FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4089, 453 aa 1>>>pF1KE4089 453 - 453 aa - 453 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.4535+/-0.000483; mu= 12.5369+/- 0.030 mean_var=174.8247+/-36.931, 0's: 0 Z-trim(116.0): 565 B-trim: 678 in 1/51 Lambda= 0.097000 statistics sampled from 26147 (26848) to 26147 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.668), E-opt: 0.2 (0.315), width: 16 Scan time: 8.290 The best scores are: opt bits E(85289) NP_543139 (OMIM: 615056) ankyrin repeat and SOCS b ( 453) 3078 443.6 5e-124 NP_543147 (OMIM: 603383,615054) ankyrin repeat and ( 452) 736 115.9 2.3e-25 NP_001135932 (OMIM: 603383,615054) ankyrin repeat ( 429) 602 97.1 9.9e-20 NP_001135931 (OMIM: 603383,615054) ankyrin repeat ( 467) 602 97.1 1e-19 NP_057200 (OMIM: 605761) ankyrin repeat and SOCS b ( 426) 562 91.5 4.8e-18 XP_016867792 (OMIM: 605761) PREDICTED: ankyrin rep ( 368) 552 90.0 1.1e-17 NP_665879 (OMIM: 605761) ankyrin repeat and SOCS b ( 349) 496 82.1 2.5e-15 NP_001183959 (OMIM: 610500) ankyrin repeat and KH ( 581) 320 57.8 9e-08 NP_060448 (OMIM: 610500) ankyrin repeat and KH dom ( 616) 320 57.8 9.4e-08 NP_078944 (OMIM: 610500) ankyrin repeat and KH dom ( 627) 320 57.8 9.5e-08 XP_016863506 (OMIM: 615929) PREDICTED: ankyrin rep (1116) 318 57.9 1.7e-07 XP_016863505 (OMIM: 615929) PREDICTED: ankyrin rep (1229) 318 57.9 1.8e-07 XP_016863504 (OMIM: 615929) PREDICTED: ankyrin rep (1367) 318 58.0 1.9e-07 XP_016863503 (OMIM: 615929) PREDICTED: ankyrin rep (1479) 318 58.0 2e-07 XP_005265730 (OMIM: 615929) PREDICTED: ankyrin rep (1480) 318 58.0 2e-07 XP_005265729 (OMIM: 615929) PREDICTED: ankyrin rep (1543) 318 58.0 2e-07 XP_016861518 (OMIM: 611122) PREDICTED: serine/thre ( 681) 312 56.8 2.2e-07 XP_016861517 (OMIM: 611122) PREDICTED: serine/thre ( 687) 312 56.8 2.2e-07 NP_060217 (OMIM: 610500) ankyrin repeat and KH dom (2542) 320 58.6 2.3e-07 XP_016863502 (OMIM: 615929) PREDICTED: ankyrin rep (2238) 318 58.2 2.6e-07 XP_016863501 (OMIM: 615929) PREDICTED: ankyrin rep (2239) 318 58.2 2.6e-07 NP_001182027 (OMIM: 611122) serine/threonine-prote ( 899) 312 56.9 2.6e-07 NP_001182028 (OMIM: 611122) serine/threonine-prote ( 899) 312 56.9 2.6e-07 XP_016861515 (OMIM: 611122) PREDICTED: serine/thre ( 899) 312 56.9 2.6e-07 XP_016861516 (OMIM: 611122) PREDICTED: serine/thre ( 899) 312 56.9 2.6e-07 XP_005265728 (OMIM: 615929) PREDICTED: ankyrin rep (2351) 318 58.3 2.6e-07 NP_942592 (OMIM: 615929) ankyrin repeat domain-con (2352) 318 58.3 2.6e-07 XP_016863500 (OMIM: 615929) PREDICTED: ankyrin rep (2489) 318 58.3 2.7e-07 NP_001273700 (OMIM: 615929) ankyrin repeat domain- (2490) 318 58.3 2.7e-07 XP_011531849 (OMIM: 611122) PREDICTED: serine/thre ( 997) 312 57.0 2.8e-07 XP_011531847 (OMIM: 611122) PREDICTED: serine/thre ( 997) 312 57.0 2.8e-07 XP_011531848 (OMIM: 611122) PREDICTED: serine/thre ( 997) 312 57.0 2.8e-07 XP_011531845 (OMIM: 611122) PREDICTED: serine/thre (1019) 312 57.0 2.8e-07 XP_011531844 (OMIM: 611122) PREDICTED: serine/thre (1025) 312 57.0 2.8e-07 NP_056389 (OMIM: 615929) ankyrin repeat domain-con (2602) 318 58.3 2.8e-07 XP_011531843 (OMIM: 611122) PREDICTED: serine/thre (1027) 312 57.0 2.8e-07 NP_115593 (OMIM: 615929) ankyrin repeat domain-con (2603) 318 58.3 2.8e-07 NP_056014 (OMIM: 611122) serine/threonine-protein (1053) 312 57.0 2.9e-07 XP_005265053 (OMIM: 611122) PREDICTED: serine/thre (1083) 312 57.0 2.9e-07 XP_011531842 (OMIM: 611122) PREDICTED: serine/thre (1086) 312 57.0 2.9e-07 NP_001306226 (OMIM: 615053) ankyrin repeat and SOC ( 288) 282 52.1 2.3e-06 NP_001306225 (OMIM: 615053) ankyrin repeat and SOC ( 288) 282 52.1 2.3e-06 NP_077000 (OMIM: 615053) ankyrin repeat and SOCS b ( 288) 282 52.1 2.3e-06 NP_001306228 (OMIM: 615053) ankyrin repeat and SOC ( 227) 274 50.8 4.4e-06 NP_001306227 (OMIM: 615053) ankyrin repeat and SOC ( 227) 274 50.8 4.4e-06 NP_004548 (OMIM: 164951) neurogenic locus notch ho (2003) 280 52.9 9.5e-06 NP_078977 (OMIM: 615055) ankyrin repeat and SOCS b ( 278) 262 49.3 1.6e-05 XP_011543762 (OMIM: 300890) PREDICTED: ankyrin rep ( 233) 245 46.8 7.4e-05 XP_011543760 (OMIM: 300890) PREDICTED: ankyrin rep ( 265) 245 46.9 8e-05 XP_016884773 (OMIM: 300890) PREDICTED: ankyrin rep ( 348) 245 47.0 9.5e-05 >>NP_543139 (OMIM: 615056) ankyrin repeat and SOCS box p (453 aa) initn: 3078 init1: 3078 opt: 3078 Z-score: 2347.6 bits: 443.6 E(85289): 5e-124 Smith-Waterman score: 3078; 99.8% identity (100.0% similar) in 453 aa overlap (1-453:1-453) 10 20 30 40 50 60 pF1KE4 MARETFPFTSSMLRSLRLQQEWLEWEDRRRAAAQQCRSRRCPSSPRARLTRPHRSCRDPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 MARETFPFTSSMLRSLRLQQEWLEWEDRRRAAAQQCRSRRCPSSPRARLTRPHRSCRDPA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VHHALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFWVLTPKTKQTAPLAIATA ::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 VHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFWVLTPKTKQTAPLAIATA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 RGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 RGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 HLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 HLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 SQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 SQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 ELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRPEMLKHCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 ELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRPEMLKHCA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 NFPRALEVLLNAYPCVPSCETWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 NFPRALEVLLNAYPCVPSCETWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVR 370 380 390 400 410 420 430 440 450 pF1KE4 ARLGSRCRQGATRLPLPPLLRDYLLLRVEGCIQ ::::::::::::::::::::::::::::::::: NP_543 ARLGSRCRQGATRLPLPPLLRDYLLLRVEGCIQ 430 440 450 >>NP_543147 (OMIM: 603383,615054) ankyrin repeat and SOC (452 aa) initn: 881 init1: 424 opt: 736 Z-score: 576.3 bits: 115.9 E(85289): 2.3e-25 Smith-Waterman score: 971; 40.5% identity (65.0% similar) in 432 aa overlap (32-452:20-451) 10 20 30 40 50 60 pF1KE4 ARETFPFTSSMLRSLRLQQEWLEWEDRRRAAAQQCRSRRCPSSPRARLTRPHRS-CRDPA .: :: : : : . :: :.: : NP_543 MPWGKNSSPHWGHHLGCLPSAPACRIWRPHSRPAWEPPRPSPLLCQDMA 10 20 30 40 70 80 90 100 110 pF1KE4 VHHALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQ-GFWVLTPKTKQTAPLAIAT ...::..:.: ..: :: . .:....:. . . ::..: :.: :: . . :.:: .:. NP_543 LQNALYTGDLARLQELFPPHSTADLLLESRAAEPRWSSHQRGLWSLTYEEELTTPLHVAA 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE4 ARGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTP .::.:. : :.:. :. :. :::.::::::: .. ::..::. :: :. ..: : NP_543 SRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRP 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE4 LHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLR :::: : .:.::.:::. :: :. . : .:::::::: : . . : :..:: : NP_543 LHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDAR 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE4 TSQGETALNTAC-----AGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACAN ...: : : .:: . ... .. : :: ::::: :: . .. ::: :: NP_543 NAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRR 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE4 GCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRP- : ....:::: :. :.. . .::::. ::::. . :: . :::..:: : : NP_543 GHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPG 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE4 ---EMLKHCANFPRALEVLLNAYPCVPSCETWVEAVLPELWKEHEAFYSSALCMVNQPRQ ..:.. .. ::..:::.:.: : : : : :: ..:. :::: . .: :::. NP_543 ALPKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRS 350 360 370 380 390 400 420 430 440 450 pF1KE4 LQHLARLAVRARLGSRCRQGATRLPLPPLLRDYLLLRVEGCIQ ::::.: :.:..: . :. :::::: : :: : :: . NP_543 LQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 410 420 430 440 450 >>NP_001135932 (OMIM: 603383,615054) ankyrin repeat and (429 aa) initn: 768 init1: 410 opt: 602 Z-score: 475.2 bits: 97.1 E(85289): 9.9e-20 Smith-Waterman score: 721; 36.6% identity (58.8% similar) in 415 aa overlap (54-452:49-428) 30 40 50 60 70 80 pF1KE4 EWEDRRRAAAQQCRSRRCPSSPRARLTRPHRSCRDPAVH--HALFSGNLQQVQALFQDEE :. ::. .:...:.. :. .. : NP_001 DRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSS 20 30 40 50 60 70 90 100 110 120 130 pF1KE4 ---AANMIVETVSNQLAWSAEQ------GFWVLTPKTKQTAPLAIATARGYTDCARHLIR : . . .: :. : . .: :: . . :.:: .:..::.:. : :.: NP_001 TGLAPDSVFDT-SDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLR 80 90 100 110 120 130 140 150 160 170 180 190 pF1KE4 QGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCA . :. :. :::.::::::: .. ::..::. :: :. ..: ::::: : .:.:: NP_001 RRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECA 140 150 160 170 180 190 200 210 220 230 240 250 pF1KE4 KLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTAC- .:::. :: :. . : .:::::::: : . . : :..:: :...: : : .:: NP_001 ELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACD 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 ----AGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYG . ... .. : :: ::::: :: . .. ::: :: : ....:::: : NP_001 VRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCG 260 270 280 290 300 310 310 320 330 340 350 360 pF1KE4 ARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRPEMLKHCANFPRALE . :.. . .::::. ::::. . :: . :::..:: :: NP_001 VSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA--VR--------------- 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 VLLNAYPCVPSCETWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVRARLGSRC .: ..:: :.:. :::: . .: :::.::::.: :.:..: . NP_001 -------------VW-PGALP---KKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSL 370 380 390 400 430 440 450 pF1KE4 RQGATRLPLPPLLRDYLLLRVEGCIQ :. :::::: : :: : :: . NP_001 PQALPRLPLPPRLLRYLQLDFEGVLY 410 420 >>NP_001135931 (OMIM: 603383,615054) ankyrin repeat and (467 aa) initn: 867 init1: 410 opt: 602 Z-score: 474.8 bits: 97.1 E(85289): 1e-19 Smith-Waterman score: 841; 38.7% identity (62.5% similar) in 419 aa overlap (54-452:49-466) 30 40 50 60 70 80 pF1KE4 EWEDRRRAAAQQCRSRRCPSSPRARLTRPHRSCRDPAVH--HALFSGNLQQVQALFQDEE :. ::. .:...:.. :. .. : NP_001 DRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSS 20 30 40 50 60 70 90 100 110 120 130 pF1KE4 ---AANMIVETVSNQLAWSAEQ------GFWVLTPKTKQTAPLAIATARGYTDCARHLIR : . . .: :. : . .: :: . . :.:: .:..::.:. : :.: NP_001 TGLAPDSVFDT-SDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLR 80 90 100 110 120 130 140 150 160 170 180 190 pF1KE4 QGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCA . :. :. :::.::::::: .. ::..::. :: :. ..: ::::: : .:.:: NP_001 RRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECA 140 150 160 170 180 190 200 210 220 230 240 250 pF1KE4 KLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTAC- .:::. :: :. . : .:::::::: : . . : :..:: :...: : : .:: NP_001 ELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACD 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 ----AGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYG . ... .. : :: ::::: :: . .. ::: :: : ....:::: : NP_001 VRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCG 260 270 280 290 300 310 310 320 330 340 350 360 pF1KE4 ARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRP----EMLKHCANFP . :.. . .::::. ::::. . :: . :::..:: : : ..:.. .. : NP_001 VSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCP 320 330 340 350 360 370 370 380 390 400 410 420 pF1KE4 RALEVLLNAYPCVPSCETWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVRARL :..:::.:.: : : : : :: ..:. :::: . .: :::.::::.: :.:..: NP_001 RTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRSHL 380 390 400 410 420 430 430 440 450 pF1KE4 GSRCRQGATRLPLPPLLRDYLLLRVEGCIQ . :. :::::: : :: : :: . NP_001 EGSLPQALPRLPLPPRLLRYLQLDFEGVLY 440 450 460 >>NP_057200 (OMIM: 605761) ankyrin repeat and SOCS box p (426 aa) initn: 599 init1: 221 opt: 562 Z-score: 445.0 bits: 91.5 E(85289): 4.8e-18 Smith-Waterman score: 687; 33.5% identity (62.5% similar) in 403 aa overlap (64-452:24-425) 40 50 60 70 80 90 pF1KE4 QQCRSRRCPSSPRARLTRPHRSCRDPAVHHALFSGNLQQVQA-LFQDEEAANMIVETVS- :: :... ...: :.: . .. . :. . NP_057 MDGTTAPVTKSGAAKLVKRNFLEALKSNDFGKLKAILIQRQIDVDTVFEVEDE 10 20 30 40 50 100 110 120 130 140 pF1KE4 NQLAWSAEQGFWVLTPKTKQT--APLAIATARGYTDCARHLIRQGAELDARVGGRAALHE :.. : .::.:. . : :.. . : ... :...: :. ..: .. : .:.. :: NP_057 NMVLASYKQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHV 60 70 80 90 100 110 150 160 170 180 190 200 pF1KE4 ACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAG-E :: :. :::..: ::: : . : : ::.:: : :. ::: :. ::.::. .. . NP_057 ACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQ 120 130 140 150 160 170 210 220 230 240 250 260 pF1KE4 SQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGA---EGPGSCRRHQA ..:::::.:: :: . ::.:.:::: : ... :: : : : . .:. NP_057 DEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHL 180 190 200 210 220 230 270 280 290 300 310 320 pF1KE4 AARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCAL . : ::. :.. : ..:::.: : : ...:. ::.:.. . : . .. .: NP_057 VCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVL 240 250 260 270 280 290 330 340 350 360 370 380 pF1KE4 QAVQDSPNWEPEVLFAALLDYGAQPVRP----EMLKHCANFPRALEVLLNAYPCVPSCET .... : .::. . ::..:: . : .... : . :.:.::..::: . NP_057 KVTSVRPAAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWNTK 300 310 320 330 340 350 390 400 410 420 430 pF1KE4 WVEAVLPELWKEHEAFYSS--ALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLPLPPL : .:. . ... :: : ..: :.:: :.::.: :.: : .::... : :: NP_057 WRRAIPDDDLEKYWDFYHSLFTVC-CNSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLPLS 360 370 380 390 400 410 440 450 pF1KE4 LRDYLLLRVEGCIQ :. ::::. :: : NP_057 LKKYLLLEPEGIIY 420 >>XP_016867792 (OMIM: 605761) PREDICTED: ankyrin repeat (368 aa) initn: 482 init1: 221 opt: 552 Z-score: 438.2 bits: 90.0 E(85289): 1.1e-17 Smith-Waterman score: 552; 32.7% identity (62.5% similar) in 336 aa overlap (64-386:24-358) 40 50 60 70 80 90 pF1KE4 QQCRSRRCPSSPRARLTRPHRSCRDPAVHHALFSGNLQQVQA-LFQDEEAANMIVETVS- :: :... ...: :.: . .. . :. . XP_016 MDGTTAPVTKSGAAKLVKRNFLEALKSNDFGKLKAILIQRQIDVDTVFEVEDE 10 20 30 40 50 100 110 120 130 140 pF1KE4 NQLAWSAEQGFWVLTPKTKQT--APLAIATARGYTDCARHLIRQGAELDARVGGRAALHE :.. : .::.:. . : :.. . : ... :...: :. ..: .. : .:.. :: XP_016 NMVLASYKQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHV 60 70 80 90 100 110 150 160 170 180 190 200 pF1KE4 ACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAG-E :: :. :::..: ::: : . : : ::.:: : :. ::: :. ::.::. .. . XP_016 ACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQ 120 130 140 150 160 170 210 220 230 240 250 260 pF1KE4 SQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGA----EGPGSCRRHQ ..:::::.:: :: . ::.:.:::: : ... :: : : : : : . :. XP_016 DEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTE-HH 180 190 200 210 220 230 270 280 290 300 310 320 pF1KE4 AAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCA . : ::. :.. : ..:::.: : : ...:. ::.:.. . : . .. . XP_016 LVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYV 240 250 260 270 280 290 330 340 350 360 370 380 pF1KE4 LQAVQDSPNWEPEVLFAALLDYGAQPVRP----EMLKHCANFPRALEVLLNAYPCVPSCE :.... : .::. . ::..:: . : .... : . :.:.::..::: . XP_016 LKVTSVRPAAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWNT 300 310 320 330 340 350 390 400 410 420 430 440 pF1KE4 TWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLPLPPLL : .:. XP_016 KWRRAIPDDDLEGIRK 360 >>NP_665879 (OMIM: 605761) ankyrin repeat and SOCS box p (349 aa) initn: 431 init1: 221 opt: 496 Z-score: 396.1 bits: 82.1 E(85289): 2.5e-15 Smith-Waterman score: 496; 31.6% identity (61.6% similar) in 320 aa overlap (64-372:24-343) 40 50 60 70 80 90 pF1KE4 QQCRSRRCPSSPRARLTRPHRSCRDPAVHHALFSGNLQQVQA-LFQDEEAANMIVETVS- :: :... ...: :.: . .. . :. . NP_665 MDGTTAPVTKSGAAKLVKRNFLEALKSNDFGKLKAILIQRQIDVDTVFEVEDE 10 20 30 40 50 100 110 120 130 140 pF1KE4 NQLAWSAEQGFWVLTPKTKQT--APLAIATARGYTDCARHLIRQGAELDARVGGRAALHE :.. : .::.:. . : :.. . : ... :...: :. ..: .. : .:.. :: NP_665 NMVLASYKQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHV 60 70 80 90 100 110 150 160 170 180 190 200 pF1KE4 ACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAG-E :: :. :::..: ::: : . : : ::.:: : :. ::: :. ::.::. .. . NP_665 ACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQ 120 130 140 150 160 170 210 220 230 240 250 260 pF1KE4 SQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGA---EGPGSCRRHQA ..:::::.:: :: . ::.:.:::: : ... :: : : : . .:. NP_665 DEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHL 180 190 200 210 220 230 270 280 290 300 310 320 pF1KE4 AARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCAL . : ::. :.. : ..:::.: : : ...:. ::.:.. . : . .. .: NP_665 VCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVL 240 250 260 270 280 290 330 340 350 360 370 380 pF1KE4 QAVQDSPNWEPEVLFAALLDYGAQPVRPEMLKH---CANFPRALEVLLNAYPCVPSCETW .... : .::. . ::..:: . : .... : : .. . : NP_665 KVTSVRPAAQPEICYQLLLNHGAARIYPPQFHKVRLCPVVSRLRKIQMAALSEISK 300 310 320 330 340 390 400 410 420 430 440 pF1KE4 VEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLPLPPLLRD >>NP_001183959 (OMIM: 610500) ankyrin repeat and KH doma (581 aa) initn: 368 init1: 198 opt: 320 Z-score: 260.5 bits: 57.8 E(85289): 9e-08 Smith-Waterman score: 335; 31.1% identity (59.2% similar) in 267 aa overlap (114-372:275-527) 90 100 110 120 130 140 pF1KE4 NMIVETVSNQLAWSAEQGFWVLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVG- :: :.. :: : .. :. . :..... . NP_001 ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSAT 250 260 270 280 290 300 150 160 170 180 190 200 pF1KE4 GRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATV : .:: ::: . : :..::. ::. . .:.: ::: . .. :..::. :: . NP_001 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 310 320 330 340 350 360 210 220 230 240 250 260 pF1KE4 NLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRR : ..: .:. : .: .: . : . :: ::: .:.. .::: :: .: NP_001 NTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEAC--MDG------ 370 380 390 400 410 270 280 290 300 310 pF1KE4 HQAAARRLLEAGADARAAGRKRHTPLHNACANGCGG---LAELLLRYGARAEVPNGAGHT : .:: ::..::.. . . ..:: : .::: :: ::.. :: : : :.: NP_001 HVEVARLLLDSGAQVNMPADSFESPLTLA---ACGGHVELAALLIERGANLEEVNDEGYT 420 430 440 450 460 470 320 330 340 350 360 370 pF1KE4 PMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRPE----MLKHCANFPRALEVLLNAYPC :. ..:.... . .:.: . .:: . . : :..: .. . :..: NP_001 PL---MEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD 480 490 500 510 520 530 380 390 400 410 420 430 pF1KE4 VPSCETWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLP NP_001 IELGCSTPLMEASQEGHLELVKYLLASGQAGGHEDYFGGHRSGQASGEGGL 540 550 560 570 580 >>NP_060448 (OMIM: 610500) ankyrin repeat and KH domain- (616 aa) initn: 368 init1: 198 opt: 320 Z-score: 260.2 bits: 57.8 E(85289): 9.4e-08 Smith-Waterman score: 335; 31.1% identity (59.2% similar) in 267 aa overlap (114-372:264-516) 90 100 110 120 130 140 pF1KE4 NMIVETVSNQLAWSAEQGFWVLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVG- :: :.. :: : .. :. . :..... . NP_060 ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSAT 240 250 260 270 280 290 150 160 170 180 190 200 pF1KE4 GRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATV : .:: ::: . : :..::. ::. . .:.: ::: . .. :..::. :: . NP_060 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 300 310 320 330 340 350 210 220 230 240 250 260 pF1KE4 NLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRR : ..: .:. : .: .: . : . :: ::: .:.. .::: :: .: NP_060 NTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEAC--MDG------ 360 370 380 390 400 270 280 290 300 310 pF1KE4 HQAAARRLLEAGADARAAGRKRHTPLHNACANGCGG---LAELLLRYGARAEVPNGAGHT : .:: ::..::.. . . ..:: : .::: :: ::.. :: : : :.: NP_060 HVEVARLLLDSGAQVNMPADSFESPLTLA---ACGGHVELAALLIERGANLEEVNDEGYT 410 420 430 440 450 460 320 330 340 350 360 370 pF1KE4 PMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRPE----MLKHCANFPRALEVLLNAYPC :. ..:.... . .:.: . .:: . . : :..: .. . :..: NP_060 PL---MEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD 470 480 490 500 510 380 390 400 410 420 430 pF1KE4 VPSCETWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLP NP_060 IELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQA 520 530 540 550 560 570 >>NP_078944 (OMIM: 610500) ankyrin repeat and KH domain- (627 aa) initn: 368 init1: 198 opt: 320 Z-score: 260.1 bits: 57.8 E(85289): 9.5e-08 Smith-Waterman score: 335; 31.1% identity (59.2% similar) in 267 aa overlap (114-372:275-527) 90 100 110 120 130 140 pF1KE4 NMIVETVSNQLAWSAEQGFWVLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVG- :: :.. :: : .. :. . :..... . NP_078 ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSAT 250 260 270 280 290 300 150 160 170 180 190 200 pF1KE4 GRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATV : .:: ::: . : :..::. ::. . .:.: ::: . .. :..::. :: . NP_078 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 310 320 330 340 350 360 210 220 230 240 250 260 pF1KE4 NLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRR : ..: .:. : .: .: . : . :: ::: .:.. .::: :: .: NP_078 NTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEAC--MDG------ 370 380 390 400 410 270 280 290 300 310 pF1KE4 HQAAARRLLEAGADARAAGRKRHTPLHNACANGCGG---LAELLLRYGARAEVPNGAGHT : .:: ::..::.. . . ..:: : .::: :: ::.. :: : : :.: NP_078 HVEVARLLLDSGAQVNMPADSFESPLTLA---ACGGHVELAALLIERGANLEEVNDEGYT 420 430 440 450 460 470 320 330 340 350 360 370 pF1KE4 PMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRPE----MLKHCANFPRALEVLLNAYPC :. ..:.... . .:.: . .:: . . : :..: .. . :..: NP_078 PL---MEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD 480 490 500 510 520 530 380 390 400 410 420 430 pF1KE4 VPSCETWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLP NP_078 IELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQA 540 550 560 570 580 590 453 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 15:16:10 2016 done: Mon Nov 7 15:16:12 2016 Total Scan time: 8.290 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]