070 1080 pF1KE6 NSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS : ::::::::::::::::::::::::::: ::::::: NP_001 NPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1110 1120 1130 1140 >>NP_598408 (OMIM: 218000,604878) solute carrier family (1150 aa) initn: 5528 init1: 3874 opt: 5563 Z-score: 6452.8 bits: 1205.8 E(85289): 0 Smith-Waterman score: 5563; 76.8% identity (91.2% similar) in 1087 aa overlap (4-1085:70-1150) 10 20 pF1KE6 MPHFTVVPVDGPR-RGDY--DNLEGLSWVDY-G ...: .: : : .. : .: :: . : NP_598 SSRVRFSSRESVPETSRSEPMSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITG 40 50 60 70 80 90 30 40 50 60 70 80 pF1KE6 ERAELDDSDGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSY :...: : ::: . :.. .:. . .: .:.:.::::::::.: ::::::::.....: NP_598 EHSQLLD-DGHKKARNA--YLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANY 100 110 120 130 140 150 90 100 110 120 130 140 pF1KE6 TNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAG ::::::::::::::. ... ...:.:::.::::::::::::::::::::::.::::: NP_598 TNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAG 160 170 180 190 200 210 150 160 170 180 190 200 pF1KE6 VLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGT ::::. :::::::::.::::::::::::::::::::::::::.::::::::::::::::: NP_598 VLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGT 220 230 240 250 260 270 210 220 230 240 250 260 pF1KE6 TFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVG ::::::::::::::.:.::.: ::::. . : : : ::::::::: ::..:.::::.: NP_598 TFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIG 280 290 300 310 320 330 270 280 290 300 310 320 pF1KE6 VKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVV :.::::::::::::::.:::.::::.::: : :: :::::::::::: ..:.:.:: . NP_598 VRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEI 340 350 360 370 380 390 330 340 350 360 370 380 pF1KE6 DNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGD .: :: ..::.:::.: .. . .:: ::. :::: : :::: :.:.. ::::: :: ::. NP_598 NNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGE 400 410 420 430 440 450 390 400 410 420 430 440 pF1KE6 IVEKHGLPSADAPSLKESLPL-YVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQ :.:: ::: . .. :: ::..::.::::.::::::::::::::::::::::.::: NP_598 IIEK---PSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQ 460 470 480 490 500 510 450 460 470 480 490 500 pF1KE6 KSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIV ::::.::::::.:::.::.:.::::::::::::::::.::.:. :::::::.:::::::: NP_598 KSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIV 520 530 540 550 560 570 510 520 530 540 550 560 pF1KE6 IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELG :::::::::::::::::::::::::::::::::::::::.:.:::::::::::: ::::: NP_598 IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELG 580 590 600 610 620 630 570 580 590 600 610 620 pF1KE6 ILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLA :::::::.:::::::::::::::::::::.:::::::::::::.::::::::.:::.::: NP_598 ILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLA 640 650 660 670 680 690 630 640 650 660 670 680 pF1KE6 LMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTK :::.::::::.:::.:::::::::::::::::::::::::::::::.::::::::::::: NP_598 LMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTK 700 710 720 730 740 750 690 700 710 720 730 740 pF1KE6 NWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQT :::::::::::::::::::.::::::::::::::::::::::: :.:::.:::: ::::: NP_598 NWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQT 760 770 780 790 800 810 750 760 770 780 790 800 pF1KE6 IKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAW ::..:: ::::::::.:::.:.:::..:::::::::::.::.::.::: ::::::: ::: NP_598 IKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAW 820 830 840 850 860 870 810 820 830 840 850 860 pF1KE6 KTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQH :::: ::: :::::::::: :::.:.::: :.. ::.::::::::::::::::::::.:: NP_598 KTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQH 880 890 900 910 920 930 870 880 890 900 910 920 pF1KE6 KVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLM :::::: .:::::::..:::::::::::.::::::.::::::::::.::::::::::::: NP_598 KVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLM 940 950 960 970 980 990 930 940 950 960 970 980 pF1KE6 MEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDK :::::::::.:::.::::.:::::::::.: ::: :. :::..:. . .:..::::.:: NP_598 MEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDK 1000 1010 1020 1030 1040 1050 990 1000 1010 1020 1030 1040 pF1KE6 YMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPR ::. . ... ..:..:....::::::::::::::::::::..::.:.::::::::::: NP_598 YMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPR 1060 1070 1080 1090 1100 1110 1050 1060 1070 1080 pF1KE6 NSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS : ::::::::::::::::::::::::::: ::::::: NP_598 NPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1120 1130 1140 1150 >>NP_005126 (OMIM: 218000,604878) solute carrier family (1099 aa) initn: 5582 init1: 3874 opt: 5556 Z-score: 6445.0 bits: 1204.3 E(85289): 0 Smith-Waterman score: 5569; 75.9% identity (89.9% similar) in 1106 aa overlap (1-1085:1-1099) 10 20 30 40 pF1KE6 MPHFTVVPVDGPRRG-------------------DYDNLEGLSWVDY-GERAELDDSDGH ::::::. :. :..: : :. :: . ::...: : ::: NP_005 MPHFTVTKVEDPEEGAAASISQEPSLADIKARIQDSDE-PDLSQNSITGEHSQLLD-DGH 10 20 30 40 50 50 60 70 80 90 100 pF1KE6 GNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHE . :.. .:. . .: .:.:.::::::::.: ::::::::.....:::::::::::: NP_005 KKARNA--YLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHE 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE6 EAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC :::. ... ...:.:::.::::::::::::::::::::::.:::::::::. ::::: NP_005 EAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLIC 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE6 CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGA ::::.::::::::::::::::::::::::::.:::::::::::::::::::::::::::: NP_005 CCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGA 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE6 IEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLF :::.:.::.: ::::. . : : : ::::::::: ::..:.::::.::.::::::::: NP_005 IEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLF 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE6 LACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWS :::::.:::.::::.::: : :: :::::::::::: ..:.:.:: ..: :: ..::. NP_005 LACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWG 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE6 FFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSAD :::.: .. . .:: ::. :::: : :::: :.:.. ::::: :: ::.:.:: ::: NP_005 FFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEK---PSAK 360 370 380 390 400 410 410 420 430 440 450 pF1KE6 APSLKESLPL-YVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAI . .. :: ::..::.::::.::::::::::::::::::::::.:::::::.:::::: NP_005 SSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAI 420 430 440 450 460 470 460 470 480 490 500 510 pF1KE6 ITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAG .:::.::.:.::::::::::::::::.::.:. :::::::.::::::::::::::::::: NP_005 LTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAG 480 490 500 510 520 530 520 530 540 550 560 570 pF1KE6 LQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAP ::::::::::::::::::::::::::::.:.:::::::::::: ::::::::::::.::: NP_005 LQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAP 540 550 560 570 580 590 580 590 600 610 620 630 pF1KE6 ILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYAL ::::::::::::::::::.:::::::::::::.::::::::.:::.::::::.::::::. NP_005 ILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAI 600 610 620 630 640 650 640 650 660 670 680 690 pF1KE6 VAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLK :::.:::::::::::::::::::::::::::::::.:::::::::::::::::::::::: NP_005 VAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLK 660 670 680 690 700 710 700 710 720 730 740 750 pF1KE6 LDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVK ::::::::.::::::::::::::::::::::: :.:::.:::: :::::::..:: :::: NP_005 LDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVK 720 730 740 750 760 770 760 770 780 790 800 810 pF1KE6 GFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTT ::::.:::.:.:::..:::::::::::.::.::.::: ::::::: ::::::: ::: :: NP_005 GFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTT 780 790 800 810 820 830 820 830 840 850 860 870 pF1KE6 AAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF :::::::: :::.:.::: :.. ::.::::::::::::::::::::.:::::::: .::: NP_005 AAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIF 840 850 860 870 880 890 880 890 900 910 920 930 pF1KE6 TVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQM ::::..:::::::::::.::::::.::::::::::.::::::::::::::::::::::.: NP_005 TVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHM 900 910 920 930 940 950 940 950 960 970 980 990 pF1KE6 RLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHA ::.::::.:::::::::.: ::: :. :::..:. . .:..::::.::::. . ... NP_005 RLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKS 960 970 980 990 1000 1010 1000 1010 1020 1030 1040 1050 pF1KE6 PDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEF ..:..:....::::::::::::::::::::..::.:.:::::::::::: ::::::::: NP_005 MEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEF 1020 1030 1040 1050 1060 1070 1060 1070 1080 pF1KE6 LEVLTEGLERVLLVRGGGREVITIYS :::::::::::::::::: ::::::: NP_005 LEVLTEGLERVLLVRGGGSEVITIYS 1080 1090 1085 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 15:47:02 2016 done: Tue Nov 8 15:47:04 2016 Total Scan time: 10.530 Total Display time: 0.480 Function used was FASTA [36.3.4 Apr, 2011]