FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1685, 197 aa 1>>>pF1KE1685 197 - 197 aa - 197 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4676+/-0.000266; mu= 13.3622+/- 0.017 mean_var=74.6536+/-14.994, 0's: 0 Z-trim(120.4): 16 B-trim: 40 in 1/57 Lambda= 0.148439 statistics sampled from 35684 (35702) to 35684 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.783), E-opt: 0.2 (0.419), width: 16 Scan time: 6.640 The best scores are: opt bits E(85289) NP_037410 (OMIM: 604628) interleukin-17C precursor ( 197) 1393 306.6 1.7e-83 NP_612141 (OMIM: 607587) interleukin-17D precursor ( 202) 272 66.5 3.2e-11 XP_005266478 (OMIM: 607587) PREDICTED: interleukin ( 209) 272 66.6 3.2e-11 NP_758525 (OMIM: 605658) interleukin-25 isoform 2 ( 161) 223 56.0 3.8e-08 NP_073626 (OMIM: 605658) interleukin-25 isoform 1 ( 177) 223 56.0 4.1e-08 NP_055258 (OMIM: 604627) interleukin-17B isoform 1 ( 180) 201 51.3 1.1e-06 XP_016864835 (OMIM: 604627) PREDICTED: interleukin ( 245) 200 51.2 1.6e-06 XP_016864836 (OMIM: 604627) PREDICTED: interleukin ( 128) 196 50.1 1.7e-06 XP_016864837 (OMIM: 604627) PREDICTED: interleukin ( 128) 196 50.1 1.7e-06 NP_001304916 (OMIM: 604627) interleukin-17B isofor ( 128) 196 50.1 1.7e-06 XP_011535924 (OMIM: 604627) PREDICTED: interleukin ( 128) 196 50.1 1.7e-06 XP_005266479 (OMIM: 607587) PREDICTED: interleukin ( 114) 191 49.0 3.3e-06 XP_011512578 (OMIM: 606496,613956) PREDICTED: inte ( 163) 183 47.4 1.5e-05 NP_443104 (OMIM: 606496,613956) interleukin-17F pr ( 163) 183 47.4 1.5e-05 NP_002181 (OMIM: 603149) interleukin-17A precursor ( 155) 167 44.0 0.00015 >>NP_037410 (OMIM: 604628) interleukin-17C precursor [Ho (197 aa) initn: 1393 init1: 1393 opt: 1393 Z-score: 1620.1 bits: 306.6 E(85289): 1.7e-83 Smith-Waterman score: 1393; 100.0% identity (100.0% similar) in 197 aa overlap (1-197:1-197) 10 20 30 40 50 60 pF1KE1 MTLLPGLLFLTWLHTCLAHHDPSLRGHPHSHGTPHCYSAEELPLGQAPPHLLARGAKWGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 MTLLPGLLFLTWLHTCLAHHDPSLRGHPHSHGTPHCYSAEELPLGQAPPHLLARGAKWGQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 ALPVALVSSLEAASHRGRHERPSATTQCPVLRPEEVLEADTHQRSISPWRYRVDTDEDRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 ALPVALVSSLEAASHRGRHERPSATTQCPVLRPEEVLEADTHQRSISPWRYRVDTDEDRY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 PQKLAFAECLCRGCIDARTGRETAALNSVRLLQSLLVLRRRPCSRDGSGLPTPGAFAFHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 PQKLAFAECLCRGCIDARTGRETAALNSVRLLQSLLVLRRRPCSRDGSGLPTPGAFAFHT 130 140 150 160 170 180 190 pF1KE1 EFIHVPVGCTCVLPRSV ::::::::::::::::: NP_037 EFIHVPVGCTCVLPRSV 190 >>NP_612141 (OMIM: 607587) interleukin-17D precursor [Ho (202 aa) initn: 285 init1: 203 opt: 272 Z-score: 322.5 bits: 66.5 E(85289): 3.2e-11 Smith-Waterman score: 272; 32.7% identity (59.4% similar) in 165 aa overlap (32-192:17-170) 10 20 30 40 50 pF1KE1 TLLPGLLFLTWLHTCLAHHDPSLRGHPHSHGTPHCYSAEELPLGQA--PPHLLARGAKWG :.:. : : : : .:: . .: NP_612 MLVAGFLLALPPSWAAGAPRAGRRPARPRGCADRPEELLEQ--LYG 10 20 30 40 60 70 80 90 100 110 pF1KE1 QALPVALVSSLEAASHRGRHERPSATTQCPVL-RP-EEVLEADTHQRSISPWRYRVDTDE . : ....:... . . : .:. .. ::. :: .. .. :. ::.::: ::.. : NP_612 R-LAAGVLSAFHHTLQLGPREQARNAS-CPAGGRPADRRFRPPTNLRSVSPWAYRISYDP 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 DRYPQKLAFAECLCRGCIDARTGRETAALNSVRLLQSLLVLRRRPCSRDGSGLPTPGAFA :::. : : ::::::. . :.: . . :. . . .:::: : : .. : . NP_612 ARYPRYLPEAYCLCRGCLTGLFGEEDVRFRSAPVYMPTVVLRRTPACAGGRSVYTEA--- 110 120 130 140 150 180 190 pF1KE1 FHTEFIHVPVGCTCVLPRSV .. .::::::: NP_612 ----YVTIPVGCTCVPEPEKDADSINSSIDKQGAKLLLGPNDAPAGP 160 170 180 190 200 >>XP_005266478 (OMIM: 607587) PREDICTED: interleukin-17D (209 aa) initn: 285 init1: 203 opt: 272 Z-score: 322.3 bits: 66.6 E(85289): 3.2e-11 Smith-Waterman score: 272; 32.7% identity (59.4% similar) in 165 aa overlap (32-192:24-177) 10 20 30 40 50 pF1KE1 TLLPGLLFLTWLHTCLAHHDPSLRGHPHSHGTPHCYSAEELPLGQA--PPHLLARGAKWG :.:. : : : : .:: . .: XP_005 MLGALVWMLVAGFLLALPPSWAAGAPRAGRRPARPRGCADRPEELLEQ--LYG 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 QALPVALVSSLEAASHRGRHERPSATTQCPVL-RP-EEVLEADTHQRSISPWRYRVDTDE . : ....:... . . : .:. .. ::. :: .. .. :. ::.::: ::.. : XP_005 R-LAAGVLSAFHHTLQLGPREQARNAS-CPAGGRPADRRFRPPTNLRSVSPWAYRISYDP 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 DRYPQKLAFAECLCRGCIDARTGRETAALNSVRLLQSLLVLRRRPCSRDGSGLPTPGAFA :::. : : ::::::. . :.: . . :. . . .:::: : : .. : . XP_005 ARYPRYLPEAYCLCRGCLTGLFGEEDVRFRSAPVYMPTVVLRRTPACAGGRSVYTEA--- 110 120 130 140 150 160 180 190 pF1KE1 FHTEFIHVPVGCTCVLPRSV .. .::::::: XP_005 ----YVTIPVGCTCVPEPEKDADSINSSIDKQGAKLLLGPNDAPAGP 170 180 190 200 >>NP_758525 (OMIM: 605658) interleukin-25 isoform 2 prec (161 aa) initn: 199 init1: 159 opt: 223 Z-score: 267.3 bits: 56.0 E(85289): 3.8e-08 Smith-Waterman score: 230; 33.5% identity (55.3% similar) in 170 aa overlap (27-195:15-158) 10 20 30 40 50 60 pF1KE1 MTLLPGLLFLTWLHTCLAHHDPSLRGHPHSHGTPHCYSAEELPLGQAPPHLLARGAKWGQ : .:: : : .. :: . : : :. NP_758 MYQVVAFLAMVMGTHTYSHW-PSCCPSK----GQDTSEELLR---WS- 10 20 30 70 80 90 100 110 120 pF1KE1 ALPVALVSSLEAASHRGRHERPSATTQCPVLRPEEVLEADTHQRSISPWRYRVDTDEDRY ..:: :: : .:: : . : : : .. ..:.::::::..: : .: NP_758 TVPVP---PLEPARP-NRH--PES---C---RASE--DGPLNSRAISPWRYELDRDLNRL 40 50 60 70 80 130 140 150 160 170 pF1KE1 PQKLAFAECLCRGCIDARTGRETAAL-NSVRLLQSLLVLRRRPCSRDGSGLPTPGAFAFH :: : :.::: :.. .:: . :: : .. :. :::: . .: : .. .. NP_758 PQDLYHARCLCPHCVSLQTGSHMDPRGNSELLYHNQTVFYRRPCHGE-KG--THKGYCLE 90 100 110 120 130 140 180 190 pF1KE1 TEFIHVPVGCTCVLPRSV .. .: ..:.:: :: NP_758 RRLYRVSLACVCVRPRVMG 150 160 >>NP_073626 (OMIM: 605658) interleukin-25 isoform 1 prec (177 aa) initn: 199 init1: 159 opt: 223 Z-score: 266.7 bits: 56.0 E(85289): 4.1e-08 Smith-Waterman score: 230; 33.5% identity (55.3% similar) in 170 aa overlap (27-195:31-174) 10 20 30 40 50 pF1KE1 MTLLPGLLFLTWLHTCLAHHDPSLRGHPHSHGTPHCYSAEELPLGQAPPHLLARGA : .:: : : .. :: . : : NP_073 MRERPRLGEDSSLISLFLQVVAFLAMVMGTHTYSHW-PSCCPSK----GQDTSEELLR-- 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 KWGQALPVALVSSLEAASHRGRHERPSATTQCPVLRPEEVLEADTHQRSISPWRYRVDTD :. ..:: :: : .:: : . : : : .. ..:.::::::..: : NP_073 -WS-TVPVP---PLEPARP-NRH--PES---C---RASE--DGPLNSRAISPWRYELDRD 60 70 80 90 120 130 140 150 160 170 pF1KE1 EDRYPQKLAFAECLCRGCIDARTGRETAAL-NSVRLLQSLLVLRRRPCSRDGSGLPTPGA .: :: : :.::: :.. .:: . :: : .. :. :::: . .: : . NP_073 LNRLPQDLYHARCLCPHCVSLQTGSHMDPRGNSELLYHNQTVFYRRPCHGE-KG--THKG 100 110 120 130 140 150 180 190 pF1KE1 FAFHTEFIHVPVGCTCVLPRSV . .. .. .: ..:.:: :: NP_073 YCLERRLYRVSLACVCVRPRVMG 160 170 >>NP_055258 (OMIM: 604627) interleukin-17B isoform 1 pre (180 aa) initn: 197 init1: 162 opt: 201 Z-score: 241.1 bits: 51.3 E(85289): 1.1e-06 Smith-Waterman score: 205; 30.2% identity (53.5% similar) in 159 aa overlap (45-193:31-180) 20 30 40 50 60 70 pF1KE1 TCLAHHDPSLRGHPHSHGTPHCYSAEELPLGQAPPHLLARGAKWGQALPVALVSSLEAAS ::. : :: : . .:. ::: .. . NP_055 MDWPHNLLFLLTISIFLGLGQPRSPKSKRKGQGRPGPLAPGP---HQVPLDLVSRMKPYA 10 20 30 40 50 80 90 100 110 120 pF1KE1 HRGRHERPSATTQCPVLRPEEVL-----EAD-----THQRSISPWRYRVDTDEDRYPQKL . ..:: . . :: : :.. ...::.::: : .. : .: : : NP_055 RMEEYER-NIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 AFAECLCRGCIDARTGRETAALNSVRLLQSLLVLRRRPCSRDGSGLPTPGAFAFHTEFIH :.::: ::.. : .: .. :: .. : . .::: : : : .. . NP_055 PEARCLCLGCVNPFTMQEDRSMVSVPVF-SQVPVRRRLCPPP----PRTGPCRQRAVMET 120 130 140 150 160 170 190 pF1KE1 VPVGCTCVLPRSV . :::::.. NP_055 IAVGCTCIF 180 >>XP_016864835 (OMIM: 604627) PREDICTED: interleukin-17B (245 aa) initn: 197 init1: 162 opt: 200 Z-score: 238.0 bits: 51.2 E(85289): 1.6e-06 Smith-Waterman score: 205; 30.2% identity (53.5% similar) in 159 aa overlap (45-193:96-245) 20 30 40 50 60 70 pF1KE1 TCLAHHDPSLRGHPHSHGTPHCYSAEELPLGQAPPHLLARGAKWGQALPVALVSSLEAAS ::. : :: : . .:. ::: .. . XP_016 GRPGQSALFLLTISIFLGLGQPRSPKSKRKGQGRPGPLAPGP---HQVPLDLVSRMKPYA 70 80 90 100 110 120 80 90 100 110 120 pF1KE1 HRGRHERPSATTQCPVLRPEEVL-----EAD-----THQRSISPWRYRVDTDEDRYPQKL . ..:: . . :: : :.. ...::.::: : .. : .: : : XP_016 RMEEYER-NIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDL 130 140 150 160 170 180 130 140 150 160 170 180 pF1KE1 AFAECLCRGCIDARTGRETAALNSVRLLQSLLVLRRRPCSRDGSGLPTPGAFAFHTEFIH :.::: ::.. : .: .. :: .. : . .::: : : : .. . XP_016 PEARCLCLGCVNPFTMQEDRSMVSVPVF-SQVPVRRRLCPPP----PRTGPCRQRAVMET 190 200 210 220 230 190 pF1KE1 VPVGCTCVLPRSV . :::::.. XP_016 IAVGCTCIF 240 >>XP_016864836 (OMIM: 604627) PREDICTED: interleukin-17B (128 aa) initn: 213 init1: 162 opt: 196 Z-score: 237.5 bits: 50.1 E(85289): 1.7e-06 Smith-Waterman score: 196; 34.4% identity (60.2% similar) in 93 aa overlap (101-193:41-128) 80 90 100 110 120 130 pF1KE1 EAASHRGRHERPSATTQCPVLRPEEVLEADTHQRSISPWRYRVDTDEDRYPQKLAFAECL ...::.::: : .. : .: : : :.:: XP_016 ERNIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCL 20 30 40 50 60 70 140 150 160 170 180 190 pF1KE1 CRGCIDARTGRETAALNSVRLLQSLLVLRRRPCSRDGSGLPTPGAFAFHTEFIHVPVGCT : ::.. : .: .. :: ..... : ::: : : : .. . . :::: XP_016 CLGCVNPFTMQEDRSMVSVPVFSQVPV-RRRLCPPP----PRTGPCRQRAVMETIAVGCT 80 90 100 110 120 pF1KE1 CVLPRSV :.. XP_016 CIF >>XP_016864837 (OMIM: 604627) PREDICTED: interleukin-17B (128 aa) initn: 213 init1: 162 opt: 196 Z-score: 237.5 bits: 50.1 E(85289): 1.7e-06 Smith-Waterman score: 196; 34.4% identity (60.2% similar) in 93 aa overlap (101-193:41-128) 80 90 100 110 120 130 pF1KE1 EAASHRGRHERPSATTQCPVLRPEEVLEADTHQRSISPWRYRVDTDEDRYPQKLAFAECL ...::.::: : .. : .: : : :.:: XP_016 ERNIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCL 20 30 40 50 60 70 140 150 160 170 180 190 pF1KE1 CRGCIDARTGRETAALNSVRLLQSLLVLRRRPCSRDGSGLPTPGAFAFHTEFIHVPVGCT : ::.. : .: .. :: ..... : ::: : : : .. . . :::: XP_016 CLGCVNPFTMQEDRSMVSVPVFSQVPV-RRRLCPPP----PRTGPCRQRAVMETIAVGCT 80 90 100 110 120 pF1KE1 CVLPRSV :.. XP_016 CIF >>NP_001304916 (OMIM: 604627) interleukin-17B isoform 2 (128 aa) initn: 213 init1: 162 opt: 196 Z-score: 237.5 bits: 50.1 E(85289): 1.7e-06 Smith-Waterman score: 196; 34.4% identity (60.2% similar) in 93 aa overlap (101-193:41-128) 80 90 100 110 120 130 pF1KE1 EAASHRGRHERPSATTQCPVLRPEEVLEADTHQRSISPWRYRVDTDEDRYPQKLAFAECL ...::.::: : .. : .: : : :.:: NP_001 ERNIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCL 20 30 40 50 60 70 140 150 160 170 180 190 pF1KE1 CRGCIDARTGRETAALNSVRLLQSLLVLRRRPCSRDGSGLPTPGAFAFHTEFIHVPVGCT : ::.. : .: .. :: ..... : ::: : : : .. . . :::: NP_001 CLGCVNPFTMQEDRSMVSVPVFSQVPV-RRRLCPPP----PRTGPCRQRAVMETIAVGCT 80 90 100 110 120 pF1KE1 CVLPRSV :.. NP_001 CIF 197 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 15:26:44 2016 done: Mon Nov 7 15:26:45 2016 Total Scan time: 6.640 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]