FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5246, 480 aa 1>>>pF1KB5246 480 - 480 aa - 480 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1363+/-0.000413; mu= 15.5995+/- 0.026 mean_var=130.9327+/-24.996, 0's: 0 Z-trim(115.8): 94 B-trim: 308 in 1/54 Lambda= 0.112086 statistics sampled from 26482 (26587) to 26482 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.676), E-opt: 0.2 (0.312), width: 16 Scan time: 10.220 The best scores are: opt bits E(85289) NP_002766 (OMIM: 600142,602194,610149,616779) seri ( 480) 3174 524.9 1.9e-148 NP_710159 (OMIM: 610700) serine protease HTRA4 pre ( 476) 1613 272.5 1.8e-72 NP_444272 (OMIM: 608785) serine protease HTRA3 iso ( 453) 1547 261.8 2.9e-69 XP_011542733 (OMIM: 610700) PREDICTED: serine prot ( 380) 1295 221.0 4.7e-57 XP_011511898 (OMIM: 608785) PREDICTED: serine prot ( 373) 1260 215.3 2.3e-55 NP_001284488 (OMIM: 608785) serine protease HTRA3 ( 357) 1256 214.6 3.5e-55 XP_011542734 (OMIM: 610700) PREDICTED: serine prot ( 343) 1118 192.3 1.8e-48 NP_037379 (OMIM: 606441,610297) serine protease HT ( 458) 1107 190.7 7.5e-48 NP_001308657 (OMIM: 606441,610297) serine protease ( 426) 911 158.9 2.5e-38 NP_001308656 (OMIM: 606441,610297) serine protease ( 436) 711 126.6 1.4e-28 NP_001240764 (OMIM: 602867,614224) insulin-like gr ( 279) 377 72.4 1.8e-12 NP_001544 (OMIM: 602867,614224) insulin-like growt ( 282) 377 72.4 1.8e-12 NP_659540 (OMIM: 606441,610297) serine protease HT ( 361) 375 72.2 2.7e-12 XP_005270251 (OMIM: 609208) PREDICTED: kazal-type ( 230) 328 64.4 3.9e-10 XP_016872203 (OMIM: 609208) PREDICTED: kazal-type ( 304) 328 64.5 4.7e-10 XP_016872204 (OMIM: 609208) PREDICTED: kazal-type ( 304) 328 64.5 4.7e-10 NP_112191 (OMIM: 609208) kazal-type serine proteas ( 304) 328 64.5 4.7e-10 XP_016870188 (OMIM: 610413) PREDICTED: insulin-lik ( 174) 320 63.0 7.9e-10 NP_001007564 (OMIM: 610413) insulin-like growth fa ( 278) 320 63.2 1.1e-09 NP_000589 (OMIM: 146732) insulin-like growth facto ( 291) 216 46.4 0.00013 XP_016867641 (OMIM: 146732) PREDICTED: insulin-lik ( 291) 216 46.4 0.00013 NP_001013416 (OMIM: 146732) insulin-like growth fa ( 297) 216 46.4 0.00013 NP_000587 (OMIM: 146730) insulin-like growth facto ( 259) 196 43.1 0.0011 NP_001543 (OMIM: 146733) insulin-like growth facto ( 258) 194 42.8 0.0014 NP_001129076 (OMIM: 601521) endothelial cell-speci ( 134) 183 40.7 0.0031 NP_008967 (OMIM: 601521) endothelial cell-specific ( 184) 183 40.8 0.0038 NP_000590 (OMIM: 146734) insulin-like growth facto ( 272) 183 41.0 0.005 NP_002505 (OMIM: 164958) protein NOV homolog precu ( 357) 180 40.7 0.0085 >>NP_002766 (OMIM: 600142,602194,610149,616779) serine p (480 aa) initn: 3174 init1: 3174 opt: 3174 Z-score: 2786.2 bits: 524.9 E(85289): 1.9e-148 Smith-Waterman score: 3174; 100.0% identity (100.0% similar) in 480 aa overlap (1-480:1-480) 10 20 30 40 50 60 pF1KB5 MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 ACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 SDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 PAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 KIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 QRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 KKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 TPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP 430 440 450 460 470 480 >>NP_710159 (OMIM: 610700) serine protease HTRA4 precurs (476 aa) initn: 1618 init1: 1221 opt: 1613 Z-score: 1422.0 bits: 272.5 E(85289): 1.8e-72 Smith-Waterman score: 1628; 52.8% identity (77.5% similar) in 479 aa overlap (8-479:15-476) 10 20 30 40 50 pF1KB5 MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHC ::: :::::. :. .. .. : .:: :.:.::: : : NP_710 MIRPQLRTAGLGRCLLPGLLLLLV-PVLWAGAEKLHTQP---SCPAVCQPTRCPALPT-C 10 20 30 40 50 60 70 80 90 100 pF1KB5 EGGRAR--DACGCCEVCGAPEGAACGLQEG-PCGEGLQCVVPF--GVPASATVRRRAQAG : . : : ::.:: : : .:: .: ::. ::::. :. : :.. NP_710 ALGTTPVFDLCRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPST---------- 60 70 80 90 100 110 120 130 140 150 160 pF1KB5 LCVCAS-SEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQ-GQEDPNSLR : : . . ::::: :: ..: ::: .: ..:: . :.. .: : ::. : .. . :: NP_710 -CGCPTLGGAVCGSDRRTYPSMCALRAENRAARRLGKVPAVPVQWGNCGDTGTRSAGPLR 110 120 130 140 150 160 170 180 190 200 210 220 pF1KB5 HKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKH ..::::: ::::.::.:::..:. .: ..: ::: :::::::::::::.:::::: :.. NP_710 RNYNFIAAVVEKVAPSVVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQQ 170 180 190 200 210 220 230 240 250 260 270 280 pF1KB5 RVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPF ..: :.::: ::: .::.: : :.:.:::. ...::::.:::::.:: ::::::.:::: NP_710 WIEVVLQNGARYEAVVKDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSPF 230 240 250 260 270 280 290 300 310 320 330 340 pF1KB5 SLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLK :::::.:.::::: ::::::::...:::::.: :: :::::::::::::::.:::.:.:. NP_710 SLQNTATAGIVSTKQRGGKELGMKDSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSLR 290 300 310 320 330 340 350 360 370 380 390 400 pF1KB5 VTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFP :: :::::::::....::.: :..: ::::...:::.:..:.::: ..::: .. ::: NP_710 VTDGISFAIPSDRVRQFLAEYHEHQMKGKAFSNKKYLGLQMLSLTVPLSEELKMHYPDFP 350 360 370 380 390 400 410 420 430 440 450 460 pF1KB5 DVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGN :: ::.:. .:. : :...::...:::..:::. .....:: .. .: :.:.: ::. NP_710 DVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDS-LSMAVLRGK 410 420 430 440 450 460 470 480 pF1KB5 EDIMITVIPEEIDP .....::::: :. NP_710 DNLLLTVIPETIN 470 >>NP_444272 (OMIM: 608785) serine protease HTRA3 isoform (453 aa) initn: 1739 init1: 753 opt: 1547 Z-score: 1364.6 bits: 261.8 E(85289): 2.9e-69 Smith-Waterman score: 1716; 57.4% identity (78.0% similar) in 472 aa overlap (14-478:6-452) 10 20 30 40 50 60 pF1KB5 MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARD ::::: :. :.: : :: :: ::. .::: .:. : :: . : NP_444 MQARALLLAALAALALARE----PPAAPCPARCDVSRCP-SPR-CPGGYVPD 10 20 30 40 70 80 90 100 110 pF1KB5 ACGCCEVCGAPEGAACGLQ-EGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVC :.:: ::.: :: :: ..::::.:.:: ::: : :. :: NP_444 LCNCCLVCAASEGEPCGGPLDSPCGESLECV----------------RGLCRCRWSHAVC 50 60 70 80 90 120 130 140 150 160 170 pF1KB5 GSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKI :.:..::::.: :.:::::. .: :: ::.::: : .. .: :.:.:::::::::: NP_444 GTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKI 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB5 APAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTN------KHRVKVELK :::::::::: . :. :.::..::::::.:: :::.::::::.. ....::.:. NP_444 APAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQ 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB5 NGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVT :: .::: :::.:.:.::: ::: . ::::::::.:..::::::::::::::.:::::: NP_444 NGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVT 220 230 240 250 260 270 300 310 320 330 340 350 pF1KB5 TGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISF ::::::.:: :.:::::.:::::::::::::::::::::::::::::::::::::::::: NP_444 TGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISF 280 290 300 310 320 330 360 370 380 390 400 410 pF1KB5 AIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAY :::::.: .:::: .:.: : ::..::::: ..: : . ::: . :::.: :: : NP_444 AIPSDRITRFLTEFQDKQIKDW---KKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIY 340 350 360 370 380 420 430 440 450 460 470 pF1KB5 IIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITV . :: :..:.. ::....:.:...::. .:......... :: : . :::::.:..... NP_444 VQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEVRRGNDDLLFSI 390 400 410 420 430 440 480 pF1KB5 IPEEIDP :: . NP_444 APEVVM 450 >>XP_011542733 (OMIM: 610700) PREDICTED: serine protease (380 aa) initn: 1317 init1: 969 opt: 1295 Z-score: 1145.3 bits: 221.0 E(85289): 4.7e-57 Smith-Waterman score: 1310; 55.2% identity (75.9% similar) in 373 aa overlap (8-373:15-371) 10 20 30 40 50 pF1KB5 MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHC ::: :::::. :. .. .. : .:: :.:.::: : : XP_011 MIRPQLRTAGLGRCLLPGLLLLLV-PVLWAGAEKLHTQP---SCPAVCQPTRCPALPT-C 10 20 30 40 50 60 70 80 90 100 pF1KB5 EGGRAR--DACGCCEVCGAPEGAACGLQEG-PCGEGLQCVVPF--GVPASATVRRRAQAG : . : : ::.:: : : .:: .: ::. ::::. :. : :.. XP_011 ALGTTPVFDLCRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPST---------- 60 70 80 90 100 110 120 130 140 150 160 pF1KB5 LCVCAS-SEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQ-GQEDPNSLR : : . . ::::: :: ..: ::: .: ..:: . :.. .: : ::. : .. . :: XP_011 -CGCPTLGGAVCGSDRRTYPSMCALRAENRAARRLGKVPAVPVQWGNCGDTGTRSAGPLR 110 120 130 140 150 160 170 180 190 200 210 220 pF1KB5 HKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKH ..::::: ::::.::.:::..:. .: ..: ::: :::::::::::::.:::::: :.. XP_011 RNYNFIAAVVEKVAPSVVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQQ 170 180 190 200 210 220 230 240 250 260 270 280 pF1KB5 RVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPF ..: :.::: ::: .::.: : :.:.:::. ...::::.:::::.:: ::::::.:::: XP_011 WIEVVLQNGARYEAVVKDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSPF 230 240 250 260 270 280 290 300 310 320 330 340 pF1KB5 SLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLK :::::.:.::::: ::::::::...:::::.: :: :::::::::::::::.:::.:.:. XP_011 SLQNTATAGIVSTKQRGGKELGMKDSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSLR 290 300 310 320 330 340 350 360 370 380 390 400 pF1KB5 VTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFP :: :::::::::....::.: :..: : XP_011 VTDGISFAIPSDRVRQFLAEYHEHQMKEAKTIAAQS 350 360 370 380 >>XP_011511898 (OMIM: 608785) PREDICTED: serine protease (373 aa) initn: 1446 init1: 759 opt: 1260 Z-score: 1114.8 bits: 215.3 E(85289): 2.3e-55 Smith-Waterman score: 1429; 62.6% identity (78.6% similar) in 369 aa overlap (14-375:6-352) 10 20 30 40 50 60 pF1KB5 MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARD ::::: :. :.: : :: :: ::. .::: .:. : :: . : XP_011 MQARALLLAALAALALARE----PPAAPCPARCDVSRCP-SPR-CPGGYVPD 10 20 30 40 70 80 90 100 110 pF1KB5 ACGCCEVCGAPEGAACGLQ-EGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVC :.:: ::.: :: :: ..::::.:.:: ::: : :. :: XP_011 LCNCCLVCAASEGEPCGGPLDSPCGESLECV----------------RGLCRCRWSHAVC 50 60 70 80 90 120 130 140 150 160 170 pF1KB5 GSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKI :.:..::::.: :.:::::. .: :: ::.::: : .. .: :.:.:::::::::: XP_011 GTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKI 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB5 APAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTN------KHRVKVELK :::::::::: . :. :.::..::::::.:: :::.::::::.. ....::.:. XP_011 APAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQ 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB5 NGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVT :: .::: :::.:.:.::: ::: . ::::::::.:..::::::::::::::.:::::: XP_011 NGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVT 220 230 240 250 260 270 300 310 320 330 340 350 pF1KB5 TGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISF ::::::.:: :.:::::.:::::::::::::::::::::::::::::::::::::::::: XP_011 TGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISF 280 290 300 310 320 330 360 370 380 390 400 410 pF1KB5 AIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAY :::::.: .:::: .:.: :.: XP_011 AIPSDRITRFLTEFQDKQIKAKHMDPSAAKAGAMRAGHMKSCC 340 350 360 370 >>NP_001284488 (OMIM: 608785) serine protease HTRA3 isof (357 aa) initn: 1442 init1: 755 opt: 1256 Z-score: 1111.6 bits: 214.6 E(85289): 3.5e-55 Smith-Waterman score: 1425; 62.0% identity (78.4% similar) in 371 aa overlap (14-377:6-354) 10 20 30 40 50 60 pF1KB5 MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARD ::::: :. :.: : :: :: ::. .::: .:. : :: . : NP_001 MQARALLLAALAALALARE----PPAAPCPARCDVSRCP-SPR-CPGGYVPD 10 20 30 40 70 80 90 100 110 pF1KB5 ACGCCEVCGAPEGAACGLQ-EGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVC :.:: ::.: :: :: ..::::.:.:: ::: : :. :: NP_001 LCNCCLVCAASEGEPCGGPLDSPCGESLECV----------------RGLCRCRWSHAVC 50 60 70 80 90 120 130 140 150 160 170 pF1KB5 GSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKI :.:..::::.: :.:::::. .: :: ::.::: : .. .: :.:.:::::::::: NP_001 GTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKI 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB5 APAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTN------KHRVKVELK :::::::::: . :. :.::..::::::.:: :::.::::::.. ....::.:. NP_001 APAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQ 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB5 NGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVT :: .::: :::.:.:.::: ::: . ::::::::.:..::::::::::::::.:::::: NP_001 NGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVT 220 230 240 250 260 270 300 310 320 330 340 350 pF1KB5 TGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISF ::::::.:: :.:::::.:::::::::::::::::::::::::::::::::::::::::: NP_001 TGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISF 280 290 300 310 320 330 360 370 380 390 400 410 pF1KB5 AIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAY :::::.: .:::: .:.: :. .. NP_001 AIPSDRITRFLTEFQDKQIKAPSLAVH 340 350 >>XP_011542734 (OMIM: 610700) PREDICTED: serine protease (343 aa) initn: 1145 init1: 797 opt: 1118 Z-score: 991.2 bits: 192.3 E(85289): 1.8e-48 Smith-Waterman score: 1133; 54.3% identity (74.0% similar) in 335 aa overlap (8-335:15-333) 10 20 30 40 50 pF1KB5 MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHC ::: :::::. :. .. .. : .:: :.:.::: : : XP_011 MIRPQLRTAGLGRCLLPGLLLLLV-PVLWAGAEKLHTQP---SCPAVCQPTRCPALPT-C 10 20 30 40 50 60 70 80 90 100 pF1KB5 EGGRAR--DACGCCEVCGAPEGAACGLQEG-PCGEGLQCVVPF--GVPASATVRRRAQAG : . : : ::.:: : : .:: .: ::. ::::. :. : :.. XP_011 ALGTTPVFDLCRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPST---------- 60 70 80 90 100 110 120 130 140 150 160 pF1KB5 LCVCAS-SEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQ-GQEDPNSLR : : . . ::::: :: ..: ::: .: ..:: . :.. .: : ::. : .. . :: XP_011 -CGCPTLGGAVCGSDRRTYPSMCALRAENRAARRLGKVPAVPVQWGNCGDTGTRSAGPLR 110 120 130 140 150 160 170 180 190 200 210 220 pF1KB5 HKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKH ..::::: ::::.::.:::..:. .: ..: ::: :::::::::::::.:::::: :.. XP_011 RNYNFIAAVVEKVAPSVVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQQ 170 180 190 200 210 220 230 240 250 260 270 280 pF1KB5 RVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPF ..: :.::: ::: .::.: : :.:.:::. ...::::.:::::.:: ::::::.:::: XP_011 WIEVVLQNGARYEAVVKDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSPF 230 240 250 260 270 280 290 300 310 320 330 340 pF1KB5 SLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLK :::::.:.::::: ::::::::...:::::.: :: ::::::::::::: XP_011 SLQNTATAGIVSTKQRGGKELGMKDSDMDYVQIDATINYGNSGGPLVNLVFSLDLLTCL 290 300 310 320 330 340 350 360 370 380 390 400 pF1KB5 VTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFP >>NP_037379 (OMIM: 606441,610297) serine protease HTRA2, (458 aa) initn: 1103 init1: 869 opt: 1107 Z-score: 980.0 bits: 190.7 E(85289): 7.5e-48 Smith-Waterman score: 1107; 53.8% identity (81.6% similar) in 316 aa overlap (162-476:140-455) 140 150 160 170 180 190 pF1KB5 LRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRK : : : .:::::::::: :::::.::.. . NP_037 ALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDR 110 120 130 140 150 160 200 210 220 230 240 250 pF1KB5 LPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADI :: ::::...::::.:. :::::::::::....::.:.: .: :::: . :: ::: NP_037 HPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADI 170 180 190 200 210 220 260 270 280 290 300 310 pF1KB5 ALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN : ..:. . ::.: ::::...: ::::::.::::.::::.:.::::..:: ...::: . NP_037 ATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQ 230 240 250 260 270 280 320 330 340 350 360 370 pF1KB5 SDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQ ....:::::: :..::::::::::::::::.::.:::::::::::::....:: ... .. NP_037 TNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKN 290 300 310 320 330 340 380 390 400 410 420 430 pF1KB5 AK-GKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKE .. : . ....:::. :..:. : ::. :. .:::: :. : .:: .::. .::. NP_037 SSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRP 350 360 370 380 390 400 440 450 460 470 480 pF1KB5 NDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP .:::..:. : : .:.:: .... .: : . .::: : . . : :: NP_037 GDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE 410 420 430 440 450 >>NP_001308657 (OMIM: 606441,610297) serine protease HTR (426 aa) initn: 984 init1: 869 opt: 911 Z-score: 809.1 bits: 158.9 E(85289): 2.5e-38 Smith-Waterman score: 966; 50.0% identity (75.3% similar) in 316 aa overlap (162-476:140-423) 140 150 160 170 180 190 pF1KB5 LRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRK : : : .:::::::::: :::::.::.. . NP_001 ALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDR 110 120 130 140 150 160 200 210 220 230 240 250 pF1KB5 LPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADI :: ::::...::::.:. :::::::::::....::.:.: .: :::: . :: ::: NP_001 HPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADI 170 180 190 200 210 220 260 270 280 290 300 310 pF1KB5 ALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN : ..:. . ::.: ::::...: ::::::.::::.::::.:.::::..:: ...::: . NP_001 ATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQ 230 240 250 260 270 280 320 330 340 350 360 370 pF1KB5 SDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQ ....:::::: :..::::::::::::::::.::.:::::::::::::....:: ... .. NP_001 TNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKN 290 300 310 320 330 340 380 390 400 410 420 430 pF1KB5 AK-GKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKE .. : . ....:::. :..: : .: ::. NP_001 SSSGISGSQRRYIGVMMLTL-SPRA-------------------------------GLRP 350 360 370 440 450 460 470 480 pF1KB5 NDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP .:::..:. : : .:.:: .... .: : . .::: : . . : :: NP_001 GDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE 380 390 400 410 420 >>NP_001308656 (OMIM: 606441,610297) serine protease HTR (436 aa) initn: 825 init1: 710 opt: 711 Z-score: 634.2 bits: 126.6 E(85289): 1.4e-28 Smith-Waterman score: 936; 48.5% identity (73.0% similar) in 326 aa overlap (162-476:140-433) 140 150 160 170 180 190 pF1KB5 LRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRK : : : .:::::::::: :::::.::.. . NP_001 ALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDR 110 120 130 140 150 160 200 210 220 230 240 250 pF1KB5 LPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADI :: ::::...::::.:. :::::::::::....::.:.: .: :::: . :: ::: NP_001 HPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADI 170 180 190 200 210 220 260 270 280 290 300 310 pF1KB5 ALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN : ..:. . ::.: ::::...: ::::::.::::.::::.:.::::..:: ...::: . NP_001 ATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQ 230 240 250 260 270 280 320 330 340 350 360 pF1KB5 SDMDYIQTDAIINYGNSGGPLVNL----------DGEVIGINTLKVTAGISFAIPSDKIK ....:::::: :..:::::::::: ::::::.::.:::::::::::::... NP_001 TNVEYIQTDAAIDFGNSGGPLVNLARELGAVSLQDGEVIGVNTMKVTAGISFAIPSDRLR 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB5 KFLTESHDRQAK-GKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPD .:: ... .... : . ....:::. :..: : .: NP_001 EFLHRGEKKNSSSGISGSQRRYIGVMMLTL-SPRA------------------------- 350 360 370 380 430 440 450 460 470 480 pF1KB5 TPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP ::. .:::..:. : : .:.:: .... .: : . .::: : . . : :: NP_001 ------GLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE 390 400 410 420 430 480 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 20:20:34 2016 done: Sun Nov 6 20:20:35 2016 Total Scan time: 10.220 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]